-- dump date 20140620_065557 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_309034.1 74310615 3666269 190..255 1 NC_007384.1 involved in threonine biosynthesis; controls the expression of the thrLABC operon; thr operon leader peptide 255 thrL 3666269 thrL Shigella sonnei Ss046 thr operon leader peptide YP_309034.1 190 D 300269 CDS YP_309035.1 74310616 3666270 337..2799 1 NC_007384.1 homoserine dehydrogenase I; multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 2799 thrA 3666270 thrA Shigella sonnei Ss046 bifunctional aspartokinase I/homoserine dehydrogenase I YP_309035.1 337 D 300269 CDS YP_309036.1 74310617 3666271 2801..3733 1 NC_007384.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 3733 thrB 3666271 thrB Shigella sonnei Ss046 homoserine kinase YP_309036.1 2801 D 300269 CDS YP_309037.1 74310618 3666272 3734..5020 1 NC_007384.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 5020 thrC 3666272 thrC Shigella sonnei Ss046 threonine synthase YP_309037.1 3734 D 300269 CDS YP_309038.1 74310619 3666273 5234..5530 1 NC_007384.1 hypothetical protein 5530 3666273 SSON_0005 Shigella sonnei Ss046 hypothetical protein YP_309038.1 5234 D 300269 CDS YP_309039.1 74310620 3666274 complement(5683..6459) 1 NC_007384.1 Code: S; COG: COG3022; hypothetical protein 6459 yaaA 3666274 yaaA Shigella sonnei Ss046 hypothetical protein YP_309039.1 5683 R 300269 CDS YP_309040.1 74310621 3666275 7446..7949 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 7949 3666275 SSON_0007 Shigella sonnei Ss046 IS1 ORF YP_309040.1 7446 D 300269 CDS YP_309041.1 74310622 3666277 9014..9967 1 NC_007384.1 Code: G; COG: COG0176; transaldolase B 9967 talB 3666277 talB Shigella sonnei Ss046 transaldolase B YP_309041.1 9014 D 300269 CDS YP_309042.1 74310623 3666278 10082..10669 1 NC_007384.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 10669 mogA 3666278 mogA Shigella sonnei Ss046 molybdenum cofactor biosynthesis protein MogA YP_309042.1 10082 D 300269 CDS YP_309043.1 74310624 3666279 complement(10704..11270) 1 NC_007384.1 Code: S; COG: COG1584; hypothetical protein 11270 yaaH 3666279 yaaH Shigella sonnei Ss046 hypothetical protein YP_309043.1 10704 R 300269 CDS YP_309044.1 74310625 3666280 complement(11419..12132) 1 NC_007384.1 Code: S; COG: COG4735; hypothetical protein 12132 3666280 SSON_0012 Shigella sonnei Ss046 hypothetical protein YP_309044.1 11419 R 300269 CDS YP_309045.1 74310626 3666281 complement(12158..12562) 1 NC_007384.1 hypothetical protein 12562 yaaI 3666281 yaaI Shigella sonnei Ss046 hypothetical protein YP_309045.1 12158 R 300269 CDS YP_309046.1 74310627 3666282 12939..14855 1 NC_007384.1 DNA biosynthesis; autoregulated heat shock proteins; heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 14855 dnaK 3666282 dnaK Shigella sonnei Ss046 molecular chaperone DnaK YP_309046.1 12939 D 300269 CDS YP_309047.1 74310628 3666283 14944..16074 1 NC_007384.1 heat shock protein; chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 16074 dnaJ 3666283 dnaJ Shigella sonnei Ss046 molecular chaperone DnaJ YP_309047.1 14944 D 300269 CDS YP_309048.1 74310629 3666284 complement(16178..16387) 1 NC_007384.1 Gef protein 16387 gef 3666284 gef Shigella sonnei Ss046 Gef protein YP_309048.1 16178 R 300269 CDS YP_309049.1 74310630 3666285 complement(17028..17855) 1 NC_007384.1 Code: L; COG: COG3547; transposase 17855 3666285 SSON_0017 Shigella sonnei Ss046 transposase YP_309049.1 17028 R 300269 CDS YP_309050.1 74310631 3666286 17921..19093 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 19093 3666286 SSON_0018 Shigella sonnei Ss046 IS21 ORF1 YP_309050.1 17921 D 300269 CDS YP_309051.1 74310632 3666287 19093..19890 1 NC_007384.1 Code: L; COG: COG1484; IS21 ORF2 19890 3666287 SSON_0019 Shigella sonnei Ss046 IS21 ORF2 YP_309051.1 19093 D 300269 CDS YP_309052.1 74310633 3666288 complement(19900..20289) 1 NC_007384.1 hypothetical protein 20289 3666288 SSON_0020 Shigella sonnei Ss046 hypothetical protein YP_309052.1 19900 R 300269 CDS YP_309053.1 74310634 3666366 20572..21738 1 NC_007384.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 21738 nhaA 3666366 nhaA Shigella sonnei Ss046 pH-dependent sodium/proton antiporter YP_309053.1 20572 D 300269 CDS YP_309054.1 74310635 3666367 21798..22703 1 NC_007384.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 22703 nhaR 3666367 nhaR Shigella sonnei Ss046 transcriptional activator NhaR YP_309054.1 21798 D 300269 CDS YP_309055.1 74310636 3666368 complement(22741..23424) 1 NC_007384.1 hypothetical protein 23424 3666368 SSON_0023 Shigella sonnei Ss046 hypothetical protein YP_309055.1 22741 R 300269 CDS YP_309056.1 74310637 3666369 complement(23714..24517) 1 NC_007384.1 hypothetical protein 24517 3666369 SSON_0024 Shigella sonnei Ss046 hypothetical protein YP_309056.1 23714 R 300269 CDS YP_309057.1 74310638 3666370 24753..25256 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 25256 3666370 SSON_0025 Shigella sonnei Ss046 IS1 ORF YP_309057.1 24753 D 300269 CDS YP_309058.1 74310639 3666371 complement(25267..25635) 1 NC_007384.1 hypothetical protein 25635 3666371 SSON_0026 Shigella sonnei Ss046 hypothetical protein YP_309058.1 25267 R 300269 CDS YP_309059.1 74310640 3666372 complement(26076..27197) 1 NC_007384.1 hypothetical protein 27197 3666372 SSON_0027 Shigella sonnei Ss046 hypothetical protein YP_309059.1 26076 R 300269 CDS YP_309060.1 74310641 3666373 complement(27981..28244) 1 NC_007384.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 28244 rpsT 3666373 rpsT Shigella sonnei Ss046 30S ribosomal protein S20 YP_309060.1 27981 R 300269 CDS YP_309061.1 74310642 3666374 28347..28565 1 NC_007384.1 hypothetical protein 28565 3666374 SSON_0029 Shigella sonnei Ss046 hypothetical protein YP_309061.1 28347 D 300269 CDS YP_309062.1 74310643 3666375 28573..29514 1 NC_007384.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 29514 ribF 3666375 ribF Shigella sonnei Ss046 bifunctional riboflavin kinase/FMN adenylyltransferase YP_309062.1 28573 D 300269 CDS YP_309063.1 74310644 3666376 29557..32373 1 NC_007384.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 32373 ileS 3666376 ileS Shigella sonnei Ss046 isoleucyl-tRNA synthetase YP_309063.1 29557 D 300269 CDS YP_309064.1 74310645 3666377 32373..32867 1 NC_007384.1 SPase II; lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 32867 lspA 3666377 lspA Shigella sonnei Ss046 lipoprotein signal peptidase YP_309064.1 32373 D 300269 CDS YP_309065.1 74310646 3666378 32992..33441 1 NC_007384.1 a rotamase; Code: O; COG: COG1047; peptidyl-prolyl cis- trans isomerase 33441 slpA 3666378 slpA Shigella sonnei Ss046 peptidyl-prolyl cis- trans isomerase YP_309065.1 32992 D 300269 CDS YP_309066.1 74310647 3666379 33443..34393 1 NC_007384.1 involved in penicillin tolerance; catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 34393 ispH 3666379 ispH Shigella sonnei Ss046 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_309066.1 33443 D 300269 CDS YP_309067.1 74310648 3666380 34459..35373 1 NC_007384.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 35373 yaaF 3666380 yaaF Shigella sonnei Ss046 ribonucleoside hydrolase RihC YP_309067.1 34459 D 300269 CDS YP_309068.1 74310649 3666381 35540..36361 1 NC_007384.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 36361 dapB 3666381 dapB Shigella sonnei Ss046 dihydrodipicolinate reductase YP_309068.1 35540 D 300269 CDS YP_309069.1 74310650 3666382 36817..37965 1 NC_007384.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 37965 carA 3666382 carA Shigella sonnei Ss046 carbamoyl phosphate synthase small subunit YP_309069.1 36817 D 300269 CDS YP_309070.1 74310651 3666383 37983..41204 1 NC_007384.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 41204 carB 3666383 carB Shigella sonnei Ss046 carbamoyl phosphate synthase large subunit YP_309070.1 37983 D 300269 CDS YP_309071.1 74310652 3666384 complement(41371..41874) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 41874 3666384 SSON_0039 Shigella sonnei Ss046 IS1 ORF YP_309071.1 41371 R 300269 CDS YP_309072.2 161986601 3670636 42242..42637 1 NC_007384.1 regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; DNA-binding transcriptional activator CaiF 42637 caiF 3670636 caiF Shigella sonnei Ss046 DNA-binding transcriptional activator CaiF YP_309072.2 42242 D 300269 CDS YP_309073.1 74310654 3670637 complement(42846..43457) 1 NC_007384.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE 43457 caiE 3670637 caiE Shigella sonnei Ss046 carnitine operon protein CaiE YP_309073.1 42846 R 300269 CDS YP_309074.1 74310655 3670638 complement(43442..44335) 1 NC_007384.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase 44335 caiD 3670638 caiD Shigella sonnei Ss046 carnitinyl-CoA dehydratase YP_309074.1 43442 R 300269 CDS YP_309075.1 74310656 3670639 complement(44336..45904) 1 NC_007384.1 Code: IQ; COG: COG0318; crotonobetaine/carnitine-CoA ligase 45904 caiC 3670639 caiC Shigella sonnei Ss046 crotonobetaine/carnitine-CoA ligase YP_309075.1 44336 R 300269 CDS YP_309076.1 74310657 3670640 46053..46355 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 46355 3670640 SSON_0044 Shigella sonnei Ss046 IS600 ORF1 YP_309076.1 46053 D 300269 CDS YP_309077.1 74310658 3670641 46496..47209 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 47209 3670641 SSON_0045 Shigella sonnei Ss046 IS600 ORF2 YP_309077.1 46496 D 300269 CDS YP_309078.1 74310659 3670643 complement(48576..49718) 1 NC_007384.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase 49718 caiA 3670643 caiA Shigella sonnei Ss046 crotonobetainyl-CoA dehydrogenase YP_309078.1 48576 R 300269 CDS YP_309079.1 74310660 3670644 complement(49749..51263) 1 NC_007384.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter 51263 caiT 3670644 caiT Shigella sonnei Ss046 L-carnitine/gamma-butyrobetaine antiporter YP_309079.1 49749 R 300269 CDS YP_309080.2 161986600 3670645 51737..52507 1 NC_007384.1 probable flavoprotein subunit, carnitine metabolism; required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; electron transfer flavoprotein FixA 52507 fixA 3670645 fixA Shigella sonnei Ss046 electron transfer flavoprotein FixA YP_309080.2 51737 D 300269 CDS YP_309081.1 74310662 3670646 52522..53463 1 NC_007384.1 probable flavoprotein subunit, carnitine metabolism; involved in electron transfer during carnitine metabolism; electron transfer flavoprotein FixB 53463 fixB 3670646 fixB Shigella sonnei Ss046 electron transfer flavoprotein FixB YP_309081.1 52522 D 300269 CDS YP_309082.1 74310663 3670647 53514..54800 1 NC_007384.1 electron transport; FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; oxidoreductase FixC 54800 fixC 3670647 fixC Shigella sonnei Ss046 oxidoreductase FixC YP_309082.1 53514 D 300269 CDS YP_309083.1 74310664 3670648 54797..55084 1 NC_007384.1 Code: C; COG: COG2440; ferredoxin 55084 fixX 3670648 fixX Shigella sonnei Ss046 ferredoxin YP_309083.1 54797 D 300269 CDS YP_309084.1 74310665 3670650 56582..57112 1 NC_007384.1 Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 57112 yabF 3670650 yabF Shigella sonnei Ss046 glutathione-regulated potassium-efflux system ancillary protein KefF YP_309084.1 56582 D 300269 CDS YP_309085.1 74310666 3670651 57105..58967 1 NC_007384.1 glutathione-regulated; transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 58967 kefC 3670651 kefC Shigella sonnei Ss046 glutathione-regulated potassium-efflux system protein KefC YP_309085.1 57105 D 300269 CDS YP_309086.1 74310667 3670652 59159..59638 1 NC_007384.1 trimethoprim resistance; catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 59638 folA 3670652 folA Shigella sonnei Ss046 dihydrofolate reductase YP_309086.1 59159 D 300269 CDS YP_309087.1 74310668 3670653 complement(59716..60558) 1 NC_007384.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 60558 apaH 3670653 apaH Shigella sonnei Ss046 diadenosine tetraphosphatase YP_309087.1 59716 R 300269 CDS YP_309088.1 74310669 3670654 complement(60565..60942) 1 NC_007384.1 protein associated with Co2+ and Mg2+ efflux; ApaG protein 60942 apaG 3670654 apaG Shigella sonnei Ss046 ApaG protein YP_309088.1 60565 R 300269 CDS YP_309089.1 74310670 3670655 complement(60945..61766) 1 NC_007384.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 61766 ksgA 3670655 ksgA Shigella sonnei Ss046 dimethyladenosine transferase YP_309089.1 60945 R 300269 CDS YP_309090.1 74310671 3668734 complement(61763..62752) 1 NC_007384.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase 62752 pdxA 3668734 pdxA Shigella sonnei Ss046 4-hydroxythreonine-4-phosphate dehydrogenase YP_309090.1 61763 R 300269 CDS YP_309091.1 74310672 3668735 complement(62752..64038) 1 NC_007384.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA 64038 surA 3668735 surA Shigella sonnei Ss046 peptidyl-prolyl cis-trans isomerase SurA YP_309091.1 62752 R 300269 CDS YP_309092.1 74310673 3668736 complement(64091..66445) 1 NC_007384.1 determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein 66445 imp 3668736 imp Shigella sonnei Ss046 organic solvent tolerance protein YP_309092.1 64091 R 300269 CDS YP_309093.1 74310674 3668737 66700..67515 1 NC_007384.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 67515 djlA 3668737 djlA Shigella sonnei Ss046 Dna-J like membrane chaperone protein YP_309093.1 66700 D 300269 CDS YP_309094.1 74310675 3668738 complement(67632..68291) 1 NC_007384.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A 68291 yabO 3668738 yabO Shigella sonnei Ss046 23S rRNA/tRNA pseudouridine synthase A YP_309094.1 67632 R 300269 CDS YP_309095.1 74310676 3668739 complement(68303..71209) 1 NC_007384.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA 71209 hepA 3668739 hepA Shigella sonnei Ss046 ATP-dependent helicase HepA YP_309095.1 68303 R 300269 CDS YP_309096.1 74310677 3668740 complement(71373..73724) 1 NC_007384.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II 73724 polB 3668740 polB Shigella sonnei Ss046 DNA polymerase II YP_309096.1 71373 R 300269 CDS YP_309097.1 74310678 3668741 complement(73799..74494) 1 NC_007384.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 74494 araD 3668741 araD Shigella sonnei Ss046 L-ribulose-5-phosphate 4-epimerase YP_309097.1 73799 R 300269 CDS YP_309098.1 74310679 3668742 complement(74663..76165) 1 NC_007384.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase 76165 araA 3668742 araA Shigella sonnei Ss046 L-arabinose isomerase YP_309098.1 74663 R 300269 CDS YP_309099.1 74310680 3668743 complement(76176..77876) 1 NC_007384.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase 77876 araB 3668743 araB Shigella sonnei Ss046 ribulokinase YP_309099.1 76176 R 300269 CDS YP_309100.1 74310681 3668744 78215..79093 1 NC_007384.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; DNA-binding transcriptional regulator AraC 79093 araC 3668744 araC Shigella sonnei Ss046 DNA-binding transcriptional regulator AraC YP_309100.1 78215 D 300269 CDS YP_309101.1 74310682 3668745 79179..79943 1 NC_007384.1 Code: S; COG: COG0586; hypothetical protein 79943 yabI 3668745 yabI Shigella sonnei Ss046 hypothetical protein YP_309101.1 79179 D 300269 CDS YP_309102.1 74310683 3668746 complement(80013..80711) 1 NC_007384.1 with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding subunit 80711 thiQ 3668746 thiQ Shigella sonnei Ss046 thiamine transporter ATP-binding subunit YP_309102.1 80013 R 300269 CDS YP_309103.1 74310684 3668747 complement(80695..82305) 1 NC_007384.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein 82305 thiP 3668747 thiP Shigella sonnei Ss046 thiamine transporter membrane protein YP_309103.1 80695 R 300269 CDS YP_309104.1 74310685 3668748 complement(82281..83264) 1 NC_007384.1 part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit 83264 tbpA 3668748 tbpA Shigella sonnei Ss046 thiamine transporter substrate binding subunit YP_309104.1 82281 R 300269 CDS YP_309105.1 74310686 3668749 complement(83428..85083) 1 NC_007384.1 activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR 85083 yabN 3668749 yabN Shigella sonnei Ss046 transcriptional regulator SgrR YP_309105.1 83428 R 300269 CDS YP_309106.1 74310687 3668750 85405..86520 1 NC_007384.1 Code: GEPR; COG: COG0477; transporter 86520 yabM 3668750 yabM Shigella sonnei Ss046 transporter YP_309106.1 85405 D 300269 CDS YP_309107.1 74310688 3668751 86769..87272 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 87272 3668751 SSON_0077 Shigella sonnei Ss046 IS1 ORF YP_309107.1 86769 D 300269 CDS YP_309108.1 74310689 3668752 complement(87408..88013) 1 NC_007384.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 88013 leuD 3668752 leuD Shigella sonnei Ss046 isopropylmalate isomerase small subunit YP_309108.1 87408 R 300269 CDS YP_309109.1 74310690 3668451 complement(88024..89424) 1 NC_007384.1 dehydratase; dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 89424 leuC 3668451 leuC Shigella sonnei Ss046 isopropylmalate isomerase large subunit YP_309109.1 88024 R 300269 CDS YP_309110.2 161986599 3668452 complement(89427..90518) 1 NC_007384.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 90518 leuB 3668452 leuB Shigella sonnei Ss046 3-isopropylmalate dehydrogenase YP_309110.2 89427 R 300269 CDS YP_309111.1 74310692 3668453 complement(90518..92089) 1 NC_007384.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 92089 leuA 3668453 leuA Shigella sonnei Ss046 2-isopropylmalate synthase YP_309111.1 90518 R 300269 CDS YP_309112.1 74310693 3668454 complement(92182..92268) 1 NC_007384.1 involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide 92268 leuL 3668454 leuL Shigella sonnei Ss046 leu operon leader peptide YP_309112.1 92182 R 300269 CDS YP_309113.2 161986598 3668455 92928..93872 1 NC_007384.1 activator for leuABCD operon; member of LysR family of transcriptional activators; leucine transcriptional activator 93872 leuO 3668455 leuO Shigella sonnei Ss046 leucine transcriptional activator YP_309113.2 92928 D 300269 CDS YP_309114.1 74310695 3668456 94190..95914 1 NC_007384.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 95914 ilvI 3668456 ilvI Shigella sonnei Ss046 acetolactate synthase 3 catalytic subunit YP_309114.1 94190 D 300269 CDS YP_309115.1 74310696 3668457 95917..96408 1 NC_007384.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 96408 ilvH 3668457 ilvH Shigella sonnei Ss046 acetolactate synthase 3 regulatory subunit YP_309115.1 95917 D 300269 CDS YP_309117.1 74310698 3668459 96588..97592 1 NC_007384.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 97592 fruR 3668459 fruR Shigella sonnei Ss046 DNA-binding transcriptional regulator FruR YP_309117.1 96588 D 300269 CDS YP_309118.1 74310699 3668460 97888..98391 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 98391 3668460 SSON_0088 Shigella sonnei Ss046 IS1 ORF YP_309118.1 97888 D 300269 CDS YP_309119.1 74310700 3668461 98971..99429 1 NC_007384.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 99429 yabB 3668461 yabB Shigella sonnei Ss046 cell division protein MraZ YP_309119.1 98971 D 300269 CDS YP_309120.1 74310701 3668462 99431..100372 1 NC_007384.1 Code: M; COG: COG0275; S-adenosyl-methyltransferase MraW 100372 mraW 3668462 mraW Shigella sonnei Ss046 S-adenosyl-methyltransferase MraW YP_309120.1 99431 D 300269 CDS YP_309121.1 74310702 3668463 100369..100734 1 NC_007384.1 ingrowth of wall at septum; membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 100734 ftsL 3668463 ftsL Shigella sonnei Ss046 cell division protein FtsL YP_309121.1 100369 D 300269 CDS YP_309122.1 74310703 3668464 100750..102516 1 NC_007384.1 Code: M; COG: COG0768; septum formation peptidoglycan synthetase 102516 ftsI 3668464 ftsI Shigella sonnei Ss046 septum formation peptidoglycan synthetase YP_309122.1 100750 D 300269 CDS YP_309123.1 74310704 3668465 102503..103996 1 NC_007384.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 103996 murE 3668465 murE Shigella sonnei Ss046 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_309123.1 102503 D 300269 CDS YP_309124.1 74310705 3668466 103993..105351 1 NC_007384.1 Code: M; COG: COG0770; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 105351 murF 3668466 murF Shigella sonnei Ss046 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase YP_309124.1 103993 D 300269 CDS YP_309125.1 74310706 3668467 105345..106427 1 NC_007384.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 106427 mraY 3668467 mraY Shigella sonnei Ss046 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_309125.1 105345 D 300269 CDS YP_309126.1 74310707 3668468 106430..107746 1 NC_007384.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 107746 murD 3668468 murD Shigella sonnei Ss046 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_309126.1 106430 D 300269 CDS YP_309127.1 74310708 3668469 107746..108990 1 NC_007384.1 membrane protein involved in shape determination; integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 108990 ftsW 3668469 ftsW Shigella sonnei Ss046 cell division protein FtsW YP_309127.1 107746 D 300269 CDS YP_309128.1 74310709 3668470 108987..110054 1 NC_007384.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 110054 murG 3668470 murG Shigella sonnei Ss046 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase YP_309128.1 108987 D 300269 CDS YP_309129.1 74310710 3670656 110108..111583 1 NC_007384.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 111583 murC 3670656 murC Shigella sonnei Ss046 UDP-N-acetylmuramate--L-alanine ligase YP_309129.1 110108 D 300269 CDS YP_309130.1 74310711 3670657 111576..112496 1 NC_007384.1 affects cell division; D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 112496 ddl 3670657 ddl Shigella sonnei Ss046 D-alanine--D-alanine ligase YP_309130.1 111576 D 300269 CDS YP_309131.1 74310712 3670658 112498..113328 1 NC_007384.1 ingrowth of wall at septum; involved in septum formation; cell division protein FtsQ 113328 ftsQ 3670658 ftsQ Shigella sonnei Ss046 cell division protein FtsQ YP_309131.1 112498 D 300269 CDS YP_309132.1 74310713 3670659 113325..114587 1 NC_007384.1 septation process; complexes with FtsZ; associated with junctions of inner and outer membranes; ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 114587 ftsA 3670659 ftsA Shigella sonnei Ss046 cell division protein FtsA YP_309132.1 113325 D 300269 CDS YP_309133.1 74310714 3670660 114648..115799 1 NC_007384.1 cell division; forms circumferential ring; tubulin-like GTP-binding protein and GTPase; GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 115799 ftsZ 3670660 ftsZ Shigella sonnei Ss046 cell division protein FtsZ YP_309133.1 114648 D 300269 CDS YP_309134.1 74310715 3670661 115900..116817 1 NC_007384.1 lipid A biosynthesis; zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 116817 lpxC 3670661 lpxC Shigella sonnei Ss046 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_309134.1 115900 D 300269 CDS YP_309135.2 161986597 3670662 117048..117560 1 NC_007384.1 secM translational pause allows for the initiation of secA translation; SecA regulator SecM 117560 yacA 3670662 yacA Shigella sonnei Ss046 SecA regulator SecM YP_309135.2 117048 D 300269 CDS YP_309136.1 74310717 3670663 117622..120327 1 NC_007384.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 120327 secA 3670663 secA Shigella sonnei Ss046 preprotein translocase subunit SecA YP_309136.1 117622 D 300269 CDS YP_309137.1 74310718 3670664 120387..120776 1 NC_007384.1 prefers dGTP; causes AT-GC transversions; Code: LR; COG: COG0494; nucleoside triphosphate pyrophosphohydrolase 120776 mutT 3670664 mutT Shigella sonnei Ss046 nucleoside triphosphate pyrophosphohydrolase YP_309137.1 120387 D 300269 CDS YP_309138.1 74310719 3670665 complement(120791..120925) 1 NC_007384.1 hypothetical protein 120925 3670665 SSON_0108 Shigella sonnei Ss046 hypothetical protein YP_309138.1 120791 R 300269 CDS YP_309139.1 74310720 3670666 complement(120876..121073) 1 NC_007384.1 Code: S; COG: COG3024; zinc-binding protein 121073 yacG 3670666 yacG Shigella sonnei Ss046 zinc-binding protein YP_309139.1 120876 R 300269 CDS YP_309140.1 74310721 3670667 complement(121083..121826) 1 NC_007384.1 Code: S; COG: COG4582; hypothetical protein 121826 yacF 3670667 yacF Shigella sonnei Ss046 hypothetical protein YP_309140.1 121083 R 300269 CDS YP_309141.1 74310722 3670668 complement(121826..122446) 1 NC_007384.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 122446 coaE 3670668 coaE Shigella sonnei Ss046 dephospho-CoA kinase YP_309141.1 121826 R 300269 CDS YP_309142.1 74310723 3670669 122671..123714 1 NC_007384.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 123714 guaC 3670669 guaC Shigella sonnei Ss046 guanosine 5'-monophosphate oxidoreductase YP_309142.1 122671 D 300269 CDS YP_309143.1 74310724 3670670 complement(123634..123741) 1 NC_007384.1 hypothetical protein 123741 3670670 SSON_0113 Shigella sonnei Ss046 hypothetical protein YP_309143.1 123634 R 300269 CDS YP_309144.1 74310725 3670671 complement(123749..124951) 1 NC_007384.1 involved in biogenesis of fimbriae, protein transport, DNA uptake; Code: NU; COG: COG1459; type IV pilin biogenesis protein 124951 hofC 3670671 hofC Shigella sonnei Ss046 type IV pilin biogenesis protein YP_309144.1 123749 R 300269 CDS YP_309145.1 74310726 3670673 complement(126337..126777) 1 NC_007384.1 Code: NU; COG: COG4969; major pilin subunit 126777 ppdD 3670673 ppdD Shigella sonnei Ss046 major pilin subunit YP_309145.1 126337 R 300269 CDS YP_309146.1 74310727 3670674 complement(126980..127873) 1 NC_007384.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase 127873 nadC 3670674 nadC Shigella sonnei Ss046 quinolinate phosphoribosyltransferase YP_309146.1 126980 R 300269 CDS YP_309147.1 74310728 3669399 127961..128512 1 NC_007384.1 Code: V; COG: COG3023; N-acetyl-anhydromuranmyl-L-alanine amidase 128512 ampD 3669399 ampD Shigella sonnei Ss046 N-acetyl-anhydromuranmyl-L-alanine amidase YP_309147.1 127961 D 300269 CDS YP_309148.1 74310729 3669400 128509..129363 1 NC_007384.1 involved in regulation of beta-lactamase; signaling protein; regulatory protein AmpE 129363 ampE 3669400 ampE Shigella sonnei Ss046 regulatory protein AmpE YP_309148.1 128509 D 300269 CDS YP_309149.1 74310730 3669401 complement(129406..130779) 1 NC_007384.1 Code: E; COG: COG1113; aromatic amino acid transporter 130779 aroP 3669401 aroP Shigella sonnei Ss046 aromatic amino acid transporter YP_309149.1 129406 R 300269 CDS YP_309150.1 74310731 3669402 131320..132084 1 NC_007384.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 132084 pdhR 3669402 pdhR Shigella sonnei Ss046 transcriptional regulator PdhR YP_309150.1 131320 D 300269 CDS YP_309151.1 74310732 3669403 132245..134908 1 NC_007384.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 134908 aceE 3669403 aceE Shigella sonnei Ss046 pyruvate dehydrogenase subunit E1 YP_309151.1 132245 D 300269 CDS YP_309152.1 74310733 3669404 134923..136815 1 NC_007384.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 136815 aceF 3669404 aceF Shigella sonnei Ss046 dihydrolipoamide acetyltransferase YP_309152.1 134923 D 300269 CDS YP_309153.1 74310734 3669405 137140..138564 1 NC_007384.1 component of 2-oxodehydrogenase and pyruvate complexes; L-protein of glycine cleavage complex; E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 138564 lpdA 3669405 lpdA Shigella sonnei Ss046 dihydrolipoamide dehydrogenase YP_309153.1 137140 D 300269 CDS YP_309154.1 74310735 3669406 complement(138635..140392) 1 NC_007384.1 hypothetical protein 140392 yacH 3669406 yacH Shigella sonnei Ss046 hypothetical protein YP_309154.1 138635 R 300269 CDS YP_309155.1 74310736 3669407 140747..143344 1 NC_007384.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 143344 acnB 3669407 acnB Shigella sonnei Ss046 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase YP_309155.1 140747 D 300269 CDS YP_309156.1 74310737 3669408 143519..143881 1 NC_007384.1 Code: S; COG: COG3112; hypothetical protein 143881 yacL 3669408 yacL Shigella sonnei Ss046 hypothetical protein YP_309156.1 143519 D 300269 CDS YP_309157.1 74310738 3669409 complement(143919..144713) 1 NC_007384.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase 144713 speD 3669409 speD Shigella sonnei Ss046 S-adenosylmethionine decarboxylase YP_309157.1 143919 R 300269 CDS YP_309158.1 74310739 3669410 complement(144729..145595) 1 NC_007384.1 putrescine aminopropyltransferase; catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 145595 speE 3669410 speE Shigella sonnei Ss046 spermidine synthase YP_309158.1 144729 R 300269 CDS YP_309159.1 74310740 3669411 complement(145701..146171) 1 NC_007384.1 hypothetical protein 146171 yacC 3669411 yacC Shigella sonnei Ss046 hypothetical protein YP_309159.1 145701 R 300269 CDS YP_309160.1 74310741 3669412 146214..147764 1 NC_007384.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 147764 yacK 3669412 yacK Shigella sonnei Ss046 multicopper oxidase YP_309160.1 146214 D 300269 CDS YP_309161.1 74310742 3669413 complement(147811..150201) 1 NC_007384.1 Code: G; COG: COG4993; glucose dehydrogenase 150201 gcd 3669413 gcd Shigella sonnei Ss046 glucose dehydrogenase YP_309161.1 147811 R 300269 CDS YP_309162.2 161986596 3669414 150407..150943 1 NC_007384.1 Code: F; COG: COG0634; hypoxanthine phosphoribosyltransferase 150943 hpt 3669414 hpt Shigella sonnei Ss046 hypoxanthine phosphoribosyltransferase YP_309162.2 150407 D 300269 CDS YP_309163.1 74310744 3669415 complement(150984..151646) 1 NC_007384.1 catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase 151646 yadF 3669415 yadF Shigella sonnei Ss046 carbonic anhydrase YP_309163.1 150984 R 300269 CDS YP_309164.1 74310745 3669416 151755..152681 1 NC_007384.1 Code: V; COG: COG1131; ABC transporter ATP-binding protein 152681 yadG 3669416 yadG Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_309164.1 151755 D 300269 CDS YP_309165.1 74310746 3669417 152678..153448 1 NC_007384.1 Code: V; COG: COG0842; hypothetical protein 153448 yadH 3669417 yadH Shigella sonnei Ss046 hypothetical protein YP_309165.1 152678 D 300269 CDS YP_309166.1 74310747 3669418 153553..153993 1 NC_007384.1 Code: G; COG: COG2893; PTS system transporter subunit IIB 153993 yadI 3669418 yadI Shigella sonnei Ss046 PTS system transporter subunit IIB YP_309166.1 153553 D 300269 CDS YP_309167.1 74310748 3666289 154057..155286 1 NC_007384.1 Code: G; COG: COG0726; hypothetical protein 155286 yadE 3666289 yadE Shigella sonnei Ss046 hypothetical protein YP_309167.1 154057 D 300269 CDS YP_309168.1 74310749 3666290 complement(155290..155670) 1 NC_007384.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 155670 panD 3666290 panD Shigella sonnei Ss046 aspartate alpha-decarboxylase YP_309168.1 155290 R 300269 CDS YP_309169.1 74310750 3666291 155887..156840 1 NC_007384.1 Code: S; COG: COG5464; hypothetical protein 156840 yadD 3666291 yadD Shigella sonnei Ss046 hypothetical protein YP_309169.1 155887 D 300269 CDS YP_309170.1 74310751 3666292 complement(157132..157983) 1 NC_007384.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 157983 panC 3666292 panC Shigella sonnei Ss046 pantoate--beta-alanine ligase YP_309170.1 157132 R 300269 CDS YP_309171.1 74310752 3666293 complement(157995..158789) 1 NC_007384.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 158789 panB 3666293 panB Shigella sonnei Ss046 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_309171.1 157995 R 300269 CDS YP_309172.1 74310753 3666294 159623..160126 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 160126 3666294 SSON_0143 Shigella sonnei Ss046 IS1 ORF YP_309172.1 159623 D 300269 CDS YP_309173.2 161986595 3666295 160653..161558 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 161558 3666295 SSON_0144 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_309173.2 160653 D 300269 CDS YP_309174.1 74310755 3666296 complement(162339..162935) 1 NC_007384.1 fimbrial protein 162935 yadK 3666296 yadK Shigella sonnei Ss046 fimbrial protein YP_309174.1 162339 R 300269 CDS YP_309175.1 74310756 3666297 complement(162962..163564) 1 NC_007384.1 fimbrial protein 163564 yadL 3666297 yadL Shigella sonnei Ss046 fimbrial protein YP_309175.1 162962 R 300269 CDS YP_309176.2 161986594 3666298 complement(164059..164964) 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 164964 3666298 SSON_0147 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_309176.2 164059 R 300269 CDS YP_309177.2 161986593 3666299 complement(164922..165287) 1 NC_007384.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 165287 3666299 SSON_0148 Shigella sonnei Ss046 insertion sequence 2 OrfA protein YP_309177.2 164922 R 300269 CDS YP_309178.1 74310759 3666300 complement(165337..166368) 1 NC_007384.1 Code: L; COG: COG3335; IS630 orf 166368 3666300 SSON_0149 Shigella sonnei Ss046 IS630 orf YP_309178.1 165337 R 300269 CDS YP_309179.1 74310760 3666301 complement(167677..168180) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 168180 3666301 SSON_0150 Shigella sonnei Ss046 IS1 ORF YP_309179.1 167677 R 300269 CDS YP_309180.1 74310761 3666303 complement(169651..170391) 1 NC_007384.1 Code: NU; COG: COG3121; chaperone protein EcpD 170391 ecpD 3666303 ecpD Shigella sonnei Ss046 chaperone protein EcpD YP_309180.1 169651 R 300269 CDS YP_309181.1 74310762 3666304 complement(170496..171080) 1 NC_007384.1 Code: NU; COG: COG3539; fimbrial-like protein 171080 yadN 3666304 yadN Shigella sonnei Ss046 fimbrial-like protein YP_309181.1 170496 R 300269 CDS YP_309182.1 74310763 3666305 complement(171450..171929) 1 NC_007384.1 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 171929 folK 3666305 folK Shigella sonnei Ss046 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_309182.1 171450 R 300269 CDS YP_309183.2 161986592 3666306 complement(171926..173344) 1 NC_007384.1 Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase 173344 pcnB 3666306 pcnB Shigella sonnei Ss046 poly(A) polymerase YP_309183.2 171926 R 300269 CDS YP_309184.2 161986591 3666307 complement(173383..174279) 1 NC_007384.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase 174279 yadB 3666307 yadB Shigella sonnei Ss046 glutamyl-Q tRNA(Asp) synthetase YP_309184.2 173383 R 300269 CDS YP_309185.1 74310766 3668675 complement(174346..174801) 1 NC_007384.1 Code: T; COG: COG1734; RNA polymerase-binding transcription factor 174801 dksA 3668675 dksA Shigella sonnei Ss046 RNA polymerase-binding transcription factor YP_309185.1 174346 R 300269 CDS YP_309186.1 74310767 3668676 complement(174979..175683) 1 NC_007384.1 Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A 175683 sfsA 3668676 sfsA Shigella sonnei Ss046 sugar fermentation stimulation protein A YP_309186.1 174979 R 300269 CDS YP_309187.1 74310768 3668677 complement(175698..176237) 1 NC_007384.1 Code: J; COG: COG1514; hypothetical protein 176237 yadP 3668677 yadP Shigella sonnei Ss046 hypothetical protein YP_309187.1 175698 R 300269 CDS YP_309188.1 74310769 3668678 176257..178731 1 NC_007384.1 similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 178731 hrpB 3668678 hrpB Shigella sonnei Ss046 ATP-dependent RNA helicase HrpB YP_309188.1 176257 D 300269 CDS YP_309189.1 74310770 3668679 178927..181461 1 NC_007384.1 penicillin-binding protein 1B; bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 181461 mrcB 3668679 mrcB Shigella sonnei Ss046 penicillin-binding protein 1b YP_309189.1 178927 D 300269 CDS YP_309190.1 74310771 3668680 181681..183870 1 NC_007384.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 183870 fhuA 3668680 fhuA Shigella sonnei Ss046 ferrichrome outer membrane transporter YP_309190.1 181681 D 300269 CDS YP_309191.1 74310772 3668681 183921..184718 1 NC_007384.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding subunit 184718 fhuC 3668681 fhuC Shigella sonnei Ss046 iron-hydroxamate transporter ATP-binding subunit YP_309191.1 183921 D 300269 CDS YP_309192.1 74310773 3668682 184718..185608 1 NC_007384.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 185608 fhuD 3668682 fhuD Shigella sonnei Ss046 iron-hydroxamate transporter substrate-binding subunit YP_309192.1 184718 D 300269 CDS YP_309193.1 74310774 3668683 185605..187587 1 NC_007384.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 187587 fhuB 3668683 fhuB Shigella sonnei Ss046 iron-hydroxamate transporter permease subunit YP_309193.1 185605 D 300269 CDS YP_309194.1 74310775 3668684 complement(187745..189025) 1 NC_007384.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 189025 hemL 3668684 hemL Shigella sonnei Ss046 glutamate-1-semialdehyde aminotransferase YP_309194.1 187745 R 300269 CDS YP_309195.1 74310776 3668685 189250..190671 1 NC_007384.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 190671 yadQ 3668685 yadQ Shigella sonnei Ss046 chloride channel protein YP_309195.1 189250 D 300269 CDS YP_309196.1 74310777 3668686 190753..191097 1 NC_007384.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 191097 yadR 3668686 yadR Shigella sonnei Ss046 iron-sulfur cluster insertion protein ErpA YP_309196.1 190753 D 300269 CDS YP_309197.1 74310778 3668687 complement(191144..191767) 1 NC_007384.1 Code: S; COG: COG2860; hypothetical protein 191767 yadS 3668687 yadS Shigella sonnei Ss046 hypothetical protein YP_309197.1 191144 R 300269 CDS YP_309198.1 74310779 3668688 complement(191805..192605) 1 NC_007384.1 solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF 192605 yadT 3668688 yadT Shigella sonnei Ss046 vitamin B12-transporter protein BtuF YP_309198.1 191805 R 300269 CDS YP_309199.1 74310780 3668689 complement(192598..193296) 1 NC_007384.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 193296 pfs 3668689 pfs Shigella sonnei Ss046 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_309199.1 192598 R 300269 CDS YP_309200.1 74310781 3668691 194463..194966 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 194966 3668691 SSON_0173 Shigella sonnei Ss046 IS1 ORF YP_309200.1 194463 D 300269 CDS YP_309201.1 74310782 3668692 195804..197228 1 NC_007384.1 heat shock protein HtrA; protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 197228 htrA 3668692 htrA Shigella sonnei Ss046 serine endoprotease YP_309201.1 195804 D 300269 CDS YP_309202.2 161986590 3668693 197383..198540 1 NC_007384.1 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization; carbohydrate diacid transcriptional activator CdaR 198540 yaeG 3668693 yaeG Shigella sonnei Ss046 carbohydrate diacid transcriptional activator CdaR YP_309202.2 197383 D 300269 CDS YP_309203.1 74310784 3668694 complement(198629..199015) 1 NC_007384.1 hypothetical protein 199015 yaeH 3668694 yaeH Shigella sonnei Ss046 hypothetical protein YP_309203.1 198629 R 300269 CDS YP_309204.2 161986589 3668334 complement(199177..199968) 1 NC_007384.1 Code: R; COG: COG1408; phosphodiesterase YaeI 199968 yaeI 3668334 yaeI Shigella sonnei Ss046 phosphodiesterase YaeI YP_309204.2 199177 R 300269 CDS YP_309205.1 74310786 3668335 complement(200044..200868) 1 NC_007384.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 200868 dapD 3668335 dapD Shigella sonnei Ss046 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase YP_309205.1 200044 R 300269 CDS YP_309206.1 74310787 3668336 complement(200899..203571) 1 NC_007384.1 uridylyltransferase acts on regulator of glnA; catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase 203571 glnD 3668336 glnD Shigella sonnei Ss046 PII uridylyl-transferase YP_309206.1 200899 R 300269 CDS YP_309207.1 74310788 3668337 complement(203633..204427) 1 NC_007384.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 204427 map 3668337 map Shigella sonnei Ss046 methionine aminopeptidase YP_309207.1 203633 R 300269 CDS YP_309208.1 74310789 3668338 204795..205520 1 NC_007384.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 205520 rpsB 3668338 rpsB Shigella sonnei Ss046 30S ribosomal protein S2 YP_309208.1 204795 D 300269 CDS YP_309209.1 74310790 3668339 205778..206629 1 NC_007384.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 206629 tsf 3668339 tsf Shigella sonnei Ss046 elongation factor Ts YP_309209.1 205778 D 300269 CDS YP_309210.1 74310791 3668340 206776..207501 1 NC_007384.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 207501 pyrH 3668340 pyrH Shigella sonnei Ss046 uridylate kinase YP_309210.1 206776 D 300269 CDS YP_309211.1 74310792 3668341 207793..208350 1 NC_007384.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 208350 frr 3668341 frr Shigella sonnei Ss046 ribosome recycling factor YP_309211.1 207793 D 300269 CDS YP_309212.1 74310793 3668342 208442..209638 1 NC_007384.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 209638 yaeM 3668342 yaeM Shigella sonnei Ss046 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_309212.1 208442 D 300269 CDS YP_309213.1 74310794 3668343 209824..210585 1 NC_007384.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 210585 yaeS 3668343 yaeS Shigella sonnei Ss046 undecaprenyl pyrophosphate synthase YP_309213.1 209824 D 300269 CDS YP_309214.2 161986588 3668344 210598..211455 1 NC_007384.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 211455 cdsA 3668344 cdsA Shigella sonnei Ss046 CDP-diglyceride synthase YP_309214.2 210598 D 300269 CDS YP_309215.1 74310796 3668345 211467..212819 1 NC_007384.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 212819 yaeL 3668345 yaeL Shigella sonnei Ss046 zinc metallopeptidase RseP YP_309215.1 211467 D 300269 CDS YP_309216.1 74310797 3668346 212849..215281 1 NC_007384.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 215281 yaeT 3668346 yaeT Shigella sonnei Ss046 outer membrane protein assembly factor YaeT YP_309216.1 212849 D 300269 CDS YP_309217.1 74310798 3668347 215403..215888 1 NC_007384.1 located in outer membrane or nucleoid; Code: M; COG: COG2825; periplasmic chaperone 215888 hlpA 3668347 hlpA Shigella sonnei Ss046 periplasmic chaperone YP_309217.1 215403 D 300269 CDS YP_309218.1 74310799 3668348 215892..216917 1 NC_007384.1 third step of endotoxin (lipidA) synthesis; adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 216917 lpxD 3668348 lpxD Shigella sonnei Ss046 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_309218.1 215892 D 300269 CDS YP_309219.1 74310800 3668349 217022..217477 1 NC_007384.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 217477 fabZ 3668349 fabZ Shigella sonnei Ss046 (3R)-hydroxymyristoyl-ACP dehydratase YP_309219.1 217022 D 300269 CDS YP_309220.1 74310801 3668350 217481..218269 1 NC_007384.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 218269 lpxA 3668350 lpxA Shigella sonnei Ss046 UDP-N-acetylglucosamine acyltransferase YP_309220.1 217481 D 300269 CDS YP_309221.1 74310802 3668351 218269..219417 1 NC_007384.1 lipid A biosynthesis, penultimate step; catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 219417 lpxB 3668351 lpxB Shigella sonnei Ss046 lipid-A-disaccharide synthase YP_309221.1 218269 D 300269 CDS YP_309222.1 74310803 3668352 219414..220010 1 NC_007384.1 degrades RNA of DNA-RNA hybrids; RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 220010 rnhB 3668352 rnhB Shigella sonnei Ss046 ribonuclease HII YP_309222.1 219414 D 300269 CDS YP_309223.1 74310804 3668636 220047..223529 1 NC_007384.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 223529 dnaE 3668636 dnaE Shigella sonnei Ss046 DNA polymerase III subunit alpha YP_309223.1 220047 D 300269 CDS YP_309224.1 74310805 3668637 223542..224501 1 NC_007384.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 224501 accA 3668637 accA Shigella sonnei Ss046 acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_309224.1 223542 D 300269 CDS YP_309225.1 74310806 3668638 complement(224550..225896) 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 225896 3668638 SSON_0198 Shigella sonnei Ss046 IS4 orf YP_309225.1 224550 R 300269 CDS YP_309226.1 74310807 3668639 226039..228180 1 NC_007384.1 Code: E; COG: COG1982; lysine decarboxylase 2 228180 ldcC 3668639 ldcC Shigella sonnei Ss046 lysine decarboxylase 2 YP_309226.1 226039 D 300269 CDS YP_309227.2 161986587 3668640 228237..228626 1 NC_007384.1 Code: E; COG: COG0346; hypothetical protein 228626 yaeR 3668640 yaeR Shigella sonnei Ss046 hypothetical protein YP_309227.2 228237 D 300269 CDS YP_309228.1 74310809 3668641 228691..229989 1 NC_007384.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 229989 tilS 3668641 tilS Shigella sonnei Ss046 tRNA(Ile)-lysidine synthetase YP_309228.1 228691 D 300269 CDS YP_309229.1 74310810 3668642 complement(230038..230298) 1 NC_007384.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator 230298 yaeO 3668642 yaeO Shigella sonnei Ss046 Rho-binding antiterminator YP_309229.1 230038 R 300269 CDS YP_309230.1 74310811 3668643 complement(230285..230485) 1 NC_007384.1 hypothetical protein 230485 yaeP 3668643 yaeP Shigella sonnei Ss046 hypothetical protein YP_309230.1 230285 R 300269 CDS YP_309231.1 74310812 3668644 230651..231196 1 NC_007384.1 Code: S; COG: COG4681; hypothetical protein 231196 yaeQ 3668644 yaeQ Shigella sonnei Ss046 hypothetical protein YP_309231.1 230651 D 300269 CDS YP_309232.1 74310813 3668646 231628..232338 1 NC_007384.1 lipoprotein; Code: MP; COG: COG3015; copper homeostasis and adhesion lipoprotein 232338 cutF 3668646 cutF Shigella sonnei Ss046 copper homeostasis and adhesion lipoprotein YP_309232.1 231628 D 300269 CDS YP_309233.2 161986586 3668647 complement(232493..233317) 1 NC_007384.1 hypothetical protein 233317 yaeF 3668647 yaeF Shigella sonnei Ss046 hypothetical protein YP_309233.2 232493 R 300269 CDS YP_309234.1 74310815 3668648 complement(233370..235088) 1 NC_007384.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 235088 proS 3668648 proS Shigella sonnei Ss046 prolyl-tRNA synthetase YP_309234.1 233370 R 300269 CDS YP_309235.1 74310816 3668649 complement(235199..235906) 1 NC_007384.1 Code: S; COG: COG1720; hypothetical protein 235906 yaeB 3668649 yaeB Shigella sonnei Ss046 hypothetical protein YP_309235.1 235199 R 300269 CDS YP_309236.1 74310817 3668650 complement(235903..236307) 1 NC_007384.1 outer membrane lipoprotein 236307 rcsF 3668650 rcsF Shigella sonnei Ss046 outer membrane lipoprotein YP_309236.1 235903 R 300269 CDS YP_309237.1 74310818 3668651 complement(236425..237240) 1 NC_007384.1 Code: P; COG: COG1464; DL-methionine transporter substrate-binding subunit 237240 metQ 3668651 metQ Shigella sonnei Ss046 DL-methionine transporter substrate-binding subunit YP_309237.1 236425 R 300269 CDS YP_309238.1 74310819 3668652 complement(237280..237933) 1 NC_007384.1 part of the MetNIQ methionine uptake system; DL-methionine transporter permease 237933 yaeE 3668652 yaeE Shigella sonnei Ss046 DL-methionine transporter permease YP_309238.1 237280 R 300269 CDS YP_309239.1 74310820 3668653 complement(237926..238957) 1 NC_007384.1 part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit 238957 metN 3668653 metN Shigella sonnei Ss046 DL-methionine transporter ATP-binding subunit YP_309239.1 237926 R 300269 CDS YP_309240.1 74310821 3668654 239145..239720 1 NC_007384.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 239720 yaeD 3668654 yaeD Shigella sonnei Ss046 D,D-heptose 1,7-bisphosphate phosphatase YP_309240.1 239145 D 300269 CDS YP_309241.1 74310822 3668551 245604..246407 1 NC_007384.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 246407 dkgB 3668551 dkgB Shigella sonnei Ss046 2,5-diketo-D-gluconate reductase B YP_309241.1 245604 D 300269 CDS YP_309242.1 74310823 3668552 complement(246404..247318) 1 NC_007384.1 Code: K; COG: COG0583; LysR family transcriptional regulator 247318 yafC 3668552 yafC Shigella sonnei Ss046 LysR family transcriptional regulator YP_309242.1 246404 R 300269 CDS YP_309243.1 74310824 3668553 247559..248359 1 NC_007384.1 Code: S; COG: COG3021; hypothetical protein 248359 yafD 3668553 yafD Shigella sonnei Ss046 hypothetical protein YP_309243.1 247559 D 300269 CDS YP_309244.1 74310825 3668554 248363..248986 1 NC_007384.1 Code: QR; COG: COG0500; biotin synthesis protein 248986 yafE 3668554 yafE Shigella sonnei Ss046 biotin synthesis protein YP_309244.1 248363 D 300269 CDS YP_309245.1 74310826 3668555 complement(249035..250393) 1 NC_007384.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D 250393 mltD 3668555 mltD Shigella sonnei Ss046 membrane-bound lytic murein transglycosylase D YP_309245.1 249035 R 300269 CDS YP_309246.1 74310827 3668556 complement(250465..251220) 1 NC_007384.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase 251220 gloB 3668556 gloB Shigella sonnei Ss046 hydroxyacylglutathione hydrolase YP_309246.1 250465 R 300269 CDS YP_309247.1 74310828 3668557 251236..251976 1 NC_007384.1 Code: QR; COG: COG0500; hypothetical protein 251976 yafS 3668557 yafS Shigella sonnei Ss046 hypothetical protein YP_309247.1 251236 D 300269 CDS YP_309248.1 74310829 3668558 complement(251973..252440) 1 NC_007384.1 degrades RNA of DNA-RNA hybrids; participates in DNA replication; An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 252440 rnhA 3668558 rnhA Shigella sonnei Ss046 ribonuclease H YP_309248.1 251973 R 300269 CDS YP_309249.1 74310830 3668392 252505..253236 1 NC_007384.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 253236 dnaQ 3668392 dnaQ Shigella sonnei Ss046 DNA polymerase III subunit epsilon YP_309249.1 252505 D 300269 CDS YP_309250.1 74310831 3668394 253775..254560 1 NC_007384.1 aminopeptidase 254560 yafT 3668394 yafT Shigella sonnei Ss046 aminopeptidase YP_309250.1 253775 D 300269 CDS YP_309251.1 74310832 3668395 complement(255186..255524) 1 NC_007384.1 hypothetical protein 255524 yafU 3668395 yafU Shigella sonnei Ss046 hypothetical protein YP_309251.1 255186 R 300269 CDS YP_309252.1 74310833 3668396 complement(256165..256647) 1 NC_007384.1 Code: S; COG: COG3157; Hcp-like protein 256647 3668396 SSON_0233 Shigella sonnei Ss046 Hcp-like protein YP_309252.1 256165 R 300269 CDS YP_309253.1 74310834 3668397 complement(256671..258023) 1 NC_007384.1 Code: S; COG: COG3515; hypothetical protein 258023 3668397 SSON_0234 Shigella sonnei Ss046 hypothetical protein YP_309253.1 256671 R 300269 CDS YP_309254.1 74310835 3668398 complement(258034..258720) 1 NC_007384.1 hypothetical protein 258720 3668398 SSON_0235 Shigella sonnei Ss046 hypothetical protein YP_309254.1 258034 R 300269 CDS YP_309255.1 74310836 3668399 complement(258757..259932) 1 NC_007384.1 hypothetical protein 259932 3668399 SSON_0236 Shigella sonnei Ss046 hypothetical protein YP_309255.1 258757 R 300269 CDS YP_309256.2 161986585 3668400 complement(259945..260850) 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 260850 3668400 SSON_0237 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_309256.2 259945 R 300269 CDS YP_309257.1 74310838 3668401 complement(260808..261173) 1 NC_007384.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 261173 3668401 SSON_0238 Shigella sonnei Ss046 insertion sequence 2 OrfA protein YP_309257.1 260808 R 300269 CDS YP_309258.1 74310839 3668402 complement(261215..262894) 1 NC_007384.1 hypothetical protein 262894 3668402 SSON_0239 Shigella sonnei Ss046 hypothetical protein YP_309258.1 261215 R 300269 CDS YP_309259.1 74310840 3668403 complement(262913..264325) 1 NC_007384.1 Code: S; COG: COG3515; hypothetical protein 264325 3668403 SSON_0240 Shigella sonnei Ss046 hypothetical protein YP_309259.1 262913 R 300269 CDS YP_309260.1 74310841 3668404 complement(264330..265022) 1 NC_007384.1 hypothetical protein 265022 3668404 SSON_0241 Shigella sonnei Ss046 hypothetical protein YP_309260.1 264330 R 300269 CDS YP_309261.1 74310842 3668405 complement(265070..267529) 1 NC_007384.1 Code: O; COG: COG0542; ATP-dependent Clp proteinase ATP-binding protein 267529 3668405 SSON_0242 Shigella sonnei Ss046 ATP-dependent Clp proteinase ATP-binding protein YP_309261.1 265070 R 300269 CDS YP_309262.1 74310843 3668406 complement(267548..267847) 1 NC_007384.1 hypothetical protein 267847 3668406 SSON_0243 Shigella sonnei Ss046 hypothetical protein YP_309262.1 267548 R 300269 CDS YP_309263.1 74310844 3668407 complement(267856..268617) 1 NC_007384.1 Code: S; COG: COG3455; hypothetical protein 268617 3668407 SSON_0244 Shigella sonnei Ss046 hypothetical protein YP_309263.1 267856 R 300269 CDS YP_309264.1 74310845 3668408 complement(268622..269410) 1 NC_007384.1 Code: S; COG: COG3522; hypothetical protein 269410 3668408 SSON_0245 Shigella sonnei Ss046 hypothetical protein YP_309264.1 268622 R 300269 CDS YP_309265.1 74310846 3668409 complement(269403..269912) 1 NC_007384.1 hypothetical protein 269912 3668409 SSON_0246 Shigella sonnei Ss046 hypothetical protein YP_309265.1 269403 R 300269 CDS YP_309266.1 74310847 3668410 complement(269954..270478) 1 NC_007384.1 Code: S; COG: COG3521; lipoprotein 270478 3668410 SSON_0247 Shigella sonnei Ss046 lipoprotein YP_309266.1 269954 R 300269 CDS YP_309267.1 74310848 3669222 complement(270475..271755) 1 NC_007384.1 Code: T; COG: COG3456; hypothetical protein 271755 3669222 SSON_0248 Shigella sonnei Ss046 hypothetical protein YP_309267.1 270475 R 300269 CDS YP_309268.1 74310849 3669223 complement(271780..272862) 1 NC_007384.1 Code: S; COG: COG3520; hypothetical protein 272862 3669223 SSON_0249 Shigella sonnei Ss046 hypothetical protein YP_309268.1 271780 R 300269 CDS YP_309269.1 74310850 3669224 complement(272826..274676) 1 NC_007384.1 Code: S; COG: COG3519; hypothetical protein 274676 3669224 SSON_0250 Shigella sonnei Ss046 hypothetical protein YP_309269.1 272826 R 300269 CDS YP_309270.1 74310851 3669225 complement(275100..275648) 1 NC_007384.1 hypothetical protein 275648 3669225 SSON_0251 Shigella sonnei Ss046 hypothetical protein YP_309270.1 275100 R 300269 CDS YP_309271.1 74310852 3669226 complement(275685..276575) 1 NC_007384.1 Code: S; COG: COG3517; hypothetical protein 276575 3669226 SSON_0252 Shigella sonnei Ss046 hypothetical protein YP_309271.1 275685 R 300269 CDS YP_309272.1 74310853 3669227 complement(276626..276850) 1 NC_007384.1 hypothetical protein 276850 3669227 SSON_0253 Shigella sonnei Ss046 hypothetical protein YP_309272.1 276626 R 300269 CDS YP_309273.1 74310854 3669228 complement(276885..277385) 1 NC_007384.1 Code: S; COG: COG3516; hypothetical protein 277385 3669228 SSON_0254 Shigella sonnei Ss046 hypothetical protein YP_309273.1 276885 R 300269 CDS YP_309274.1 74310855 3669229 278082..278600 1 NC_007384.1 Code: S; COG: COG3157; hemolysin co-regulated protein 278600 3669229 SSON_0255 Shigella sonnei Ss046 hemolysin co-regulated protein YP_309274.1 278082 D 300269 CDS YP_309275.1 74310856 3669230 278810..280951 1 NC_007384.1 Code: S; COG: COG3501; Rhs element protein 280951 vgrG 3669230 vgrG Shigella sonnei Ss046 Rhs element protein YP_309275.1 278810 D 300269 CDS YP_309276.1 74310857 3669231 281027..285235 1 NC_007384.1 Code: M; COG: COG3209; rhs core protein with extension 285235 3669231 SSON_0257 Shigella sonnei Ss046 rhs core protein with extension YP_309276.1 281027 D 300269 CDS YP_309277.1 74310858 3669232 285247..285696 1 NC_007384.1 hypothetical protein 285696 3669232 SSON_0258 Shigella sonnei Ss046 hypothetical protein YP_309277.1 285247 D 300269 CDS YP_309278.1 74310859 3669233 286237..287094 1 NC_007384.1 Code: L; COG: COG5433; receptor protein 287094 ybfL 3669233 ybfL Shigella sonnei Ss046 receptor protein YP_309278.1 286237 D 300269 CDS YP_309279.1 74310860 3669234 288388..289524 1 NC_007384.1 Code: L; COG: COG5433; receptor 289524 yhhI 3669234 yhhI Shigella sonnei Ss046 receptor YP_309279.1 288388 D 300269 CDS YP_309280.1 74310861 3669235 complement(289566..290336) 1 NC_007384.1 Code: R; COG: COG0388; hypothetical protein 290336 yafV 3669235 yafV Shigella sonnei Ss046 hypothetical protein YP_309280.1 289566 R 300269 CDS YP_309281.1 74310862 3669236 290490..290963 1 NC_007384.1 inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 290963 ykfE 3669236 ykfE Shigella sonnei Ss046 C-lysozyme inhibitor YP_309281.1 290490 D 300269 CDS YP_309282.2 161986584 3669237 complement(291006..293450) 1 NC_007384.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase 293450 fadE 3669237 fadE Shigella sonnei Ss046 acyl-CoA dehydrogenase YP_309282.2 291006 R 300269 CDS YP_309283.1 74310864 3669238 293690..294268 1 NC_007384.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 294268 gmhA 3669238 gmhA Shigella sonnei Ss046 phosphoheptose isomerase YP_309283.1 293690 D 300269 CDS YP_309284.1 74310865 3669239 294474..295241 1 NC_007384.1 Code: R; COG: COG0121; amidotransferase 295241 yafJ 3669239 yafJ Shigella sonnei Ss046 amidotransferase YP_309284.1 294474 D 300269 CDS YP_309285.1 74310866 3669240 complement(295212..295952) 1 NC_007384.1 Code: S; COG: COG3034; hypothetical protein 295952 yafK 3669240 yafK Shigella sonnei Ss046 hypothetical protein YP_309285.1 295212 R 300269 CDS YP_309286.1 74310867 3669182 complement(296108..296386) 1 NC_007384.1 Code: S; COG: COG3041; hypothetical protein 296386 yafQ 3669182 yafQ Shigella sonnei Ss046 hypothetical protein YP_309286.1 296108 R 300269 CDS YP_309287.1 74310868 3669183 complement(296389..296649) 1 NC_007384.1 Code: L; COG: COG3077; damage-inducible protein J 296649 dinJ 3669183 dinJ Shigella sonnei Ss046 damage-inducible protein J YP_309287.1 296389 R 300269 CDS YP_309288.1 74310869 3669184 296859..297608 1 NC_007384.1 Code: M; COG: COG0791; lipoprotein 297608 yafL 3669184 yafL Shigella sonnei Ss046 lipoprotein YP_309288.1 296859 D 300269 CDS YP_309289.1 74310870 3669185 complement(297897..298400) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 298400 3669185 SSON_0270 Shigella sonnei Ss046 IS1 ORF YP_309289.1 297897 R 300269 CDS YP_309290.1 74310871 3669186 298848..299345 1 NC_007384.1 Code: L; COG: COG1943; hypothetical protein 299345 yafM 3669186 yafM Shigella sonnei Ss046 hypothetical protein YP_309290.1 298848 D 300269 CDS YP_309291.1 74310873 3669188 complement(299468..301207) 1 NC_007384.1 Code: NU; COG: COG1298; flagellar biosynthesis 301207 fhiA 3669188 fhiA Shigella sonnei Ss046 flagellar biosynthesis YP_309291.1 299468 R 300269 CDS YP_309292.1 74310872 3669187 301152..301937 1 NC_007384.1 Code: N; COG: COG1360; hypothetical protein 301937 mbhA 3669187 mbhA Shigella sonnei Ss046 hypothetical protein YP_309292.1 301152 D 300269 CDS YP_309293.1 74310874 3669189 302008..303063 1 NC_007384.1 tRNA synthetase; involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 303063 dinP 3669189 dinP Shigella sonnei Ss046 DNA polymerase IV YP_309293.1 302008 D 300269 CDS YP_309294.1 74310875 3669190 303060..303512 1 NC_007384.1 Code: KR; COG: COG0454; hypothetical protein 303512 yafP 3669190 yafP Shigella sonnei Ss046 hypothetical protein YP_309294.1 303060 D 300269 CDS YP_309295.1 74310876 3669192 complement(304303..305499) 1 NC_007384.1 Code: L; COG: COG3547; ISSfl2 ORF 305499 3669192 SSON_0277 Shigella sonnei Ss046 ISSfl2 ORF YP_309295.1 304303 R 300269 CDS YP_309296.1 74310877 3669193 306456..306956 1 NC_007384.1 similar to release factor 1 and 2; peptide chain release factor-like protein 306956 prfH 3669193 prfH Shigella sonnei Ss046 peptide chain release factor-like protein YP_309296.1 306456 D 300269 CDS YP_309297.1 74310878 3669194 complement(307013..308470) 1 NC_007384.1 peptidase D; Code: E; COG: COG2195; aminoacyl-histidine dipeptidase 308470 pepD 3669194 pepD Shigella sonnei Ss046 aminoacyl-histidine dipeptidase YP_309297.1 307013 R 300269 CDS YP_309298.1 74310879 3669195 308731..309189 1 NC_007384.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 309189 gpt 3669195 gpt Shigella sonnei Ss046 xanthine-guanine phosphoribosyltransferase YP_309298.1 308731 D 300269 CDS YP_309299.1 74310880 3669196 309281..310525 1 NC_007384.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 310525 frsA 3669196 frsA Shigella sonnei Ss046 fermentation/respiration switch protein YP_309299.1 309281 D 300269 CDS YP_309300.1 74310881 3669197 310583..310984 1 NC_007384.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 310984 crl 3669197 crl Shigella sonnei Ss046 DNA-binding transcriptional regulator Crl YP_309300.1 310583 D 300269 CDS YP_309301.1 74310882 3669198 complement(311023..312078) 1 NC_007384.1 Code: M; COG: COG3203; outer membrane phosphoporin protein E 312078 phoE 3669198 phoE Shigella sonnei Ss046 outer membrane phosphoporin protein E YP_309301.1 311023 R 300269 CDS YP_309302.1 74310883 3669199 312366..313469 1 NC_007384.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 313469 proB 3669199 proB Shigella sonnei Ss046 gamma-glutamyl kinase YP_309302.1 312366 D 300269 CDS YP_309303.1 74310884 3669200 313481..314734 1 NC_007384.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 314734 proA 3669200 proA Shigella sonnei Ss046 gamma-glutamyl phosphate reductase YP_309303.1 313481 D 300269 CDS YP_309304.1 74310885 3669097 complement(316680..317393) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 317393 3669097 SSON_0287 Shigella sonnei Ss046 IS600 ORF2 YP_309304.1 316680 R 300269 CDS YP_309305.1 74310886 3669098 complement(317534..317836) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 317836 3669098 SSON_0288 Shigella sonnei Ss046 IS600 ORF1 YP_309305.1 317534 R 300269 CDS YP_309306.1 74310887 3669099 318588..319619 1 NC_007384.1 Code: L; COG: COG3335; IS630 orf 319619 3669099 SSON_0289 Shigella sonnei Ss046 IS630 orf YP_309306.1 318588 D 300269 CDS YP_309307.1 74310888 3669100 320065..320568 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 320568 3669100 SSON_0290 Shigella sonnei Ss046 IS1 ORF YP_309307.1 320065 D 300269 CDS YP_309308.1 74310889 3669101 320570..321541 1 NC_007384.1 hypothetical protein 321541 3669101 SSON_0291 Shigella sonnei Ss046 hypothetical protein YP_309308.1 320570 D 300269 CDS YP_309309.1 74310890 3669102 321696..321998 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 321998 3669102 SSON_0292 Shigella sonnei Ss046 IS600 ORF1 YP_309309.1 321696 D 300269 CDS YP_309310.1 74310891 3669103 322139..322852 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 322852 3669103 SSON_0293 Shigella sonnei Ss046 IS600 ORF2 YP_309310.1 322139 D 300269 CDS YP_309311.1 74310892 3669105 complement(323274..324218) 1 NC_007384.1 catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family; 3-(2,3-dihydroxyphenyl)propionate dioxygenase 324218 mhpB 3669105 mhpB Shigella sonnei Ss046 3-(2,3-dihydroxyphenyl)propionate dioxygenase YP_309311.1 323274 R 300269 CDS YP_309312.1 74310893 3669107 complement(324220..325884) 1 NC_007384.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 325884 mhpA 3669107 mhpA Shigella sonnei Ss046 3-(3-hydroxyphenyl)propionate hydroxylase YP_309312.1 324220 R 300269 CDS YP_309313.1 74310894 3669108 326836..327918 1 NC_007384.1 transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor 327918 lacI 3669108 lacI Shigella sonnei Ss046 lac repressor YP_309313.1 326836 D 300269 CDS YP_309314.1 74310895 3669109 328041..331115 1 NC_007384.1 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon; beta-D-galactosidase 331115 lacZ 3669109 lacZ Shigella sonnei Ss046 beta-D-galactosidase YP_309314.1 328041 D 300269 CDS YP_309315.1 74310896 3669111 331686..332189 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 332189 3669111 SSON_0301 Shigella sonnei Ss046 IS1 ORF YP_309315.1 331686 D 300269 CDS YP_309316.1 74310897 3669112 332229..332861 1 NC_007384.1 Code: E; COG: COG1280; cytochrome subunit of dehydrogenase 332861 yahN 3669112 yahN Shigella sonnei Ss046 cytochrome subunit of dehydrogenase YP_309316.1 332229 D 300269 CDS YP_309317.1 74310898 3669113 complement(332878..333153) 1 NC_007384.1 hypothetical protein 333153 yahM 3669113 yahM Shigella sonnei Ss046 hypothetical protein YP_309317.1 332878 R 300269 CDS YP_309318.1 74310899 3669114 333438..333740 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 333740 3669114 SSON_0304 Shigella sonnei Ss046 IS600 ORF1 YP_309318.1 333438 D 300269 CDS YP_309319.1 74310900 3669022 333881..334594 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 334594 3669022 SSON_0305 Shigella sonnei Ss046 IS600 ORF2 YP_309319.1 333881 D 300269 CDS YP_309320.1 74310901 3669023 complement(334803..335618) 1 NC_007384.1 hypothetical protein 335618 yahL 3669023 yahL Shigella sonnei Ss046 hypothetical protein YP_309320.1 334803 R 300269 CDS YP_309321.1 74310902 3669024 complement(335861..336364) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 336364 3669024 SSON_0307 Shigella sonnei Ss046 IS1 ORF YP_309321.1 335861 R 300269 CDS YP_309322.1 74310903 3669025 complement(336638..337687) 1 NC_007384.1 Code: R; COG: COG1064; oxidoreductase 337687 yahK 3669025 yahK Shigella sonnei Ss046 oxidoreductase YP_309322.1 336638 R 300269 CDS YP_309323.1 74310904 3669026 complement(338064..339446) 1 NC_007384.1 metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain; deaminase 339446 yahJ 3669026 yahJ Shigella sonnei Ss046 deaminase YP_309323.1 338064 R 300269 CDS YP_309324.1 74310905 3669027 complement(339456..340406) 1 NC_007384.1 Code: E; COG: COG0549; carbamate kinase 340406 yahI 3669027 yahI Shigella sonnei Ss046 carbamate kinase YP_309324.1 339456 R 300269 CDS YP_309325.1 74310906 3669028 complement(340549..341907) 1 NC_007384.1 hypothetical protein 341907 yahG 3669028 yahG Shigella sonnei Ss046 hypothetical protein YP_309325.1 340549 R 300269 CDS YP_309326.1 74310907 3669029 complement(341907..343454) 1 NC_007384.1 Code: C; COG: COG0074; oxidoreductase subunit 343454 yahF 3669029 yahF Shigella sonnei Ss046 oxidoreductase subunit YP_309326.1 341907 R 300269 CDS YP_309327.1 74310908 3669030 complement(343444..344307) 1 NC_007384.1 hypothetical protein 344307 yahE 3669030 yahE Shigella sonnei Ss046 hypothetical protein YP_309327.1 343444 R 300269 CDS YP_309328.1 74310909 3669032 344839..345342 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 345342 3669032 SSON_0315 Shigella sonnei Ss046 IS1 ORF YP_309328.1 344839 D 300269 CDS YP_309329.1 74310910 3669033 complement(345462..346157) 1 NC_007384.1 Code: S; COG: COG1556; transporter 346157 ykgG 3669033 ykgG Shigella sonnei Ss046 transporter YP_309329.1 345462 R 300269 CDS YP_309330.1 74310911 3669034 complement(346150..347577) 1 NC_007384.1 Code: C; COG: COG1139; hypothetical protein 347577 ykgF 3669034 ykgF Shigella sonnei Ss046 hypothetical protein YP_309330.1 346150 R 300269 CDS YP_309331.1 74310912 3669035 complement(347588..348307) 1 NC_007384.1 Code: C; COG: COG0247; dehydrogenase subunit 348307 ykgE 3669035 ykgE Shigella sonnei Ss046 dehydrogenase subunit YP_309331.1 347588 R 300269 CDS YP_309332.1 74310913 3669036 complement(348835..349689) 1 NC_007384.1 Code: K; COG: COG2207; AraC family transcriptional regulator 349689 ykgD 3669036 ykgD Shigella sonnei Ss046 AraC family transcriptional regulator YP_309332.1 348835 R 300269 CDS YP_309333.2 161986583 3669037 349915..351240 1 NC_007384.1 Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 351240 ykgC 3669037 ykgC Shigella sonnei Ss046 pyridine nucleotide-disulfide oxidoreductase YP_309333.2 349915 D 300269 CDS YP_309334.1 74310915 3669038 351334..351585 1 NC_007384.1 hypothetical protein 351585 ykgI 3669038 ykgI Shigella sonnei Ss046 hypothetical protein YP_309334.1 351334 D 300269 CDS YP_309335.1 74310916 3669039 351588..352190 1 NC_007384.1 Code: S; COG: COG3059; hypothetical protein 352190 ykgB 3669039 ykgB Shigella sonnei Ss046 hypothetical protein YP_309335.1 351588 D 300269 CDS YP_309336.1 74310917 3669040 complement(352350..353186) 1 NC_007384.1 Code: R; COG: COG0656; dehydrogenase 353186 3669040 SSON_0323 Shigella sonnei Ss046 dehydrogenase YP_309336.1 352350 R 300269 CDS YP_309337.2 161986582 3669041 complement(353480..354385) 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 354385 3669041 SSON_0324 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_309337.2 353480 R 300269 CDS YP_309338.2 161986581 3668924 complement(354343..354708) 1 NC_007384.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 354708 3668924 SSON_0325 Shigella sonnei Ss046 insertion sequence 2 OrfA protein YP_309338.2 354343 R 300269 CDS YP_309339.1 74310920 3668925 complement(354753..355466) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 355466 3668925 SSON_0326 Shigella sonnei Ss046 IS600 ORF2 YP_309339.1 354753 R 300269 CDS YP_309340.1 74310921 3668926 complement(355607..355909) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 355909 3668926 SSON_0327 Shigella sonnei Ss046 IS600 ORF1 YP_309340.1 355607 R 300269 CDS YP_309341.2 161986580 3668928 356492..357301 1 NC_007384.1 catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid; 2-keto-4-pentenoate hydratase 357301 mhpD 3668928 mhpD Shigella sonnei Ss046 2-keto-4-pentenoate hydratase YP_309341.2 356492 D 300269 CDS YP_309342.1 74310923 3668929 357298..358248 1 NC_007384.1 catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 358248 mhpF 3668929 mhpF Shigella sonnei Ss046 acetaldehyde dehydrogenase YP_309342.1 357298 D 300269 CDS YP_309343.1 74310924 3668930 358245..359258 1 NC_007384.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 359258 mhpE 3668930 mhpE Shigella sonnei Ss046 4-hydroxy-2-ketovalerate aldolase YP_309343.1 358245 D 300269 CDS YP_309344.2 161986579 3668931 359545..360756 1 NC_007384.1 Code: GEPR; COG: COG0477; 3-hydroxyphenylpropionic transporter MhpT 360756 mhpT 3668931 mhpT Shigella sonnei Ss046 3-hydroxyphenylpropionic transporter MhpT YP_309344.2 359545 D 300269 CDS YP_309345.2 161986578 3668932 360858..361397 1 NC_007384.1 Code: S; COG: COG3122; nucleoprotein/polynucleotide-associated protein 361397 yaiL 3668932 yaiL Shigella sonnei Ss046 nucleoprotein/polynucleotide-associated protein YP_309345.2 360858 D 300269 CDS YP_309346.1 74310927 3668933 complement(361623..362456) 1 NC_007384.1 Code: R; COG: COG0627; esterase 362456 yaiM 3668933 yaiM Shigella sonnei Ss046 esterase YP_309346.1 361623 R 300269 CDS YP_309347.1 74310928 3668934 complement(362549..363658) 1 NC_007384.1 formaldehyde dehydrogenase, glutathione-dependent; Code: C; COG: COG1062; alcohol dehydrogenase 363658 adhC 3668934 adhC Shigella sonnei Ss046 alcohol dehydrogenase YP_309347.1 362549 R 300269 CDS YP_309348.1 74310929 3668935 complement(363693..363989) 1 NC_007384.1 formaldehyde-induced negative regulator of the frmRAB operon; regulator protein FrmR 363989 yaiN 3668935 yaiN Shigella sonnei Ss046 regulator protein FrmR YP_309348.1 363693 R 300269 CDS YP_309349.1 74310930 3668936 complement(364156..364929) 1 NC_007384.1 hypothetical protein 364929 yaiO 3668936 yaiO Shigella sonnei Ss046 hypothetical protein YP_309349.1 364156 R 300269 CDS YP_309350.1 74310931 3668937 complement(364931..365491) 1 NC_007384.1 Code: R; COG: COG0110; transferase 365491 3668937 SSON_0338 Shigella sonnei Ss046 transferase YP_309350.1 364931 R 300269 CDS YP_309351.1 74310932 3668939 complement(366697..367368) 1 NC_007384.1 Code: S; COG: COG2120; hypothetical protein 367368 yaiS 3668939 yaiS Shigella sonnei Ss046 hypothetical protein YP_309351.1 366697 R 300269 CDS YP_309352.2 161986577 3668940 complement(367868..368773) 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 368773 3668940 SSON_0341 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_309352.2 367868 R 300269 CDS YP_309353.1 74310934 3668941 complement(368731..369096) 1 NC_007384.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 369096 3668941 SSON_0342 Shigella sonnei Ss046 insertion sequence 2 OrfA protein YP_309353.1 368731 R 300269 CDS YP_309354.2 161986576 3668942 369314..370276 1 NC_007384.1 with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit 370276 tauA 3668942 tauA Shigella sonnei Ss046 taurine transporter substrate binding subunit YP_309354.2 369314 D 300269 CDS YP_309355.1 74310936 3668846 370289..371056 1 NC_007384.1 Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding subunit 371056 tauB 3668846 tauB Shigella sonnei Ss046 taurine transporter ATP-binding subunit YP_309355.1 370289 D 300269 CDS YP_309356.1 74310937 3668847 371053..371880 1 NC_007384.1 Code: P; COG: COG0600; taurine transporter subunit 371880 tauC 3668847 tauC Shigella sonnei Ss046 taurine transporter subunit YP_309356.1 371053 D 300269 CDS YP_309357.1 74310938 3668848 371877..372728 1 NC_007384.1 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase 372728 tauD 3668848 tauD Shigella sonnei Ss046 taurine dioxygenase YP_309357.1 371877 D 300269 CDS YP_309358.1 74310939 3668849 complement(372834..373841) 1 NC_007384.1 porphobilinogen synthase; catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 373841 hemB 3668849 hemB Shigella sonnei Ss046 delta-aminolevulinic acid dehydratase YP_309358.1 372834 R 300269 CDS YP_309359.1 74310940 3668850 complement(373978..374250) 1 NC_007384.1 hypothetical protein 374250 3668850 SSON_0348 Shigella sonnei Ss046 hypothetical protein YP_309359.1 373978 R 300269 CDS YP_309360.1 74310941 3668851 374335..377223 1 NC_007384.1 similar to 3rd module of ATP-binding components of transporters; Code: MU; COG: COG3468; flagellar protein 377223 yaiU 3668851 yaiU Shigella sonnei Ss046 flagellar protein YP_309360.1 374335 D 300269 CDS YP_309361.1 74310942 3668852 377266..377934 1 NC_007384.1 DNA-binding transcriptional regulator 377934 yaiV 3668852 yaiV Shigella sonnei Ss046 DNA-binding transcriptional regulator YP_309361.1 377266 D 300269 CDS YP_309362.1 74310943 3668853 complement(377935..379092) 1 NC_007384.1 this protein has no known enzymatic function; beta-lactam binding protein AmpH 379092 yaiH 3668853 yaiH Shigella sonnei Ss046 beta-lactam binding protein AmpH YP_309362.1 377935 R 300269 CDS YP_309363.1 74310944 3668854 379444..380664 1 NC_007384.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transporter 380664 sbmA 3668854 sbmA Shigella sonnei Ss046 transporter YP_309363.1 379444 D 300269 CDS YP_309364.1 74310945 3668855 380677..381771 1 NC_007384.1 hypothetical protein 381771 yaiW 3668855 yaiW Shigella sonnei Ss046 hypothetical protein YP_309364.1 380677 D 300269 CDS YP_309365.1 74310946 3668856 complement(381830..382138) 1 NC_007384.1 hypothetical protein 382138 3668856 SSON_0354 Shigella sonnei Ss046 hypothetical protein YP_309365.1 381830 R 300269 CDS YP_309366.1 74310947 3668857 382266..382610 1 NC_007384.1 hypothetical protein 382610 3668857 SSON_0355 Shigella sonnei Ss046 hypothetical protein YP_309366.1 382266 D 300269 CDS YP_309367.1 74310948 3668858 complement(382634..383728) 1 NC_007384.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 383728 ddl 3668858 ddl Shigella sonnei Ss046 D-alanyl-alanine synthetase A YP_309367.1 382634 R 300269 CDS YP_309368.1 74310949 3668859 384191..384451 1 NC_007384.1 hypothetical protein 384451 yaiB 3668859 yaiB Shigella sonnei Ss046 hypothetical protein YP_309368.1 384191 D 300269 CDS YP_309369.1 74310950 3668860 384483..385967 1 NC_007384.1 Code: P; COG: COG1785; alkaline phosphatase 385967 phoA 3668860 phoA Shigella sonnei Ss046 alkaline phosphatase YP_309369.1 384483 D 300269 CDS YP_309370.1 74310951 3668861 386068..386406 1 NC_007384.1 hypothetical protein 386406 psiF 3668861 psiF Shigella sonnei Ss046 hypothetical protein YP_309370.1 386068 D 300269 CDS YP_309371.1 74310952 3668862 386508..387359 1 NC_007384.1 hypothetical protein 387359 yaiC 3668862 yaiC Shigella sonnei Ss046 hypothetical protein YP_309371.1 386508 D 300269 CDS YP_309372.1 74310953 3668863 complement(387370..387873) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 387873 3668863 SSON_0361 Shigella sonnei Ss046 IS1 ORF YP_309372.1 387370 R 300269 CDS YP_309373.1 74310954 3668864 complement(388224..389033) 1 NC_007384.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 389033 proC 3668864 proC Shigella sonnei Ss046 pyrroline-5-carboxylate reductase YP_309373.1 388224 R 300269 CDS YP_309374.2 161986575 3668865 389153..389611 1 NC_007384.1 Code: S; COG: COG1671; hypothetical protein 389611 yaiI 3668865 yaiI Shigella sonnei Ss046 hypothetical protein YP_309374.2 389153 D 300269 CDS YP_309375.1 74310956 3668792 389794..390318 1 NC_007384.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 390318 aroL 3668792 aroL Shigella sonnei Ss046 shikimate kinase YP_309375.1 389794 D 300269 CDS YP_309376.1 74310957 3668793 390368..390559 1 NC_007384.1 hypothetical protein 390559 yaiA 3668793 yaiA Shigella sonnei Ss046 hypothetical protein YP_309376.1 390368 D 300269 CDS YP_309377.1 74310958 3668794 390817..391494 1 NC_007384.1 hypothetical protein 391494 aroM 3668794 aroM Shigella sonnei Ss046 hypothetical protein YP_309377.1 390817 D 300269 CDS YP_309378.1 74310959 3668795 391566..391850 1 NC_007384.1 Code: S; COG: COG3123; hypothetical protein 391850 yaiE 3668795 yaiE Shigella sonnei Ss046 hypothetical protein YP_309378.1 391566 D 300269 CDS YP_309379.1 74310960 3668796 391996..393342 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 393342 3668796 SSON_0368 Shigella sonnei Ss046 IS4 orf YP_309379.1 391996 D 300269 CDS YP_309380.1 74310961 3668797 393496..393777 1 NC_007384.1 hypothetical protein 393777 3668797 SSON_0369 Shigella sonnei Ss046 hypothetical protein YP_309380.1 393496 D 300269 CDS YP_309381.1 74310962 3668798 393774..394229 1 NC_007384.1 hypothetical protein 394229 3668798 SSON_0370 Shigella sonnei Ss046 hypothetical protein YP_309381.1 393774 D 300269 CDS YP_309382.1 74310964 3668800 complement(394307..395218) 1 NC_007384.1 Required for efficient pilin antigenic variation; recombination associated protein 395218 rdgC 3668800 rdgC Shigella sonnei Ss046 recombination associated protein YP_309382.1 394307 R 300269 CDS YP_309383.2 161986574 3668799 395343..396251 1 NC_007384.1 catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 396251 yajF 3668799 yajF Shigella sonnei Ss046 fructokinase YP_309383.2 395343 D 300269 CDS YP_309384.1 74310965 3668801 complement(396394..397578) 1 NC_007384.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ 397578 araJ 3668801 araJ Shigella sonnei Ss046 MFS transport protein AraJ YP_309384.1 396394 R 300269 CDS YP_309385.1 74310966 3668802 complement(397704..400847) 1 NC_007384.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease SbcC 400847 sbcC 3668802 sbcC Shigella sonnei Ss046 exonuclease SbcC YP_309385.1 397704 R 300269 CDS YP_309386.1 74310967 3668803 complement(400844..402046) 1 NC_007384.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease SbcD 402046 sbcD 3668803 sbcD Shigella sonnei Ss046 exonuclease SbcD YP_309386.1 400844 R 300269 CDS YP_309387.1 74310968 3668804 402236..402925 1 NC_007384.1 sensor is PhoR (or CreC); two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 402925 phoB 3668804 phoB Shigella sonnei Ss046 transcriptional regulator PhoB YP_309387.1 402236 D 300269 CDS YP_309388.1 74310969 3668805 402983..404278 1 NC_007384.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 404278 phoR 3668805 phoR Shigella sonnei Ss046 phosphate regulon sensor protein YP_309388.1 402983 D 300269 CDS YP_309389.1 74310970 3668806 404685..406004 1 NC_007384.1 Code: E; COG: COG1114; branched chain amino acid transport system II carrier protein 406004 brnQ 3668806 brnQ Shigella sonnei Ss046 branched chain amino acid transport system II carrier protein YP_309389.1 404685 D 300269 CDS YP_309390.1 74310971 3668807 406080..407453 1 NC_007384.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; proline-specific permease 407453 proY 3668807 proY Shigella sonnei Ss046 proline-specific permease YP_309390.1 406080 D 300269 CDS YP_309391.1 74310972 3668808 407609..409426 1 NC_007384.1 Code: G; COG: COG0366; maltodextrin glucosidase 409426 malZ 3668808 malZ Shigella sonnei Ss046 maltodextrin glucosidase YP_309391.1 407609 D 300269 CDS YP_309392.1 74310973 3668809 complement(409431..410012) 1 NC_007384.1 Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; ACP phosphodieterase 410012 yajB 3668809 yajB Shigella sonnei Ss046 ACP phosphodieterase YP_309392.1 409431 R 300269 CDS YP_309393.1 74310974 3668810 410105..411175 1 NC_007384.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 411175 queA 3668810 queA Shigella sonnei Ss046 S-adenosylmethionine--tRNA ribosyltransferase-isomerase YP_309393.1 410105 D 300269 CDS YP_309394.1 74310975 3668866 411231..412358 1 NC_007384.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 412358 tgt 3668866 tgt Shigella sonnei Ss046 queuine tRNA-ribosyltransferase YP_309394.1 411231 D 300269 CDS YP_309395.1 74310976 3668867 412381..412713 1 NC_007384.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 412713 yajC 3668867 yajC Shigella sonnei Ss046 preprotein translocase subunit YajC YP_309395.1 412381 D 300269 CDS YP_309396.1 74310977 3668868 412741..414588 1 NC_007384.1 protein secretion; membrane protein, part of the channel; part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 414588 secD 3668868 secD Shigella sonnei Ss046 preprotein translocase subunit SecD YP_309396.1 412741 D 300269 CDS YP_309397.1 74310978 3668869 414599..415570 1 NC_007384.1 protein secretion, membrane protein; forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 415570 secF 3668869 secF Shigella sonnei Ss046 preprotein translocase subunit SecF YP_309397.1 414599 D 300269 CDS YP_309398.1 74310979 3668870 415699..416046 1 NC_007384.1 Code: V; COG: COG1403; hypothetical protein 416046 yajD 3668870 yajD Shigella sonnei Ss046 hypothetical protein YP_309398.1 415699 D 300269 CDS YP_309399.1 74310980 3668871 complement(416223..417107) 1 NC_007384.1 receptor of phage T6 and colicin K; Code: M; COG: COG3248; nucleoside channel 417107 tsx 3668871 tsx Shigella sonnei Ss046 nucleoside channel YP_309399.1 416223 R 300269 CDS YP_309400.2 161986573 3668872 complement(417406..417945) 1 NC_007384.1 hypothetical protein 417945 yajI 3668872 yajI Shigella sonnei Ss046 hypothetical protein YP_309400.2 417406 R 300269 CDS YP_309401.1 74310982 3668873 418096..418545 1 NC_007384.1 Code: K; COG: COG1327; transcriptional regulator NrdR 418545 nrdR 3668873 nrdR Shigella sonnei Ss046 transcriptional regulator NrdR YP_309401.1 418096 D 300269 CDS YP_309402.1 74310983 3668874 418549..419652 1 NC_007384.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 419652 ribD 3668874 ribD Shigella sonnei Ss046 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase YP_309402.1 418549 D 300269 CDS YP_309403.1 74310984 3668875 419741..420211 1 NC_007384.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 420211 ribH 3668875 ribH Shigella sonnei Ss046 6,7-dimethyl-8-ribityllumazine synthase YP_309403.1 419741 D 300269 CDS YP_309404.1 74310985 3668876 420231..420650 1 NC_007384.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 420650 nusB 3668876 nusB Shigella sonnei Ss046 transcription antitermination protein NusB YP_309404.1 420231 D 300269 CDS YP_309405.1 74310986 3668877 420728..421705 1 NC_007384.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 421705 thiL 3668877 thiL Shigella sonnei Ss046 thiamine monophosphate kinase YP_309405.1 420728 D 300269 CDS YP_309406.1 74310987 3668878 421683..422201 1 NC_007384.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 422201 pgpA 3668878 pgpA Shigella sonnei Ss046 phosphatidylglycerophosphatase A YP_309406.1 421683 D 300269 CDS YP_309407.1 74310988 3668879 complement(422255..423229) 1 NC_007384.1 Code: C; COG: COG0667; NAD(P)H-dependent xylose reductase 423229 yajO 3668879 yajO Shigella sonnei Ss046 NAD(P)H-dependent xylose reductase YP_309407.1 422255 R 300269 CDS YP_309408.1 74310989 3668880 complement(423284..425146) 1 NC_007384.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 425146 dxs 3668880 dxs Shigella sonnei Ss046 1-deoxy-D-xylulose-5-phosphate synthase YP_309408.1 423284 R 300269 CDS YP_309409.1 74310990 3668881 complement(425171..426070) 1 NC_007384.1 farnesyldiphosphate synthase; Code: H; COG: COG0142; geranyltranstransferase 426070 ispA 3668881 ispA Shigella sonnei Ss046 geranyltranstransferase YP_309409.1 425171 R 300269 CDS YP_309410.1 74310991 3668882 complement(426070..426312) 1 NC_007384.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 426312 xseB 3668882 xseB Shigella sonnei Ss046 exodeoxyribonuclease VII small subunit YP_309410.1 426070 R 300269 CDS YP_309411.1 74310992 3668883 426518..427966 1 NC_007384.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 427966 yajK 3668883 yajK Shigella sonnei Ss046 thiamine biosynthesis protein ThiI YP_309411.1 426518 D 300269 CDS YP_309412.1 74310993 3668884 complement(428020..428616) 1 NC_007384.1 Code: R; COG: COG0693; DJ-1 family protein 428616 thiJ 3668884 thiJ Shigella sonnei Ss046 DJ-1 family protein YP_309412.1 428020 R 300269 CDS YP_309413.1 74310994 3668885 complement(428573..429484) 1 NC_007384.1 involved in thiamin biosynthesis, alternative pyrimidine biosynthesis; ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 429484 apbA 3668885 apbA Shigella sonnei Ss046 2-dehydropantoate 2-reductase YP_309413.1 428573 R 300269 CDS YP_309414.2 161986572 3667960 429652..430143 1 NC_007384.1 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein 430143 yajQ 3667960 yajQ Shigella sonnei Ss046 nucleotide-binding protein YP_309414.2 429652 D 300269 CDS YP_309415.1 74310996 3667961 complement(430271..431641) 1 NC_007384.1 Code: GEPR; COG: COG0477; transporter 431641 yajR 3667961 yajR Shigella sonnei Ss046 transporter YP_309415.1 430271 R 300269 CDS YP_309416.1 74310997 3667962 431948..432451 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 432451 3667962 SSON_0405 Shigella sonnei Ss046 IS1 ORF YP_309416.1 431948 D 300269 CDS YP_309417.1 74310998 3667963 432760..433224 1 NC_007384.1 hypothetical protein 433224 3667963 SSON_0406 Shigella sonnei Ss046 hypothetical protein YP_309417.1 432760 D 300269 CDS YP_309418.1 74310999 3667964 complement(433235..433738) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 433738 3667964 SSON_0407 Shigella sonnei Ss046 IS1 ORF YP_309418.1 433235 R 300269 CDS YP_309419.1 74311000 3667965 433990..434532 1 NC_007384.1 hypothetical protein 434532 3667965 SSON_0408 Shigella sonnei Ss046 hypothetical protein YP_309419.1 433990 D 300269 CDS YP_309420.1 74311001 3667966 complement(434588..435130) 1 NC_007384.1 acetyltransferase 435130 3667966 SSON_0409 Shigella sonnei Ss046 acetyltransferase YP_309420.1 434588 R 300269 CDS YP_309421.1 74311002 3667967 complement(435114..435473) 1 NC_007384.1 Code: S; COG: COG4453; hypothetical protein 435473 3667967 SSON_0410 Shigella sonnei Ss046 hypothetical protein YP_309421.1 435114 R 300269 CDS YP_309422.1 74311003 3667968 complement(435610..436500) 1 NC_007384.1 heme O biosynthesis; converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 436500 cyoE 3667968 cyoE Shigella sonnei Ss046 protoheme IX farnesyltransferase YP_309422.1 435610 R 300269 CDS YP_309423.1 74311004 3667969 complement(436512..436841) 1 NC_007384.1 Code: C; COG: COG3125; cytochrome o ubiquinol oxidase subunit IV 436841 cyoD 3667969 cyoD Shigella sonnei Ss046 cytochrome o ubiquinol oxidase subunit IV YP_309423.1 436512 R 300269 CDS YP_309424.1 74311005 3667970 complement(436841..437455) 1 NC_007384.1 Code: C; COG: COG1845; cytochrome o ubiquinol oxidase subunit III 437455 cyoC 3667970 cyoC Shigella sonnei Ss046 cytochrome o ubiquinol oxidase subunit III YP_309424.1 436841 R 300269 CDS YP_309425.1 74311006 3667971 complement(437445..439436) 1 NC_007384.1 Code: C; COG: COG0843; cytochrome o ubiquinol oxidase subunit I 439436 cyoB 3667971 cyoB Shigella sonnei Ss046 cytochrome o ubiquinol oxidase subunit I YP_309425.1 437445 R 300269 CDS YP_309426.1 74311007 3667972 complement(439458..440405) 1 NC_007384.1 Code: C; COG: COG1622; cytochrome o ubiquinol oxidase subunit II 440405 cyoA 3667972 cyoA Shigella sonnei Ss046 cytochrome o ubiquinol oxidase subunit II YP_309426.1 439458 R 300269 CDS YP_309427.1 74311008 3667973 complement(440867..442342) 1 NC_007384.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter 442342 ampG 3667973 ampG Shigella sonnei Ss046 muropeptide transporter YP_309427.1 440867 R 300269 CDS YP_309428.2 161986571 3667974 complement(442386..442964) 1 NC_007384.1 Code: M; COG: COG3056; hypothetical protein 442964 yajG 3667974 yajG Shigella sonnei Ss046 hypothetical protein YP_309428.2 442386 R 300269 CDS YP_309429.2 161986570 3667975 443269..443586 1 NC_007384.1 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA 443586 bolA 3667975 bolA Shigella sonnei Ss046 transcriptional regulator BolA YP_309429.2 443269 D 300269 CDS YP_309430.1 74311011 3667976 443930..445228 1 NC_007384.1 a molecular chaperone involved in cell division; Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 445228 tig 3667976 tig Shigella sonnei Ss046 trigger factor YP_309430.1 443930 D 300269 CDS YP_309431.1 74311012 3667977 445474..446097 1 NC_007384.1 heat shock protein F21.5; hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 446097 clpP 3667977 clpP Shigella sonnei Ss046 ATP-dependent Clp protease proteolytic subunit YP_309431.1 445474 D 300269 CDS YP_309432.1 74311013 3667978 446223..447497 1 NC_007384.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 447497 clpX 3667978 clpX Shigella sonnei Ss046 ATP-dependent protease ATP-binding subunit ClpX YP_309432.1 446223 D 300269 CDS YP_309433.1 74311014 3667920 447685..450039 1 NC_007384.1 heat shock K-protein; Code: O; COG: COG0466; DNA-binding ATP-dependent protease La 450039 lon 3667920 lon Shigella sonnei Ss046 DNA-binding ATP-dependent protease La YP_309433.1 447685 D 300269 CDS YP_309434.1 74311015 3667921 450248..450520 1 NC_007384.1 NS1; HU-1; histone-like DNA-binding protein; transcriptional regulator HU subunit beta 450520 hupB 3667921 hupB Shigella sonnei Ss046 transcriptional regulator HU subunit beta YP_309434.1 450248 D 300269 CDS YP_309435.1 74311016 3667922 450712..452583 1 NC_007384.1 Code: O; COG: COG0760; peptidyl-prolyl cis-trans isomerase 452583 ybaU 3667922 ybaU Shigella sonnei Ss046 peptidyl-prolyl cis-trans isomerase YP_309435.1 450712 D 300269 CDS YP_309436.1 74311017 3667923 452903..453205 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 453205 3667923 SSON_0425 Shigella sonnei Ss046 IS600 ORF1 YP_309436.1 452903 D 300269 CDS YP_309437.1 74311018 3667924 453346..453957 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 453957 3667924 SSON_0426 Shigella sonnei Ss046 IS600 ORF2 YP_309437.1 453346 D 300269 CDS YP_309438.1 74311019 3667925 complement(453917..454714) 1 NC_007384.1 Code: L; COG: COG1484; IS21 ORF2 454714 3667925 SSON_0427 Shigella sonnei Ss046 IS21 ORF2 YP_309438.1 453917 R 300269 CDS YP_309439.1 74311020 3667926 complement(454714..455886) 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 455886 3667926 SSON_0428 Shigella sonnei Ss046 IS21 ORF1 YP_309439.1 454714 R 300269 CDS YP_309440.1 74311021 3667927 455927..456193 1 NC_007384.1 IS600 ORF2 456193 3667927 SSON_0429 Shigella sonnei Ss046 IS600 ORF2 YP_309440.1 455927 D 300269 CDS YP_309441.1 74311022 3667928 456099..456506 1 NC_007384.1 Code: L; COG: COG1555; hypothetical protein 456506 ybaV 3667928 ybaV Shigella sonnei Ss046 hypothetical protein YP_309441.1 456099 D 300269 CDS YP_309442.1 74311023 3667929 456600..456998 1 NC_007384.1 Code: R; COG: COG0824; hypothetical protein 456998 ybaW 3667929 ybaW Shigella sonnei Ss046 hypothetical protein YP_309442.1 456600 D 300269 CDS YP_309443.1 74311024 3667930 complement(457050..457745) 1 NC_007384.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC 457745 ybaX 3667930 ybaX Shigella sonnei Ss046 queuosine biosynthesis protein QueC YP_309443.1 457050 R 300269 CDS YP_309444.1 74311025 3667931 complement(457810..459510) 1 NC_007384.1 Code: R; COG: COG4533; hypothetical protein 459510 ybaE 3667931 ybaE Shigella sonnei Ss046 hypothetical protein YP_309444.1 457810 R 300269 CDS YP_309445.1 74311026 3667932 459598..460428 1 NC_007384.1 Code: R; COG: COG0561; hypothetical protein 460428 cof 3667932 cof Shigella sonnei Ss046 hypothetical protein YP_309445.1 459598 D 300269 CDS YP_309446.1 74311027 3667933 460493..461038 1 NC_007384.1 Code: K; COG: COG1522; LRP-like transcriptional regulator 461038 ybaO 3667933 ybaO Shigella sonnei Ss046 LRP-like transcriptional regulator YP_309446.1 460493 D 300269 CDS YP_309447.1 74311028 3667934 461068..462840 1 NC_007384.1 Code: V; COG: COG1132; multidrug transporter membrane\ATP-binding proteins 462840 mdlA 3667934 mdlA Shigella sonnei Ss046 multidrug transporter membrane\ATP-binding proteins YP_309447.1 461068 D 300269 CDS YP_309448.1 74311029 3667935 462833..464614 1 NC_007384.1 Code: V; COG: COG1132; multidrug transporter membrane\ATP-binding proteins 464614 mdlB 3667935 mdlB Shigella sonnei Ss046 multidrug transporter membrane\ATP-binding proteins YP_309448.1 462833 D 300269 CDS YP_309449.1 74311030 3667936 464795..465133 1 NC_007384.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 465133 glnK 3667936 glnK Shigella sonnei Ss046 nitrogen regulatory protein P-II 2 YP_309449.1 464795 D 300269 CDS YP_309450.1 74311031 3667937 465163..466449 1 NC_007384.1 Code: P; COG: COG0004; ammonium transporter 466449 amtB 3667937 amtB Shigella sonnei Ss046 ammonium transporter YP_309450.1 465163 D 300269 CDS YP_309451.1 74311032 3667938 complement(466498..467358) 1 NC_007384.1 Code: I; COG: COG1946; acyl-CoA thioesterase 467358 tesB 3667938 tesB Shigella sonnei Ss046 acyl-CoA thioesterase YP_309451.1 466498 R 300269 CDS YP_309452.1 74311033 3667939 467576..468148 1 NC_007384.1 Code: S; COG: COG3126; glycoprotein-polysaccharide metabolism 468148 ybaY 3667939 ybaY Shigella sonnei Ss046 glycoprotein-polysaccharide metabolism YP_309452.1 467576 D 300269 CDS YP_309453.1 74311034 3666250 complement(468179..468568) 1 NC_007384.1 Code: L; COG: COG3695; hypothetical protein 468568 ybaZ 3666250 ybaZ Shigella sonnei Ss046 hypothetical protein YP_309453.1 468179 R 300269 CDS YP_309454.1 74311035 3666251 468869..469222 1 NC_007384.1 Code: S; COG: COG5507; hypothetical protein 469222 ybaA 3666251 ybaA Shigella sonnei Ss046 hypothetical protein YP_309454.1 468869 D 300269 CDS YP_309455.1 74311036 3666252 complement(469658..470818) 1 NC_007384.1 Code: T; COG: COG4943; hypothetical protein 470818 ylaB 3666252 ylaB Shigella sonnei Ss046 hypothetical protein YP_309455.1 469658 R 300269 CDS YP_309456.1 74311037 3666253 complement(470976..471485) 1 NC_007384.1 hypothetical protein 471485 ylaC 3666253 ylaC Shigella sonnei Ss046 hypothetical protein YP_309456.1 470976 R 300269 CDS YP_309457.1 74311038 3666254 complement(471562..472113) 1 NC_007384.1 Code: R; COG: COG0110; maltose O-acetyltransferase 472113 ylaD 3666254 ylaD Shigella sonnei Ss046 maltose O-acetyltransferase YP_309457.1 471562 R 300269 CDS YP_309458.1 74311039 3666255 complement(472284..472502) 1 NC_007384.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein 472502 hha 3666255 hha Shigella sonnei Ss046 hemolysin expression-modulating protein YP_309458.1 472284 R 300269 CDS YP_309459.1 74311040 3666256 complement(472528..472902) 1 NC_007384.1 hypothetical protein 472902 ybaJ 3666256 ybaJ Shigella sonnei Ss046 hypothetical protein YP_309459.1 472528 R 300269 CDS YP_309460.1 74311041 3666257 complement(473448..476597) 1 NC_007384.1 Code: V; COG: COG0841; acridine efflux pump 476597 acrB 3666257 acrB Shigella sonnei Ss046 acridine efflux pump YP_309460.1 473448 R 300269 CDS YP_309461.1 74311042 3666258 complement(476620..477813) 1 NC_007384.1 Code: M; COG: COG0845; acridine efflux pump 477813 acrA 3666258 acrA Shigella sonnei Ss046 acridine efflux pump YP_309461.1 476620 R 300269 CDS YP_309462.1 74311043 3666259 477955..478602 1 NC_007384.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR 478602 acrR 3666259 acrR Shigella sonnei Ss046 DNA-binding transcriptional repressor AcrR YP_309462.1 477955 D 300269 CDS YP_309463.1 74311044 3666260 478730..482092 1 NC_007384.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 482092 aefA 3666260 aefA Shigella sonnei Ss046 potassium efflux protein KefA YP_309463.1 478730 D 300269 CDS YP_309464.1 74311045 3666261 complement(482304..482465) 1 NC_007384.1 hypothetical protein 482465 ybaM 3666261 ybaM Shigella sonnei Ss046 hypothetical protein YP_309464.1 482304 R 300269 CDS YP_309465.1 74311046 3666262 complement(482479..483006) 1 NC_007384.1 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' 483006 priC 3666262 priC Shigella sonnei Ss046 primosomal replication protein N'' YP_309465.1 482479 R 300269 CDS YP_309466.1 74311047 3666263 483076..483453 1 NC_007384.1 Code: S; COG: COG2832; hypothetical protein 483453 ybaN 3666263 ybaN Shigella sonnei Ss046 hypothetical protein YP_309466.1 483076 D 300269 CDS YP_309467.1 74311048 3666264 483606..484157 1 NC_007384.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 484157 apt 3666264 apt Shigella sonnei Ss046 adenine phosphoribosyltransferase YP_309467.1 483606 D 300269 CDS YP_309468.1 74311049 3666265 484286..486211 1 NC_007384.1 DNA elongation factor III; catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 486211 dnaX 3666265 dnaX Shigella sonnei Ss046 DNA polymerase III subunits gamma and tau YP_309468.1 484286 D 300269 CDS YP_309469.1 74311050 3666266 486264..486593 1 NC_007384.1 Code: S; COG: COG0718; hypothetical protein 486593 ybaB 3666266 ybaB Shigella sonnei Ss046 hypothetical protein YP_309469.1 486264 D 300269 CDS YP_309470.1 74311051 3666267 486593..487198 1 NC_007384.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 487198 recR 3666267 recR Shigella sonnei Ss046 recombination protein RecR YP_309470.1 486593 D 300269 CDS YP_309471.1 74311052 3666268 487308..489182 1 NC_007384.1 heat shock protein C 62.5; molecular chaperone; heat shock protein 90 489182 htpG 3666268 htpG Shigella sonnei Ss046 heat shock protein 90 YP_309471.1 487308 D 300269 CDS YP_309472.1 74311053 3666404 489363..490007 1 NC_007384.1 pleiotropic effects on glycerol-3-phosphate acyltransferase activity; essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 490007 adk 3666404 adk Shigella sonnei Ss046 adenylate kinase YP_309472.1 489363 D 300269 CDS YP_309473.1 74311054 3666405 490139..491101 1 NC_007384.1 final enzyme of heme biosynthesis; protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 491101 hemH 3666405 hemH Shigella sonnei Ss046 ferrochelatase YP_309473.1 490139 D 300269 CDS YP_309474.1 74311055 3666406 complement(491098..492057) 1 NC_007384.1 Code: I; COG: COG0657; acetyl esterase 492057 ybaC 3666406 ybaC Shigella sonnei Ss046 acetyl esterase YP_309474.1 491098 R 300269 CDS YP_309475.1 74311056 3666407 492209..493513 1 NC_007384.1 Code: G; COG: COG0524; inosine-guanosine kinase 493513 gsk 3666407 gsk Shigella sonnei Ss046 inosine-guanosine kinase YP_309475.1 492209 D 300269 CDS YP_309476.1 74311057 3666408 complement(493646..495322) 1 NC_007384.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; cation:proton antiport protein 495322 ybaL 3666408 ybaL Shigella sonnei Ss046 cation:proton antiport protein YP_309476.1 493646 R 300269 CDS YP_309477.1 74311058 3666409 complement(495697..496410) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 496410 3666409 SSON_0466 Shigella sonnei Ss046 IS600 ORF2 YP_309477.1 495697 R 300269 CDS YP_309478.1 74311059 3666410 complement(496551..496853) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 496853 3666410 SSON_0467 Shigella sonnei Ss046 IS600 ORF1 YP_309478.1 496551 R 300269 CDS YP_309479.1 74311060 3666411 complement(496905..498047) 1 NC_007384.1 Code: GEPR; COG: COG0477; fosmidomycin resistance protein 498047 fsr 3666411 fsr Shigella sonnei Ss046 fosmidomycin resistance protein YP_309479.1 496905 R 300269 CDS YP_309480.1 74311061 3666412 498265..499917 1 NC_007384.1 5'-nucleotidase; catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase 499917 ushA 3666412 ushA Shigella sonnei Ss046 bifunctional UDP-sugar hydrolase/5'-nucleotidase YP_309480.1 498265 D 300269 CDS YP_309481.1 74311062 3666413 complement(499954..500433) 1 NC_007384.1 Code: S; COG: COG2606; hypothetical protein 500433 ybaK 3666413 ybaK Shigella sonnei Ss046 hypothetical protein YP_309481.1 499954 R 300269 CDS YP_309482.1 74311063 3666414 complement(500637..501431) 1 NC_007384.1 Code: S; COG: COG3735; ligase 501431 ybaP 3666414 ybaP Shigella sonnei Ss046 ligase YP_309482.1 500637 R 300269 CDS YP_309483.1 74311064 3666415 501515..501910 1 NC_007384.1 Code: R; COG: COG3093; hypothetical protein 501910 ybaQ 3666415 ybaQ Shigella sonnei Ss046 hypothetical protein YP_309483.1 501515 D 300269 CDS YP_309484.1 74311065 3666416 complement(502125..504629) 1 NC_007384.1 Code: P; COG: COG2217; copper exporting ATPase 504629 copA 3666416 copA Shigella sonnei Ss046 copper exporting ATPase YP_309484.1 502125 R 300269 CDS YP_309485.1 74311066 3666417 504891..505823 1 NC_007384.1 catalyzes the formation of glutamate from glutamine; glutaminase 505823 ybaS 3666417 ybaS Shigella sonnei Ss046 glutaminase YP_309485.1 504891 D 300269 CDS YP_309486.1 74311067 3666418 505826..507118 1 NC_007384.1 Code: E; COG: COG0531; amino acid/amine transport protein 507118 ybaT 3666418 ybaT Shigella sonnei Ss046 amino acid/amine transport protein YP_309486.1 505826 D 300269 CDS YP_309487.1 74311068 3666419 507243..507650 1 NC_007384.1 activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR 507650 ybbI 3666419 ybbI Shigella sonnei Ss046 DNA-binding transcriptional regulator CueR YP_309487.1 507243 D 300269 CDS YP_309488.1 74311069 3666420 complement(507651..508106) 1 NC_007384.1 Code: OU; COG: COG1585; hypothetical protein 508106 ybbJ 3666420 ybbJ Shigella sonnei Ss046 hypothetical protein YP_309488.1 507651 R 300269 CDS YP_309489.1 74311070 3666421 complement(508106..509023) 1 NC_007384.1 Code: O; COG: COG0330; protease 509023 ybbK 3666421 ybbK Shigella sonnei Ss046 protease YP_309489.1 508106 R 300269 CDS YP_309490.1 74311071 3666422 509169..509846 1 NC_007384.1 Code: R; COG: COG4619; ABC transporter ATP-binding protein 509846 ybbL 3666422 ybbL Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_309490.1 509169 D 300269 CDS YP_309491.1 74311072 3666423 509806..510612 1 NC_007384.1 Code: R; COG: COG0390; metal resistance protein 510612 ybbM 3666423 ybbM Shigella sonnei Ss046 metal resistance protein YP_309491.1 509806 D 300269 CDS YP_309492.1 74311073 3666308 complement(510675..511565) 1 NC_007384.1 Code: O; COG: COG3118; thioredoxin-like protein 511565 ybbN 3666308 ybbN Shigella sonnei Ss046 thioredoxin-like protein YP_309492.1 510675 R 300269 CDS YP_309493.1 74311074 3666309 complement(511590..512399) 1 NC_007384.1 Code: IQR; COG: COG1028; short chain dehydrogenase 512399 ybbO 3666309 ybbO Shigella sonnei Ss046 short chain dehydrogenase YP_309493.1 511590 R 300269 CDS YP_309494.1 74311076 3666311 complement(512389..513015) 1 NC_007384.1 also functions as protease I; Code: E; COG: COG2755; multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 513015 tesA 3666311 tesA Shigella sonnei Ss046 multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 YP_309494.1 512389 R 300269 CDS YP_309495.1 74311075 3666310 512983..513669 1 NC_007384.1 Code: Q; COG: COG4181; ABC transporter ATP-binding protein 513669 ybbA 3666310 ybbA Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_309495.1 512983 D 300269 CDS YP_309496.1 74311077 3666312 513666..516080 1 NC_007384.1 Code: Q; COG: COG3127; oxidoreductase 516080 ybbP 3666312 ybbP Shigella sonnei Ss046 oxidoreductase YP_309496.1 513666 D 300269 CDS YP_309497.1 74311078 3666313 complement(516314..517408) 1 NC_007384.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase 517408 ybbB 3666313 ybbB Shigella sonnei Ss046 tRNA 2-selenouridine synthase YP_309497.1 516314 R 300269 CDS YP_309498.1 74311079 3666315 complement(518583..519086) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 519086 3666315 SSON_0488 Shigella sonnei Ss046 IS1 ORF YP_309498.1 518583 R 300269 CDS YP_309499.1 74311080 3666316 519544..520410 1 NC_007384.1 5,10-methylene-tetrahydrofolate cyclohydrolase; catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 520410 folD 3666316 folD Shigella sonnei Ss046 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_309499.1 519544 D 300269 CDS YP_309500.2 161986569 3666317 520412..520624 1 NC_007384.1 Code: S; COG: COG2501; hypothetical protein 520624 ybcJ 3666317 ybcJ Shigella sonnei Ss046 hypothetical protein YP_309500.2 520412 D 300269 CDS YP_309501.1 74311082 3666318 520837..521253 1 NC_007384.1 Code: R; COG: COG1988; hypothetical protein 521253 ybcI 3666318 ybcI Shigella sonnei Ss046 hypothetical protein YP_309501.1 520837 D 300269 CDS YP_309502.1 74311083 3666319 complement(521289..522674) 1 NC_007384.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 522674 cysS 3666319 cysS Shigella sonnei Ss046 cysteinyl-tRNA synthetase YP_309502.1 521289 R 300269 CDS YP_309503.1 74311084 3666320 522848..523342 1 NC_007384.1 Code: O; COG: COG0652; peptidyl-prolyl cis-trans isomerase B 523342 ppiB 3666320 ppiB Shigella sonnei Ss046 peptidyl-prolyl cis-trans isomerase B YP_309503.1 522848 D 300269 CDS YP_309504.1 74311085 3666321 523345..524067 1 NC_007384.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 524067 ybbF 3666321 ybbF Shigella sonnei Ss046 UDP-2,3-diacylglucosamine hydrolase YP_309504.1 523345 D 300269 CDS YP_309505.1 74311086 3666322 524185..524694 1 NC_007384.1 AIR carboxylase, catalytic subunit; Code: F; COG: COG0041; phosphoribosylaminoimidazole carboxylase 524694 purE 3666322 purE Shigella sonnei Ss046 phosphoribosylaminoimidazole carboxylase YP_309505.1 524185 D 300269 CDS YP_309506.1 74311087 3666323 524691..525758 1 NC_007384.1 AIR carboxylase, CO(2)-fixing subunit; With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 525758 purK 3666323 purK Shigella sonnei Ss046 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_309506.1 524691 D 300269 CDS YP_309507.1 74311088 3666324 complement(525895..526788) 1 NC_007384.1 Code: E; COG: COG0549; carbamate kinase 526788 arcC 3666324 arcC Shigella sonnei Ss046 carbamate kinase YP_309507.1 525895 R 300269 CDS YP_309508.1 74311089 3666325 complement(526785..527438) 1 NC_007384.1 carboxylase 527438 ylbF 3666325 ylbF Shigella sonnei Ss046 carboxylase YP_309508.1 526785 R 300269 CDS YP_309509.1 74311090 3666326 complement(527449..528450) 1 NC_007384.1 hypothetical protein 528450 ylbE 3666326 ylbE Shigella sonnei Ss046 hypothetical protein YP_309509.1 527449 R 300269 CDS YP_309510.1 74311091 3666501 complement(528762..529265) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 529265 3666501 SSON_0500 Shigella sonnei Ss046 IS1 ORF YP_309510.1 528762 R 300269 CDS YP_309511.1 74311092 3666504 complement(531529..532380) 1 NC_007384.1 Code: G; COG: COG3622; hydroxypyruvate isomerase 532380 gip 3666504 gip Shigella sonnei Ss046 hydroxypyruvate isomerase YP_309511.1 531529 R 300269 CDS YP_309512.1 74311093 3666505 532819..533322 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 533322 3666505 SSON_0504 Shigella sonnei Ss046 IS1 ORF YP_309512.1 532819 D 300269 CDS YP_309513.1 74311094 3666507 535187..536164 1 NC_007384.1 Code: NU; COG: COG3539; fimbrial asembly protein 536164 sfmH 3666507 sfmH Shigella sonnei Ss046 fimbrial asembly protein YP_309513.1 535187 D 300269 CDS YP_309514.1 74311095 3666508 536175..536690 1 NC_007384.1 Code: NU; COG: COG3539; fimbrial protein 536690 sfmF 3666508 sfmF Shigella sonnei Ss046 fimbrial protein YP_309514.1 536175 D 300269 CDS YP_309515.2 161986568 3666509 537623..538528 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 538528 3666509 SSON_0508 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_309515.2 537623 D 300269 CDS YP_309516.1 74311097 3666510 complement(538633..539136) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 539136 3666510 SSON_0509 Shigella sonnei Ss046 IS1 ORF YP_309516.1 538633 R 300269 CDS YP_309517.1 74311098 3666513 complement(539802..540563) 1 NC_007384.1 thermoregulation of porin biosynthesis; Code: K; COG: COG2207; envelope protein 540563 envY 3666513 envY Shigella sonnei Ss046 envelope protein YP_309517.1 539802 R 300269 CDS YP_309518.1 74311099 3666514 complement(540746..541636) 1 NC_007384.1 hypothetical protein 541636 ybcH 3666514 ybcH Shigella sonnei Ss046 hypothetical protein YP_309518.1 540746 R 300269 CDS YP_309519.1 74311100 3666515 complement(541637..544609) 1 NC_007384.1 Code: R; COG: COG0457; bacteriophage N4 receptor, outer membrane subunit 544609 nfrA 3666515 nfrA Shigella sonnei Ss046 bacteriophage N4 receptor, outer membrane subunit YP_309519.1 541637 R 300269 CDS YP_309520.1 74311101 3666517 complement(545343..545846) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 545846 3666517 SSON_0516 Shigella sonnei Ss046 IS1 ORF YP_309520.1 545343 R 300269 CDS YP_309521.1 74311102 3666518 complement(546074..549505) 1 NC_007384.1 Code: M; COG: COG3209; rhs core protein with extension 549505 3666518 SSON_0517 Shigella sonnei Ss046 rhs core protein with extension YP_309521.1 546074 R 300269 CDS YP_309522.1 74311103 3666519 complement(549478..550563) 1 NC_007384.1 hypothetical protein 550563 3666519 SSON_0518 Shigella sonnei Ss046 hypothetical protein YP_309522.1 549478 R 300269 CDS YP_309523.1 74311104 3667582 complement(550637..551098) 1 NC_007384.1 Code: S; COG: COG5435; hypothetical protein 551098 3667582 SSON_0519 Shigella sonnei Ss046 hypothetical protein YP_309523.1 550637 R 300269 CDS YP_309524.1 74311105 3667583 complement(551126..553027) 1 NC_007384.1 Code: S; COG: COG3501; Vgr protein 553027 3667583 SSON_0520 Shigella sonnei Ss046 Vgr protein YP_309524.1 551126 R 300269 CDS YP_309525.1 74311106 3667584 complement(553764..555212) 1 NC_007384.1 Code: T; COG: COG0642; sensor kinase CusS 555212 ybcZ 3667584 ybcZ Shigella sonnei Ss046 sensor kinase CusS YP_309525.1 553764 R 300269 CDS YP_309526.1 74311107 3667585 complement(555202..555885) 1 NC_007384.1 response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR 555885 ylcA 3667585 ylcA Shigella sonnei Ss046 DNA-binding transcriptional activator CusR YP_309526.1 555202 R 300269 CDS YP_309527.1 74311108 3667586 556042..557424 1 NC_007384.1 with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 557424 ylcB 3667586 ylcB Shigella sonnei Ss046 copper/silver efflux system outer membrane protein CusC YP_309527.1 556042 D 300269 CDS YP_309528.1 74311109 3667587 557448..557780 1 NC_007384.1 Code: S; COG: COG5569; copper-binding protein 557780 ylcC 3667587 ylcC Shigella sonnei Ss046 copper-binding protein YP_309528.1 557448 D 300269 CDS YP_309529.1 74311110 3667588 557796..559019 1 NC_007384.1 with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB 559019 ylcD 3667588 ylcD Shigella sonnei Ss046 copper/silver efflux system membrane fusion protein CusB YP_309529.1 557796 D 300269 CDS YP_309530.1 74311111 3667589 559031..562174 1 NC_007384.1 Code: P; COG: COG3696; inner membrane component for iron transport 562174 ybdE 3667589 ybdE Shigella sonnei Ss046 inner membrane component for iron transport YP_309530.1 559031 D 300269 CDS YP_309531.1 74311112 3667590 562276..563652 1 NC_007384.1 Code: E; COG: COG1113; phenylalanine transporter 563652 pheP 3667590 pheP Shigella sonnei Ss046 phenylalanine transporter YP_309531.1 562276 D 300269 CDS YP_309532.1 74311113 3667591 complement(563720..564967) 1 NC_007384.1 Code: M; COG: COG0668; transport 564967 ybdG 3667591 ybdG Shigella sonnei Ss046 transport YP_309532.1 563720 R 300269 CDS YP_309533.1 74311114 3667592 complement(565075..565728) 1 NC_007384.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase 565728 nfnB 3667592 nfnB Shigella sonnei Ss046 dihydropteridine reductase YP_309533.1 565075 R 300269 CDS YP_309534.1 74311115 3667593 complement(565822..566190) 1 NC_007384.1 Code: S; COG: COG2315; hypothetical protein 566190 ybdF 3667593 ybdF Shigella sonnei Ss046 hypothetical protein YP_309534.1 565822 R 300269 CDS YP_309535.1 74311116 3667595 complement(566569..567687) 1 NC_007384.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase 567687 ybdK 3667595 ybdK Shigella sonnei Ss046 carboxylate-amine ligase YP_309535.1 566569 R 300269 CDS YP_309536.1 74311117 3667596 complement(568904..569533) 1 NC_007384.1 Code: Q; COG: COG2977; enterobactin synthase multienzyme complex phosphopantetheinyltransferase 569533 entD 3667596 entD Shigella sonnei Ss046 enterobactin synthase multienzyme complex phosphopantetheinyltransferase YP_309536.1 568904 R 300269 CDS YP_309537.1 74311118 3667597 complement(569699..571939) 1 NC_007384.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA 571939 fepA 3667597 fepA Shigella sonnei Ss046 outer membrane receptor FepA YP_309537.1 569699 R 300269 CDS YP_309538.1 74311119 3667598 572260..573384 1 NC_007384.1 Code: P; COG: COG2382; enterobactin/ferric enterobactin esterase 573384 fes 3667598 fes Shigella sonnei Ss046 enterobactin/ferric enterobactin esterase YP_309538.1 572260 D 300269 CDS YP_309539.1 74311120 3667599 573387..573605 1 NC_007384.1 Code: S; COG: COG3251; hypothetical protein 573605 ybdZ 3667599 ybdZ Shigella sonnei Ss046 hypothetical protein YP_309539.1 573387 D 300269 CDS YP_309540.1 74311121 3667600 573602..577483 1 NC_007384.1 may be part of enterobactin synthase as component F; with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 577483 entF 3667600 entF Shigella sonnei Ss046 enterobactin synthase subunit F YP_309540.1 573602 D 300269 CDS YP_309541.1 74311122 3667672 577699..578832 1 NC_007384.1 enterochelin transport; part of the ferric enterobactin transport system; necessary for enetrobactin uptake; ferric enterobactin transport protein FepE 578832 fepE 3667672 fepE Shigella sonnei Ss046 ferric enterobactin transport protein FepE YP_309541.1 577699 D 300269 CDS YP_309542.1 74311123 3667673 complement(578829..579644) 1 NC_007384.1 with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein 579644 fepC 3667673 fepC Shigella sonnei Ss046 iron-enterobactin transporter ATP-binding protein YP_309542.1 578829 R 300269 CDS YP_309543.1 74311124 3667674 complement(579641..580633) 1 NC_007384.1 with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease 580633 fepG 3667674 fepG Shigella sonnei Ss046 iron-enterobactin transporter permease YP_309543.1 579641 R 300269 CDS YP_309544.1 74311125 3667675 complement(580630..581634) 1 NC_007384.1 with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein 581634 fepD 3667675 fepD Shigella sonnei Ss046 iron-enterobactin transporter membrane protein YP_309544.1 580630 R 300269 CDS YP_309545.1 74311126 3667676 581745..582995 1 NC_007384.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 582995 ybdA 3667676 ybdA Shigella sonnei Ss046 enterobactin exporter EntS YP_309545.1 581745 D 300269 CDS YP_309546.1 74311127 3667677 complement(583076..584041) 1 NC_007384.1 enterochelin binding protein; with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein 584041 fepB 3667677 fepB Shigella sonnei Ss046 iron-enterobactin transporter periplasmic binding protein YP_309546.1 583076 R 300269 CDS YP_309547.1 74311128 3667678 584416..585591 1 NC_007384.1 enterochelin biosynthesis; Code: HQ; COG: COG1169; isochorismate hydroxymutase 585591 entC 3667678 entC Shigella sonnei Ss046 isochorismate hydroxymutase YP_309547.1 584416 D 300269 CDS YP_309548.1 74311129 3667679 585601..587211 1 NC_007384.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 587211 entE 3667679 entE Shigella sonnei Ss046 enterobactin synthase subunit E YP_309548.1 585601 D 300269 CDS YP_309549.1 74311130 3667680 587225..588082 1 NC_007384.1 isochroismatase; Code: Q; COG: COG1535; 2,3-dihydro-2,3-dihydroxybenzoate synthetase 588082 entB 3667680 entB Shigella sonnei Ss046 2,3-dihydro-2,3-dihydroxybenzoate synthetase YP_309549.1 587225 D 300269 CDS YP_309550.1 74311131 3667681 588082..588828 1 NC_007384.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 588828 entA 3667681 entA Shigella sonnei Ss046 2,3-dihydroxybenzoate-2,3-dehydrogenase YP_309550.1 588082 D 300269 CDS YP_309551.1 74311132 3667682 588831..589244 1 NC_007384.1 Code: Q; COG: COG2050; hypothetical protein 589244 ybdB 3667682 ybdB Shigella sonnei Ss046 hypothetical protein YP_309551.1 588831 D 300269 CDS YP_309552.1 74311133 3667683 589425..591530 1 NC_007384.1 Code: T; COG: COG1966; carbon starvation protein 591530 cstA 3667683 cstA Shigella sonnei Ss046 carbon starvation protein YP_309552.1 589425 D 300269 CDS YP_309553.1 74311134 3667684 591712..591909 1 NC_007384.1 Code: S; COG: COG2879; hypothetical protein 591909 ybdD 3667684 ybdD Shigella sonnei Ss046 hypothetical protein YP_309553.1 591712 D 300269 CDS YP_309554.1 74311135 3667685 complement(591919..593007) 1 NC_007384.1 member of the iron-containing alcohol dehydrogenase family; unknown function; hypothetical protein 593007 ybdH 3667685 ybdH Shigella sonnei Ss046 hypothetical protein YP_309554.1 591919 R 300269 CDS YP_309555.1 74311136 3667686 593116..594276 1 NC_007384.1 catalyzes the transfer of an amino moiety; aminotransferase 594276 ybdL 3667686 ybdL Shigella sonnei Ss046 aminotransferase YP_309555.1 593116 D 300269 CDS YP_309556.1 74311137 3667687 complement(594277..594906) 1 NC_007384.1 Code: K; COG: COG1475; hypothetical protein 594906 ybdM 3667687 ybdM Shigella sonnei Ss046 hypothetical protein YP_309556.1 594277 R 300269 CDS YP_309557.1 74311138 3667689 596395..596898 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 596898 3667689 SSON_0555 Shigella sonnei Ss046 IS1 ORF YP_309557.1 596395 D 300269 CDS YP_309558.1 74311139 3667690 complement(596892..597650) 1 NC_007384.1 Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase 597650 dsbG 3667690 dsbG Shigella sonnei Ss046 disulfide isomerase/thiol-disulfide oxidase YP_309558.1 596892 R 300269 CDS YP_309559.1 74311140 3667691 598022..598585 1 NC_007384.1 detoxification of hydroperoxides; with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase 598585 ahpC 3667691 ahpC Shigella sonnei Ss046 alkyl hydroperoxide reductase YP_309559.1 598022 D 300269 CDS YP_309560.1 74311141 3667750 598726..600321 1 NC_007384.1 detoxification of hydroperoxides; Code: O; COG: COG3634; alkyl hydroperoxide reductase 600321 ahpF 3667750 ahpF Shigella sonnei Ss046 alkyl hydroperoxide reductase YP_309560.1 598726 D 300269 CDS YP_309561.1 74311142 3667751 complement(600442..600870) 1 NC_007384.1 Code: T; COG: COG0589; hypothetical protein 600870 ybdQ 3667751 ybdQ Shigella sonnei Ss046 hypothetical protein YP_309561.1 600442 R 300269 CDS YP_309562.1 74311143 3667752 601091..602329 1 NC_007384.1 Code: ER; COG: COG1063; oxidoreductase 602329 ybdR 3667752 ybdR Shigella sonnei Ss046 oxidoreductase YP_309562.1 601091 D 300269 CDS YP_309563.1 74311144 3667753 602410..602871 1 NC_007384.1 hypothetical protein 602871 3667753 SSON_0561 Shigella sonnei Ss046 hypothetical protein YP_309563.1 602410 D 300269 CDS YP_309564.1 74311145 3667754 complement(602560..602970) 1 NC_007384.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator 602970 rnk 3667754 rnk Shigella sonnei Ss046 nucleoside diphosphate kinase regulator YP_309564.1 602560 R 300269 CDS YP_309565.1 74311146 3667755 complement(603200..604006) 1 NC_007384.1 cleaves phosphodiester bond between any two nucleotides; Code: J; COG: COG3719; ribonuclease I 604006 rna 3667755 rna Shigella sonnei Ss046 ribonuclease I YP_309565.1 603200 R 300269 CDS YP_309566.1 74311147 3667756 complement(604120..605583) 1 NC_007384.1 Code: P; COG: COG0471; hypothetical protein 605583 ybdS 3667756 ybdS Shigella sonnei Ss046 hypothetical protein YP_309566.1 604120 R 300269 CDS YP_309567.1 74311148 3667757 complement(605634..606512) 1 NC_007384.1 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase 606512 citG 3667757 citG Shigella sonnei Ss046 triphosphoribosyl-dephospho-CoA synthase YP_309567.1 605634 R 300269 CDS YP_309568.1 74311149 3667758 complement(606487..607038) 1 NC_007384.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase 607038 citX 3667758 citX Shigella sonnei Ss046 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase YP_309568.1 606487 R 300269 CDS YP_309569.1 74311150 3667759 complement(607042..608574) 1 NC_007384.1 Code: C; COG: COG3051; citrate lyase subunit alpha 608574 citF 3667759 citF Shigella sonnei Ss046 citrate lyase subunit alpha YP_309569.1 607042 R 300269 CDS YP_309570.1 74311151 3667760 complement(608585..609508) 1 NC_007384.1 Code: G; COG: COG2301; citrate lyase subunit beta; acyl lyase subunit 609508 citE 3667760 citE Shigella sonnei Ss046 citrate lyase subunit beta; acyl lyase subunit YP_309570.1 608585 R 300269 CDS YP_309571.1 74311152 3667761 complement(609490..609786) 1 NC_007384.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma 609786 citD 3667761 citD Shigella sonnei Ss046 citrate lyase subunit gamma YP_309571.1 609490 R 300269 CDS YP_309572.1 74311153 3667762 complement(610717..611220) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 611220 3667762 SSON_0570 Shigella sonnei Ss046 IS1 ORF YP_309572.1 610717 R 300269 CDS YP_309573.1 74311154 3667764 612015..613673 1 NC_007384.1 Code: T; COG: COG3290; sensor-type protein 613673 citA 3667764 citA Shigella sonnei Ss046 sensor-type protein YP_309573.1 612015 D 300269 CDS YP_309574.1 74311155 3667765 613642..614322 1 NC_007384.1 regulates the expression of citAB in citrate fermentation; two-component response regulator DpiA 614322 dpiA 3667765 dpiA Shigella sonnei Ss046 two-component response regulator DpiA YP_309574.1 613642 D 300269 CDS YP_309575.1 74311156 3667766 complement(614363..615706) 1 NC_007384.1 responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC 615706 dcuC 3667766 dcuC Shigella sonnei Ss046 C4-dicarboxylate transporter DcuC YP_309575.1 614363 R 300269 CDS YP_309576.1 74311157 3667767 615974..616477 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 616477 3667767 SSON_0575 Shigella sonnei Ss046 IS1 ORF YP_309576.1 615974 D 300269 CDS YP_309577.1 74311158 3667768 616479..616961 1 NC_007384.1 catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 616961 pagP 3667768 pagP Shigella sonnei Ss046 palmitoyl transferase YP_309577.1 616479 D 300269 CDS YP_309578.1 74311159 3667542 617136..617345 1 NC_007384.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 617345 cspE 3667542 cspE Shigella sonnei Ss046 cold shock protein CspE YP_309578.1 617136 D 300269 CDS YP_309579.1 74311160 3667543 complement(617399..617782) 1 NC_007384.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 617782 crcB 3667543 crcB Shigella sonnei Ss046 camphor resistance protein CrcB YP_309579.1 617399 R 300269 CDS YP_309580.1 74311161 3667544 618100..618663 1 NC_007384.1 Code: R; COG: COG0388; amidase 618663 ybeM 3667544 ybeM Shigella sonnei Ss046 amidase YP_309580.1 618100 D 300269 CDS YP_309581.1 74311162 3667545 618792..618995 1 NC_007384.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein E 618995 tatE 3667545 tatE Shigella sonnei Ss046 twin arginine translocase protein E YP_309581.1 618792 D 300269 CDS YP_309582.1 74311163 3667546 complement(619070..620416) 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 620416 3667546 SSON_0581 Shigella sonnei Ss046 IS4 orf YP_309582.1 619070 R 300269 CDS YP_309583.1 74311164 3667547 complement(620533..621498) 1 NC_007384.1 lipoate synthesis, possibly involved in sulfur insertion; catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 621498 lipA 3667547 lipA Shigella sonnei Ss046 lipoyl synthase YP_309583.1 620533 R 300269 CDS YP_309584.1 74311165 3667548 complement(621707..622507) 1 NC_007384.1 Code: K; COG: COG0583; DNA-binding transcriptional regulator 622507 ybeF 3667548 ybeF Shigella sonnei Ss046 DNA-binding transcriptional regulator YP_309584.1 621707 R 300269 CDS YP_309585.2 161986567 3667549 complement(622920..623561) 1 NC_007384.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 623561 lipB 3667549 lipB Shigella sonnei Ss046 lipoate-protein ligase B YP_309585.2 622920 R 300269 CDS YP_309586.1 74311167 3667550 complement(623662..623925) 1 NC_007384.1 Code: S; COG: COG2921; hypothetical protein 623925 ybeD 3667550 ybeD Shigella sonnei Ss046 hypothetical protein YP_309586.1 623662 R 300269 CDS YP_309587.1 74311168 3667551 complement(624035..625246) 1 NC_007384.1 penicillin-binding protein 5; penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase 625246 dacA 3667551 dacA Shigella sonnei Ss046 D-alanyl-D-alanine carboxypeptidase YP_309587.1 624035 R 300269 CDS YP_309588.1 74311169 3667552 complement(625385..626473) 1 NC_007384.1 Code: M; COG: COG0797; rare lipoprotein A 626473 rlpA 3667552 rlpA Shigella sonnei Ss046 rare lipoprotein A YP_309588.1 625385 R 300269 CDS YP_309589.1 74311170 3667553 complement(626484..627596) 1 NC_007384.1 sensitivity to radiation and drugs; Code: D; COG: COG0772; cell wall shape-determining protein 627596 mrdB 3667553 mrdB Shigella sonnei Ss046 cell wall shape-determining protein YP_309589.1 626484 R 300269 CDS YP_309590.1 74311171 3667554 complement(627599..629500) 1 NC_007384.1 cell elongation e phase; penicillin-binding protein 2; Code: M; COG: COG0768; penicillin-binding protein 2 629500 mrdA 3667554 mrdA Shigella sonnei Ss046 penicillin-binding protein 2 YP_309590.1 627599 R 300269 CDS YP_309591.1 74311172 3667555 complement(629531..629998) 1 NC_007384.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 629998 ybeA 3667555 ybeA Shigella sonnei Ss046 rRNA large subunit methyltransferase YP_309591.1 629531 R 300269 CDS YP_309592.1 74311173 3667556 complement(630002..630211) 1 NC_007384.1 Code: S; COG: COG0799; hypothetical protein 630211 ybeB 3667556 ybeB Shigella sonnei Ss046 hypothetical protein YP_309592.1 630002 R 300269 CDS YP_309593.1 74311174 3667557 complement(630666..631190) 1 NC_007384.1 Salmonella cobC-like protein; phosphohistidine protein; Code: G; COG: COG0406; protein PhpB 631190 phpB 3667557 phpB Shigella sonnei Ss046 protein PhpB YP_309593.1 630666 R 300269 CDS YP_309594.1 74311175 3667558 complement(631214..631855) 1 NC_007384.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 631855 nadD 3667558 nadD Shigella sonnei Ss046 nicotinic acid mononucleotide adenylyltransferase YP_309594.1 631214 R 300269 CDS YP_309595.1 74311176 3667559 complement(631857..632888) 1 NC_007384.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 632888 holA 3667559 holA Shigella sonnei Ss046 DNA polymerase III subunit delta YP_309595.1 631857 R 300269 CDS YP_309596.1 74311177 3667560 complement(632888..633469) 1 NC_007384.1 rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB 633469 rlpB 3667560 rlpB Shigella sonnei Ss046 LPS-assembly lipoprotein RlpB YP_309596.1 632888 R 300269 CDS YP_309597.1 74311178 3667561 complement(633484..636066) 1 NC_007384.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 636066 leuS 3667561 leuS Shigella sonnei Ss046 leucyl-tRNA synthetase YP_309597.1 633484 R 300269 CDS YP_309598.1 74311179 3666520 636301..636783 1 NC_007384.1 hypothetical protein 636783 ybeL 3666520 ybeL Shigella sonnei Ss046 hypothetical protein YP_309598.1 636301 D 300269 CDS YP_309599.1 74311180 3666521 complement(636853..637836) 1 NC_007384.1 Code: R; COG: COG0790; hypothetical protein 637836 ybeQ 3666521 ybeQ Shigella sonnei Ss046 hypothetical protein YP_309599.1 636853 R 300269 CDS YP_309600.1 74311181 3666522 637994..638701 1 NC_007384.1 hypothetical protein 638701 ybeR 3666522 ybeR Shigella sonnei Ss046 hypothetical protein YP_309600.1 637994 D 300269 CDS YP_309601.1 74311182 3666523 638698..640125 1 NC_007384.1 polynucleotide modification protein 640125 ybeS 3666523 ybeS Shigella sonnei Ss046 polynucleotide modification protein YP_309601.1 638698 D 300269 CDS YP_309602.1 74311183 3666524 complement(640135..640689) 1 NC_007384.1 Code: R; COG: COG0790; hypothetical protein 640689 ybeT 3666524 ybeT Shigella sonnei Ss046 hypothetical protein YP_309602.1 640135 R 300269 CDS YP_309603.1 74311184 3666525 640791..641498 1 NC_007384.1 tRNA ligase 641498 ybeU 3666525 ybeU Shigella sonnei Ss046 tRNA ligase YP_309603.1 640791 D 300269 CDS YP_309604.1 74311185 3666526 641495..642946 1 NC_007384.1 hypothetical protein 642946 ybeV 3666526 ybeV Shigella sonnei Ss046 hypothetical protein YP_309604.1 641495 D 300269 CDS YP_309605.1 74311186 3666527 complement(643006..644676) 1 NC_007384.1 Code: O; COG: COG0443; molecular chaperone DnaK 644676 ybeW 3666527 ybeW Shigella sonnei Ss046 molecular chaperone DnaK YP_309605.1 643006 R 300269 CDS YP_309606.1 74311187 3666528 complement(644768..645703) 1 NC_007384.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 645703 rihA 3666528 rihA Shigella sonnei Ss046 ribonucleoside hydrolase 1 YP_309606.1 644768 R 300269 CDS YP_309607.1 74311188 3666529 complement(645821..646546) 1 NC_007384.1 Code: E; COG: COG1126; glutamate/aspartate ABC transporter ATP-binding protein 646546 gltL 3666529 gltL Shigella sonnei Ss046 glutamate/aspartate ABC transporter ATP-binding protein YP_309607.1 645821 R 300269 CDS YP_309608.1 74311189 3666530 complement(646546..647220) 1 NC_007384.1 Code: E; COG: COG0765; glutamate/aspartate transport system permease 647220 gltK 3666530 gltK Shigella sonnei Ss046 glutamate/aspartate transport system permease YP_309608.1 646546 R 300269 CDS YP_309609.1 74311190 3666531 complement(647220..647960) 1 NC_007384.1 Code: E; COG: COG0765; glutamate/aspartate transport system permease 647960 gltJ 3666531 gltJ Shigella sonnei Ss046 glutamate/aspartate transport system permease YP_309609.1 647220 R 300269 CDS YP_309610.1 74311191 3666532 complement(648130..649038) 1 NC_007384.1 Code: ET; COG: COG0834; glutamate and aspartate transporter subunit 649038 ybeJ 3666532 ybeJ Shigella sonnei Ss046 glutamate and aspartate transporter subunit YP_309610.1 648130 R 300269 CDS YP_309611.1 74311192 3666533 649493..651370 1 NC_007384.1 hypothetical protein 651370 3666533 SSON_0610 Shigella sonnei Ss046 hypothetical protein YP_309611.1 649493 D 300269 CDS YP_309612.1 74311193 3666534 complement(651448..652986) 1 NC_007384.1 copper homeostasis protein, inner membrane; Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 652986 lnt 3666534 lnt Shigella sonnei Ss046 apolipoprotein N-acyltransferase YP_309612.1 651448 R 300269 CDS YP_309613.1 74311194 3666535 complement(653011..653889) 1 NC_007384.1 Code: P; COG: COG4535; transporter 653889 ybeX 3666535 ybeX Shigella sonnei Ss046 transporter YP_309613.1 653011 R 300269 CDS YP_309614.1 74311195 3666536 complement(653979..654446) 1 NC_007384.1 Code: R; COG: COG0319; metalloprotease 654446 ybeY 3666536 ybeY Shigella sonnei Ss046 metalloprotease YP_309614.1 653979 R 300269 CDS YP_309615.1 74311196 3666537 complement(654443..655522) 1 NC_007384.1 Code: T; COG: COG1702; ATP-binding protein in pho regulon 655522 ybeZ 3666537 ybeZ Shigella sonnei Ss046 ATP-binding protein in pho regulon YP_309615.1 654443 R 300269 CDS YP_309616.1 74311197 3666538 complement(655636..657060) 1 NC_007384.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 657060 yleA 3666538 yleA Shigella sonnei Ss046 (dimethylallyl)adenosine tRNA methylthiotransferase YP_309616.1 655636 R 300269 CDS YP_309617.1 74311198 3670733 657206..658381 1 NC_007384.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 658381 ubiF 3670733 ubiF Shigella sonnei Ss046 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase YP_309617.1 657206 D 300269 CDS YP_309620.1 74311201 3670744 complement(659617..661281) 1 NC_007384.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B 661281 asnB 3670744 asnB Shigella sonnei Ss046 asparagine synthetase B YP_309620.1 659617 R 300269 CDS YP_309621.1 74311202 3669681 661750..662253 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 662253 3669681 SSON_0628 Shigella sonnei Ss046 IS1 ORF YP_309621.1 661750 D 300269 CDS YP_309622.1 74311203 3669682 complement(662455..663207) 1 NC_007384.1 Code: G; COG: COG0647; UMP phosphatase 663207 nagD 3669682 nagD Shigella sonnei Ss046 UMP phosphatase YP_309622.1 662455 R 300269 CDS YP_309623.1 74311204 3669683 complement(663255..664475) 1 NC_007384.1 Code: KG; COG: COG1940; transcriptional repressor of nag (N-acetylglucosamine) operon 664475 nagC 3669683 nagC Shigella sonnei Ss046 transcriptional repressor of nag (N-acetylglucosamine) operon YP_309623.1 663255 R 300269 CDS YP_309624.1 74311205 3669684 complement(664484..665632) 1 NC_007384.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 665632 nagA 3669684 nagA Shigella sonnei Ss046 N-acetylglucosamine-6-phosphate deacetylase YP_309624.1 664484 R 300269 CDS YP_309625.1 74311206 3669685 complement(665692..666492) 1 NC_007384.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 666492 nagB 3669685 nagB Shigella sonnei Ss046 glucosamine-6-phosphate deaminase YP_309625.1 665692 R 300269 CDS YP_309626.1 74311207 3669686 666825..668771 1 NC_007384.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunit IIABC 668771 nagE 3669686 nagE Shigella sonnei Ss046 PTS system N-acetyl glucosamine specific transporter subunit IIABC YP_309626.1 666825 D 300269 CDS YP_309627.1 74311208 3669687 669030..670694 1 NC_007384.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 670694 glnS 3669687 glnS Shigella sonnei Ss046 glutaminyl-tRNA synthetase YP_309627.1 669030 D 300269 CDS YP_309628.1 74311209 3669688 671272..672441 1 NC_007384.1 hypothetical protein 672441 ybfM 3669688 ybfM Shigella sonnei Ss046 hypothetical protein YP_309628.1 671272 D 300269 CDS YP_309629.1 74311210 3669689 672728..673054 1 NC_007384.1 hypothetical protein 673054 ybfN 3669689 ybfN Shigella sonnei Ss046 hypothetical protein YP_309629.1 672728 D 300269 CDS YP_309630.1 74311211 3669690 complement(673139..673585) 1 NC_007384.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator 673585 fur 3669690 fur Shigella sonnei Ss046 ferric uptake regulator YP_309630.1 673139 R 300269 CDS YP_309631.1 74311212 3669691 complement(673874..674404) 1 NC_007384.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA 674404 fldA 3669691 fldA Shigella sonnei Ss046 flavodoxin FldA YP_309631.1 673874 R 300269 CDS YP_309632.1 74311213 3669692 complement(674544..674906) 1 NC_007384.1 LexA regulated protein 674906 ybfE 3669692 ybfE Shigella sonnei Ss046 LexA regulated protein YP_309632.1 674544 R 300269 CDS YP_309633.1 74311214 3669693 complement(674977..675741) 1 NC_007384.1 Code: R; COG: COG0596; hypothetical protein 675741 ybfF 3669693 ybfF Shigella sonnei Ss046 hypothetical protein YP_309633.1 674977 R 300269 CDS YP_309634.1 74311215 3669694 675926..676471 1 NC_007384.1 negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 676471 seqA 3669694 seqA Shigella sonnei Ss046 replication initiation regulator SeqA YP_309634.1 675926 D 300269 CDS YP_309635.1 74311216 3669695 676497..678137 1 NC_007384.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 678137 pgm 3669695 pgm Shigella sonnei Ss046 phosphoglucomutase YP_309635.1 676497 D 300269 CDS YP_309636.1 74311217 3669696 complement(678193..679512) 1 NC_007384.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter 679512 potE 3669696 potE Shigella sonnei Ss046 putrescine transporter YP_309636.1 678193 R 300269 CDS YP_309637.1 74311218 3669697 complement(679509..681707) 1 NC_007384.1 Code: E; COG: COG1982; ornithine decarboxylase 681707 speF 3669697 speF Shigella sonnei Ss046 ornithine decarboxylase YP_309637.1 679509 R 300269 CDS YP_309638.1 74311219 3669698 complement(682397..683074) 1 NC_007384.1 transcriptional effector; response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; DNA-binding transcriptional activator KdpE 683074 kdpE 3669698 kdpE Shigella sonnei Ss046 DNA-binding transcriptional activator KdpE YP_309638.1 682397 R 300269 CDS YP_309639.1 74311220 3669699 complement(683071..685755) 1 NC_007384.1 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; sensor protein KdpD 685755 kdpD 3669699 kdpD Shigella sonnei Ss046 sensor protein KdpD YP_309639.1 683071 R 300269 CDS YP_309640.1 74311221 3669700 complement(685748..686320) 1 NC_007384.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 686320 kdpC 3669700 kdpC Shigella sonnei Ss046 potassium-transporting ATPase subunit C YP_309640.1 685748 R 300269 CDS YP_309641.1 74311222 3669643 complement(686329..688377) 1 NC_007384.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 688377 kdpB 3669643 kdpB Shigella sonnei Ss046 potassium-transporting ATPase subunit B YP_309641.1 686329 R 300269 CDS YP_309642.1 74311223 3669644 complement(688400..690073) 1 NC_007384.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 690073 kdpA 3669644 kdpA Shigella sonnei Ss046 potassium-transporting ATPase subunit A YP_309642.1 688400 R 300269 CDS YP_309643.1 74311224 3669645 complement(690073..690162) 1 NC_007384.1 one of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit F 690162 kdpF 3669645 kdpF Shigella sonnei Ss046 potassium-transporting ATPase subunit F YP_309643.1 690073 R 300269 CDS YP_309644.1 74311225 3669646 690475..690681 1 NC_007384.1 hypothetical protein 690681 ybfA 3669646 ybfA Shigella sonnei Ss046 hypothetical protein YP_309644.1 690475 D 300269 CDS YP_309645.1 74311226 3669647 690923..691681 1 NC_007384.1 hypothetical protein 691681 3669647 SSON_0652 Shigella sonnei Ss046 hypothetical protein YP_309645.1 690923 D 300269 CDS YP_309646.1 74311227 3669648 691896..693431 1 NC_007384.1 Code: L; COG: COG4584; transposase 693431 3669648 SSON_0653 Shigella sonnei Ss046 transposase YP_309646.1 691896 D 300269 CDS YP_309647.1 74311228 3669649 693448..694203 1 NC_007384.1 Code: L; COG: COG1484; transposase subunit 694203 3669649 SSON_0654 Shigella sonnei Ss046 transposase subunit YP_309647.1 693448 D 300269 CDS YP_309648.1 74311229 3669650 694244..697630 1 NC_007384.1 Code: M; COG: COG3209; rhsA protein in rhs element 697630 rhsA 3669650 rhsA Shigella sonnei Ss046 rhsA protein in rhs element YP_309648.1 694244 D 300269 CDS YP_309649.1 74311230 3669651 697875..698378 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 698378 3669651 SSON_0656 Shigella sonnei Ss046 IS1 ORF YP_309649.1 697875 D 300269 CDS YP_309650.1 74311231 3669652 complement(698504..699922) 1 NC_007384.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 699922 phrB 3669652 phrB Shigella sonnei Ss046 deoxyribodipyrimidine photolyase YP_309650.1 698504 R 300269 CDS YP_309651.1 74311232 3669653 complement(699919..700428) 1 NC_007384.1 Code: S; COG: COG3272; hypothetical protein 700428 ybgA 3669653 ybgA Shigella sonnei Ss046 hypothetical protein YP_309651.1 699919 R 300269 CDS YP_309652.1 74311233 3669654 complement(700957..701460) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 701460 3669654 SSON_0659 Shigella sonnei Ss046 IS1 ORF YP_309652.1 700957 R 300269 CDS YP_309653.1 74311234 3669655 complement(701759..703240) 1 NC_007384.1 Code: E; COG: COG3104; transporter 703240 ybgH 3669655 ybgH Shigella sonnei Ss046 transporter YP_309653.1 701759 R 300269 CDS YP_309654.1 74311235 3669656 703511..704254 1 NC_007384.1 Code: S; COG: COG0327; hydrolase-oxidase 704254 ybgI 3669656 ybgI Shigella sonnei Ss046 hydrolase-oxidase YP_309654.1 703511 D 300269 CDS YP_309655.1 74311236 3669657 704277..704933 1 NC_007384.1 Code: E; COG: COG2049; carboxylase 704933 ybgJ 3669657 ybgJ Shigella sonnei Ss046 carboxylase YP_309655.1 704277 D 300269 CDS YP_309656.1 74311237 3669658 704927..705859 1 NC_007384.1 Code: E; COG: COG1984; carboxylase 705859 ybgK 3669658 ybgK Shigella sonnei Ss046 carboxylase YP_309656.1 704927 D 300269 CDS YP_309657.1 74311238 3669659 705849..706583 1 NC_007384.1 Code: R; COG: COG1540; LamB/YcsF family protein 706583 ybgL 3669659 ybgL Shigella sonnei Ss046 LamB/YcsF family protein YP_309657.1 705849 D 300269 CDS YP_309658.1 74311239 3669660 706619..707410 1 NC_007384.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 707410 nei 3669660 nei Shigella sonnei Ss046 endonuclease VIII YP_309658.1 706619 D 300269 CDS YP_309659.1 74311240 3669661 complement(707407..708498) 1 NC_007384.1 Code: R; COG: COG3180; transporter 708498 abrB 3669661 abrB Shigella sonnei Ss046 transporter YP_309659.1 707407 R 300269 CDS YP_309660.1 74311241 3669554 complement(708605..709696) 1 NC_007384.1 hypothetical protein 709696 ybgO 3669554 ybgO Shigella sonnei Ss046 hypothetical protein YP_309660.1 708605 R 300269 CDS YP_309661.1 74311242 3669555 complement(709663..710394) 1 NC_007384.1 Code: NU; COG: COG3121; chaperone 710394 ybgP 3669555 ybgP Shigella sonnei Ss046 chaperone YP_309661.1 709663 R 300269 CDS YP_309662.1 74311243 3669557 complement(712918..713484) 1 NC_007384.1 Code: NU; COG: COG3539; fimbrial-like protein 713484 ybgD 3669557 ybgD Shigella sonnei Ss046 fimbrial-like protein YP_309662.1 712918 R 300269 CDS YP_309663.1 74311244 3669558 complement(713874..715157) 1 NC_007384.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 715157 gltA 3669558 gltA Shigella sonnei Ss046 type II citrate synthase YP_309663.1 713874 R 300269 CDS YP_309664.1 74311245 3669559 715866..716255 1 NC_007384.1 Code: C; COG: COG2009; succinate dehydrogenase cytochrome b556 large membrane subunit 716255 sdhC 3669559 sdhC Shigella sonnei Ss046 succinate dehydrogenase cytochrome b556 large membrane subunit YP_309664.1 715866 D 300269 CDS YP_309665.1 74311246 3669560 716249..716596 1 NC_007384.1 Code: C; COG: COG2142; succinate dehydrogenase cytochrome b556 small membrane subunit 716596 sdhD 3669560 sdhD Shigella sonnei Ss046 succinate dehydrogenase cytochrome b556 small membrane subunit YP_309665.1 716249 D 300269 CDS YP_309666.1 74311247 3669561 716596..718362 1 NC_007384.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 718362 sdhA 3669561 sdhA Shigella sonnei Ss046 succinate dehydrogenase flavoprotein subunit YP_309666.1 716596 D 300269 CDS YP_309667.1 74311248 3669562 718378..719094 1 NC_007384.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 719094 sdhB 3669562 sdhB Shigella sonnei Ss046 succinate dehydrogenase iron-sulfur subunit YP_309667.1 718378 D 300269 CDS YP_309668.1 74311249 3669563 719153..719413 1 NC_007384.1 hypothetical protein 719413 3669563 SSON_0676 Shigella sonnei Ss046 hypothetical protein YP_309668.1 719153 D 300269 CDS YP_309669.1 74311250 3669564 719395..722196 1 NC_007384.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 722196 sucA 3669564 sucA Shigella sonnei Ss046 2-oxoglutarate dehydrogenase E1 YP_309669.1 719395 D 300269 CDS YP_309670.1 74311251 3669565 722211..723428 1 NC_007384.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 723428 sucB 3669565 sucB Shigella sonnei Ss046 dihydrolipoamide succinyltransferase YP_309670.1 722211 D 300269 CDS YP_309671.1 74311252 3669566 723522..724688 1 NC_007384.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 724688 sucC 3669566 sucC Shigella sonnei Ss046 succinyl-CoA synthetase subunit beta YP_309671.1 723522 D 300269 CDS YP_309672.1 74311253 3669567 724688..725557 1 NC_007384.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 725557 sucD 3669567 sucD Shigella sonnei Ss046 succinyl-CoA synthetase subunit alpha YP_309672.1 724688 D 300269 CDS YP_309673.1 74311254 3669568 complement(725661..726383) 1 NC_007384.1 regulates the succiny-lCoA synthetase operon; DNA-binding transcriptional repressor MngR 726383 farR 3669568 farR Shigella sonnei Ss046 DNA-binding transcriptional repressor MngR YP_309673.1 725661 R 300269 CDS YP_309674.1 74311255 3669569 726492..728468 1 NC_007384.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC 728468 hrsA 3669569 hrsA Shigella sonnei Ss046 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC YP_309674.1 726492 D 300269 CDS YP_309675.1 74311256 3669571 731067..731294 1 NC_007384.1 hypothetical protein 731294 3669571 SSON_0684 Shigella sonnei Ss046 hypothetical protein YP_309675.1 731067 D 300269 CDS YP_309676.1 74311257 3669572 731887..733458 1 NC_007384.1 Code: C; COG: COG1271; cytochrome d terminal oxidase polypeptide subunit I 733458 cydA 3669572 cydA Shigella sonnei Ss046 cytochrome d terminal oxidase polypeptide subunit I YP_309676.1 731887 D 300269 CDS YP_309677.1 74311258 3669573 733474..734613 1 NC_007384.1 Code: C; COG: COG1294; cytochrome d terminal oxidase polypeptide subunit II 734613 cydB 3669573 cydB Shigella sonnei Ss046 cytochrome d terminal oxidase polypeptide subunit II YP_309677.1 733474 D 300269 CDS YP_309678.1 74311259 3669574 734741..735034 1 NC_007384.1 Code: S; COG: COG3790; hypothetical protein 735034 ybgE 3669574 ybgE Shigella sonnei Ss046 hypothetical protein YP_309678.1 734741 D 300269 CDS YP_309679.1 74311260 3669575 735184..735588 1 NC_007384.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase 735588 ybgC 3669575 ybgC Shigella sonnei Ss046 acyl-CoA thioester hydrolase YP_309679.1 735184 D 300269 CDS YP_309680.1 74311261 3669576 735585..736277 1 NC_007384.1 maintains integrity of cell envelope; tolerance to group A colicins; membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 736277 tolQ 3669576 tolQ Shigella sonnei Ss046 colicin uptake protein TolQ YP_309680.1 735585 D 300269 CDS YP_309681.1 74311262 3669577 736281..736709 1 NC_007384.1 involved in the tonB-independent uptake of group A colicins; membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 736709 tolR 3669577 tolR Shigella sonnei Ss046 colicin uptake protein TolR YP_309681.1 736281 D 300269 CDS YP_309682.1 74311263 3669578 736774..738006 1 NC_007384.1 required for outer membrane integrity; inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 738006 tolA 3669578 tolA Shigella sonnei Ss046 cell envelope integrity inner membrane protein TolA YP_309682.1 736774 D 300269 CDS YP_309683.1 74311264 3669579 738139..739431 1 NC_007384.1 involved in the tonB-independent uptake of group A colicins; forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 739431 tolB 3669579 tolB Shigella sonnei Ss046 translocation protein TolB YP_309683.1 738139 D 300269 CDS YP_309684.1 74311265 3669580 739466..739987 1 NC_007384.1 Code: M; COG: COG2885; peptidoglycan-associated outer membrane lipoprotein 739987 pal 3669580 pal Shigella sonnei Ss046 peptidoglycan-associated outer membrane lipoprotein YP_309684.1 739466 D 300269 CDS YP_309685.1 74311266 3669581 739997..740788 1 NC_007384.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 740788 ybgF 3669581 ybgF Shigella sonnei Ss046 tol-pal system protein YbgF YP_309685.1 739997 D 300269 CDS YP_309686.1 74311267 3669535 742950..744122 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 744122 3669535 SSON_0701 Shigella sonnei Ss046 IS21 ORF1 YP_309686.1 742950 D 300269 CDS YP_309687.1 74311268 3669536 744122..744919 1 NC_007384.1 Code: L; COG: COG1484; IS21 ORF2 744919 3669536 SSON_0702 Shigella sonnei Ss046 IS21 ORF2 YP_309687.1 744122 D 300269 CDS YP_309688.1 74311269 3669537 745182..745901 1 NC_007384.1 Code: H; COG: COG3201; required for NMN transport 745901 pnuC 3669537 pnuC Shigella sonnei Ss046 required for NMN transport YP_309688.1 745182 D 300269 CDS YP_309689.1 74311270 3669538 complement(745898..746839) 1 NC_007384.1 involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB 746839 ybgR 3669538 ybgR Shigella sonnei Ss046 zinc transporter ZitB YP_309689.1 745898 R 300269 CDS YP_309690.1 74311271 3669539 complement(746953..747333) 1 NC_007384.1 homeobox protein 747333 3669539 SSON_0705 Shigella sonnei Ss046 homeobox protein YP_309690.1 746953 R 300269 CDS YP_309691.1 74311272 3669540 747649..748701 1 NC_007384.1 DAHP synthetase; phenylalanine repressible; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 748701 aroG 3669540 aroG Shigella sonnei Ss046 phospho-2-dehydro-3-deoxyheptonate aldolase YP_309691.1 747649 D 300269 CDS YP_309692.1 74311273 3669541 complement(748860..749612) 1 NC_007384.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 749612 gpmA 3669541 gpmA Shigella sonnei Ss046 phosphoglyceromutase YP_309692.1 748860 R 300269 CDS YP_309693.1 74311274 3669542 complement(749815..750855) 1 NC_007384.1 mutarotase; catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase 750855 galM 3669542 galM Shigella sonnei Ss046 aldose 1-epimerase YP_309693.1 749815 R 300269 CDS YP_309694.1 74311275 3669543 complement(750849..751997) 1 NC_007384.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 751997 galK 3669543 galK Shigella sonnei Ss046 galactokinase YP_309694.1 750849 R 300269 CDS YP_309695.1 74311276 3669544 complement(752001..753047) 1 NC_007384.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 753047 galT 3669544 galT Shigella sonnei Ss046 galactose-1-phosphate uridylyltransferase YP_309695.1 752001 R 300269 CDS YP_309696.1 74311277 3669545 complement(753057..754073) 1 NC_007384.1 Code: M; COG: COG1087; UDP-galactose-4-epimerase 754073 galE 3669545 galE Shigella sonnei Ss046 UDP-galactose-4-epimerase YP_309696.1 753057 R 300269 CDS YP_309697.1 74311278 3669546 complement(754334..755806) 1 NC_007384.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum; molybdenum transport ATP-binding protein ModF 755806 modF 3669546 modF Shigella sonnei Ss046 molybdenum transport ATP-binding protein ModF YP_309697.1 754334 R 300269 CDS YP_309698.1 74311279 3669547 complement(755874..756662) 1 NC_007384.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE 756662 modE 3669547 modE Shigella sonnei Ss046 DNA-binding transcriptional regulator ModE YP_309698.1 755874 R 300269 CDS YP_309699.1 74311280 3669548 756791..756940 1 NC_007384.1 hypothetical protein 756940 3669548 SSON_0714 Shigella sonnei Ss046 hypothetical protein YP_309699.1 756791 D 300269 CDS YP_309700.1 74311281 3669549 757106..757879 1 NC_007384.1 permease; with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein 757879 modA 3669549 modA Shigella sonnei Ss046 molybdate transporter periplasmic protein YP_309700.1 757106 D 300269 CDS YP_309701.1 74311282 3669550 757879..758568 1 NC_007384.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 758568 modB 3669550 modB Shigella sonnei Ss046 molybdate ABC transporter permease YP_309701.1 757879 D 300269 CDS YP_309702.1 74311283 3669551 758571..759629 1 NC_007384.1 Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 759629 modC 3669551 modC Shigella sonnei Ss046 molybdate transporter ATP-binding protein YP_309702.1 758571 D 300269 CDS YP_309703.1 74311284 3669552 760456..760758 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 760758 3669552 SSON_0718 Shigella sonnei Ss046 IS600 ORF1 YP_309703.1 760456 D 300269 CDS YP_309704.1 74311285 3669553 760899..761612 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 761612 3669553 SSON_0719 Shigella sonnei Ss046 IS600 ORF2 YP_309704.1 760899 D 300269 CDS YP_309705.1 74311286 3669720 complement(762001..762288) 1 NC_007384.1 hypothetical protein 762288 rem 3669720 rem Shigella sonnei Ss046 hypothetical protein YP_309705.1 762001 R 300269 CDS YP_309706.1 74311287 3669721 complement(762921..763607) 1 NC_007384.1 Code: S; COG: COG1636; hypothetical protein 763607 3669721 SSON_0721 Shigella sonnei Ss046 hypothetical protein YP_309706.1 762921 R 300269 CDS YP_309707.1 74311288 3669722 complement(763755..764111) 1 NC_007384.1 bacteriophage protein 764111 3669722 SSON_0722 Shigella sonnei Ss046 bacteriophage protein YP_309707.1 763755 R 300269 CDS YP_309708.1 74311289 3669723 complement(764606..765352) 1 NC_007384.1 Code: L; COG: COG1484; replication protein 765352 3669723 SSON_0723 Shigella sonnei Ss046 replication protein YP_309708.1 764606 R 300269 CDS YP_309709.1 74311290 3669725 766100..766402 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 766402 3669725 SSON_0725 Shigella sonnei Ss046 IS600 ORF1 YP_309709.1 766100 D 300269 CDS YP_309710.1 74311291 3669726 766543..767256 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 767256 3669726 SSON_0726 Shigella sonnei Ss046 IS600 ORF2 YP_309710.1 766543 D 300269 CDS YP_309711.1 74311292 3669727 complement(767484..767789) 1 NC_007384.1 bacteriophage protein 767789 3669727 SSON_0727 Shigella sonnei Ss046 bacteriophage protein YP_309711.1 767484 R 300269 CDS YP_309712.1 74311293 3669728 768804..768959 1 NC_007384.1 hypothetical protein 768959 3669728 SSON_0728 Shigella sonnei Ss046 hypothetical protein YP_309712.1 768804 D 300269 CDS YP_309713.1 74311294 3669729 769036..769338 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 769338 3669729 SSON_0729 Shigella sonnei Ss046 IS600 ORF1 YP_309713.1 769036 D 300269 CDS YP_309714.1 74311295 3669730 complement(769686..770525) 1 NC_007384.1 Code: L; COG: COG2801; IS911 ORF2 770525 3669730 SSON_0730 Shigella sonnei Ss046 IS911 ORF2 YP_309714.1 769686 R 300269 CDS YP_309715.1 74311296 3669731 complement(771491..772687) 1 NC_007384.1 Code: L; COG: COG3547; ISSfl2 ORF 772687 3669731 SSON_0731 Shigella sonnei Ss046 ISSfl2 ORF YP_309715.1 771491 R 300269 CDS YP_309716.2 161986566 3669732 complement(773134..774039) 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 774039 3669732 SSON_0732 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_309716.2 773134 R 300269 CDS YP_309717.1 74311298 3669733 774476..774973 1 NC_007384.1 similar to bacteriophage lambda lysozyme; Code: R; COG: COG3772; lysozyme-like protein 774973 3669733 SSON_0733 Shigella sonnei Ss046 lysozyme-like protein YP_309717.1 774476 D 300269 CDS YP_309718.1 74311299 3669734 774970..775440 1 NC_007384.1 endopeptidase 775440 3669734 SSON_0734 Shigella sonnei Ss046 endopeptidase YP_309718.1 774970 D 300269 CDS YP_309719.1 74311300 3669735 776236..777000 1 NC_007384.1 bacteriophage protein 777000 3669735 SSON_0735 Shigella sonnei Ss046 bacteriophage protein YP_309719.1 776236 D 300269 CDS YP_309720.1 74311301 3669736 776933..778354 1 NC_007384.1 Code: R; COG: COG1783; bacteriophage protein 778354 3669736 SSON_0736 Shigella sonnei Ss046 bacteriophage protein YP_309720.1 776933 D 300269 CDS YP_309721.1 74311302 3669737 778738..779820 1 NC_007384.1 bacteriophage protein 779820 3669737 SSON_0737 Shigella sonnei Ss046 bacteriophage protein YP_309721.1 778738 D 300269 CDS YP_309722.1 74311303 3669738 780458..781678 1 NC_007384.1 bacteriophage protein 781678 3669738 SSON_0738 Shigella sonnei Ss046 bacteriophage protein YP_309722.1 780458 D 300269 CDS YP_309723.1 74311304 3669739 781682..782188 1 NC_007384.1 bacteriophage protein 782188 3669739 SSON_0739 Shigella sonnei Ss046 bacteriophage protein YP_309723.1 781682 D 300269 CDS YP_309724.1 74311305 3669791 782453..782956 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 782956 3669791 SSON_0740 Shigella sonnei Ss046 IS1 ORF YP_309724.1 782453 D 300269 CDS YP_309725.1 74311306 3669792 783379..784374 1 NC_007384.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 784374 ybhE 3669792 ybhE Shigella sonnei Ss046 6-phosphogluconolactonase YP_309725.1 783379 D 300269 CDS YP_309726.1 74311307 3669793 complement(784415..785431) 1 NC_007384.1 Code: K; COG: COG0583; LysR family transcriptional regulator 785431 ybhD 3669793 ybhD Shigella sonnei Ss046 LysR family transcriptional regulator YP_309726.1 784415 R 300269 CDS YP_309727.1 74311308 3669794 complement(785584..786087) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 786087 3669794 SSON_0743 Shigella sonnei Ss046 IS1 ORF YP_309727.1 785584 R 300269 CDS YP_309728.1 74311309 3669795 786323..788503 1 NC_007384.1 Code: C; COG: COG1048; hypothetical protein 788503 ybhJ 3669795 ybhJ Shigella sonnei Ss046 hypothetical protein YP_309728.1 786323 D 300269 CDS YP_309729.1 74311310 3669796 complement(788737..790020) 1 NC_007384.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family; pectinesterase 790020 ybhC 3669796 ybhC Shigella sonnei Ss046 pectinesterase YP_309729.1 788737 R 300269 CDS YP_309730.1 74311311 3669797 complement(790155..790967) 1 NC_007384.1 Code: L; COG: COG0582; integrase fragment 790967 intE 3669797 intE Shigella sonnei Ss046 integrase fragment YP_309730.1 790155 R 300269 CDS YP_309731.1 74311312 3669798 complement(790995..791708) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 791708 3669798 SSON_0747 Shigella sonnei Ss046 IS600 ORF2 YP_309731.1 790995 R 300269 CDS YP_309732.1 74311313 3669799 complement(791849..792151) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 792151 3669799 SSON_0748 Shigella sonnei Ss046 IS600 ORF1 YP_309732.1 791849 R 300269 CDS YP_309733.1 74311314 3669800 792167..793420 1 NC_007384.1 tail fiber protein 793420 3669800 SSON_0749 Shigella sonnei Ss046 tail fiber protein YP_309733.1 792167 D 300269 CDS YP_309734.1 74311315 3669801 793371..793994 1 NC_007384.1 prophage tail protein 793994 3669801 SSON_0750 Shigella sonnei Ss046 prophage tail protein YP_309734.1 793371 D 300269 CDS YP_309735.1 74311316 3669802 complement(794174..795937) 1 NC_007384.1 Code: S; COG: COG4886; invasion plasmid antigen 795937 ipaH_1 3669802 ipaH_1 Shigella sonnei Ss046 invasion plasmid antigen YP_309735.1 794174 R 300269 CDS YP_309736.1 74311317 3669803 complement(796519..796995) 1 NC_007384.1 YbhB; similar to rat and human kinase inhibitory proteins; kinase inhibitor protein 796995 ybhB 3669803 ybhB Shigella sonnei Ss046 kinase inhibitor protein YP_309736.1 796519 R 300269 CDS YP_309737.1 74311318 3669804 complement(797054..798343) 1 NC_007384.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 798343 bioA 3669804 bioA Shigella sonnei Ss046 adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_309737.1 797054 R 300269 CDS YP_309738.1 74311319 3669805 798430..799470 1 NC_007384.1 possible sulfur insertion; Code: H; COG: COG0502; biotin synthase 799470 bioB 3669805 bioB Shigella sonnei Ss046 biotin synthase YP_309738.1 798430 D 300269 CDS YP_309739.1 74311320 3669806 799467..800621 1 NC_007384.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 800621 bioF 3669806 bioF Shigella sonnei Ss046 8-amino-7-oxononanoate synthase YP_309739.1 799467 D 300269 CDS YP_309740.1 74311321 3669807 800608..801363 1 NC_007384.1 reaction prior to pimeloyl CoA; methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 801363 bioC 3669807 bioC Shigella sonnei Ss046 biotin biosynthesis protein BioC YP_309740.1 800608 D 300269 CDS YP_309741.1 74311322 3669808 801356..802033 1 NC_007384.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 802033 bioD 3669808 bioD Shigella sonnei Ss046 dithiobiotin synthetase YP_309741.1 801356 D 300269 CDS YP_309742.1 74311323 3669809 802612..804633 1 NC_007384.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 804633 uvrB 3669809 uvrB Shigella sonnei Ss046 excinuclease ABC subunit B YP_309742.1 802612 D 300269 CDS YP_309743.1 74311324 3669827 complement(804825..805733) 1 NC_007384.1 Code: S; COG: COG0391; structural protein 805733 ybhK 3669827 ybhK Shigella sonnei Ss046 structural protein YP_309743.1 804825 R 300269 CDS YP_309744.1 74311325 3669828 806130..807119 1 NC_007384.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 807119 moaA 3669828 moaA Shigella sonnei Ss046 molybdenum cofactor biosynthesis protein A YP_309744.1 806130 D 300269 CDS YP_309745.1 74311326 3669829 807141..807653 1 NC_007384.1 Code: H; COG: COG0521; molybdopterin biosynthesis, protein B 807653 moaB 3669829 moaB Shigella sonnei Ss046 molybdopterin biosynthesis, protein B YP_309745.1 807141 D 300269 CDS YP_309746.1 74311327 3669830 807656..808141 1 NC_007384.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 808141 moaC 3669830 moaC Shigella sonnei Ss046 molybdenum cofactor biosynthesis protein MoaC YP_309746.1 807656 D 300269 CDS YP_309747.1 74311328 3669831 808134..808379 1 NC_007384.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 808379 moaD 3669831 moaD Shigella sonnei Ss046 molybdopterin synthase small subunit YP_309747.1 808134 D 300269 CDS YP_309748.1 74311329 3669832 808381..808833 1 NC_007384.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin guanine dinucleotide biosynthesis protein MoaE 808833 moaE 3669832 moaE Shigella sonnei Ss046 molybdopterin guanine dinucleotide biosynthesis protein MoaE YP_309748.1 808381 D 300269 CDS YP_309749.1 74311330 3669833 808970..809674 1 NC_007384.1 Code: R; COG: COG0670; hypothetical protein 809674 ybhL 3669833 ybhL Shigella sonnei Ss046 hypothetical protein YP_309749.1 808970 D 300269 CDS YP_309750.1 74311331 3669834 809879..810592 1 NC_007384.1 Code: R; COG: COG0670; hypothetical protein 810592 ybhM 3669834 ybhM Shigella sonnei Ss046 hypothetical protein YP_309750.1 809879 D 300269 CDS YP_309751.1 74311332 3669836 complement(811368..812609) 1 NC_007384.1 Code: I; COG: COG1502; cardiolipin synthase 2 812609 ybhO 3669836 ybhO Shigella sonnei Ss046 cardiolipin synthase 2 YP_309751.1 811368 R 300269 CDS YP_309752.1 74311333 3669837 complement(812606..813367) 1 NC_007384.1 Code: R; COG: COG3568; hypothetical protein 813367 ybhP 3669837 ybhP Shigella sonnei Ss046 hypothetical protein YP_309752.1 812606 R 300269 CDS YP_309753.1 74311334 3669838 813500..813910 1 NC_007384.1 hypothetical protein 813910 ybhQ 3669838 ybhQ Shigella sonnei Ss046 hypothetical protein YP_309753.1 813500 D 300269 CDS YP_309754.1 74311335 3669839 complement(813872..814978) 1 NC_007384.1 Code: V; COG: COG0842; hypothetical protein 814978 ybhR 3669839 ybhR Shigella sonnei Ss046 hypothetical protein YP_309754.1 813872 R 300269 CDS YP_309755.1 74311336 3669840 complement(814989..816122) 1 NC_007384.1 Code: V; COG: COG0842; hypothetical protein 816122 ybhS 3669840 ybhS Shigella sonnei Ss046 hypothetical protein YP_309755.1 814989 R 300269 CDS YP_309756.1 74311337 3669841 complement(816115..817851) 1 NC_007384.1 Code: V; COG: COG1131; ABC transporter ATP-binding protein 817851 ybhF 3669841 ybhF Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_309756.1 816115 R 300269 CDS YP_309757.1 74311338 3669842 complement(817844..818842) 1 NC_007384.1 Code: M; COG: COG0845; hypothetical protein 818842 3669842 SSON_0774 Shigella sonnei Ss046 hypothetical protein YP_309757.1 817844 R 300269 CDS YP_309758.1 74311339 3669843 complement(818842..819525) 1 NC_007384.1 Code: K; COG: COG1309; DNA-binding transcriptional regulator 819525 ybiH 3669843 ybiH Shigella sonnei Ss046 DNA-binding transcriptional regulator YP_309758.1 818842 R 300269 CDS YP_309759.1 74311340 3669844 819742..821106 1 NC_007384.1 this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 821106 rhlE 3669844 rhlE Shigella sonnei Ss046 ATP-dependent RNA helicase RhlE YP_309759.1 819742 D 300269 CDS YP_309760.1 74311341 3669845 complement(821338..821820) 1 NC_007384.1 Code: S; COG: COG3236; hypothetical protein 821820 ybiA 3669845 ybiA Shigella sonnei Ss046 hypothetical protein YP_309760.1 821338 R 300269 CDS YP_309761.1 74311342 3669846 821940..824090 1 NC_007384.1 helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 824090 dinG 3669846 dinG Shigella sonnei Ss046 ATP-dependent DNA helicase DinG YP_309761.1 821940 D 300269 CDS YP_309762.1 74311343 3669847 824118..825080 1 NC_007384.1 Code: E; COG: COG0547; glycosyl transferase family protein 825080 ybiB 3669847 ybiB Shigella sonnei Ss046 glycosyl transferase family protein YP_309762.1 824118 D 300269 CDS YP_309763.1 74311344 3669848 825221..826306 1 NC_007384.1 Code: C; COG: COG2055; hypothetical protein 826306 ybiC 3669848 ybiC Shigella sonnei Ss046 hypothetical protein YP_309763.1 825221 D 300269 CDS YP_309764.1 74311345 3669849 complement(826535..826795) 1 NC_007384.1 hypothetical protein 826795 ybiJ 3669849 ybiJ Shigella sonnei Ss046 hypothetical protein YP_309764.1 826535 R 300269 CDS YP_309765.1 74311346 3669850 complement(827060..827326) 1 NC_007384.1 Code: T; COG: COG1734; hypothetical protein 827326 ybiI 3669850 ybiI Shigella sonnei Ss046 hypothetical protein YP_309765.1 827060 R 300269 CDS YP_309766.2 161986565 3669851 complement(827400..828077) 1 NC_007384.1 Code: S; COG: COG3128; hydroxylase 828077 ybiX 3669851 ybiX Shigella sonnei Ss046 hydroxylase YP_309766.2 827400 R 300269 CDS YP_309767.1 74311348 3669852 complement(830122..831468) 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 831468 3669852 SSON_0784 Shigella sonnei Ss046 IS4 orf YP_309767.1 830122 R 300269 CDS YP_309768.1 74311349 3669854 complement(832104..832508) 1 NC_007384.1 hypothetical protein 832508 ybiM 3669854 ybiM Shigella sonnei Ss046 hypothetical protein YP_309768.1 832104 R 300269 CDS YP_309769.1 74311350 3669855 832559..833566 1 NC_007384.1 Code: R; COG: COG3129; SAM-dependent methyltransferase 833566 ybiN 3669855 ybiN Shigella sonnei Ss046 SAM-dependent methyltransferase YP_309769.1 832559 D 300269 CDS YP_309770.1 74311351 3669856 complement(833563..835788) 1 NC_007384.1 Code: M; COG: COG0668; hypothetical protein 835788 ybiO 3669856 ybiO Shigella sonnei Ss046 hypothetical protein YP_309770.1 833563 R 300269 CDS YP_309771.1 74311352 3669857 complement(835905..836627) 1 NC_007384.1 similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein 836627 glnQ 3669857 glnQ Shigella sonnei Ss046 glutamine ABC transporter ATP-binding protein YP_309771.1 835905 R 300269 CDS YP_309772.1 74311353 3669858 complement(836624..837283) 1 NC_007384.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease 837283 glnP 3669858 glnP Shigella sonnei Ss046 glutamine ABC transporter permease YP_309772.1 836624 R 300269 CDS YP_309773.1 74311354 3669859 complement(837422..838168) 1 NC_007384.1 permease; similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein 838168 glnH 3669859 glnH Shigella sonnei Ss046 glutamine ABC transporter periplasmic protein YP_309773.1 837422 R 300269 CDS YP_309774.1 74311355 3669860 complement(838572..839075) 1 NC_007384.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps 839075 dps 3669860 dps Shigella sonnei Ss046 DNA starvation/stationary phase protection protein Dps YP_309774.1 838572 R 300269 CDS YP_309775.1 74311356 3669861 complement(839374..840261) 1 NC_007384.1 Code: R; COG: COG5006; threonine and homoserine efflux system 840261 ybiF 3669861 ybiF Shigella sonnei Ss046 threonine and homoserine efflux system YP_309775.1 839374 R 300269 CDS YP_309776.1 74311357 3669862 840614..841129 1 NC_007384.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 841129 ompX 3669862 ompX Shigella sonnei Ss046 outer membrane protein X YP_309776.1 840614 D 300269 CDS YP_309777.1 74311358 3669863 complement(841178..842761) 1 NC_007384.1 Code: R; COG: COG2194; hypothetical protein 842761 ybiP 3669863 ybiP Shigella sonnei Ss046 hypothetical protein YP_309777.1 841178 R 300269 CDS YP_309778.1 74311359 3669864 843347..843814 1 NC_007384.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 843814 3669864 SSON_0796 Shigella sonnei Ss046 manganese transport regulator MntR YP_309778.1 843347 D 300269 CDS YP_309779.1 74311360 3669865 843811..844929 1 NC_007384.1 Code: P; COG: COG0471; hypothetical protein 844929 ybiR 3669865 ybiR Shigella sonnei Ss046 hypothetical protein YP_309779.1 843811 D 300269 CDS YP_309780.1 74311361 3669866 complement(844988..845908) 1 NC_007384.1 Code: S; COG: COG1376; hypothetical protein 845908 ybiS 3669866 ybiS Shigella sonnei Ss046 hypothetical protein YP_309780.1 844988 R 300269 CDS YP_309781.1 74311362 3669867 846127..847722 1 NC_007384.1 Code: R; COG: COG0488; ABC transporter ATP-binding protein 847722 ybiT 3669867 ybiT Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_309781.1 846127 D 300269 CDS YP_309782.1 74311363 3669868 complement(847902..850265) 1 NC_007384.1 Code: G; COG: COG1501; glucosidase 850265 3669868 SSON_0800 Shigella sonnei Ss046 glucosidase YP_309782.1 847902 R 300269 CDS YP_309783.1 74311364 3669869 complement(850280..851581) 1 NC_007384.1 Code: GEPR; COG: COG0477; hexuronate transporter 851581 3669869 SSON_0801 Shigella sonnei Ss046 hexuronate transporter YP_309783.1 850280 R 300269 CDS YP_309784.1 74311365 3669870 851876..852979 1 NC_007384.1 Code: K; COG: COG1609; transcriptional regulator 852979 3669870 SSON_0802 Shigella sonnei Ss046 transcriptional regulator YP_309784.1 851876 D 300269 CDS YP_309785.1 74311366 3669871 complement(852946..854211) 1 NC_007384.1 hypothetical protein 854211 ybiU 3669871 ybiU Shigella sonnei Ss046 hypothetical protein YP_309785.1 852946 R 300269 CDS YP_309786.1 74311367 3669872 complement(854363..855178) 1 NC_007384.1 Code: R; COG: COG0561; hypothetical protein 855178 3669872 SSON_0804 Shigella sonnei Ss046 hypothetical protein YP_309786.1 854363 R 300269 CDS YP_309787.1 74311368 3669873 complement(855324..857756) 1 NC_007384.1 Code: C; COG: COG1882; formate acetyltransferase 857756 ybiW 3669873 ybiW Shigella sonnei Ss046 formate acetyltransferase YP_309787.1 855324 R 300269 CDS YP_309788.1 74311369 3669874 complement(857762..858688) 1 NC_007384.1 Code: O; COG: COG1180; pyruvate formate-lyase 2 activating enzyme 858688 ybiY 3669874 ybiY Shigella sonnei Ss046 pyruvate formate-lyase 2 activating enzyme YP_309788.1 857762 R 300269 CDS YP_309789.2 161986564 3669875 858792..859454 1 NC_007384.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 859454 mipB 3669875 mipB Shigella sonnei Ss046 fructose-6-phosphate aldolase YP_309789.2 858792 D 300269 CDS YP_309790.1 74311371 3669876 complement(859633..860382) 1 NC_007384.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 860382 moeB 3669876 moeB Shigella sonnei Ss046 molybdopterin biosynthesis protein MoeB YP_309790.1 859633 R 300269 CDS YP_309791.1 74311372 3669877 complement(860382..861617) 1 NC_007384.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA 861617 moeA 3669877 moeA Shigella sonnei Ss046 molybdopterin biosynthesis protein MoeA YP_309791.1 860382 R 300269 CDS YP_309792.1 74311373 3669878 861821..862786 1 NC_007384.1 Code: E; COG: COG1446; L-asparaginase 862786 ybiK 3669878 ybiK Shigella sonnei Ss046 L-asparaginase YP_309792.1 861821 D 300269 CDS YP_309793.1 74311374 3669879 862806..864644 1 NC_007384.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 864644 3669879 SSON_0811 Shigella sonnei Ss046 glutathione transporter ATP-binding protein YP_309793.1 862806 D 300269 CDS YP_309794.1 74311375 3669880 864664..866202 1 NC_007384.1 Code: E; COG: COG0747; transporter 866202 3669880 SSON_0812 Shigella sonnei Ss046 transporter YP_309794.1 864664 D 300269 CDS YP_309795.1 74311376 3669881 866220..867140 1 NC_007384.1 Code: EP; COG: COG0601; transport system permease 867140 3669881 SSON_0813 Shigella sonnei Ss046 transport system permease YP_309795.1 866220 D 300269 CDS YP_309796.1 74311377 3669882 867143..868054 1 NC_007384.1 Code: EP; COG: COG1173; transport system permease 868054 3669882 SSON_0814 Shigella sonnei Ss046 transport system permease YP_309796.1 867143 D 300269 CDS YP_309797.1 74311378 3669884 869051..869554 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 869554 3669884 SSON_0816 Shigella sonnei Ss046 IS1 ORF YP_309797.1 869051 D 300269 CDS YP_309798.1 74311379 3669701 complement(872248..873573) 1 NC_007384.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; 30S ribosomal protein S12 methylthiotransferase 873573 rimO 3669701 rimO Shigella sonnei Ss046 30S ribosomal protein S12 methylthiotransferase YP_309798.1 872248 R 300269 CDS YP_309799.1 74311380 3669702 873786..874169 1 NC_007384.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 874169 bssR 3669702 bssR Shigella sonnei Ss046 biofilm formation regulatory protein BssR YP_309799.1 873786 D 300269 CDS YP_309800.1 74311381 3669703 874280..875395 1 NC_007384.1 Code: G; COG: COG2133; dehydrogenase 875395 yliI 3669703 yliI Shigella sonnei Ss046 dehydrogenase YP_309800.1 874280 D 300269 CDS YP_309801.1 74311382 3669704 complement(875392..875970) 1 NC_007384.1 Code: O; COG: COG0625; transferase 875970 yliJ 3669704 yliJ Shigella sonnei Ss046 transferase YP_309801.1 875392 R 300269 CDS YP_309802.1 74311383 3669706 876440..876742 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 876742 3669706 SSON_0823 Shigella sonnei Ss046 IS600 ORF1 YP_309802.1 876440 D 300269 CDS YP_309803.1 74311384 3669707 876883..877596 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 877596 3669707 SSON_0824 Shigella sonnei Ss046 IS600 ORF2 YP_309803.1 876883 D 300269 CDS YP_309804.1 74311385 3669708 complement(878781..879539) 1 NC_007384.1 Code: KG; COG: COG1349; DNA-binding transcriptional repressor DeoR 879539 deoR 3669708 deoR Shigella sonnei Ss046 DNA-binding transcriptional repressor DeoR YP_309804.1 878781 R 300269 CDS YP_309805.1 74311386 3669709 complement(879597..880193) 1 NC_007384.1 Code: I; COG: COG0671; undecaprenyl pyrophosphate phosphatase 880193 ybjG 3669709 ybjG Shigella sonnei Ss046 undecaprenyl pyrophosphate phosphatase YP_309805.1 879597 R 300269 CDS YP_309806.1 74311387 3669711 complement(881746..882030) 1 NC_007384.1 hypothetical protein 882030 ybjH 3669711 ybjH Shigella sonnei Ss046 hypothetical protein YP_309806.1 881746 R 300269 CDS YP_309807.1 74311388 3669712 complement(882116..882904) 1 NC_007384.1 Code: R; COG: COG0561; hypothetical protein 882904 3669712 SSON_0829 Shigella sonnei Ss046 hypothetical protein YP_309807.1 882116 R 300269 CDS YP_309808.1 74311389 3669713 complement(882931..884139) 1 NC_007384.1 Code: GEPR; COG: COG0477; DeoR-type transcriptional regulator 884139 3669713 SSON_0830 Shigella sonnei Ss046 DeoR-type transcriptional regulator YP_309808.1 882931 R 300269 CDS YP_309809.1 74311390 3669714 884223..884759 1 NC_007384.1 Code: S; COG: COG3226; DeoR-type transcriptional regulator 884759 3669714 SSON_0831 Shigella sonnei Ss046 DeoR-type transcriptional regulator YP_309809.1 884223 D 300269 CDS YP_309810.1 74311391 3669715 complement(884934..886619) 1 NC_007384.1 Code: R; COG: COG2985; hypothetical protein 886619 3669715 SSON_0832 Shigella sonnei Ss046 hypothetical protein YP_309810.1 884934 R 300269 CDS YP_309811.1 74311392 3669716 886889..887266 1 NC_007384.1 hypothetical protein 887266 ybjM 3669716 ybjM Shigella sonnei Ss046 hypothetical protein YP_309811.1 886889 D 300269 CDS YP_309812.1 74311393 3669717 complement(887296..887553) 1 NC_007384.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 887553 grxA 3669717 grxA Shigella sonnei Ss046 glutaredoxin YP_309812.1 887296 R 300269 CDS YP_309813.1 74311394 3669718 887713..888000 1 NC_007384.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 888000 ybjC 3669718 ybjC Shigella sonnei Ss046 hypothetical protein YP_309813.1 887713 D 300269 CDS YP_309814.1 74311395 3669719 887984..888706 1 NC_007384.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 888706 mdaA 3669719 mdaA Shigella sonnei Ss046 nitroreductase A YP_309814.1 887984 D 300269 CDS YP_309815.1 74311396 3666327 888767..889669 1 NC_007384.1 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 889669 rimK 3666327 rimK Shigella sonnei Ss046 ribosomal protein S6 modification protein YP_309815.1 888767 D 300269 CDS YP_309816.1 74311397 3666328 889757..890233 1 NC_007384.1 sensory transduction regulator 890233 ybjN 3666328 ybjN Shigella sonnei Ss046 sensory transduction regulator YP_309816.1 889757 D 300269 CDS YP_309817.1 74311398 3666329 890584..891696 1 NC_007384.1 permease protein; Code: E; COG: COG0687; putrescine ABC transporter periplasmic-binding protein 891696 potF 3666329 potF Shigella sonnei Ss046 putrescine ABC transporter periplasmic-binding protein YP_309817.1 890584 D 300269 CDS YP_309818.2 161986563 3666330 891791..892924 1 NC_007384.1 part of the PotFGHI ATP-dependent putrescine transporter; putrescine ABC transporter ATP-binding protein 892924 potG 3666330 potG Shigella sonnei Ss046 putrescine ABC transporter ATP-binding protein YP_309818.2 891791 D 300269 CDS YP_309819.1 74311400 3666331 892934..893887 1 NC_007384.1 permease; Code: E; COG: COG1176; putrescine ABC transporter membrane protein 893887 potH 3666331 potH Shigella sonnei Ss046 putrescine ABC transporter membrane protein YP_309819.1 892934 D 300269 CDS YP_309820.1 74311401 3666332 893884..894729 1 NC_007384.1 permease; Code: E; COG: COG1177; putrescine ABC transporter membrane protein 894729 potI 3666332 potI Shigella sonnei Ss046 putrescine ABC transporter membrane protein YP_309820.1 893884 D 300269 CDS YP_309821.1 74311402 3666333 894789..895277 1 NC_007384.1 hypothetical protein 895277 ybjO 3666333 ybjO Shigella sonnei Ss046 hypothetical protein YP_309821.1 894789 D 300269 CDS YP_309822.1 74311403 3666334 895318..896445 1 NC_007384.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 896445 rumB 3666334 rumB Shigella sonnei Ss046 23S rRNA methyluridine methyltransferase YP_309822.1 895318 D 300269 CDS YP_309823.1 74311404 3666335 complement(896620..897351) 1 NC_007384.1 Code: ET; COG: COG0834; arginine ABC transporter substrate-binding protein 897351 artJ 3666335 artJ Shigella sonnei Ss046 arginine ABC transporter substrate-binding protein YP_309823.1 896620 R 300269 CDS YP_309824.1 74311405 3666336 complement(897644..898312) 1 NC_007384.1 with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM 898312 artM 3666336 artM Shigella sonnei Ss046 arginine transporter permease subunit ArtM YP_309824.1 897644 R 300269 CDS YP_309825.1 74311406 3666337 complement(898312..899028) 1 NC_007384.1 with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ 899028 artQ 3666337 artQ Shigella sonnei Ss046 arginine transporter permease subunit ArtQ YP_309825.1 898312 R 300269 CDS YP_309826.1 74311407 3666338 complement(899035..899766) 1 NC_007384.1 Code: ET; COG: COG0834; arginine ABC transporter substrate-binding protein 899766 artI 3666338 artI Shigella sonnei Ss046 arginine ABC transporter substrate-binding protein YP_309826.1 899035 R 300269 CDS YP_309827.1 74311408 3666339 complement(899784..900512) 1 NC_007384.1 With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit 900512 artP 3666339 artP Shigella sonnei Ss046 arginine transporter ATP-binding subunit YP_309827.1 899784 R 300269 CDS YP_309828.1 74311409 3666340 complement(900730..901245) 1 NC_007384.1 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS; lipoprotein 901245 ybjP 3666340 ybjP Shigella sonnei Ss046 lipoprotein YP_309828.1 900730 R 300269 CDS YP_309829.1 74311410 3666341 901894..903663 1 NC_007384.1 hypothetical protein 903663 3666341 SSON_0851 Shigella sonnei Ss046 hypothetical protein YP_309829.1 901894 D 300269 CDS YP_309830.1 74311411 3666342 903874..904197 1 NC_007384.1 Code: S; COG: COG0393; hypothetical protein 904197 3666342 SSON_0852 Shigella sonnei Ss046 hypothetical protein YP_309830.1 903874 D 300269 CDS YP_309831.1 74311412 3666343 904194..905024 1 NC_007384.1 Code: V; COG: COG3023; regulator 905024 3666343 SSON_0853 Shigella sonnei Ss046 regulator YP_309831.1 904194 D 300269 CDS YP_309832.1 74311413 3666344 complement(905021..906070) 1 NC_007384.1 Code: MG; COG: COG0451; nucleotide di-P-sugar epimerase or dehydratase 906070 3666344 SSON_0854 Shigella sonnei Ss046 nucleotide di-P-sugar epimerase or dehydratase YP_309832.1 905021 R 300269 CDS YP_309833.1 74311414 3666345 complement(906133..907563) 1 NC_007384.1 Code: MG; COG: COG0702; dTDP-glucose enzyme 907563 ybjT 3666345 ybjT Shigella sonnei Ss046 dTDP-glucose enzyme YP_309833.1 906133 R 300269 CDS YP_309834.1 74311415 3666346 complement(907574..908575) 1 NC_007384.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase 908575 ybjU 3666346 ybjU Shigella sonnei Ss046 L-threonine aldolase YP_309834.1 907574 R 300269 CDS YP_309835.1 74311416 3669981 complement(908612..910330) 1 NC_007384.1 catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase 910330 poxB 3669981 poxB Shigella sonnei Ss046 pyruvate dehydrogenase YP_309835.1 908612 R 300269 CDS YP_309836.1 74311417 3669982 complement(910463..911431) 1 NC_007384.1 Code: C; COG: COG1018; HCP oxidoreductase 911431 3669982 SSON_0858 Shigella sonnei Ss046 HCP oxidoreductase YP_309836.1 910463 R 300269 CDS YP_309837.2 161986562 3669983 complement(911443..913095) 1 NC_007384.1 catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase 913095 ybjW 3669983 ybjW Shigella sonnei Ss046 hydroxylamine reductase YP_309837.2 911443 R 300269 CDS YP_309838.1 74311419 3669984 complement(913239..914186) 1 NC_007384.1 Code: S; COG: COG2431; surface protein 914186 ybjE 3669984 ybjE Shigella sonnei Ss046 surface protein YP_309838.1 913239 R 300269 CDS YP_309839.1 74311420 3669986 915182..915685 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 915685 3669986 SSON_0862 Shigella sonnei Ss046 IS1 ORF YP_309839.1 915182 D 300269 CDS YP_309840.1 74311421 3669987 915971..917629 1 NC_007384.1 Code: L; COG: COG3593; hypothetical protein 917629 ybjD 3669987 ybjD Shigella sonnei Ss046 hypothetical protein YP_309840.1 915971 D 300269 CDS YP_309841.1 74311422 3669988 complement(917626..918618) 1 NC_007384.1 Code: S; COG: COG2990; hypothetical protein 918618 ybjX 3669988 ybjX Shigella sonnei Ss046 hypothetical protein YP_309841.1 917626 R 300269 CDS YP_309842.2 161986561 3669989 918733..919848 1 NC_007384.1 confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 919848 3669989 SSON_0865 Shigella sonnei Ss046 macrolide transporter subunit MacA YP_309842.2 918733 D 300269 CDS YP_309843.1 74311424 3669990 919845..921791 1 NC_007384.1 with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease 921791 ybjZ 3669990 ybjZ Shigella sonnei Ss046 macrolide transporter ATP-binding /permease YP_309843.1 919845 D 300269 CDS YP_309844.1 74311425 3669991 complement(921864..922088) 1 NC_007384.1 inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD 922088 cspD 3669991 cspD Shigella sonnei Ss046 stationary phase/starvation inducible regulatory protein CspD YP_309844.1 921864 R 300269 CDS YP_309845.1 74311426 3669992 922493..923731 1 NC_007384.1 Code: L; COG: COG0582; integrase 923731 3669992 SSON_0868 Shigella sonnei Ss046 integrase YP_309845.1 922493 D 300269 CDS YP_309846.1 74311427 3669993 924285..924788 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 924788 3669993 SSON_0869 Shigella sonnei Ss046 IS1 ORF YP_309846.1 924285 D 300269 CDS YP_309847.1 74311428 3669994 925138..925953 1 NC_007384.1 hypothetical protein 925953 3669994 SSON_0870 Shigella sonnei Ss046 hypothetical protein YP_309847.1 925138 D 300269 CDS YP_309848.1 74311429 3669995 926496..926795 1 NC_007384.1 hypothetical protein 926795 3669995 SSON_0871 Shigella sonnei Ss046 hypothetical protein YP_309848.1 926496 D 300269 CDS YP_309849.1 74311430 3669996 926792..928279 1 NC_007384.1 Code: R; COG: COG3378; bacteriophage P4 DNA primase 928279 3669996 SSON_0872 Shigella sonnei Ss046 bacteriophage P4 DNA primase YP_309849.1 926792 D 300269 CDS YP_309850.1 74311431 3669997 928381..928683 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 928683 3669997 SSON_0873 Shigella sonnei Ss046 IS600 ORF1 YP_309850.1 928381 D 300269 CDS YP_309851.1 74311432 3669998 928824..929537 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 929537 3669998 SSON_0874 Shigella sonnei Ss046 IS600 ORF2 YP_309851.1 928824 D 300269 CDS YP_309852.1 74311433 3669999 930165..930410 1 NC_007384.1 hypothetical protein 930410 3669999 SSON_0875 Shigella sonnei Ss046 hypothetical protein YP_309852.1 930165 D 300269 CDS YP_309853.1 74311434 3670580 930407..930829 1 NC_007384.1 Code: L; COG: COG0629; single stranded DNA-binding protein 930829 3670580 SSON_0876 Shigella sonnei Ss046 single stranded DNA-binding protein YP_309853.1 930407 D 300269 CDS YP_309854.1 74311435 3670581 931489..932634 1 NC_007384.1 Code: OU; COG: COG0740; protease/scaffold protein 932634 3670581 SSON_0877 Shigella sonnei Ss046 protease/scaffold protein YP_309854.1 931489 D 300269 CDS YP_309855.1 74311436 3670582 932598..933356 1 NC_007384.1 prophage protein 933356 3670582 SSON_0878 Shigella sonnei Ss046 prophage protein YP_309855.1 932598 D 300269 CDS YP_309856.1 74311437 3670583 933615..933860 1 NC_007384.1 hypothetical protein 933860 3670583 SSON_0879 Shigella sonnei Ss046 hypothetical protein YP_309856.1 933615 D 300269 CDS YP_309857.1 74311438 3670584 933947..935119 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 935119 3670584 SSON_0880 Shigella sonnei Ss046 IS21 ORF1 YP_309857.1 933947 D 300269 CDS YP_309858.1 74311439 3670585 935119..935916 1 NC_007384.1 Code: L; COG: COG1484; IS21 ORF2 935916 3670585 SSON_0881 Shigella sonnei Ss046 IS21 ORF2 YP_309858.1 935119 D 300269 CDS YP_309859.1 74311440 3670586 936670..936990 1 NC_007384.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 936990 clpS 3670586 clpS Shigella sonnei Ss046 ATP-dependent Clp protease adaptor protein ClpS YP_309859.1 936670 D 300269 CDS YP_309860.1 74311441 3670587 937021..939297 1 NC_007384.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit 939297 clpA 3670587 clpA Shigella sonnei Ss046 ATP-dependent Clp protease ATP-binding subunit YP_309860.1 937021 D 300269 CDS YP_309861.1 74311442 3670589 complement(940044..940262) 1 NC_007384.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 940262 infA 3670589 infA Shigella sonnei Ss046 translation initiation factor IF-1 YP_309861.1 940044 R 300269 CDS YP_309862.1 74311443 3670590 complement(940547..941251) 1 NC_007384.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase 941251 aat 3670590 aat Shigella sonnei Ss046 leucyl/phenylalanyl-tRNA--protein transferase YP_309862.1 940547 R 300269 CDS YP_309863.1 74311444 3670591 complement(941293..943014) 1 NC_007384.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 943014 cydC 3670591 cydC Shigella sonnei Ss046 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_309863.1 941293 R 300269 CDS YP_309864.1 74311445 3670592 complement(943015..944781) 1 NC_007384.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 944781 cydD 3670592 cydD Shigella sonnei Ss046 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_309864.1 943015 R 300269 CDS YP_309865.1 74311446 3670593 complement(944904..945869) 1 NC_007384.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase 945869 trxB 3670593 trxB Shigella sonnei Ss046 thioredoxin reductase YP_309865.1 944904 R 300269 CDS YP_309866.1 74311447 3670594 946414..946908 1 NC_007384.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 946908 lrp 3670594 lrp Shigella sonnei Ss046 leucine-responsive transcriptional regulator YP_309866.1 946414 D 300269 CDS YP_309867.1 74311448 3670595 947043..951110 1 NC_007384.1 DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 951110 ftsK 3670595 ftsK Shigella sonnei Ss046 DNA translocase FtsK YP_309867.1 947043 D 300269 CDS YP_309868.1 74311449 3670596 951262..951876 1 NC_007384.1 participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 951876 lolA 3670596 lolA Shigella sonnei Ss046 outer-membrane lipoprotein carrier protein YP_309868.1 951262 D 300269 CDS YP_309869.1 74311450 3670597 951887..953230 1 NC_007384.1 Code: L; COG: COG2256; recombination factor protein RarA 953230 ycaJ 3670597 ycaJ Shigella sonnei Ss046 recombination factor protein RarA YP_309869.1 951887 D 300269 CDS YP_309870.1 74311451 3670598 953321..954613 1 NC_007384.1 also charges selenocystein tRNA with serine; catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 954613 serS 3670598 serS Shigella sonnei Ss046 seryl-tRNA synthetase YP_309870.1 953321 D 300269 CDS YP_309871.1 74311452 3670329 954939..957296 1 NC_007384.1 Code: C; COG: COG0243; anaerobic dimethyl sulfoxide reductase subunit A 957296 dmsA 3670329 dmsA Shigella sonnei Ss046 anaerobic dimethyl sulfoxide reductase subunit A YP_309871.1 954939 D 300269 CDS YP_309872.1 74311453 3670330 957307..957924 1 NC_007384.1 Code: C; COG: COG0437; anaerobic dimethyl sulfoxide reductase subunit B 957924 dmsB 3670330 dmsB Shigella sonnei Ss046 anaerobic dimethyl sulfoxide reductase subunit B YP_309872.1 957307 D 300269 CDS YP_309873.1 74311454 3670331 957926..958789 1 NC_007384.1 Code: R; COG: COG3302; anaerobic dimethyl sulfoxide reductase subunit C 958789 dmsC 3670331 dmsC Shigella sonnei Ss046 anaerobic dimethyl sulfoxide reductase subunit C YP_309873.1 957926 D 300269 CDS YP_309874.1 74311455 3670332 complement(958825..959451) 1 NC_007384.1 Code: Q; COG: COG1335; hypothetical protein 959451 ycaC 3670332 ycaC Shigella sonnei Ss046 hypothetical protein YP_309874.1 958825 R 300269 CDS YP_309875.1 74311456 3670333 959766..960914 1 NC_007384.1 Code: GEPR; COG: COG0477; MFS family transporter protein 960914 ycaD 3670333 ycaD Shigella sonnei Ss046 MFS family transporter protein YP_309875.1 959766 D 300269 CDS YP_309876.1 74311457 3670335 963055..963558 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 963558 3670335 SSON_0901 Shigella sonnei Ss046 IS1 ORF YP_309876.1 963055 D 300269 CDS YP_309877.1 74311458 3670337 complement(964609..965349) 1 NC_007384.1 activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 965349 pflA 3670337 pflA Shigella sonnei Ss046 pyruvate formate lyase-activating enzyme 1 YP_309877.1 964609 R 300269 CDS YP_309878.1 74311459 3670338 complement(965541..967823) 1 NC_007384.1 Code: C; COG: COG1882; formate acetyltransferase 1 967823 pflB 3670338 pflB Shigella sonnei Ss046 formate acetyltransferase 1 YP_309878.1 965541 R 300269 CDS YP_309879.1 74311460 3670339 complement(967878..968735) 1 NC_007384.1 formate channel 1; Code: P; COG: COG2116; formate transporter 968735 focA 3670339 focA Shigella sonnei Ss046 formate transporter YP_309879.1 967878 R 300269 CDS YP_309880.1 74311461 3670340 complement(969141..970910) 1 NC_007384.1 Code: S; COG: COG1944; hypothetical protein 970910 ycaO 3670340 ycaO Shigella sonnei Ss046 hypothetical protein YP_309880.1 969141 R 300269 CDS YP_309881.1 74311462 3670341 971031..971723 1 NC_007384.1 Code: S; COG: COG2323; hypothetical protein 971723 ycaP 3670341 ycaP Shigella sonnei Ss046 hypothetical protein YP_309881.1 971031 D 300269 CDS YP_309882.1 74311463 3670342 971922..973010 1 NC_007384.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 973010 serC 3670342 serC Shigella sonnei Ss046 phosphoserine aminotransferase YP_309882.1 971922 D 300269 CDS YP_309883.1 74311464 3670343 973081..974364 1 NC_007384.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 974364 aroA 3670343 aroA Shigella sonnei Ss046 3-phosphoshikimate 1-carboxyvinyltransferase YP_309883.1 973081 D 300269 CDS YP_309884.1 74311465 3670344 974490..975836 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 975836 3670344 SSON_0910 Shigella sonnei Ss046 IS4 orf YP_309884.1 974490 D 300269 CDS YP_309885.1 74311466 3670345 975948..976736 1 NC_007384.1 Code: O; COG: COG0501; heat shock protein 976736 ycaL 3670345 ycaL Shigella sonnei Ss046 heat shock protein YP_309885.1 975948 D 300269 CDS YP_309886.1 74311467 3670346 976909..977592 1 NC_007384.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 977592 cmk 3670346 cmk Shigella sonnei Ss046 cytidylate kinase YP_309886.1 976909 D 300269 CDS YP_309887.1 74311468 3670347 977703..979376 1 NC_007384.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 979376 rpsA 3670347 rpsA Shigella sonnei Ss046 30S ribosomal protein S1 YP_309887.1 977703 D 300269 CDS YP_309888.1 74311469 3670406 979536..979820 1 NC_007384.1 site-specific recombination; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 979820 ihfB 3670406 ihfB Shigella sonnei Ss046 integration host factor subunit beta YP_309888.1 979536 D 300269 CDS YP_309889.2 161986560 3670407 980027..982291 1 NC_007384.1 Code: R; COG: COG0658; hypothetical protein 982291 ycaI 3670407 ycaI Shigella sonnei Ss046 hypothetical protein YP_309889.2 980027 D 300269 CDS YP_309890.1 74311471 3670408 982328..984076 1 NC_007384.1 multicopy suppressor of htrB; involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding protein/permease 984076 msbA 3670408 msbA Shigella sonnei Ss046 lipid transporter ATP-binding protein/permease YP_309890.1 982328 D 300269 CDS YP_309891.1 74311472 3670409 984073..985059 1 NC_007384.1 EC 1.2 enzyme; transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 985059 lpxK 3670409 lpxK Shigella sonnei Ss046 tetraacyldisaccharide 4'-kinase YP_309891.1 984073 D 300269 CDS YP_309892.1 74311473 3670410 985096..986328 1 NC_007384.1 Code: S; COG: COG3214; hypothetical protein 986328 ycaQ 3670410 ycaQ Shigella sonnei Ss046 hypothetical protein YP_309892.1 985096 D 300269 CDS YP_309893.1 74311474 3670411 986380..986562 1 NC_007384.1 Code: S; COG: COG2835; hypothetical protein 986562 ycaR 3670411 ycaR Shigella sonnei Ss046 hypothetical protein YP_309893.1 986380 D 300269 CDS YP_309894.1 74311475 3670412 986559..987305 1 NC_007384.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 987305 kdsB 3670412 kdsB Shigella sonnei Ss046 3-deoxy-manno-octulosonate cytidylyltransferase YP_309894.1 986559 D 300269 CDS YP_309895.1 74311476 3670413 987459..988352 1 NC_007384.1 hypothetical protein 988352 3670413 SSON_0921 Shigella sonnei Ss046 hypothetical protein YP_309895.1 987459 D 300269 CDS YP_309896.1 74311477 3670414 complement(988329..989108) 1 NC_007384.1 Code: S; COG: COG1434; hypothetical protein 989108 ycbC 3670414 ycbC Shigella sonnei Ss046 hypothetical protein YP_309896.1 988329 R 300269 CDS YP_309897.1 74311478 3670415 989244..990029 1 NC_007384.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; metallothionein SmtA 990029 smtA 3670415 smtA Shigella sonnei Ss046 metallothionein SmtA YP_309897.1 989244 D 300269 CDS YP_309898.1 74311479 3670416 990026..991348 1 NC_007384.1 killing factor KICB; acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 991348 mukF 3670416 mukF Shigella sonnei Ss046 condesin subunit F YP_309898.1 990026 D 300269 CDS YP_309899.1 74311480 3670417 991356..992033 1 NC_007384.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 992033 mukE 3670417 mukE Shigella sonnei Ss046 condesin subunit E YP_309899.1 991356 D 300269 CDS YP_309900.1 74311481 3670418 992033..996493 1 NC_007384.1 involved in chromosome partitioning; SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 996493 mukB 3670418 mukB Shigella sonnei Ss046 cell division protein MukB YP_309900.1 992033 D 300269 CDS YP_309901.1 74311482 3670419 996638..997984 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 997984 3670419 SSON_0927 Shigella sonnei Ss046 IS4 orf YP_309901.1 996638 D 300269 CDS YP_309902.1 74311483 3670420 998192..1000039 1 NC_007384.1 Code: S; COG: COG2989; hypothetical protein 1000039 ycbB 3670420 ycbB Shigella sonnei Ss046 hypothetical protein YP_309902.1 998192 D 300269 CDS YP_309903.1 74311484 3670421 1000220..1000768 1 NC_007384.1 Code: S; COG: COG3108; hypothetical protein 1000768 ycbK 3670421 ycbK Shigella sonnei Ss046 hypothetical protein YP_309903.1 1000220 D 300269 CDS YP_309904.1 74311485 3670422 1000795..1001442 1 NC_007384.1 Code: R; COG: COG0491; hypothetical protein 1001442 ycbL 3670422 ycbL Shigella sonnei Ss046 hypothetical protein YP_309904.1 1000795 D 300269 CDS YP_309905.1 74311486 3670423 complement(1001664..1002854) 1 NC_007384.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 1002854 aspC 3670423 aspC Shigella sonnei Ss046 aromatic amino acid aminotransferase YP_309905.1 1001664 R 300269 CDS YP_309906.1 74311487 3670424 complement(1003039..1004127) 1 NC_007384.1 outer membrane porin F; 1a; Ia; b; outer membrane protein F 1004127 ompF 3670424 ompF Shigella sonnei Ss046 outer membrane protein F YP_309906.1 1003039 R 300269 CDS YP_309907.1 74311488 3670425 complement(1004729..1006129) 1 NC_007384.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 1006129 asnC 3670425 asnC Shigella sonnei Ss046 asparaginyl-tRNA synthetase YP_309907.1 1004729 R 300269 CDS YP_309908.1 74311489 3670310 complement(1006301..1007503) 1 NC_007384.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1007503 pncB 3670310 pncB Shigella sonnei Ss046 nicotinate phosphoribosyltransferase YP_309908.1 1006301 R 300269 CDS YP_309909.1 74311490 3670311 1007769..1010381 1 NC_007384.1 Code: E; COG: COG0308; aminopeptidase 1010381 pepN 3670311 pepN Shigella sonnei Ss046 aminopeptidase YP_309909.1 1007769 D 300269 CDS YP_309910.1 74311491 3670312 complement(1010588..1011355) 1 NC_007384.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease; aliphatic sulfonates transport ATP-binding subunit 1011355 ssuB 3670312 ssuB Shigella sonnei Ss046 aliphatic sulfonates transport ATP-binding subunit YP_309910.1 1010588 R 300269 CDS YP_309911.1 74311492 3670313 complement(1011352..1012143) 1 NC_007384.1 part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter permease 1012143 ssuC 3670313 ssuC Shigella sonnei Ss046 alkanesulfonate transporter permease YP_309911.1 1011352 R 300269 CDS YP_309912.2 161986559 3670315 complement(1013299..1014258) 1 NC_007384.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit 1014258 ycbO 3670315 ycbO Shigella sonnei Ss046 alkanesulfonate transporter substrate-binding subunit YP_309912.2 1013299 R 300269 CDS YP_309913.1 74311494 3670316 complement(1014251..1014826) 1 NC_007384.1 Code: R; COG: COG0431; NAD(P)H-dependent FMN reductase 1014826 ycbP 3670316 ycbP Shigella sonnei Ss046 NAD(P)H-dependent FMN reductase YP_309913.1 1014251 R 300269 CDS YP_309914.1 74311495 3670317 1015398..1015901 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1015901 3670317 SSON_0941 Shigella sonnei Ss046 IS1 ORF YP_309914.1 1015398 D 300269 CDS YP_309915.1 74311496 3670318 1015950..1016501 1 NC_007384.1 Code: NU; COG: COG3539; fimbrial-like protein 1016501 ycbQ 3670318 ycbQ Shigella sonnei Ss046 fimbrial-like protein YP_309915.1 1015950 D 300269 CDS YP_309916.1 74311497 3670319 1016584..1017285 1 NC_007384.1 Code: NU; COG: COG3121; chaperone 1017285 ycbR 3670319 ycbR Shigella sonnei Ss046 chaperone YP_309916.1 1016584 D 300269 CDS YP_309917.1 74311498 3670321 1019900..1020970 1 NC_007384.1 similar to Salmonella FimH protein; Code: NU; COG: COG3539; FimH-like protein 1020970 3670321 SSON_0945 Shigella sonnei Ss046 FimH-like protein YP_309917.1 1019900 D 300269 CDS YP_309918.1 74311499 3670322 1020982..1021524 1 NC_007384.1 Code: NU; COG: COG3539; fimbrial-like protein 1021524 3670322 SSON_0946 Shigella sonnei Ss046 fimbrial-like protein YP_309918.1 1020982 D 300269 CDS YP_309919.1 74311500 3670323 1021484..1022047 1 NC_007384.1 Code: NU; COG: COG3539; fimbrial-like protein 1022047 3670323 SSON_0947 Shigella sonnei Ss046 fimbrial-like protein YP_309919.1 1021484 D 300269 CDS YP_309920.1 74311501 3670324 1022013..1022750 1 NC_007384.1 Code: NU; COG: COG3121; pili assembly chaperone 1022750 ycbF 3670324 ycbF Shigella sonnei Ss046 pili assembly chaperone YP_309920.1 1022013 D 300269 CDS YP_309921.1 74311502 3670325 1022861..1023871 1 NC_007384.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1023871 pyrD 3670325 pyrD Shigella sonnei Ss046 dihydroorotate dehydrogenase 2 YP_309921.1 1022861 D 300269 CDS YP_309922.1 74311503 3670326 1024009..1024587 1 NC_007384.1 hypothetical protein 1024587 ycbW 3670326 ycbW Shigella sonnei Ss046 hypothetical protein YP_309922.1 1024009 D 300269 CDS YP_309923.1 74311504 3670327 complement(1024584..1025693) 1 NC_007384.1 Code: R; COG: COG3217; hypothetical protein 1025693 3670327 SSON_0951 Shigella sonnei Ss046 hypothetical protein YP_309923.1 1024584 R 300269 CDS YP_309924.1 74311505 3670328 1025937..1028045 1 NC_007384.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 1028045 rlmL 3670328 rlmL Shigella sonnei Ss046 23S rRNA m(2)G2445 methyltransferase YP_309924.1 1025937 D 300269 CDS YP_309925.1 74311506 3666577 1028057..1029964 1 NC_007384.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 1029964 uup 3666577 uup Shigella sonnei Ss046 ABC transporter ATPase YP_309925.1 1028057 D 300269 CDS YP_309926.1 74311507 3666578 1030094..1031347 1 NC_007384.1 Code: S; COG: COG2995; paraquat-inducible protein A 1031347 pqiA 3666578 pqiA Shigella sonnei Ss046 paraquat-inducible protein A YP_309926.1 1030094 D 300269 CDS YP_309927.1 74311508 3666579 1031352..1032992 1 NC_007384.1 Code: R; COG: COG3008; paraquat-inducible protein B 1032992 pqiB 3666579 pqiB Shigella sonnei Ss046 paraquat-inducible protein B YP_309927.1 1031352 D 300269 CDS YP_309928.1 74311509 3666580 1033004..1033552 1 NC_007384.1 Code: S; COG: COG3009; hypothetical protein 1033552 ymbA 3666580 ymbA Shigella sonnei Ss046 hypothetical protein YP_309928.1 1033004 D 300269 CDS YP_309929.1 74311510 3666581 1033808..1033975 1 NC_007384.1 Code: J; COG: COG3130; ribosome modulation factor 1033975 rmf 3666581 rmf Shigella sonnei Ss046 ribosome modulation factor YP_309929.1 1033808 D 300269 CDS YP_309930.1 74311511 3666582 complement(1034045..1034563) 1 NC_007384.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-ACP dehydratase 1034563 fabA 3666582 fabA Shigella sonnei Ss046 3-hydroxydecanoyl-ACP dehydratase YP_309930.1 1034045 R 300269 CDS YP_309931.1 74311512 3666583 complement(1034632..1036392) 1 NC_007384.1 Code: O; COG: COG1067; ATP-dependent protease 1036392 3666583 SSON_0959 Shigella sonnei Ss046 ATP-dependent protease YP_309931.1 1034632 R 300269 CDS YP_309932.1 74311513 3666584 1036578..1037030 1 NC_007384.1 Code: S; COG: COG3120; hypothetical protein 1037030 ycbG 3666584 ycbG Shigella sonnei Ss046 hypothetical protein YP_309932.1 1036578 D 300269 CDS YP_309933.1 74311514 3666585 complement(1037106..1038146) 1 NC_007384.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein OmpA 1038146 ompA 3666585 ompA Shigella sonnei Ss046 outer membrane protein OmpA YP_309933.1 1037106 R 300269 CDS YP_309934.1 74311515 3666586 complement(1038501..1039010) 1 NC_007384.1 Code: D; COG: COG5404; SOS cell division inhibitor 1039010 sulA 3666586 sulA Shigella sonnei Ss046 SOS cell division inhibitor YP_309934.1 1038501 R 300269 CDS YP_309935.1 74311516 3666587 1039229..1039858 1 NC_007384.1 Code: K; COG: COG3070; hypothetical protein 1039858 3666587 SSON_0963 Shigella sonnei Ss046 hypothetical protein YP_309935.1 1039229 D 300269 CDS YP_309936.1 74311517 3666588 complement(1039821..1041983) 1 NC_007384.1 Code: S; COG: COG1289; hypothetical protein 1041983 3666588 SSON_0964 Shigella sonnei Ss046 hypothetical protein YP_309936.1 1039821 R 300269 CDS YP_309937.1 74311518 3666589 complement(1041993..1042439) 1 NC_007384.1 Code: S; COG: COG3304; hypothetical protein 1042439 yccF 3666589 yccF Shigella sonnei Ss046 hypothetical protein YP_309937.1 1041993 R 300269 CDS YP_309938.1 74311519 3666590 1042562..1044616 1 NC_007384.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 1044616 helD 3666590 helD Shigella sonnei Ss046 DNA helicase IV YP_309938.1 1042562 D 300269 CDS YP_309939.2 161986558 3666591 complement(1044648..1045106) 1 NC_007384.1 catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 1045106 mgsA 3666591 mgsA Shigella sonnei Ss046 methylglyoxal synthase YP_309939.2 1044648 R 300269 CDS YP_309940.1 74311521 3666592 complement(1045202..1045864) 1 NC_007384.1 Code: S; COG: COG3110; hypothetical protein 1045864 3666592 SSON_0968 Shigella sonnei Ss046 hypothetical protein YP_309940.1 1045202 R 300269 CDS YP_309941.1 74311522 3666593 complement(1045942..1046445) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1046445 3666593 SSON_0969 Shigella sonnei Ss046 IS1 ORF YP_309941.1 1045942 R 300269 CDS YP_309942.1 74311523 3666594 1046733..1047227 1 NC_007384.1 Code: R; COG: COG1832; hypothetical protein 1047227 3666594 SSON_0970 Shigella sonnei Ss046 hypothetical protein YP_309942.1 1046733 D 300269 CDS YP_309943.1 74311524 3666595 complement(1047272..1047640) 1 NC_007384.1 Code: S; COG: COG3785; heat shock protein HspQ 1047640 yccV 3666595 yccV Shigella sonnei Ss046 heat shock protein HspQ YP_309943.1 1047272 R 300269 CDS YP_309944.1 74311525 3669944 1048932..1049210 1 NC_007384.1 catalyzes the hydrolysis of acylphosphate; acylphosphatase 1049210 3669944 SSON_0973 Shigella sonnei Ss046 acylphosphatase YP_309944.1 1048932 D 300269 CDS YP_309945.2 161986557 3669945 complement(1049207..1049536) 1 NC_007384.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE 1049536 yccK 3669945 yccK Shigella sonnei Ss046 sulfur transfer protein TusE YP_309945.2 1049207 R 300269 CDS YP_309946.1 74311527 3669946 complement(1049627..1050286) 1 NC_007384.1 Code: R; COG: COG0670; hypothetical protein 1050286 yccA 3669946 yccA Shigella sonnei Ss046 hypothetical protein YP_309946.1 1049627 R 300269 CDS YP_309947.1 74311528 3669948 1051003..1051587 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1051587 3669948 SSON_0977 Shigella sonnei Ss046 IS1 ORF YP_309947.1 1051003 D 300269 CDS YP_309948.1 74311529 3669949 1051783..1052901 1 NC_007384.1 Code: C; COG: COG1740; hydrogenase-1 small subunit 1052901 hyaA 3669949 hyaA Shigella sonnei Ss046 hydrogenase-1 small subunit YP_309948.1 1051783 D 300269 CDS YP_309949.1 74311530 3669950 1052898..1054691 1 NC_007384.1 involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit 1054691 hyaB 3669950 hyaB Shigella sonnei Ss046 hydrogenase 1 large subunit YP_309949.1 1052898 D 300269 CDS YP_309950.1 74311531 3669952 1055413..1056000 1 NC_007384.1 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 1056000 hyaD 3669952 hyaD Shigella sonnei Ss046 hydrogenase 1 maturation protease YP_309950.1 1055413 D 300269 CDS YP_309951.1 74311532 3669953 1055997..1056335 1 NC_007384.1 involved in processing hydrogenase proteins HyaA and HyaB; hydrogenase-1 operon protein HyaE 1056335 hyaE 3669953 hyaE Shigella sonnei Ss046 hydrogenase-1 operon protein HyaE YP_309951.1 1055997 D 300269 CDS YP_309952.1 74311533 3669954 1056392..1057249 1 NC_007384.1 nickel incorporation into hydrogenase-1 protein 1057249 hyaF 3669954 hyaF Shigella sonnei Ss046 nickel incorporation into hydrogenase-1 protein YP_309952.1 1056392 D 300269 CDS YP_309953.1 74311534 3669955 1057383..1058927 1 NC_007384.1 Code: C; COG: COG1271; third cytochrome oxidase subunit I 1058927 appC 3669955 appC Shigella sonnei Ss046 third cytochrome oxidase subunit I YP_309953.1 1057383 D 300269 CDS YP_309954.1 74311535 3669956 1058939..1060075 1 NC_007384.1 Code: C; COG: COG1294; third cytochrome oxidase subunit II 1060075 appB 3669956 appB Shigella sonnei Ss046 third cytochrome oxidase subunit II YP_309954.1 1058939 D 300269 CDS YP_309955.1 74311536 3669957 1060088..1060180 1 NC_007384.1 expressed during stationary phase; hypothetical protein 1060180 yccB 3669957 yccB Shigella sonnei Ss046 hypothetical protein YP_309955.1 1060088 D 300269 CDS YP_309956.1 74311537 3669958 1060260..1061558 1 NC_007384.1 pH 2.5 acid phosphatase; periplasmic; phosphoanhydride phosphorylase 1061558 appA 3669958 appA Shigella sonnei Ss046 phosphoanhydride phosphorylase YP_309956.1 1060260 D 300269 CDS YP_309957.1 74311538 3669959 complement(1061673..1063853) 1 NC_007384.1 Code: M; COG: COG3206; cryptic autophosphorylating protein tyrosine kinase Etk 1063853 yccC 3669959 yccC Shigella sonnei Ss046 cryptic autophosphorylating protein tyrosine kinase Etk YP_309957.1 1061673 R 300269 CDS YP_309958.2 161986556 3669960 complement(1063873..1064319) 1 NC_007384.1 Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk; phosphotyrosine-protein phosphatase 1064319 etp 3669960 etp Shigella sonnei Ss046 phosphotyrosine-protein phosphatase YP_309958.2 1063873 R 300269 CDS YP_309959.1 74311540 3669961 complement(1064307..1065446) 1 NC_007384.1 Code: M; COG: COG1596; function in exopolysaccharide production 1065446 yccZ 3669961 yccZ Shigella sonnei Ss046 function in exopolysaccharide production YP_309959.1 1064307 R 300269 CDS YP_309960.1 74311541 3666461 complement(1065492..1067588) 1 NC_007384.1 hypothetical protein 1067588 ymcA 3666461 ymcA Shigella sonnei Ss046 hypothetical protein YP_309960.1 1065492 R 300269 CDS YP_309961.1 74311542 3666462 complement(1067588..1068334) 1 NC_007384.1 hypothetical protein 1068334 ymcB 3666462 ymcB Shigella sonnei Ss046 hypothetical protein YP_309961.1 1067588 R 300269 CDS YP_309962.1 74311543 3666463 complement(1068331..1068975) 1 NC_007384.1 regulator 1068975 ymcC 3666463 ymcC Shigella sonnei Ss046 regulator YP_309962.1 1068331 R 300269 CDS YP_309963.1 74311544 3666464 complement(1069082..1069405) 1 NC_007384.1 hypothetical protein 1069405 ymcD 3666464 ymcD Shigella sonnei Ss046 hypothetical protein YP_309963.1 1069082 R 300269 CDS YP_309964.1 74311545 3666465 complement(1069834..1070046) 1 NC_007384.1 Code: K; COG: COG1278; cold shock-like protein 1070046 cspH 3666465 cspH Shigella sonnei Ss046 cold shock-like protein YP_309964.1 1069834 R 300269 CDS YP_309965.1 74311546 3666466 complement(1070143..1070646) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1070646 3666466 SSON_0996 Shigella sonnei Ss046 IS1 ORF YP_309965.1 1070143 R 300269 CDS YP_309966.1 74311547 3666467 1071109..1071321 1 NC_007384.1 similar to Salmonella cold shock protein; Code: K; COG: COG1278; cold shock protein CspG 1071321 cspG 3666467 cspG Shigella sonnei Ss046 cold shock protein CspG YP_309966.1 1071109 D 300269 CDS YP_309967.1 74311548 3666468 1071495..1071725 1 NC_007384.1 suppresses fabA and ts growth mutation; cold shock gene 1071725 sfa 3666468 sfa Shigella sonnei Ss046 cold shock gene YP_309967.1 1071495 D 300269 CDS YP_309968.1 74311549 3666469 1071715..1071888 1 NC_007384.1 GnsA 1071888 gnsA 3666469 gnsA Shigella sonnei Ss046 GnsA YP_309968.1 1071715 D 300269 CDS YP_309969.2 161986555 3666471 complement(1073082..1075826) 1 NC_007384.1 regulator TorR; Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide; hybrid sensory histidine kinase TorS 1075826 torS 3666471 torS Shigella sonnei Ss046 hybrid sensory histidine kinase TorS YP_309969.2 1073082 R 300269 CDS YP_309970.1 74311551 3666472 1075909..1076937 1 NC_007384.1 part of regulation of tor operon, periplasmic; periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 1076937 torT 3666472 torT Shigella sonnei Ss046 TMAO reductase system periplasmic protein TorT YP_309970.1 1075909 D 300269 CDS YP_309971.1 74311552 3666473 complement(1076910..1077602) 1 NC_007384.1 sensor TorS; response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR 1077602 torR 3666473 torR Shigella sonnei Ss046 DNA-binding transcriptional regulator TorR YP_309971.1 1076910 R 300269 CDS YP_309972.1 74311553 3666474 1077722..1078894 1 NC_007384.1 Code: C; COG: COG3005; trimethylamine N-oxide reductase, cytochrome c-type subunit 1078894 torC 3666474 torC Shigella sonnei Ss046 trimethylamine N-oxide reductase, cytochrome c-type subunit YP_309972.1 1077722 D 300269 CDS YP_309973.1 74311554 3666477 complement(1081944..1082249) 1 NC_007384.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM 1082249 yccD 3666477 yccD Shigella sonnei Ss046 chaperone-modulator protein CbpM YP_309973.1 1081944 R 300269 CDS YP_309974.1 74311555 3666478 complement(1082249..1083169) 1 NC_007384.1 functions closely related to DnaJ; functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA 1083169 cbpA 3666478 cbpA Shigella sonnei Ss046 curved DNA-binding protein CbpA YP_309974.1 1082249 R 300269 CDS YP_309975.1 74311556 3666479 1083494..1084525 1 NC_007384.1 Code: L; COG: COG3335; IS630 orf 1084525 3666479 SSON_1009 Shigella sonnei Ss046 IS630 orf YP_309975.1 1083494 D 300269 CDS YP_309976.1 74311557 3666480 1084585..1085145 1 NC_007384.1 hypothetical protein 1085145 3666480 SSON_1010 Shigella sonnei Ss046 hypothetical protein YP_309976.1 1084585 D 300269 CDS YP_309977.1 74311558 3670252 1085348..1085731 1 NC_007384.1 hypothetical protein 1085731 3670252 SSON_1011 Shigella sonnei Ss046 hypothetical protein YP_309977.1 1085348 D 300269 CDS YP_309978.1 74311559 3670253 1086025..1087266 1 NC_007384.1 glucose-1-phosphatase/inositol phosphatase 1087266 agp 3670253 agp Shigella sonnei Ss046 glucose-1-phosphatase/inositol phosphatase YP_309978.1 1086025 D 300269 CDS YP_309979.1 74311560 3670254 complement(1087304..1087531) 1 NC_007384.1 hypothetical protein 1087531 yccJ 3670254 yccJ Shigella sonnei Ss046 hypothetical protein YP_309979.1 1087304 R 300269 CDS YP_309980.1 74311561 3670255 complement(1087552..1088157) 1 NC_007384.1 affects association of trp repressor and operator; stationary phase protein that binds TrpR repressor; TrpR binding protein WrbA 1088157 wrbA 3670255 wrbA Shigella sonnei Ss046 TrpR binding protein WrbA YP_309980.1 1087552 R 300269 CDS YP_309981.2 161986554 3670256 1089027..1089932 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1089932 3670256 SSON_1015 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_309981.2 1089027 D 300269 CDS YP_309982.1 74311563 3670257 1089944..1091188 1 NC_007384.1 hypothetical protein 1091188 3670257 SSON_1016 Shigella sonnei Ss046 hypothetical protein YP_309982.1 1089944 D 300269 CDS YP_309983.1 74311564 3670258 complement(1091312..1092067) 1 NC_007384.1 Code: L; COG: COG1484; transposase subunit 1092067 3670258 SSON_1017 Shigella sonnei Ss046 transposase subunit YP_309983.1 1091312 R 300269 CDS YP_309984.1 74311565 3670259 complement(1092084..1093619) 1 NC_007384.1 Code: L; COG: COG4584; transposase 1093619 3670259 SSON_1018 Shigella sonnei Ss046 transposase YP_309984.1 1092084 R 300269 CDS YP_309985.1 74311566 3670260 complement(1094701..1096881) 1 NC_007384.1 hypothetical protein 1096881 3670260 SSON_1019 Shigella sonnei Ss046 hypothetical protein YP_309985.1 1094701 R 300269 CDS YP_309986.1 74311567 3670261 complement(1097211..1097921) 1 NC_007384.1 hypothetical protein 1097921 3670261 SSON_1020 Shigella sonnei Ss046 hypothetical protein YP_309986.1 1097211 R 300269 CDS YP_309987.1 74311568 3670262 complement(1100195..1101148) 1 NC_007384.1 hypothetical protein 1101148 3670262 SSON_1021 Shigella sonnei Ss046 hypothetical protein YP_309987.1 1100195 R 300269 CDS YP_309988.1 74311569 3670263 complement(1101667..1102191) 1 NC_007384.1 DNA methylase 1102191 3670263 SSON_1022 Shigella sonnei Ss046 DNA methylase YP_309988.1 1101667 R 300269 CDS YP_309989.1 74311570 3670264 1103841..1104071 1 NC_007384.1 hypothetical protein 1104071 ycdF 3670264 ycdF Shigella sonnei Ss046 hypothetical protein YP_309989.1 1103841 D 300269 CDS YP_309990.1 74311571 3670265 complement(1104435..1105829) 1 NC_007384.1 Code: F; COG: COG2233; transporter 1105829 ycdG 3670265 ycdG Shigella sonnei Ss046 transporter YP_309990.1 1104435 R 300269 CDS YP_309991.1 74311572 3670266 complement(1105784..1106242) 1 NC_007384.1 Code: R; COG: COG1853; hypothetical protein 1106242 3670266 SSON_1025 Shigella sonnei Ss046 hypothetical protein YP_309991.1 1105784 R 300269 CDS YP_309992.1 74311573 3670267 complement(1106289..1106879) 1 NC_007384.1 Code: C; COG: COG0778; hypothetical protein 1106879 3670267 SSON_1026 Shigella sonnei Ss046 hypothetical protein YP_309992.1 1106289 R 300269 CDS YP_309993.1 74311574 3670268 complement(1106889..1107689) 1 NC_007384.1 Code: R; COG: COG0596; acetyltransferase 1107689 3670268 SSON_1027 Shigella sonnei Ss046 acetyltransferase YP_309993.1 1106889 R 300269 CDS YP_309994.1 74311575 3670000 complement(1108871..1109605) 1 NC_007384.1 Code: Q; COG: COG1335; synthetase 1109605 3670000 SSON_1030 Shigella sonnei Ss046 synthetase YP_309994.1 1108871 R 300269 CDS YP_309995.1 74311576 3670001 complement(1110191..1110694) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1110694 3670001 SSON_1031 Shigella sonnei Ss046 IS1 ORF YP_309995.1 1110191 R 300269 CDS YP_309996.1 74311577 3670003 1111719..1112357 1 NC_007384.1 Code: K; COG: COG1309; tet operon regulator 1112357 ycdC 3670003 ycdC Shigella sonnei Ss046 tet operon regulator YP_309996.1 1111719 D 300269 CDS YP_309997.1 74311578 3670004 complement(1112397..1116359) 1 NC_007384.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein; multifunctional functional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 1116359 putA 3670004 putA Shigella sonnei Ss046 multifunctional functional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase YP_309997.1 1112397 R 300269 CDS YP_309998.1 74311579 3670005 1116781..1118289 1 NC_007384.1 Code: ER; COG: COG0591; major sodium/proline symporter 1118289 putP 3670005 putP Shigella sonnei Ss046 major sodium/proline symporter YP_309998.1 1116781 D 300269 CDS YP_309999.1 74311580 3670006 1118946..1119785 1 NC_007384.1 Code: P; COG: COG0672; high-affinity iron permease 1119785 ycdN 3670006 ycdN Shigella sonnei Ss046 high-affinity iron permease YP_309999.1 1118946 D 300269 CDS YP_310000.1 74311581 3670007 1119843..1120970 1 NC_007384.1 Code: P; COG: COG2822; hypothetical protein 1120970 ycdO 3670007 ycdO Shigella sonnei Ss046 hypothetical protein YP_310000.1 1119843 D 300269 CDS YP_310001.1 74311582 3670008 1120976..1122247 1 NC_007384.1 Code: P; COG: COG2837; hypothetical protein 1122247 ycdB 3670008 ycdB Shigella sonnei Ss046 hypothetical protein YP_310001.1 1120976 D 300269 CDS YP_310002.1 74311583 3670009 1122592..1123656 1 NC_007384.1 may be helicase; induced by P starvation; Code: T; COG: COG1702; hypothetical protein 1123656 phoH 3670009 phoH Shigella sonnei Ss046 hypothetical protein YP_310002.1 1122592 D 300269 CDS YP_310003.1 74311584 3670010 1124237..1124923 1 NC_007384.1 hypothetical protein 1124923 3670010 SSON_1040 Shigella sonnei Ss046 hypothetical protein YP_310003.1 1124237 D 300269 CDS YP_310004.1 74311585 3670012 1125477..1126454 1 NC_007384.1 Code: HE; COG: COG0111; dehydrogenase 1126454 ycdW 3670012 ycdW Shigella sonnei Ss046 dehydrogenase YP_310004.1 1125477 D 300269 CDS YP_310005.1 74311586 3670013 1126509..1127246 1 NC_007384.1 Code: ER; COG: COG1387; hydrolase 1127246 ycdX 3670013 ycdX Shigella sonnei Ss046 hydrolase YP_310005.1 1126509 D 300269 CDS YP_310006.1 74311587 3670014 1127270..1127824 1 NC_007384.1 Code: R; COG: COG3381; oxidoreductase component 1127824 ycdY 3670014 ycdY Shigella sonnei Ss046 oxidoreductase component YP_310006.1 1127270 D 300269 CDS YP_310007.1 74311588 3670015 1127878..1128417 1 NC_007384.1 hypothetical protein 1128417 ycdZ 3670015 ycdZ Shigella sonnei Ss046 hypothetical protein YP_310007.1 1127878 D 300269 CDS YP_310008.1 74311589 3670016 complement(1128482..1129315) 1 NC_007384.1 Code: M; COG: COG1462; curli production assembly/transport component, 2nd curli operon 1129315 csgG 3670016 csgG Shigella sonnei Ss046 curli production assembly/transport component, 2nd curli operon YP_310008.1 1128482 R 300269 CDS YP_310009.1 74311590 3670017 complement(1129342..1129758) 1 NC_007384.1 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF 1129758 csgF 3670017 csgF Shigella sonnei Ss046 curli assembly protein CsgF YP_310009.1 1129342 R 300269 CDS YP_310010.1 74311591 3670018 complement(1129783..1130172) 1 NC_007384.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE 1130172 csgE 3670018 csgE Shigella sonnei Ss046 curli assembly protein CsgE YP_310010.1 1129783 R 300269 CDS YP_310011.1 74311592 3670019 1130941..1131444 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1131444 3670019 SSON_1049 Shigella sonnei Ss046 IS1 ORF YP_310011.1 1130941 D 300269 CDS YP_310012.1 74311593 3670021 1132110..1132613 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1132613 3670021 SSON_1051 Shigella sonnei Ss046 IS1 ORF YP_310012.1 1132110 D 300269 CDS YP_310013.1 74311594 3670022 1133134..1133589 1 NC_007384.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit 1133589 csgB 3670022 csgB Shigella sonnei Ss046 curlin minor subunit YP_310013.1 1133134 D 300269 CDS YP_310014.1 74311595 3670023 1133630..1134082 1 NC_007384.1 coiled surface structures; cryptic; cryptic curlin major subunit 1134082 csgA 3670023 csgA Shigella sonnei Ss046 cryptic curlin major subunit YP_310014.1 1133630 D 300269 CDS YP_310015.1 74311596 3670024 1134198..1135370 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 1135370 3670024 SSON_1054 Shigella sonnei Ss046 IS21 ORF1 YP_310015.1 1134198 D 300269 CDS YP_310016.1 74311597 3670025 1135370..1136167 1 NC_007384.1 Code: L; COG: COG1484; IS21 ORF2 1136167 3670025 SSON_1055 Shigella sonnei Ss046 IS21 ORF2 YP_310016.1 1135370 D 300269 CDS YP_310017.1 74311598 3670026 1136274..1136606 1 NC_007384.1 involved in autoagglutination of curliated cells; not involved in production of curli fibers; autoagglutination protein 1136606 csgC 3670026 csgC Shigella sonnei Ss046 autoagglutination protein YP_310017.1 1136274 D 300269 CDS YP_310018.1 74311599 3670027 1136727..1137038 1 NC_007384.1 hypothetical protein 1137038 3670027 SSON_1057 Shigella sonnei Ss046 hypothetical protein YP_310018.1 1136727 D 300269 CDS YP_310019.1 74311600 3670028 1137133..1137666 1 NC_007384.1 Code: R; COG: COG2110; hypothetical protein 1137666 3670028 SSON_1058 Shigella sonnei Ss046 hypothetical protein YP_310019.1 1137133 D 300269 CDS YP_310020.1 74311601 3670029 1137608..1139089 1 NC_007384.1 Code: I; COG: COG1502; synthase 1139089 ymdC 3670029 ymdC Shigella sonnei Ss046 synthase YP_310020.1 1137608 D 300269 CDS YP_310021.1 74311602 3670030 complement(1139097..1140254) 1 NC_007384.1 required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein 1140254 mdoC 3670030 mdoC Shigella sonnei Ss046 glucans biosynthesis protein YP_310021.1 1139097 R 300269 CDS YP_310022.1 74311603 3670031 1140649..1142184 1 NC_007384.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 1142184 mdoG 3670031 mdoG Shigella sonnei Ss046 glucan biosynthesis protein G YP_310022.1 1140649 D 300269 CDS YP_310023.1 74311604 3670032 1142177..1144720 1 NC_007384.1 synthesis of membrane-derived oligosaccharide (MDO); necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 1144720 mdoH 3670032 mdoH Shigella sonnei Ss046 glucosyltransferase MdoH YP_310023.1 1142177 D 300269 CDS YP_310024.1 74311605 3670033 1144933..1146279 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 1146279 3670033 SSON_1063 Shigella sonnei Ss046 IS4 orf YP_310024.1 1144933 D 300269 CDS YP_310025.1 74311606 3670034 1146332..1146559 1 NC_007384.1 Code: R; COG: COG5645; hypothetical protein 1146559 yceK 3670034 yceK Shigella sonnei Ss046 hypothetical protein YP_310025.1 1146332 D 300269 CDS YP_310026.1 74311607 3670035 complement(1146560..1146937) 1 NC_007384.1 hypothetical protein 1146937 msyB 3670035 msyB Shigella sonnei Ss046 hypothetical protein YP_310026.1 1146560 R 300269 CDS YP_310027.1 74311608 3670036 complement(1146964..1147062) 1 NC_007384.1 hypothetical protein 1147062 3670036 SSON_1066 Shigella sonnei Ss046 hypothetical protein YP_310027.1 1146964 R 300269 CDS YP_310028.1 74311609 3670037 complement(1147017..1148066) 1 NC_007384.1 Code: GEPR; COG: COG0477; transporter 1148066 yceE 3670037 yceE Shigella sonnei Ss046 transporter YP_310028.1 1147017 R 300269 CDS YP_310029.1 74311610 3670096 complement(1149266..1150462) 1 NC_007384.1 Code: L; COG: COG3547; ISSfl2 ORF 1150462 3670096 SSON_1068 Shigella sonnei Ss046 ISSfl2 ORF YP_310029.1 1149266 R 300269 CDS YP_310030.1 74311611 3670097 complement(1150820..1151575) 1 NC_007384.1 Code: L; COG: COG1484; transposase subunit 1151575 3670097 SSON_1069 Shigella sonnei Ss046 transposase subunit YP_310030.1 1150820 R 300269 CDS YP_310031.1 74311612 3670098 complement(1151592..1153127) 1 NC_007384.1 Code: L; COG: COG4584; transposase 1153127 3670098 SSON_1070 Shigella sonnei Ss046 transposase YP_310031.1 1151592 R 300269 CDS YP_310032.2 161986553 3670099 complement(1154015..1154920) 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1154920 3670099 SSON_1071 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_310032.2 1154015 R 300269 CDS YP_310033.1 74311614 3670100 complement(1154878..1155243) 1 NC_007384.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1155243 3670100 SSON_1072 Shigella sonnei Ss046 insertion sequence 2 OrfA protein YP_310033.1 1154878 R 300269 CDS YP_310034.1 74311615 3670101 1155526..1155966 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1155966 3670101 SSON_1073 Shigella sonnei Ss046 IS600 ORF2 YP_310034.1 1155526 D 300269 CDS YP_310035.1 74311616 3670102 complement(1156514..1157434) 1 NC_007384.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 1157434 htrB 3670102 htrB Shigella sonnei Ss046 lipid A biosynthesis lauroyl acyltransferase YP_310035.1 1156514 R 300269 CDS YP_310036.1 74311617 3670103 1157659..1158711 1 NC_007384.1 Code: R; COG: COG1054; hypothetical protein 1158711 yceA 3670103 yceA Shigella sonnei Ss046 hypothetical protein YP_310036.1 1157659 D 300269 CDS YP_310037.1 74311618 3670104 complement(1158753..1159328) 1 NC_007384.1 Code: S; COG: COG2353; hypothetical protein 1159328 yceI 3670104 yceI Shigella sonnei Ss046 hypothetical protein YP_310037.1 1158753 R 300269 CDS YP_310038.1 74311619 3670105 complement(1159332..1159898) 1 NC_007384.1 Code: C; COG: COG3038; cytochrome 1159898 3670105 SSON_1077 Shigella sonnei Ss046 cytochrome YP_310038.1 1159332 R 300269 CDS YP_310039.1 74311620 3670106 1160176..1160679 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1160679 3670106 SSON_1078 Shigella sonnei Ss046 IS1 ORF YP_310039.1 1160176 D 300269 CDS YP_310040.1 74311621 3670107 complement(1160770..1161888) 1 NC_007384.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase 1161888 solA 3670107 solA Shigella sonnei Ss046 N-methyltryptophan oxidase YP_310040.1 1160770 R 300269 CDS YP_310041.1 74311622 3670108 complement(1162003..1162257) 1 NC_007384.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS 1162257 bssS 3670108 bssS Shigella sonnei Ss046 biofilm formation regulatory protein BssS YP_310041.1 1162003 R 300269 CDS YP_310042.1 74311623 3670109 complement(1162547..1162792) 1 NC_007384.1 DNA damage-inducible protein I 1162792 dinI 3670109 dinI Shigella sonnei Ss046 DNA damage-inducible protein I YP_310042.1 1162547 R 300269 CDS YP_310043.1 74311624 3670110 complement(1162866..1163912) 1 NC_007384.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1163912 pyrC 3670110 pyrC Shigella sonnei Ss046 dihydroorotase YP_310043.1 1162866 R 300269 CDS YP_310044.1 74311625 3670111 complement(1164018..1164578) 1 NC_007384.1 hypothetical protein 1164578 yceB 3670111 yceB Shigella sonnei Ss046 hypothetical protein YP_310044.1 1164018 R 300269 CDS YP_310045.1 74311626 3670112 complement(1164712..1165359) 1 NC_007384.1 cofactor involved in the reduction of disulfides; glutaredoxin 1165359 grxB 3670112 grxB Shigella sonnei Ss046 glutaredoxin YP_310045.1 1164712 R 300269 CDS YP_310046.2 161986552 3670113 complement(1165423..1166631) 1 NC_007384.1 Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH 1166631 yceL 3670113 yceL Shigella sonnei Ss046 multidrug resistance protein MdtH YP_310046.2 1165423 R 300269 CDS YP_310047.1 74311628 3670114 1166867..1167451 1 NC_007384.1 Code: J; COG: COG1670; ribosomal-protein-S5-alanine N-acetyltransferase 1167451 rimJ 3670114 rimJ Shigella sonnei Ss046 ribosomal-protein-S5-alanine N-acetyltransferase YP_310047.1 1166867 D 300269 CDS YP_310048.1 74311629 3670115 1167462..1168109 1 NC_007384.1 Code: S; COG: COG3132; hypothetical protein 1168109 yceH 3670115 yceH Shigella sonnei Ss046 hypothetical protein YP_310048.1 1167462 D 300269 CDS YP_310049.1 74311630 3670136 1168111..1169034 1 NC_007384.1 Code: R; COG: COG0673; virulence factor 1169034 mviM 3670136 mviM Shigella sonnei Ss046 virulence factor YP_310049.1 1168111 D 300269 CDS YP_310050.1 74311631 3670137 1169144..1170679 1 NC_007384.1 Code: R; COG: COG0728; virulence factor 1170679 mviN 3670137 mviN Shigella sonnei Ss046 virulence factor YP_310050.1 1169144 D 300269 CDS YP_310051.1 74311632 3670138 complement(1170719..1171135) 1 NC_007384.1 Code: NUO; COG: COG3418; protein of flagellar biosynthesis 1171135 flgN 3670138 flgN Shigella sonnei Ss046 protein of flagellar biosynthesis YP_310051.1 1170719 R 300269 CDS YP_310052.1 74311633 3670139 complement(1171140..1171433) 1 NC_007384.1 regulates the flagellar specific sigma28 transcription factor; anti-sigma-28 factor FlgM 1171433 flgM 3670139 flgM Shigella sonnei Ss046 anti-sigma-28 factor FlgM YP_310052.1 1171140 R 300269 CDS YP_310053.1 74311634 3670140 complement(1171509..1172168) 1 NC_007384.1 required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA 1172168 flgA 3670140 flgA Shigella sonnei Ss046 flagellar basal body P-ring biosynthesis protein FlgA YP_310053.1 1171509 R 300269 CDS YP_310054.1 74311635 3670141 1172323..1172739 1 NC_007384.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal-body rod protein FlgB 1172739 flgB 3670141 flgB Shigella sonnei Ss046 flagellar basal-body rod protein FlgB YP_310054.1 1172323 D 300269 CDS YP_310055.1 74311636 3670142 1172743..1173147 1 NC_007384.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 1173147 flgC 3670142 flgC Shigella sonnei Ss046 flagellar basal body rod protein FlgC YP_310055.1 1172743 D 300269 CDS YP_310056.1 74311637 3670143 1173159..1173854 1 NC_007384.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein 1173854 flgD 3670143 flgD Shigella sonnei Ss046 flagellar basal body rod modification protein YP_310056.1 1173159 D 300269 CDS YP_310057.1 74311638 3670144 1173879..1175084 1 NC_007384.1 the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 1175084 flgE 3670144 flgE Shigella sonnei Ss046 flagellar hook protein FlgE YP_310057.1 1173879 D 300269 CDS YP_310058.1 74311639 3670145 1175104..1175859 1 NC_007384.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF 1175859 flgF 3670145 flgF Shigella sonnei Ss046 flagellar basal body rod protein FlgF YP_310058.1 1175104 D 300269 CDS YP_310059.1 74311640 3670147 1176856..1177554 1 NC_007384.1 lipopolysaccharide layer ring protein; part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 1177554 flgH 3670147 flgH Shigella sonnei Ss046 flagellar basal body L-ring protein YP_310059.1 1176856 D 300269 CDS YP_310060.1 74311641 3670148 1177566..1178663 1 NC_007384.1 similar to Salmonella P-ring of flagella basal body; part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring biosynthesis protein FlgA 1178663 flgI 3670148 flgI Shigella sonnei Ss046 flagellar basal body P-ring biosynthesis protein FlgA YP_310060.1 1177566 D 300269 CDS YP_310061.1 74311642 3670149 1178663..1179604 1 NC_007384.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 1179604 flgJ 3670149 flgJ Shigella sonnei Ss046 flagellar rod assembly protein/muramidase FlgJ YP_310061.1 1178663 D 300269 CDS YP_310062.1 74311643 3670150 1179670..1181313 1 NC_007384.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 1181313 flgK 3670150 flgK Shigella sonnei Ss046 flagellar hook-associated protein FlgK YP_310062.1 1179670 D 300269 CDS YP_310063.1 74311644 3670151 1181325..1182278 1 NC_007384.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; flagellar hook-associated protein FlgL 1182278 flgL 3670151 flgL Shigella sonnei Ss046 flagellar hook-associated protein FlgL YP_310063.1 1181325 D 300269 CDS YP_310064.1 74311645 3670152 complement(1182473..1185658) 1 NC_007384.1 membrane attachment; mRNA turnover; maturation 5S RNA; bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E 1185658 rne 3670152 rne Shigella sonnei Ss046 ribonuclease E YP_310064.1 1182473 R 300269 CDS YP_310065.1 74311646 3670153 1185739..1186113 1 NC_007384.1 hypothetical protein 1186113 3670153 SSON_1105 Shigella sonnei Ss046 hypothetical protein YP_310065.1 1185739 D 300269 CDS YP_310066.1 74311647 3670154 1186231..1187190 1 NC_007384.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 1187190 yceC 3670154 yceC Shigella sonnei Ss046 23S rRNA pseudouridylate synthase C YP_310066.1 1186231 D 300269 CDS YP_310067.2 161986551 3670155 complement(1187302..1187886) 1 NC_007384.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 1187886 yceF 3670155 yceF Shigella sonnei Ss046 Maf-like protein YP_310067.2 1187302 R 300269 CDS YP_310068.1 74311649 3670156 1188085..1188606 1 NC_007384.1 Code: R; COG: COG1399; hypothetical protein 1188606 yceD 3670156 yceD Shigella sonnei Ss046 hypothetical protein YP_310068.1 1188085 D 300269 CDS YP_310069.1 74311650 3670157 1188658..1188831 1 NC_007384.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1188831 rpmF 3670157 rpmF Shigella sonnei Ss046 50S ribosomal protein L32 YP_310069.1 1188658 D 300269 CDS YP_310070.2 161986550 3670158 1188912..1189982 1 NC_007384.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 1189982 plsX 3670158 plsX Shigella sonnei Ss046 glycerol-3-phosphate acyltransferase PlsX YP_310070.2 1188912 D 300269 CDS YP_310071.1 74311652 3670159 1190050..1191003 1 NC_007384.1 acetylCoA ACP transacylase; FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 1191003 fabH 3670159 fabH Shigella sonnei Ss046 3-oxoacyl-ACP synthase YP_310071.1 1190050 D 300269 CDS YP_310072.1 74311653 3670160 1191019..1191948 1 NC_007384.1 Code: I; COG: COG0331; malonyl CoA-ACP transacylase 1191948 fabD 3670160 fabD Shigella sonnei Ss046 malonyl CoA-ACP transacylase YP_310072.1 1191019 D 300269 CDS YP_310073.1 74311654 3670161 1191961..1192695 1 NC_007384.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1192695 fabG 3670161 fabG Shigella sonnei Ss046 3-ketoacyl-ACP reductase YP_310073.1 1191961 D 300269 CDS YP_310074.1 74311655 3670162 1192906..1193142 1 NC_007384.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1193142 acpP 3670162 acpP Shigella sonnei Ss046 acyl carrier protein YP_310074.1 1192906 D 300269 CDS YP_310075.1 74311656 3670163 1193230..1194471 1 NC_007384.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1194471 fabF 3670163 fabF Shigella sonnei Ss046 3-oxoacyl-ACP synthase YP_310075.1 1193230 D 300269 CDS YP_310076.1 74311657 3670164 1194591..1195400 1 NC_007384.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 1195400 pabC 3670164 pabC Shigella sonnei Ss046 4-amino-4-deoxychorismate lyase YP_310076.1 1194591 D 300269 CDS YP_310077.1 74311658 3670165 1195403..1196425 1 NC_007384.1 Code: R; COG: COG1559; hypothetical protein 1196425 yceG 3670165 yceG Shigella sonnei Ss046 hypothetical protein YP_310077.1 1195403 D 300269 CDS YP_310078.1 74311659 3670166 1196415..1197056 1 NC_007384.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1197056 tmk 3670166 tmk Shigella sonnei Ss046 thymidylate kinase YP_310078.1 1196415 D 300269 CDS YP_310079.1 74311660 3670167 1197053..1198057 1 NC_007384.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1198057 holB 3670167 holB Shigella sonnei Ss046 DNA polymerase III subunit delta' YP_310079.1 1197053 D 300269 CDS YP_310080.1 74311661 3670168 1198068..1198865 1 NC_007384.1 Code: L; COG: COG0084; metallodependent hydrolase 1198865 ycfH 3670168 ycfH Shigella sonnei Ss046 metallodependent hydrolase YP_310080.1 1198068 D 300269 CDS YP_310081.1 74311662 3670169 1199160..1200593 1 NC_007384.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunit IIBC 1200593 ptsG 3670169 ptsG Shigella sonnei Ss046 PTS system glucose-specific transporter subunit IIBC YP_310081.1 1199160 D 300269 CDS YP_310082.1 74311663 3670170 complement(1200653..1202842) 1 NC_007384.1 Code: P; COG: COG4773; ferric-rhodotorulic acid outer membrane transporter 1202842 fhuE 3670170 fhuE Shigella sonnei Ss046 ferric-rhodotorulic acid outer membrane transporter YP_310082.1 1200653 R 300269 CDS YP_310083.1 74311664 3670171 1203176..1203535 1 NC_007384.1 Code: FGR; COG: COG0537; purine nucleoside phosphoramidase 1203535 ycfF 3670171 ycfF Shigella sonnei Ss046 purine nucleoside phosphoramidase YP_310083.1 1203176 D 300269 CDS YP_310084.1 74311665 3670172 1203538..1203915 1 NC_007384.1 Code: R; COG: COG5633; hypothetical protein 1203915 ycfL 3670172 ycfL Shigella sonnei Ss046 hypothetical protein YP_310084.1 1203538 D 300269 CDS YP_310085.1 74311666 3670173 1203929..1204570 1 NC_007384.1 Code: R; COG: COG3417; hypothetical protein 1204570 ycfM 3670173 ycfM Shigella sonnei Ss046 hypothetical protein YP_310085.1 1203929 D 300269 CDS YP_310086.1 74311667 3670174 1204551..1205375 1 NC_007384.1 catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 1205375 thiK 3670174 thiK Shigella sonnei Ss046 thiamine kinase YP_310086.1 1204551 D 300269 CDS YP_310087.1 74311668 3670291 1205386..1206411 1 NC_007384.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1206411 ycfO 3670291 ycfO Shigella sonnei Ss046 beta-hexosaminidase YP_310087.1 1205386 D 300269 CDS YP_310088.2 161986549 3670292 1206434..1206976 1 NC_007384.1 Code: R; COG: COG3150; hypothetical protein 1206976 ycfP 3670292 ycfP Shigella sonnei Ss046 hypothetical protein YP_310088.2 1206434 D 300269 CDS YP_310089.1 74311670 3670293 1207384..1208688 1 NC_007384.1 Code: C; COG: COG1252; respiratory NADH dehydrogenase 1208688 ndh 3670293 ndh Shigella sonnei Ss046 respiratory NADH dehydrogenase YP_310089.1 1207384 D 300269 CDS YP_310090.1 74311671 3670294 1208915..1209454 1 NC_007384.1 Code: S; COG: COG3134; hypothetical protein 1209454 ycfJ 3670294 ycfJ Shigella sonnei Ss046 hypothetical protein YP_310090.1 1208915 D 300269 CDS YP_310091.1 74311672 3670295 complement(1209516..1210226) 1 NC_007384.1 Code: K; COG: COG1309; hypothetical protein 1210226 ycfQ 3670295 ycfQ Shigella sonnei Ss046 hypothetical protein YP_310091.1 1209516 R 300269 CDS YP_310092.1 74311673 3670296 1210388..1210645 1 NC_007384.1 hypothetical protein 1210645 ycfR 3670296 ycfR Shigella sonnei Ss046 hypothetical protein YP_310092.1 1210388 D 300269 CDS YP_310093.1 74311674 3670297 complement(1210728..1211546) 1 NC_007384.1 Code: S; COG: COG1376; hypothetical protein 1211546 ycfS 3670297 ycfS Shigella sonnei Ss046 hypothetical protein YP_310093.1 1210728 R 300269 CDS YP_310094.1 74311675 3670298 complement(1211828..1215274) 1 NC_007384.1 mutation frequency decline; Code: LK; COG: COG1197; transcription-repair coupling factor 1215274 mfd 3670298 mfd Shigella sonnei Ss046 transcription-repair coupling factor YP_310094.1 1211828 R 300269 CDS YP_310095.1 74311676 3670299 complement(1215402..1216475) 1 NC_007384.1 Code: S; COG: COG4763; hypothetical protein 1216475 ycfT 3670299 ycfT Shigella sonnei Ss046 hypothetical protein YP_310095.1 1215402 R 300269 CDS YP_310096.1 74311677 3670300 1216737..1217936 1 NC_007384.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC 1217936 ycfU 3670300 ycfU Shigella sonnei Ss046 outer membrane-specific lipoprotein transporter subunit LolC YP_310096.1 1216737 D 300269 CDS YP_310097.2 161986548 3670301 1217929..1218630 1 NC_007384.1 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding subunit 1218630 lolD 3670301 lolD Shigella sonnei Ss046 lipoprotein transporter ATP-binding subunit YP_310097.2 1217929 D 300269 CDS YP_310098.1 74311679 3670302 1218630..1219874 1 NC_007384.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1219874 ycfW 3670302 ycfW Shigella sonnei Ss046 outer membrane-specific lipoprotein transporter subunit LolE YP_310098.1 1218630 D 300269 CDS YP_310099.1 74311680 3670303 1219903..1220814 1 NC_007384.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 1220814 ycfX 3670303 ycfX Shigella sonnei Ss046 N-acetyl-D-glucosamine kinase YP_310099.1 1219903 D 300269 CDS YP_310100.1 74311681 3670304 1220830..1221651 1 NC_007384.1 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1221651 cobB 3670304 cobB Shigella sonnei Ss046 NAD-dependent deacetylase YP_310100.1 1220830 D 300269 CDS YP_310101.1 74311682 3670305 complement(1221807..1222853) 1 NC_007384.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter substrate-binding protein 1222853 potD 3670305 potD Shigella sonnei Ss046 spermidine/putrescine ABC transporter substrate-binding protein YP_310101.1 1221807 R 300269 CDS YP_310102.1 74311683 3670306 complement(1222850..1223644) 1 NC_007384.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein 1223644 potC 3670306 potC Shigella sonnei Ss046 spermidine/putrescine ABC transporter membrane protein YP_310102.1 1222850 R 300269 CDS YP_310103.2 161986547 3670307 complement(1223641..1224498) 1 NC_007384.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein 1224498 potB 3670307 potB Shigella sonnei Ss046 spermidine/putrescine ABC transporter membrane protein YP_310103.2 1223641 R 300269 CDS YP_310104.1 74311685 3670308 complement(1224482..1225618) 1 NC_007384.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase 1225618 potA 3670308 potA Shigella sonnei Ss046 putrescine/spermidine ABC transporter ATPase YP_310104.1 1224482 R 300269 CDS YP_310105.1 74311686 3670309 1225868..1227094 1 NC_007384.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1227094 pepT 3670309 pepT Shigella sonnei Ss046 peptidase T YP_310105.1 1225868 D 300269 CDS YP_310106.1 74311687 3670175 complement(1227143..1228273) 1 NC_007384.1 Code: S; COG: COG2850; hypothetical protein 1228273 ycfD 3670175 ycfD Shigella sonnei Ss046 hypothetical protein YP_310106.1 1227143 R 300269 CDS YP_310107.1 74311688 3670176 complement(1228340..1229800) 1 NC_007384.1 Code: T; COG: COG0642; sensor protein PhoQ 1229800 phoQ 3670176 phoQ Shigella sonnei Ss046 sensor protein PhoQ YP_310107.1 1228340 R 300269 CDS YP_310108.1 74311689 3670177 complement(1229800..1230471) 1 NC_007384.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP 1230471 phoP 3670177 phoP Shigella sonnei Ss046 DNA-binding transcriptional regulator PhoP YP_310108.1 1229800 R 300269 CDS YP_310109.1 74311690 3670178 complement(1230639..1232009) 1 NC_007384.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1232009 purB 3670178 purB Shigella sonnei Ss046 adenylosuccinate lyase YP_310109.1 1230639 R 300269 CDS YP_310110.1 74311691 3670179 complement(1232013..1232654) 1 NC_007384.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 1232654 ycfC 3670179 ycfC Shigella sonnei Ss046 hypothetical protein YP_310110.1 1232013 R 300269 CDS YP_310111.2 161986546 3670180 complement(1232690..1233796) 1 NC_007384.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 1233796 mnmA 3670180 mnmA Shigella sonnei Ss046 tRNA-specific 2-thiouridylase MnmA YP_310111.2 1232690 R 300269 CDS YP_310112.1 74311693 3670181 complement(1233850..1234311) 1 NC_007384.1 Code: LR; COG: COG0494; phosphohydrolase 1234311 3670181 SSON_1152 Shigella sonnei Ss046 phosphohydrolase YP_310112.1 1233850 R 300269 CDS YP_310113.1 74311694 3670182 complement(1234321..1234944) 1 NC_007384.1 catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E 1234944 ymfC 3670182 ymfC Shigella sonnei Ss046 23S rRNA pseudouridine synthase E YP_310113.1 1234321 R 300269 CDS YP_310114.1 74311695 3670183 1235146..1236396 1 NC_007384.1 Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1236396 icdA 3670183 icdA Shigella sonnei Ss046 isocitrate dehydrogenase YP_310114.1 1235146 D 300269 CDS YP_310115.1 74311696 3670184 complement(1236499..1236822) 1 NC_007384.1 hypothetical protein 1236822 ycgW 3670184 ycgW Shigella sonnei Ss046 hypothetical protein YP_310115.1 1236499 R 300269 CDS YP_310116.1 74311697 3670185 complement(1237518..1237922) 1 NC_007384.1 Code: R; COG: COG5562; hypothetical protein 1237922 ycgX 3670185 ycgX Shigella sonnei Ss046 hypothetical protein YP_310116.1 1237518 R 300269 CDS YP_310117.1 74311698 3670186 complement(1238143..1238874) 1 NC_007384.1 Code: K; COG: COG0789; transcriptional regulator 1238874 ycgE 3670186 ycgE Shigella sonnei Ss046 transcriptional regulator YP_310117.1 1238143 R 300269 CDS YP_310118.1 74311699 3670188 1240529..1241032 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1241032 3670188 SSON_1159 Shigella sonnei Ss046 IS1 ORF YP_310118.1 1240529 D 300269 CDS YP_310119.2 161986545 3670189 1241774..1242679 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1242679 3670189 SSON_1160 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_310119.2 1241774 D 300269 CDS YP_310120.1 74311701 3670190 complement(1242843..1243178) 1 NC_007384.1 hypothetical protein 1243178 3670190 SSON_1161 Shigella sonnei Ss046 hypothetical protein YP_310120.1 1242843 R 300269 CDS YP_310121.1 74311702 3670191 complement(1243182..1243466) 1 NC_007384.1 hypothetical protein 1243466 3670191 SSON_1162 Shigella sonnei Ss046 hypothetical protein YP_310121.1 1243182 R 300269 CDS YP_310122.1 74311703 3670192 complement(1244546..1244812) 1 NC_007384.1 reverses MinC inhibition of ftsZ ring formation; works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 1244812 minE 3670192 minE Shigella sonnei Ss046 cell division topological specificity factor MinE YP_310122.1 1244546 R 300269 CDS YP_310123.1 74311704 3670193 complement(1244816..1245628) 1 NC_007384.1 a membrane ATPase; activates minC; ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD 1245628 minD 3670193 minD Shigella sonnei Ss046 cell division inhibitor MinD YP_310123.1 1244816 R 300269 CDS YP_310124.1 74311705 3670194 complement(1245652..1246347) 1 NC_007384.1 inhibits ftsZ ring formation; blocks the formation of polar Z-ring septums; septum formation inhibitor 1246347 minC 3670194 minC Shigella sonnei Ss046 septum formation inhibitor YP_310124.1 1245652 R 300269 CDS YP_310125.1 74311706 3670466 1246867..1247235 1 NC_007384.1 hypothetical protein 1247235 ycgJ 3670466 ycgJ Shigella sonnei Ss046 hypothetical protein YP_310125.1 1246867 D 300269 CDS YP_310126.1 74311707 3670467 complement(1247343..1247744) 1 NC_007384.1 hypothetical protein 1247744 ycgK 3670467 ycgK Shigella sonnei Ss046 hypothetical protein YP_310126.1 1247343 R 300269 CDS YP_310127.1 74311708 3670468 1247953..1248279 1 NC_007384.1 Code: S; COG: COG3100; hypothetical protein 1248279 ycgL 3670468 ycgL Shigella sonnei Ss046 hypothetical protein YP_310127.1 1247953 D 300269 CDS YP_310128.1 74311709 3670469 1248351..1249010 1 NC_007384.1 Code: Q; COG: COG0179; hypothetical protein 1249010 ycgM 3670469 ycgM Shigella sonnei Ss046 hypothetical protein YP_310128.1 1248351 D 300269 CDS YP_310129.2 161986544 3670470 1249102..1249548 1 NC_007384.1 Code: S; COG: COG2983; hypothetical protein 1249548 ycgN 3670470 ycgN Shigella sonnei Ss046 hypothetical protein YP_310129.2 1249102 D 300269 CDS YP_310130.1 74311711 3670471 complement(1250337..1250840) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1250840 3670471 SSON_1171 Shigella sonnei Ss046 IS1 ORF YP_310130.1 1250337 R 300269 CDS YP_310131.1 74311712 3670472 complement(1251387..1251890) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1251890 3670472 SSON_1172 Shigella sonnei Ss046 IS1 ORF YP_310131.1 1251387 R 300269 CDS YP_310132.1 74311713 3670474 1252592..1253011 1 NC_007384.1 SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC; binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1253011 umuD 3670474 umuD Shigella sonnei Ss046 DNA polymerase V subunit UmuD YP_310132.1 1252592 D 300269 CDS YP_310133.1 74311714 3670476 complement(1253521..1254717) 1 NC_007384.1 Code: L; COG: COG3547; ISSfl2 ORF 1254717 3670476 SSON_1176 Shigella sonnei Ss046 ISSfl2 ORF YP_310133.1 1253521 R 300269 CDS YP_310134.1 74311715 3670477 complement(1255775..1256305) 1 NC_007384.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 1256305 dsbB 3670477 dsbB Shigella sonnei Ss046 disulfide bond formation protein B YP_310134.1 1255775 R 300269 CDS YP_310135.1 74311716 3670478 complement(1256451..1257992) 1 NC_007384.1 involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter 1257992 nhaB 3670478 nhaB Shigella sonnei Ss046 sodium/proton antiporter YP_310135.1 1256451 R 300269 CDS YP_310136.1 74311717 3670479 1258213..1258932 1 NC_007384.1 Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1258932 fadR 3670479 fadR Shigella sonnei Ss046 fatty acid metabolism regulator YP_310136.1 1258213 D 300269 CDS YP_310137.1 74311718 3670480 complement(1258984..1260516) 1 NC_007384.1 Code: S; COG: COG2719; SpoVR family protein 1260516 ycgB 3670480 ycgB Shigella sonnei Ss046 SpoVR family protein YP_310137.1 1258984 R 300269 CDS YP_310138.1 74311719 3670481 1260846..1262144 1 NC_007384.1 catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1262144 dadA 3670481 dadA Shigella sonnei Ss046 D-amino acid dehydrogenase small subunit YP_310138.1 1260846 D 300269 CDS YP_310139.1 74311720 3670482 1262154..1263224 1 NC_007384.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA; alanine racemase 1263224 dadX 3670482 dadX Shigella sonnei Ss046 alanine racemase YP_310139.1 1262154 D 300269 CDS YP_310140.2 161986543 3670483 complement(1263611..1265347) 1 NC_007384.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter 1265347 ycgO 3670483 ycgO Shigella sonnei Ss046 potassium/proton antiporter YP_310140.2 1263611 R 300269 CDS YP_310141.1 74311723 3670446 complement(1265442..1266356) 1 NC_007384.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A 1266356 ldcA 3670446 ldcA Shigella sonnei Ss046 L,D-carboxypeptidase A YP_310141.1 1265442 R 300269 CDS YP_310142.1 74311722 3670484 1266342..1267067 1 NC_007384.1 Code: M; COG: COG0741; murein transglycosylase E 1267067 mltE 3670484 mltE Shigella sonnei Ss046 murein transglycosylase E YP_310142.1 1266342 D 300269 CDS YP_310143.1 74311724 3670447 complement(1267069..1267803) 1 NC_007384.1 Code: M; COG: COG5581; hypothetical protein 1267803 ycgR 3670447 ycgR Shigella sonnei Ss046 hypothetical protein YP_310143.1 1267069 R 300269 CDS YP_310144.1 74311725 3670448 1267971..1268225 1 NC_007384.1 Code: S; COG: COG2261; transglycosylase associated protein 1268225 ymgE 3670448 ymgE Shigella sonnei Ss046 transglycosylase associated protein YP_310144.1 1267971 D 300269 CDS YP_310145.1 74311726 3670449 1268277..1268579 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1268579 3670449 SSON_1188 Shigella sonnei Ss046 IS600 ORF1 YP_310145.1 1268277 D 300269 CDS YP_310146.1 74311727 3670450 1268720..1269433 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1269433 3670450 SSON_1189 Shigella sonnei Ss046 IS600 ORF2 YP_310146.1 1268720 D 300269 CDS YP_310147.1 74311728 3670452 complement(1270168..1270881) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1270881 3670452 SSON_1191 Shigella sonnei Ss046 IS600 ORF2 YP_310147.1 1270168 R 300269 CDS YP_310148.1 74311729 3670453 complement(1271022..1271324) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1271324 3670453 SSON_1192 Shigella sonnei Ss046 IS600 ORF1 YP_310148.1 1271022 R 300269 CDS YP_310149.1 74311730 3670454 1271890..1273464 1 NC_007384.1 Code: N; COG: COG1344; flagellar filament structural protein 1273464 fliC 3670454 fliC Shigella sonnei Ss046 flagellar filament structural protein YP_310149.1 1271890 D 300269 CDS YP_310150.1 74311731 3670455 1273629..1274348 1 NC_007384.1 flagellar biosynthesis; regulation of flagellar operons; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor 1274348 fliA 3670455 fliA Shigella sonnei Ss046 flagellar biosynthesis sigma factor YP_310150.1 1273629 D 300269 CDS YP_310151.1 74311732 3670457 1274968..1275471 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1275471 3670457 SSON_1196 Shigella sonnei Ss046 IS1 ORF YP_310151.1 1274968 D 300269 CDS YP_310152.1 74311733 3670458 1275810..1276610 1 NC_007384.1 Code: ET; COG: COG0834; cystine transporter subunit 1276610 fliY 3670458 fliY Shigella sonnei Ss046 cystine transporter subunit YP_310152.1 1275810 D 300269 CDS YP_310153.1 74311734 3670459 complement(1276664..1277695) 1 NC_007384.1 Code: L; COG: COG3335; IS630 orf 1277695 3670459 SSON_1198 Shigella sonnei Ss046 IS630 orf YP_310153.1 1276664 R 300269 CDS YP_310154.1 74311735 3670460 1277870..1278856 1 NC_007384.1 catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase 1278856 yedO 3670460 yedO Shigella sonnei Ss046 D-cysteine desulfhydrase YP_310154.1 1277870 D 300269 CDS YP_310155.1 74311736 3670461 1278871..1279539 1 NC_007384.1 Code: E; COG: COG0765; transport system permease 1279539 yecS 3670461 yecS Shigella sonnei Ss046 transport system permease YP_310155.1 1278871 D 300269 CDS YP_310156.1 74311737 3670462 1279536..1280288 1 NC_007384.1 Code: E; COG: COG1126; amino-acid ABC transporter ATP-binding protein YecC 1280288 yecC 3670462 yecC Shigella sonnei Ss046 amino-acid ABC transporter ATP-binding protein YecC YP_310156.1 1279536 D 300269 CDS YP_310157.1 74311738 3670463 1280518..1281240 1 NC_007384.1 regulates genes involved in cell division; DNA-binding transcriptional activator SdiA 1281240 sdiA 3670463 sdiA Shigella sonnei Ss046 DNA-binding transcriptional activator SdiA YP_310157.1 1280518 D 300269 CDS YP_310158.1 74311739 3670464 complement(1281307..1281531) 1 NC_007384.1 hypothetical protein 1281531 yecF 3670464 yecF Shigella sonnei Ss046 hypothetical protein YP_310158.1 1281307 R 300269 CDS YP_310159.1 74311740 3670465 1281990..1282646 1 NC_007384.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator 1282646 uvrY 3670465 uvrY Shigella sonnei Ss046 response regulator YP_310159.1 1281990 D 300269 CDS YP_310160.2 161986542 3670485 1282643..1284475 1 NC_007384.1 repair of UV damage to DNA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1284475 uvrC 3670485 uvrC Shigella sonnei Ss046 excinuclease ABC subunit C YP_310160.2 1282643 D 300269 CDS YP_310161.1 74311742 3670486 1284532..1285080 1 NC_007384.1 Code: I; COG: COG0558; phosphatidylglycerophosphate synthetase 1285080 pgsA 3670486 pgsA Shigella sonnei Ss046 phosphatidylglycerophosphate synthetase YP_310161.1 1284532 D 300269 CDS YP_310162.1 74311743 3670490 1285730..1286395 1 NC_007384.1 Code: R; COG: COG3318; hypothetical protein 1286395 yecA 3670490 yecA Shigella sonnei Ss046 hypothetical protein YP_310162.1 1285730 D 300269 CDS YP_310163.1 74311744 3670491 complement(1286457..1287668) 1 NC_007384.1 Code: E; COG: COG0814; tyrosine-specific transporter 1287668 tyrP 3670491 tyrP Shigella sonnei Ss046 tyrosine-specific transporter YP_310163.1 1286457 R 300269 CDS YP_310164.1 74311745 3670492 1287859..1288098 1 NC_007384.1 hypothetical protein 1288098 yecH 3670492 yecH Shigella sonnei Ss046 hypothetical protein YP_310164.1 1287859 D 300269 CDS YP_310165.1 74311746 3670493 complement(1288136..1288633) 1 NC_007384.1 an iron storage protein; cytoplasmic iron storage protein; ferritin 1288633 ftn 3670493 ftn Shigella sonnei Ss046 ferritin YP_310165.1 1288136 R 300269 CDS YP_310166.1 74311747 3670494 complement(1288804..1289127) 1 NC_007384.1 hypothetical protein 1289127 3670494 SSON_1214 Shigella sonnei Ss046 hypothetical protein YP_310166.1 1288804 R 300269 CDS YP_310168.1 74311749 3670496 complement(1289921..1290424) 1 NC_007384.1 Code: P; COG: COG1528; ferritin 1290424 yecI 3670496 yecI Shigella sonnei Ss046 ferritin YP_310168.1 1289921 R 300269 CDS YP_310169.1 74311750 3670497 1291221..1292210 1 NC_007384.1 Code: G; COG: COG1879; L-arabinose-binding periplasmic protein 1292210 araF 3670497 araF Shigella sonnei Ss046 L-arabinose-binding periplasmic protein YP_310169.1 1291221 D 300269 CDS YP_310170.1 74311751 3670498 1292280..1293794 1 NC_007384.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein 1293794 araG 3670498 araG Shigella sonnei Ss046 L-arabinose transporter ATP-binding protein YP_310170.1 1292280 D 300269 CDS YP_310171.1 74311752 3670499 1293806..1294795 1 NC_007384.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter permease 1294795 araH 3670499 araH Shigella sonnei Ss046 L-arabinose transporter permease YP_310171.1 1293806 D 300269 CDS YP_310172.1 74311753 3670500 1294962..1295762 1 NC_007384.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase 1295762 otsB 3670500 otsB Shigella sonnei Ss046 trehalose-6-phosphate phosphatase YP_310172.1 1294962 D 300269 CDS YP_310173.1 74311754 3669320 1295737..1297161 1 NC_007384.1 Code: G; COG: COG0380; trehalose-6-phosphate synthase 1297161 otsA 3669320 otsA Shigella sonnei Ss046 trehalose-6-phosphate synthase YP_310173.1 1295737 D 300269 CDS YP_310174.1 74311755 3669321 complement(1297168..1297596) 1 NC_007384.1 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspC 1297596 yecG 3669321 yecG Shigella sonnei Ss046 universal stress protein UspC YP_310174.1 1297168 R 300269 CDS YP_310175.1 74311756 3669322 complement(1298395..1299108) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1299108 3669322 SSON_1223 Shigella sonnei Ss046 IS600 ORF2 YP_310175.1 1298395 R 300269 CDS YP_310176.1 74311757 3669323 complement(1299249..1299551) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1299551 3669323 SSON_1224 Shigella sonnei Ss046 IS600 ORF1 YP_310176.1 1299249 R 300269 CDS YP_310177.1 74311758 3669324 1299634..1299993 1 NC_007384.1 acting on class 2 operons; transcriptional initiation factor; with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD 1299993 flhD 3669324 flhD Shigella sonnei Ss046 transcriptional activator FlhD YP_310177.1 1299634 D 300269 CDS YP_310178.1 74311759 3669325 1299996..1300574 1 NC_007384.1 acting on class 2 operons; transcription initiation factor; With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC 1300574 flhC 3669325 flhC Shigella sonnei Ss046 transcriptional activator FlhC YP_310178.1 1299996 D 300269 CDS YP_310179.1 74311760 3669326 1300700..1301587 1 NC_007384.1 no effect on switching; With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA 1301587 motA 3669326 motA Shigella sonnei Ss046 flagellar motor protein MotA YP_310179.1 1300700 D 300269 CDS YP_310180.1 74311761 3669327 1301584..1302510 1 NC_007384.1 enables flagellar motor rotation, linking torque machinery to cell wall; with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB 1302510 motB 3669327 motB Shigella sonnei Ss046 flagellar motor protein MotB YP_310180.1 1301584 D 300269 CDS YP_310181.1 74311762 3669328 1302515..1304479 1 NC_007384.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA 1304479 cheA 3669328 cheA Shigella sonnei Ss046 chemotaxis protein CheA YP_310181.1 1302515 D 300269 CDS YP_310182.1 74311763 3669329 1304500..1305003 1 NC_007384.1 Code: NT; COG: COG0835; purine-binding chemotaxis protein 1305003 cheW 3669329 cheW Shigella sonnei Ss046 purine-binding chemotaxis protein YP_310182.1 1304500 D 300269 CDS YP_310183.1 74311764 3669330 1305148..1306809 1 NC_007384.1 aspartate sensor receptor; Code: NT; COG: COG0840; methyl-accepting chemotaxis protein II 1306809 tar 3669330 tar Shigella sonnei Ss046 methyl-accepting chemotaxis protein II YP_310183.1 1305148 D 300269 CDS YP_310184.1 74311765 3669331 1306855..1308456 1 NC_007384.1 peptide sensor receptor; mediates taxis toward dipeptides; methyl-accepting protein IV 1308456 tap 3669331 tap Shigella sonnei Ss046 methyl-accepting protein IV YP_310184.1 1306855 D 300269 CDS YP_310185.1 74311766 3669332 1308475..1309335 1 NC_007384.1 methylates the MCP; chemotaxis methyltransferase CheR 1309335 cheR 3669332 cheR Shigella sonnei Ss046 chemotaxis methyltransferase CheR YP_310185.1 1308475 D 300269 CDS YP_310186.1 74311767 3669333 1309338..1310387 1 NC_007384.1 cheA sensor; protein methylesterase; regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase 1310387 cheB 3669333 cheB Shigella sonnei Ss046 chemotaxis-specific methylesterase YP_310186.1 1309338 D 300269 CDS YP_310187.1 74311768 3669334 1310402..1310791 1 NC_007384.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY 1310791 cheY 3669334 cheY Shigella sonnei Ss046 chemotaxis regulatory protein CheY YP_310187.1 1310402 D 300269 CDS YP_310188.1 74311769 3669335 1310802..1311446 1 NC_007384.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis regulator CheZ 1311446 cheZ 3669335 cheZ Shigella sonnei Ss046 chemotaxis regulator CheZ YP_310188.1 1310802 D 300269 CDS YP_310189.1 74311770 3669336 complement(1312131..1312544) 1 NC_007384.1 hypothetical protein 1312544 3669336 SSON_1237 Shigella sonnei Ss046 hypothetical protein YP_310189.1 1312131 R 300269 CDS YP_310190.1 74311771 3669337 1312829..1313332 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1313332 3669337 SSON_1238 Shigella sonnei Ss046 IS1 ORF YP_310190.1 1312829 D 300269 CDS YP_310191.1 74311772 3669338 complement(1313343..1313927) 1 NC_007384.1 transposase 1313927 3669338 SSON_1239 Shigella sonnei Ss046 transposase YP_310191.1 1313343 R 300269 CDS YP_310192.1 74311773 3669339 1314044..1315015 1 NC_007384.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB 1315015 flhB 3669339 flhB Shigella sonnei Ss046 flagellar biosynthesis protein FlhB YP_310192.1 1314044 D 300269 CDS YP_310193.1 74311774 3666444 complement(1316621..1318357) 1 NC_007384.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1318357 argS 3666444 argS Shigella sonnei Ss046 arginyl-tRNA synthetase YP_310193.1 1316621 R 300269 CDS YP_310194.1 74311775 3666445 1318567..1319139 1 NC_007384.1 Code: S; COG: COG3102; hypothetical protein 1319139 yecM 3666445 yecM Shigella sonnei Ss046 hypothetical protein YP_310194.1 1318567 D 300269 CDS YP_310195.1 74311776 3666446 1319153..1319899 1 NC_007384.1 Code: P; COG: COG3142; copper homeostasis protein CutC 1319899 cutC 3666446 cutC Shigella sonnei Ss046 copper homeostasis protein CutC YP_310195.1 1319153 D 300269 CDS YP_310196.1 74311777 3666447 1320287..1321387 1 NC_007384.1 Code: C; COG: COG3005; cytochrome C-type protein 1321387 yecK 3666447 yecK Shigella sonnei Ss046 cytochrome C-type protein YP_310196.1 1320287 D 300269 CDS YP_310197.1 74311778 3666448 1321578..1321880 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1321880 3666448 SSON_1246 Shigella sonnei Ss046 IS600 ORF1 YP_310197.1 1321578 D 300269 CDS YP_310198.1 74311779 3666449 1322021..1322734 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1322734 3666449 SSON_1247 Shigella sonnei Ss046 IS600 ORF2 YP_310198.1 1322021 D 300269 CDS YP_310199.1 74311780 3666450 1322817..1325108 1 NC_007384.1 Code: C; COG: COG0243; biotin sulfoxide reductase 1325108 bisZ 3666450 bisZ Shigella sonnei Ss046 biotin sulfoxide reductase YP_310199.1 1322817 D 300269 CDS YP_310200.1 74311781 3666451 complement(1325273..1326244) 1 NC_007384.1 Code: QR; COG: COG0500; hypothetical protein 1326244 yecP 3666451 yecP Shigella sonnei Ss046 hypothetical protein YP_310200.1 1325273 R 300269 CDS YP_310201.1 74311782 3666452 complement(1326241..1326984) 1 NC_007384.1 Code: QR; COG: COG0500; hypothetical protein 1326984 yecO 3666452 yecO Shigella sonnei Ss046 hypothetical protein YP_310201.1 1326241 R 300269 CDS YP_310202.2 161986541 3666453 complement(1327025..1327420) 1 NC_007384.1 Code: R; COG: COG3788; hypothetical protein 1327420 yecN 3666453 yecN Shigella sonnei Ss046 hypothetical protein YP_310202.2 1327025 R 300269 CDS YP_310203.1 74311784 3666455 1328407..1328958 1 NC_007384.1 Code: L; COG: COG1961; resolvase 1328958 3666455 SSON_1253 Shigella sonnei Ss046 resolvase YP_310203.1 1328407 D 300269 CDS YP_310204.1 74311785 3666456 1330868..1331242 1 NC_007384.1 hypothetical protein 1331242 3666456 SSON_1254 Shigella sonnei Ss046 hypothetical protein YP_310204.1 1330868 D 300269 CDS YP_310205.1 74311786 3666457 1334146..1334448 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1334448 3666457 SSON_1255 Shigella sonnei Ss046 IS600 ORF1 YP_310205.1 1334146 D 300269 CDS YP_310206.1 74311787 3666458 1334589..1335302 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1335302 3666458 SSON_1256 Shigella sonnei Ss046 IS600 ORF2 YP_310206.1 1334589 D 300269 CDS YP_310207.1 74311788 3666459 complement(1335299..1335487) 1 NC_007384.1 hypothetical protein 1335487 3666459 SSON_1257 Shigella sonnei Ss046 hypothetical protein YP_310207.1 1335299 R 300269 CDS YP_310208.1 74311789 3666348 complement(1337335..1338189) 1 NC_007384.1 similar to protein of cryptic prophage; antitermination protein Q 1338189 3666348 SSON_1260 Shigella sonnei Ss046 antitermination protein Q YP_310208.1 1337335 R 300269 CDS YP_310209.1 74311790 3666349 complement(1338186..1338560) 1 NC_007384.1 Code: L; COG: COG4570; crossover junction endodeoxyribonuclease 1338560 3666349 SSON_1261 Shigella sonnei Ss046 crossover junction endodeoxyribonuclease YP_310209.1 1338186 R 300269 CDS YP_310210.1 74311791 3666350 complement(1338560..1338817) 1 NC_007384.1 bacteriophage protein 1338817 3666350 SSON_1262 Shigella sonnei Ss046 bacteriophage protein YP_310210.1 1338560 R 300269 CDS YP_310211.1 74311792 3666351 complement(1339152..1339949) 1 NC_007384.1 Code: L; COG: COG1484; IS21 ORF2 1339949 3666351 SSON_1263 Shigella sonnei Ss046 IS21 ORF2 YP_310211.1 1339152 R 300269 CDS YP_310212.1 74311793 3666352 complement(1339949..1341121) 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 1341121 3666352 SSON_1264 Shigella sonnei Ss046 IS21 ORF1 YP_310212.1 1339949 R 300269 CDS YP_310213.1 74311794 3666353 1341140..1341412 1 NC_007384.1 Code: L; COG: COG2963; IS2 orf1 1341412 3666353 SSON_1265 Shigella sonnei Ss046 IS2 orf1 YP_310213.1 1341140 D 300269 CDS YP_310214.2 161986540 3666354 1341370..1342275 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1342275 3666354 SSON_1266 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_310214.2 1341370 D 300269 CDS YP_310215.1 74311796 3666355 1342392..1342694 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1342694 3666355 SSON_1267 Shigella sonnei Ss046 IS600 ORF1 YP_310215.1 1342392 D 300269 CDS YP_310216.1 74311797 3666356 complement(1342857..1343360) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1343360 3666356 SSON_1268 Shigella sonnei Ss046 IS1 ORF YP_310216.1 1342857 R 300269 CDS YP_310217.1 74311798 3666357 1343612..1344325 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1344325 3666357 SSON_1269 Shigella sonnei Ss046 IS600 ORF2 YP_310217.1 1343612 D 300269 CDS YP_310218.1 74311799 3666358 1344353..1345306 1 NC_007384.1 phage tail fiber protein 1345306 3666358 SSON_1270 Shigella sonnei Ss046 phage tail fiber protein YP_310218.1 1344353 D 300269 CDS YP_310219.1 74311800 3666359 1345257..1345880 1 NC_007384.1 hypothetical protein 1345880 3666359 SSON_1271 Shigella sonnei Ss046 hypothetical protein YP_310219.1 1345257 D 300269 CDS YP_310220.1 74311801 3666360 complement(1346060..1347811) 1 NC_007384.1 Code: S; COG: COG4886; invasion plasmid antigen 1347811 ipaH_2 3666360 ipaH_2 Shigella sonnei Ss046 invasion plasmid antigen YP_310220.1 1346060 R 300269 CDS YP_310221.1 74311802 3666361 complement(1348412..1348660) 1 NC_007384.1 hypothetical protein 1348660 3666361 SSON_1273 Shigella sonnei Ss046 hypothetical protein YP_310221.1 1348412 R 300269 CDS YP_310222.2 161986539 3666362 complement(1349015..1349581) 1 NC_007384.1 Code: Q; COG: COG1335; hypothetical protein 1349581 yecD 3666362 yecD Shigella sonnei Ss046 hypothetical protein YP_310222.2 1349015 R 300269 CDS YP_310223.1 74311804 3666363 1349891..1351663 1 NC_007384.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1351663 aspS 3666363 aspS Shigella sonnei Ss046 aspartyl-tRNA synthetase YP_310223.1 1349891 D 300269 CDS YP_310224.1 74311805 3666364 1351781..1352233 1 NC_007384.1 converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 1352233 ntpA 3666364 ntpA Shigella sonnei Ss046 dATP pyrophosphohydrolase YP_310224.1 1351781 D 300269 CDS YP_310225.1 74311806 3666365 1352262..1353002 1 NC_007384.1 Code: S; COG: COG0217; hypothetical protein 1353002 yebC 3666365 yebC Shigella sonnei Ss046 hypothetical protein YP_310225.1 1352262 D 300269 CDS YP_310226.1 74311807 3666539 1353037..1353558 1 NC_007384.1 resolution of structures; repair; endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 1353558 ruvC 3666539 ruvC Shigella sonnei Ss046 Holliday junction resolvase YP_310226.1 1353037 D 300269 CDS YP_310227.2 161986538 3666540 complement(1353560..1354162) 1 NC_007384.1 hypothetical protein 1354162 yebB 3666540 yebB Shigella sonnei Ss046 hypothetical protein YP_310227.2 1353560 R 300269 CDS YP_310228.1 74311809 3666541 1354440..1355051 1 NC_007384.1 branch migration; repair; plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 1355051 ruvA 3666541 ruvA Shigella sonnei Ss046 Holliday junction DNA helicase RuvA YP_310228.1 1354440 D 300269 CDS YP_310229.1 74311810 3666542 1355060..1356070 1 NC_007384.1 branch migration; repair; promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1356070 ruvB 3666542 ruvB Shigella sonnei Ss046 Holliday junction DNA helicase RuvB YP_310229.1 1355060 D 300269 CDS YP_310230.1 74311811 3666543 complement(1356217..1357002) 1 NC_007384.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane protein 1357002 znuB 3666543 znuB Shigella sonnei Ss046 high-affinity zinc transporter membrane protein YP_310230.1 1356217 R 300269 CDS YP_310231.1 74311812 3666544 complement(1356999..1357754) 1 NC_007384.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase 1357754 znuC 3666544 znuC Shigella sonnei Ss046 high-affinity zinc transporter ATPase YP_310231.1 1356999 R 300269 CDS YP_310232.2 161986537 3666545 1357833..1358765 1 NC_007384.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic protein 1358765 znuA 3666545 znuA Shigella sonnei Ss046 high-affinity zinc transporter periplasmic protein YP_310232.2 1357833 D 300269 CDS YP_310233.2 161986536 3666546 1358781..1360103 1 NC_007384.1 Code: M; COG: COG0739; hypothetical protein 1360103 yebA 3666546 yebA Shigella sonnei Ss046 hypothetical protein YP_310233.2 1358781 D 300269 CDS YP_310234.1 74311815 3666547 1360223..1361194 1 NC_007384.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 1361194 msbB 3666547 msbB Shigella sonnei Ss046 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_310234.1 1360223 D 300269 CDS YP_310235.1 74311816 3666548 complement(1361414..1362709) 1 NC_007384.1 hypothetical protein 1362709 3666548 SSON_1287 Shigella sonnei Ss046 hypothetical protein YP_310235.1 1361414 R 300269 CDS YP_310236.1 74311817 3666549 complement(1362755..1363258) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1363258 3666549 SSON_1288 Shigella sonnei Ss046 IS1 ORF YP_310236.1 1362755 R 300269 CDS YP_310237.1 74311818 3666550 complement(1363481..1365133) 1 NC_007384.1 alpha-mannosidase 1365133 3666550 SSON_1289 Shigella sonnei Ss046 alpha-mannosidase YP_310237.1 1363481 R 300269 CDS YP_310238.1 74311819 3666551 complement(1365170..1367038) 1 NC_007384.1 hypothetical protein 1367038 3666551 SSON_1290 Shigella sonnei Ss046 hypothetical protein YP_310238.1 1365170 R 300269 CDS YP_310239.1 74311820 3666552 complement(1367127..1367366) 1 NC_007384.1 hypothetical protein 1367366 3666552 SSON_1291 Shigella sonnei Ss046 hypothetical protein YP_310239.1 1367127 R 300269 CDS YP_310240.1 74311821 3666553 1367682..1368185 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1368185 3666553 SSON_1292 Shigella sonnei Ss046 IS1 ORF YP_310240.1 1367682 D 300269 CDS YP_310241.1 74311822 3666554 1368306..1369148 1 NC_007384.1 hypothetical protein 1369148 3666554 SSON_1293 Shigella sonnei Ss046 hypothetical protein YP_310241.1 1368306 D 300269 CDS YP_310242.1 74311823 3666555 complement(1369208..1370650) 1 NC_007384.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1370650 pykA 3666555 pykA Shigella sonnei Ss046 pyruvate kinase YP_310242.1 1369208 R 300269 CDS YP_310243.1 74311824 3666556 complement(1370778..1371647) 1 NC_007384.1 Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR 1371647 yebK 3666556 yebK Shigella sonnei Ss046 DNA-binding transcriptional regulator HexR YP_310243.1 1370778 R 300269 CDS YP_310244.1 74311825 3666557 1371985..1373460 1 NC_007384.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1373460 zwf 3666557 zwf Shigella sonnei Ss046 glucose-6-phosphate 1-dehydrogenase YP_310244.1 1371985 D 300269 CDS YP_310245.1 74311826 3666671 1373695..1375506 1 NC_007384.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 1375506 edd 3666671 edd Shigella sonnei Ss046 phosphogluconate dehydratase YP_310245.1 1373695 D 300269 CDS YP_310246.1 74311827 3666672 1375543..1376184 1 NC_007384.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 1376184 eda 3666672 eda Shigella sonnei Ss046 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_310246.1 1375543 D 300269 CDS YP_310247.1 74311828 3666673 complement(1376240..1377418) 1 NC_007384.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 1377418 purT 3666673 purT Shigella sonnei Ss046 phosphoribosylglycinamide formyltransferase 2 YP_310247.1 1376240 R 300269 CDS YP_310248.1 74311829 3666674 1377552..1377842 1 NC_007384.1 Code: S; COG: COG3141; DNA damage-inducible protein YebG 1377842 yebG 3666674 yebG Shigella sonnei Ss046 DNA damage-inducible protein YebG YP_310248.1 1377552 D 300269 CDS YP_310249.1 74311830 3666675 1377897..1378265 1 NC_007384.1 secreted protein; unknown function; hypothetical protein 1378265 yebF 3666675 yebF Shigella sonnei Ss046 hypothetical protein YP_310249.1 1377897 D 300269 CDS YP_310250.1 74311831 3666676 1378592..1379251 1 NC_007384.1 Code: S; COG: COG2979; hypothetical protein 1379251 yebE 3666676 yebE Shigella sonnei Ss046 hypothetical protein YP_310250.1 1378592 D 300269 CDS YP_310251.1 74311832 3666677 1379459..1381519 1 NC_007384.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 1381519 ptrB 3666677 ptrB Shigella sonnei Ss046 protease 2 YP_310251.1 1379459 D 300269 CDS YP_310252.1 74311833 3666678 complement(1381516..1382178) 1 NC_007384.1 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 1382178 3666678 SSON_1304 Shigella sonnei Ss046 exodeoxyribonuclease X YP_310252.1 1381516 R 300269 CDS YP_310253.1 74311834 3666679 complement(1382202..1382858) 1 NC_007384.1 Code: R; COG: COG0388; hypothetical protein 1382858 3666679 SSON_1305 Shigella sonnei Ss046 hypothetical protein YP_310253.1 1382202 R 300269 CDS YP_310254.1 74311835 3666680 complement(1382960..1383190) 1 NC_007384.1 DNA polymerase III subunit theta 1383190 holE 3666680 holE Shigella sonnei Ss046 DNA polymerase III subunit theta YP_310254.1 1382960 R 300269 CDS YP_310255.1 74311836 3666681 1383329..1383703 1 NC_007384.1 Code: R; COG: COG2372; hypothetical protein 1383703 3666681 SSON_1307 Shigella sonnei Ss046 hypothetical protein YP_310255.1 1383329 D 300269 CDS YP_310256.1 74311837 3666682 1383707..1384579 1 NC_007384.1 Code: P; COG: COG1276; resistance protein 1384579 3666682 SSON_1308 Shigella sonnei Ss046 resistance protein YP_310256.1 1383707 D 300269 CDS YP_310257.1 74311838 3666683 1384592..1384933 1 NC_007384.1 hypothetical protein 1384933 3666683 SSON_1309 Shigella sonnei Ss046 hypothetical protein YP_310257.1 1384592 D 300269 CDS YP_310258.1 74311839 3666684 complement(1385326..1386402) 1 NC_007384.1 Code: L; COG: COG0582; phage integrase protein 1386402 3666684 SSON_1310 Shigella sonnei Ss046 phage integrase protein YP_310258.1 1385326 R 300269 CDS YP_310259.1 74311840 3666685 complement(1386439..1386684) 1 NC_007384.1 IS1 ORF 1386684 3666685 SSON_1311 Shigella sonnei Ss046 IS1 ORF YP_310259.1 1386439 R 300269 CDS YP_310260.2 161986535 3666686 complement(1386695..1387555) 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1387555 3666686 SSON_1312 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_310260.2 1386695 R 300269 CDS YP_310261.1 74311842 3666687 complement(1387513..1387878) 1 NC_007384.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1387878 3666687 SSON_1313 Shigella sonnei Ss046 insertion sequence 2 OrfA protein YP_310261.1 1387513 R 300269 CDS YP_310262.1 74311843 3666688 complement(1387967..1388233) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1388233 3666688 SSON_1314 Shigella sonnei Ss046 IS1 ORF YP_310262.1 1387967 R 300269 CDS YP_310263.1 74311844 3666689 1388861..1389163 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1389163 3666689 SSON_1315 Shigella sonnei Ss046 IS600 ORF1 YP_310263.1 1388861 D 300269 CDS YP_310264.1 74311845 3666690 1389304..1390017 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1390017 3666690 SSON_1316 Shigella sonnei Ss046 IS600 ORF2 YP_310264.1 1389304 D 300269 CDS YP_310265.1 74311846 3670745 complement(1390133..1391848) 1 NC_007384.1 Code: S; COG: COG4886; invasion plasmid antigen 1391848 ipaH_3 3670745 ipaH_3 Shigella sonnei Ss046 invasion plasmid antigen YP_310265.1 1390133 R 300269 CDS YP_310266.1 74311847 3670746 complement(1392050..1392763) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1392763 3670746 SSON_1318 Shigella sonnei Ss046 IS600 ORF2 YP_310266.1 1392050 R 300269 CDS YP_310267.1 74311848 3670747 complement(1392904..1393206) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1393206 3670747 SSON_1319 Shigella sonnei Ss046 IS600 ORF1 YP_310267.1 1392904 R 300269 CDS YP_310268.1 74311849 3670748 complement(1394044..1394547) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1394547 3670748 SSON_1320 Shigella sonnei Ss046 IS1 ORF YP_310268.1 1394044 R 300269 CDS YP_310269.1 74311850 3670750 1395159..1395461 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1395461 3670750 SSON_1322 Shigella sonnei Ss046 IS600 ORF1 YP_310269.1 1395159 D 300269 CDS YP_310270.1 74311851 3670751 1395602..1396315 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1396315 3670751 SSON_1323 Shigella sonnei Ss046 IS600 ORF2 YP_310270.1 1395602 D 300269 CDS YP_310271.1 74311852 3670752 complement(1396558..1396833) 1 NC_007384.1 hypothetical protein 1396833 3670752 SSON_1324 Shigella sonnei Ss046 hypothetical protein YP_310271.1 1396558 R 300269 CDS YP_310272.1 74311853 3670753 1397264..1397767 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1397767 3670753 SSON_1325 Shigella sonnei Ss046 IS1 ORF YP_310272.1 1397264 D 300269 CDS YP_310273.1 74311854 3670754 complement(1397985..1399430) 1 NC_007384.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF 1399430 yebU 3670754 yebU Shigella sonnei Ss046 rRNA (cytosine-C(5)-)-methyltransferase RsmF YP_310273.1 1397985 R 300269 CDS YP_310274.1 74311855 3670755 complement(1399505..1402144) 1 NC_007384.1 Code: R; COG: COG3008; hypothetical protein 1402144 3670755 SSON_1327 Shigella sonnei Ss046 hypothetical protein YP_310274.1 1399505 R 300269 CDS YP_310275.1 74311856 3670756 complement(1402107..1403390) 1 NC_007384.1 Code: S; COG: COG2995; hypothetical protein 1403390 3670756 SSON_1328 Shigella sonnei Ss046 hypothetical protein YP_310275.1 1402107 R 300269 CDS YP_310276.1 74311857 3670757 1403466..1404017 1 NC_007384.1 Code: T; COG: COG1956; hypothetical protein 1404017 3670757 SSON_1329 Shigella sonnei Ss046 hypothetical protein YP_310276.1 1403466 D 300269 CDS YP_310277.1 74311858 3670758 1404114..1404812 1 NC_007384.1 affects solute and DNA transport through an unknown mechanism; solute/DNA competence effector 1404812 proQ 3670758 proQ Shigella sonnei Ss046 solute/DNA competence effector YP_310277.1 1404114 D 300269 CDS YP_310278.1 74311859 3670759 1404832..1406880 1 NC_007384.1 for penicillin-binding protein 3; Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 1406880 prc 3670759 prc Shigella sonnei Ss046 carboxy-terminal protease YP_310278.1 1404832 D 300269 CDS YP_310279.1 74311860 3670760 1407072..1407953 1 NC_007384.1 integral membrane protein; metalloprotease; heat shock protein HtpX 1407953 htpX 3670760 htpX Shigella sonnei Ss046 heat shock protein HtpX YP_310279.1 1407072 D 300269 CDS YP_310280.1 74311861 3670762 1409239..1410030 1 NC_007384.1 Code: K; COG: COG1414; regulator 1410030 3670762 SSON_1334 Shigella sonnei Ss046 regulator YP_310280.1 1409239 D 300269 CDS YP_310281.1 74311862 3670763 1410571..1410714 1 NC_007384.1 hypothetical protein 1410714 3670763 SSON_1335 Shigella sonnei Ss046 hypothetical protein YP_310281.1 1410571 D 300269 CDS YP_310282.1 74311863 3670694 1410789..1411076 1 NC_007384.1 hypothetical protein 1411076 3670694 SSON_1336 Shigella sonnei Ss046 hypothetical protein YP_310282.1 1410789 D 300269 CDS YP_310283.1 74311864 3670695 1411903..1412112 1 NC_007384.1 multicopy suppresses mukB mutants, regulator; Code: K; COG: COG1278; cold shock-like protein CspC 1412112 cspC 3670695 cspC Shigella sonnei Ss046 cold shock-like protein CspC YP_310283.1 1411903 D 300269 CDS YP_310284.1 74311865 3670696 1412278..1413087 1 NC_007384.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase 1413087 rrmA 3670696 rrmA Shigella sonnei Ss046 23S rRNA methyltransferase YP_310284.1 1412278 D 300269 CDS YP_310285.1 74311866 3670697 complement(1413084..1413704) 1 NC_007384.1 membrane protein YebN; hypothetical protein 1413704 3670697 SSON_1339 Shigella sonnei Ss046 hypothetical protein YP_310285.1 1413084 R 300269 CDS YP_310286.1 74311867 3670698 complement(1414081..1414539) 1 NC_007384.1 Code: S; COG: COG4811; hypothetical protein 1414539 3670698 SSON_1340 Shigella sonnei Ss046 hypothetical protein YP_310286.1 1414081 R 300269 CDS YP_310287.1 74311868 3670699 complement(1414594..1415454) 1 NC_007384.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 1415454 manZ 3670699 manZ Shigella sonnei Ss046 PTS system mannose-specific transporter subunit IID YP_310287.1 1414594 R 300269 CDS YP_310288.1 74311869 3670700 complement(1415458..1416258) 1 NC_007384.1 Code: G; COG: COG3715; PTS mannose-specific transporter subunit IIC 1416258 manY 3670700 manY Shigella sonnei Ss046 PTS mannose-specific transporter subunit IIC YP_310288.1 1415458 R 300269 CDS YP_310289.1 74311870 3670701 complement(1416321..1417292) 1 NC_007384.1 Code: G; COG: COG3444; PTS mannose-specific transporter subunit IIAB 1417292 manX 3670701 manX Shigella sonnei Ss046 PTS mannose-specific transporter subunit IIAB YP_310289.1 1416321 R 300269 CDS YP_310290.1 74311871 3670702 1417755..1419305 1 NC_007384.1 Code: R; COG: COG1253; transporter 1419305 yoaE 3670702 yoaE Shigella sonnei Ss046 transporter YP_310290.1 1417755 D 300269 CDS YP_310291.1 74311872 3670703 complement(1419309..1420937) 1 NC_007384.1 Code: T; COG: COG2200; hypothetical protein 1420937 3670703 SSON_1345 Shigella sonnei Ss046 hypothetical protein YP_310291.1 1419309 R 300269 CDS YP_310292.1 74311873 3670704 complement(1421038..1422402) 1 NC_007384.1 Code: E; COG: COG1760; L-serine deaminase 1422402 sdaA 3670704 sdaA Shigella sonnei Ss046 L-serine deaminase YP_310292.1 1421038 R 300269 CDS YP_310293.1 74311874 3670705 complement(1422586..1423164) 1 NC_007384.1 Code: LR; COG: COG0494; hypothetical protein 1423164 yeaB 3670705 yeaB Shigella sonnei Ss046 hypothetical protein YP_310293.1 1422586 R 300269 CDS YP_310294.1 74311875 3670706 complement(1423168..1424529) 1 NC_007384.1 Code: EH; COG: COG0147; p-aminobenzoate synthetase, component I 1424529 pabB 3670706 pabB Shigella sonnei Ss046 p-aminobenzoate synthetase, component I YP_310294.1 1423168 R 300269 CDS YP_310295.1 74311876 3670707 1424603..1424782 1 NC_007384.1 Code: S; COG: COG3140; hypothetical protein 1424782 3670707 SSON_1349 Shigella sonnei Ss046 hypothetical protein YP_310295.1 1424603 D 300269 CDS YP_310296.1 74311877 3670708 complement(1424902..1425201) 1 NC_007384.1 hypothetical protein 1425201 3670708 SSON_1350 Shigella sonnei Ss046 hypothetical protein YP_310296.1 1424902 R 300269 CDS YP_310297.1 74311878 3670709 complement(1425274..1425777) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1425777 3670709 SSON_1351 Shigella sonnei Ss046 IS1 ORF YP_310297.1 1425274 R 300269 CDS YP_310298.1 74311879 3670710 complement(1426399..1426791) 1 NC_007384.1 Code: J; COG: COG0251; hypothetical protein 1426791 3670710 SSON_1352 Shigella sonnei Ss046 hypothetical protein YP_310298.1 1426399 R 300269 CDS YP_310299.1 74311880 3670711 1426875..1428785 1 NC_007384.1 Code: KL; COG: COG1199; hypothetical protein 1428785 yoaA 3670711 yoaA Shigella sonnei Ss046 hypothetical protein YP_310299.1 1426875 D 300269 CDS YP_310300.1 74311881 3670712 1428843..1429538 1 NC_007384.1 Code: O; COG: COG1214; hypothetical protein 1429538 yeaZ 3670712 yeaZ Shigella sonnei Ss046 hypothetical protein YP_310300.1 1428843 D 300269 CDS YP_310301.1 74311882 3670713 1429578..1430159 1 NC_007384.1 Code: M; COG: COG3065; outer membrane protein 1430159 3670713 SSON_1355 Shigella sonnei Ss046 outer membrane protein YP_310301.1 1429578 D 300269 CDS YP_310302.1 74311883 3670764 1430364..1432049 1 NC_007384.1 Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1432049 fadD 3670764 fadD Shigella sonnei Ss046 long-chain-fatty-acid--CoA ligase YP_310302.1 1430364 D 300269 CDS YP_310303.1 74311884 3670765 1432119..1433246 1 NC_007384.1 processes tRNA precursor; Code: J; COG: COG0349; ribonuclease D 1433246 rnd 3670765 rnd Shigella sonnei Ss046 ribonuclease D YP_310303.1 1432119 D 300269 CDS YP_310304.1 74311885 3670766 complement(1433300..1434265) 1 NC_007384.1 Code: C; COG: COG1018; diogenase subunit beta 1434265 yeaX 3670766 yeaX Shigella sonnei Ss046 diogenase subunit beta YP_310304.1 1433300 R 300269 CDS YP_310305.1 74311886 3670767 complement(1434321..1435445) 1 NC_007384.1 Code: PR; COG: COG4638; hypothetical protein 1435445 yeaW 3670767 yeaW Shigella sonnei Ss046 hypothetical protein YP_310305.1 1434321 R 300269 CDS YP_310306.1 74311887 3670768 complement(1435477..1436922) 1 NC_007384.1 member of the betaine, carnitine, choline transporter (BCCT) family; unknown function; transporter 1436922 yeaV 3670768 yeaV Shigella sonnei Ss046 transporter YP_310306.1 1435477 R 300269 CDS YP_310307.1 74311888 3670769 complement(1437338..1438423) 1 NC_007384.1 Code: CE; COG: COG0473; tartrate dehydrogenase 1438423 yeaU 3670769 yeaU Shigella sonnei Ss046 tartrate dehydrogenase YP_310307.1 1437338 R 300269 CDS YP_310308.1 74311889 3670770 1438505..1439449 1 NC_007384.1 Code: K; COG: COG0583; LysR family transcriptional regulator 1439449 yeaT 3670770 yeaT Shigella sonnei Ss046 LysR family transcriptional regulator YP_310308.1 1438505 D 300269 CDS YP_310309.1 74311890 3670771 1439576..1440214 1 NC_007384.1 Code: E; COG: COG1280; leucine export protein LeuE 1440214 yeaS 3670771 yeaS Shigella sonnei Ss046 leucine export protein LeuE YP_310309.1 1439576 D 300269 CDS YP_310310.1 74311891 3670772 1440387..1440746 1 NC_007384.1 Code: P; COG: COG3615; hypothetical protein 1440746 yeaR 3670772 yeaR Shigella sonnei Ss046 hypothetical protein YP_310310.1 1440387 D 300269 CDS YP_310311.1 74311892 3670773 1440750..1440932 1 NC_007384.1 hypothetical protein 1440932 yoaG 3670773 yoaG Shigella sonnei Ss046 hypothetical protein YP_310311.1 1440750 D 300269 CDS YP_310312.1 74311893 3670774 1441080..1441328 1 NC_007384.1 Code: S; COG: COG2261; hypothetical protein 1441328 yeaQ 3670774 yeaQ Shigella sonnei Ss046 hypothetical protein YP_310312.1 1441080 D 300269 CDS YP_310313.1 74311894 3670775 complement(1441595..1442749) 1 NC_007384.1 Code: T; COG: COG2203; hypothetical protein 1442749 yeaP 3670775 yeaP Shigella sonnei Ss046 hypothetical protein YP_310313.1 1441595 R 300269 CDS YP_310314.1 74311895 3670776 1442803..1443057 1 NC_007384.1 Code: R; COG: COG3042; hypothetical protein 1443057 yoaF 3670776 yoaF Shigella sonnei Ss046 hypothetical protein YP_310314.1 1442803 D 300269 CDS YP_310315.1 74311896 3670777 complement(1443079..1443447) 1 NC_007384.1 Code: S; COG: COG3189; hypothetical protein 1443447 yeaO 3670777 yeaO Shigella sonnei Ss046 hypothetical protein YP_310315.1 1443079 R 300269 CDS YP_310316.1 74311897 3670778 complement(1443481..1444662) 1 NC_007384.1 Code: P; COG: COG2807; amino acid/amine transport protein 1444662 yeaN 3670778 yeaN Shigella sonnei Ss046 amino acid/amine transport protein YP_310316.1 1443481 R 300269 CDS YP_310317.1 74311898 3670779 1444759..1445580 1 NC_007384.1 Code: K; COG: COG2207; AraC family transcriptional regulator 1445580 yeaM 3670779 yeaM Shigella sonnei Ss046 AraC family transcriptional regulator YP_310317.1 1444759 D 300269 CDS YP_310318.1 74311899 3670780 complement(1445537..1445983) 1 NC_007384.1 Code: S; COG: COG2707; hypothetical protein 1445983 yeaL 3670780 yeaL Shigella sonnei Ss046 hypothetical protein YP_310318.1 1445537 R 300269 CDS YP_310319.1 74311900 3670781 1446105..1446257 1 NC_007384.1 hypothetical protein 1446257 3670781 SSON_1373 Shigella sonnei Ss046 hypothetical protein YP_310319.1 1446105 D 300269 CDS YP_310320.1 74311901 3670782 complement(1446258..1446761) 1 NC_007384.1 Code: S; COG: COG2606; hypothetical protein 1446761 yeaK 3670782 yeaK Shigella sonnei Ss046 hypothetical protein YP_310320.1 1446258 R 300269 CDS YP_310321.1 74311902 3670560 complement(1446804..1448243) 1 NC_007384.1 Code: T; COG: COG2199; hypothetical protein 1448243 yeaJ 3670560 yeaJ Shigella sonnei Ss046 hypothetical protein YP_310321.1 1446804 R 300269 CDS YP_310322.1 74311903 3670561 complement(1448286..1448789) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1448789 3670561 SSON_1376 Shigella sonnei Ss046 IS1 ORF YP_310322.1 1448286 R 300269 CDS YP_310323.1 74311904 3670562 complement(1449251..1450726) 1 NC_007384.1 Code: T; COG: COG2199; hypothetical protein 1450726 yeaI 3670562 yeaI Shigella sonnei Ss046 hypothetical protein YP_310323.1 1449251 R 300269 CDS YP_310324.1 74311905 3670563 complement(1450873..1452156) 1 NC_007384.1 Code: S; COG: COG2718; hypothetical protein 1452156 yeaH 3670563 yeaH Shigella sonnei Ss046 hypothetical protein YP_310324.1 1450873 R 300269 CDS YP_310325.1 74311906 3670564 complement(1452269..1454203) 1 NC_007384.1 Code: T; COG: COG2766; hypothetical protein 1454203 yeaG 3670564 yeaG Shigella sonnei Ss046 hypothetical protein YP_310325.1 1452269 R 300269 CDS YP_310326.1 74311907 3670565 1454639..1455385 1 NC_007384.1 Code: M; COG: COG3713; hypothetical protein 1455385 yeaF 3670565 yeaF Shigella sonnei Ss046 hypothetical protein YP_310326.1 1454639 D 300269 CDS YP_310327.1 74311908 3670566 1455475..1456329 1 NC_007384.1 Code: R; COG: COG0656; aldehyde reductase 1456329 3670566 SSON_1381 Shigella sonnei Ss046 aldehyde reductase YP_310327.1 1455475 D 300269 CDS YP_310328.1 74311909 3670567 complement(1456380..1457285) 1 NC_007384.1 Code: G; COG: COG0676; hypothetical protein 1457285 yeaD 3670567 yeaD Shigella sonnei Ss046 hypothetical protein YP_310328.1 1456380 R 300269 CDS YP_310329.1 74311910 3670568 complement(1457332..1458678) 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 1458678 3670568 SSON_1383 Shigella sonnei Ss046 IS4 orf YP_310329.1 1457332 R 300269 CDS YP_310330.1 74311911 3670569 complement(1458786..1459781) 1 NC_007384.1 Code: G; COG: COG0057; glyceraldehyde-3-phosphate dehydrogenase 1459781 gapA 3670569 gapA Shigella sonnei Ss046 glyceraldehyde-3-phosphate dehydrogenase YP_310330.1 1458786 R 300269 CDS YP_310331.1 74311912 3670570 1460123..1460536 1 NC_007384.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 1460536 yeaA 3670570 yeaA Shigella sonnei Ss046 methionine sulfoxide reductase B YP_310331.1 1460123 D 300269 CDS YP_310332.1 74311913 3670571 1460533..1460850 1 NC_007384.1 Code: S; COG: COG3139; hypothetical protein 1460850 3670571 SSON_1386 Shigella sonnei Ss046 hypothetical protein YP_310332.1 1460533 D 300269 CDS YP_310333.2 161986534 3670572 complement(1461011..1461652) 1 NC_007384.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase 1461652 ydjB 3670572 ydjB Shigella sonnei Ss046 nicotinamidase/pyrazinamidase YP_310333.2 1461011 R 300269 CDS YP_310334.1 74311915 3670573 complement(1461663..1462679) 1 NC_007384.1 converts asparagine to aspartate and ammonia; asparaginase 1462679 ansA 3670573 ansA Shigella sonnei Ss046 asparaginase YP_310334.1 1461663 R 300269 CDS YP_310335.1 74311916 3670574 complement(1462846..1464702) 1 NC_007384.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 1464702 sppA 3670574 sppA Shigella sonnei Ss046 protease 4 YP_310335.1 1462846 R 300269 CDS YP_310336.1 74311917 3670575 1464863..1465414 1 NC_007384.1 Code: C; COG: COG0778; hypothetical protein 1465414 ydjA 3670575 ydjA Shigella sonnei Ss046 hypothetical protein YP_310336.1 1464863 D 300269 CDS YP_310337.1 74311918 3670576 1465531..1466574 1 NC_007384.1 catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 1466574 selD 3670576 selD Shigella sonnei Ss046 selenophosphate synthetase YP_310337.1 1465531 D 300269 CDS YP_310338.1 74311919 3670577 1466579..1468540 1 NC_007384.1 decatenates replicating daughter chromosomes; DNA topoisomerase III 1468540 topB 3670577 topB Shigella sonnei Ss046 DNA topoisomerase III YP_310338.1 1466579 D 300269 CDS YP_310339.1 74311920 3670578 complement(1468588..1469091) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1469091 3670578 SSON_1393 Shigella sonnei Ss046 IS1 ORF YP_310339.1 1468588 R 300269 CDS YP_310340.1 74311921 3670599 complement(1470601..1471944) 1 NC_007384.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1471944 gdhA 3670599 gdhA Shigella sonnei Ss046 glutamate dehydrogenase YP_310340.1 1470601 R 300269 CDS YP_310341.1 74311922 3670600 1472180..1472452 1 NC_007384.1 hypothetical protein 1472452 3670600 SSON_1396 Shigella sonnei Ss046 hypothetical protein YP_310341.1 1472180 D 300269 CDS YP_310342.1 74311923 3670601 complement(1472418..1472825) 1 NC_007384.1 Code: LR; COG: COG0494; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 1472825 3670601 SSON_1397 Shigella sonnei Ss046 pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase YP_310342.1 1472418 R 300269 CDS YP_310343.1 74311924 3670603 1473432..1473935 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1473935 3670603 SSON_1399 Shigella sonnei Ss046 IS1 ORF YP_310343.1 1473432 D 300269 CDS YP_310344.1 74311925 3670604 complement(1474317..1475639) 1 NC_007384.1 Code: P; COG: COG2897; thiosulfate sulfur transferase 1475639 3670604 SSON_1400 Shigella sonnei Ss046 thiosulfate sulfur transferase YP_310344.1 1474317 R 300269 CDS YP_310345.1 74311926 3670605 complement(1475691..1476344) 1 NC_007384.1 Code: R; COG: COG4136; ABC transporter ATP-binding protein 1476344 3670605 SSON_1401 Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_310345.1 1475691 R 300269 CDS YP_310346.1 74311927 3670607 complement(1477853..1479019) 1 NC_007384.1 Code: R; COG: COG4134; ABC transporter substrate-binding protein 1479019 3670607 SSON_1403 Shigella sonnei Ss046 ABC transporter substrate-binding protein YP_310346.1 1477853 R 300269 CDS YP_310347.1 74311928 3670608 complement(1479029..1479577) 1 NC_007384.1 Code: S; COG: COG2128; hypothetical protein 1479577 ynjA 3670608 ynjA Shigella sonnei Ss046 hypothetical protein YP_310347.1 1479029 R 300269 CDS YP_310348.1 74311929 3670609 complement(1479577..1480284) 1 NC_007384.1 Code: S; COG: COG0398; hypothetical protein 1480284 ydjZ 3670609 ydjZ Shigella sonnei Ss046 hypothetical protein YP_310348.1 1479577 R 300269 CDS YP_310349.1 74311930 3670610 complement(1480299..1481138) 1 NC_007384.1 hypothetical protein 1481138 ydjY 3670610 ydjY Shigella sonnei Ss046 hypothetical protein YP_310349.1 1480299 R 300269 CDS YP_310350.1 74311931 3670611 complement(1480981..1481739) 1 NC_007384.1 Code: S; COG: COG0398; hypothetical protein 1481739 ydjX 3670611 ydjX Shigella sonnei Ss046 hypothetical protein YP_310350.1 1480981 R 300269 CDS YP_310351.1 74311932 3670612 complement(1481858..1482664) 1 NC_007384.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 1482664 xthA 3670612 xthA Shigella sonnei Ss046 exonuclease III YP_310351.1 1481858 R 300269 CDS YP_310352.1 74311933 3670613 1483110..1484330 1 NC_007384.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate; bifunctional succinylornithine transaminase/acetylornithine transaminase 1484330 cstC 3670613 cstC Shigella sonnei Ss046 bifunctional succinylornithine transaminase/acetylornithine transaminase YP_310352.1 1483110 D 300269 CDS YP_310353.1 74311934 3670614 1484327..1485361 1 NC_007384.1 Code: E; COG: COG3138; arginine succinyltransferase 1485361 3670614 SSON_1410 Shigella sonnei Ss046 arginine succinyltransferase YP_310353.1 1484327 D 300269 CDS YP_310354.1 74311935 3670616 1486833..1488176 1 NC_007384.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation; succinylarginine dihydrolase 1488176 3670616 SSON_1412 Shigella sonnei Ss046 succinylarginine dihydrolase YP_310354.1 1486833 D 300269 CDS YP_310355.1 74311936 3670617 1488169..1489137 1 NC_007384.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase 1489137 ydjS 3670617 ydjS Shigella sonnei Ss046 succinylglutamate desuccinylase YP_310355.1 1488169 D 300269 CDS YP_310356.1 74311937 3670540 1489467..1489928 1 NC_007384.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; hypothetical protein 1489928 spy 3670540 spy Shigella sonnei Ss046 hypothetical protein YP_310356.1 1489467 D 300269 CDS YP_310357.1 74311938 3670541 1490173..1490676 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1490676 3670541 SSON_1415 Shigella sonnei Ss046 IS1 ORF YP_310357.1 1490173 D 300269 CDS YP_310358.1 74311939 3670542 1490869..1491507 1 NC_007384.1 Code: S; COG: COG3758; hypothetical protein 1491507 3670542 SSON_1416 Shigella sonnei Ss046 hypothetical protein YP_310358.1 1490869 D 300269 CDS YP_310359.1 74311940 3670543 complement(1491467..1492354) 1 NC_007384.1 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease 1492354 3670543 SSON_1417 Shigella sonnei Ss046 nucleotide excision repair endonuclease YP_310359.1 1491467 R 300269 CDS YP_310360.1 74311941 3670544 complement(1492584..1493411) 1 NC_007384.1 prefers NH3 over glutamine; catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1493411 nadE 3670544 nadE Shigella sonnei Ss046 NAD synthetase YP_310360.1 1492584 R 300269 CDS YP_310361.1 74311942 3670545 1493613..1493951 1 NC_007384.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE 1493951 osmE 3670545 osmE Shigella sonnei Ss046 DNA-binding transcriptional activator OsmE YP_310361.1 1493613 D 300269 CDS YP_310362.1 74311943 3670546 1494250..1494570 1 NC_007384.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB 1494570 celA 3670546 celA Shigella sonnei Ss046 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB YP_310362.1 1494250 D 300269 CDS YP_310363.1 74311944 3670547 1494655..1496013 1 NC_007384.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC 1496013 celB 3670547 celB Shigella sonnei Ss046 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC YP_310363.1 1494655 D 300269 CDS YP_310364.1 74311945 3670548 1496064..1496414 1 NC_007384.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA 1496414 celC 3670548 celC Shigella sonnei Ss046 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA YP_310364.1 1496064 D 300269 CDS YP_310365.1 74311946 3670549 1496422..1497264 1 NC_007384.1 represses the celABCDF-ydjC operon involved in carbon uptake; DNA-binding transcriptional regulator ChbR 1497264 celD 3670549 celD Shigella sonnei Ss046 DNA-binding transcriptional regulator ChbR YP_310365.1 1496422 D 300269 CDS YP_310366.1 74311947 3670550 1497369..1498721 1 NC_007384.1 Code: G; COG: COG1486; cryptic phospho-beta-glucosidase 1498721 celF 3670550 celF Shigella sonnei Ss046 cryptic phospho-beta-glucosidase YP_310366.1 1497369 D 300269 CDS YP_310367.1 74311948 3670551 1498734..1499492 1 NC_007384.1 Code: S; COG: COG3394; hypothetical protein 1499492 ydjC 3670551 ydjC Shigella sonnei Ss046 hypothetical protein YP_310367.1 1498734 D 300269 CDS YP_310368.1 74311949 3670552 complement(1499750..1502011) 1 NC_007384.1 hydroperoxidase HPII(III); Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II 1502011 katE 3670552 katE Shigella sonnei Ss046 hydroperoxidase II YP_310368.1 1499750 R 300269 CDS YP_310369.1 74311950 3670553 1502194..1502457 1 NC_007384.1 cell division modulator 1502457 3670553 SSON_1427 Shigella sonnei Ss046 cell division modulator YP_310369.1 1502194 D 300269 CDS YP_310370.1 74311951 3670554 complement(1503554..1504945) 1 NC_007384.1 Code: R; COG: COG1823; kinase fragment 1504945 3670554 SSON_1428 Shigella sonnei Ss046 kinase fragment YP_310370.1 1503554 R 300269 CDS YP_310371.2 161986533 3670555 complement(1505078..1505668) 1 NC_007384.1 Code: R; COG: COG1988; hypothetical protein 1505668 3670555 SSON_1429 Shigella sonnei Ss046 hypothetical protein YP_310371.2 1505078 R 300269 CDS YP_310372.1 74311953 3670556 complement(1505831..1506499) 1 NC_007384.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase 1506499 yniC 3670556 yniC Shigella sonnei Ss046 2-deoxyglucose-6-phosphatase YP_310372.1 1505831 R 300269 CDS YP_310373.1 74311954 3670557 1506646..1507182 1 NC_007384.1 hypothetical protein 1507182 3670557 SSON_1431 Shigella sonnei Ss046 hypothetical protein YP_310373.1 1506646 D 300269 CDS YP_310374.1 74311955 3670558 complement(1507223..1508083) 1 NC_007384.1 Code: G; COG: COG3001; hypothetical protein 1508083 3670558 SSON_1432 Shigella sonnei Ss046 hypothetical protein YP_310374.1 1507223 R 300269 CDS YP_310375.1 74311956 3670559 complement(1508189..1508479) 1 NC_007384.1 hypothetical protein 1508479 3670559 SSON_1433 Shigella sonnei Ss046 hypothetical protein YP_310375.1 1508189 R 300269 CDS YP_310376.1 74311957 3667293 complement(1508580..1509509) 1 NC_007384.1 suppressor of pfkA; Code: G; COG: COG1105; 6-phosphofructokinase 1509509 pfkB 3667293 pfkB Shigella sonnei Ss046 6-phosphofructokinase YP_310376.1 1508580 R 300269 CDS YP_310377.1 74311958 3667294 1509796..1510554 1 NC_007384.1 Code: M; COG: COG3137; hypothetical protein 1510554 3667294 SSON_1435 Shigella sonnei Ss046 hypothetical protein YP_310377.1 1509796 D 300269 CDS YP_310378.1 74311959 3667295 complement(1510607..1510825) 1 NC_007384.1 hypothetical protein 1510825 3667295 SSON_1436 Shigella sonnei Ss046 hypothetical protein YP_310378.1 1510607 R 300269 CDS YP_310379.1 74311960 3667296 1512504..1513007 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1513007 3667296 SSON_1437 Shigella sonnei Ss046 IS1 ORF YP_310379.1 1512504 D 300269 CDS YP_310380.1 74311961 3667298 1514087..1516015 1 NC_007384.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 1516015 thrS 3667298 thrS Shigella sonnei Ss046 threonyl-tRNA synthetase YP_310380.1 1514087 D 300269 CDS YP_310381.1 74311962 3667299 1516127..1516561 1 NC_007384.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1516561 infC 3667299 infC Shigella sonnei Ss046 translation initiation factor IF-3 YP_310381.1 1516127 D 300269 CDS YP_310382.1 74311963 3667300 1516658..1516855 1 NC_007384.1 Code: J; COG: COG0291; 50S ribosomal protein L35 1516855 rpmI 3667300 rpmI Shigella sonnei Ss046 50S ribosomal protein L35 YP_310382.1 1516658 D 300269 CDS YP_310383.1 74311964 3667301 1516908..1517264 1 NC_007384.1 includes regulator; binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1517264 rplT 3667301 rplT Shigella sonnei Ss046 50S ribosomal protein L20 YP_310383.1 1516908 D 300269 CDS YP_310385.1 74311966 3667303 1517714..1518697 1 NC_007384.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1518697 pheS 3667303 pheS Shigella sonnei Ss046 phenylalanyl-tRNA synthetase subunit alpha YP_310385.1 1517714 D 300269 CDS YP_310386.1 74311967 3667304 1518712..1521099 1 NC_007384.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1521099 pheT 3667304 pheT Shigella sonnei Ss046 phenylalanyl-tRNA synthetase subunit beta YP_310386.1 1518712 D 300269 CDS YP_310387.1 74311968 3667305 1521104..1521403 1 NC_007384.1 site specific recombination; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 1521403 ihfA 3667305 ihfA Shigella sonnei Ss046 integration host factor subunit alpha YP_310387.1 1521104 D 300269 CDS YP_310388.1 74311969 3667306 1521504..1522484 1 NC_007384.1 with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease 1522484 btuC 3667306 btuC Shigella sonnei Ss046 vtamin B12-transporter permease YP_310388.1 1521504 D 300269 CDS YP_310389.1 74311970 3667307 1522547..1523098 1 NC_007384.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; glutathione peroxidase 1523098 btuE 3667307 btuE Shigella sonnei Ss046 glutathione peroxidase YP_310389.1 1522547 D 300269 CDS YP_310390.1 74311971 3667308 1523098..1523847 1 NC_007384.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase 1523847 btuD 3667308 btuD Shigella sonnei Ss046 vitamin B12-transporter ATPase YP_310390.1 1523098 D 300269 CDS YP_310391.1 74311972 3667309 1523925..1524389 1 NC_007384.1 Code: M; COG: COG0791; lipoprotein 1524389 nlpC 3667309 nlpC Shigella sonnei Ss046 lipoprotein YP_310391.1 1523925 D 300269 CDS YP_310392.1 74311973 3667310 1524490..1525521 1 NC_007384.1 Code: L; COG: COG3335; IS630 orf 1525521 3667310 SSON_1451 Shigella sonnei Ss046 IS630 orf YP_310392.1 1524490 D 300269 CDS YP_310393.1 74311974 3667311 1525791..1526504 1 NC_007384.1 Code: T; COG: COG2200; hypothetical protein 1526504 3667311 SSON_1452 Shigella sonnei Ss046 hypothetical protein YP_310393.1 1525791 D 300269 CDS YP_310394.1 74311975 3670783 1526567..1528003 1 NC_007384.1 Code: S; COG: COG0397; hypothetical protein 1528003 3670783 SSON_1453 Shigella sonnei Ss046 hypothetical protein YP_310394.1 1526567 D 300269 CDS YP_310395.1 74311976 3670784 complement(1528007..1528198) 1 NC_007384.1 Code: P; COG: COG4256; hypothetical protein 1528198 ydiE 3670784 ydiE Shigella sonnei Ss046 hypothetical protein YP_310395.1 1528007 R 300269 CDS YP_310396.1 74311977 3670785 complement(1528330..1529376) 1 NC_007384.1 DAHP synthetase; tryptophan repressible; tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 1529376 aroH 3670785 aroH Shigella sonnei Ss046 phospho-2-dehydro-3-deoxyheptonate aldolase YP_310396.1 1528330 R 300269 CDS YP_310397.1 74311978 3670786 complement(1529533..1530366) 1 NC_007384.1 Code: S; COG: COG1806; hypothetical protein 1530366 ydiA 3670786 ydiA Shigella sonnei Ss046 hypothetical protein YP_310397.1 1529533 R 300269 CDS YP_310398.1 74311979 3670787 1530699..1533077 1 NC_007384.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase 1533077 ppsA 3670787 ppsA Shigella sonnei Ss046 phosphoenolpyruvate synthase YP_310398.1 1530699 D 300269 CDS YP_310399.1 74311980 3670789 1533749..1534252 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1534252 3670789 SSON_1459 Shigella sonnei Ss046 IS1 ORF YP_310399.1 1533749 D 300269 CDS YP_310400.1 74311981 3670791 complement(1534974..1535732) 1 NC_007384.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1535732 aroD 3670791 aroD Shigella sonnei Ss046 3-dehydroquinate dehydratase YP_310400.1 1534974 R 300269 CDS YP_310401.1 74311982 3670792 complement(1535763..1536629) 1 NC_007384.1 YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase 1536629 ydiB 3670792 ydiB Shigella sonnei Ss046 quinate/shikimate dehydrogenase YP_310401.1 1535763 R 300269 CDS YP_310402.1 74311983 3670793 complement(1536641..1537912) 1 NC_007384.1 Code: GEPR; COG: COG0477; amino acid/amine transport protein 1537912 3670793 SSON_1463 Shigella sonnei Ss046 amino acid/amine transport protein YP_310402.1 1536641 R 300269 CDS YP_310403.1 74311984 3670794 complement(1538477..1538980) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1538980 3670794 SSON_1464 Shigella sonnei Ss046 IS1 ORF YP_310403.1 1538477 R 300269 CDS YP_310404.1 74311985 3670796 complement(1540224..1540607) 1 NC_007384.1 hypothetical protein 1540607 3670796 SSON_1466 Shigella sonnei Ss046 hypothetical protein YP_310404.1 1540224 R 300269 CDS YP_310405.1 74311986 3670797 complement(1540933..1541436) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1541436 3670797 SSON_1467 Shigella sonnei Ss046 IS1 ORF YP_310405.1 1540933 R 300269 CDS YP_310406.1 74311987 3670798 complement(1541786..1542898) 1 NC_007384.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; inner membrane protein 1542898 3670798 SSON_1468 Shigella sonnei Ss046 inner membrane protein YP_310406.1 1541786 R 300269 CDS YP_310407.1 74311988 3670799 1543287..1546343 1 NC_007384.1 Code: C; COG: COG0277; oxidase 1546343 ydiJ 3670799 ydiJ Shigella sonnei Ss046 oxidase YP_310407.1 1543287 D 300269 CDS YP_310408.1 74311989 3670800 1546340..1546750 1 NC_007384.1 Code: Q; COG: COG2050; hypothetical protein 1546750 3670800 SSON_1470 Shigella sonnei Ss046 hypothetical protein YP_310408.1 1546340 D 300269 CDS YP_310409.1 74311990 3670801 1546769..1547038 1 NC_007384.1 hypothetical protein 1547038 3670801 SSON_1471 Shigella sonnei Ss046 hypothetical protein YP_310409.1 1546769 D 300269 CDS YP_310410.1 74311991 3670802 1547586..1547954 1 NC_007384.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein 1547954 sufA 3670802 sufA Shigella sonnei Ss046 iron-sulfur cluster assembly scaffold protein YP_310410.1 1547586 D 300269 CDS YP_310411.1 74311992 3667118 1547924..1549450 1 NC_007384.1 with SufCD activates cysteine desulfurase SufS; cysteine desulfurase 1549450 ynhE 3667118 ynhE Shigella sonnei Ss046 cysteine desulfurase YP_310411.1 1547924 D 300269 CDS YP_310412.1 74311993 3667119 1549460..1550206 1 NC_007384.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase 1550206 sufC 3667119 sufC Shigella sonnei Ss046 cysteine desulfurase YP_310412.1 1549460 D 300269 CDS YP_310413.1 74311994 3667120 1550181..1551452 1 NC_007384.1 with SufBC activates cysteine desulfurase SufS; cysteine desulfurase 1551452 ynhC 3667120 ynhC Shigella sonnei Ss046 cysteine desulfurase YP_310413.1 1550181 D 300269 CDS YP_310414.1 74311995 3667121 1551449..1552669 1 NC_007384.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase 1552669 3667121 SSON_1476 Shigella sonnei Ss046 bifunctional cysteine desulfurase/selenocysteine lyase YP_310414.1 1551449 D 300269 CDS YP_310415.1 74311996 3667122 1552682..1553098 1 NC_007384.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE 1553098 ynhA 3667122 ynhA Shigella sonnei Ss046 cysteine desufuration protein SufE YP_310415.1 1552682 D 300269 CDS YP_310416.1 74311997 3667123 1553247..1554251 1 NC_007384.1 Code: S; COG: COG1376; hypothetical protein 1554251 ynhG 3667123 ynhG Shigella sonnei Ss046 hypothetical protein YP_310416.1 1553247 D 300269 CDS YP_310417.1 74311998 3667124 complement(1554314..1554550) 1 NC_007384.1 Code: M; COG: COG4238; murein lipoprotein 1554550 lpp 3667124 lpp Shigella sonnei Ss046 murein lipoprotein YP_310417.1 1554314 R 300269 CDS YP_310418.1 74311999 3667125 complement(1554860..1556272) 1 NC_007384.1 formerly F; fructose stimulated; catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1556272 pykF 3667125 pykF Shigella sonnei Ss046 pyruvate kinase YP_310418.1 1554860 R 300269 CDS YP_310419.1 74312000 3667126 1556829..1557038 1 NC_007384.1 hypothetical protein 1557038 3667126 SSON_1481 Shigella sonnei Ss046 hypothetical protein YP_310419.1 1556829 D 300269 CDS YP_310420.1 74312001 3667127 1557494..1558120 1 NC_007384.1 Code: C; COG: COG0437; hypothetical protein 1558120 3667127 SSON_1482 Shigella sonnei Ss046 hypothetical protein YP_310420.1 1557494 D 300269 CDS YP_310421.1 74312002 3667128 1558141..1560249 1 NC_007384.1 Code: C; COG: COG2414; oxidoreductase 1560249 3667128 SSON_1483 Shigella sonnei Ss046 oxidoreductase YP_310421.1 1558141 D 300269 CDS YP_310422.1 74312003 3667129 1560253..1560900 1 NC_007384.1 hypothetical protein 1560900 3667129 SSON_1484 Shigella sonnei Ss046 hypothetical protein YP_310422.1 1560253 D 300269 CDS YP_310423.1 74312004 3667130 1560913..1561632 1 NC_007384.1 Code: C; COG: COG0437; oxidoreductase, Fe-S subunit 1561632 3667130 SSON_1485 Shigella sonnei Ss046 oxidoreductase, Fe-S subunit YP_310423.1 1560913 D 300269 CDS YP_310424.1 74312005 3667131 1561629..1562414 1 NC_007384.1 Code: C; COG: COG4117; hypothetical protein 1562414 ydhU 3667131 ydhU Shigella sonnei Ss046 hypothetical protein YP_310424.1 1561629 D 300269 CDS YP_310425.1 74312006 3667132 1562418..1563230 1 NC_007384.1 hypothetical protein 1563230 3667132 SSON_1487 Shigella sonnei Ss046 hypothetical protein YP_310425.1 1562418 D 300269 CDS YP_310426.1 74312007 3667133 complement(1563242..1564846) 1 NC_007384.1 Code: S; COG: COG4529; hypothetical protein 1564846 3667133 SSON_1488 Shigella sonnei Ss046 hypothetical protein YP_310426.1 1563242 R 300269 CDS YP_310427.1 74312008 3667134 complement(1564972..1565277) 1 NC_007384.1 hypothetical protein 1565277 3667134 SSON_1489 Shigella sonnei Ss046 hypothetical protein YP_310427.1 1564972 R 300269 CDS YP_310428.1 74312009 3666598 1565850..1567106 1 NC_007384.1 Code: MU; COG: COG3468; hypothetical protein 1567106 3666598 SSON_1492 Shigella sonnei Ss046 hypothetical protein YP_310428.1 1565850 D 300269 CDS YP_310429.1 74312010 3666599 complement(1567147..1568520) 1 NC_007384.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1568520 ydhE 3666599 ydhE Shigella sonnei Ss046 multidrug efflux protein YP_310429.1 1567147 R 300269 CDS YP_310430.1 74312011 3666600 1568735..1569376 1 NC_007384.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1569376 ribE 3666600 ribE Shigella sonnei Ss046 riboflavin synthase subunit alpha YP_310430.1 1568735 D 300269 CDS YP_310431.1 74312012 3666601 complement(1569416..1570564) 1 NC_007384.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane-fatty-acyl-phospholipid synthase 1570564 cfa 3666601 cfa Shigella sonnei Ss046 cyclopropane-fatty-acyl-phospholipid synthase YP_310431.1 1569416 R 300269 CDS YP_310432.1 74312013 3666602 complement(1570855..1572066) 1 NC_007384.1 uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 1572066 ydhC 3666602 ydhC Shigella sonnei Ss046 inner membrane transport protein YdhC YP_310432.1 1570855 R 300269 CDS YP_310433.1 74312014 3666603 1572179..1573111 1 NC_007384.1 Code: K; COG: COG0583; DNA-binding transcriptional regulator 1573111 ydhB 3666603 ydhB Shigella sonnei Ss046 DNA-binding transcriptional regulator YP_310433.1 1572179 D 300269 CDS YP_310434.1 74312015 3666604 complement(1573108..1574133) 1 NC_007384.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 1574133 purR 3666604 purR Shigella sonnei Ss046 DNA-binding transcriptional repressor PurR YP_310434.1 1573108 R 300269 CDS YP_310435.1 74312016 3666605 1574687..1575856 1 NC_007384.1 Code: G; COG: COG2814; transporter 1575856 3666605 SSON_1499 Shigella sonnei Ss046 transporter YP_310435.1 1574687 D 300269 CDS YP_310436.1 74312017 3666606 complement(1576002..1576583) 1 NC_007384.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 1576583 sodB 3666606 sodB Shigella sonnei Ss046 superoxide dismutase YP_310436.1 1576002 R 300269 CDS YP_310437.1 74312018 3666607 complement(1576711..1577526) 1 NC_007384.1 Code: M; COG: COG0791; lipoprotein 1577526 ydhO 3666607 ydhO Shigella sonnei Ss046 lipoprotein YP_310437.1 1576711 R 300269 CDS YP_310438.1 74312019 3666608 1577860..1578207 1 NC_007384.1 Code: O; COG: COG0278; hypothetical protein 1578207 ydhD 3666608 ydhD Shigella sonnei Ss046 hypothetical protein YP_310438.1 1577860 D 300269 CDS YP_310439.1 74312020 3666610 complement(1582920..1583567) 1 NC_007384.1 degrades tRNA; Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 1583567 rnt 3666610 rnt Shigella sonnei Ss046 ribonuclease T YP_310439.1 1582920 R 300269 CDS YP_310440.1 74312021 3666611 complement(1583670..1584077) 1 NC_007384.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 1584077 gloA 3666611 gloA Shigella sonnei Ss046 glyoxalase I YP_310440.1 1583670 R 300269 CDS YP_310441.1 74312022 3666612 complement(1584158..1585255) 1 NC_007384.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase 1585255 nemA 3666612 nemA Shigella sonnei Ss046 N-ethylmaleimide reductase YP_310441.1 1584158 R 300269 CDS YP_310442.1 74312024 3666614 complement(1585292..1585891) 1 NC_007384.1 Code: K; COG: COG1309; hypothetical protein 1585891 3666614 SSON_1508 Shigella sonnei Ss046 hypothetical protein YP_310442.1 1585292 R 300269 CDS YP_310443.1 74312023 3666613 1585856..1586233 1 NC_007384.1 Code: R; COG: COG3313; hypothetical protein 1586233 3666613 SSON_1507 Shigella sonnei Ss046 hypothetical protein YP_310443.1 1585856 D 300269 CDS YP_310444.1 74312025 3666615 1586282..1587178 1 NC_007384.1 Code: R; COG: COG4989; hypothetical protein 1587178 3666615 SSON_1509 Shigella sonnei Ss046 hypothetical protein YP_310444.1 1586282 D 300269 CDS YP_310445.1 74312026 3667155 1587259..1587780 1 NC_007384.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase 1587780 sodC 3667155 sodC Shigella sonnei Ss046 superoxide dismutase YP_310445.1 1587259 D 300269 CDS YP_310446.1 74312027 3667156 complement(1587781..1589772) 1 NC_007384.1 Code: S; COG: COG1289; hypothetical protein 1589772 3667156 SSON_1511 Shigella sonnei Ss046 hypothetical protein YP_310446.1 1587781 R 300269 CDS YP_310447.1 74312028 3667157 complement(1589793..1590692) 1 NC_007384.1 Code: V; COG: COG1566; hypothetical protein 1590692 3667157 SSON_1512 Shigella sonnei Ss046 hypothetical protein YP_310447.1 1589793 R 300269 CDS YP_310448.1 74312029 3667158 complement(1590653..1590889) 1 NC_007384.1 hypothetical protein 1590889 3667158 SSON_1513 Shigella sonnei Ss046 hypothetical protein YP_310448.1 1590653 R 300269 CDS YP_310449.2 161986532 3667159 1591090..1591524 1 NC_007384.1 Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA 1591524 slyA 3667159 slyA Shigella sonnei Ss046 transcriptional regulator SlyA YP_310449.2 1591090 D 300269 CDS YP_310450.1 74312031 3667160 complement(1591571..1592038) 1 NC_007384.1 Code: M; COG: COG3133; outer membrane protein 1592038 slyB 3667160 slyB Shigella sonnei Ss046 outer membrane protein YP_310450.1 1591571 R 300269 CDS YP_310451.1 74312032 3667161 1592312..1593421 1 NC_007384.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 1593421 anmK 3667161 anmK Shigella sonnei Ss046 anhydro-N-acetylmuramic acid kinase YP_310451.1 1592312 D 300269 CDS YP_310452.1 74312033 3667162 1593600..1593848 1 NC_007384.1 Code: R; COG: COG3895; hypothetical protein 1593848 ydhA 3667162 ydhA Shigella sonnei Ss046 hypothetical protein YP_310452.1 1593600 D 300269 CDS YP_310453.1 74312034 3667163 1593907..1594563 1 NC_007384.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 1594563 pdxH 3667163 pdxH Shigella sonnei Ss046 pyridoxamine 5'-phosphate oxidase YP_310453.1 1593907 D 300269 CDS YP_310454.1 74312035 3667164 1594692..1595966 1 NC_007384.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1595966 tyrS 3667164 tyrS Shigella sonnei Ss046 tyrosyl-tRNA synthetase YP_310454.1 1594692 D 300269 CDS YP_310455.1 74312036 3667165 1596025..1596888 1 NC_007384.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 1596888 pdxY 3667165 pdxY Shigella sonnei Ss046 pyridoxamine kinase YP_310455.1 1596025 D 300269 CDS YP_310456.1 74312037 3667166 complement(1597443..1598081) 1 NC_007384.1 IS4 orf 1598081 3667166 SSON_1521 Shigella sonnei Ss046 IS4 orf YP_310456.1 1597443 R 300269 CDS YP_310457.1 74312038 3667167 complement(1598200..1598787) 1 NC_007384.1 IS4 orf 1598787 3667167 SSON_1522 Shigella sonnei Ss046 IS4 orf YP_310457.1 1598200 R 300269 CDS YP_310458.1 74312039 3667169 complement(1599079..1600581) 1 NC_007384.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; tripeptide transporter permease 1600581 tppB 3667169 tppB Shigella sonnei Ss046 tripeptide transporter permease YP_310458.1 1599079 R 300269 CDS YP_310459.1 74312040 3667170 complement(1601192..1601827) 1 NC_007384.1 specific for apurinic and/or apyrimidinic sites; DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III 1601827 nth 3667170 nth Shigella sonnei Ss046 endonuclease III YP_310459.1 1601192 R 300269 CDS YP_310460.1 74312041 3667171 complement(1601827..1602522) 1 NC_007384.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex protein RsxE 1602522 ydgQ 3667171 ydgQ Shigella sonnei Ss046 electron transport complex protein RsxE YP_310460.1 1601827 R 300269 CDS YP_310461.1 74312042 3667172 complement(1602526..1603146) 1 NC_007384.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 1603146 3667172 SSON_1527 Shigella sonnei Ss046 electron transport complex protein RnfG YP_310461.1 1602526 R 300269 CDS YP_310462.1 74312043 3667173 complement(1603150..1604208) 1 NC_007384.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 1604208 rnfD 3667173 rnfD Shigella sonnei Ss046 electron transport complex protein RnfD YP_310462.1 1603150 R 300269 CDS YP_310463.1 74312044 3667312 complement(1604209..1606431) 1 NC_007384.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 1606431 3667312 SSON_1529 Shigella sonnei Ss046 electron transport complex protein RnfC YP_310463.1 1604209 R 300269 CDS YP_310464.1 74312045 3667313 complement(1606424..1607002) 1 NC_007384.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 1607002 3667313 SSON_1530 Shigella sonnei Ss046 electron transport complex protein RnfB YP_310464.1 1606424 R 300269 CDS YP_310465.1 74312046 3667314 complement(1607002..1607583) 1 NC_007384.1 Code: C; COG: COG4657; Na(+)-translocating NADH-quinone reductase subunit E 1607583 3667314 SSON_1531 Shigella sonnei Ss046 Na(+)-translocating NADH-quinone reductase subunit E YP_310465.1 1607002 R 300269 CDS YP_310466.1 74312047 3667315 complement(1607660..1608124) 1 NC_007384.1 hypothetical protein 1608124 3667315 SSON_1532 Shigella sonnei Ss046 hypothetical protein YP_310466.1 1607660 R 300269 CDS YP_310467.1 74312048 3667316 complement(1608186..1608401) 1 NC_007384.1 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein 1608401 3667316 SSON_1533 Shigella sonnei Ss046 oriC-binding nucleoid-associated protein YP_310467.1 1608186 R 300269 CDS YP_310468.2 161986531 3667317 1609035..1610075 1 NC_007384.1 Code: R; COG: COG0673; oxidoreductase 1610075 3667317 SSON_1534 Shigella sonnei Ss046 oxidoreductase YP_310468.2 1609035 D 300269 CDS YP_310469.1 74312050 3667318 complement(1610111..1611112) 1 NC_007384.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 1611112 add 3667318 add Shigella sonnei Ss046 adenosine deaminase YP_310469.1 1610111 R 300269 CDS YP_310470.1 74312051 3667319 complement(1611216..1612388) 1 NC_007384.1 Code: E; COG: COG1168; hypothetical protein 1612388 malY 3667319 malY Shigella sonnei Ss046 hypothetical protein YP_310470.1 1611216 R 300269 CDS YP_310471.1 74312052 3667320 complement(1612398..1613990) 1 NC_007384.1 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; PTS system maltose and glucose-specific transporter subunits IICB 1613990 malX 3667320 malX Shigella sonnei Ss046 PTS system maltose and glucose-specific transporter subunits IICB YP_310471.1 1612398 R 300269 CDS YP_310472.1 74312053 3667321 1614165..1615193 1 NC_007384.1 regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI 1615193 malI 3667321 malI Shigella sonnei Ss046 DNA-binding transcriptional repressor MalI YP_310472.1 1614165 D 300269 CDS YP_310473.1 74312054 3667322 1615396..1615698 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1615698 3667322 SSON_1539 Shigella sonnei Ss046 IS600 ORF1 YP_310473.1 1615396 D 300269 CDS YP_310474.1 74312055 3667323 1615839..1616552 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1616552 3667323 SSON_1540 Shigella sonnei Ss046 IS600 ORF2 YP_310474.1 1615839 D 300269 CDS YP_310475.1 74312056 3667324 1616635..1617402 1 NC_007384.1 Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase 1617402 hdhA 3667324 hdhA Shigella sonnei Ss046 7-alpha-hydroxysteroid dehydrogenase YP_310475.1 1616635 D 300269 CDS YP_310476.1 74312057 3667325 1617623..1618213 1 NC_007384.1 Code: K; COG: COG1309; repressor for uid operon 1618213 uidR 3667325 uidR Shigella sonnei Ss046 repressor for uid operon YP_310476.1 1617623 D 300269 CDS YP_310477.1 74312058 3667326 1618602..1620413 1 NC_007384.1 Code: G; COG: COG3250; beta-D-glucuronidase 1620413 uidA 3667326 uidA Shigella sonnei Ss046 beta-D-glucuronidase YP_310477.1 1618602 D 300269 CDS YP_310478.1 74312059 3667327 1620410..1621783 1 NC_007384.1 Code: G; COG: COG2211; glucuronide transporter 1621783 uidB 3667327 uidB Shigella sonnei Ss046 glucuronide transporter YP_310478.1 1620410 D 300269 CDS YP_310479.1 74312060 3667328 1621822..1623132 1 NC_007384.1 outer membrane porin protein 1623132 uidC 3667328 uidC Shigella sonnei Ss046 outer membrane porin protein YP_310479.1 1621822 D 300269 CDS YP_310480.1 74312061 3667329 complement(1623313..1624821) 1 NC_007384.1 Code: S; COG: COG5339; hypothetical protein 1624821 ydgA 3667329 ydgA Shigella sonnei Ss046 hypothetical protein YP_310480.1 1623313 R 300269 CDS YP_310481.1 74312062 3667330 complement(1624922..1626097) 1 NC_007384.1 Code: G; COG: COG1482; mannose-6-phosphate isomerase 1626097 manA 3667330 manA Shigella sonnei Ss046 mannose-6-phosphate isomerase YP_310481.1 1624922 R 300269 CDS YP_310482.1 74312063 3667331 1626296..1627942 1 NC_007384.1 fumarate hydratase Class I; aerobic isozyme; Code: C; COG: COG1951; fumarase A 1627942 fumA 3667331 fumA Shigella sonnei Ss046 fumarase A YP_310482.1 1626296 D 300269 CDS YP_310483.1 74312064 3669497 1628085..1629488 1 NC_007384.1 fumarate hydratase Class II; isozyme; class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1629488 fumC 3669497 fumC Shigella sonnei Ss046 fumarate hydratase YP_310483.1 1628085 D 300269 CDS YP_310484.1 74312065 3669498 complement(1629485..1630414) 1 NC_007384.1 inhibition of replication at Ter sites; binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 1630414 tus 3669498 tus Shigella sonnei Ss046 DNA replication terminus site-binding protein YP_310484.1 1629485 R 300269 CDS YP_310485.1 74312066 3669499 complement(1630490..1631791) 1 NC_007384.1 RstA regulator; Code: T; COG: COG0642; sensor protein RstB 1631791 rstB 3669499 rstB Shigella sonnei Ss046 sensor protein RstB YP_310485.1 1630490 R 300269 CDS YP_310486.1 74312067 3669500 complement(1631795..1632523) 1 NC_007384.1 response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 1632523 rstA 3669500 rstA Shigella sonnei Ss046 DNA-binding transcriptional regulator RstA YP_310486.1 1631795 R 300269 CDS YP_310487.1 74312068 3669501 1632643..1632978 1 NC_007384.1 Code: R; COG: COG3136; hypothetical protein 1632978 ydgC 3669501 ydgC Shigella sonnei Ss046 hypothetical protein YP_310487.1 1632643 D 300269 CDS YP_310488.1 74312069 3669502 complement(1632975..1633697) 1 NC_007384.1 Code: IQR; COG: COG1028; short chain dehydrogenase 1633697 ydgB 3669502 ydgB Shigella sonnei Ss046 short chain dehydrogenase YP_310488.1 1632975 R 300269 CDS YP_310489.1 74312070 3669503 complement(1633734..1635116) 1 NC_007384.1 Code: E; COG: COG0531; arginine/ornithine antiporter 1635116 3669503 SSON_1555 Shigella sonnei Ss046 arginine/ornithine antiporter YP_310489.1 1633734 R 300269 CDS YP_310490.1 74312071 3669504 complement(1635302..1636246) 1 NC_007384.1 hypothetical protein 1636246 ydgH 3669504 ydgH Shigella sonnei Ss046 hypothetical protein YP_310490.1 1635302 R 300269 CDS YP_310491.1 74312072 3669505 1636770..1638302 1 NC_007384.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 1638302 pntA 3669505 pntA Shigella sonnei Ss046 NAD(P) transhydrogenase subunit alpha YP_310491.1 1636770 D 300269 CDS YP_310492.1 74312073 3669506 1638313..1639701 1 NC_007384.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 1639701 pntB 3669506 pntB Shigella sonnei Ss046 pyridine nucleotide transhydrogenase YP_310492.1 1638313 D 300269 CDS YP_310493.1 74312074 3669507 complement(1639726..1640760) 1 NC_007384.1 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; transporter 1640760 tqsA 3669507 tqsA Shigella sonnei Ss046 transporter YP_310493.1 1639726 R 300269 CDS YP_310494.1 74312075 3669508 1641172..1641537 1 NC_007384.1 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ 1641537 3669508 SSON_1560 Shigella sonnei Ss046 multidrug efflux system protein MdtJ YP_310494.1 1641172 D 300269 CDS YP_310495.1 74312076 3669509 1641524..1641853 1 NC_007384.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI 1641853 3669509 SSON_1561 Shigella sonnei Ss046 multidrug efflux system protein MdtI YP_310495.1 1641524 D 300269 CDS YP_310496.1 74312077 3669510 complement(1641892..1642713) 1 NC_007384.1 Code: E; COG: COG3591; hypothetical protein 1642713 3669510 SSON_1562 Shigella sonnei Ss046 hypothetical protein YP_310496.1 1641892 R 300269 CDS YP_310497.1 74312078 3669511 complement(1642989..1643261) 1 NC_007384.1 required for growth and survival under moderately acid conditions; acid shock protein 1643261 asr 3669511 asr Shigella sonnei Ss046 acid shock protein YP_310497.1 1642989 R 300269 CDS YP_310498.1 74312079 3669512 complement(1643385..1644005) 1 NC_007384.1 Code: L; COG: COG2801; IS2 ORF2 1644005 3669512 SSON_1564 Shigella sonnei Ss046 IS2 ORF2 YP_310498.1 1643385 R 300269 CDS YP_310499.1 74312080 3669513 complement(1644067..1644864) 1 NC_007384.1 Code: L; COG: COG1484; IS21 ORF2 1644864 3669513 SSON_1565 Shigella sonnei Ss046 IS21 ORF2 YP_310499.1 1644067 R 300269 CDS YP_310500.1 74312081 3669514 complement(1644864..1646036) 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 1646036 3669514 SSON_1566 Shigella sonnei Ss046 IS21 ORF1 YP_310500.1 1644864 R 300269 CDS YP_310501.1 74312082 3669515 complement(1646123..1646425) 1 NC_007384.1 IS2 ORF2 1646425 3669515 SSON_1567 Shigella sonnei Ss046 IS2 ORF2 YP_310501.1 1646123 R 300269 CDS YP_310502.1 74312083 3669458 complement(1647191..1648444) 1 NC_007384.1 Code: GEPR; COG: COG0477; transporter 1648444 ynfM 3669458 ynfM Shigella sonnei Ss046 transporter YP_310502.1 1647191 R 300269 CDS YP_310503.1 74312084 3669459 1648551..1649444 1 NC_007384.1 Code: K; COG: COG0583; LysR family transcriptional regulator 1649444 ynfL 3669459 ynfL Shigella sonnei Ss046 LysR family transcriptional regulator YP_310503.1 1648551 D 300269 CDS YP_310504.1 74312085 3669460 1649579..1650799 1 NC_007384.1 Code: KG; COG: COG1940; NAGC-like transcriptional regulator 1650799 mlc 3669460 mlc Shigella sonnei Ss046 NAGC-like transcriptional regulator YP_310504.1 1649579 D 300269 CDS YP_310505.2 161986530 3669461 1650924..1651619 1 NC_007384.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 1651619 3669461 SSON_1571 Shigella sonnei Ss046 dithiobiotin synthetase YP_310505.2 1650924 D 300269 CDS YP_310506.2 161986529 3669462 complement(1651572..1652828) 1 NC_007384.1 Code: P; COG: COG0038; voltage-gated ClC-type chloride channel ClcB 1652828 3669462 SSON_1572 Shigella sonnei Ss046 voltage-gated ClC-type chloride channel ClcB YP_310506.2 1651572 R 300269 CDS YP_310507.2 161986528 3669463 complement(1653023..1653637) 1 NC_007384.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1653637 3669463 SSON_1573 Shigella sonnei Ss046 twin-argninine leader-binding protein DmsD YP_310507.2 1653023 R 300269 CDS YP_310508.1 74312089 3669464 complement(1653680..1654534) 1 NC_007384.1 Code: R; COG: COG3302; DMSO reductase anchor subunit 1654534 3669464 SSON_1574 Shigella sonnei Ss046 DMSO reductase anchor subunit YP_310508.1 1653680 R 300269 CDS YP_310509.1 74312090 3669465 complement(1654536..1655153) 1 NC_007384.1 Code: C; COG: COG0437; oxidoreductase, Fe-S subunit 1655153 3669465 SSON_1575 Shigella sonnei Ss046 oxidoreductase, Fe-S subunit YP_310509.1 1654536 R 300269 CDS YP_310510.1 74312091 3669467 1656492..1656995 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1656995 3669467 SSON_1577 Shigella sonnei Ss046 IS1 ORF YP_310510.1 1656492 D 300269 CDS YP_310511.1 74312092 3669468 complement(1657520..1657726) 1 NC_007384.1 prophage protein 1657726 3669468 SSON_1578 Shigella sonnei Ss046 prophage protein YP_310511.1 1657520 R 300269 CDS YP_310512.1 74312093 3669469 1659328..1659753 1 NC_007384.1 hypothetical protein 1659753 3669469 SSON_1579 Shigella sonnei Ss046 hypothetical protein YP_310512.1 1659328 D 300269 CDS YP_310513.1 74312094 3669470 1659825..1660889 1 NC_007384.1 prophage protein 1660889 3669470 SSON_1580 Shigella sonnei Ss046 prophage protein YP_310513.1 1659825 D 300269 CDS YP_310514.1 74312095 3669471 1660896..1661642 1 NC_007384.1 encoded within cryptic prophage; Code: L; COG: COG1484; replication protein 1661642 3669471 SSON_1581 Shigella sonnei Ss046 replication protein YP_310514.1 1660896 D 300269 CDS YP_310515.1 74312096 3669472 1661664..1662389 1 NC_007384.1 prophage protein 1662389 3669472 SSON_1582 Shigella sonnei Ss046 prophage protein YP_310515.1 1661664 D 300269 CDS YP_310516.1 74312097 3669473 1663456..1665288 1 NC_007384.1 methylase 1665288 3669473 SSON_1583 Shigella sonnei Ss046 methylase YP_310516.1 1663456 D 300269 CDS YP_310517.1 74312098 3669474 1665285..1666367 1 NC_007384.1 restriction endonuclease 1666367 3669474 SSON_1584 Shigella sonnei Ss046 restriction endonuclease YP_310517.1 1665285 D 300269 CDS YP_310518.1 74312099 3669475 1666769..1667272 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1667272 3669475 SSON_1585 Shigella sonnei Ss046 IS1 ORF YP_310518.1 1666769 D 300269 CDS YP_310519.1 74312100 3669476 1667336..1668796 1 NC_007384.1 Code: G; COG: COG0246; oxidoreductase 1668796 ydfI 3669476 ydfI Shigella sonnei Ss046 oxidoreductase YP_310519.1 1667336 D 300269 CDS YP_310520.1 74312101 3669477 complement(1668832..1669035) 1 NC_007384.1 hypothetical protein 1669035 3669477 SSON_1587 Shigella sonnei Ss046 hypothetical protein YP_310520.1 1668832 R 300269 CDS YP_310521.1 74312102 3669478 complement(1669212..1669898) 1 NC_007384.1 Code: K; COG: COG1802; hypothetical protein 1669898 ydfH 3669478 ydfH Shigella sonnei Ss046 hypothetical protein YP_310521.1 1669212 R 300269 CDS YP_310522.1 74312103 3669479 complement(1669987..1670733) 1 NC_007384.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase 1670733 ydfG 3669479 ydfG Shigella sonnei Ss046 3-hydroxy acid dehydrogenase YP_310522.1 1669987 R 300269 CDS YP_310523.1 74312104 3669480 1670870..1672915 1 NC_007384.1 Code: E; COG: COG0339; dipeptidyl carboxypeptidase II 1672915 dcp 3669480 dcp Shigella sonnei Ss046 dipeptidyl carboxypeptidase II YP_310523.1 1670870 D 300269 CDS YP_310524.1 74312105 3669481 complement(1672960..1673478) 1 NC_007384.1 Code: R; COG: COG1546; competence damage-inducible protein A 1673478 ydeJ 3669481 ydeJ Shigella sonnei Ss046 competence damage-inducible protein A YP_310524.1 1672960 R 300269 CDS YP_310525.1 74312106 3669482 1673754..1674146 1 NC_007384.1 Code: S; COG: COG3111; hypothetical protein 1674146 ydeI 3669482 ydeI Shigella sonnei Ss046 hypothetical protein YP_310525.1 1673754 D 300269 CDS YP_310526.1 74312107 3669483 1674401..1675291 1 NC_007384.1 Code: T; COG: COG2199; hypothetical protein 1675291 ydeH 3669483 ydeH Shigella sonnei Ss046 hypothetical protein YP_310526.1 1674401 D 300269 CDS YP_310527.1 74312108 3669484 1675759..1676262 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1676262 3669484 SSON_1594 Shigella sonnei Ss046 IS1 ORF YP_310527.1 1675759 D 300269 CDS YP_310528.1 74312109 3669485 1676323..1677762 1 NC_007384.1 converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase 1677762 celA 3669485 celA Shigella sonnei Ss046 6-phospho-beta-glucosidase YP_310528.1 1676323 D 300269 CDS YP_310529.1 74312110 3669486 complement(1677819..1678037) 1 NC_007384.1 hypothetical protein 1678037 marB 3669486 marB Shigella sonnei Ss046 hypothetical protein YP_310529.1 1677819 R 300269 CDS YP_310530.2 161986527 3669487 complement(1678069..1678452) 1 NC_007384.1 multiple antibiotic resistance; transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; DNA-binding transcriptional activator MarA 1678452 marA 3669487 marA Shigella sonnei Ss046 DNA-binding transcriptional activator MarA YP_310530.2 1678069 R 300269 CDS YP_310531.2 161986526 3669488 complement(1678472..1678906) 1 NC_007384.1 repressor of mar operon; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; DNA-binding transcriptional repressor MarR 1678906 marR 3669488 marR Shigella sonnei Ss046 DNA-binding transcriptional repressor MarR YP_310531.2 1678472 R 300269 CDS YP_310532.1 74312113 3669489 1679118..1679783 1 NC_007384.1 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC 1679783 ydeB 3669489 ydeB Shigella sonnei Ss046 multiple drug resistance protein MarC YP_310532.1 1679118 D 300269 CDS YP_310533.1 74312114 3669490 complement(1679808..1680998) 1 NC_007384.1 Code: G; COG: COG2814; sugar efflux transporter 1680998 ydeA 3669490 ydeA Shigella sonnei Ss046 sugar efflux transporter YP_310533.1 1679808 R 300269 CDS YP_310534.1 74312115 3669491 complement(1681148..1682263) 1 NC_007384.1 hypothetical protein 1682263 3669491 SSON_1601 Shigella sonnei Ss046 hypothetical protein YP_310534.1 1681148 R 300269 CDS YP_310535.1 74312116 3669492 complement(1682340..1683221) 1 NC_007384.1 Code: K; COG: COG0583; LysR family transcriptional regulator 1683221 yneJ 3669492 yneJ Shigella sonnei Ss046 LysR family transcriptional regulator YP_310535.1 1682340 R 300269 CDS YP_310536.1 74312117 3669493 1683298..1684710 1 NC_007384.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; succinate semialdehyde dehydrogenase 1684710 3669493 SSON_1603 Shigella sonnei Ss046 succinate semialdehyde dehydrogenase YP_310536.1 1683298 D 300269 CDS YP_310537.1 74312118 3669494 1684774..1685700 1 NC_007384.1 catalyzes the formation of glutamate from glutamine; glutaminase 1685700 yneH 3669494 yneH Shigella sonnei Ss046 glutaminase YP_310537.1 1684774 D 300269 CDS YP_310538.1 74312119 3669495 complement(1685874..1686377) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1686377 3669495 SSON_1605 Shigella sonnei Ss046 IS1 ORF YP_310538.1 1685874 R 300269 CDS YP_310539.1 74312120 3669496 1687446..1687925 1 NC_007384.1 Code: T; COG: COG2199; hypothetical protein 1687925 3669496 SSON_1606 Shigella sonnei Ss046 hypothetical protein YP_310539.1 1687446 D 300269 CDS YP_310540.1 74312121 3666481 1688152..1689600 1 NC_007384.1 catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase 1689600 uxaB 3666481 uxaB Shigella sonnei Ss046 altronate oxidoreductase YP_310540.1 1688152 D 300269 CDS YP_310541.1 74312122 3666484 1691928..1692431 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1692431 3666484 SSON_1610 Shigella sonnei Ss046 IS1 ORF YP_310541.1 1691928 D 300269 CDS YP_310542.1 74312123 3666485 1692654..1694867 1 NC_007384.1 hypothetical protein 1694867 ydeK 3666485 ydeK Shigella sonnei Ss046 hypothetical protein YP_310542.1 1692654 D 300269 CDS YP_310543.1 74312124 3666486 1695132..1696163 1 NC_007384.1 Code: L; COG: COG3335; IS630 orf 1696163 3666486 SSON_1612 Shigella sonnei Ss046 IS630 orf YP_310543.1 1695132 D 300269 CDS YP_310544.1 74312125 3666487 1696565..1696831 1 NC_007384.1 regulatory protein; Code: K; COG: COG1396; DNA-binding transcriptional regulator HipB 1696831 hipB 3666487 hipB Shigella sonnei Ss046 DNA-binding transcriptional regulator HipB YP_310544.1 1696565 D 300269 CDS YP_310545.1 74312126 3666489 complement(1698607..1699227) 1 NC_007384.1 Code: L; COG: COG2801; IS2 ORF2 1699227 3666489 SSON_1615 Shigella sonnei Ss046 IS2 ORF2 YP_310545.1 1698607 R 300269 CDS YP_310546.1 74312127 3666490 1699255..1699461 1 NC_007384.1 IS600 ORF2 1699461 3666490 SSON_1616 Shigella sonnei Ss046 IS600 ORF2 YP_310546.1 1699255 D 300269 CDS YP_310547.1 74312128 3666491 1699470..1699694 1 NC_007384.1 IS600 ORF2 1699694 3666491 SSON_1617 Shigella sonnei Ss046 IS600 ORF2 YP_310547.1 1699470 D 300269 CDS YP_310548.1 74312129 3666492 1699926..1700405 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 1700405 3666492 SSON_1618 Shigella sonnei Ss046 IS21 ORF1 YP_310548.1 1699926 D 300269 CDS YP_310549.1 74312130 3666493 1700405..1701202 1 NC_007384.1 Code: L; COG: COG1484; IS21 ORF2 1701202 3666493 SSON_1619 Shigella sonnei Ss046 IS21 ORF2 YP_310549.1 1700405 D 300269 CDS YP_310550.1 74312131 3666494 1701250..1701519 1 NC_007384.1 IS2 ORF2 1701519 3666494 SSON_1620 Shigella sonnei Ss046 IS2 ORF2 YP_310550.1 1701250 D 300269 CDS YP_310551.1 74312132 3666495 1701790..1702704 1 NC_007384.1 similar to FimH protein; adhesin 1702704 3666495 SSON_1621 Shigella sonnei Ss046 adhesin YP_310551.1 1701790 D 300269 CDS YP_310552.1 74312133 3666496 1703038..1705317 1 NC_007384.1 in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase family; oxidoreductase 1705317 3666496 SSON_1622 Shigella sonnei Ss046 oxidoreductase YP_310552.1 1703038 D 300269 CDS YP_310553.1 74312134 3666497 1705565..1705762 1 NC_007384.1 hypothetical protein 1705762 3666497 SSON_1623 Shigella sonnei Ss046 hypothetical protein YP_310553.1 1705565 D 300269 CDS YP_310554.1 74312135 3666498 1705837..1706598 1 NC_007384.1 regulates the cellular response to acid resistance; transcriptional regulator YdeO 1706598 3666498 SSON_1624 Shigella sonnei Ss046 transcriptional regulator YdeO YP_310554.1 1705837 D 300269 CDS YP_310555.1 74312136 3666499 1706999..1708681 1 NC_007384.1 Code: P; COG: COG3119; sulfatase 1708681 3666499 SSON_1625 Shigella sonnei Ss046 sulfatase YP_310555.1 1706999 D 300269 CDS YP_310556.1 74312137 3666500 1708718..1709890 1 NC_007384.1 Code: R; COG: COG0641; hypothetical protein 1709890 3666500 SSON_1626 Shigella sonnei Ss046 hypothetical protein YP_310556.1 1708718 D 300269 CDS YP_310557.1 74312138 3668656 1710187..1711872 1 NC_007384.1 Code: R; COG: COG4178; ABC transporter ATP-binding protein 1711872 yddA 3668656 yddA Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_310557.1 1710187 D 300269 CDS YP_310558.1 74312139 3668657 complement(1711913..1713259) 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 1713259 3668657 SSON_1628 Shigella sonnei Ss046 IS4 orf YP_310558.1 1711913 R 300269 CDS YP_310559.1 74312140 3668658 1713349..1715721 1 NC_007384.1 hypothetical protein 1715721 yddB 3668658 yddB Shigella sonnei Ss046 hypothetical protein YP_310559.1 1713349 D 300269 CDS YP_310560.1 74312141 3668659 1715766..1718561 1 NC_007384.1 Code: R; COG: COG0612; peptidase 1718561 pqqL 3668659 pqqL Shigella sonnei Ss046 peptidase YP_310560.1 1715766 D 300269 CDS YP_310561.1 74312142 3668660 1718923..1720323 1 NC_007384.1 Code: E; COG: COG0076; glutamate decarboxylase 1720323 gadB 3668660 gadB Shigella sonnei Ss046 glutamate decarboxylase YP_310561.1 1718923 D 300269 CDS YP_310562.1 74312143 3668661 1720479..1722014 1 NC_007384.1 transporter; Code: E; COG: COG0531; acid sensitivity protein 1722014 xasA 3668661 xasA Shigella sonnei Ss046 acid sensitivity protein YP_310562.1 1720479 D 300269 CDS YP_310563.1 74312144 3668662 1722145..1723464 1 NC_007384.1 Code: S; COG: COG1649; hypothetical protein 1723464 3668662 SSON_1633 Shigella sonnei Ss046 hypothetical protein YP_310563.1 1722145 D 300269 CDS YP_310564.1 74312145 3668663 1723836..1725218 1 NC_007384.1 Code: T; COG: COG2199; hypothetical protein 1725218 3668663 SSON_1634 Shigella sonnei Ss046 hypothetical protein YP_310564.1 1723836 D 300269 CDS YP_310565.1 74312146 3668664 1725219..1727642 1 NC_007384.1 heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate; cAMP phosphodiesterase 1727642 3668664 SSON_1635 Shigella sonnei Ss046 cAMP phosphodiesterase YP_310565.1 1725219 D 300269 CDS YP_310566.1 74312147 3668665 1727901..1728482 1 NC_007384.1 catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis; D-alanyl-D-alanine dipeptidase 1728482 3668665 SSON_1636 Shigella sonnei Ss046 D-alanyl-D-alanine dipeptidase YP_310566.1 1727901 D 300269 CDS YP_310567.1 74312148 3668666 1728496..1730046 1 NC_007384.1 Code: E; COG: COG0747; hemin-binding lipoprotein 1730046 3668666 SSON_1637 Shigella sonnei Ss046 hemin-binding lipoprotein YP_310567.1 1728496 D 300269 CDS YP_310568.1 74312149 3668667 1730048..1731070 1 NC_007384.1 Code: EP; COG: COG0601; transport system permease 1731070 3668667 SSON_1638 Shigella sonnei Ss046 transport system permease YP_310568.1 1730048 D 300269 CDS YP_310569.1 74312150 3668668 1731067..1731963 1 NC_007384.1 Code: EP; COG: COG1173; ATP-dependent peptide transporter membrane subunit 1731963 3668668 SSON_1639 Shigella sonnei Ss046 ATP-dependent peptide transporter membrane subunit YP_310569.1 1731067 D 300269 CDS YP_310570.1 74312151 3668669 1731960..1732946 1 NC_007384.1 Code: EP; COG: COG0444; ABC transporter ATP-binding protein 1732946 3668669 SSON_1640 Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_310570.1 1731960 D 300269 CDS YP_310571.1 74312152 3668670 1733125..1733865 1 NC_007384.1 Code: EP; COG: COG1124; ABC transporter ATP-binding protein 1733865 3668670 SSON_1641 Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_310571.1 1733125 D 300269 CDS YP_310572.1 74312153 3668671 complement(1733921..1734352) 1 NC_007384.1 Code: O; COG: COG1764; osmotically inducible protein 1734352 osmC 3668671 osmC Shigella sonnei Ss046 osmotically inducible protein YP_310572.1 1733921 R 300269 CDS YP_310573.1 74312154 3668672 1734975..1735478 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1735478 3668672 SSON_1643 Shigella sonnei Ss046 IS1 ORF YP_310573.1 1734975 D 300269 CDS YP_310574.1 74312155 3668673 1735790..1735927 1 NC_007384.1 protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase; 30S ribosomal subunit S22 1735927 rpsV 3668673 rpsV Shigella sonnei Ss046 30S ribosomal subunit S22 YP_310574.1 1735790 D 300269 CDS YP_310575.2 228861782 3668674 1736084..1737781 1 NC_007384.1 malic enzyme; malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 1737781 sfcA 3668674 sfcA Shigella sonnei Ss046 malate dehydrogenase YP_310575.2 1736084 D 300269 CDS YP_310576.1 74312157 3666987 1738985..1739347 1 NC_007384.1 Code: R; COG: COG3093; hypothetical protein 1739347 yddM 3666987 yddM Shigella sonnei Ss046 hypothetical protein YP_310576.1 1738985 D 300269 CDS YP_310577.1 74312158 3666988 complement(1739575..1740228) 1 NC_007384.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma 1740228 fdnI 3666988 fdnI Shigella sonnei Ss046 formate dehydrogenase-N subunit gamma YP_310577.1 1739575 R 300269 CDS YP_310578.1 74312159 3666989 complement(1740221..1741105) 1 NC_007384.1 Code: C; COG: COG0437; formate dehydrogenase-N, nitrate-inducible, iron-sulfur subunit beta 1741105 fdnH 3666989 fdnH Shigella sonnei Ss046 formate dehydrogenase-N, nitrate-inducible, iron-sulfur subunit beta YP_310578.1 1740221 R 300269 CDS YP_310579.1 74312160 3666990 complement(1741118..1744165) 1 NC_007384.1 Code: C; COG: COG0243; formate dehydrogenase-N, nitrate-inducible subunit alpha 1744165 fdnG 3666990 fdnG Shigella sonnei Ss046 formate dehydrogenase-N, nitrate-inducible subunit alpha YP_310579.1 1741118 R 300269 CDS YP_310580.1 74312161 3666991 1744397..1745278 1 NC_007384.1 Code: GER; COG: COG0697; hypothetical protein 1745278 yddG 3666991 yddG Shigella sonnei Ss046 hypothetical protein YP_310580.1 1744397 D 300269 CDS YP_310581.1 74312162 3666992 1745537..1746637 1 NC_007384.1 Code: M; COG: COG3203; outer membrane porin protein 1746637 3666992 SSON_1652 Shigella sonnei Ss046 outer membrane porin protein YP_310581.1 1745537 D 300269 CDS YP_310582.1 74312163 3666993 1746807..1747970 1 NC_007384.1 Code: S; COG: COG4886; hypothetical protein 1747970 3666993 SSON_1653 Shigella sonnei Ss046 hypothetical protein YP_310582.1 1746807 D 300269 CDS YP_310583.1 74312164 3666994 1748054..1749085 1 NC_007384.1 Code: L; COG: COG3335; IS630 orf 1749085 3666994 SSON_1654 Shigella sonnei Ss046 IS630 orf YP_310583.1 1748054 D 300269 CDS YP_310584.2 161986525 3666995 complement(1750386..1751291) 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1751291 3666995 SSON_1655 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_310584.2 1750386 R 300269 CDS YP_310585.1 74312166 3666996 1751571..1752932 1 NC_007384.1 Code: P; COG: COG2223; nitrite extrusion protein 2 1752932 narU 3666996 narU Shigella sonnei Ss046 nitrite extrusion protein 2 YP_310585.1 1751571 D 300269 CDS YP_310586.1 74312167 3666997 1753014..1756754 1 NC_007384.1 Code: C; COG: COG5013; cryptic nitrate reductase 2 subunit alpha 1756754 narZ 3666997 narZ Shigella sonnei Ss046 cryptic nitrate reductase 2 subunit alpha YP_310586.1 1753014 D 300269 CDS YP_310587.1 74312168 3666998 1756751..1758295 1 NC_007384.1 Code: C; COG: COG1140; cryptic nitrate reductase 2 subunit beta 1758295 narY 3666998 narY Shigella sonnei Ss046 cryptic nitrate reductase 2 subunit beta YP_310587.1 1756751 D 300269 CDS YP_310588.1 74312169 3666999 1758295..1758990 1 NC_007384.1 Code: C; COG: COG2180; cryptic nitrate reductase 2 subunit delta, assembly function 1758990 narW 3666999 narW Shigella sonnei Ss046 cryptic nitrate reductase 2 subunit delta, assembly function YP_310588.1 1758295 D 300269 CDS YP_310589.1 74312170 3667000 1758987..1759667 1 NC_007384.1 Code: C; COG: COG2181; cryptic nitrate reductase 2 subunit gamma 1759667 narV 3667000 narV Shigella sonnei Ss046 cryptic nitrate reductase 2 subunit gamma YP_310589.1 1758987 D 300269 CDS YP_310590.1 74312171 3667001 1759746..1760639 1 NC_007384.1 Code: R; COG: COG0384; hypothetical protein 1760639 yddE 3667001 yddE Shigella sonnei Ss046 hypothetical protein YP_310590.1 1759746 D 300269 CDS YP_310591.1 74312172 3667002 complement(1760735..1761580) 1 NC_007384.1 Code: Q; COG: COG2162; N-hydroxyarylamine O-acetyltransferase 1761580 3667002 SSON_1662 Shigella sonnei Ss046 N-hydroxyarylamine O-acetyltransferase YP_310591.1 1760735 R 300269 CDS YP_310592.1 74312173 3667003 1761705..1762322 1 NC_007384.1 Code: R; COG: COG1853; hypothetical protein 1762322 3667003 SSON_1663 Shigella sonnei Ss046 hypothetical protein YP_310592.1 1761705 D 300269 CDS YP_310593.1 74312174 3667004 complement(1762326..1762553) 1 NC_007384.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 1762553 ydcE 3667004 ydcE Shigella sonnei Ss046 4-oxalocrotonate tautomerase YP_310593.1 1762326 R 300269 CDS YP_310594.1 74312175 3667005 complement(1762653..1763387) 1 NC_007384.1 Code: L; COG: COG5433; hypothetical protein 1763387 3667005 SSON_1665 Shigella sonnei Ss046 hypothetical protein YP_310594.1 1762653 R 300269 CDS YP_310595.1 74312176 3666746 complement(1763375..1763725) 1 NC_007384.1 hypothetical protein 1763725 3666746 SSON_1666 Shigella sonnei Ss046 hypothetical protein YP_310595.1 1763375 R 300269 CDS YP_310596.1 74312177 3666747 complement(1763928..1765064) 1 NC_007384.1 Code: L; COG: COG5433; receptor 1765064 ydcC 3666747 ydcC Shigella sonnei Ss046 receptor YP_310596.1 1763928 R 300269 CDS YP_310597.1 74312178 3666748 complement(1765645..1766148) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1766148 3666748 SSON_1668 Shigella sonnei Ss046 IS1 ORF YP_310597.1 1765645 R 300269 CDS YP_310598.1 74312179 3666749 complement(1767079..1767834) 1 NC_007384.1 Code: L; COG: COG1484; transposase subunit 1767834 3666749 SSON_1669 Shigella sonnei Ss046 transposase subunit YP_310598.1 1767079 R 300269 CDS YP_310599.1 74312180 3666750 complement(1767851..1769386) 1 NC_007384.1 Code: L; COG: COG4584; transposase 1769386 3666750 SSON_1670 Shigella sonnei Ss046 transposase YP_310599.1 1767851 R 300269 CDS YP_310600.1 74312181 3666751 1769582..1769866 1 NC_007384.1 ISSfl2 ORF 1769866 3666751 SSON_1671 Shigella sonnei Ss046 ISSfl2 ORF YP_310600.1 1769582 D 300269 CDS YP_310601.1 74312182 3666752 1770045..1770461 1 NC_007384.1 ISSfl2 ORF 1770461 3666752 SSON_1672 Shigella sonnei Ss046 ISSfl2 ORF YP_310601.1 1770045 D 300269 CDS YP_310602.1 74312183 3666753 complement(1771082..1774885) 1 NC_007384.1 Code: M; COG: COG3209; rhs core protein with extension 1774885 3666753 SSON_1673 Shigella sonnei Ss046 rhs core protein with extension YP_310602.1 1771082 R 300269 CDS YP_310603.1 74312184 3666754 complement(1775143..1776138) 1 NC_007384.1 conserved protein; receptor; Code: L; COG: COG5433; H repeat-containing protein 1776138 3666754 SSON_1674 Shigella sonnei Ss046 H repeat-containing protein YP_310603.1 1775143 R 300269 CDS YP_310604.1 74312185 3666755 complement(1776639..1779908) 1 NC_007384.1 Code: M; COG: COG3209; rhs core protein with extension 1779908 3666755 SSON_1675 Shigella sonnei Ss046 rhs core protein with extension YP_310604.1 1776639 R 300269 CDS YP_310605.1 74312186 3666756 complement(1780131..1780601) 1 NC_007384.1 Rhs element protein 1780601 3666756 SSON_1676 Shigella sonnei Ss046 Rhs element protein YP_310605.1 1780131 R 300269 CDS YP_310606.1 74312187 3666757 complement(1780702..1782810) 1 NC_007384.1 Code: S; COG: COG3501; Rhs element protein 1782810 vgrE 3666757 vgrE Shigella sonnei Ss046 Rhs element protein YP_310606.1 1780702 R 300269 CDS YP_310607.1 74312188 3666758 complement(1783631..1783843) 1 NC_007384.1 hypothetical protein 1783843 3666758 SSON_1678 Shigella sonnei Ss046 hypothetical protein YP_310607.1 1783631 R 300269 CDS YP_310608.1 74312189 3666759 complement(1783919..1784536) 1 NC_007384.1 Code: O; COG: COG0625; transferase 1784536 3666759 SSON_1679 Shigella sonnei Ss046 transferase YP_310608.1 1783919 R 300269 CDS YP_310609.1 74312190 3666760 1784752..1786302 1 NC_007384.1 Code: E; COG: COG1113; L-asparagine permease 1786302 ansP 3666760 ansP Shigella sonnei Ss046 L-asparagine permease YP_310609.1 1784752 D 300269 CDS YP_310610.1 74312191 3666761 complement(1786417..1787478) 1 NC_007384.1 Code: S; COG: COG3391; receptor 1787478 3666761 SSON_1681 Shigella sonnei Ss046 receptor YP_310610.1 1786417 R 300269 CDS YP_310611.1 74312192 3666762 1787720..1789822 1 NC_007384.1 Code: P; COG: COG1629; outer membrane receptor for iron transport 1789822 3666762 SSON_1682 Shigella sonnei Ss046 outer membrane receptor for iron transport YP_310611.1 1787720 D 300269 CDS YP_310612.1 74312193 3666763 1790282..1790584 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1790584 3666763 SSON_1683 Shigella sonnei Ss046 IS600 ORF1 YP_310612.1 1790282 D 300269 CDS YP_310613.1 74312194 3666764 1790725..1791438 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1791438 3666764 SSON_1684 Shigella sonnei Ss046 IS600 ORF2 YP_310613.1 1790725 D 300269 CDS YP_310614.1 74312195 3668560 1792585..1792830 1 NC_007384.1 IS1 ORF 1792830 3668560 SSON_1686 Shigella sonnei Ss046 IS1 ORF YP_310614.1 1792585 D 300269 CDS YP_310615.1 74312196 3668561 complement(1792765..1793895) 1 NC_007384.1 Code: R; COG: COG2130; oxidoreductase 1793895 yncB 3668561 yncB Shigella sonnei Ss046 oxidoreductase YP_310615.1 1792765 R 300269 CDS YP_310616.1 74312197 3668562 1793983..1794501 1 NC_007384.1 Code: M; COG: COG1247; resistance protein 1794501 yncA 3668562 yncA Shigella sonnei Ss046 resistance protein YP_310616.1 1793983 D 300269 CDS YP_310617.1 74312198 3668563 1794498..1794947 1 NC_007384.1 Code: S; COG: COG3238; hypothetical protein 1794947 3668563 SSON_1689 Shigella sonnei Ss046 hypothetical protein YP_310617.1 1794498 D 300269 CDS YP_310618.1 74312199 3668564 complement(1794948..1795181) 1 NC_007384.1 hypothetical protein 1795181 3668564 SSON_1690 Shigella sonnei Ss046 hypothetical protein YP_310618.1 1794948 R 300269 CDS YP_310619.1 74312200 3668565 complement(1795267..1795515) 1 NC_007384.1 hypothetical protein 1795515 3668565 SSON_1691 Shigella sonnei Ss046 hypothetical protein YP_310619.1 1795267 R 300269 CDS YP_310620.1 74312201 3668566 complement(1795748..1796251) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1796251 3668566 SSON_1692 Shigella sonnei Ss046 IS1 ORF YP_310620.1 1795748 R 300269 CDS YP_310621.1 74312202 3668567 complement(1796813..1798237) 1 NC_007384.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 1798237 3668567 SSON_1693 Shigella sonnei Ss046 gamma-aminobutyraldehyde dehydrogenase YP_310621.1 1796813 R 300269 CDS YP_310622.1 74312203 3668568 complement(1798259..1799053) 1 NC_007384.1 Code: E; COG: COG1177; transport system permease 1799053 3668568 SSON_1694 Shigella sonnei Ss046 transport system permease YP_310622.1 1798259 R 300269 CDS YP_310623.1 74312204 3668570 complement(1799944..1800957) 1 NC_007384.1 Code: E; COG: COG3842; ABC transporter ATP-binding protein 1800957 3668570 SSON_1696 Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_310623.1 1799944 R 300269 CDS YP_310624.1 74312205 3668571 complement(1800975..1802120) 1 NC_007384.1 Code: E; COG: COG0687; transporter 1802120 3668571 SSON_1697 Shigella sonnei Ss046 transporter YP_310624.1 1800975 R 300269 CDS YP_310625.1 74312206 3668572 complement(1802365..1803771) 1 NC_007384.1 Code: KE; COG: COG1167; multifunctional transcriptional regulator/ABC transporter ATP-binding protein 1803771 3668572 SSON_1698 Shigella sonnei Ss046 multifunctional transcriptional regulator/ABC transporter ATP-binding protein YP_310625.1 1802365 R 300269 CDS YP_310626.1 74312207 3668573 complement(1803850..1804287) 1 NC_007384.1 Code: S; COG: COG1598; hypothetical protein 1804287 3668573 SSON_1699 Shigella sonnei Ss046 hypothetical protein YP_310626.1 1803850 R 300269 CDS YP_310627.1 74312208 3668574 1804699..1805001 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1805001 3668574 SSON_1700 Shigella sonnei Ss046 IS600 ORF1 YP_310627.1 1804699 D 300269 CDS YP_310628.1 74312209 3668575 1805142..1805855 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1805855 3668575 SSON_1701 Shigella sonnei Ss046 IS600 ORF2 YP_310628.1 1805142 D 300269 CDS YP_310629.1 74312210 3668576 1805955..1806185 1 NC_007384.1 hypothetical protein 1806185 3668576 SSON_1702 Shigella sonnei Ss046 hypothetical protein YP_310629.1 1805955 D 300269 CDS YP_310630.1 74312211 3668577 complement(1806277..1808280) 1 NC_007384.1 Code: O; COG: COG0826; collagenase 1808280 ydcP 3668577 ydcP Shigella sonnei Ss046 collagenase YP_310630.1 1806277 R 300269 CDS YP_310631.1 74312212 3668578 complement(1808311..1808847) 1 NC_007384.1 Code: K; COG: COG1396; hypothetical protein 1808847 ydcN 3668578 ydcN Shigella sonnei Ss046 hypothetical protein YP_310631.1 1808311 R 300269 CDS YP_310632.1 74312213 3668354 complement(1809899..1810717) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1810717 3668354 SSON_1706 Shigella sonnei Ss046 IS600 ORF2 YP_310632.1 1809899 R 300269 CDS YP_310633.1 74312214 3668355 1810985..1811488 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1811488 3668355 SSON_1707 Shigella sonnei Ss046 IS1 ORF YP_310633.1 1810985 D 300269 CDS YP_310634.1 74312215 3668356 complement(1811530..1811832) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1811832 3668356 SSON_1708 Shigella sonnei Ss046 IS600 ORF1 YP_310634.1 1811530 R 300269 CDS YP_310635.1 74312216 3668357 complement(1812186..1813394) 1 NC_007384.1 Code: L; COG: COG0675; virulence protein 1813394 3668357 SSON_1709 Shigella sonnei Ss046 virulence protein YP_310635.1 1812186 R 300269 CDS YP_310636.1 74312217 3668359 complement(1814623..1815126) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1815126 3668359 SSON_1711 Shigella sonnei Ss046 IS1 ORF YP_310636.1 1814623 R 300269 CDS YP_310637.1 74312218 3668360 complement(1815669..1816262) 1 NC_007384.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 1816262 tehB 3668360 tehB Shigella sonnei Ss046 tellurite resistance protein TehB YP_310637.1 1815669 R 300269 CDS YP_310638.1 74312219 3668361 complement(1816259..1817251) 1 NC_007384.1 Code: P; COG: COG1275; potassium-tellurite ethidium and proflavin transporter 1817251 tehA 3668361 tehA Shigella sonnei Ss046 potassium-tellurite ethidium and proflavin transporter YP_310638.1 1816259 R 300269 CDS YP_310639.1 74312220 3668362 1817375..1818355 1 NC_007384.1 hypothetical protein 1818355 3668362 SSON_1714 Shigella sonnei Ss046 hypothetical protein YP_310639.1 1817375 D 300269 CDS YP_310640.1 74312221 3668363 complement(1818350..1818886) 1 NC_007384.1 Code: J; COG: COG1670; ribosomal-protein-L7/L12-serine acetyltransferase 1818886 rimL 3668363 rimL Shigella sonnei Ss046 ribosomal-protein-L7/L12-serine acetyltransferase YP_310640.1 1818350 R 300269 CDS YP_310641.1 74312222 3668364 complement(1818949..1819116) 1 NC_007384.1 Code: S; COG: COG2841; hypothetical protein 1819116 ydcH 3668364 ydcH Shigella sonnei Ss046 hypothetical protein YP_310641.1 1818949 R 300269 CDS YP_310642.1 74312223 3668365 1819189..1819392 1 NC_007384.1 hypothetical protein 1819392 3668365 SSON_1717 Shigella sonnei Ss046 hypothetical protein YP_310642.1 1819189 D 300269 CDS YP_310643.1 74312224 3668366 complement(1819313..1820968) 1 NC_007384.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 1820968 mdoD 3668366 mdoD Shigella sonnei Ss046 glucan biosynthesis protein D YP_310643.1 1819313 R 300269 CDS YP_310644.1 74312225 3668367 complement(1821193..1822536) 1 NC_007384.1 Code: S; COG: COG5383; hypothetical protein 1822536 3668367 SSON_1719 Shigella sonnei Ss046 hypothetical protein YP_310644.1 1821193 R 300269 CDS YP_310645.1 74312226 3668368 1822612..1823676 1 NC_007384.1 Code: K; COG: COG0583; LysR family transcriptional regulator 1823676 3668368 SSON_1720 Shigella sonnei Ss046 LysR family transcriptional regulator YP_310645.1 1822612 D 300269 CDS YP_310646.1 74312227 3668369 complement(1823714..1825354) 1 NC_007384.1 ribose sensor receptor; Code: NT; COG: COG0840; methyl-accepting chemotaxis protein III 1825354 trg 3668369 trg Shigella sonnei Ss046 methyl-accepting chemotaxis protein III YP_310646.1 1823714 R 300269 CDS YP_310647.1 74312228 3668370 1825695..1825862 1 NC_007384.1 hypothetical protein 1825862 3668370 SSON_1722 Shigella sonnei Ss046 hypothetical protein YP_310647.1 1825695 D 300269 CDS YP_310648.1 74312229 3668371 complement(1825974..1826147) 1 NC_007384.1 hypothetical protein 1826147 ydcA 3668371 ydcA Shigella sonnei Ss046 hypothetical protein YP_310648.1 1825974 R 300269 CDS YP_310649.2 161986524 3668526 complement(1826392..1826922) 1 NC_007384.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 1826922 cybB 3668526 cybB Shigella sonnei Ss046 cytochrome b561 YP_310649.2 1826392 R 300269 CDS YP_310650.1 74312231 3668527 1827111..1828112 1 NC_007384.1 Code: G; COG: COG0057; glyceraldehyde-3-phosphate dehydrogenase 1828112 gapC 3668527 gapC Shigella sonnei Ss046 glyceraldehyde-3-phosphate dehydrogenase YP_310650.1 1827111 D 300269 CDS YP_310651.1 74312232 3668529 complement(1829221..1829934) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1829934 3668529 SSON_1727 Shigella sonnei Ss046 IS600 ORF2 YP_310651.1 1829221 R 300269 CDS YP_310652.1 74312233 3668530 1830088..1830390 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1830390 3668530 SSON_1728 Shigella sonnei Ss046 IS600 ORF1 YP_310652.1 1830088 D 300269 CDS YP_310653.1 74312234 3668531 complement(1830444..1830947) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1830947 3668531 SSON_1729 Shigella sonnei Ss046 IS1 ORF YP_310653.1 1830444 R 300269 CDS YP_310654.1 74312235 3668532 1831308..1832021 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1832021 3668532 SSON_1730 Shigella sonnei Ss046 IS600 ORF2 YP_310654.1 1831308 D 300269 CDS YP_310655.1 74312236 3668533 complement(1832119..1832421) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1832421 3668533 SSON_1731 Shigella sonnei Ss046 IS600 ORF1 YP_310655.1 1832119 R 300269 CDS YP_310656.1 74312237 3668534 complement(1832478..1833158) 1 NC_007384.1 Code: S; COG: COG1434; hypothetical protein 1833158 ydcF 3668534 ydcF Shigella sonnei Ss046 hypothetical protein YP_310656.1 1832478 R 300269 CDS YP_310657.1 74312238 3668535 complement(1833430..1837275) 1 NC_007384.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1837275 hrpA 3668535 hrpA Shigella sonnei Ss046 ATP-dependent RNA helicase HrpA YP_310657.1 1833430 R 300269 CDS YP_310658.1 74312239 3668536 1837533..1838138 1 NC_007384.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase 1838138 acpD 3668536 acpD Shigella sonnei Ss046 azoreductase YP_310658.1 1837533 D 300269 CDS YP_310659.1 74312240 3668537 complement(1838189..1839481) 1 NC_007384.1 Code: I; COG: COG0671; hypothetical protein 1839481 ynbD 3668537 ynbD Shigella sonnei Ss046 hypothetical protein YP_310659.1 1838189 R 300269 CDS YP_310660.1 74312241 3668538 complement(1839495..1841252) 1 NC_007384.1 Code: QR; COG: COG0500; hypothetical protein 1841252 3668538 SSON_1736 Shigella sonnei Ss046 hypothetical protein YP_310660.1 1839495 R 300269 CDS YP_310661.1 74312242 3668540 complement(1842184..1842897) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1842897 3668540 SSON_1738 Shigella sonnei Ss046 IS600 ORF2 YP_310661.1 1842184 R 300269 CDS YP_310662.1 74312243 3668541 complement(1843038..1843340) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1843340 3668541 SSON_1739 Shigella sonnei Ss046 IS600 ORF1 YP_310662.1 1843038 R 300269 CDS YP_310663.2 161986523 3668543 1844379..1845284 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1845284 3668543 SSON_1741 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_310663.2 1844379 D 300269 CDS YP_310664.1 74312245 3668544 complement(1845977..1846162) 1 NC_007384.1 hypothetical protein 1846162 ynbE 3668544 ynbE Shigella sonnei Ss046 hypothetical protein YP_310664.1 1845977 R 300269 CDS YP_310665.1 74312246 3668545 complement(1846159..1848798) 1 NC_007384.1 hypothetical protein 1848798 ydbH 3668545 ydbH Shigella sonnei Ss046 hypothetical protein YP_310665.1 1846159 R 300269 CDS YP_310666.1 74312247 3666424 1849006..1849995 1 NC_007384.1 Code: CHR; COG: COG1052; fermentative D-lactate dehydrogenase 1849995 ldhA 3666424 ldhA Shigella sonnei Ss046 fermentative D-lactate dehydrogenase YP_310666.1 1849006 D 300269 CDS YP_310667.1 74312248 3666425 1850106..1850528 1 NC_007384.1 Code: O; COG: COG3187; heat-inducible protein 1850528 hslJ 3666425 hslJ Shigella sonnei Ss046 heat-inducible protein YP_310667.1 1850106 D 300269 CDS YP_310668.1 74312249 3666426 complement(1850525..1850791) 1 NC_007384.1 Code: R; COG: COG3042; hypothetical protein 1850791 3666426 SSON_1746 Shigella sonnei Ss046 hypothetical protein YP_310668.1 1850525 R 300269 CDS YP_310669.1 74312250 3666427 1851064..1854588 1 NC_007384.1 Code: C; COG: COG0674; oxidoreductase, Fe-S subunit 1854588 ydbK 3666427 ydbK Shigella sonnei Ss046 oxidoreductase, Fe-S subunit YP_310669.1 1851064 D 300269 CDS YP_310670.1 74312251 3666428 1854954..1856087 1 NC_007384.1 Code: M; COG: COG3203; outer membrane protein 1856087 3666428 SSON_1748 Shigella sonnei Ss046 outer membrane protein YP_310670.1 1854954 D 300269 CDS YP_310671.1 74312252 3666429 1856156..1856662 1 NC_007384.1 Code: T; COG: COG0589; filament protein 1856662 ynaF 3666429 ynaF Shigella sonnei Ss046 filament protein YP_310671.1 1856156 D 300269 CDS YP_310672.1 74312253 3666430 1857248..1858162 1 NC_007384.1 periplasmic-binding protein; Code: P; COG: COG0803; Iron transport protein 1858162 sitA 3666430 sitA Shigella sonnei Ss046 Iron transport protein YP_310672.1 1857248 D 300269 CDS YP_310673.1 74312254 3666431 1858162..1858989 1 NC_007384.1 Code: P; COG: COG1121; iron ABC transporter ATP-binding protein 1858989 sitB 3666431 sitB Shigella sonnei Ss046 iron ABC transporter ATP-binding protein YP_310673.1 1858162 D 300269 CDS YP_310674.1 74312255 3666432 1858986..1859843 1 NC_007384.1 Code: P; COG: COG1108; iron transport protein inner membrane component 1859843 sitC 3666432 sitC Shigella sonnei Ss046 iron transport protein inner membrane component YP_310674.1 1858986 D 300269 CDS YP_310675.1 74312256 3666433 1859840..1860697 1 NC_007384.1 Code: P; COG: COG1108; Iron transport protein inner membrane component 1860697 sitD 3666433 sitD Shigella sonnei Ss046 Iron transport protein inner membrane component YP_310675.1 1859840 D 300269 CDS YP_310676.1 74312257 3666434 complement(1860898..1861521) 1 NC_007384.1 hypothetical protein 1861521 3666434 SSON_1754 Shigella sonnei Ss046 hypothetical protein YP_310676.1 1860898 R 300269 CDS YP_310677.1 74312258 3666435 complement(1862186..1862899) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1862899 3666435 SSON_1755 Shigella sonnei Ss046 IS600 ORF2 YP_310677.1 1862186 R 300269 CDS YP_310678.1 74312259 3666436 complement(1863040..1863342) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1863342 3666436 SSON_1756 Shigella sonnei Ss046 IS600 ORF1 YP_310678.1 1863040 R 300269 CDS YP_310679.1 74312260 3666437 complement(1863219..1863935) 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 1863935 3666437 SSON_1757 Shigella sonnei Ss046 IS21 ORF1 YP_310679.1 1863219 R 300269 CDS YP_310680.1 74312261 3666438 1864057..1864359 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1864359 3666438 SSON_1758 Shigella sonnei Ss046 IS600 ORF1 YP_310680.1 1864057 D 300269 CDS YP_310681.1 74312262 3666439 1864500..1865213 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1865213 3666439 SSON_1759 Shigella sonnei Ss046 IS600 ORF2 YP_310681.1 1864500 D 300269 CDS YP_310682.1 74312263 3666440 complement(1865254..1865583) 1 NC_007384.1 IS21 ORF1 1865583 3666440 SSON_1760 Shigella sonnei Ss046 IS21 ORF1 YP_310682.1 1865254 R 300269 CDS YP_310683.1 74312264 3666442 complement(1866060..1866659) 1 NC_007384.1 Code: M; COG: COG3637; hypothetical protein 1866659 3666442 SSON_1762 Shigella sonnei Ss046 hypothetical protein YP_310683.1 1866060 R 300269 CDS YP_310684.1 74312265 3668223 complement(1866727..1870206) 1 NC_007384.1 Code: S; COG: COG4733; host specificity protein 1870206 3668223 SSON_1763 Shigella sonnei Ss046 host specificity protein YP_310684.1 1866727 R 300269 CDS YP_310685.1 74312266 3668224 complement(1870267..1870809) 1 NC_007384.1 Code: S; COG: COG4723; prophage tail protein 1870809 3668224 SSON_1764 Shigella sonnei Ss046 prophage tail protein YP_310685.1 1870267 R 300269 CDS YP_310686.1 74312267 3668225 complement(1870806..1871549) 1 NC_007384.1 Code: M; COG: COG0791; tail assembly protein 1871549 3668225 SSON_1765 Shigella sonnei Ss046 tail assembly protein YP_310686.1 1870806 R 300269 CDS YP_310687.1 74312268 3668226 complement(1871554..1872252) 1 NC_007384.1 Code: S; COG: COG4672; minor tail protein 1872252 3668226 SSON_1766 Shigella sonnei Ss046 minor tail protein YP_310687.1 1871554 R 300269 CDS YP_310688.1 74312269 3668227 complement(1872262..1872591) 1 NC_007384.1 Code: S; COG: COG4718; minor tail protein 1872591 3668227 SSON_1767 Shigella sonnei Ss046 minor tail protein YP_310688.1 1872262 R 300269 CDS YP_310689.1 74312270 3668228 complement(1872591..1872956) 1 NC_007384.1 hypothetical protein 1872956 3668228 SSON_1768 Shigella sonnei Ss046 hypothetical protein YP_310689.1 1872591 R 300269 CDS YP_310690.1 74312271 3668229 1872995..1873297 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1873297 3668229 SSON_1769 Shigella sonnei Ss046 IS600 ORF1 YP_310690.1 1872995 D 300269 CDS YP_310691.1 74312272 3668230 1873474..1873776 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1873776 3668230 SSON_1770 Shigella sonnei Ss046 IS600 ORF1 YP_310691.1 1873474 D 300269 CDS YP_310692.1 74312273 3668231 1873812..1874237 1 NC_007384.1 IS600 ORF2 1874237 3668231 SSON_1771 Shigella sonnei Ss046 IS600 ORF2 YP_310692.1 1873812 D 300269 CDS YP_310693.1 74312274 3668232 1874227..1874451 1 NC_007384.1 IS600 ORF2 1874451 3668232 SSON_1772 Shigella sonnei Ss046 IS600 ORF2 YP_310693.1 1874227 D 300269 CDS YP_310694.1 74312275 3668237 complement(1875728..1876018) 1 NC_007384.1 bacteriophage protein 1876018 3668237 SSON_1777 Shigella sonnei Ss046 bacteriophage protein YP_310694.1 1875728 R 300269 CDS YP_310695.1 74312276 3667253 complement(1876018..1876617) 1 NC_007384.1 prophage protein 1876617 3667253 SSON_1778 Shigella sonnei Ss046 prophage protein YP_310695.1 1876018 R 300269 CDS YP_310696.1 74312277 3667254 1877202..1877705 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1877705 3667254 SSON_1779 Shigella sonnei Ss046 IS1 ORF YP_310696.1 1877202 D 300269 CDS YP_310697.1 74312278 3667255 complement(1878423..1878788) 1 NC_007384.1 prophage protein 1878788 3667255 SSON_1780 Shigella sonnei Ss046 prophage protein YP_310697.1 1878423 R 300269 CDS YP_310698.1 74312279 3667256 complement(1878788..1879453) 1 NC_007384.1 hypothetical protein 1879453 3667256 SSON_1781 Shigella sonnei Ss046 hypothetical protein YP_310698.1 1878788 R 300269 CDS YP_310699.1 74312280 3667257 complement(1879817..1880035) 1 NC_007384.1 hypothetical protein 1880035 3667257 SSON_1782 Shigella sonnei Ss046 hypothetical protein YP_310699.1 1879817 R 300269 CDS YP_310700.1 74312281 3667258 1880718..1881221 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1881221 3667258 SSON_1783 Shigella sonnei Ss046 IS1 ORF YP_310700.1 1880718 D 300269 CDS YP_310701.1 74312282 3667259 1881440..1881742 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1881742 3667259 SSON_1784 Shigella sonnei Ss046 IS600 ORF1 YP_310701.1 1881440 D 300269 CDS YP_310702.1 74312283 3667260 1881883..1882596 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1882596 3667260 SSON_1785 Shigella sonnei Ss046 IS600 ORF2 YP_310702.1 1881883 D 300269 CDS YP_310703.1 74312284 3667262 1883182..1884117 1 NC_007384.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1884117 ydaO 3667262 ydaO Shigella sonnei Ss046 C32 tRNA thiolase YP_310703.1 1883182 D 300269 CDS YP_310704.1 74312285 3667263 complement(1884246..1885619) 1 NC_007384.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA 1885619 dbpA 3667263 dbpA Shigella sonnei Ss046 ATP-dependent RNA helicase DbpA YP_310704.1 1884246 R 300269 CDS YP_310705.1 74312286 3667264 complement(1886097..1887080) 1 NC_007384.1 Code: P; COG: COG0598; zinc transporter 1887080 zntB 3667264 zntB Shigella sonnei Ss046 zinc transporter YP_310705.1 1886097 R 300269 CDS YP_310706.1 74312287 3667265 1887275..1888567 1 NC_007384.1 Code: T; COG: COG2199; hypothetical protein 1888567 3667265 SSON_1790 Shigella sonnei Ss046 hypothetical protein YP_310706.1 1887275 D 300269 CDS YP_310707.1 74312288 3667266 complement(1888588..1889151) 1 NC_007384.1 Code: S; COG: COG2840; hypothetical protein 1889151 ydaL 3667266 ydaL Shigella sonnei Ss046 hypothetical protein YP_310707.1 1888588 R 300269 CDS YP_310708.1 74312289 3667267 complement(1889481..1890389) 1 NC_007384.1 Code: K; COG: COG0583; DNA-binding transcriptional regulator 1890389 ydaK 3667267 ydaK Shigella sonnei Ss046 DNA-binding transcriptional regulator YP_310708.1 1889481 R 300269 CDS YP_310709.1 74312290 3667268 1890550..1891875 1 NC_007384.1 Code: R; COG: COG1473; aminohydrolase 1891875 ydaJ 3667268 ydaJ Shigella sonnei Ss046 aminohydrolase YP_310709.1 1890550 D 300269 CDS YP_310710.1 74312291 3667269 1891875..1893320 1 NC_007384.1 Code: R; COG: COG1473; hypothetical protein 1893320 3667269 SSON_1794 Shigella sonnei Ss046 hypothetical protein YP_310710.1 1891875 D 300269 CDS YP_310711.1 74312292 3667271 1894519..1894821 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1894821 3667271 SSON_1796 Shigella sonnei Ss046 IS600 ORF1 YP_310711.1 1894519 D 300269 CDS YP_310712.1 74312293 3667272 1894962..1895675 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1895675 3667272 SSON_1797 Shigella sonnei Ss046 IS600 ORF2 YP_310712.1 1894962 D 300269 CDS YP_310713.1 74312294 3666558 1896161..1896676 1 NC_007384.1 Code: L; COG: COG0350; O-6-alkylguanine-DNA:cysteine-protein methyltransferase 1896676 ogt 3666558 ogt Shigella sonnei Ss046 O-6-alkylguanine-DNA:cysteine-protein methyltransferase YP_310713.1 1896161 D 300269 CDS YP_310714.1 74312295 3666559 1896871..1897623 1 NC_007384.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 1897623 fnr 3666559 fnr Shigella sonnei Ss046 fumarate/nitrate reduction transcriptional regulator YP_310714.1 1896871 D 300269 CDS YP_310715.1 74312296 3666560 1897775..1898725 1 NC_007384.1 with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 1898725 ydaA 3666560 ydaA Shigella sonnei Ss046 universal stress protein UspE YP_310715.1 1897775 D 300269 CDS YP_310716.1 74312297 3666561 complement(1898775..1899032) 1 NC_007384.1 hypothetical protein 1899032 ynaJ 3666561 ynaJ Shigella sonnei Ss046 hypothetical protein YP_310716.1 1898775 R 300269 CDS YP_310717.1 74312298 3666563 complement(1899476..1899979) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1899979 3666563 SSON_1803 Shigella sonnei Ss046 IS1 ORF YP_310717.1 1899476 R 300269 CDS YP_310718.1 74312299 3666564 complement(1901136..1902770) 1 NC_007384.1 Code: E; COG: COG4166; transport periplasmic protein 1902770 3666564 SSON_1804 Shigella sonnei Ss046 transport periplasmic protein YP_310718.1 1901136 R 300269 CDS YP_310719.1 74312300 3666565 complement(1903086..1903985) 1 NC_007384.1 Code: K; COG: COG0583; LysR family transcriptional regulator 1903985 ycjZ 3666565 ycjZ Shigella sonnei Ss046 LysR family transcriptional regulator YP_310719.1 1903086 R 300269 CDS YP_310720.1 74312301 3666566 1904111..1905043 1 NC_007384.1 Code: R; COG: COG1073; hypothetical protein 1905043 3666566 SSON_1806 Shigella sonnei Ss046 hypothetical protein YP_310720.1 1904111 D 300269 CDS YP_310721.1 74312302 3666567 1905043..1905546 1 NC_007384.1 Code: R; COG: COG1073; dienelactone hydrolase and related enzymes 1905546 3666567 SSON_1807 Shigella sonnei Ss046 dienelactone hydrolase and related enzymes YP_310721.1 1905043 D 300269 CDS YP_310722.1 74312303 3666568 1905769..1906272 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1906272 3666568 SSON_1808 Shigella sonnei Ss046 IS1 ORF YP_310722.1 1905769 D 300269 CDS YP_310723.1 74312304 3666569 1906303..1906752 1 NC_007384.1 Code: R; COG: COG1073; hypothetical protein 1906752 3666569 SSON_1809 Shigella sonnei Ss046 hypothetical protein YP_310723.1 1906303 D 300269 CDS YP_310724.1 74312305 3666570 1906770..1907408 1 NC_007384.1 Code: MG; COG: COG0702; hypothetical protein 1907408 3666570 SSON_1810 Shigella sonnei Ss046 hypothetical protein YP_310724.1 1906770 D 300269 CDS YP_310725.1 74312306 3666571 complement(1907707..1908210) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1908210 3666571 SSON_1811 Shigella sonnei Ss046 IS1 ORF YP_310725.1 1907707 R 300269 CDS YP_310726.1 74312307 3666572 1908495..1909223 1 NC_007384.1 Code: E; COG: COG2866; murein peptide amidase A 1909223 ycjI 3666572 ycjI Shigella sonnei Ss046 murein peptide amidase A YP_310726.1 1908495 D 300269 CDS YP_310727.1 74312308 3666573 complement(1909255..1910163) 1 NC_007384.1 Code: MR; COG: COG4948; muconate cycloisomerase I 1910163 ycjG 3666573 ycjG Shigella sonnei Ss046 muconate cycloisomerase I YP_310727.1 1909255 R 300269 CDS YP_310728.1 74312309 3666574 1910282..1910788 1 NC_007384.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1910788 tpx 3666574 tpx Shigella sonnei Ss046 thiol peroxidase YP_310728.1 1910282 D 300269 CDS YP_310729.1 74312310 3666575 complement(1910832..1912373) 1 NC_007384.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1912373 tyrR 3666575 tyrR Shigella sonnei Ss046 DNA-binding transcriptional regulator TyrR YP_310729.1 1910832 R 300269 CDS YP_310730.1 74312311 3666576 complement(1912534..1913037) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1913037 3666576 SSON_1816 Shigella sonnei Ss046 IS1 ORF YP_310730.1 1912534 R 300269 CDS YP_310731.1 74312312 3666765 complement(1913297..1914358) 1 NC_007384.1 Code: S; COG: COG3768; hypothetical protein 1914358 ycjF 3666765 ycjF Shigella sonnei Ss046 hypothetical protein YP_310731.1 1913297 R 300269 CDS YP_310732.1 74312313 3666766 complement(1914355..1915752) 1 NC_007384.1 Code: R; COG: COG3106; hypothetical protein 1915752 ycjX 3666766 ycjX Shigella sonnei Ss046 hypothetical protein YP_310732.1 1914355 R 300269 CDS YP_310733.1 74312314 3666767 1915907..1916905 1 NC_007384.1 Code: K; COG: COG1609; LACI-type transcriptional regulator 1916905 ycjW 3666767 ycjW Shigella sonnei Ss046 LACI-type transcriptional regulator YP_310733.1 1915907 D 300269 CDS YP_310734.1 74312315 3666769 complement(1917792..1918295) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1918295 3666769 SSON_1821 Shigella sonnei Ss046 IS1 ORF YP_310734.1 1917792 R 300269 CDS YP_310735.1 74312316 3666771 complement(1919278..1919937) 1 NC_007384.1 Code: R; COG: COG0637; beta-phosphoglucomutase 1919937 ycjU 3666771 ycjU Shigella sonnei Ss046 beta-phosphoglucomutase YP_310735.1 1919278 R 300269 CDS YP_310736.1 74312317 3666772 complement(1919934..1922201) 1 NC_007384.1 Code: G; COG: COG1554; hypothetical protein 1922201 ycjT 3666772 ycjT Shigella sonnei Ss046 hypothetical protein YP_310736.1 1919934 R 300269 CDS YP_310737.1 74312318 3666773 complement(1922198..1923253) 1 NC_007384.1 Code: R; COG: COG0673; dehydrogenase 1923253 ycjS 3666773 ycjS Shigella sonnei Ss046 dehydrogenase YP_310737.1 1922198 R 300269 CDS YP_310738.1 74312319 3666774 complement(1923263..1924051) 1 NC_007384.1 Code: G; COG: COG1082; hypothetical protein 1924051 3666774 SSON_1826 Shigella sonnei Ss046 hypothetical protein YP_310738.1 1923263 R 300269 CDS YP_310739.1 74312320 3666775 complement(1924069..1925121) 1 NC_007384.1 Code: ER; COG: COG1063; oxidoreductase 1925121 ycjQ 3666775 ycjQ Shigella sonnei Ss046 oxidoreductase YP_310739.1 1924069 R 300269 CDS YP_310740.1 74312321 3666777 complement(1925742..1926623) 1 NC_007384.1 Code: G; COG: COG1175; binding-protein dependent transport protein 1926623 ycjO 3666777 ycjO Shigella sonnei Ss046 binding-protein dependent transport protein YP_310740.1 1925742 R 300269 CDS YP_310741.1 74312322 3666778 complement(1926644..1927954) 1 NC_007384.1 Code: G; COG: COG1653; transport periplasmic protein 1927954 3666778 SSON_1830 Shigella sonnei Ss046 transport periplasmic protein YP_310741.1 1926644 R 300269 CDS YP_310742.1 74312323 3666780 complement(1929711..1930025) 1 NC_007384.1 rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 1930025 pspE 3666780 pspE Shigella sonnei Ss046 thiosulfate:cyanide sulfurtransferase YP_310742.1 1929711 R 300269 CDS YP_310743.1 74312324 3666781 complement(1930100..1930321) 1 NC_007384.1 peripheral inner membrane phage-shock protein 1930321 pspD 3666781 pspD Shigella sonnei Ss046 peripheral inner membrane phage-shock protein YP_310743.1 1930100 R 300269 CDS YP_310744.1 74312325 3666782 complement(1930330..1930689) 1 NC_007384.1 activates phage shock-protein expression; with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; DNA-binding transcriptional activator PspC 1930689 pspC 3666782 pspC Shigella sonnei Ss046 DNA-binding transcriptional activator PspC YP_310744.1 1930330 R 300269 CDS YP_310745.1 74312326 3666783 complement(1930689..1930913) 1 NC_007384.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B 1930913 pspB 3666783 pspB Shigella sonnei Ss046 phage shock protein B YP_310745.1 1930689 R 300269 CDS YP_310746.1 74312327 3666784 complement(1930967..1931635) 1 NC_007384.1 inner membrane protein; involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 1931635 pspA 3666784 pspA Shigella sonnei Ss046 phage shock protein PspA YP_310746.1 1930967 R 300269 CDS YP_310747.2 161986522 3667409 1931802..1932779 1 NC_007384.1 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator 1932779 pspF 3667409 pspF Shigella sonnei Ss046 phage shock protein operon transcriptional activator YP_310747.2 1931802 D 300269 CDS YP_310748.1 74312329 3667411 complement(1934200..1935480) 1 NC_007384.1 Code: E; COG: COG0665; oxidoreductase 1935480 ordL 3667411 ordL Shigella sonnei Ss046 oxidoreductase YP_310748.1 1934200 R 300269 CDS YP_310749.1 74312330 3667412 complement(1935482..1936831) 1 NC_007384.1 prefers NADP over NAD; Code: C; COG: COG1012; aldehyde dehydrogenase 1936831 aldH 3667412 aldH Shigella sonnei Ss046 aldehyde dehydrogenase YP_310749.1 1935482 R 300269 CDS YP_310750.1 74312331 3667413 complement(1937122..1937679) 1 NC_007384.1 regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR 1937679 ycjC 3667413 ycjC Shigella sonnei Ss046 DNA-binding transcriptional repressor PuuR YP_310750.1 1937122 R 300269 CDS YP_310751.1 74312332 3667414 complement(1937706..1938482) 1 NC_007384.1 catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate; gamma-glutamyl-gamma-aminobutyrate hydrolase 1938482 puuD 3667414 puuD Shigella sonnei Ss046 gamma-glutamyl-gamma-aminobutyrate hydrolase YP_310751.1 1937706 R 300269 CDS YP_310752.1 74312333 3667415 1938604..1940043 1 NC_007384.1 Code: E; COG: COG0174; glutamine synthetase 1940043 3667415 SSON_1843 Shigella sonnei Ss046 glutamine synthetase YP_310752.1 1938604 D 300269 CDS YP_310753.1 74312334 3667416 1940292..1941731 1 NC_007384.1 Code: E; COG: COG0531; amino acid/amine transport protein 1941731 ycjJ 3667416 ycjJ Shigella sonnei Ss046 amino acid/amine transport protein YP_310753.1 1940292 D 300269 CDS YP_310754.1 74312335 3667417 1941865..1942110 1 NC_007384.1 hypothetical protein 1942110 ymjA 3667417 ymjA Shigella sonnei Ss046 hypothetical protein YP_310754.1 1941865 D 300269 CDS YP_310755.1 74312336 3667418 1942423..1944066 1 NC_007384.1 similar to Salmonella peptide transport periplasmic protein; Code: E; COG: COG4166; peptide transport periplasmic protein-like protein 1944066 sapA 3667418 sapA Shigella sonnei Ss046 peptide transport periplasmic protein-like protein YP_310755.1 1942423 D 300269 CDS YP_310756.1 74312337 3667419 1944063..1945028 1 NC_007384.1 similar to Salmonella peptide transport periplasmic protein; Code: V; COG: COG4168; peptide transport permease-like protein 1945028 sapB 3667419 sapB Shigella sonnei Ss046 peptide transport permease-like protein YP_310756.1 1944063 D 300269 CDS YP_310757.1 74312338 3667420 1945015..1945905 1 NC_007384.1 similar to Salmonella peptide transport periplasmic protein; Code: V; COG: COG4171; peptide transport permease-like protein 1945905 sapC 3667420 sapC Shigella sonnei Ss046 peptide transport permease-like protein YP_310757.1 1945015 D 300269 CDS YP_310758.1 74312339 3667421 1945905..1946897 1 NC_007384.1 Code: V; COG: COG4170; peptide ABC transporter ATP-binding protein 1946897 sapD 3667421 sapD Shigella sonnei Ss046 peptide ABC transporter ATP-binding protein YP_310758.1 1945905 D 300269 CDS YP_310759.1 74312340 3667422 1946899..1947705 1 NC_007384.1 Code: V; COG: COG4167; peptide ABC transporter ATP-binding protein 1947705 sapF 3667422 sapF Shigella sonnei Ss046 peptide ABC transporter ATP-binding protein YP_310759.1 1946899 D 300269 CDS YP_310760.1 74312341 3667423 1947773..1948126 1 NC_007384.1 Code: S; COG: COG2852; hypothetical protein 1948126 ycjD 3667423 ycjD Shigella sonnei Ss046 hypothetical protein YP_310760.1 1947773 D 300269 CDS YP_310761.1 74312342 3667424 1948494..1949282 1 NC_007384.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase 1949282 fabI 3667424 fabI Shigella sonnei Ss046 enoyl-ACP reductase YP_310761.1 1948494 D 300269 CDS YP_310762.1 74312343 3667426 1950621..1952555 1 NC_007384.1 mRNA degradation; Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II 1952555 rnb 3667426 rnb Shigella sonnei Ss046 exoribonuclease II YP_310762.1 1950621 D 300269 CDS YP_310763.1 74312344 3666895 1955190..1955939 1 NC_007384.1 Code: KG; COG: COG1349; DeoR-type transcriptional regulator 1955939 3666895 SSON_1856 Shigella sonnei Ss046 DeoR-type transcriptional regulator YP_310763.1 1955190 D 300269 CDS YP_310764.1 74312345 3666896 1956208..1956426 1 NC_007384.1 lipoprotein 1956426 osmB 3666896 osmB Shigella sonnei Ss046 lipoprotein YP_310764.1 1956208 D 300269 CDS YP_310765.1 74312346 3666897 complement(1956552..1956881) 1 NC_007384.1 involved in start site selection during the initiation of translation; translation initiation factor Sui1 1956881 yciH 3666897 yciH Shigella sonnei Ss046 translation initiation factor Sui1 YP_310765.1 1956552 R 300269 CDS YP_310766.1 74312347 3666898 complement(1956878..1957615) 1 NC_007384.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1957615 pyrF 3666898 pyrF Shigella sonnei Ss046 orotidine 5'-phosphate decarboxylase YP_310766.1 1956878 R 300269 CDS YP_310767.1 74312348 3666899 complement(1957808..1958977) 1 NC_007384.1 Code: G; COG: COG2956; hypothetical protein 1958977 yciM 3666899 yciM Shigella sonnei Ss046 hypothetical protein YP_310767.1 1957808 R 300269 CDS YP_310768.1 74312349 3666900 complement(1958984..1959292) 1 NC_007384.1 Code: S; COG: COG3771; hypothetical protein 1959292 yciS 3666900 yciS Shigella sonnei Ss046 hypothetical protein YP_310768.1 1958984 R 300269 CDS YP_310769.1 74312350 3666901 complement(1959442..1960206) 1 NC_007384.1 Code: I; COG: COG0671; phosphatidylglycerophosphatase B 1960206 pgpB 3666901 pgpB Shigella sonnei Ss046 phosphatidylglycerophosphatase B YP_310769.1 1959442 R 300269 CDS YP_310770.1 74312351 3666902 1960376..1960966 1 NC_007384.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 1960966 ribA 3666902 ribA Shigella sonnei Ss046 GTP cyclohydrolase II YP_310770.1 1960376 D 300269 CDS YP_310771.1 74312352 3666903 complement(1961030..1963705) 1 NC_007384.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1963705 acnA 3666903 acnA Shigella sonnei Ss046 aconitate hydratase YP_310771.1 1961030 R 300269 CDS YP_310772.1 74312353 3666904 complement(1964078..1964257) 1 NC_007384.1 hypothetical protein 1964257 3666904 SSON_1865 Shigella sonnei Ss046 hypothetical protein YP_310772.1 1964078 R 300269 CDS YP_310773.1 74312354 3666905 complement(1964248..1964412) 1 NC_007384.1 hypothetical protein 1964412 3666905 SSON_1866 Shigella sonnei Ss046 hypothetical protein YP_310773.1 1964248 R 300269 CDS YP_310774.1 74312355 3666906 1964730..1965233 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1965233 3666906 SSON_1867 Shigella sonnei Ss046 IS1 ORF YP_310774.1 1964730 D 300269 CDS YP_310775.1 74312356 3666907 complement(1965483..1966457) 1 NC_007384.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1966457 cysB 3666907 cysB Shigella sonnei Ss046 transcriptional regulator CysB YP_310775.1 1965483 R 300269 CDS YP_310776.1 74312357 3666908 complement(1966667..1969264) 1 NC_007384.1 omega protein; catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1969264 topA 3666908 topA Shigella sonnei Ss046 DNA topoisomerase I YP_310776.1 1966667 R 300269 CDS YP_310777.1 74312358 3666909 1969644..1969895 1 NC_007384.1 hypothetical protein 1969895 yciN 3666909 yciN Shigella sonnei Ss046 hypothetical protein YP_310777.1 1969644 D 300269 CDS YP_310778.1 74312359 3666910 complement(1969931..1970980) 1 NC_007384.1 SohB; periplasmic protein; member of the peptidase S49 family; periplasmic protease 1970980 sohB 3666910 sohB Shigella sonnei Ss046 periplasmic protease YP_310778.1 1969931 R 300269 CDS YP_310779.1 74312360 3666911 1971200..1971958 1 NC_007384.1 Code: IQR; COG: COG1028; short chain dehydrogenase 1971958 yciK 3666911 yciK Shigella sonnei Ss046 short chain dehydrogenase YP_310779.1 1971200 D 300269 CDS YP_310780.1 74312361 3666912 1971955..1972545 1 NC_007384.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 1972545 btuR 3666912 btuR Shigella sonnei Ss046 cob(I)yrinic acid a,c-diamide adenosyltransferase YP_310780.1 1971955 D 300269 CDS YP_310781.1 74312362 3666913 complement(1972585..1973457) 1 NC_007384.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1973457 yciL 3666913 yciL Shigella sonnei Ss046 23S rRNA pseudouridylate synthase B YP_310781.1 1972585 R 300269 CDS YP_310782.1 74312363 3668599 complement(1974812..1975468) 1 NC_007384.1 Code: J; COG: COG0009; hypothetical protein 1975468 yciO 3668599 yciO Shigella sonnei Ss046 hypothetical protein YP_310782.1 1974812 R 300269 CDS YP_310783.1 74312364 3668600 complement(1975429..1976310) 1 NC_007384.1 Code: R; COG: COG0613; hypothetical protein 1976310 yciV 3668600 yciV Shigella sonnei Ss046 hypothetical protein YP_310783.1 1975429 R 300269 CDS YP_310785.1 74312366 3668602 1976584..1978146 1 NC_007384.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1978146 trpE 3668602 trpE Shigella sonnei Ss046 anthranilate synthase component I YP_310785.1 1976584 D 300269 CDS YP_310786.1 74312367 3668603 1978146..1979741 1 NC_007384.1 glutamine amidotransferase and phosphoribosylanthranilate transferase; bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase 1979741 trpD 3668603 trpD Shigella sonnei Ss046 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase YP_310786.1 1978146 D 300269 CDS YP_310787.1 74312368 3668604 1979742..1981103 1 NC_007384.1 indole-3-glycerolphosphate synthetase; monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1981103 trpC 3668604 trpC Shigella sonnei Ss046 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase YP_310787.1 1979742 D 300269 CDS YP_310788.1 74312369 3668605 1981115..1982308 1 NC_007384.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1982308 trpB 3668605 trpB Shigella sonnei Ss046 tryptophan synthase subunit beta YP_310788.1 1981115 D 300269 CDS YP_310789.1 74312370 3668606 1982308..1983114 1 NC_007384.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1983114 trpA 3668606 trpA Shigella sonnei Ss046 tryptophan synthase subunit alpha YP_310789.1 1982308 D 300269 CDS YP_310790.1 74312371 3668607 1983467..1983970 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 1983970 3668607 SSON_1884 Shigella sonnei Ss046 IS1 ORF YP_310790.1 1983467 D 300269 CDS YP_310791.1 74312372 3668608 1984562..1985119 1 NC_007384.1 hypothetical protein 1985119 3668608 SSON_1885 Shigella sonnei Ss046 hypothetical protein YP_310791.1 1984562 D 300269 CDS YP_310792.1 74312373 3668609 1985869..1986525 1 NC_007384.1 Code: QR; COG: COG0500; prophage protein 1986525 3668609 SSON_1886 Shigella sonnei Ss046 prophage protein YP_310792.1 1985869 D 300269 CDS YP_310793.1 74312374 3668610 1987134..1987745 1 NC_007384.1 bacteriophage tail protein 1987745 3668610 SSON_1887 Shigella sonnei Ss046 bacteriophage tail protein YP_310793.1 1987134 D 300269 CDS YP_310794.1 74312375 3668611 1987898..1988431 1 NC_007384.1 tail fiber assembly protein 1988431 3668611 SSON_1888 Shigella sonnei Ss046 tail fiber assembly protein YP_310794.1 1987898 D 300269 CDS YP_310795.1 74312376 3668612 complement(1988460..1988987) 1 NC_007384.1 tail fiber assembly protein 1988987 3668612 SSON_1889 Shigella sonnei Ss046 tail fiber assembly protein YP_310795.1 1988460 R 300269 CDS YP_310796.1 74312377 3668613 1989342..1989644 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1989644 3668613 SSON_1890 Shigella sonnei Ss046 IS600 ORF1 YP_310796.1 1989342 D 300269 CDS YP_310797.1 74312378 3668614 1989785..1990498 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1990498 3668614 SSON_1891 Shigella sonnei Ss046 IS600 ORF2 YP_310797.1 1989785 D 300269 CDS YP_310798.1 74312379 3668615 complement(1990932..1991246) 1 NC_007384.1 hypothetical protein 1991246 3668615 SSON_1892 Shigella sonnei Ss046 hypothetical protein YP_310798.1 1990932 R 300269 CDS YP_310799.1 74312380 3668616 complement(1991617..1993470) 1 NC_007384.1 Code: L; COG: COG2801; prophage protein 1993470 3668616 SSON_1893 Shigella sonnei Ss046 prophage protein YP_310799.1 1991617 R 300269 CDS YP_310800.1 74312381 3668617 1994069..1994371 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 1994371 3668617 SSON_1894 Shigella sonnei Ss046 IS600 ORF1 YP_310800.1 1994069 D 300269 CDS YP_310801.1 74312382 3668830 1994512..1995225 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 1995225 3668830 SSON_1895 Shigella sonnei Ss046 IS600 ORF2 YP_310801.1 1994512 D 300269 CDS YP_310802.1 74312383 3668834 complement(1996003..1997061) 1 NC_007384.1 Code: L; COG: COG0863; DNA adenine methyltransferase encoded by prophage 1997061 3668834 SSON_1899 Shigella sonnei Ss046 DNA adenine methyltransferase encoded by prophage YP_310802.1 1996003 R 300269 CDS YP_310803.1 74312384 3668835 complement(1997212..1997409) 1 NC_007384.1 bacteriophage protein 1997409 3668835 SSON_1900 Shigella sonnei Ss046 bacteriophage protein YP_310803.1 1997212 R 300269 CDS YP_310804.1 74312385 3668836 complement(1997634..1998455) 1 NC_007384.1 similar to cryptic prophage protein; antitermination protein Q-like protein 1998455 3668836 SSON_1901 Shigella sonnei Ss046 antitermination protein Q-like protein YP_310804.1 1997634 R 300269 CDS YP_310805.1 74312386 3668837 complement(1998452..1998832) 1 NC_007384.1 Code: L; COG: COG4570; endonuclease of cryptic prophage 1998832 3668837 SSON_1902 Shigella sonnei Ss046 endonuclease of cryptic prophage YP_310805.1 1998452 R 300269 CDS YP_310806.1 74312387 3668838 complement(1998833..1999891) 1 NC_007384.1 hypothetical protein 1999891 3668838 SSON_1903 Shigella sonnei Ss046 hypothetical protein YP_310806.1 1998833 R 300269 CDS YP_310807.1 74312388 3668839 complement(2000469..2000624) 1 NC_007384.1 polypeptide destructive to membrane potential 2000624 relF 3668839 relF Shigella sonnei Ss046 polypeptide destructive to membrane potential YP_310807.1 2000469 R 300269 CDS YP_310808.1 74312389 3668840 complement(2001435..2001665) 1 NC_007384.1 prophage protein 2001665 3668840 SSON_1905 Shigella sonnei Ss046 prophage protein YP_310808.1 2001435 R 300269 CDS YP_310809.1 74312390 3668841 complement(2001677..2002390) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 2002390 3668841 SSON_1906 Shigella sonnei Ss046 IS600 ORF2 YP_310809.1 2001677 R 300269 CDS YP_310810.1 74312391 3668842 complement(2002531..2002833) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 2002833 3668842 SSON_1907 Shigella sonnei Ss046 IS600 ORF1 YP_310810.1 2002531 R 300269 CDS YP_310811.1 74312392 3668843 2003609..2004112 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2004112 3668843 SSON_1908 Shigella sonnei Ss046 IS1 ORF YP_310811.1 2003609 D 300269 CDS YP_310812.1 74312393 3668844 2004171..2004383 1 NC_007384.1 prophage protein 2004383 3668844 SSON_1909 Shigella sonnei Ss046 prophage protein YP_310812.1 2004171 D 300269 CDS YP_310813.1 74312394 3668845 complement(2005055..2005693) 1 NC_007384.1 receptor for colicin S4; outer membrane protein W 2005693 yciD 3668845 yciD Shigella sonnei Ss046 outer membrane protein W YP_310813.1 2005055 R 300269 CDS YP_310814.1 74312395 3668086 2006050..2006793 1 NC_007384.1 hypothetical protein 2006793 yciC 3668086 yciC Shigella sonnei Ss046 hypothetical protein YP_310814.1 2006050 D 300269 CDS YP_310815.1 74312396 3668087 2006823..2007362 1 NC_007384.1 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 2007362 yciB 3668087 yciB Shigella sonnei Ss046 intracellular septation protein A YP_310815.1 2006823 D 300269 CDS YP_310816.1 74312397 3668088 2007467..2007865 1 NC_007384.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins; acyl-CoA thioester hydrolase 2007865 yciA 3668088 yciA Shigella sonnei Ss046 acyl-CoA thioester hydrolase YP_310816.1 2007467 D 300269 CDS YP_310817.1 74312398 3668089 complement(2007905..2008624) 1 NC_007384.1 energy transducer; uptake of iron, cyanocobalimin; sensitivity to phages, colicins; membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transporter 2008624 tonB 3668089 tonB Shigella sonnei Ss046 transporter YP_310817.1 2007905 R 300269 CDS YP_310818.1 74312399 3668090 2008715..2010235 1 NC_007384.1 hypothetical protein 2010235 3668090 SSON_1915 Shigella sonnei Ss046 hypothetical protein YP_310818.1 2008715 D 300269 CDS YP_310819.2 161986521 3668091 2011066..2011971 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2011971 3668091 SSON_1916 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_310819.2 2011066 D 300269 CDS YP_310820.1 74312401 3668092 complement(2012548..2012982) 1 NC_007384.1 hypothetical protein 2012982 3668092 SSON_1917 Shigella sonnei Ss046 hypothetical protein YP_310820.1 2012548 R 300269 CDS YP_310821.1 74312402 3668093 complement(2012994..2013707) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 2013707 3668093 SSON_1918 Shigella sonnei Ss046 IS600 ORF2 YP_310821.1 2012994 R 300269 CDS YP_310822.1 74312403 3668094 complement(2013848..2014150) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 2014150 3668094 SSON_1919 Shigella sonnei Ss046 IS600 ORF1 YP_310822.1 2013848 R 300269 CDS YP_310823.1 74312404 3668095 2014725..2015756 1 NC_007384.1 Code: L; COG: COG3335; IS630 orf 2015756 3668095 SSON_1920 Shigella sonnei Ss046 IS630 orf YP_310823.1 2014725 D 300269 CDS YP_310824.1 74312405 3668096 complement(2015762..2017039) 1 NC_007384.1 hypothetical protein 2017039 3668096 SSON_1921 Shigella sonnei Ss046 hypothetical protein YP_310824.1 2015762 R 300269 CDS YP_310825.1 74312406 3668097 complement(2017428..2018138) 1 NC_007384.1 hypothetical protein 2018138 3668097 SSON_1922 Shigella sonnei Ss046 hypothetical protein YP_310825.1 2017428 R 300269 CDS YP_310826.1 74312407 3668098 complement(2018654..2018869) 1 NC_007384.1 hypothetical protein 2018869 3668098 SSON_1923 Shigella sonnei Ss046 hypothetical protein YP_310826.1 2018654 R 300269 CDS YP_310827.1 74312408 3668099 complement(2018914..2019417) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2019417 3668099 SSON_1924 Shigella sonnei Ss046 IS1 ORF YP_310827.1 2018914 R 300269 CDS YP_310828.1 74312409 3668100 complement(2020687..2021244) 1 NC_007384.1 hypothetical protein 2021244 3668100 SSON_1925 Shigella sonnei Ss046 hypothetical protein YP_310828.1 2020687 R 300269 CDS YP_310829.1 74312410 3668101 complement(2022807..2023358) 1 NC_007384.1 Code: L; COG: COG1961; resolvase 2023358 3668101 SSON_1926 Shigella sonnei Ss046 resolvase YP_310829.1 2022807 R 300269 CDS YP_310830.2 161986520 3668102 2024157..2024453 1 NC_007384.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; hypothetical protein 2024453 yciI 3668102 yciI Shigella sonnei Ss046 hypothetical protein YP_310830.2 2024157 D 300269 CDS YP_310831.1 74312412 3668103 complement(2024555..2025268) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 2025268 3668103 SSON_1928 Shigella sonnei Ss046 IS600 ORF2 YP_310831.1 2024555 R 300269 CDS YP_310832.1 74312413 3668104 complement(2025409..2025711) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 2025711 3668104 SSON_1929 Shigella sonnei Ss046 IS600 ORF1 YP_310832.1 2025409 R 300269 CDS YP_310833.1 74312414 3668105 2026020..2027273 1 NC_007384.1 Code: P; COG: COG1226; voltage-gated potassium channel 2027273 kch 3668105 kch Shigella sonnei Ss046 voltage-gated potassium channel YP_310833.1 2026020 D 300269 CDS YP_310834.1 74312415 3667712 2027644..2029104 1 NC_007384.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase 2029104 cls 3667712 cls Shigella sonnei Ss046 cardiolipin synthetase YP_310834.1 2027644 D 300269 CDS YP_310835.2 161986519 3667713 2029139..2029468 1 NC_007384.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 2029468 3667713 SSON_1932 Shigella sonnei Ss046 dsDNA-mimic protein YP_310835.2 2029139 D 300269 CDS YP_310836.1 74312417 3667714 complement(2029521..2030525) 1 NC_007384.1 Code: E; COG: COG4608; peptide ABC transporter ATP-binding protein 2030525 oppF 3667714 oppF Shigella sonnei Ss046 peptide ABC transporter ATP-binding protein YP_310836.1 2029521 R 300269 CDS YP_310837.1 74312418 3667715 complement(2030522..2031535) 1 NC_007384.1 Code: EP; COG: COG0444; oligopeptide transporter ATP-binding protein 2031535 oppD 3667715 oppD Shigella sonnei Ss046 oligopeptide transporter ATP-binding protein YP_310837.1 2030522 R 300269 CDS YP_310838.1 74312419 3667716 complement(2031547..2032455) 1 NC_007384.1 similar to Salmonella oligopeptide transport permease protein; Code: EP; COG: COG1173; oligopeptide transport permease-like protein 2032455 oppC 3667716 oppC Shigella sonnei Ss046 oligopeptide transport permease-like protein YP_310838.1 2031547 R 300269 CDS YP_310839.1 74312420 3667717 complement(2032470..2033390) 1 NC_007384.1 Code: EP; COG: COG0601; oligopeptide transporter permease 2033390 oppB 3667717 oppB Shigella sonnei Ss046 oligopeptide transporter permease YP_310839.1 2032470 R 300269 CDS YP_310840.1 74312421 3667718 complement(2033476..2035107) 1 NC_007384.1 Code: E; COG: COG4166; oligopeptide transport periplasmic binding protein 2035107 oppA 3667718 oppA Shigella sonnei Ss046 oligopeptide transport periplasmic binding protein YP_310840.1 2033476 R 300269 CDS YP_310841.1 74312422 3667719 complement(2035845..2036492) 1 NC_007384.1 Code: U; COG: COG2095; hypothetical protein 2036492 ychE 3667719 ychE Shigella sonnei Ss046 hypothetical protein YP_310841.1 2035845 R 300269 CDS YP_310842.1 74312423 3667720 2036970..2039645 1 NC_007384.1 Code: C; COG: COG1454; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 2039645 adhE 3667720 adhE Shigella sonnei Ss046 bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_310842.1 2036970 D 300269 CDS YP_310843.1 74312424 3667721 complement(2039700..2041046) 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 2041046 3667721 SSON_1940 Shigella sonnei Ss046 IS4 orf YP_310843.1 2039700 R 300269 CDS YP_310844.1 74312425 3667722 complement(2041385..2042002) 1 NC_007384.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 2042002 tdk 3667722 tdk Shigella sonnei Ss046 thymidine kinase YP_310844.1 2041385 R 300269 CDS YP_310845.1 74312426 3667723 2042607..2043020 1 NC_007384.1 HU, BH2, HD, NS; pleiotropic regulator; Code: R; COG: COG2916; global DNA-binding transcriptional dual regulator H-NS 2043020 hns 3667723 hns Shigella sonnei Ss046 global DNA-binding transcriptional dual regulator H-NS YP_310845.1 2042607 D 300269 CDS YP_310846.1 74312427 3667724 complement(2043164..2044072) 1 NC_007384.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase 2044072 galU 3667724 galU Shigella sonnei Ss046 UTP-glucose-1-phosphate uridylyltransferase YP_310846.1 2043164 R 300269 CDS YP_310847.1 74312428 3667725 complement(2044274..2045287) 1 NC_007384.1 Code: T; COG: COG0784; response regulator of RpoS 2045287 hnr 3667725 hnr Shigella sonnei Ss046 response regulator of RpoS YP_310847.1 2044274 R 300269 CDS YP_310848.1 74312429 3667726 complement(2045379..2046323) 1 NC_007384.1 Code: R; COG: COG1752; hypothetical protein 2046323 ychK 3667726 ychK Shigella sonnei Ss046 hypothetical protein YP_310848.1 2045379 R 300269 CDS YP_310849.1 74312430 3667727 2046397..2046855 1 NC_007384.1 Code: S; COG: COG3012; hypothetical protein 2046855 ychJ 3667727 ychJ Shigella sonnei Ss046 hypothetical protein YP_310849.1 2046397 D 300269 CDS YP_310850.1 74312431 3667728 2046905..2047747 1 NC_007384.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 2047747 purU 3667728 purU Shigella sonnei Ss046 formyltetrahydrofolate deformylase YP_310850.1 2046905 D 300269 CDS YP_310851.1 74312432 3667900 complement(2048354..2049031) 1 NC_007384.1 Code: C; COG: COG2181; nitrate reductase 1, cytochrome b(NR) subunit gamma 2049031 narI 3667900 narI Shigella sonnei Ss046 nitrate reductase 1, cytochrome b(NR) subunit gamma YP_310851.1 2048354 R 300269 CDS YP_310852.1 74312433 3667901 complement(2049031..2049741) 1 NC_007384.1 Code: C; COG: COG2180; nitrate reductase 1 subunit delta 2049741 narJ 3667901 narJ Shigella sonnei Ss046 nitrate reductase 1 subunit delta YP_310852.1 2049031 R 300269 CDS YP_310853.1 74312434 3667902 complement(2049738..2051276) 1 NC_007384.1 Code: C; COG: COG1140; nitrate reductase 1 subunit beta 2051276 narH 3667902 narH Shigella sonnei Ss046 nitrate reductase 1 subunit beta YP_310853.1 2049738 R 300269 CDS YP_310854.1 74312435 3667903 complement(2051273..2055016) 1 NC_007384.1 Code: C; COG: COG5013; nitrate reductase 1 subunit alpha 2055016 narG 3667903 narG Shigella sonnei Ss046 nitrate reductase 1 subunit alpha YP_310854.1 2051273 R 300269 CDS YP_310855.1 74312436 3667904 complement(2055409..2056800) 1 NC_007384.1 Code: P; COG: COG2223; nitrite extrusion protein 2056800 narK 3667904 narK Shigella sonnei Ss046 nitrite extrusion protein YP_310855.1 2055409 R 300269 CDS YP_310856.1 74312437 3667905 complement(2056895..2057113) 1 NC_007384.1 hypothetical protein 2057113 3667905 SSON_1954 Shigella sonnei Ss046 hypothetical protein YP_310856.1 2056895 R 300269 CDS YP_310857.1 74312438 3667906 2057139..2058935 1 NC_007384.1 Code: T; COG: COG3850; nitrate/nitrite sensor protein NarX 2058935 narX 3667906 narX Shigella sonnei Ss046 nitrate/nitrite sensor protein NarX YP_310857.1 2057139 D 300269 CDS YP_310858.1 74312439 3667907 2058928..2059578 1 NC_007384.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL 2059578 narL 3667907 narL Shigella sonnei Ss046 transcriptional regulator NarL YP_310858.1 2058928 D 300269 CDS YP_310859.1 74312440 3667908 complement(2059579..2060832) 1 NC_007384.1 hypothetical protein 2060832 ychP 3667908 ychP Shigella sonnei Ss046 hypothetical protein YP_310859.1 2059579 R 300269 CDS YP_310860.1 74312441 3667909 2061158..2061511 1 NC_007384.1 Code: P; COG: COG1553; hypothetical protein 2061511 ychN 3667909 ychN Shigella sonnei Ss046 hypothetical protein YP_310860.1 2061158 D 300269 CDS YP_310861.1 74312442 3667910 complement(2061555..2062271) 1 NC_007384.1 Code: P; COG: COG3703; cation transport regulator 2062271 chaC 3667910 chaC Shigella sonnei Ss046 cation transport regulator YP_310861.1 2061555 R 300269 CDS YP_310862.1 74312443 3667911 complement(2062408..2062638) 1 NC_007384.1 in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 2062638 chaB 3667911 chaB Shigella sonnei Ss046 cation transport regulator YP_310862.1 2062408 R 300269 CDS YP_310863.1 74312444 3667912 2062908..2064008 1 NC_007384.1 Code: P; COG: COG0387; calcium/sodium:proton antiporter 2064008 chaA 3667912 chaA Shigella sonnei Ss046 calcium/sodium:proton antiporter YP_310863.1 2062908 D 300269 CDS YP_310864.1 74312445 3667913 2065455..2065589 1 NC_007384.1 hypothetical protein 2065589 3667913 SSON_1962 Shigella sonnei Ss046 hypothetical protein YP_310864.1 2065455 D 300269 CDS YP_310865.1 74312446 3667914 complement(2065738..2066592) 1 NC_007384.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 2066592 kdsA 3667914 kdsA Shigella sonnei Ss046 2-dehydro-3-deoxyphosphooctonate aldolase YP_310865.1 2065738 R 300269 CDS YP_310866.1 74312447 3667916 complement(2067440..2067832) 1 NC_007384.1 Code: S; COG: COG3094; transcriptional regulator 2067832 3667916 SSON_1965 Shigella sonnei Ss046 transcriptional regulator YP_310866.1 2067440 R 300269 CDS YP_310867.1 74312448 3667917 complement(2067829..2068662) 1 NC_007384.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 2068662 hemK 3667917 hemK Shigella sonnei Ss046 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_310867.1 2067829 R 300269 CDS YP_310868.1 74312449 3667918 complement(2068662..2069744) 1 NC_007384.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 2069744 prfA 3667918 prfA Shigella sonnei Ss046 peptide chain release factor 1 YP_310868.1 2068662 R 300269 CDS YP_310869.1 74312450 3667919 complement(2069786..2071042) 1 NC_007384.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 2071042 hemA 3667919 hemA Shigella sonnei Ss046 glutamyl-tRNA reductase YP_310869.1 2069786 R 300269 CDS YP_310870.1 74312451 3670714 2071256..2071879 1 NC_007384.1 an enzyme in main pathway of synthesis of 5-aminolevulinate, possibly glutamyl-tRNA dehydrogenase; Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; molecular chaperone LolB 2071879 lolB 3670714 lolB Shigella sonnei Ss046 molecular chaperone LolB YP_310870.1 2071256 D 300269 CDS YP_310871.1 74312452 3670715 2071879..2072730 1 NC_007384.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 2072730 ipk 3670715 ipk Shigella sonnei Ss046 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_310871.1 2071879 D 300269 CDS YP_310872.1 74312453 3670716 2072881..2073828 1 NC_007384.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 2073828 prsA 3670716 prsA Shigella sonnei Ss046 ribose-phosphate pyrophosphokinase YP_310872.1 2072881 D 300269 CDS YP_310873.1 74312454 3670717 2073979..2075631 1 NC_007384.1 role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; sulfate transporter YchM 2075631 ychM 3670717 ychM Shigella sonnei Ss046 sulfate transporter YchM YP_310873.1 2073979 D 300269 CDS YP_310874.1 74312455 3670718 complement(2075686..2075964) 1 NC_007384.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 2075964 ychH 3670718 ychH Shigella sonnei Ss046 hypothetical protein YP_310874.1 2075686 R 300269 CDS YP_310875.1 74312456 3670719 2076241..2076825 1 NC_007384.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 2076825 pth 3670719 pth Shigella sonnei Ss046 peptidyl-tRNA hydrolase YP_310875.1 2076241 D 300269 CDS YP_310876.1 74312457 3670720 2076942..2078033 1 NC_007384.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 2078033 ychF 3670720 ychF Shigella sonnei Ss046 GTP-dependent nucleic acid-binding protein EngD YP_310876.1 2076942 D 300269 CDS YP_310877.1 74312458 3670721 complement(2078327..2078530) 1 NC_007384.1 hypothetical protein 2078530 3670721 SSON_1976 Shigella sonnei Ss046 hypothetical protein YP_310877.1 2078327 R 300269 CDS YP_310878.1 74312459 3670722 2079184..2079687 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2079687 3670722 SSON_1977 Shigella sonnei Ss046 IS1 ORF YP_310878.1 2079184 D 300269 CDS YP_310879.1 74312460 3670723 complement(2079751..2080464) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 2080464 3670723 SSON_1978 Shigella sonnei Ss046 IS600 ORF2 YP_310879.1 2079751 R 300269 CDS YP_310880.1 74312461 3670724 complement(2080605..2080907) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 2080907 3670724 SSON_1979 Shigella sonnei Ss046 IS600 ORF1 YP_310880.1 2080605 R 300269 CDS YP_310881.1 74312462 3670725 2081218..2081496 1 NC_007384.1 hypothetical protein 2081496 3670725 SSON_1980 Shigella sonnei Ss046 hypothetical protein YP_310881.1 2081218 D 300269 CDS YP_310882.1 74312463 3670726 2081511..2081921 1 NC_007384.1 has RflA activity; flagellin specific chaperone; flagellar protein FliS 2081921 fliS 3670726 fliS Shigella sonnei Ss046 flagellar protein FliS YP_310882.1 2081511 D 300269 CDS YP_310883.1 74312464 3670727 2081921..2082286 1 NC_007384.1 has RflA activity; binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT 2082286 fliT 3670727 fliT Shigella sonnei Ss046 flagellar biosynthesis protein FliT YP_310883.1 2081921 D 300269 CDS YP_310884.1 74312465 3670728 2082364..2083851 1 NC_007384.1 converts 1,4-alpha-D-glucans to maltodextrin; alpha-amylase 2083851 amyA 3670728 amyA Shigella sonnei Ss046 alpha-amylase YP_310884.1 2082364 D 300269 CDS YP_310885.1 74312466 3670729 complement(2083885..2084298) 1 NC_007384.1 hypothetical protein 2084298 yedD 3670729 yedD Shigella sonnei Ss046 hypothetical protein YP_310885.1 2083885 R 300269 CDS YP_310886.1 74312467 3670730 2084485..2085690 1 NC_007384.1 Code: R; COG: COG2391; inner membrane protein 2085690 yedE 3670730 yedE Shigella sonnei Ss046 inner membrane protein YP_310886.1 2084485 D 300269 CDS YP_310887.1 74312468 3670731 2085687..2085920 1 NC_007384.1 Code: O; COG: COG0425; hypothetical protein 2085920 yedF 3670731 yedF Shigella sonnei Ss046 hypothetical protein YP_310887.1 2085687 D 300269 CDS YP_310888.1 74312469 3670732 2086027..2086698 1 NC_007384.1 Code: S; COG: COG2135; hypothetical protein 2086698 yedK 3670732 yedK Shigella sonnei Ss046 hypothetical protein YP_310888.1 2086027 D 300269 CDS YP_310889.1 74312470 3667044 complement(2086738..2087886) 1 NC_007384.1 Code: L; COG: COG0675; virulence protein 2087886 3667044 SSON_1988 Shigella sonnei Ss046 virulence protein YP_310889.1 2086738 R 300269 CDS YP_310890.1 74312471 3667045 complement(2088805..2089308) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2089308 3667045 SSON_1989 Shigella sonnei Ss046 IS1 ORF YP_310890.1 2088805 R 300269 CDS YP_310891.1 74312472 3667046 2089704..2090069 1 NC_007384.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 2090069 3667046 SSON_1990 Shigella sonnei Ss046 insertion sequence 2 OrfA protein YP_310891.1 2089704 D 300269 CDS YP_310892.2 161986518 3667047 2090027..2090932 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2090932 3667047 SSON_1991 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_310892.2 2090027 D 300269 CDS YP_310893.1 74312474 3667048 complement(2091452..2092249) 1 NC_007384.1 Code: K; COG: COG2207; AraC family transcriptional regulator 2092249 ybcM 3667048 ybcM Shigella sonnei Ss046 AraC family transcriptional regulator YP_310893.1 2091452 R 300269 CDS YP_310894.1 74312475 3667049 complement(2092259..2092810) 1 NC_007384.1 DLP12 prophage; similar to PEBP/RK1P protein family in eukaryotes that inhibits MEK phosphorylation by Raf-1; crystal structure suggests similar properties but exact function is unknown; kinase inhibitor 2092810 ybcL 3667049 ybcL Shigella sonnei Ss046 kinase inhibitor YP_310894.1 2092259 R 300269 CDS YP_310895.1 74312476 3667050 complement(2092979..2093311) 1 NC_007384.1 member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation; multidrug efflux protein 2093311 emrE 3667050 emrE Shigella sonnei Ss046 multidrug efflux protein YP_310895.1 2092979 R 300269 CDS YP_310896.1 74312477 3667051 complement(2093645..2093959) 1 NC_007384.1 possibly at (MS-ring)-rod junction; forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE 2093959 fliE 3667051 fliE Shigella sonnei Ss046 flagellar hook-basal body protein FliE YP_310896.1 2093645 R 300269 CDS YP_310897.1 74312478 3667052 2094175..2095833 1 NC_007384.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein 2095833 fliF 3667052 fliF Shigella sonnei Ss046 flagellar MS-ring protein YP_310897.1 2094175 D 300269 CDS YP_310898.1 74312479 3667053 2095826..2096821 1 NC_007384.1 flagellar biosynthesis; component of motor switching and energizing; enabling rotation and determining its direction; One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 2096821 fliG 3667053 fliG Shigella sonnei Ss046 flagellar motor switch protein G YP_310898.1 2095826 D 300269 CDS YP_310899.2 161986517 3667054 2096814..2097500 1 NC_007384.1 possibly involved in export of flagellar proteins; binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 2097500 fliH 3667054 fliH Shigella sonnei Ss046 flagellar assembly protein H YP_310899.2 2096814 D 300269 CDS YP_310900.1 74312481 3667055 2097500..2098873 1 NC_007384.1 involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 2098873 fliI 3667055 fliI Shigella sonnei Ss046 flagellum-specific ATP synthase YP_310900.1 2097500 D 300269 CDS YP_310901.1 74312482 3667056 2098892..2099335 1 NC_007384.1 rod/hook and filament chaperone; flagellar biosynthesis chaperone 2099335 fliJ 3667056 fliJ Shigella sonnei Ss046 flagellar biosynthesis chaperone YP_310901.1 2098892 D 300269 CDS YP_310902.1 74312483 3667057 2099332..2100459 1 NC_007384.1 Code: N; COG: COG3144; flagellar hook-length control protein 2100459 fliK 3667057 fliK Shigella sonnei Ss046 flagellar hook-length control protein YP_310902.1 2099332 D 300269 CDS YP_310903.1 74312484 3667058 2100564..2101028 1 NC_007384.1 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body protein FliL 2101028 fliL 3667058 fliL Shigella sonnei Ss046 flagellar basal body protein FliL YP_310903.1 2100564 D 300269 CDS YP_310904.1 74312485 3667059 2101033..2102037 1 NC_007384.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 2102037 fliM 3667059 fliM Shigella sonnei Ss046 flagellar motor switch protein FliM YP_310904.1 2101033 D 300269 CDS YP_310905.1 74312486 3667060 2102034..2102447 1 NC_007384.1 flagellar biosynthesis, component of motor switch and energizing, enabling rotation and determining its direction; One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN 2102447 fliN 3667060 fliN Shigella sonnei Ss046 flagellar motor switch protein FliN YP_310905.1 2102034 D 300269 CDS YP_310906.1 74312487 3667061 2102450..2102815 1 NC_007384.1 with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO 2102815 fliO 3667061 fliO Shigella sonnei Ss046 flagellar biosynthesis protein FliO YP_310906.1 2102450 D 300269 CDS YP_310907.1 74312488 3667062 2102815..2103552 1 NC_007384.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 2103552 fliP 3667062 fliP Shigella sonnei Ss046 flagellar biosynthesis protein FliP YP_310907.1 2102815 D 300269 CDS YP_310908.1 74312489 3667063 2103562..2103831 1 NC_007384.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ 2103831 fliQ 3667063 fliQ Shigella sonnei Ss046 flagellar biosynthesis protein FliQ YP_310908.1 2103562 D 300269 CDS YP_310909.1 74312490 3667006 2103840..2104625 1 NC_007384.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR 2104625 fliR 3667006 fliR Shigella sonnei Ss046 flagellar biosynthesis protein FliR YP_310909.1 2103840 D 300269 CDS YP_310910.1 74312491 3667007 2104910..2105533 1 NC_007384.1 positive transcription factor; Code: K; COG: COG2771; positive regulator for ctr capsule biosynthesis 2105533 rcsA 3667007 rcsA Shigella sonnei Ss046 positive regulator for ctr capsule biosynthesis YP_310910.1 2104910 D 300269 CDS YP_310911.1 74312492 3667008 complement(2105577..2105765) 1 NC_007384.1 hypothetical protein 2105765 dsrB 3667008 dsrB Shigella sonnei Ss046 hypothetical protein YP_310911.1 2105577 R 300269 CDS YP_310912.1 74312493 3667009 2105913..2106155 1 NC_007384.1 hypothetical protein 2106155 3667009 SSON_2011 Shigella sonnei Ss046 hypothetical protein YP_310912.1 2105913 D 300269 CDS YP_310913.1 74312494 3667010 2106453..2107268 1 NC_007384.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate; mannosyl-3-phosphoglycerate phosphatase 2107268 3667010 SSON_2012 Shigella sonnei Ss046 mannosyl-3-phosphoglycerate phosphatase YP_310913.1 2106453 D 300269 CDS YP_310914.1 74312495 3667011 complement(2107265..2108974) 1 NC_007384.1 Code: T; COG: COG2199; hypothetical protein 2108974 3667011 SSON_2013 Shigella sonnei Ss046 hypothetical protein YP_310914.1 2107265 R 300269 CDS YP_310915.1 74312496 3667012 complement(2109130..2109312) 1 NC_007384.1 Code: S; COG: COG5475; hypothetical protein 2109312 3667012 SSON_2014 Shigella sonnei Ss046 hypothetical protein YP_310915.1 2109130 R 300269 CDS YP_310916.1 74312497 3667013 complement(2109391..2110308) 1 NC_007384.1 Code: S; COG: COG2354; hypothetical protein 2110308 yedI 3667013 yedI Shigella sonnei Ss046 hypothetical protein YP_310916.1 2109391 R 300269 CDS YP_310917.1 74312498 3667015 complement(2111391..2111861) 1 NC_007384.1 patch repair protein; Code: L; COG: COG3727; DNA mismatch endonuclease 2111861 vsr 3667015 vsr Shigella sonnei Ss046 DNA mismatch endonuclease YP_310917.1 2111391 R 300269 CDS YP_310918.1 74312499 3667016 complement(2111842..2113260) 1 NC_007384.1 Code: L; COG: COG0270; DNA cytosine methylase 2113260 dcm 3667016 dcm Shigella sonnei Ss046 DNA cytosine methylase YP_310918.1 2111842 R 300269 CDS YP_310919.1 74312500 3667017 complement(2113327..2113983) 1 NC_007384.1 Code: R; COG: COG1418; hypothetical protein 2113983 yedJ 3667017 yedJ Shigella sonnei Ss046 hypothetical protein YP_310919.1 2113327 R 300269 CDS YP_310920.1 74312501 3667018 complement(2114023..2114406) 1 NC_007384.1 hypothetical protein 2114406 3667018 SSON_2020 Shigella sonnei Ss046 hypothetical protein YP_310920.1 2114023 R 300269 CDS YP_310921.1 74312502 3667020 2116005..2116508 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2116508 3667020 SSON_2022 Shigella sonnei Ss046 IS1 ORF YP_310921.1 2116005 D 300269 CDS YP_310922.1 74312503 3667021 2117486..2118337 1 NC_007384.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 2118337 yedU 3667021 yedU Shigella sonnei Ss046 chaperone protein HchA YP_310922.1 2117486 D 300269 CDS YP_310923.1 74312504 3667022 2118353..2118631 1 NC_007384.1 Code: L; COG: COG2963; IS2 orf1 2118631 3667022 SSON_2024 Shigella sonnei Ss046 IS2 orf1 YP_310923.1 2118353 D 300269 CDS YP_310924.2 161986516 3667023 2118589..2119494 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2119494 3667023 SSON_2025 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_310924.2 2118589 D 300269 CDS YP_310925.1 74312506 3667024 complement(2119522..2120880) 1 NC_007384.1 Code: T; COG: COG0642; 2-component sensor protein 2120880 yedV 3667024 yedV Shigella sonnei Ss046 2-component sensor protein YP_310925.1 2119522 R 300269 CDS YP_310926.2 161986515 3666820 complement(2120880..2121551) 1 NC_007384.1 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW 2121551 yedW 3666820 yedW Shigella sonnei Ss046 transcriptional regulatory protein YedW YP_310926.2 2120880 R 300269 CDS YP_310927.2 161986514 3666821 2122002..2122907 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2122907 3666821 SSON_2028 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_310927.2 2122002 D 300269 CDS YP_310928.1 74312509 3666822 2123020..2123433 1 NC_007384.1 Code: R; COG: COG2351; hypothetical protein 2123433 yedX 3666822 yedX Shigella sonnei Ss046 hypothetical protein YP_310928.1 2123020 D 300269 CDS YP_310929.1 74312510 3666823 2123542..2124546 1 NC_007384.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; sulfite oxidase subunit YedY 2124546 3666823 SSON_2030 Shigella sonnei Ss046 sulfite oxidase subunit YedY YP_310929.1 2123542 D 300269 CDS YP_310930.1 74312511 3666824 2124547..2125182 1 NC_007384.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; sulfite oxidase subunit YedZ 2125182 3666824 SSON_2031 Shigella sonnei Ss046 sulfite oxidase subunit YedZ YP_310930.1 2124547 D 300269 CDS YP_310931.1 74312512 3666825 2125439..2126089 1 NC_007384.1 Code: R; COG: COG3443; hypothetical protein 2126089 3666825 SSON_2032 Shigella sonnei Ss046 hypothetical protein YP_310931.1 2125439 D 300269 CDS YP_310932.1 74312513 3666828 2127676..2128512 1 NC_007384.1 Code: S; COG: COG3228; hypothetical protein 2128512 3666828 SSON_2035 Shigella sonnei Ss046 hypothetical protein YP_310932.1 2127676 D 300269 CDS YP_310933.1 74312514 3666831 complement(2134963..2135802) 1 NC_007384.1 Code: L; COG: COG2801; IS911 ORF2 2135802 3666831 SSON_2038 Shigella sonnei Ss046 IS911 ORF2 YP_310933.1 2134963 R 300269 CDS YP_310934.1 74312515 3666832 2137314..2138345 1 NC_007384.1 Code: L; COG: COG3335; IS630 orf 2138345 3666832 SSON_2039 Shigella sonnei Ss046 IS630 orf YP_310934.1 2137314 D 300269 CDS YP_310935.1 74312516 3666833 complement(2138736..2139062) 1 NC_007384.1 Code: M; COG: COG0859; hypothetical protein 2139062 3666833 SSON_2040 Shigella sonnei Ss046 hypothetical protein YP_310935.1 2138736 R 300269 CDS YP_310936.1 74312517 3666834 2141363..2141866 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2141866 3666834 SSON_2041 Shigella sonnei Ss046 IS1 ORF YP_310936.1 2141363 D 300269 CDS YP_310937.1 74312518 3666835 2142001..2142951 1 NC_007384.1 LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl 2142951 cbl 3666835 cbl Shigella sonnei Ss046 transcriptional regulator Cbl YP_310937.1 2142001 D 300269 CDS YP_310938.1 74312519 3666729 2143072..2144712 1 NC_007384.1 Code: V; COG: COG0534; hypothetical protein 2144712 yeeO 3666729 yeeO Shigella sonnei Ss046 hypothetical protein YP_310938.1 2143072 D 300269 CDS YP_310939.1 74312520 3666731 complement(2145341..2146057) 1 NC_007384.1 Code: S; COG: COG0217; hypothetical protein 2146057 3666731 SSON_2046 Shigella sonnei Ss046 hypothetical protein YP_310939.1 2145341 R 300269 CDS YP_310940.1 74312521 3666732 complement(2146388..2147842) 1 NC_007384.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 2147842 amn 3666732 amn Shigella sonnei Ss046 AMP nucleosidase YP_310940.1 2146388 R 300269 CDS YP_310941.1 74312522 3666733 complement(2148274..2148777) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2148777 3666733 SSON_2048 Shigella sonnei Ss046 IS1 ORF YP_310941.1 2148274 R 300269 CDS YP_310942.1 74312523 3666734 complement(2149000..2149935) 1 NC_007384.1 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator 2149935 nac 3666734 nac Shigella sonnei Ss046 nitrogen assimilation transcriptional regulator YP_310942.1 2149000 R 300269 CDS YP_310943.1 74312524 3666737 complement(2151391..2152470) 1 NC_007384.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 2152470 cobT 3666737 cobT Shigella sonnei Ss046 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase YP_310943.1 2151391 R 300269 CDS YP_310944.1 74312525 3666738 complement(2152482..2153225) 1 NC_007384.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 2153225 cobS 3666738 cobS Shigella sonnei Ss046 cobalamin synthase YP_310944.1 2152482 R 300269 CDS YP_310945.1 74312526 3666739 complement(2153222..2153767) 1 NC_007384.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase 2153767 cobU 3666739 cobU Shigella sonnei Ss046 adenosylcobinamide kinase YP_310945.1 2153222 R 300269 CDS YP_310946.1 74312527 3666740 complement(2153901..2154398) 1 NC_007384.1 hypothetical protein 2154398 3666740 SSON_2055 Shigella sonnei Ss046 hypothetical protein YP_310946.1 2153901 R 300269 CDS YP_310947.1 74312528 3666741 complement(2154849..2155496) 1 NC_007384.1 Code: TK; COG: COG4936; pdu/cob regulatory protein 2155496 pocR 3666741 pocR Shigella sonnei Ss046 pdu/cob regulatory protein YP_310947.1 2154849 R 300269 CDS YP_310948.1 74312529 3666742 complement(2155699..2156508) 1 NC_007384.1 Code: G; COG: COG0580; propanediol diffusion facilitator 2156508 pduF 3666742 pduF Shigella sonnei Ss046 propanediol diffusion facilitator YP_310948.1 2155699 R 300269 CDS YP_310949.1 74312530 3666743 2157020..2157304 1 NC_007384.1 Code: QC; COG: COG4577; propanediol utilization polyhedral bodies protein 2157304 pduA 3666743 pduA Shigella sonnei Ss046 propanediol utilization polyhedral bodies protein YP_310949.1 2157020 D 300269 CDS YP_310950.1 74312531 3666744 2157301..2158113 1 NC_007384.1 Code: E; COG: COG4816; propanediol utilization polyhedral bodies protein 2158113 pduB 3666744 pduB Shigella sonnei Ss046 propanediol utilization polyhedral bodies protein YP_310950.1 2157301 D 300269 CDS YP_310951.1 74312532 3666745 2158132..2159796 1 NC_007384.1 Code: Q; COG: COG4909; propanediol utilization glycerol dehydratase large subunit 2159796 pduC 3666745 pduC Shigella sonnei Ss046 propanediol utilization glycerol dehydratase large subunit YP_310951.1 2158132 D 300269 CDS YP_310952.1 74312533 3666385 2159806..2160474 1 NC_007384.1 propanediol utilization diol dehydratase medium subunit 2160474 pduD 3666385 pduD Shigella sonnei Ss046 propanediol utilization diol dehydratase medium subunit YP_310952.1 2159806 D 300269 CDS YP_310953.1 74312534 3666386 2160489..2161007 1 NC_007384.1 Code: Q; COG: COG4910; propanediol utilization diol dehydratase small subunit 2161007 pduE 3666386 pduE Shigella sonnei Ss046 propanediol utilization diol dehydratase small subunit YP_310953.1 2160489 D 300269 CDS YP_310954.1 74312535 3666387 2161017..2162849 1 NC_007384.1 propanediol utilization diol dehydratase reactivation protein 2162849 pduG 3666387 pduG Shigella sonnei Ss046 propanediol utilization diol dehydratase reactivation protein YP_310954.1 2161017 D 300269 CDS YP_310955.1 74312536 3666388 2162839..2163189 1 NC_007384.1 propanediol utilization diol dehydratase reactivation protein 2163189 pduH 3666388 pduH Shigella sonnei Ss046 propanediol utilization diol dehydratase reactivation protein YP_310955.1 2162839 D 300269 CDS YP_310956.1 74312537 3666389 2163209..2163484 1 NC_007384.1 Code: QC; COG: COG4577; propanediol utilization polyhedral bodies protein 2163484 pduJ 3666389 pduJ Shigella sonnei Ss046 propanediol utilization polyhedral bodies protein YP_310956.1 2163209 D 300269 CDS YP_310957.1 74312538 3666390 2163508..2163930 1 NC_007384.1 Code: QC; COG: COG4577; propanediol utilization polyhedral bodies protein 2163930 pduK 3666390 pduK Shigella sonnei Ss046 propanediol utilization polyhedral bodies protein YP_310957.1 2163508 D 300269 CDS YP_310958.1 74312539 3666391 2163933..2164565 1 NC_007384.1 Code: Q; COG: COG4869; propanediol utilization protein 2164565 pduL 3666391 pduL Shigella sonnei Ss046 propanediol utilization protein YP_310958.1 2163933 D 300269 CDS YP_310959.1 74312540 3666392 2164562..2165053 1 NC_007384.1 propanediol utilization protein 2165053 pduM 3666392 pduM Shigella sonnei Ss046 propanediol utilization protein YP_310959.1 2164562 D 300269 CDS YP_310960.1 74312541 3666393 2165057..2165332 1 NC_007384.1 Code: QC; COG: COG4576; propanediol utilization polyhedral bodies protein 2165332 pduN 3666393 pduN Shigella sonnei Ss046 propanediol utilization polyhedral bodies protein YP_310960.1 2165057 D 300269 CDS YP_310961.1 74312542 3666394 2165344..2166351 1 NC_007384.1 Code: S; COG: COG2096; propanediol utilization B12 -like protein 2166351 pduO 3666394 pduO Shigella sonnei Ss046 propanediol utilization B12 -like protein YP_310961.1 2165344 D 300269 CDS YP_310962.1 74312543 3666395 2166549..2167733 1 NC_007384.1 Code: C; COG: COG1012; propanediol utilization CoA-dependent propionaldehyde dehydrogenase 2167733 pduP 3666395 pduP Shigella sonnei Ss046 propanediol utilization CoA-dependent propionaldehyde dehydrogenase YP_310962.1 2166549 D 300269 CDS YP_310963.1 74312544 3666396 2167744..2168856 1 NC_007384.1 Code: C; COG: COG1454; propanediol utilization propanol dehydrogenase 2168856 pduQ 3666396 pduQ Shigella sonnei Ss046 propanediol utilization propanol dehydrogenase YP_310963.1 2167744 D 300269 CDS YP_310964.1 74312545 3666397 2168853..2169755 1 NC_007384.1 Code: C; COG: COG4656; propanediol utilization ferredoxin 2169755 pduS 3666397 pduS Shigella sonnei Ss046 propanediol utilization ferredoxin YP_310964.1 2168853 D 300269 CDS YP_310965.1 74312546 3666398 2170201..2170755 1 NC_007384.1 Code: QC; COG: COG4577; propanediol utilization polyhedral bodies protein 2170755 pduT 3666398 pduT Shigella sonnei Ss046 propanediol utilization polyhedral bodies protein YP_310965.1 2170201 D 300269 CDS YP_310966.1 74312547 3666399 2170755..2171105 1 NC_007384.1 Code: E; COG: COG4810; propanediol utilization polyhedral bodies protein 2171105 pduU 3666399 pduU Shigella sonnei Ss046 propanediol utilization polyhedral bodies protein YP_310966.1 2170755 D 300269 CDS YP_310967.1 74312548 3666400 2171110..2171553 1 NC_007384.1 Code: E; COG: COG4917; propanediol utilization protein 2171553 pduV 3666400 pduV Shigella sonnei Ss046 propanediol utilization protein YP_310967.1 2171110 D 300269 CDS YP_310968.1 74312549 3666401 complement(2171654..2172049) 1 NC_007384.1 Code: S; COG: COG2926; hypothetical protein 2172049 yeeX 3666401 yeeX Shigella sonnei Ss046 hypothetical protein YP_310968.1 2171654 R 300269 CDS YP_310969.1 74312550 3666402 complement(2172155..2173213) 1 NC_007384.1 Code: S; COG: COG1289; hypothetical protein 2173213 yeeA 3666402 yeeA Shigella sonnei Ss046 hypothetical protein YP_310969.1 2172155 R 300269 CDS YP_310970.1 74312551 3666403 complement(2173411..2173884) 1 NC_007384.1 Code: L; COG: COG3449; DNA gyrase inhibitor 2173884 sbmC 3666403 sbmC Shigella sonnei Ss046 DNA gyrase inhibitor YP_310970.1 2173411 R 300269 CDS YP_310971.1 74312552 3666691 complement(2174003..2175175) 1 NC_007384.1 removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 2175175 dacD 3666691 dacD Shigella sonnei Ss046 D-alanyl-D-alanine carboxypeptidase YP_310971.1 2174003 R 300269 CDS YP_310972.1 74312553 3666692 2175378..2176805 1 NC_007384.1 exonuclease I, 3' --> 5' specific; Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 2176805 sbcB 3666692 sbcB Shigella sonnei Ss046 exonuclease I YP_310972.1 2175378 D 300269 CDS YP_310973.1 74312554 3666693 complement(2176848..2177075) 1 NC_007384.1 Code: O; COG: COG0425; hypothetical protein 2177075 yeeD 3666693 yeeD Shigella sonnei Ss046 hypothetical protein YP_310973.1 2176848 R 300269 CDS YP_310974.1 74312555 3666694 complement(2177089..2178147) 1 NC_007384.1 Code: R; COG: COG2391; transport system permease 2178147 yeeE 3666694 yeeE Shigella sonnei Ss046 transport system permease YP_310974.1 2177089 R 300269 CDS YP_310975.1 74312556 3666695 complement(2178326..2179690) 1 NC_007384.1 Code: E; COG: COG0531; amino acid/amine transport protein 2179690 yeeF 3666695 yeeF Shigella sonnei Ss046 amino acid/amine transport protein YP_310975.1 2178326 R 300269 CDS YP_310976.1 74312557 3666696 complement(2179951..2180901) 1 NC_007384.1 Code: K; COG: COG0583; LysR family transcriptional regulator 2180901 yeeY 3666696 yeeY Shigella sonnei Ss046 LysR family transcriptional regulator YP_310976.1 2179951 R 300269 CDS YP_310977.1 74312558 3666697 complement(2180926..2181750) 1 NC_007384.1 Code: MG; COG: COG0451; sugar metabolism protein 2181750 3666697 SSON_2086 Shigella sonnei Ss046 sugar metabolism protein YP_310977.1 2180926 R 300269 CDS YP_310978.1 74312559 3666698 complement(2181833..2182087) 1 NC_007384.1 Code: S; COG: COG4115; hypothetical protein 2182087 3666698 SSON_2087 Shigella sonnei Ss046 hypothetical protein YP_310978.1 2181833 R 300269 CDS YP_310979.1 74312560 3666699 complement(2182084..2182335) 1 NC_007384.1 Antitoxin that counteracts the effect of the YoeB toxin; antitoxin YefM 2182335 yefM 3666699 yefM Shigella sonnei Ss046 antitoxin YefM YP_310979.1 2182084 R 300269 CDS YP_310981.1 74312562 3666701 2182814..2183713 1 NC_007384.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2183713 hisG 3666701 hisG Shigella sonnei Ss046 ATP phosphoribosyltransferase YP_310981.1 2182814 D 300269 CDS YP_310982.1 74312563 3666702 2183719..2185023 1 NC_007384.1 L-histidinol:NAD+ oxidoreductase; catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2185023 hisD 3666702 hisD Shigella sonnei Ss046 histidinol dehydrogenase YP_310982.1 2183719 D 300269 CDS YP_310983.1 74312564 3666703 2185020..2186090 1 NC_007384.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2186090 hisC 3666703 hisC Shigella sonnei Ss046 histidinol-phosphate aminotransferase YP_310983.1 2185020 D 300269 CDS YP_310984.2 161986513 3666704 2186090..2187157 1 NC_007384.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2187157 hisB 3666704 hisB Shigella sonnei Ss046 imidazole glycerol-phosphate dehydratase/histidinol phosphatase YP_310984.2 2186090 D 300269 CDS YP_310985.1 74312566 3666705 2187157..2187747 1 NC_007384.1 imidazole glycerol phosphate synthase holoenzyme; with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2187747 hisH 3666705 hisH Shigella sonnei Ss046 imidazole glycerol phosphate synthase subunit HisH YP_310985.1 2187157 D 300269 CDS YP_310986.2 161986512 3666706 2187747..2188484 1 NC_007384.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2188484 hisA 3666706 hisA Shigella sonnei Ss046 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase YP_310986.2 2187747 D 300269 CDS YP_310987.1 74312568 3666707 2188466..2189242 1 NC_007384.1 imidazole glycerol phsphate synthase holoenzyme; catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2189242 hisF 3666707 hisF Shigella sonnei Ss046 imidazole glycerol phosphate synthase subunit HisF YP_310987.1 2188466 D 300269 CDS YP_310988.1 74312569 3666708 2189236..2189847 1 NC_007384.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase 2189847 hisI 3666708 hisI Shigella sonnei Ss046 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase YP_310988.1 2189236 D 300269 CDS YP_310989.1 74312570 3666709 complement(2189944..2190957) 1 NC_007384.1 Code: M; COG: COG3765; regulator of length of O-antigen component of lipopolysaccharide chains 2190957 wzzB 3666709 wzzB Shigella sonnei Ss046 regulator of length of O-antigen component of lipopolysaccharide chains YP_310989.1 2189944 R 300269 CDS YP_310990.1 74312571 3666710 complement(2191067..2192233) 1 NC_007384.1 Code: M; COG: COG1004; UDP-glucose 6-dehydrogenase 2192233 ugd 3666710 ugd Shigella sonnei Ss046 UDP-glucose 6-dehydrogenase YP_310990.1 2191067 R 300269 CDS YP_310991.1 74312572 3666785 complement(2192483..2193889) 1 NC_007384.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 2193889 gnd 3666785 gnd Shigella sonnei Ss046 6-phosphogluconate dehydrogenase YP_310991.1 2192483 R 300269 CDS YP_310992.1 74312573 3666786 complement(2194053..2195423) 1 NC_007384.1 Code: G; COG: COG1109; phosphomannomutase 2195423 cpsG 3666786 cpsG Shigella sonnei Ss046 phosphomannomutase YP_310992.1 2194053 R 300269 CDS YP_310993.1 74312574 3666787 complement(2195528..2196964) 1 NC_007384.1 Code: M; COG: COG0836; mannose-1-phosphate guanylyltransferase 2196964 cpsB 3666787 cpsB Shigella sonnei Ss046 mannose-1-phosphate guanylyltransferase YP_310993.1 2195528 R 300269 CDS YP_310994.1 74312575 3666788 complement(2196967..2198190) 1 NC_007384.1 Code: M; COG: COG0438; glycosyl transferase family protein 2198190 wcaI 3666788 wcaI Shigella sonnei Ss046 glycosyl transferase family protein YP_310994.1 2196967 R 300269 CDS YP_310995.1 74312576 3666789 complement(2198187..2198669) 1 NC_007384.1 Code: LR; COG: COG0494; GDP-mannose mannosyl hydrolase 2198669 wcaH 3666789 wcaH Shigella sonnei Ss046 GDP-mannose mannosyl hydrolase YP_310995.1 2198187 R 300269 CDS YP_310996.1 74312577 3666790 complement(2198669..2199634) 1 NC_007384.1 Code: MG; COG: COG0451; nucleotide di-P-sugar epimerase or dehydratase 2199634 wcaG 3666790 wcaG Shigella sonnei Ss046 nucleotide di-P-sugar epimerase or dehydratase YP_310996.1 2198669 R 300269 CDS YP_310997.1 74312578 3666791 complement(2199637..2200758) 1 NC_007384.1 Code: M; COG: COG1089; GDP-D-mannose dehydratase 2200758 gmd 3666791 gmd Shigella sonnei Ss046 GDP-D-mannose dehydratase YP_310997.1 2199637 R 300269 CDS YP_310998.1 74312579 3666792 complement(2200784..2201332) 1 NC_007384.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); colanic acid biosynthesis acetyltransferase WcaF 2201332 wcaF 3666792 wcaF Shigella sonnei Ss046 colanic acid biosynthesis acetyltransferase WcaF YP_310998.1 2200784 R 300269 CDS YP_310999.1 74312580 3666793 complement(2201348..2202094) 1 NC_007384.1 Code: M; COG: COG0463; glycosyl transferase family protein 2202094 wcaE 3666793 wcaE Shigella sonnei Ss046 glycosyl transferase family protein YP_310999.1 2201348 R 300269 CDS YP_311000.1 74312581 3666794 complement(2202105..2203322) 1 NC_007384.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance; colanic acid biosynthesis protein 2203322 wcaD 3666794 wcaD Shigella sonnei Ss046 colanic acid biosynthesis protein YP_311000.1 2202105 R 300269 CDS YP_311001.1 74312582 3666795 complement(2203297..2204514) 1 NC_007384.1 Code: M; COG: COG0438; glycosyl transferase family protein 2204514 wcaC 3666795 wcaC Shigella sonnei Ss046 glycosyl transferase family protein YP_311001.1 2203297 R 300269 CDS YP_311002.1 74312583 3666796 complement(2204511..2204999) 1 NC_007384.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; colanic acid biosynthesis acetyltransferase WcaB 2204999 wcaB 3666796 wcaB Shigella sonnei Ss046 colanic acid biosynthesis acetyltransferase WcaB YP_311002.1 2204511 R 300269 CDS YP_311003.1 74312584 3666797 complement(2205002..2205841) 1 NC_007384.1 Code: M; COG: COG0463; glycosyl transferase family protein 2205841 wcaA 3666797 wcaA Shigella sonnei Ss046 glycosyl transferase family protein YP_311003.1 2205002 R 300269 CDS YP_311004.2 161986511 3666798 complement(2205934..2208096) 1 NC_007384.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase 2208096 3666798 SSON_2113 Shigella sonnei Ss046 tyrosine kinase YP_311004.2 2205934 R 300269 CDS YP_311005.1 74312586 3666799 complement(2208099..2208542) 1 NC_007384.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase 2208542 wzb 3666799 wzb Shigella sonnei Ss046 tyrosine phosphatase YP_311005.1 2208099 R 300269 CDS YP_311006.1 74312587 3666800 complement(2208548..2209687) 1 NC_007384.1 Code: M; COG: COG1596; polysaccharide export protein 2209687 wza 3666800 wza Shigella sonnei Ss046 polysaccharide export protein YP_311006.1 2208548 R 300269 CDS YP_311007.1 74312588 3666801 2210280..2211929 1 NC_007384.1 Code: R; COG: COG1253; transporter 2211929 yegH 3666801 yegH Shigella sonnei Ss046 transporter YP_311007.1 2210280 D 300269 CDS YP_311008.1 74312589 3666802 complement(2212191..2214056) 1 NC_007384.1 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; assembly protein 2214056 asmA 3666802 asmA Shigella sonnei Ss046 assembly protein YP_311008.1 2212191 R 300269 CDS YP_311009.1 74312590 3666803 complement(2214078..2214659) 1 NC_007384.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 2214659 dcd 3666803 dcd Shigella sonnei Ss046 deoxycytidine triphosphate deaminase YP_311009.1 2214078 R 300269 CDS YP_311010.2 161986510 3666915 complement(2214751..2215392) 1 NC_007384.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 2215392 udk 3666915 udk Shigella sonnei Ss046 uridine kinase YP_311010.2 2214751 R 300269 CDS YP_311011.1 74312592 3666916 2215710..2219027 1 NC_007384.1 contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction; sensor protein 2219027 yegE 3666916 yegE Shigella sonnei Ss046 sensor protein YP_311011.1 2215710 D 300269 CDS YP_311012.1 74312593 3666917 complement(2219137..2219985) 1 NC_007384.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyladenine DNA glycosylase 2219985 alkA 3666917 alkA Shigella sonnei Ss046 3-methyladenine DNA glycosylase YP_311012.1 2219137 R 300269 CDS YP_311013.2 161986509 3666918 2220119..2221471 1 NC_007384.1 Code: O; COG: COG0443; chaperone 2221471 yegD 3666918 yegD Shigella sonnei Ss046 chaperone YP_311013.2 2220119 D 300269 CDS YP_311014.1 74312595 3666919 complement(2221484..2223424) 1 NC_007384.1 Code: R; COG: COG4248; chaperonin 2223424 3666919 SSON_2123 Shigella sonnei Ss046 chaperonin YP_311014.1 2221484 R 300269 CDS YP_311015.1 74312596 3666920 complement(2223421..2224182) 1 NC_007384.1 hypothetical protein 2224182 3666920 SSON_2124 Shigella sonnei Ss046 hypothetical protein YP_311015.1 2223421 R 300269 CDS YP_311016.1 74312597 3666921 complement(2224179..2224838) 1 NC_007384.1 Code: R; COG: COG4245; hypothetical protein 2224838 3666921 SSON_2125 Shigella sonnei Ss046 hypothetical protein YP_311016.1 2224179 R 300269 CDS YP_311017.2 161986508 3666922 2226053..2227294 1 NC_007384.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtA 2227294 3666922 SSON_2126 Shigella sonnei Ss046 multidrug efflux system subunit MdtA YP_311017.2 2226053 D 300269 CDS YP_311018.1 74312599 3666923 2227294..2230416 1 NC_007384.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtB 2230416 yegN 3666923 yegN Shigella sonnei Ss046 multidrug efflux system subunit MdtB YP_311018.1 2227294 D 300269 CDS YP_311019.1 74312600 3666924 2230417..2233494 1 NC_007384.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC 2233494 yegO 3666924 yegO Shigella sonnei Ss046 multidrug efflux system subunit MdtC YP_311019.1 2230417 D 300269 CDS YP_311020.1 74312601 3666925 2233495..2234910 1 NC_007384.1 Code: GEPR; COG: COG0477; multidrug efflux system protein MdtE 2234910 yegB 3666925 yegB Shigella sonnei Ss046 multidrug efflux system protein MdtE YP_311020.1 2233495 D 300269 CDS YP_311021.1 74312602 3666926 2234907..2236310 1 NC_007384.1 Code: T; COG: COG0642; signal transduction histidine-protein kinase BaeS 2236310 baeS 3666926 baeS Shigella sonnei Ss046 signal transduction histidine-protein kinase BaeS YP_311021.1 2234907 D 300269 CDS YP_311022.1 74312603 3666927 2236307..2237029 1 NC_007384.1 sensor BaeS; response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; DNA-binding transcriptional regulator BaeR 2237029 baeR 3666927 baeR Shigella sonnei Ss046 DNA-binding transcriptional regulator BaeR YP_311022.1 2236307 D 300269 CDS YP_311023.1 74312604 3666928 2237365..2237868 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2237868 3666928 SSON_2132 Shigella sonnei Ss046 IS1 ORF YP_311023.1 2237365 D 300269 CDS YP_311024.1 74312605 3666929 2237958..2238329 1 NC_007384.1 Code: S; COG: COG3422; hypothetical protein 2238329 yegP 3666929 yegP Shigella sonnei Ss046 hypothetical protein YP_311024.1 2237958 D 300269 CDS YP_311025.1 74312606 3666930 2238476..2239837 1 NC_007384.1 Code: O; COG: COG0826; hypothetical protein 2239837 yegQ 3666930 yegQ Shigella sonnei Ss046 hypothetical protein YP_311025.1 2238476 D 300269 CDS YP_311026.1 74312607 3666931 complement(2240167..2240544) 1 NC_007384.1 hypothetical protein 2240544 3666931 SSON_2135 Shigella sonnei Ss046 hypothetical protein YP_311026.1 2240167 R 300269 CDS YP_311027.1 74312608 3666932 2240890..2241789 1 NC_007384.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase 2241789 3666932 SSON_2136 Shigella sonnei Ss046 lipid kinase YP_311027.1 2240890 D 300269 CDS YP_311028.1 74312609 3666933 complement(2241871..2242650) 1 NC_007384.1 Code: KG; COG: COG1349; galactitol utilization operon repressor 2242650 gatR 3666933 gatR Shigella sonnei Ss046 galactitol utilization operon repressor YP_311028.1 2241871 R 300269 CDS YP_311029.1 74312610 3666934 complement(2242750..2243790) 1 NC_007384.1 Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase 2243790 gatD 3666934 gatD Shigella sonnei Ss046 galactitol-1-phosphate dehydrogenase YP_311029.1 2242750 R 300269 CDS YP_311030.1 74312611 3666954 complement(2243838..2245193) 1 NC_007384.1 Code: G; COG: COG3775; PTS system galactitol-specific transporter subunit IIC 2245193 gatC 3666954 gatC Shigella sonnei Ss046 PTS system galactitol-specific transporter subunit IIC YP_311030.1 2243838 R 300269 CDS YP_311031.1 74312612 3666955 complement(2245197..2245481) 1 NC_007384.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIB 2245481 gatB 3666955 gatB Shigella sonnei Ss046 PTS system galactitol-specific transporter subunit IIB YP_311031.1 2245197 R 300269 CDS YP_311032.1 74312613 3666956 complement(2245853..2246356) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2246356 3666956 SSON_2141 Shigella sonnei Ss046 IS1 ORF YP_311032.1 2245853 R 300269 CDS YP_311033.2 161986507 3666959 complement(2248036..2248890) 1 NC_007384.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 2248890 gatY 3666959 gatY Shigella sonnei Ss046 tagatose-bisphosphate aldolase YP_311033.2 2248036 R 300269 CDS YP_311034.2 161986506 3666960 complement(2249209..2250261) 1 NC_007384.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase 2250261 3666960 SSON_2145 Shigella sonnei Ss046 fructose-bisphosphate aldolase YP_311034.2 2249209 R 300269 CDS YP_311035.1 74312616 3666961 2250518..2251795 1 NC_007384.1 Code: GEPR; COG: COG0477; nucleoside permease 2251795 yegT 3666961 yegT Shigella sonnei Ss046 nucleoside permease YP_311035.1 2250518 D 300269 CDS YP_311036.1 74312617 3666962 2251792..2252796 1 NC_007384.1 Code: O; COG: COG1397; hypothetical protein 2252796 3666962 SSON_2147 Shigella sonnei Ss046 hypothetical protein YP_311036.1 2251792 D 300269 CDS YP_311037.1 74312618 3666963 2252793..2253758 1 NC_007384.1 Code: G; COG: COG0524; kinase 2253758 3666963 SSON_2148 Shigella sonnei Ss046 kinase YP_311037.1 2252793 D 300269 CDS YP_311038.1 74312619 3666964 complement(2253732..2254478) 1 NC_007384.1 Code: K; COG: COG2188; transcriptional regulator 2254478 yegW 3666964 yegW Shigella sonnei Ss046 transcriptional regulator YP_311038.1 2253732 R 300269 CDS YP_311039.1 74312620 3666965 complement(2254530..2255357) 1 NC_007384.1 Code: M; COG: COG3757; hypothetical protein 2255357 yegX 3666965 yegX Shigella sonnei Ss046 hypothetical protein YP_311039.1 2254530 R 300269 CDS YP_311040.1 74312621 3666966 complement(2255413..2256213) 1 NC_007384.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 2256213 thiD 3666966 thiD Shigella sonnei Ss046 phosphomethylpyrimidine kinase YP_311040.1 2255413 R 300269 CDS YP_311041.1 74312622 3666967 complement(2256210..2256998) 1 NC_007384.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 2256998 thiM 3666967 thiM Shigella sonnei Ss046 hydroxyethylthiazole kinase YP_311041.1 2256210 R 300269 CDS YP_311042.1 74312623 3666968 complement(2257221..2257493) 1 NC_007384.1 Code: S; COG: COG1937; hypothetical protein 2257493 yohL 3666968 yohL Shigella sonnei Ss046 hypothetical protein YP_311042.1 2257221 R 300269 CDS YP_311043.1 74312624 3666969 2257614..2258438 1 NC_007384.1 membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA 2258438 yohM 3666969 yohM Shigella sonnei Ss046 nickel/cobalt efflux protein RcnA YP_311043.1 2257614 D 300269 CDS YP_311044.1 74312625 3666970 2258477..2258995 1 NC_007384.1 Code: S; COG: COG5455; hypothetical protein 2258995 3666970 SSON_2155 Shigella sonnei Ss046 hypothetical protein YP_311044.1 2258477 D 300269 CDS YP_311045.1 74312626 3666971 complement(2259077..2260111) 1 NC_007384.1 type-1 fimbrial protein 2260111 yehA 3666971 yehA Shigella sonnei Ss046 type-1 fimbrial protein YP_311045.1 2259077 R 300269 CDS YP_311046.1 74312627 3666972 complement(2262212..2262715) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2262715 3666972 SSON_2157 Shigella sonnei Ss046 IS1 ORF YP_311046.1 2262212 R 300269 CDS YP_311047.1 74312628 3667195 complement(2263400..2264119) 1 NC_007384.1 Code: NU; COG: COG3121; chaperone 2264119 yehC 3667195 yehC Shigella sonnei Ss046 chaperone YP_311047.1 2263400 R 300269 CDS YP_311048.1 74312629 3667196 complement(2264154..2264696) 1 NC_007384.1 Code: NU; COG: COG3539; fimbrial-like protein 2264696 yehD 3667196 yehD Shigella sonnei Ss046 fimbrial-like protein YP_311048.1 2264154 R 300269 CDS YP_311049.1 74312630 3667197 complement(2264939..2265220) 1 NC_007384.1 hypothetical protein 2265220 yehE 3667197 yehE Shigella sonnei Ss046 hypothetical protein YP_311049.1 2264939 R 300269 CDS YP_311050.2 161986505 3667198 complement(2265465..2266574) 1 NC_007384.1 Code: D; COG: COG0489; ATPase 2266574 mrp 3667198 mrp Shigella sonnei Ss046 ATPase YP_311050.2 2265465 R 300269 CDS YP_311051.1 74312632 3667199 2266706..2268739 1 NC_007384.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 2268739 metG 3667199 metG Shigella sonnei Ss046 methionyl-tRNA synthetase YP_311051.1 2266706 D 300269 CDS YP_311052.1 74312633 3667200 2268880..2269701 1 NC_007384.1 Code: S; COG: COG3831; molybdate metabolism regulator, first fragment 2269701 molR_1 3667200 molR_1 Shigella sonnei Ss046 molybdate metabolism regulator, first fragment YP_311052.1 2268880 D 300269 CDS YP_311053.1 74312634 3667201 complement(2269636..2270139) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2270139 3667201 SSON_2165 Shigella sonnei Ss046 IS1 ORF YP_311053.1 2269636 R 300269 CDS YP_311054.1 74312635 3667204 2272434..2274434 1 NC_007384.1 Code: L; COG: COG2801; hypothetical protein 2274434 yehQ 3667204 yehQ Shigella sonnei Ss046 hypothetical protein YP_311054.1 2272434 D 300269 CDS YP_311055.1 74312636 3667205 2274544..2275017 1 NC_007384.1 Code: S; COG: COG4808; hypothetical protein 2275017 yehR 3667205 yehR Shigella sonnei Ss046 hypothetical protein YP_311055.1 2274544 D 300269 CDS YP_311056.1 74312637 3667206 complement(2275058..2275528) 1 NC_007384.1 Code: S; COG: COG4807; hypothetical protein 2275528 yehS 3667206 yehS Shigella sonnei Ss046 hypothetical protein YP_311056.1 2275058 R 300269 CDS YP_311057.1 74312638 3667207 complement(2275575..2276309) 1 NC_007384.1 unknown function; when overproduced it confers drug-resistance; two-component response-regulatory protein YehT 2276309 yehT 3667207 yehT Shigella sonnei Ss046 two-component response-regulatory protein YehT YP_311057.1 2275575 R 300269 CDS YP_311058.1 74312639 3667208 complement(2276291..2277976) 1 NC_007384.1 Code: T; COG: COG3275; 2-component sensor protein 2277976 yehU 3667208 yehU Shigella sonnei Ss046 2-component sensor protein YP_311058.1 2276291 R 300269 CDS YP_311059.1 74312640 3667209 2278491..2278739 1 NC_007384.1 DNA damage-inducible protein 2278739 3667209 SSON_2173 Shigella sonnei Ss046 DNA damage-inducible protein YP_311059.1 2278491 D 300269 CDS YP_311060.1 74312641 3667210 complement(2278750..2279253) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2279253 3667210 SSON_2174 Shigella sonnei Ss046 IS1 ORF YP_311060.1 2278750 R 300269 CDS YP_311061.1 74312642 3667211 complement(2279897..2280259) 1 NC_007384.1 hypothetical protein 2280259 3667211 SSON_2175 Shigella sonnei Ss046 hypothetical protein YP_311061.1 2279897 R 300269 CDS YP_311062.1 74312643 3667212 complement(2280259..2281023) 1 NC_007384.1 Code: L; COG: COG3547; transposase 2281023 3667212 SSON_2176 Shigella sonnei Ss046 transposase YP_311062.1 2280259 R 300269 CDS YP_311063.1 74312644 3667213 complement(2281150..2281419) 1 NC_007384.1 hypothetical protein 2281419 3667213 SSON_2177 Shigella sonnei Ss046 hypothetical protein YP_311063.1 2281150 R 300269 CDS YP_311064.1 74312645 3666616 2281713..2282144 1 NC_007384.1 Code: QR; COG: COG0500; hypothetical protein 2282144 3666616 SSON_2178 Shigella sonnei Ss046 hypothetical protein YP_311064.1 2281713 D 300269 CDS YP_311065.1 74312646 3666617 2282460..2284103 1 NC_007384.1 Code: S; COG: COG4886; invasion plasmid antigen 2284103 ipaH_4 3666617 ipaH_4 Shigella sonnei Ss046 invasion plasmid antigen YP_311065.1 2282460 D 300269 CDS YP_311066.1 74312647 3666618 complement(2284283..2284906) 1 NC_007384.1 hypothetical protein 2284906 3666618 SSON_2180 Shigella sonnei Ss046 hypothetical protein YP_311066.1 2284283 R 300269 CDS YP_311067.1 74312648 3666619 2285620..2285922 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 2285922 3666619 SSON_2181 Shigella sonnei Ss046 IS600 ORF1 YP_311067.1 2285620 D 300269 CDS YP_311068.1 74312649 3666620 2286063..2287766 1 NC_007384.1 Code: L; COG: COG0582; integrase 2287766 3666620 SSON_2182 Shigella sonnei Ss046 integrase YP_311068.1 2286063 D 300269 CDS YP_311069.1 74312650 3666621 2287841..2288488 1 NC_007384.1 Code: K; COG: COG0789; transcriptional regulator 2288488 yehV 3666621 yehV Shigella sonnei Ss046 transcriptional regulator YP_311069.1 2287841 D 300269 CDS YP_311070.1 74312651 3666622 2288548..2288655 1 NC_007384.1 hypothetical protein 2288655 3666622 SSON_2184 Shigella sonnei Ss046 hypothetical protein YP_311070.1 2288548 D 300269 CDS YP_311071.1 74312652 3666623 complement(2288636..2289367) 1 NC_007384.1 Code: E; COG: COG1174; transport system permease 2289367 yehW 3666623 yehW Shigella sonnei Ss046 transport system permease YP_311071.1 2288636 R 300269 CDS YP_311072.1 74312653 3666624 complement(2289372..2290298) 1 NC_007384.1 Code: E; COG: COG1125; ABC transporter ATP-binding protein 2290298 yehX 3666624 yehX Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_311072.1 2289372 R 300269 CDS YP_311073.1 74312654 3666625 complement(2290291..2291448) 1 NC_007384.1 Code: E; COG: COG1174; transport system permease 2291448 yehY 3666625 yehY Shigella sonnei Ss046 transport system permease YP_311073.1 2290291 R 300269 CDS YP_311074.1 74312655 3666626 complement(2291455..2292372) 1 NC_007384.1 Code: M; COG: COG1732; transport system permease 2292372 yehZ 3666626 yehZ Shigella sonnei Ss046 transport system permease YP_311074.1 2291455 R 300269 CDS YP_311075.1 74312656 3666627 complement(2292624..2294921) 1 NC_007384.1 Code: G; COG: COG1472; beta-D-glucoside glucohydrolase, periplasmic 2294921 bglX 3666627 bglX Shigella sonnei Ss046 beta-D-glucoside glucohydrolase, periplasmic YP_311075.1 2292624 R 300269 CDS YP_311076.1 74312657 3666628 2295117..2296832 1 NC_007384.1 FAD protein; NADH independent; component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 2296832 dld 3666628 dld Shigella sonnei Ss046 D-lactate dehydrogenase YP_311076.1 2295117 D 300269 CDS YP_311077.1 74312658 3666629 complement(2296871..2297812) 1 NC_007384.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase 2297812 pbpG 3666629 pbpG Shigella sonnei Ss046 D-alanyl-D-alanine endopeptidase YP_311077.1 2296871 R 300269 CDS YP_311078.1 74312659 3666630 complement(2297977..2298588) 1 NC_007384.1 hypothetical protein 2298588 yohC 3666630 yohC Shigella sonnei Ss046 hypothetical protein YP_311078.1 2297977 R 300269 CDS YP_311079.1 74312660 3666631 2298698..2299312 1 NC_007384.1 Code: S; COG: COG0586; hypothetical protein 2299312 yohD 3666631 yohD Shigella sonnei Ss046 hypothetical protein YP_311079.1 2298698 D 300269 CDS YP_311080.1 74312661 3666632 complement(2299442..2300203) 1 NC_007384.1 Code: IQR; COG: COG1028; acetoin dehydrogenase 2300203 yohF 3666632 yohF Shigella sonnei Ss046 acetoin dehydrogenase YP_311080.1 2299442 R 300269 CDS YP_311081.2 161986504 3666633 complement(2300256..2301692) 1 NC_007384.1 may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance outer membrane protein MdtQ 2301692 yohG 3666633 yohG Shigella sonnei Ss046 multidrug resistance outer membrane protein MdtQ YP_311081.2 2300256 R 300269 CDS YP_311082.1 74312663 3666634 complement(2302372..2303319) 1 NC_007384.1 Code: J; COG: COG0042; tRNA-dihydrouridine synthase C 2303319 yohI 3666634 yohI Shigella sonnei Ss046 tRNA-dihydrouridine synthase C YP_311082.1 2302372 R 300269 CDS YP_311083.1 74312664 3667633 2303558..2303956 1 NC_007384.1 Code: R; COG: COG1380; hypothetical protein 2303956 yohJ 3667633 yohJ Shigella sonnei Ss046 hypothetical protein YP_311083.1 2303558 D 300269 CDS YP_311084.1 74312665 3667634 2303953..2304648 1 NC_007384.1 Code: M; COG: COG1346; hypothetical protein 2304648 yohK 3667634 yohK Shigella sonnei Ss046 hypothetical protein YP_311084.1 2303953 D 300269 CDS YP_311085.1 74312666 3667635 2304778..2305662 1 NC_007384.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2305662 cdd 3667635 cdd Shigella sonnei Ss046 cytidine deaminase YP_311085.1 2304778 D 300269 CDS YP_311086.1 74312667 3667636 2305812..2306531 1 NC_007384.1 Code: S; COG: COG2949; hypothetical protein 2306531 sanA 3667636 sanA Shigella sonnei Ss046 hypothetical protein YP_311086.1 2305812 D 300269 CDS YP_311087.1 74312668 3667637 2306534..2306773 1 NC_007384.1 hypothetical protein 2306773 3667637 SSON_2201 Shigella sonnei Ss046 hypothetical protein YP_311087.1 2306534 D 300269 CDS YP_311088.2 161986503 3667639 2308199..2309434 1 NC_007384.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines; dihydropyrimidine dehydrogenase 2309434 yeiA 3667639 yeiA Shigella sonnei Ss046 dihydropyrimidine dehydrogenase YP_311088.2 2308199 D 300269 CDS YP_311089.1 74312670 3667640 complement(2309561..2310571) 1 NC_007384.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane protein 2310571 mglC 3667640 mglC Shigella sonnei Ss046 beta-methylgalactoside transporter inner membrane protein YP_311089.1 2309561 R 300269 CDS YP_311090.1 74312671 3667641 complement(2310587..2312107) 1 NC_007384.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein 2312107 mglA 3667641 mglA Shigella sonnei Ss046 galactose/methyl galaxtoside transporter ATP-binding protein YP_311090.1 2310587 R 300269 CDS YP_311091.1 74312672 3667642 complement(2312168..2313166) 1 NC_007384.1 receptor for galactose taxis; Code: G; COG: COG1879; galactose-binding transport protein 2313166 mglB 3667642 mglB Shigella sonnei Ss046 galactose-binding transport protein YP_311091.1 2312168 R 300269 CDS YP_311092.1 74312673 3667643 complement(2313446..2314369) 1 NC_007384.1 galactose operon inducer; negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS 2314369 galS 3667643 galS Shigella sonnei Ss046 DNA-binding transcriptional regulator GalS YP_311092.1 2313446 R 300269 CDS YP_311093.1 74312674 3667644 complement(2314628..2315785) 1 NC_007384.1 Code: S; COG: COG2311; hypothetical protein 2315785 yeiB 3667644 yeiB Shigella sonnei Ss046 hypothetical protein YP_311093.1 2314628 R 300269 CDS YP_311094.1 74312675 3667645 complement(2315802..2316470) 1 NC_007384.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 2316470 folE 3667645 folE Shigella sonnei Ss046 GTP cyclohydrolase I YP_311094.1 2315802 R 300269 CDS YP_311095.1 74312676 3667646 2316728..2317564 1 NC_007384.1 Code: R; COG: COG0627; esterase 2317564 yeiG 3667646 yeiG Shigella sonnei Ss046 esterase YP_311095.1 2316728 D 300269 CDS YP_311096.1 74312677 3667647 complement(2317596..2319587) 1 NC_007384.1 porin; requires tonB gene product; Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein; colicin I receptor 2319587 cirA 3667647 cirA Shigella sonnei Ss046 colicin I receptor YP_311096.1 2317596 R 300269 CDS YP_311097.1 74312678 3667648 complement(2319879..2321348) 1 NC_007384.1 Code: E; COG: COG0833; lysine transporter 2321348 lysP 3667648 lysP Shigella sonnei Ss046 lysine transporter YP_311097.1 2319879 R 300269 CDS YP_311098.1 74312679 3667649 complement(2321553..2322434) 1 NC_007384.1 Code: K; COG: COG0583; DNA-binding transcriptional regulator 2322434 yeiE 3667649 yeiE Shigella sonnei Ss046 DNA-binding transcriptional regulator YP_311098.1 2321553 R 300269 CDS YP_311099.1 74312680 3667650 2322533..2323582 1 NC_007384.1 Code: S; COG: COG2855; hypothetical protein 2323582 yeiH 3667650 yeiH Shigella sonnei Ss046 hypothetical protein YP_311099.1 2322533 D 300269 CDS YP_311100.1 74312681 3667651 2323656..2324513 1 NC_007384.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2324513 nfo 3667651 nfo Shigella sonnei Ss046 endonuclease IV YP_311100.1 2323656 D 300269 CDS YP_311101.1 74312682 3667652 2324517..2325605 1 NC_007384.1 Code: G; COG: COG0524; hypothetical protein 2325605 yeiI 3667652 yeiI Shigella sonnei Ss046 hypothetical protein YP_311101.1 2324517 D 300269 CDS YP_311102.1 74312683 3667808 complement(2325661..2326911) 1 NC_007384.1 Code: F; COG: COG1972; transport system permease 2326911 yeiJ 3667808 yeiJ Shigella sonnei Ss046 transport system permease YP_311102.1 2325661 R 300269 CDS YP_311103.1 74312684 3667809 complement(2327011..2327952) 1 NC_007384.1 Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 2327952 rihB 3667809 rihB Shigella sonnei Ss046 ribonucleoside hydrolase 2 YP_311103.1 2327011 R 300269 CDS YP_311104.1 74312685 3667810 2328121..2328780 1 NC_007384.1 activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 2328780 yeiL 3667810 yeiL Shigella sonnei Ss046 DNA-binding transcriptional activator YeiL YP_311104.1 2328121 D 300269 CDS YP_311105.1 74312686 3667811 complement(2328847..2330097) 1 NC_007384.1 Code: F; COG: COG1972; transport system permease 2330097 yeiM 3667811 yeiM Shigella sonnei Ss046 transport system permease YP_311105.1 2328847 R 300269 CDS YP_311106.1 74312687 3667812 complement(2330191..2331129) 1 NC_007384.1 Code: Q; COG: COG2313; hypothetical protein 2331129 yeiN 3667812 yeiN Shigella sonnei Ss046 hypothetical protein YP_311106.1 2330191 R 300269 CDS YP_311107.1 74312688 3667813 complement(2331117..2332058) 1 NC_007384.1 Code: G; COG: COG0524; hypothetical protein 2332058 yeiC 3667813 yeiC Shigella sonnei Ss046 hypothetical protein YP_311107.1 2331117 R 300269 CDS YP_311108.1 74312689 3667814 complement(2332516..2334207) 1 NC_007384.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunit IIBC 2334207 fruA 3667814 fruA Shigella sonnei Ss046 PTS system fructose-specific transporter subunit IIBC YP_311108.1 2332516 R 300269 CDS YP_311109.1 74312690 3667815 complement(2334224..2335162) 1 NC_007384.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase 2335162 fruK 3667815 fruK Shigella sonnei Ss046 1-phosphofructokinase YP_311109.1 2334224 R 300269 CDS YP_311110.1 74312691 3667816 complement(2335162..2336292) 1 NC_007384.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; PTS system fructose-specific transporter subunit IIA/HPr protein 2336292 fruB 3667816 fruB Shigella sonnei Ss046 PTS system fructose-specific transporter subunit IIA/HPr protein YP_311110.1 2335162 R 300269 CDS YP_311111.1 74312692 3667817 2336660..2337841 1 NC_007384.1 Code: GEPR; COG: COG0477; transport 2337841 yeiO 3667817 yeiO Shigella sonnei Ss046 transport YP_311111.1 2336660 D 300269 CDS YP_311112.2 161986502 3667818 2338247..2338819 1 NC_007384.1 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 2338819 yeiP 3667818 yeiP Shigella sonnei Ss046 elongation factor P YP_311112.2 2338247 D 300269 CDS YP_311113.1 74312694 3667819 2339042..2340508 1 NC_007384.1 Code: G; COG: COG0246; oxidoreductase 2340508 yeiQ 3667819 yeiQ Shigella sonnei Ss046 oxidoreductase YP_311113.1 2339042 D 300269 CDS YP_311114.1 74312695 3667820 2340626..2341612 1 NC_007384.1 Code: R; COG: COG0523; hypothetical protein 2341612 yeiR 3667820 yeiR Shigella sonnei Ss046 hypothetical protein YP_311114.1 2340626 D 300269 CDS YP_311115.1 74312696 3667821 2341615..2342364 1 NC_007384.1 Code: I; COG: COG0671; hypothetical protein 2342364 3667821 SSON_2230 Shigella sonnei Ss046 hypothetical protein YP_311115.1 2341615 D 300269 CDS YP_311116.1 74312697 3667822 2342776..2343342 1 NC_007384.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance; outer membrane lipoprotein 2343342 spr 3667822 spr Shigella sonnei Ss046 outer membrane lipoprotein YP_311116.1 2342776 D 300269 CDS YP_311117.1 74312698 3667823 2343523..2345079 1 NC_007384.1 Code: T; COG: COG2200; hypothetical protein 2345079 rtn 3667823 rtn Shigella sonnei Ss046 hypothetical protein YP_311117.1 2343523 D 300269 CDS YP_311118.1 74312699 3667824 2345161..2346975 1 NC_007384.1 Code: E; COG: COG4166; hypothetical protein 2346975 yejA 3667824 yejA Shigella sonnei Ss046 hypothetical protein YP_311118.1 2345161 D 300269 CDS YP_311119.1 74312700 3667825 2346976..2348070 1 NC_007384.1 Code: R; COG: COG4174; transport system permease 2348070 yejB 3667825 yejB Shigella sonnei Ss046 transport system permease YP_311119.1 2346976 D 300269 CDS YP_311120.1 74312701 3667826 2348070..2349095 1 NC_007384.1 Code: R; COG: COG4239; transport system permease 2349095 yejE 3667826 yejE Shigella sonnei Ss046 transport system permease YP_311120.1 2348070 D 300269 CDS YP_311121.1 74312702 3667862 2349097..2350686 1 NC_007384.1 Code: R; COG: COG4172; ABC transporter ATP-binding protein 2350686 yejF 3667862 yejF Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_311121.1 2349097 D 300269 CDS YP_311122.1 74312703 3667863 complement(2350690..2351034) 1 NC_007384.1 hypothetical protein 2351034 yejG 3667863 yejG Shigella sonnei Ss046 hypothetical protein YP_311122.1 2350690 R 300269 CDS YP_311123.1 74312704 3667865 complement(2352515..2353210) 1 NC_007384.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A 2353210 rsuA 3667865 rsuA Shigella sonnei Ss046 16S rRNA pseudouridylate synthase A YP_311123.1 2352515 R 300269 CDS YP_311124.1 74312705 3667866 2353360..2355120 1 NC_007384.1 Code: KL; COG: COG1061; ATP-dependent helicase 2355120 yejH 3667866 yejH Shigella sonnei Ss046 ATP-dependent helicase YP_311124.1 2353360 D 300269 CDS YP_311125.1 74312706 3667867 2355245..2355529 1 NC_007384.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 2355529 rplY 3667867 rplY Shigella sonnei Ss046 50S ribosomal protein L25 YP_311125.1 2355245 D 300269 CDS YP_311126.1 74312707 3667868 complement(2355668..2356675) 1 NC_007384.1 Code: R; COG: COG3081; nucleoid-associated protein NdpA 2356675 yejK 3667868 yejK Shigella sonnei Ss046 nucleoid-associated protein NdpA YP_311126.1 2355668 R 300269 CDS YP_311127.1 74312708 3667869 2356857..2357084 1 NC_007384.1 Code: S; COG: COG3082; hypothetical protein 2357084 yejL 3667869 yejL Shigella sonnei Ss046 hypothetical protein YP_311127.1 2356857 D 300269 CDS YP_311128.1 74312709 3667870 2357104..2358864 1 NC_007384.1 Code: R; COG: COG3083; sulfatase 2358864 yejM 3667870 yejM Shigella sonnei Ss046 sulfatase YP_311128.1 2357104 D 300269 CDS YP_311129.1 74312710 3667872 complement(2361132..2361767) 1 NC_007384.1 Code: L; COG: COG2801; IS2 ORF2 2361767 3667872 SSON_2246 Shigella sonnei Ss046 IS2 ORF2 YP_311129.1 2361132 R 300269 CDS YP_311130.1 74312711 3667873 2361833..2363005 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 2363005 3667873 SSON_2247 Shigella sonnei Ss046 IS21 ORF1 YP_311130.1 2361833 D 300269 CDS YP_311131.1 74312712 3667874 2363005..2363802 1 NC_007384.1 Code: L; COG: COG1484; IS21 ORF2 2363802 3667874 SSON_2248 Shigella sonnei Ss046 IS21 ORF2 YP_311131.1 2363005 D 300269 CDS YP_311132.1 74312713 3667875 complement(2363812..2364171) 1 NC_007384.1 IS2 ORF2 2364171 3667875 SSON_2249 Shigella sonnei Ss046 IS2 ORF2 YP_311132.1 2363812 R 300269 CDS YP_311133.1 74312714 3667877 2365276..2365923 1 NC_007384.1 sensor NarQ; nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 2365923 narP 3667877 narP Shigella sonnei Ss046 transcriptional regulator NarP YP_311133.1 2365276 D 300269 CDS YP_311134.1 74312715 3667878 complement(2365958..2367010) 1 NC_007384.1 Code: O; COG: COG4235; subunit of heme lyase 2367010 ccmH 3667878 ccmH Shigella sonnei Ss046 subunit of heme lyase YP_311134.1 2365958 R 300269 CDS YP_311135.1 74312716 3667879 complement(2367007..2367564) 1 NC_007384.1 possibly involved in biogenesis of cytochrome c; Code: OC; COG: COG0526; disulfide oxidoreductase 2367564 dsbE 3667879 dsbE Shigella sonnei Ss046 disulfide oxidoreductase YP_311135.1 2367007 R 300269 CDS YP_311136.1 74312717 3667880 complement(2367561..2369504) 1 NC_007384.1 Code: O; COG: COG1138; cytochrome c-type biogenesis protein 2369504 ccmF 3667880 ccmF Shigella sonnei Ss046 cytochrome c-type biogenesis protein YP_311136.1 2367561 R 300269 CDS YP_311137.1 74312718 3667881 complement(2369501..2369980) 1 NC_007384.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 2369980 ccmE 3667881 ccmE Shigella sonnei Ss046 cytochrome c-type biogenesis protein CcmE YP_311137.1 2369501 R 300269 CDS YP_311138.1 74312719 3667882 complement(2369977..2370186) 1 NC_007384.1 Code: U; COG: COG3114; heme exporter protein C 2370186 ccmD 3667882 ccmD Shigella sonnei Ss046 heme exporter protein C YP_311138.1 2369977 R 300269 CDS YP_311139.1 74312720 3667883 complement(2370183..2370920) 1 NC_007384.1 Code: O; COG: COG0755; heme exporter protein C 2370920 ccmC 3667883 ccmC Shigella sonnei Ss046 heme exporter protein C YP_311139.1 2370183 R 300269 CDS YP_311140.1 74312721 3667884 complement(2370962..2371624) 1 NC_007384.1 Code: O; COG: COG2386; heme exporter protein B, cytochrome c-type biogenesis protein 2371624 ccmB 3667884 ccmB Shigella sonnei Ss046 heme exporter protein B, cytochrome c-type biogenesis protein YP_311140.1 2370962 R 300269 CDS YP_311141.1 74312722 3667885 complement(2371621..2372238) 1 NC_007384.1 ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 2372238 ccmA 3667885 ccmA Shigella sonnei Ss046 cytochrome c biogenesis protein CcmA YP_311141.1 2371621 R 300269 CDS YP_311142.1 74312723 3667886 complement(2372257..2372859) 1 NC_007384.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC 2372859 napC 3667886 napC Shigella sonnei Ss046 cytochrome c-type protein NapC YP_311142.1 2372257 R 300269 CDS YP_311143.2 161986501 3667887 complement(2372869..2373318) 1 NC_007384.1 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit 2373318 napB 3667887 napB Shigella sonnei Ss046 citrate reductase cytochrome c-type subunit YP_311143.2 2372869 R 300269 CDS YP_311144.1 74312725 3667888 complement(2373315..2374178) 1 NC_007384.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component 2374178 napH 3667888 napH Shigella sonnei Ss046 quinol dehydrogenase membrane component YP_311144.1 2373315 R 300269 CDS YP_311145.1 74312726 3667889 complement(2374165..2374860) 1 NC_007384.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component 2374860 napG 3667889 napG Shigella sonnei Ss046 quinol dehydrogenase periplasmic component YP_311145.1 2374165 R 300269 CDS YP_311146.1 74312727 3667890 complement(2374867..2377353) 1 NC_007384.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit 2377353 napA 3667890 napA Shigella sonnei Ss046 nitrate reductase catalytic subunit YP_311146.1 2374867 R 300269 CDS YP_311147.1 74312728 3667891 complement(2377350..2377613) 1 NC_007384.1 Code: P; COG: COG3062; assembly protein for periplasmic nitrate reductase 2377613 napD 3667891 napD Shigella sonnei Ss046 assembly protein for periplasmic nitrate reductase YP_311147.1 2377350 R 300269 CDS YP_311148.1 74312729 3667892 complement(2377603..2378097) 1 NC_007384.1 Predicted role in electron transfer to the periplasmic nitrate reductase protein NapA.; ferredoxin-type protein 2378097 napF 3667892 napF Shigella sonnei Ss046 ferredoxin-type protein YP_311148.1 2377603 R 300269 CDS YP_311149.1 74312730 3667893 2378505..2378993 1 NC_007384.1 a serine protease inhibitor; serine protease inhibitor, inhibits trypsin and other proteases; ecotin 2378993 eco 3667893 eco Shigella sonnei Ss046 ecotin YP_311149.1 2378505 D 300269 CDS YP_311150.1 74312731 3667894 complement(2379302..2380948) 1 NC_007384.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 2380948 yojH 3667894 yojH Shigella sonnei Ss046 malate:quinone oxidoreductase YP_311150.1 2379302 R 300269 CDS YP_311151.1 74312732 3667895 complement(2381166..2382809) 1 NC_007384.1 efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane component/ATP-binding protein 2382809 yojI 3667895 yojI Shigella sonnei Ss046 multidrug transporter membrane component/ATP-binding protein YP_311151.1 2381166 R 300269 CDS YP_311152.1 74312733 3667896 complement(2382885..2383535) 1 NC_007384.1 Code: L; COG: COG3145; DNA repair system specific for alkylated DNA 2383535 alkB 3667896 alkB Shigella sonnei Ss046 DNA repair system specific for alkylated DNA YP_311152.1 2382885 R 300269 CDS YP_311153.1 74312734 3667897 complement(2383535..2384599) 1 NC_007384.1 transcription activator/repressor; Code: F; COG: COG2169; O6-methylguanine-DNA methyltransferase 2384599 ada 3667897 ada Shigella sonnei Ss046 O6-methylguanine-DNA methyltransferase YP_311153.1 2383535 R 300269 CDS YP_311154.1 74312735 3667898 complement(2384673..2385728) 1 NC_007384.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE 2385728 yojL 3667898 yojL Shigella sonnei Ss046 thiamine biosynthesis lipoprotein ApbE YP_311154.1 2384673 R 300269 CDS YP_311155.1 74312736 3667899 complement(2385840..2386946) 1 NC_007384.1 allows for ions and hydrophilic solutes to cross the outer membrane; porin 2386946 ompC 3667899 ompC Shigella sonnei Ss046 porin YP_311155.1 2385840 R 300269 CDS YP_311156.1 74312737 3667940 complement(2387200..2387703) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2387703 3667940 SSON_2274 Shigella sonnei Ss046 IS1 ORF YP_311156.1 2387200 R 300269 CDS YP_311157.1 74312738 3667941 2388461..2391133 1 NC_007384.1 Code: T; COG: COG0642; phosphotransfer intermediate protein in two-component regulatory system with RcsBC 2391133 yojN 3667941 yojN Shigella sonnei Ss046 phosphotransfer intermediate protein in two-component regulatory system with RcsBC YP_311157.1 2388461 D 300269 CDS YP_311158.1 74312739 3667942 2391150..2391800 1 NC_007384.1 sensor RcsC; two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 2391800 rcsB 3667942 rcsB Shigella sonnei Ss046 transcriptional regulator RcsB YP_311158.1 2391150 D 300269 CDS YP_311159.2 161986500 3667943 complement(2392000..2394849) 1 NC_007384.1 probable histidine kinase acting on RcsB; Code: T; COG: COG0642; hybrid sensory kinase in two-component regulatory system with RcsB and YojN 2394849 rcsC 3667943 rcsC Shigella sonnei Ss046 hybrid sensory kinase in two-component regulatory system with RcsB and YojN YP_311159.2 2392000 R 300269 CDS YP_311160.1 74312741 3667944 2395016..2396842 1 NC_007384.1 with AtoC is a member of a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; sensory histidine kinase AtoS 2396842 atoS 3667944 atoS Shigella sonnei Ss046 sensory histidine kinase AtoS YP_311160.1 2395016 D 300269 CDS YP_311161.1 74312742 3667945 2396839..2398224 1 NC_007384.1 sensor ATOS; ornithine decarboxylase antizyme; with AtoS is a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; acetoacetate metabolism regulatory protein AtoC 2398224 atoC 3667945 atoC Shigella sonnei Ss046 acetoacetate metabolism regulatory protein AtoC YP_311161.1 2396839 D 300269 CDS YP_311162.1 74312743 3667946 2398420..2399082 1 NC_007384.1 Code: I; COG: COG1788; acetyl-CoA:acetoacetyl-CoA transferase subunit alpha 2399082 atoD 3667946 atoD Shigella sonnei Ss046 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha YP_311162.1 2398420 D 300269 CDS YP_311163.1 74312744 3667947 2399082..2399732 1 NC_007384.1 Code: I; COG: COG2057; acetyl-CoA:acetoacetyl-CoA transferase subunit beta 2399732 atoA 3667947 atoA Shigella sonnei Ss046 acetyl-CoA:acetoacetyl-CoA transferase subunit beta YP_311163.1 2399082 D 300269 CDS YP_311164.1 74312745 3667948 2399729..2401051 1 NC_007384.1 Code: I; COG: COG2031; short chain fatty acid transporter 2401051 atoE 3667948 atoE Shigella sonnei Ss046 short chain fatty acid transporter YP_311164.1 2399729 D 300269 CDS YP_311165.1 74312746 3667949 2401082..2402266 1 NC_007384.1 Code: I; COG: COG0183; acetyl-CoA acetyltransferase 2402266 atoB 3667949 atoB Shigella sonnei Ss046 acetyl-CoA acetyltransferase YP_311165.1 2401082 D 300269 CDS YP_311166.1 74312747 3667950 complement(2402340..2403116) 1 NC_007384.1 Code: S; COG: COG4676; hypothetical protein 2403116 3667950 SSON_2284 Shigella sonnei Ss046 hypothetical protein YP_311166.1 2402340 R 300269 CDS YP_311167.1 74312748 3667951 complement(2403121..2404770) 1 NC_007384.1 Code: S; COG: COG5445; hypothetical protein 2404770 3667951 SSON_2285 Shigella sonnei Ss046 hypothetical protein YP_311167.1 2403121 R 300269 CDS YP_311168.1 74312749 3667953 complement(2406502..2407005) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2407005 3667953 SSON_2287 Shigella sonnei Ss046 IS1 ORF YP_311168.1 2406502 R 300269 CDS YP_311169.1 74312750 3667954 complement(2407233..2408732) 1 NC_007384.1 Code: S; COG: COG4685; hypothetical protein 2408732 yfaA 3667954 yfaA Shigella sonnei Ss046 hypothetical protein YP_311169.1 2407233 R 300269 CDS YP_311170.1 74312751 3667955 complement(2408970..2411597) 1 NC_007384.1 type II topoisomerase; negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 2411597 gyrA 3667955 gyrA Shigella sonnei Ss046 DNA gyrase subunit A YP_311170.1 2408970 R 300269 CDS YP_311171.1 74312752 3667956 2411744..2412466 1 NC_007384.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2412466 ubiG 3667956 ubiG Shigella sonnei Ss046 3-demethylubiquinone-9 3-methyltransferase YP_311171.1 2411744 D 300269 CDS YP_311172.2 161986499 3667957 2415858..2416763 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2416763 3667957 SSON_2291 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_311172.2 2415858 D 300269 CDS YP_311173.1 74312754 3667959 2418378..2420663 1 NC_007384.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2420663 nrdA 3667959 nrdA Shigella sonnei Ss046 ribonucleotide-diphosphate reductase subunit alpha YP_311173.1 2418378 D 300269 CDS YP_311174.1 74312755 3668185 2420897..2422027 1 NC_007384.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 2422027 nrdB 3668185 nrdB Shigella sonnei Ss046 ribonucleotide-diphosphate reductase subunit beta YP_311174.1 2420897 D 300269 CDS YP_311175.1 74312756 3668186 2422027..2422281 1 NC_007384.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin 2422281 yfaE 3668186 yfaE Shigella sonnei Ss046 2Fe-2S ferredoxin YP_311175.1 2422027 D 300269 CDS YP_311176.1 74312757 3668187 complement(2422358..2422984) 1 NC_007384.1 involved in stress response; hypothetical protein 2422984 inaA 3668187 inaA Shigella sonnei Ss046 hypothetical protein YP_311176.1 2422358 R 300269 CDS YP_311177.1 74312758 3668188 complement(2423355..2424023) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 2424023 3668188 SSON_2297 Shigella sonnei Ss046 IS600 ORF2 YP_311177.1 2423355 R 300269 CDS YP_311178.1 74312759 3668189 2424376..2425215 1 NC_007384.1 Code: L; COG: COG2801; IS911 ORF2 2425215 3668189 SSON_2298 Shigella sonnei Ss046 IS911 ORF2 YP_311178.1 2424376 D 300269 CDS YP_311179.1 74312760 3668190 complement(2425461..2425763) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 2425763 3668190 SSON_2299 Shigella sonnei Ss046 IS600 ORF1 YP_311179.1 2425461 R 300269 CDS YP_311180.1 74312761 3668191 complement(2425966..2427042) 1 NC_007384.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase 2427042 glpQ 3668191 glpQ Shigella sonnei Ss046 glycerophosphodiester phosphodiesterase YP_311180.1 2425966 R 300269 CDS YP_311181.1 74312762 3668192 complement(2427047..2428405) 1 NC_007384.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter 2428405 glpT 3668192 glpT Shigella sonnei Ss046 sn-glycerol-3-phosphate transporter YP_311181.1 2427047 R 300269 CDS YP_311182.1 74312763 3668193 2428678..2430306 1 NC_007384.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 2430306 glpA 3668193 glpA Shigella sonnei Ss046 sn-glycerol-3-phosphate dehydrogenase subunit A YP_311182.1 2428678 D 300269 CDS YP_311183.1 74312764 3668194 2430296..2431555 1 NC_007384.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 2431555 glpB 3668194 glpB Shigella sonnei Ss046 anaerobic glycerol-3-phosphate dehydrogenase subunit B YP_311183.1 2430296 D 300269 CDS YP_311184.1 74312765 3668195 2431552..2432742 1 NC_007384.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 2432742 glpC 3668195 glpC Shigella sonnei Ss046 sn-glycerol-3-phosphate dehydrogenase subunit C YP_311184.1 2431552 D 300269 CDS YP_311185.1 74312766 3668196 2432935..2433837 1 NC_007384.1 Code: S; COG: COG5464; hypothetical protein 2433837 yfaD 3668196 yfaD Shigella sonnei Ss046 hypothetical protein YP_311185.1 2432935 D 300269 CDS YP_311186.1 74312767 3668197 complement(2433878..2434681) 1 NC_007384.1 Code: G; COG: COG3836; aldolase 2434681 3668197 SSON_2306 Shigella sonnei Ss046 aldolase YP_311186.1 2433878 R 300269 CDS YP_311187.1 74312768 3668198 complement(2434699..2436027) 1 NC_007384.1 Code: GEPR; COG: COG0477; transporter 2436027 3668198 SSON_2307 Shigella sonnei Ss046 transporter YP_311187.1 2434699 R 300269 CDS YP_311188.1 74312769 3668199 complement(2436045..2437331) 1 NC_007384.1 Code: MR; COG: COG4948; racemase 2437331 3668199 SSON_2308 Shigella sonnei Ss046 racemase YP_311188.1 2436045 R 300269 CDS YP_311189.1 74312770 3668200 complement(2437264..2438046) 1 NC_007384.1 Code: K; COG: COG1414; regulator 2438046 3668200 SSON_2309 Shigella sonnei Ss046 regulator YP_311189.1 2437264 R 300269 CDS YP_311190.1 74312771 3668201 complement(2438266..2439468) 1 NC_007384.1 Code: R; COG: COG1058; competence damage-inducible protein A 2439468 3668201 SSON_2310 Shigella sonnei Ss046 competence damage-inducible protein A YP_311190.1 2438266 R 300269 CDS YP_311191.1 74312772 3668202 complement(2439568..2440131) 1 NC_007384.1 hypothetical protein 2440131 3668202 SSON_2311 Shigella sonnei Ss046 hypothetical protein YP_311191.1 2439568 R 300269 CDS YP_311192.1 74312773 3668203 2440389..2440814 1 NC_007384.1 Code: LR; COG: COG0494; hypothetical protein 2440814 yfaO 3668203 yfaO Shigella sonnei Ss046 hypothetical protein YP_311192.1 2440389 D 300269 CDS YP_311193.1 74312774 3668372 complement(2440853..2441455) 1 NC_007384.1 protein induced by aluminum 2441455 ais 3668372 ais Shigella sonnei Ss046 protein induced by aluminum YP_311193.1 2440853 R 300269 CDS YP_311194.2 161986498 3668373 2441763..2442902 1 NC_007384.1 catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 2442902 3668373 SSON_2314 Shigella sonnei Ss046 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase YP_311194.2 2441763 D 300269 CDS YP_311195.1 74312776 3668374 2442906..2443874 1 NC_007384.1 catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 2443874 3668374 SSON_2315 Shigella sonnei Ss046 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase YP_311195.1 2442906 D 300269 CDS YP_311196.1 74312777 3668375 2443874..2445856 1 NC_007384.1 Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 2445856 3668375 SSON_2316 Shigella sonnei Ss046 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase YP_311196.1 2443874 D 300269 CDS YP_311197.1 74312778 3668376 2445853..2446743 1 NC_007384.1 Code: G; COG: COG0726; hypothetical protein 2446743 3668376 SSON_2317 Shigella sonnei Ss046 hypothetical protein YP_311197.1 2445853 D 300269 CDS YP_311198.1 74312779 3668377 2446743..2448395 1 NC_007384.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 2448395 arnT 3668377 arnT Shigella sonnei Ss046 4-amino-4-deoxy-L-arabinose transferase YP_311198.1 2446743 D 300269 CDS YP_311199.2 161986497 3668378 2448727..2449113 1 NC_007384.1 Code: GER; COG: COG0697; hypothetical protein 2449113 3668378 SSON_2319 Shigella sonnei Ss046 hypothetical protein YP_311199.2 2448727 D 300269 CDS YP_311200.1 74312781 3668379 complement(2449107..2449403) 1 NC_007384.1 polymyxin resistance protein B 2449403 pmrD 3668379 pmrD Shigella sonnei Ss046 polymyxin resistance protein B YP_311200.1 2449107 R 300269 CDS YP_311201.1 74312782 3668380 complement(2449417..2450838) 1 NC_007384.1 Code: IQ; COG: COG0318; O-succinylbenzoic acid--CoA ligase 2450838 menE 3668380 menE Shigella sonnei Ss046 O-succinylbenzoic acid--CoA ligase YP_311201.1 2449417 R 300269 CDS YP_311202.1 74312783 3668381 complement(2450835..2451797) 1 NC_007384.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 2451797 menC 3668381 menC Shigella sonnei Ss046 O-succinylbenzoate synthase YP_311202.1 2450835 R 300269 CDS YP_311203.1 74312784 3668382 complement(2451797..2452654) 1 NC_007384.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 2452654 menB 3668382 menB Shigella sonnei Ss046 naphthoate synthase YP_311203.1 2451797 R 300269 CDS YP_311204.1 74312785 3668383 complement(2452669..2453427) 1 NC_007384.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase 2453427 yfbB 3668383 yfbB Shigella sonnei Ss046 acyl-CoA thioester hydrolase YP_311204.1 2452669 R 300269 CDS YP_311205.1 74312786 3668384 complement(2453424..2455094) 1 NC_007384.1 SHCHC synthase; SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 2455094 menD 3668384 menD Shigella sonnei Ss046 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase YP_311205.1 2453424 R 300269 CDS YP_311206.2 161986496 3668385 complement(2455183..2456478) 1 NC_007384.1 menaquinone biosynthesis; Code: HQ; COG: COG1169; isochorismate hydroxymutase 2456478 menF 3668385 menF Shigella sonnei Ss046 isochorismate hydroxymutase YP_311206.2 2455183 R 300269 CDS YP_311207.1 74312788 3668386 complement(2456557..2456862) 1 NC_007384.1 Code: S; COG: COG4575; hypothetical protein 2456862 elaB 3668386 elaB Shigella sonnei Ss046 hypothetical protein YP_311207.1 2456557 R 300269 CDS YP_311208.1 74312789 3668387 complement(2456917..2457300) 1 NC_007384.1 Code: R; COG: COG2153; hypothetical protein 2457300 elaA 3668387 elaA Shigella sonnei Ss046 hypothetical protein YP_311208.1 2456917 R 300269 CDS YP_311209.2 161986495 3668388 2457443..2458360 1 NC_007384.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2458360 elaC 3668388 elaC Shigella sonnei Ss046 ribonuclease Z YP_311209.2 2457443 D 300269 CDS YP_311210.1 74312791 3668389 2458616..2459119 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2459119 3668389 SSON_2330 Shigella sonnei Ss046 IS1 ORF YP_311210.1 2458616 D 300269 CDS YP_311211.1 74312792 3668390 complement(2459709..2460212) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2460212 3668390 SSON_2331 Shigella sonnei Ss046 IS1 ORF YP_311211.1 2459709 R 300269 CDS YP_311212.1 74312793 3668391 2460479..2460919 1 NC_007384.1 hypothetical protein 2460919 yfbM 3668391 yfbM Shigella sonnei Ss046 hypothetical protein YP_311212.1 2460479 D 300269 CDS YP_311213.2 161986494 3668507 complement(2461048..2462505) 1 NC_007384.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 2462505 nuoN 3668507 nuoN Shigella sonnei Ss046 NADH dehydrogenase subunit N YP_311213.2 2461048 R 300269 CDS YP_311214.1 74312795 3668508 complement(2462512..2464041) 1 NC_007384.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 2464041 nuoM 3668508 nuoM Shigella sonnei Ss046 NADH dehydrogenase subunit M YP_311214.1 2462512 R 300269 CDS YP_311215.1 74312796 3668509 complement(2464205..2466046) 1 NC_007384.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 2466046 nuoL 3668509 nuoL Shigella sonnei Ss046 NADH dehydrogenase subunit L YP_311215.1 2464205 R 300269 CDS YP_311216.1 74312797 3668510 complement(2466043..2466345) 1 NC_007384.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 2466345 nuoK 3668510 nuoK Shigella sonnei Ss046 NADH dehydrogenase subunit K YP_311216.1 2466043 R 300269 CDS YP_311217.1 74312798 3668511 complement(2466342..2466896) 1 NC_007384.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 2466896 nuoJ 3668511 nuoJ Shigella sonnei Ss046 NADH dehydrogenase subunit J YP_311217.1 2466342 R 300269 CDS YP_311218.1 74312799 3668512 complement(2466908..2467450) 1 NC_007384.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 2467450 nuoI 3668512 nuoI Shigella sonnei Ss046 NADH dehydrogenase subunit I YP_311218.1 2466908 R 300269 CDS YP_311219.1 74312800 3668513 complement(2467465..2468442) 1 NC_007384.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 2468442 nuoH 3668513 nuoH Shigella sonnei Ss046 NADH dehydrogenase subunit H YP_311219.1 2467465 R 300269 CDS YP_311220.1 74312801 3668514 complement(2468439..2471171) 1 NC_007384.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 2471171 nuoG 3668514 nuoG Shigella sonnei Ss046 NADH dehydrogenase subunit G YP_311220.1 2468439 R 300269 CDS YP_311221.1 74312802 3668515 complement(2471218..2472555) 1 NC_007384.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F 2472555 nuoF 3668515 nuoF Shigella sonnei Ss046 NADH dehydrogenase I subunit F YP_311221.1 2471218 R 300269 CDS YP_311222.1 74312803 3668516 complement(2472552..2473052) 1 NC_007384.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 2473052 nuoE 3668516 nuoE Shigella sonnei Ss046 NADH dehydrogenase subunit E YP_311222.1 2472552 R 300269 CDS YP_311223.1 74312804 3668517 complement(2473055..2474857) 1 NC_007384.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; NADH:ubiquinone oxidoreductase subunit C/D 2474857 nuoC 3668517 nuoC Shigella sonnei Ss046 NADH:ubiquinone oxidoreductase subunit C/D YP_311223.1 2473055 R 300269 CDS YP_311224.1 74312805 3668518 complement(2474951..2475613) 1 NC_007384.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 2475613 nuoB 3668518 nuoB Shigella sonnei Ss046 NADH dehydrogenase subunit B YP_311224.1 2474951 R 300269 CDS YP_311225.1 74312806 3668519 complement(2475629..2476072) 1 NC_007384.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 2476072 nuoA 3668519 nuoA Shigella sonnei Ss046 NADH dehydrogenase subunit A YP_311225.1 2475629 R 300269 CDS YP_311226.1 74312807 3668520 complement(2476701..2477639) 1 NC_007384.1 Code: K; COG: COG0583; LysR family transcriptional regulator 2477639 lrhA 3668520 lrhA Shigella sonnei Ss046 LysR family transcriptional regulator YP_311226.1 2476701 R 300269 CDS YP_311227.1 74312808 3668521 2478554..2479771 1 NC_007384.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 2479771 3668521 SSON_2347 Shigella sonnei Ss046 aminotransferase YP_311227.1 2478554 D 300269 CDS YP_311228.1 74312809 3668522 2479855..2480454 1 NC_007384.1 Code: R; COG: COG1896; hypothetical protein 2480454 3668522 SSON_2348 Shigella sonnei Ss046 hypothetical protein YP_311228.1 2479855 D 300269 CDS YP_311229.1 74312810 3668523 complement(2480513..2482345) 1 NC_007384.1 Code: P; COG: COG0471; transporter 2482345 yfbS 3668523 yfbS Shigella sonnei Ss046 transporter YP_311229.1 2480513 R 300269 CDS YP_311230.2 161986493 3668525 complement(2483091..2483585) 1 NC_007384.1 Code: S; COG: COG3013; hypothetical protein 2483585 3668525 SSON_2351 Shigella sonnei Ss046 hypothetical protein YP_311230.2 2483091 R 300269 CDS YP_311231.1 74312812 3667466 complement(2483668..2484123) 1 NC_007384.1 Code: S; COG: COG3092; hypothetical protein 2484123 3667466 SSON_2352 Shigella sonnei Ss046 hypothetical protein YP_311231.1 2483668 R 300269 CDS YP_311232.1 74312813 3667467 2484461..2485663 1 NC_007384.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2485663 ackA 3667467 ackA Shigella sonnei Ss046 acetate kinase YP_311232.1 2484461 D 300269 CDS YP_311233.1 74312814 3667468 2485738..2487882 1 NC_007384.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 2487882 pta 3667468 pta Shigella sonnei Ss046 phosphate acetyltransferase YP_311233.1 2485738 D 300269 CDS YP_311234.2 161986492 3667469 2488072..2489592 1 NC_007384.1 Code: S; COG: COG1288; hypothetical protein 2489592 yfcC 3667469 yfcC Shigella sonnei Ss046 hypothetical protein YP_311234.2 2488072 D 300269 CDS YP_311235.1 74312816 3667470 complement(2489625..2490167) 1 NC_007384.1 Code: LR; COG: COG0494; regulator 2490167 3667470 SSON_2356 Shigella sonnei Ss046 regulator YP_311235.1 2489625 R 300269 CDS YP_311236.1 74312817 3667471 complement(2490225..2490779) 1 NC_007384.1 Code: R; COG: COG0622; phosphodiesterase 2490779 yfcE 3667471 yfcE Shigella sonnei Ss046 phosphodiesterase YP_311236.1 2490225 R 300269 CDS YP_311237.1 74312818 3667472 complement(2490832..2491476) 1 NC_007384.1 Code: O; COG: COG0625; hypothetical protein 2491476 yfcF 3667472 yfcF Shigella sonnei Ss046 hypothetical protein YP_311237.1 2490832 R 300269 CDS YP_311238.1 74312819 3667473 2491612..2492259 1 NC_007384.1 Code: O; COG: COG0625; glutathione S-transferase 2492259 yfcG 3667473 yfcG Shigella sonnei Ss046 glutathione S-transferase YP_311238.1 2491612 D 300269 CDS YP_311239.1 74312820 3667474 2492316..2492678 1 NC_007384.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 2492678 folX 3667474 folX Shigella sonnei Ss046 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase YP_311239.1 2492316 D 300269 CDS YP_311240.1 74312821 3667475 2492699..2493592 1 NC_007384.1 Code: R; COG: COG1090; sugar nucleotide epimerase 2493592 3667475 SSON_2361 Shigella sonnei Ss046 sugar nucleotide epimerase YP_311240.1 2492699 D 300269 CDS YP_311241.1 74312822 3667476 complement(2494486..2494989) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2494989 3667476 SSON_2362 Shigella sonnei Ss046 IS1 ORF YP_311241.1 2494486 R 300269 CDS YP_311242.1 74312823 3667478 complement(2495504..2496277) 1 NC_007384.1 Code: E; COG: COG4598; histidine/lysine/arginine/ornithine transporter subunit 2496277 hisP 3667478 hisP Shigella sonnei Ss046 histidine/lysine/arginine/ornithine transporter subunit YP_311242.1 2495504 R 300269 CDS YP_311243.1 74312824 3667479 complement(2496285..2497001) 1 NC_007384.1 Code: E; COG: COG4160; histidine transport, membrane protein M 2497001 hisM 3667479 hisM Shigella sonnei Ss046 histidine transport, membrane protein M YP_311243.1 2496285 R 300269 CDS YP_311244.1 74312825 3667480 complement(2496998..2497684) 1 NC_007384.1 Code: E; COG: COG4215; histidine transport system permease 2497684 hisQ 3667480 hisQ Shigella sonnei Ss046 histidine transport system permease YP_311244.1 2496998 R 300269 CDS YP_311245.1 74312826 3667481 complement(2497774..2498556) 1 NC_007384.1 Code: ET; COG: COG0834; high-affinity histidine transport system histidine-binding periplasmic protein 2498556 hisJ 3667481 hisJ Shigella sonnei Ss046 high-affinity histidine transport system histidine-binding periplasmic protein YP_311245.1 2497774 R 300269 CDS YP_311246.1 74312827 3667482 complement(2498777..2499559) 1 NC_007384.1 Code: ET; COG: COG0834; lysine-, arginine-, ornithine-binding periplasmic protein 2499559 argT 3667482 argT Shigella sonnei Ss046 lysine-, arginine-, ornithine-binding periplasmic protein YP_311246.1 2498777 R 300269 CDS YP_311247.1 74312828 3667483 complement(2499825..2500394) 1 NC_007384.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 2500394 ubiX 3667483 ubiX Shigella sonnei Ss046 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_311247.1 2499825 R 300269 CDS YP_311248.1 74312829 3667484 complement(2500489..2502006) 1 NC_007384.1 PRPP amidotransferase; Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 2502006 purF 3667484 purF Shigella sonnei Ss046 amidophosphoribosyltransferase YP_311248.1 2500489 R 300269 CDS YP_311249.1 74312830 3667485 complement(2502043..2502531) 1 NC_007384.1 membrane protein required for colicin V production; colicin V production protein 2502531 cvpA 3667485 cvpA Shigella sonnei Ss046 colicin V production protein YP_311249.1 2502043 R 300269 CDS YP_311250.2 161986491 3667080 complement(2502790..2503452) 1 NC_007384.1 Code: S; COG: COG3147; hypothetical protein 2503452 dedD 3667080 dedD Shigella sonnei Ss046 hypothetical protein YP_311250.2 2502790 R 300269 CDS YP_311251.1 74312832 3667081 complement(2503442..2504710) 1 NC_007384.1 dihydrofolate synthetase; Code: H; COG: COG0285; bifunctional folylpolyglutamate synthase/dihydrofolate synthase 2504710 folC 3667081 folC Shigella sonnei Ss046 bifunctional folylpolyglutamate synthase/dihydrofolate synthase YP_311251.1 2503442 R 300269 CDS YP_311252.1 74312833 3667082 complement(2504780..2505694) 1 NC_007384.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 2505694 accD 3667082 accD Shigella sonnei Ss046 acetyl-CoA carboxylase subunit beta YP_311252.1 2504780 R 300269 CDS YP_311253.1 74312834 3667083 complement(2505850..2506509) 1 NC_007384.1 Code: S; COG: COG0586; hypothetical protein 2506509 dedA 3667083 dedA Shigella sonnei Ss046 hypothetical protein YP_311253.1 2505850 R 300269 CDS YP_311254.1 74312835 3667084 complement(2506592..2507404) 1 NC_007384.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 2507404 truA 3667084 truA Shigella sonnei Ss046 tRNA pseudouridine synthase A YP_311254.1 2506592 R 300269 CDS YP_311255.1 74312836 3667085 complement(2507404..2508417) 1 NC_007384.1 Code: E; COG: COG0136; semialdehyde dehydrogenase 2508417 usg 3667085 usg Shigella sonnei Ss046 semialdehyde dehydrogenase YP_311255.1 2507404 R 300269 CDS YP_311256.1 74312837 3667086 complement(2508483..2509619) 1 NC_007384.1 Code: HE; COG: COG0111; erythronate-4-phosphate dehydrogenase 2509619 pdxB 3667086 pdxB Shigella sonnei Ss046 erythronate-4-phosphate dehydrogenase YP_311256.1 2508483 R 300269 CDS YP_311257.1 74312838 3667087 2509718..2510713 1 NC_007384.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 2510713 flk 3667087 flk Shigella sonnei Ss046 flagella biosynthesis regulator YP_311257.1 2509718 D 300269 CDS YP_311258.1 74312839 3667088 complement(2510710..2511888) 1 NC_007384.1 Code: GEPR; COG: COG0477; hypothetical protein 2511888 3667088 SSON_2380 Shigella sonnei Ss046 hypothetical protein YP_311258.1 2510710 R 300269 CDS YP_311259.1 74312840 3667089 complement(2512163..2513383) 1 NC_007384.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 2513383 fabB 3667089 fabB Shigella sonnei Ss046 3-oxoacyl-ACP synthase YP_311259.1 2512163 R 300269 CDS YP_311260.2 161986490 3667090 2513542..2515548 1 NC_007384.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 2515548 mnmC 3667090 mnmC Shigella sonnei Ss046 5-methylaminomethyl-2-thiouridine methyltransferase YP_311260.2 2513542 D 300269 CDS YP_311261.1 74312842 3667091 complement(2515669..2515947) 1 NC_007384.1 hypothetical protein 2515947 3667091 SSON_2383 Shigella sonnei Ss046 hypothetical protein YP_311261.1 2515669 R 300269 CDS YP_311262.1 74312843 3667092 complement(2515981..2516529) 1 NC_007384.1 Code: S; COG: COG3101; transporting ATPase 2516529 3667092 SSON_2384 Shigella sonnei Ss046 transporting ATPase YP_311262.1 2515981 R 300269 CDS YP_311263.1 74312844 3667093 complement(2516529..2517338) 1 NC_007384.1 Code: R; COG: COG0730; hypothetical protein 2517338 yfcA 3667093 yfcA Shigella sonnei Ss046 hypothetical protein YP_311263.1 2516529 R 300269 CDS YP_311264.1 74312845 3667094 complement(2517338..2518162) 1 NC_007384.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 2518162 mepA 3667094 mepA Shigella sonnei Ss046 penicillin-insensitive murein endopeptidase YP_311264.1 2517338 R 300269 CDS YP_311265.1 74312846 3667095 complement(2518166..2519251) 1 NC_007384.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 2519251 aroC 3667095 aroC Shigella sonnei Ss046 chorismate synthase YP_311265.1 2518166 R 300269 CDS YP_311266.1 74312848 3667097 complement(2519286..2520551) 1 NC_007384.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 2520551 yfcB 3667097 yfcB Shigella sonnei Ss046 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_311266.1 2519286 R 300269 CDS YP_311267.1 74312847 3667096 2520384..2520935 1 NC_007384.1 Code: S; COG: COG2840; hypothetical protein 2520935 3667096 SSON_2388 Shigella sonnei Ss046 hypothetical protein YP_311267.1 2520384 D 300269 CDS YP_311268.1 74312849 3667098 complement(2521057..2521824) 1 NC_007384.1 hypothetical protein 2521824 yfcO 3667098 yfcO Shigella sonnei Ss046 hypothetical protein YP_311268.1 2521057 R 300269 CDS YP_311269.1 74312850 3667099 complement(2521916..2522440) 1 NC_007384.1 Code: NU; COG: COG3539; minor fimbrial subunit 2522440 3667099 SSON_2391 Shigella sonnei Ss046 minor fimbrial subunit YP_311269.1 2521916 R 300269 CDS YP_311270.1 74312851 3667100 complement(2522437..2522907) 1 NC_007384.1 Code: NU; COG: COG3539; minor fimbrial subunit 2522907 3667100 SSON_2392 Shigella sonnei Ss046 minor fimbrial subunit YP_311270.1 2522437 R 300269 CDS YP_311271.1 74312852 3667101 complement(2523427..2524071) 1 NC_007384.1 Code: NU; COG: COG3121; chaperone 2524071 yfcS 3667101 yfcS Shigella sonnei Ss046 chaperone YP_311271.1 2523427 R 300269 CDS YP_311272.1 74312853 3667102 complement(2524198..2526840) 1 NC_007384.1 involved in fimbrial biogenesis; Code: NU; COG: COG3188; PapC-like porin protein 2526840 yfcU 3667102 yfcU Shigella sonnei Ss046 PapC-like porin protein YP_311272.1 2524198 R 300269 CDS YP_311273.1 74312854 3667103 complement(2526922..2527485) 1 NC_007384.1 Code: NU; COG: COG3539; fimbrial-like protein 2527485 3667103 SSON_2395 Shigella sonnei Ss046 fimbrial-like protein YP_311273.1 2526922 R 300269 CDS YP_311274.1 74312855 3667104 complement(2528169..2528654) 1 NC_007384.1 Code: T; COG: COG2062; phosphohistidine phosphatase 2528654 3667104 SSON_2396 Shigella sonnei Ss046 phosphohistidine phosphatase YP_311274.1 2528169 R 300269 CDS YP_311275.1 74312856 3667105 complement(2528857..2531001) 1 NC_007384.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha 2531001 fadJ 3667105 fadJ Shigella sonnei Ss046 multifunctional fatty acid oxidation complex subunit alpha YP_311275.1 2528857 R 300269 CDS YP_311276.1 74312857 3667106 complement(2531001..2532311) 1 NC_007384.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase 2532311 fadI 3667106 fadI Shigella sonnei Ss046 3-ketoacyl-CoA thiolase YP_311276.1 2531001 R 300269 CDS YP_311277.1 74312858 3667107 complement(2532491..2532799) 1 NC_007384.1 Code: S; COG: COG3691; hypothetical protein 2532799 3667107 SSON_2399 Shigella sonnei Ss046 hypothetical protein YP_311277.1 2532491 R 300269 CDS YP_311278.1 74312859 3667108 2533141..2534487 1 NC_007384.1 Code: I; COG: COG2067; long-chain fatty acid outer membrane transporter 2534487 fadL 3667108 fadL Shigella sonnei Ss046 long-chain fatty acid outer membrane transporter YP_311278.1 2533141 D 300269 CDS YP_311279.1 74312860 3667109 2534953..2536149 1 NC_007384.1 Code: L; COG: COG3547; ISSfl2 ORF 2536149 3667109 SSON_2401 Shigella sonnei Ss046 ISSfl2 ORF YP_311279.1 2534953 D 300269 CDS YP_311280.1 74312861 3667110 complement(2536277..2536780) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2536780 3667110 SSON_2402 Shigella sonnei Ss046 IS1 ORF YP_311280.1 2536277 R 300269 CDS YP_311281.1 74312862 3667111 complement(2538329..2539084) 1 NC_007384.1 Code: M; COG: COG2853; lipoprotein 2539084 vacJ 3667111 vacJ Shigella sonnei Ss046 lipoprotein YP_311281.1 2538329 R 300269 CDS YP_311282.1 74312863 3667112 2539378..2540310 1 NC_007384.1 Code: P; COG: COG2116; transport 2540310 yfdC 3667112 yfdC Shigella sonnei Ss046 transport YP_311282.1 2539378 D 300269 CDS YP_311283.1 74312864 3667114 2540622..2541779 1 NC_007384.1 Code: L; COG: COG0582; prophage Sf6-like integrase 2541779 intC 3667114 intC Shigella sonnei Ss046 prophage Sf6-like integrase YP_311283.1 2540622 D 300269 CDS YP_311284.1 74312865 3667115 2542088..2542441 1 NC_007384.1 Code: L; COG: COG2801; IS2 ORF2 2542441 3667115 SSON_2407 Shigella sonnei Ss046 IS2 ORF2 YP_311284.1 2542088 D 300269 CDS YP_311285.1 74312866 3667116 complement(2543256..2543759) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2543759 3667116 SSON_2408 Shigella sonnei Ss046 IS1 ORF YP_311285.1 2543256 R 300269 CDS YP_311286.1 74312867 3667447 complement(2545274..2548363) 1 NC_007384.1 phage protein-like protein 2548363 3667447 SSON_2410 Shigella sonnei Ss046 phage protein-like protein YP_311286.1 2545274 R 300269 CDS YP_311287.1 74312868 3667448 complement(2548456..2548938) 1 NC_007384.1 Code: M; COG: COG3637; outer membrane protein 2548938 3667448 SSON_2411 Shigella sonnei Ss046 outer membrane protein YP_311287.1 2548456 R 300269 CDS YP_311288.1 74312869 3667449 complement(2549009..2552506) 1 NC_007384.1 Code: S; COG: COG4733; host specificity protein 2552506 3667449 SSON_2412 Shigella sonnei Ss046 host specificity protein YP_311288.1 2549009 R 300269 CDS YP_311289.1 74312870 3667450 complement(2552567..2553199) 1 NC_007384.1 Code: S; COG: COG4723; prophage tail protein 2553199 3667450 SSON_2413 Shigella sonnei Ss046 prophage tail protein YP_311289.1 2552567 R 300269 CDS YP_311290.1 74312871 3667451 complement(2553136..2553879) 1 NC_007384.1 Code: M; COG: COG0791; tail assembly protein 2553879 3667451 SSON_2414 Shigella sonnei Ss046 tail assembly protein YP_311290.1 2553136 R 300269 CDS YP_311291.1 74312872 3667452 complement(2553885..2554583) 1 NC_007384.1 Code: S; COG: COG4672; minor tail protein 2554583 3667452 SSON_2415 Shigella sonnei Ss046 minor tail protein YP_311291.1 2553885 R 300269 CDS YP_311292.1 74312873 3667453 complement(2554583..2554912) 1 NC_007384.1 Code: S; COG: COG4718; minor tail protein 2554912 3667453 SSON_2416 Shigella sonnei Ss046 minor tail protein YP_311292.1 2554583 R 300269 CDS YP_311293.1 74312874 3667454 complement(2554909..2557470) 1 NC_007384.1 Code: S; COG: COG5281; tail length tape measure protein 2557470 3667454 SSON_2417 Shigella sonnei Ss046 tail length tape measure protein YP_311293.1 2554909 R 300269 CDS YP_311294.1 74312875 3667455 complement(2557463..2557897) 1 NC_007384.1 prophage tail protein 2557897 3667455 SSON_2418 Shigella sonnei Ss046 prophage tail protein YP_311294.1 2557463 R 300269 CDS YP_311295.1 74312876 3667456 complement(2557879..2558301) 1 NC_007384.1 prophage tail protein 2558301 3667456 SSON_2419 Shigella sonnei Ss046 prophage tail protein YP_311295.1 2557879 R 300269 CDS YP_311296.1 74312877 3667457 complement(2558317..2559057) 1 NC_007384.1 Code: N; COG: COG5492; prophage tail protein 2559057 3667457 SSON_2420 Shigella sonnei Ss046 prophage tail protein YP_311296.1 2558317 R 300269 CDS YP_311297.1 74312878 3667458 complement(2559065..2559460) 1 NC_007384.1 prophage tail protein 2559460 3667458 SSON_2421 Shigella sonnei Ss046 prophage tail protein YP_311297.1 2559065 R 300269 CDS YP_311298.1 74312879 3667459 complement(2559457..2560035) 1 NC_007384.1 prophage tail protein 2560035 3667459 SSON_2422 Shigella sonnei Ss046 prophage tail protein YP_311298.1 2559457 R 300269 CDS YP_311299.1 74312880 3667460 complement(2560047..2560400) 1 NC_007384.1 head-tail joining protein of prophage 2560400 3667460 SSON_2423 Shigella sonnei Ss046 head-tail joining protein of prophage YP_311299.1 2560047 R 300269 CDS YP_311300.1 74312881 3667461 complement(2560412..2560810) 1 NC_007384.1 DNA-packaging protein 2560810 3667461 SSON_2424 Shigella sonnei Ss046 DNA-packaging protein YP_311300.1 2560412 R 300269 CDS YP_311301.1 74312882 3667462 complement(2560852..2561877) 1 NC_007384.1 major capsid protein 2561877 3667462 SSON_2425 Shigella sonnei Ss046 major capsid protein YP_311301.1 2560852 R 300269 CDS YP_311302.1 74312883 3667463 complement(2561933..2562265) 1 NC_007384.1 head decoration protein 2562265 3667463 SSON_2426 Shigella sonnei Ss046 head decoration protein YP_311302.1 2561933 R 300269 CDS YP_311303.1 74312884 3667464 complement(2562275..2563555) 1 NC_007384.1 Code: OU; COG: COG0616; minor capsid protein 2563555 3667464 SSON_2427 Shigella sonnei Ss046 minor capsid protein YP_311303.1 2562275 R 300269 CDS YP_311304.1 74312885 3667465 complement(2563575..2565176) 1 NC_007384.1 Code: R; COG: COG5511; capsid structural protein of prophage 2565176 3667465 SSON_2428 Shigella sonnei Ss046 capsid structural protein of prophage YP_311304.1 2563575 R 300269 CDS YP_311305.1 74312886 3668579 complement(2565173..2565379) 1 NC_007384.1 head-tail joining protein of prophage 2565379 3668579 SSON_2429 Shigella sonnei Ss046 head-tail joining protein of prophage YP_311305.1 2565173 R 300269 CDS YP_311306.1 74312887 3668580 complement(2565376..2567301) 1 NC_007384.1 Code: R; COG: COG5525; DNA packaging protein of prophage 2567301 3668580 SSON_2430 Shigella sonnei Ss046 DNA packaging protein of prophage YP_311306.1 2565376 R 300269 CDS YP_311307.1 74312888 3668581 complement(2567276..2567821) 1 NC_007384.1 Code: L; COG: COG4220; bacteriophage DNA packaging protein 2567821 nohB 3668581 nohB Shigella sonnei Ss046 bacteriophage DNA packaging protein YP_311307.1 2567276 R 300269 CDS YP_311308.1 74312889 3668582 2568486..2568911 1 NC_007384.1 Code: R; COG: COG5562; hypothetical protein 2568911 ydfO 3668582 ydfO Shigella sonnei Ss046 hypothetical protein YP_311308.1 2568486 D 300269 CDS YP_311309.2 161986489 3668583 complement(2569091..2569996) 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2569996 3668583 SSON_2433 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_311309.2 2569091 R 300269 CDS YP_311310.1 74312891 3668584 complement(2569954..2570319) 1 NC_007384.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 2570319 3668584 SSON_2434 Shigella sonnei Ss046 insertion sequence 2 OrfA protein YP_311310.1 2569954 R 300269 CDS YP_311311.1 74312892 3668585 complement(2570836..2571093) 1 NC_007384.1 bacteriophage protein 2571093 3668585 SSON_2435 Shigella sonnei Ss046 bacteriophage protein YP_311311.1 2570836 R 300269 CDS YP_311312.1 74312893 3668586 complement(2571789..2572247) 1 NC_007384.1 endopeptidase 2572247 3668586 SSON_2436 Shigella sonnei Ss046 endopeptidase YP_311312.1 2571789 R 300269 CDS YP_311313.1 74312894 3668587 complement(2572244..2572741) 1 NC_007384.1 Code: R; COG: COG3772; lysozyme 2572741 3668587 SSON_2437 Shigella sonnei Ss046 lysozyme YP_311313.1 2572244 R 300269 CDS YP_311314.1 74312895 3668588 complement(2572741..2572956) 1 NC_007384.1 hypothetical protein 2572956 ybcR 3668588 ybcR Shigella sonnei Ss046 hypothetical protein YP_311314.1 2572741 R 300269 CDS YP_311315.1 74312896 3668589 2573396..2573899 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2573899 3668589 SSON_2439 Shigella sonnei Ss046 IS1 ORF YP_311315.1 2573396 D 300269 CDS YP_311316.1 74312897 3668590 2574305..2575387 1 NC_007384.1 Code: M; COG: COG3203; porin 2575387 nmpC 3668590 nmpC Shigella sonnei Ss046 porin YP_311316.1 2574305 D 300269 CDS YP_311317.1 74312898 3668591 complement(2575576..2575959) 1 NC_007384.1 hypothetical protein 2575959 ybcQ 3668591 ybcQ Shigella sonnei Ss046 hypothetical protein YP_311317.1 2575576 R 300269 CDS YP_311318.1 74312899 3668592 complement(2576045..2576182) 1 NC_007384.1 hypothetical protein 2576182 3668592 SSON_2442 Shigella sonnei Ss046 hypothetical protein YP_311318.1 2576045 R 300269 CDS YP_311319.1 74312900 3668593 complement(2576182..2576544) 1 NC_007384.1 Holliday junction resolvase; DLP12 prophage; Holliday junction resolvase; endodeoxyribonuclease RUS 2576544 rus 3668593 rus Shigella sonnei Ss046 endodeoxyribonuclease RUS YP_311319.1 2576182 R 300269 CDS YP_311320.1 74312901 3668594 complement(2576541..2576831) 1 NC_007384.1 hypothetical protein 2576831 ybcO 3668594 ybcO Shigella sonnei Ss046 hypothetical protein YP_311320.1 2576541 R 300269 CDS YP_311321.1 74312902 3668595 complement(2576824..2576994) 1 NC_007384.1 similar to phage 82 and lambda proteins; DLP12 prophage; conserved protein similar to phage 82 and lambda proteins; prophage protein NinE 2576994 ninE 3668595 ninE Shigella sonnei Ss046 prophage protein NinE YP_311321.1 2576824 R 300269 CDS YP_311322.1 74312903 3668596 complement(2576994..2577449) 1 NC_007384.1 DLP12 prophage; hypothetical protein 2577449 ybcN 3668596 ybcN Shigella sonnei Ss046 hypothetical protein YP_311322.1 2576994 R 300269 CDS YP_311323.1 74312904 3668597 2578955..2580115 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 2580115 3668597 SSON_2447 Shigella sonnei Ss046 IS21 ORF1 YP_311323.1 2578955 D 300269 CDS YP_311324.1 74312905 3668598 2580128..2580925 1 NC_007384.1 Code: L; COG: COG1484; IS21 ORF2 2580925 3668598 SSON_2448 Shigella sonnei Ss046 IS21 ORF2 YP_311324.1 2580128 D 300269 CDS YP_311325.1 74312906 3668811 2581007..2581510 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2581510 3668811 SSON_2449 Shigella sonnei Ss046 IS1 ORF YP_311325.1 2581007 D 300269 CDS YP_311326.1 74312907 3668812 2581659..2582906 1 NC_007384.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease 2582906 lacY 3668812 lacY Shigella sonnei Ss046 galactoside permease YP_311326.1 2581659 D 300269 CDS YP_311327.1 74312908 3668813 complement(2585110..2585613) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2585613 3668813 SSON_2451 Shigella sonnei Ss046 IS1 ORF YP_311327.1 2585110 R 300269 CDS YP_311328.1 74312909 3668814 complement(2586162..2587001) 1 NC_007384.1 Code: L; COG: COG2801; IS911 ORF2 2587001 3668814 SSON_2452 Shigella sonnei Ss046 IS911 ORF2 YP_311328.1 2586162 R 300269 CDS YP_311329.1 74312910 3668815 2587876..2589222 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 2589222 3668815 SSON_2453 Shigella sonnei Ss046 IS4 orf YP_311329.1 2587876 D 300269 CDS YP_311330.1 74312911 3668816 2589467..2590900 1 NC_007384.1 Code: G; COG: COG1621; sucrose hydrolase 2590900 3668816 SSON_2454 Shigella sonnei Ss046 sucrose hydrolase YP_311330.1 2589467 D 300269 CDS YP_311331.1 74312912 3668817 complement(2590908..2591861) 1 NC_007384.1 Code: K; COG: COG1609; sucrose operon repressor 2591861 3668817 SSON_2455 Shigella sonnei Ss046 sucrose operon repressor YP_311331.1 2590908 R 300269 CDS YP_311332.1 74312913 3668818 2592134..2592352 1 NC_007384.1 D-serine permease 2592352 3668818 SSON_2456 Shigella sonnei Ss046 D-serine permease YP_311332.1 2592134 D 300269 CDS YP_311333.1 74312914 3668819 2592370..2593698 1 NC_007384.1 deaminase; catalyzes the formation of pyruvate from serine; D-serine dehydratase 2593698 dsdA 3668819 dsdA Shigella sonnei Ss046 D-serine dehydratase YP_311333.1 2592370 D 300269 CDS YP_311334.1 74312915 3668820 complement(2593806..2595344) 1 NC_007384.1 Code: GEPR; COG: COG0477; multidrug resistance protein Y 2595344 emrY 3668820 emrY Shigella sonnei Ss046 multidrug resistance protein Y YP_311334.1 2593806 R 300269 CDS YP_311335.1 74312916 3668821 complement(2595344..2596507) 1 NC_007384.1 Code: V; COG: COG1566; multidrug resistance protein K 2596507 emrK 3668821 emrK Shigella sonnei Ss046 multidrug resistance protein K YP_311335.1 2595344 R 300269 CDS YP_311336.1 74312917 3668822 2596923..2597537 1 NC_007384.1 response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; DNA-binding transcriptional activator EvgA 2597537 evgA 3668822 evgA Shigella sonnei Ss046 DNA-binding transcriptional activator EvgA YP_311336.1 2596923 D 300269 CDS YP_311337.1 74312918 3668823 2597542..2601135 1 NC_007384.1 Code: ET; COG: COG0834; hybrid sensory histidine kinase in two-component regulatory system with EvgA 2601135 evgS 3668823 evgS Shigella sonnei Ss046 hybrid sensory histidine kinase in two-component regulatory system with EvgA YP_311337.1 2597542 D 300269 CDS YP_311338.1 74312919 3668824 complement(2601191..2602375) 1 NC_007384.1 Code: C; COG: COG1804; hypothetical protein 2602375 yfdE 3668824 yfdE Shigella sonnei Ss046 hypothetical protein YP_311338.1 2601191 R 300269 CDS YP_311339.1 74312920 3668825 complement(2602410..2603354) 1 NC_007384.1 member of the AEC family of auxin efflux transporters; unknown function; transporter YfdV 2603354 3668825 SSON_2463 Shigella sonnei Ss046 transporter YfdV YP_311339.1 2602410 R 300269 CDS YP_311340.1 74312921 3668826 complement(2603424..2605118) 1 NC_007384.1 catalyzes the formation of formyl-CoA from oxalyl-CoA; oxalyl-CoA decarboxylase 2605118 3668826 SSON_2464 Shigella sonnei Ss046 oxalyl-CoA decarboxylase YP_311340.1 2603424 R 300269 CDS YP_311341.1 74312922 3668827 complement(2605172..2606422) 1 NC_007384.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase 2606422 3668827 SSON_2465 Shigella sonnei Ss046 formyl-coenzyme A transferase YP_311341.1 2605172 R 300269 CDS YP_311342.1 74312923 3668828 complement(2606935..2607558) 1 NC_007384.1 hypothetical protein 2607558 3668828 SSON_2466 Shigella sonnei Ss046 hypothetical protein YP_311342.1 2606935 R 300269 CDS YP_311343.1 74312924 3668829 2607855..2608130 1 NC_007384.1 hypothetical protein 2608130 3668829 SSON_2467 Shigella sonnei Ss046 hypothetical protein YP_311343.1 2607855 D 300269 CDS YP_311344.1 74312925 3668886 complement(2608207..2608449) 1 NC_007384.1 hypothetical protein 2608449 yfdY 3668886 yfdY Shigella sonnei Ss046 hypothetical protein YP_311344.1 2608207 R 300269 CDS YP_311345.2 161986488 3668887 2608802..2609722 1 NC_007384.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 2609722 ddg 3668887 ddg Shigella sonnei Ss046 lipid A biosynthesis palmitoleoyl acyltransferase YP_311345.2 2608802 D 300269 CDS YP_311346.1 74312927 3668888 complement(2610214..2611452) 1 NC_007384.1 Code: E; COG: COG0436; aminotransferase 2611452 3668888 SSON_2470 Shigella sonnei Ss046 aminotransferase YP_311346.1 2610214 R 300269 CDS YP_311347.1 74312928 3668890 2612648..2613151 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2613151 3668890 SSON_2472 Shigella sonnei Ss046 IS1 ORF YP_311347.1 2612648 D 300269 CDS YP_311348.1 74312929 3668891 2614318..2615052 1 NC_007384.1 Code: KT; COG: COG3279; 2-component transcriptional regulator 2615052 3668891 SSON_2473 Shigella sonnei Ss046 2-component transcriptional regulator YP_311348.1 2614318 D 300269 CDS YP_311349.1 74312930 3668892 2615065..2615922 1 NC_007384.1 Code: K; COG: COG2207; AraC family transcriptional regulator 2615922 3668892 SSON_2474 Shigella sonnei Ss046 AraC family transcriptional regulator YP_311349.1 2615065 D 300269 CDS YP_311350.1 74312931 3668894 complement(2618445..2619482) 1 NC_007384.1 metalloprotein; exoaminopeptidase 2619482 3668894 SSON_2476 Shigella sonnei Ss046 exoaminopeptidase YP_311350.1 2618445 R 300269 CDS YP_311351.1 74312932 3668896 complement(2620582..2621829) 1 NC_007384.1 Code: G; COG: COG1299; transporter 2621829 3668896 SSON_2478 Shigella sonnei Ss046 transporter YP_311351.1 2620582 R 300269 CDS YP_311352.1 74312933 3668897 complement(2621851..2622177) 1 NC_007384.1 Code: G; COG: COG1445; PTS system transporter subunit IIB 2622177 3668897 SSON_2479 Shigella sonnei Ss046 PTS system transporter subunit IIB YP_311352.1 2621851 R 300269 CDS YP_311353.1 74312934 3668898 complement(2622397..2623362) 1 NC_007384.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase 2623362 glk 3668898 glk Shigella sonnei Ss046 glucokinase YP_311353.1 2622397 R 300269 CDS YP_311354.1 74312935 3668899 2623566..2624822 1 NC_007384.1 Code: P; COG: COG0038; hypothetical protein 2624822 3668899 SSON_2481 Shigella sonnei Ss046 hypothetical protein YP_311354.1 2623566 D 300269 CDS YP_311355.1 74312936 3668900 2624937..2625263 1 NC_007384.1 hypothetical protein 2625263 3668900 SSON_2482 Shigella sonnei Ss046 hypothetical protein YP_311355.1 2624937 D 300269 CDS YP_311357.1 74312938 3668902 complement(2625404..2626642) 1 NC_007384.1 Code: P; COG: COG1914; manganese transport protein MntH 2626642 3668902 SSON_2484 Shigella sonnei Ss046 manganese transport protein MntH YP_311357.1 2625404 R 300269 CDS YP_311358.1 74312939 3668903 2626978..2628180 1 NC_007384.1 Code: F; COG: COG1972; permease of transport system for 3 nucleosides 2628180 nupC 3668903 nupC Shigella sonnei Ss046 permease of transport system for 3 nucleosides YP_311358.1 2626978 D 300269 CDS YP_311359.1 74312940 3667621 2631038..2631397 1 NC_007384.1 hypothetical protein 2631397 yfeC 3667621 yfeC Shigella sonnei Ss046 hypothetical protein YP_311359.1 2631038 D 300269 CDS YP_311360.1 74312941 3667622 2631399..2631791 1 NC_007384.1 hypothetical protein 2631791 yfeD 3667622 yfeD Shigella sonnei Ss046 hypothetical protein YP_311360.1 2631399 D 300269 CDS YP_311361.1 74312942 3667623 complement(2631843..2633258) 1 NC_007384.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 2633258 gltX 3667623 gltX Shigella sonnei Ss046 glutamyl-tRNA synthetase YP_311361.1 2631843 R 300269 CDS YP_311362.1 74312943 3667628 2634191..2634532 1 NC_007384.1 hypothetical protein 2634532 flxA 3667628 flxA Shigella sonnei Ss046 hypothetical protein YP_311362.1 2634191 D 300269 CDS YP_311363.1 74312944 3667629 complement(2634523..2635449) 1 NC_007384.1 Code: K; COG: COG0583; LysR family transcriptional regulator 2635449 yfeR 3667629 yfeR Shigella sonnei Ss046 LysR family transcriptional regulator YP_311363.1 2634523 R 300269 CDS YP_311364.1 74312945 3667630 2635539..2636537 1 NC_007384.1 Code: R; COG: COG0385; cytochrome oxidase 2636537 yfeH 3667630 yfeH Shigella sonnei Ss046 cytochrome oxidase YP_311364.1 2635539 D 300269 CDS YP_311365.1 74312946 3667631 complement(2636534..2636752) 1 NC_007384.1 Code: S; COG: COG3530; hypothetical protein 2636752 ypeB 3667631 ypeB Shigella sonnei Ss046 hypothetical protein YP_311365.1 2636534 R 300269 CDS YP_311366.1 74312947 3667632 complement(2636754..2638769) 1 NC_007384.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 2638769 ligA 3667632 ligA Shigella sonnei Ss046 NAD-dependent DNA ligase LigA YP_311366.1 2636754 R 300269 CDS YP_311367.1 74312948 3667653 complement(2638840..2639826) 1 NC_007384.1 involved in FtsZ ring; interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA 2639826 zipA 3667653 zipA Shigella sonnei Ss046 cell division protein ZipA YP_311367.1 2638840 R 300269 CDS YP_311368.1 74312949 3667654 2640056..2640817 1 NC_007384.1 required for sulfate transport; role in sulfur assimilation; sulfate transport protein CysZ 2640817 cysZ 3667654 cysZ Shigella sonnei Ss046 sulfate transport protein CysZ YP_311368.1 2640056 D 300269 CDS YP_311369.1 74312950 3667655 2641002..2641973 1 NC_007384.1 O-acetylserine sulfhydrolase A; CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 2641973 cysK 3667655 cysK Shigella sonnei Ss046 cysteine synthase A YP_311369.1 2641002 D 300269 CDS YP_311370.1 74312951 3667656 2642357..2642614 1 NC_007384.1 Code: G; COG: COG1925; PTS system phosphohistidinoprotein-hexose phosphotransferase Hpr 2642614 ptsH 3667656 ptsH Shigella sonnei Ss046 PTS system phosphohistidinoprotein-hexose phosphotransferase Hpr YP_311370.1 2642357 D 300269 CDS YP_311371.1 74312952 3667657 2642659..2644386 1 NC_007384.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 2644386 ptsI 3667657 ptsI Shigella sonnei Ss046 phosphoenolpyruvate-protein phosphotransferase YP_311371.1 2642659 D 300269 CDS YP_311372.1 74312953 3667658 2644427..2644936 1 NC_007384.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter 2644936 crr 3667658 crr Shigella sonnei Ss046 PTS system glucose-specific transporter YP_311372.1 2644427 D 300269 CDS YP_311373.1 74312954 3667659 2645037..2646383 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 2646383 3667659 SSON_2507 Shigella sonnei Ss046 IS4 orf YP_311373.1 2645037 D 300269 CDS YP_311374.1 74312955 3667660 complement(2646416..2647267) 1 NC_007384.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase 2647267 pdxK 3667660 pdxK Shigella sonnei Ss046 pyridoxal kinase YP_311374.1 2646416 R 300269 CDS YP_311375.1 74312956 3667661 2647372..2647740 1 NC_007384.1 hypothetical protein 2647740 yfeK 3667661 yfeK Shigella sonnei Ss046 hypothetical protein YP_311375.1 2647372 D 300269 CDS YP_311376.1 74312957 3667662 complement(2647743..2648654) 1 NC_007384.1 O-acetylserine sulfhydrolase B; catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B 2648654 cysM 3667662 cysM Shigella sonnei Ss046 cysteine synthase B YP_311376.1 2647743 R 300269 CDS YP_311377.1 74312958 3667663 complement(2648788..2649885) 1 NC_007384.1 chromate resistance; Code: P; COG: COG1118; sulfate/thiosulfate transporter subunit 2649885 cysA 3667663 cysA Shigella sonnei Ss046 sulfate/thiosulfate transporter subunit YP_311377.1 2648788 R 300269 CDS YP_311378.1 74312959 3667664 complement(2649875..2650750) 1 NC_007384.1 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate transporter permease subunit 2650750 cysW 3667664 cysW Shigella sonnei Ss046 sulfate/thiosulfate transporter permease subunit YP_311378.1 2649875 R 300269 CDS YP_311379.1 74312960 3667665 complement(2650750..2651583) 1 NC_007384.1 Code: O; COG: COG0555; sulfate/thiosulfate transporter subunit 2651583 cysU 3667665 cysU Shigella sonnei Ss046 sulfate/thiosulfate transporter subunit YP_311379.1 2650750 R 300269 CDS YP_311380.1 74312961 3667666 complement(2651583..2652599) 1 NC_007384.1 Code: P; COG: COG4150; thiosulfate transporter subunit 2652599 cysP 3667666 cysP Shigella sonnei Ss046 thiosulfate transporter subunit YP_311380.1 2651583 R 300269 CDS YP_311381.2 161986487 3667667 complement(2652770..2653561) 1 NC_007384.1 Code: IQR; COG: COG1028; short chain dehydrogenase 2653561 ucpA 3667667 ucpA Shigella sonnei Ss046 short chain dehydrogenase YP_311381.2 2652770 R 300269 CDS YP_311382.1 74312963 3667668 complement(2653690..2654547) 1 NC_007384.1 Code: K; COG: COG1737; hypothetical protein 2654547 yfeT 3667668 yfeT Shigella sonnei Ss046 hypothetical protein YP_311382.1 2653690 R 300269 CDS YP_311383.1 74312964 3667669 2654711..2655607 1 NC_007384.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 2655607 murQ 3667669 murQ Shigella sonnei Ss046 N-acetylmuramic acid 6-phosphate etherase YP_311383.1 2654711 D 300269 CDS YP_311384.2 161986486 3667671 2657040..2658344 1 NC_007384.1 Code: V; COG: COG1680; hypothetical protein 2658344 3667671 SSON_2519 Shigella sonnei Ss046 hypothetical protein YP_311384.2 2657040 D 300269 CDS YP_311385.1 74312966 3667730 complement(2658402..2659328) 1 NC_007384.1 Code: P; COG: COG2837; hypothetical protein 2659328 3667730 SSON_2520 Shigella sonnei Ss046 hypothetical protein YP_311385.1 2658402 R 300269 CDS YP_311386.1 74312967 3667731 complement(2659397..2659972) 1 NC_007384.1 hypothetical protein 2659972 3667731 SSON_2521 Shigella sonnei Ss046 hypothetical protein YP_311386.1 2659397 R 300269 CDS YP_311387.1 74312968 3667732 complement(2660033..2660488) 1 NC_007384.1 hypothetical protein 2660488 yfeZ 3667732 yfeZ Shigella sonnei Ss046 hypothetical protein YP_311387.1 2660033 R 300269 CDS YP_311388.2 161986485 3667733 complement(2660469..2660894) 1 NC_007384.1 Code: R; COG: COG0456; acetyltransferase 2660894 3667733 SSON_2523 Shigella sonnei Ss046 acetyltransferase YP_311388.2 2660469 R 300269 CDS YP_311389.1 74312970 3667734 2661108..2661977 1 NC_007384.1 Code: M; COG: COG0860; N-acetylmuramoyl-L-alanine amidase 2661977 amiA 3667734 amiA Shigella sonnei Ss046 N-acetylmuramoyl-L-alanine amidase YP_311389.1 2661108 D 300269 CDS YP_311390.1 74312971 3667735 2661981..2662880 1 NC_007384.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 2662880 hemF 3667735 hemF Shigella sonnei Ss046 coproporphyrinogen III oxidase YP_311390.1 2661981 D 300269 CDS YP_311391.1 74312972 3667736 complement(2662886..2663938) 1 NC_007384.1 activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR 2663938 yfeG 3667736 yfeG Shigella sonnei Ss046 transcriptional regulator EutR YP_311391.1 2662886 R 300269 CDS YP_311392.1 74312973 3667737 complement(2663984..2664490) 1 NC_007384.1 Code: QC; COG: COG4577; hypothetical protein 2664490 3667737 SSON_2527 Shigella sonnei Ss046 hypothetical protein YP_311392.1 2663984 R 300269 CDS YP_311393.1 74312974 3667738 complement(2664497..2665156) 1 NC_007384.1 Code: E; COG: COG4816; ethanolamine utilization protein eutL 2665156 3667738 SSON_2528 Shigella sonnei Ss046 ethanolamine utilization protein eutL YP_311393.1 2664497 R 300269 CDS YP_311394.1 74312975 3667739 complement(2665166..2666053) 1 NC_007384.1 catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit 2666053 eutC 3667739 eutC Shigella sonnei Ss046 ethanolamine ammonia-lyase small subunit YP_311394.1 2665166 R 300269 CDS YP_311395.1 74312976 3667741 complement(2667447..2668850) 1 NC_007384.1 ethanolamine utilization protein EutA; reactivating factor for ethanolamine ammonia lyase 2668850 eutA 3667741 eutA Shigella sonnei Ss046 reactivating factor for ethanolamine ammonia lyase YP_311395.1 2667447 R 300269 CDS YP_311396.1 74312977 3667742 complement(2668847..2670073) 1 NC_007384.1 ethanolamine utilization; similar to Salmonella transport protein; Code: E; COG: COG3192; protein EutH 2670073 eutH 3667742 eutH Shigella sonnei Ss046 protein EutH YP_311396.1 2668847 R 300269 CDS YP_311397.1 74312978 3667743 complement(2670390..2671604) 1 NC_007384.1 ethanolamine utilization; similar to Salmonella enzyme, similar to iron-containing alcohol dehydrogenase; Code: C; COG: COG1454; hypothetical protein 2671604 eutG 3667743 eutG Shigella sonnei Ss046 hypothetical protein YP_311397.1 2670390 R 300269 CDS YP_311398.1 74312979 3667744 complement(2671567..2672403) 1 NC_007384.1 ethanolamine utilization; similar to Salmonella protein; Code: E; COG: COG4820; protein EutJ 2672403 eutJ 3667744 eutJ Shigella sonnei Ss046 protein EutJ YP_311398.1 2671567 R 300269 CDS YP_311399.1 74312980 3667745 complement(2672414..2673817) 1 NC_007384.1 ethanolamine utilization; similar to acetaldehyde dehydrogenase; Code: C; COG: COG1012; protein EutE 2673817 eutE 3667745 eutE Shigella sonnei Ss046 protein EutE YP_311399.1 2672414 R 300269 CDS YP_311400.1 74312981 3667746 complement(2673829..2674116) 1 NC_007384.1 Code: QC; COG: COG4576; detox protein 2674116 cchB 3667746 cchB Shigella sonnei Ss046 detox protein YP_311400.1 2673829 R 300269 CDS YP_311401.2 161986484 3667747 complement(2674223..2674516) 1 NC_007384.1 Code: QC; COG: COG4577; detox protein 2674516 cchA 3667747 cchA Shigella sonnei Ss046 detox protein YP_311401.2 2674223 R 300269 CDS YP_311402.1 74312983 3667748 complement(2674555..2675571) 1 NC_007384.1 ethanolamine utilization; similar to Salmonella acetyl/butyryl P transferase; in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 2675571 eutD 3667748 eutD Shigella sonnei Ss046 phosphotransacetylase YP_311402.1 2674555 R 300269 CDS YP_311403.1 74312984 3667749 complement(2675568..2676371) 1 NC_007384.1 Code: E; COG: COG4812; hypothetical protein 2676371 3667749 SSON_2539 Shigella sonnei Ss046 hypothetical protein YP_311403.1 2675568 R 300269 CDS YP_311404.1 74312985 3667769 complement(2676368..2677069) 1 NC_007384.1 Code: E; COG: COG4766; hypothetical protein 2677069 3667769 SSON_2540 Shigella sonnei Ss046 hypothetical protein YP_311404.1 2676368 R 300269 CDS YP_311405.1 74312986 3667770 complement(2677044..2677523) 1 NC_007384.1 Code: E; COG: COG4917; hypothetical protein 2677523 3667770 SSON_2541 Shigella sonnei Ss046 hypothetical protein YP_311405.1 2677044 R 300269 CDS YP_311406.1 74312987 3667771 complement(2677536..2677943) 1 NC_007384.1 Code: E; COG: COG4810; hypothetical protein 2677943 3667771 SSON_2542 Shigella sonnei Ss046 hypothetical protein YP_311406.1 2677536 R 300269 CDS YP_311407.1 74312988 3667772 complement(2678164..2680443) 1 NC_007384.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 2680443 3667772 SSON_2543 Shigella sonnei Ss046 malic enzyme YP_311407.1 2678164 R 300269 CDS YP_311408.1 74312989 3667773 2680732..2681682 1 NC_007384.1 Code: G; COG: COG0176; transaldolase A 2681682 talA 3667773 talA Shigella sonnei Ss046 transaldolase A YP_311408.1 2680732 D 300269 CDS YP_311409.1 74312990 3667774 2681702..2683705 1 NC_007384.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2683705 tktB 3667774 tktB Shigella sonnei Ss046 transketolase YP_311409.1 2681702 D 300269 CDS YP_311410.1 74312991 3667775 complement(2683801..2684844) 1 NC_007384.1 hypothetical protein 2684844 3667775 SSON_2546 Shigella sonnei Ss046 hypothetical protein YP_311410.1 2683801 R 300269 CDS YP_311411.1 74312992 3667776 complement(2684970..2685545) 1 NC_007384.1 Code: LR; COG: COG0494; hypothetical protein 2685545 yffH 3667776 yffH Shigella sonnei Ss046 hypothetical protein YP_311411.1 2684970 R 300269 CDS YP_311412.1 74312993 3667777 complement(2685613..2687592) 1 NC_007384.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit 2687592 yffG 3667777 yffG Shigella sonnei Ss046 oxidoreductase Fe-S binding subunit YP_311412.1 2685613 R 300269 CDS YP_311413.1 74312994 3667778 2687798..2689498 1 NC_007384.1 Code: T; COG: COG3850; nitrate/nitrite sensor protein NarQ 2689498 narQ 3667778 narQ Shigella sonnei Ss046 nitrate/nitrite sensor protein NarQ YP_311413.1 2687798 D 300269 CDS YP_311414.1 74312995 3667779 2689662..2692775 1 NC_007384.1 sensitivity to acriflavine; integral membrane protein; possible efflux pump; Code: V; COG: COG0841; aminoglycoside/multidrug efflux system 2692775 acrD 3667779 acrD Shigella sonnei Ss046 aminoglycoside/multidrug efflux system YP_311414.1 2689662 D 300269 CDS YP_311415.1 74312996 3667780 2693315..2693671 1 NC_007384.1 Code: P; COG: COG1393; hypothetical protein 2693671 yffB 3667780 yffB Shigella sonnei Ss046 hypothetical protein YP_311415.1 2693315 D 300269 CDS YP_311416.1 74312997 3667781 2693675..2694802 1 NC_007384.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2694802 dapE 3667781 dapE Shigella sonnei Ss046 succinyl-diaminopimelate desuccinylase YP_311416.1 2693675 D 300269 CDS YP_311417.2 228861781 3667782 2694830..2695030 1 NC_007384.1 hypothetical protein 2695030 3667782 SSON_2553 Shigella sonnei Ss046 hypothetical protein YP_311417.2 2694830 D 300269 CDS YP_311418.2 161986483 3667783 complement(2695140..2695838) 1 NC_007384.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase 2695838 ypfH 3667783 ypfH Shigella sonnei Ss046 esterase YP_311418.2 2695140 R 300269 CDS YP_311419.1 74313000 3667784 complement(2695912..2697927) 1 NC_007384.1 Code: R; COG: COG1444; hypothetical protein 2697927 ypfI 3667784 ypfI Shigella sonnei Ss046 hypothetical protein YP_311419.1 2695912 R 300269 CDS YP_311420.1 74313001 3667785 complement(2697942..2698790) 1 NC_007384.1 Code: R; COG: COG2321; hypothetical protein 2698790 3667785 SSON_2556 Shigella sonnei Ss046 hypothetical protein YP_311420.1 2697942 R 300269 CDS YP_311421.1 74313002 3667786 complement(2698958..2699671) 1 NC_007384.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazolesuccinocarboxamide synthase 2699671 purC 3667786 purC Shigella sonnei Ss046 phosphoribosylaminoimidazolesuccinocarboxamide synthase YP_311421.1 2698958 R 300269 CDS YP_311422.1 74313003 3667787 complement(2699884..2700921) 1 NC_007384.1 Code: M; COG: COG3317; lipoprotein 2700921 nlpB 3667787 nlpB Shigella sonnei Ss046 lipoprotein YP_311422.1 2699884 R 300269 CDS YP_311423.1 74313004 3667788 complement(2700935..2701813) 1 NC_007384.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 2701813 dapA 3667788 dapA Shigella sonnei Ss046 dihydrodipicolinate synthase YP_311423.1 2700935 R 300269 CDS YP_311424.2 161986482 3667789 2701959..2702531 1 NC_007384.1 negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 2702531 gcvR 3667789 gcvR Shigella sonnei Ss046 glycine cleavage system transcriptional repressor YP_311424.2 2701959 D 300269 CDS YP_311425.1 74313006 3667790 2702531..2703001 1 NC_007384.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 2703001 bcp 3667790 bcp Shigella sonnei Ss046 thioredoxin-dependent thiol peroxidase YP_311425.1 2702531 D 300269 CDS YP_311426.1 74313007 3667791 2703215..2703871 1 NC_007384.1 Code: C; COG: COG1142; hydrogenase 4 Fe-S subunit 2703871 hyfA 3667791 hyfA Shigella sonnei Ss046 hydrogenase 4 Fe-S subunit YP_311426.1 2703215 D 300269 CDS YP_311427.1 74313008 3667792 2703871..2705889 1 NC_007384.1 Code: CP; COG: COG0651; hydrogenase 4 subunit B 2705889 hyfB 3667792 hyfB Shigella sonnei Ss046 hydrogenase 4 subunit B YP_311427.1 2703871 D 300269 CDS YP_311428.1 74313009 3667793 2705879..2706847 1 NC_007384.1 Code: C; COG: COG0650; hydrogenase 4 membrane subunit 2706847 hyfC 3667793 hyfC Shigella sonnei Ss046 hydrogenase 4 membrane subunit YP_311428.1 2705879 D 300269 CDS YP_311429.1 74313010 3667794 2706986..2708302 1 NC_007384.1 Code: CP; COG: COG1009; hydrogenase 4 subunit D 2708302 hyfD 3667794 hyfD Shigella sonnei Ss046 hydrogenase 4 subunit D YP_311429.1 2706986 D 300269 CDS YP_311430.1 74313011 3667795 2708314..2708964 1 NC_007384.1 interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 2708964 hyfE 3667795 hyfE Shigella sonnei Ss046 hydrogenase 4 membrane subunit YP_311430.1 2708314 D 300269 CDS YP_311431.1 74313012 3667796 2708969..2710549 1 NC_007384.1 Code: CP; COG: COG0651; hydrogenase 4 subunit F 2710549 hyfF 3667796 hyfF Shigella sonnei Ss046 hydrogenase 4 subunit F YP_311431.1 2708969 D 300269 CDS YP_311432.1 74313013 3667797 2710539..2712254 1 NC_007384.1 Code: C; COG: COG3261; hydrogenase 4 subunit 2712254 hyfG 3667797 hyfG Shigella sonnei Ss046 hydrogenase 4 subunit YP_311432.1 2710539 D 300269 CDS YP_311433.1 74313014 3667798 2712264..2712803 1 NC_007384.1 probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far; hydrogenase 4 subunit H 2712803 hyfH 3667798 hyfH Shigella sonnei Ss046 hydrogenase 4 subunit H YP_311433.1 2712264 D 300269 CDS YP_311434.1 74313015 3667799 2712800..2713558 1 NC_007384.1 Code: C; COG: COG3260; hydrogenase 4 Fe-S subunit 2713558 hyfI 3667799 hyfI Shigella sonnei Ss046 hydrogenase 4 Fe-S subunit YP_311434.1 2712800 D 300269 CDS YP_311435.1 74313016 3667800 2713488..2713964 1 NC_007384.1 protein processing element 2713964 3667800 SSON_2571 Shigella sonnei Ss046 protein processing element YP_311435.1 2713488 D 300269 CDS YP_311436.1 74313017 3667801 2714015..2716006 1 NC_007384.1 Code: KT; COG: COG3604; 2-component regulator 2716006 hyfR 3667801 hyfR Shigella sonnei Ss046 2-component regulator YP_311436.1 2714015 D 300269 CDS YP_311437.1 74313018 3667803 2716935..2718131 1 NC_007384.1 Code: L; COG: COG3547; ISSfl2 ORF 2718131 3667803 SSON_2574 Shigella sonnei Ss046 ISSfl2 ORF YP_311437.1 2716935 D 300269 CDS YP_311438.1 74313019 3667804 complement(2718362..2719423) 1 NC_007384.1 Code: R; COG: COG0628; permease 2719423 perM 3667804 perM Shigella sonnei Ss046 permease YP_311438.1 2718362 R 300269 CDS YP_311439.1 74313020 3667805 2719636..2721099 1 NC_007384.1 Code: R; COG: COG4783; hypothetical protein 2721099 3667805 SSON_2576 Shigella sonnei Ss046 hypothetical protein YP_311439.1 2719636 D 300269 CDS YP_311440.1 74313021 3667806 2721120..2721479 1 NC_007384.1 Code: P; COG: COG1393; oxidoreductase 2721479 3667806 SSON_2577 Shigella sonnei Ss046 oxidoreductase YP_311440.1 2721120 D 300269 CDS YP_311441.1 74313022 3667807 complement(2721617..2722363) 1 NC_007384.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor 2722363 3667807 SSON_2578 Shigella sonnei Ss046 DNA replication initiation factor YP_311441.1 2721617 R 300269 CDS YP_311442.1 74313023 3668034 complement(2722413..2723702) 1 NC_007384.1 Code: F; COG: COG2233; uracil transporter 2723702 uraA 3668034 uraA Shigella sonnei Ss046 uracil transporter YP_311442.1 2722413 R 300269 CDS YP_311443.2 161986481 3668035 complement(2723788..2724414) 1 NC_007384.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 2724414 upp 3668035 upp Shigella sonnei Ss046 uracil phosphoribosyltransferase YP_311443.2 2723788 R 300269 CDS YP_311444.1 74313025 3668036 2724739..2725776 1 NC_007384.1 AIR synthetase; catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2725776 purM 3668036 purM Shigella sonnei Ss046 phosphoribosylaminoimidazole synthetase YP_311444.1 2724739 D 300269 CDS YP_311445.1 74313026 3668037 2725776..2726414 1 NC_007384.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 2726414 purN 3668037 purN Shigella sonnei Ss046 phosphoribosylglycinamide formyltransferase YP_311445.1 2725776 D 300269 CDS YP_311446.1 74313027 3668038 2726585..2728651 1 NC_007384.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2728651 ppk 3668038 ppk Shigella sonnei Ss046 polyphosphate kinase YP_311446.1 2726585 D 300269 CDS YP_311447.1 74313028 3668039 2728656..2730197 1 NC_007384.1 Code: FP; COG: COG0248; exopolyphosphatase 2730197 ppx 3668039 ppx Shigella sonnei Ss046 exopolyphosphatase YP_311447.1 2728656 D 300269 CDS YP_311448.1 74313029 3668040 complement(2730236..2732479) 1 NC_007384.1 Code: T; COG: COG2200; cytochrome C-type biogenesis protein 2732479 3668040 SSON_2585 Shigella sonnei Ss046 cytochrome C-type biogenesis protein YP_311448.1 2730236 R 300269 CDS YP_311449.1 74313030 3668041 2732831..2733022 1 NC_007384.1 hypothetical protein 2733022 3668041 SSON_2586 Shigella sonnei Ss046 hypothetical protein YP_311449.1 2732831 D 300269 CDS YP_311450.1 74313031 3668042 2733333..2733851 1 NC_007384.1 outer membrane lipoprotein 2733851 3668042 SSON_2587 Shigella sonnei Ss046 outer membrane lipoprotein YP_311450.1 2733333 D 300269 CDS YP_311451.1 74313032 3668043 2733867..2734406 1 NC_007384.1 hypothetical protein 2734406 3668043 SSON_2588 Shigella sonnei Ss046 hypothetical protein YP_311451.1 2733867 D 300269 CDS YP_311452.1 74313033 3668044 complement(2734501..2736078) 1 NC_007384.1 glutamine-hydrolyzing; contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 2736078 guaA 3668044 guaA Shigella sonnei Ss046 GMP synthase YP_311452.1 2734501 R 300269 CDS YP_311453.1 74313034 3668045 complement(2736147..2737613) 1 NC_007384.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 2737613 guaB 3668045 guaB Shigella sonnei Ss046 inosine 5'-monophosphate dehydrogenase YP_311453.1 2736147 R 300269 CDS YP_311454.1 74313035 3668046 2737775..2739145 1 NC_007384.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2739145 xseA 3668046 xseA Shigella sonnei Ss046 exodeoxyribonuclease VII large subunit YP_311454.1 2737775 D 300269 CDS YP_311455.1 74313036 3668047 complement(2739142..2739378) 1 NC_007384.1 hypothetical protein 2739378 3668047 SSON_2592 Shigella sonnei Ss046 hypothetical protein YP_311455.1 2739142 R 300269 CDS YP_311456.2 161986480 3668048 complement(2739426..2740898) 1 NC_007384.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 2740898 engA 3668048 engA Shigella sonnei Ss046 GTP-binding protein EngA YP_311456.2 2739426 R 300269 CDS YP_311457.1 74313038 3668049 complement(2741016..2742194) 1 NC_007384.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL 2742194 3668049 SSON_2594 Shigella sonnei Ss046 outer membrane protein assembly complex subunit YfgL YP_311457.1 2741016 R 300269 CDS YP_311458.1 74313039 3668050 complement(2742205..2742825) 1 NC_007384.1 Code: S; COG: COG2976; hypothetical protein 2742825 3668050 SSON_2595 Shigella sonnei Ss046 hypothetical protein YP_311458.1 2742205 R 300269 CDS YP_311459.1 74313040 3668051 complement(2742843..2744117) 1 NC_007384.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 2744117 hisS 3668051 hisS Shigella sonnei Ss046 histidyl-tRNA synthetase YP_311459.1 2742843 R 300269 CDS YP_311460.1 74313041 3668052 complement(2744228..2745346) 1 NC_007384.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2745346 ispG 3668052 ispG Shigella sonnei Ss046 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_311460.1 2744228 R 300269 CDS YP_311461.1 74313042 3668106 complement(2745373..2746386) 1 NC_007384.1 Code: S; COG: COG1426; cytoskeletal protein RodZ 2746386 yfgA 3668106 yfgA Shigella sonnei Ss046 cytoskeletal protein RodZ YP_311461.1 2745373 R 300269 CDS YP_311462.1 74313043 3668107 complement(2746671..2747825) 1 NC_007384.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 2747825 yfgB 3668107 yfgB Shigella sonnei Ss046 ribosomal RNA large subunit methyltransferase N YP_311462.1 2746671 R 300269 CDS YP_311463.1 74313044 3668108 complement(2747975..2748406) 1 NC_007384.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 2748406 ndk 3668108 ndk Shigella sonnei Ss046 nucleoside diphosphate kinase YP_311463.1 2747975 R 300269 CDS YP_311464.1 74313045 3668109 complement(2748555..2750867) 1 NC_007384.1 penicillin-insensitive transglycosylase/transpeptidase; penicillin-binding protein 1C 2750867 pbpC 3668109 pbpC Shigella sonnei Ss046 penicillin-binding protein 1C YP_311464.1 2748555 R 300269 CDS YP_311465.1 74313046 3668110 complement(2750868..2755829) 1 NC_007384.1 Code: R; COG: COG2373; hypothetical protein 2755829 3668110 SSON_2602 Shigella sonnei Ss046 hypothetical protein YP_311465.1 2750868 R 300269 CDS YP_311466.2 161986479 3668111 2756036..2756881 1 NC_007384.1 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 2756881 sseA 3668111 sseA Shigella sonnei Ss046 3-mercaptopyruvate sulfurtransferase YP_311466.2 2756036 D 300269 CDS YP_311467.2 161986478 3668112 complement(2757374..2758150) 1 NC_007384.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB 2758150 sseB 3668112 sseB Shigella sonnei Ss046 enhanced serine sensitivity protein SseB YP_311467.2 2757374 R 300269 CDS YP_311468.2 161986477 3668113 complement(2758292..2759575) 1 NC_007384.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase 2759575 pepB 3668113 pepB Shigella sonnei Ss046 aminopeptidase YP_311468.2 2758292 R 300269 CDS YP_311469.1 74313050 3668114 complement(2759753..2759953) 1 NC_007384.1 Code: S; COG: COG2975; hypothetical protein 2759953 yfhJ 3668114 yfhJ Shigella sonnei Ss046 hypothetical protein YP_311469.1 2759753 R 300269 CDS YP_311470.1 74313051 3668115 complement(2759965..2760300) 1 NC_007384.1 Code: C; COG: COG0633; [2FE-2S] ferredoxin, electron carrer protein 2760300 fdx 3668115 fdx Shigella sonnei Ss046 [2FE-2S] ferredoxin, electron carrer protein YP_311470.1 2759965 R 300269 CDS YP_311471.1 74313052 3668116 complement(2760302..2762152) 1 NC_007384.1 chaperone; member of Hsp70 protein family; involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 2762152 hscA 3668116 hscA Shigella sonnei Ss046 chaperone protein HscA YP_311471.1 2760302 R 300269 CDS YP_311472.1 74313053 3668117 complement(2762169..2762684) 1 NC_007384.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB 2762684 hscB 3668117 hscB Shigella sonnei Ss046 co-chaperone HscB YP_311472.1 2762169 R 300269 CDS YP_311473.1 74313054 3668118 complement(2762780..2763103) 1 NC_007384.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein 2763103 iscA 3668118 iscA Shigella sonnei Ss046 iron-sulfur cluster assembly protein YP_311473.1 2762780 R 300269 CDS YP_311474.1 74313055 3668119 complement(2763120..2763506) 1 NC_007384.1 Code: C; COG: COG0822; scaffold protein 2763506 3668119 SSON_2611 Shigella sonnei Ss046 scaffold protein YP_311474.1 2763120 R 300269 CDS YP_311475.1 74313056 3668120 complement(2763534..2764772) 1 NC_007384.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 2764772 yfhO 3668120 yfhO Shigella sonnei Ss046 cysteine desulfurase YP_311475.1 2763534 R 300269 CDS YP_311476.1 74313057 3668121 complement(2764989..2765477) 1 NC_007384.1 regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR 2765477 3668121 SSON_2613 Shigella sonnei Ss046 DNA-binding transcriptional regulator IscR YP_311476.1 2764989 R 300269 CDS YP_311477.1 74313058 3668122 complement(2765778..2766515) 1 NC_007384.1 Code: J; COG: COG0565; ATP synthase subunit beta 2766515 3668122 SSON_2614 Shigella sonnei Ss046 ATP synthase subunit beta YP_311477.1 2765778 R 300269 CDS YP_311478.1 74313059 3668123 2766634..2767437 1 NC_007384.1 enhances synthesis of sigma32 in mutant; extragenic suppressor, may modulate RNAse III lethal action; Code: G; COG: COG0483; inositol monophosphatase 2767437 suhB 3668123 suhB Shigella sonnei Ss046 inositol monophosphatase YP_311478.1 2766634 D 300269 CDS YP_311479.1 74313060 3668124 2767555..2768436 1 NC_007384.1 Code: R; COG: COG1073; hypothetical protein 2768436 3668124 SSON_2616 Shigella sonnei Ss046 hypothetical protein YP_311479.1 2767555 D 300269 CDS YP_311480.2 161986476 3668125 2768627..2769907 1 NC_007384.1 Code: K; COG: COG3711; stationary phase inducible protein CsiE 2769907 csiE 3668125 csiE Shigella sonnei Ss046 stationary phase inducible protein CsiE YP_311480.2 2768627 D 300269 CDS YP_311481.1 74313062 3668238 complement(2769899..2771038) 1 NC_007384.1 transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; 3-phenylpropionic acid transporter 2771038 hcaT 3668238 hcaT Shigella sonnei Ss046 3-phenylpropionic acid transporter YP_311481.1 2769899 R 300269 CDS YP_311482.1 74313063 3668240 2772224..2773585 1 NC_007384.1 Code: PR; COG: COG4638; large terminal subunit of phenylpropionate dioxygenase 2773585 hcaA1 3668240 hcaA1 Shigella sonnei Ss046 large terminal subunit of phenylpropionate dioxygenase YP_311482.1 2772224 D 300269 CDS YP_311483.1 74313064 3668241 2773582..2774100 1 NC_007384.1 Code: Q; COG: COG5517; 3-phenylpropionate dioxygenase subunit beta 2774100 hcaA2 3668241 hcaA2 Shigella sonnei Ss046 3-phenylpropionate dioxygenase subunit beta YP_311483.1 2773582 D 300269 CDS YP_311484.1 74313065 3668242 2774100..2774420 1 NC_007384.1 Code: PR; COG: COG2146; 3-phenylpropionate dioxygenase ferredoxin subunit 2774420 hcaC 3668242 hcaC Shigella sonnei Ss046 3-phenylpropionate dioxygenase ferredoxin subunit YP_311484.1 2774100 D 300269 CDS YP_311485.1 74313066 3668243 2774417..2775229 1 NC_007384.1 Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 2775229 hcaB 3668243 hcaB Shigella sonnei Ss046 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase YP_311485.1 2774417 D 300269 CDS YP_311486.1 74313067 3668244 2775239..2776441 1 NC_007384.1 Code: R; COG: COG0446; phenylpropionate dioxygenase ferredoxin reductase subunit 2776441 hcaD 3668244 hcaD Shigella sonnei Ss046 phenylpropionate dioxygenase ferredoxin reductase subunit YP_311486.1 2775239 D 300269 CDS YP_311487.1 74313068 3668245 2776812..2777315 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2777315 3668245 SSON_2625 Shigella sonnei Ss046 IS1 ORF YP_311487.1 2776812 D 300269 CDS YP_311488.1 74313069 3668247 complement(2777794..2778666) 1 NC_007384.1 Code: G; COG: COG2017; hypothetical protein 2778666 yphB 3668247 yphB Shigella sonnei Ss046 hypothetical protein YP_311488.1 2777794 R 300269 CDS YP_311489.1 74313070 3668248 complement(2778678..2779772) 1 NC_007384.1 Code: ER; COG: COG1063; oxidoreductase 2779772 yphC 3668248 yphC Shigella sonnei Ss046 oxidoreductase YP_311489.1 2778678 R 300269 CDS YP_311490.1 74313071 3668249 complement(2779805..2780803) 1 NC_007384.1 Code: G; COG: COG1172; transport system permease 2780803 yphD 3668249 yphD Shigella sonnei Ss046 transport system permease YP_311490.1 2779805 R 300269 CDS YP_311491.1 74313072 3668250 complement(2780828..2782339) 1 NC_007384.1 Code: G; COG: COG1129; ABC transporter ATP-binding protein 2782339 yphE 3668250 yphE Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_311491.1 2780828 R 300269 CDS YP_311492.1 74313073 3668251 complement(2782362..2783345) 1 NC_007384.1 Code: G; COG: COG1879; LACI-type transcriptional regulator 2783345 yphF 3668251 yphF Shigella sonnei Ss046 LACI-type transcriptional regulator YP_311492.1 2782362 R 300269 CDS YP_311493.1 74313074 3668254 complement(2788228..2789481) 1 NC_007384.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 2789481 glyA 3668254 glyA Shigella sonnei Ss046 serine hydroxymethyltransferase YP_311493.1 2788228 R 300269 CDS YP_311494.1 74313075 3668255 2789809..2790999 1 NC_007384.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 2790999 hmpA 3668255 hmpA Shigella sonnei Ss046 nitric oxide dioxygenase YP_311494.1 2789809 D 300269 CDS YP_311495.1 74313076 3668256 complement(2791044..2791382) 1 NC_007384.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 2791382 glnB 3668256 glnB Shigella sonnei Ss046 nitrogen regulatory protein P-II 1 YP_311495.1 2791044 R 300269 CDS YP_311496.1 74313077 3668431 complement(2791443..2792777) 1 NC_007384.1 Code: T; COG: COG2204; 2-component transcriptional regulator 2792777 yfhA 3668431 yfhA Shigella sonnei Ss046 2-component transcriptional regulator YP_311496.1 2791443 R 300269 CDS YP_311497.1 74313078 3668432 complement(2792767..2793480) 1 NC_007384.1 hypothetical protein 2793480 yfhG 3668432 yfhG Shigella sonnei Ss046 hypothetical protein YP_311497.1 2792767 R 300269 CDS YP_311498.1 74313079 3668433 complement(2793645..2795135) 1 NC_007384.1 Code: T; COG: COG0642; 2-component sensor protein 2795135 yfhK 3668433 yfhK Shigella sonnei Ss046 2-component sensor protein YP_311498.1 2793645 R 300269 CDS YP_311499.1 74313080 3668434 complement(2795630..2799517) 1 NC_007384.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 2799517 purL 3668434 purL Shigella sonnei Ss046 phosphoribosylformylglycinamidine synthase YP_311499.1 2795630 R 300269 CDS YP_311500.1 74313081 3668435 2799913..2801331 1 NC_007384.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; transglycosylase 2801331 yfhD 3668435 yfhD Shigella sonnei Ss046 transglycosylase YP_311500.1 2799913 D 300269 CDS YP_311501.1 74313082 3668436 complement(2801328..2801864) 1 NC_007384.1 Code: FJ; COG: COG0590; tRNA-specific adenosine deaminase 2801864 yfhC 3668436 yfhC Shigella sonnei Ss046 tRNA-specific adenosine deaminase YP_311501.1 2801328 R 300269 CDS YP_311502.2 161986475 3668437 complement(2801889..2802524) 1 NC_007384.1 Code: E; COG: COG0560; hypothetical protein 2802524 yfhB 3668437 yfhB Shigella sonnei Ss046 hypothetical protein YP_311502.2 2801889 R 300269 CDS YP_311503.2 161986474 3668438 2802733..2803581 1 NC_007384.1 Code: K; COG: COG1737; DNA-binding transcriptional regulator 2803581 yfhH 3668438 yfhH Shigella sonnei Ss046 DNA-binding transcriptional regulator YP_311503.2 2802733 D 300269 CDS YP_311504.1 74313085 3668440 2804968..2806794 1 NC_007384.1 Code: S; COG: COG4886; invasion plasmid antigen 2806794 ipaH_5 3668440 ipaH_5 Shigella sonnei Ss046 invasion plasmid antigen YP_311504.1 2804968 D 300269 CDS YP_311505.1 74313086 3668441 complement(2806974..2807597) 1 NC_007384.1 hypothetical protein 2807597 3668441 SSON_2647 Shigella sonnei Ss046 hypothetical protein YP_311505.1 2806974 R 300269 CDS YP_311506.1 74313087 3668442 complement(2807548..2808714) 1 NC_007384.1 tail fiber protein 2808714 3668442 SSON_2648 Shigella sonnei Ss046 tail fiber protein YP_311506.1 2807548 R 300269 CDS YP_311507.1 74313088 3668443 complement(2808774..2809232) 1 NC_007384.1 protein encoded within IS 2809232 3668443 SSON_2649 Shigella sonnei Ss046 protein encoded within IS YP_311507.1 2808774 R 300269 CDS YP_311508.1 74313089 3668444 complement(2809282..2809629) 1 NC_007384.1 Code: L; COG: COG3436; protein encoded within IS 2809629 3668444 SSON_2650 Shigella sonnei Ss046 protein encoded within IS YP_311508.1 2809282 R 300269 CDS YP_311509.1 74313090 3668445 complement(2809868..2810581) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 2810581 3668445 SSON_2651 Shigella sonnei Ss046 IS600 ORF2 YP_311509.1 2809868 R 300269 CDS YP_311510.1 74313091 3668446 complement(2810722..2811024) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 2811024 3668446 SSON_2652 Shigella sonnei Ss046 IS600 ORF1 YP_311510.1 2810722 R 300269 CDS YP_311511.1 74313092 3668447 complement(2811621..2812748) 1 NC_007384.1 Code: L; COG: COG3547; transposase 2812748 3668447 SSON_2653 Shigella sonnei Ss046 transposase YP_311511.1 2811621 R 300269 CDS YP_311512.1 74313093 3668448 complement(2813123..2813770) 1 NC_007384.1 Code: L; COG: COG2801; IS629 ORF2 2813770 3668448 SSON_2654 Shigella sonnei Ss046 IS629 ORF2 YP_311512.1 2813123 R 300269 CDS YP_311513.1 74313094 3668449 complement(2813990..2814331) 1 NC_007384.1 Code: L; COG: COG2963; IS629 ORF1 2814331 3668449 SSON_2655 Shigella sonnei Ss046 IS629 ORF1 YP_311513.1 2813990 R 300269 CDS YP_311514.1 74313095 3668450 2814429..2814689 1 NC_007384.1 hypothetical protein 2814689 yfdA 3668450 yfdA Shigella sonnei Ss046 hypothetical protein YP_311514.1 2814429 D 300269 CDS YP_311515.1 74313096 3668257 2814686..2815276 1 NC_007384.1 hypothetical protein 2815276 3668257 SSON_2657 Shigella sonnei Ss046 hypothetical protein YP_311515.1 2814686 D 300269 CDS YP_311516.1 74313097 3668258 complement(2815296..2815643) 1 NC_007384.1 hypothetical protein 2815643 3668258 SSON_2658 Shigella sonnei Ss046 hypothetical protein YP_311516.1 2815296 R 300269 CDS YP_311517.1 74313098 3668259 2815829..2816107 1 NC_007384.1 immunity protein for colicin IA 2816107 3668259 SSON_2659 Shigella sonnei Ss046 immunity protein for colicin IA YP_311517.1 2815829 D 300269 CDS YP_311518.2 161986473 3668260 2817646..2818551 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2818551 3668260 SSON_2660 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_311518.2 2817646 D 300269 CDS YP_311519.1 74313100 3668261 2819082..2819648 1 NC_007384.1 Rep protein 2819648 3668261 SSON_2661 Shigella sonnei Ss046 Rep protein YP_311519.1 2819082 D 300269 CDS YP_311520.1 74313101 3668262 2819939..2820856 1 NC_007384.1 Code: S; COG: COG3016; iron-regulated protein 2820856 cjrA 3668262 cjrA Shigella sonnei Ss046 iron-regulated protein YP_311520.1 2819939 D 300269 CDS YP_311521.1 74313102 3668263 2821089..2821640 1 NC_007384.1 TonB-like; Code: M; COG: COG0810; colicin Js-sensitive membrane protein 2821640 cjrB 3668263 cjrB Shigella sonnei Ss046 colicin Js-sensitive membrane protein YP_311521.1 2821089 D 300269 CDS YP_311522.1 74313103 3668264 2821809..2824070 1 NC_007384.1 Code: P; COG: COG1629; colicin Js-sensitive receptor protein 2824070 cjrC 3668264 cjrC Shigella sonnei Ss046 colicin Js-sensitive receptor protein YP_311522.1 2821809 D 300269 CDS YP_311523.1 74313104 3668265 2824139..2825314 1 NC_007384.1 enterotoxin 2825314 senB 3668265 senB Shigella sonnei Ss046 enterotoxin YP_311523.1 2824139 D 300269 CDS YP_311524.1 74313105 3668266 complement(2826339..2827730) 1 NC_007384.1 Code: L; COG: COG3436; protein encoded within IS 2827730 3668266 SSON_2666 Shigella sonnei Ss046 protein encoded within IS YP_311524.1 2826339 R 300269 CDS YP_311525.1 74313106 3668267 complement(2827927..2828274) 1 NC_007384.1 Code: L; COG: COG3436; protein encoded within IS 2828274 3668267 SSON_2667 Shigella sonnei Ss046 protein encoded within IS YP_311525.1 2827927 R 300269 CDS YP_311526.1 74313107 3668268 2828986..2829489 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2829489 3668268 SSON_2668 Shigella sonnei Ss046 IS1 ORF YP_311526.1 2828986 D 300269 CDS YP_311527.1 74313108 3668269 complement(2829779..2830954) 1 NC_007384.1 Code: L; COG: COG3547; transposase 2830954 3668269 SSON_2669 Shigella sonnei Ss046 transposase YP_311527.1 2829779 R 300269 CDS YP_311528.1 74313109 3668270 2831037..2831339 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 2831339 3668270 SSON_2670 Shigella sonnei Ss046 IS600 ORF1 YP_311528.1 2831037 D 300269 CDS YP_311529.1 74313110 3668271 2831480..2832193 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 2832193 3668271 SSON_2671 Shigella sonnei Ss046 IS600 ORF2 YP_311529.1 2831480 D 300269 CDS YP_311530.1 74313111 3668272 complement(2832902..2833462) 1 NC_007384.1 conjugal transfer fertility inhibition protein FinO 2833462 finO 3668272 finO Shigella sonnei Ss046 conjugal transfer fertility inhibition protein FinO YP_311530.1 2832902 R 300269 CDS YP_311531.1 74313112 3668274 complement(2834284..2835486) 1 NC_007384.1 hypothetical protein 2835486 3668274 SSON_2674 Shigella sonnei Ss046 hypothetical protein YP_311531.1 2834284 R 300269 CDS YP_311532.1 74313113 3668275 complement(2835585..2835971) 1 NC_007384.1 conjugal transfer protein TrbI 2835971 trbI 3668275 trbI Shigella sonnei Ss046 conjugal transfer protein TrbI YP_311532.1 2835585 R 300269 CDS YP_311533.1 74313114 3669241 complement(2835968..2837239) 1 NC_007384.1 Code: U; COG: COG3451; hypothetical protein 2837239 3669241 SSON_2676 Shigella sonnei Ss046 hypothetical protein YP_311533.1 2835968 R 300269 CDS YP_311534.1 74313115 3669242 complement(2837424..2837735) 1 NC_007384.1 conjugal transfer pilus assembly protein TraL 2837735 traL 3669242 traL Shigella sonnei Ss046 conjugal transfer pilus assembly protein TraL YP_311534.1 2837424 R 300269 CDS YP_311535.1 74313116 3669243 complement(2837750..2838031) 1 NC_007384.1 conjugal transfer protein TraA 2838031 traA 3669243 traA Shigella sonnei Ss046 conjugal transfer protein TraA YP_311535.1 2837750 R 300269 CDS YP_311536.1 74313117 3669244 complement(2838146..2839033) 1 NC_007384.1 Code: L; COG: COG2801; IS629 ORF2 2839033 3669244 SSON_2679 Shigella sonnei Ss046 IS629 ORF2 YP_311536.1 2838146 R 300269 CDS YP_311537.1 74313118 3669245 complement(2839033..2839359) 1 NC_007384.1 Code: L; COG: COG2963; IS629 ORF1 2839359 3669245 SSON_2680 Shigella sonnei Ss046 IS629 ORF1 YP_311537.1 2839033 R 300269 CDS YP_311538.1 74313119 3669246 complement(2839740..2840537) 1 NC_007384.1 Code: L; COG: COG1484; IS21 ORF2 2840537 3669246 SSON_2681 Shigella sonnei Ss046 IS21 ORF2 YP_311538.1 2839740 R 300269 CDS YP_311539.1 74313120 3669247 complement(2840537..2841709) 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 2841709 3669247 SSON_2682 Shigella sonnei Ss046 IS21 ORF1 YP_311539.1 2840537 R 300269 CDS YP_311540.1 74313121 3669248 2841854..2842150 1 NC_007384.1 protein encoded within IS 2842150 3669248 SSON_2683 Shigella sonnei Ss046 protein encoded within IS YP_311540.1 2841854 D 300269 CDS YP_311541.1 74313122 3669249 2842150..2843337 1 NC_007384.1 IS91 orf 2843337 3669249 SSON_2684 Shigella sonnei Ss046 IS91 orf YP_311541.1 2842150 D 300269 CDS YP_311542.1 74313123 3669250 complement(2843510..2844712) 1 NC_007384.1 hypothetical protein 2844712 3669250 SSON_2685 Shigella sonnei Ss046 hypothetical protein YP_311542.1 2843510 R 300269 CDS YP_311543.1 74313124 3669251 2844927..2845187 1 NC_007384.1 Code: C; COG: COG1145; hypothetical protein 2845187 yfhL 3669251 yfhL Shigella sonnei Ss046 hypothetical protein YP_311543.1 2844927 D 300269 CDS YP_311544.1 74313125 3669252 complement(2845683..2846063) 1 NC_007384.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 2846063 acpS 3669252 acpS Shigella sonnei Ss046 4'-phosphopantetheinyl transferase YP_311544.1 2845683 R 300269 CDS YP_311545.1 74313126 3669253 complement(2846063..2846794) 1 NC_007384.1 involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase 2846794 pdxJ 3669253 pdxJ Shigella sonnei Ss046 pyridoxine 5'-phosphate synthase YP_311545.1 2846063 R 300269 CDS YP_311546.1 74313127 3669254 complement(2846806..2847534) 1 NC_007384.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 2847534 recO 3669254 recO Shigella sonnei Ss046 DNA repair protein RecO YP_311546.1 2846806 R 300269 CDS YP_311547.1 74313128 3669255 complement(2847546..2848451) 1 NC_007384.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 2848451 era 3669255 era Shigella sonnei Ss046 GTP-binding protein Era YP_311547.1 2847546 R 300269 CDS YP_311548.1 74313129 3669256 complement(2848448..2849128) 1 NC_007384.1 ds RNA; cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 2849128 rnc 3669256 rnc Shigella sonnei Ss046 ribonuclease III YP_311548.1 2848448 R 300269 CDS YP_311549.1 74313130 3669257 complement(2849401..2850375) 1 NC_007384.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I 2850375 lepB 3669257 lepB Shigella sonnei Ss046 signal peptidase I YP_311549.1 2849401 R 300269 CDS YP_311550.1 74313131 3669258 complement(2850391..2852190) 1 NC_007384.1 may be inner membrane protein; binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 2852190 lepA 3669258 lepA Shigella sonnei Ss046 GTP-binding protein LepA YP_311550.1 2850391 R 300269 CDS YP_311551.1 74313132 3669259 complement(2852388..2852867) 1 NC_007384.1 negative regulatory protein; involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC 2852867 rseC 3669259 rseC Shigella sonnei Ss046 SoxR reducing system protein RseC YP_311551.1 2852388 R 300269 CDS YP_311552.1 74313133 3669260 complement(2852864..2853820) 1 NC_007384.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE 2853820 rseB 3669260 rseB Shigella sonnei Ss046 periplasmic negative regulator of sigmaE YP_311552.1 2852864 R 300269 CDS YP_311553.1 74313134 3666856 complement(2853820..2854470) 1 NC_007384.1 Code: T; COG: COG3073; anti-RNA polymerase sigma factor SigE 2854470 rseA 3666856 rseA Shigella sonnei Ss046 anti-RNA polymerase sigma factor SigE YP_311553.1 2853820 R 300269 CDS YP_311554.1 74313135 3666857 complement(2854503..2855078) 1 NC_007384.1 heat shock and oxidative stress; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 2855078 rpoE 3666857 rpoE Shigella sonnei Ss046 RNA polymerase sigma factor RpoE YP_311554.1 2854503 R 300269 CDS YP_311555.1 74313136 3666859 2856250..2856552 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 2856552 3666859 SSON_2699 Shigella sonnei Ss046 IS600 ORF1 YP_311555.1 2856250 D 300269 CDS YP_311556.1 74313137 3666860 2856693..2857406 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 2857406 3666860 SSON_2700 Shigella sonnei Ss046 IS600 ORF2 YP_311556.1 2856693 D 300269 CDS YP_311557.1 74313138 3666861 complement(2858360..2859217) 1 NC_007384.1 Code: R; COG: COG4123; hypothetical protein 2859217 yfiC 3666861 yfiC Shigella sonnei Ss046 hypothetical protein YP_311557.1 2858360 R 300269 CDS YP_311558.1 74313139 3666862 2859229..2860563 1 NC_007384.1 facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2860563 srmB 3666862 srmB Shigella sonnei Ss046 ATP-dependent RNA helicase SrmB YP_311558.1 2859229 D 300269 CDS YP_311559.1 74313140 3666863 complement(2860772..2861698) 1 NC_007384.1 Code: K; COG: COG0583; LysR family transcriptional regulator 2861698 yfiE 3666863 yfiE Shigella sonnei Ss046 LysR family transcriptional regulator YP_311559.1 2860772 R 300269 CDS YP_311560.1 74313141 3666864 2861756..2862343 1 NC_007384.1 Code: E; COG: COG1280; neutral amino-acid efflux protein 2862343 yfiK 3666864 yfiK Shigella sonnei Ss046 neutral amino-acid efflux protein YP_311560.1 2861756 D 300269 CDS YP_311561.1 74313142 3666865 complement(2862399..2862782) 1 NC_007384.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA 2862782 yfiD 3666865 yfiD Shigella sonnei Ss046 autonomous glycyl radical cofactor GrcA YP_311561.1 2862399 R 300269 CDS YP_311562.1 74313143 3666866 2863087..2863776 1 NC_007384.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2863776 ung 3666866 ung Shigella sonnei Ss046 uracil-DNA glycosylase YP_311562.1 2863087 D 300269 CDS YP_311563.1 74313144 3666867 complement(2863824..2864861) 1 NC_007384.1 Code: J; COG: COG0566; methyltransferase 2864861 yfiF 3666867 yfiF Shigella sonnei Ss046 methyltransferase YP_311563.1 2863824 R 300269 CDS YP_311564.1 74313145 3666868 2865068..2865487 1 NC_007384.1 Code: OC; COG: COG0526; thioredoxin 2865487 trxC 3666868 trxC Shigella sonnei Ss046 thioredoxin YP_311564.1 2865068 D 300269 CDS YP_311565.1 74313146 3666869 2865532..2866254 1 NC_007384.1 Code: S; COG: COG3148; hypothetical protein 2866254 yfiP 3666869 yfiP Shigella sonnei Ss046 hypothetical protein YP_311565.1 2865532 D 300269 CDS YP_311566.1 74313147 3666870 2866286..2868946 1 NC_007384.1 Code: C; COG: COG1042; hypothetical protein 2868946 yfiQ 3666870 yfiQ Shigella sonnei Ss046 hypothetical protein YP_311566.1 2866286 D 300269 CDS YP_311567.1 74313148 3666871 2869057..2870415 1 NC_007384.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 2870415 pssA 3666871 pssA Shigella sonnei Ss046 phosphatidylserine synthase YP_311567.1 2869057 D 300269 CDS YP_311568.1 74313149 3666872 2870512..2870784 1 NC_007384.1 Code: R; COG: COG5544; hypothetical protein 2870784 yfiM 3666872 yfiM Shigella sonnei Ss046 hypothetical protein YP_311568.1 2870512 D 300269 CDS YP_311569.1 74313150 3666873 complement(2870781..2872079) 1 NC_007384.1 Code: GEPR; COG: COG0477; alpha-ketoglutarate transporter 2872079 kgtP 3666873 kgtP Shigella sonnei Ss046 alpha-ketoglutarate transporter YP_311569.1 2870781 R 300269 CDS YP_311570.1 74313151 3666658 complement(2877856..2880429) 1 NC_007384.1 Code: O; COG: COG0542; protein disaggregation chaperone 2880429 clpB 3666658 clpB Shigella sonnei Ss046 protein disaggregation chaperone YP_311570.1 2877856 R 300269 CDS YP_311571.1 74313152 3666659 complement(2880559..2881290) 1 NC_007384.1 Code: S; COG: COG1496; hypothetical protein 2881290 yfiH 3666659 yfiH Shigella sonnei Ss046 hypothetical protein YP_311571.1 2880559 R 300269 CDS YP_311572.1 74313153 3666660 complement(2881287..2882267) 1 NC_007384.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D 2882267 rluD 3666660 rluD Shigella sonnei Ss046 23S rRNA pseudouridine synthase D YP_311572.1 2881287 R 300269 CDS YP_311573.1 74313154 3666661 2882402..2883139 1 NC_007384.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 2883139 3666661 SSON_2721 Shigella sonnei Ss046 outer membrane protein assembly complex subunit YfiO YP_311573.1 2882402 D 300269 CDS YP_311574.1 74313155 3666662 2883243..2884589 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 2884589 3666662 SSON_2722 Shigella sonnei Ss046 IS4 orf YP_311574.1 2883243 D 300269 CDS YP_311575.1 74313156 3666663 2884693..2885055 1 NC_007384.1 Code: R; COG: COG3740; prohead protease 2885055 3666663 SSON_2723 Shigella sonnei Ss046 prohead protease YP_311575.1 2884693 D 300269 CDS YP_311576.1 74313157 3666664 2885117..2885419 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 2885419 3666664 SSON_2724 Shigella sonnei Ss046 IS600 ORF1 YP_311576.1 2885117 D 300269 CDS YP_311577.1 74313158 3666665 2885560..2886273 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 2886273 3666665 SSON_2725 Shigella sonnei Ss046 IS600 ORF2 YP_311577.1 2885560 D 300269 CDS YP_311578.1 74313159 3666666 2886336..2887832 1 NC_007384.1 Code: R; COG: COG4386; sheath protein 2887832 3666666 SSON_2726 Shigella sonnei Ss046 sheath protein YP_311578.1 2886336 D 300269 CDS YP_311579.1 74313160 3666667 2887832..2888188 1 NC_007384.1 hypothetical protein 2888188 3666667 SSON_2727 Shigella sonnei Ss046 hypothetical protein YP_311579.1 2887832 D 300269 CDS YP_311580.1 74313161 3666668 2888188..2888523 1 NC_007384.1 hypothetical protein 2888523 3666668 SSON_2728 Shigella sonnei Ss046 hypothetical protein YP_311580.1 2888188 D 300269 CDS YP_311581.1 74313162 3666669 2888608..2890557 1 NC_007384.1 tail protein 2890557 3666669 SSON_2729 Shigella sonnei Ss046 tail protein YP_311581.1 2888608 D 300269 CDS YP_311582.1 74313163 3666670 2890984..2891487 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2891487 3666670 SSON_2730 Shigella sonnei Ss046 IS1 ORF YP_311582.1 2890984 D 300269 CDS YP_311583.1 74313164 3667174 2891931..2893322 1 NC_007384.1 tail/DNA circulation protein 2893322 3667174 SSON_2731 Shigella sonnei Ss046 tail/DNA circulation protein YP_311583.1 2891931 D 300269 CDS YP_311584.1 74313165 3667175 2893319..2894401 1 NC_007384.1 Code: R; COG: COG4379; tail protein 2894401 3667175 SSON_2732 Shigella sonnei Ss046 tail protein YP_311584.1 2893319 D 300269 CDS YP_311585.1 74313166 3667176 2894379..2894912 1 NC_007384.1 Code: S; COG: COG4384; baseplate assembly protein 2894912 3667176 SSON_2733 Shigella sonnei Ss046 baseplate assembly protein YP_311585.1 2894379 D 300269 CDS YP_311586.1 74313167 3667177 2894918..2895328 1 NC_007384.1 Code: S; COG: COG4381; tail protein 2895328 3667177 SSON_2734 Shigella sonnei Ss046 tail protein YP_311586.1 2894918 D 300269 CDS YP_311587.1 74313168 3667178 2895321..2895995 1 NC_007384.1 head assembly protein 2895995 3667178 SSON_2735 Shigella sonnei Ss046 head assembly protein YP_311587.1 2895321 D 300269 CDS YP_311588.1 74313169 3667179 complement(2895930..2896433) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2896433 3667179 SSON_2736 Shigella sonnei Ss046 IS1 ORF YP_311588.1 2895930 R 300269 CDS YP_311589.1 74313170 3667180 2896788..2897180 1 NC_007384.1 tail protein 2897180 3667180 SSON_2737 Shigella sonnei Ss046 tail protein YP_311589.1 2896788 D 300269 CDS YP_311590.1 74313171 3667181 2897180..2897770 1 NC_007384.1 Code: S; COG: COG3778; tail protein 2897770 3667181 SSON_2738 Shigella sonnei Ss046 tail protein YP_311590.1 2897180 D 300269 CDS YP_311591.1 74313172 3667182 2897757..2898797 1 NC_007384.1 tail fiber protein 2898797 3667182 SSON_2739 Shigella sonnei Ss046 tail fiber protein YP_311591.1 2897757 D 300269 CDS YP_311592.1 74313173 3667183 2898950..2899345 1 NC_007384.1 tail fiber assembly protein 2899345 3667183 SSON_2740 Shigella sonnei Ss046 tail fiber assembly protein YP_311592.1 2898950 D 300269 CDS YP_311593.1 74313174 3667184 2899471..2900637 1 NC_007384.1 tail fiber protein 2900637 3667184 SSON_2741 Shigella sonnei Ss046 tail fiber protein YP_311593.1 2899471 D 300269 CDS YP_311594.1 74313175 3667185 2900588..2901211 1 NC_007384.1 hypothetical protein 2901211 3667185 SSON_2742 Shigella sonnei Ss046 hypothetical protein YP_311594.1 2900588 D 300269 CDS YP_311595.1 74313176 3667186 complement(2901987..2902469) 1 NC_007384.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 2902469 smpB 3667186 smpB Shigella sonnei Ss046 SsrA-binding protein YP_311595.1 2901987 R 300269 CDS YP_311596.1 74313177 3667187 2902601..2903077 1 NC_007384.1 Code: I; COG: COG2867; hypothetical protein 2903077 3667187 SSON_2744 Shigella sonnei Ss046 hypothetical protein YP_311596.1 2902601 D 300269 CDS YP_311597.2 161986472 3667188 2903067..2903357 1 NC_007384.1 Code: S; COG: COG2914; hypothetical protein 2903357 3667188 SSON_2745 Shigella sonnei Ss046 hypothetical protein YP_311597.2 2903067 D 300269 CDS YP_311598.1 74313179 3667189 2903451..2904797 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 2904797 3667189 SSON_2746 Shigella sonnei Ss046 IS4 orf YP_311598.1 2903451 D 300269 CDS YP_311599.1 74313180 3667190 2904817..2905023 1 NC_007384.1 hypothetical protein 2905023 3667190 SSON_2747 Shigella sonnei Ss046 hypothetical protein YP_311599.1 2904817 D 300269 CDS YP_311600.1 74313181 3667191 2905058..2905399 1 NC_007384.1 associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 2905399 yfiA 3667191 yfiA Shigella sonnei Ss046 translation inhibitor protein RaiA YP_311600.1 2905058 D 300269 CDS YP_311602.1 74313183 3667193 2905650..2906810 1 NC_007384.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 2906810 pheA 3667193 pheA Shigella sonnei Ss046 bifunctional chorismate mutase/prephenate dehydratase YP_311602.1 2905650 D 300269 CDS YP_311603.1 74313184 3667214 complement(2906853..2907974) 1 NC_007384.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 2907974 tyrA 3667214 tyrA Shigella sonnei Ss046 bifunctional chorismate mutase/prephenate dehydrogenase YP_311603.1 2906853 R 300269 CDS YP_311604.1 74313185 3667215 complement(2907985..2909055) 1 NC_007384.1 DAHP synthetase; tyrosine repressible; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 2909055 aroF 3667215 aroF Shigella sonnei Ss046 phospho-2-dehydro-3-deoxyheptonate aldolase YP_311604.1 2907985 R 300269 CDS YP_311605.1 74313186 3667216 2909264..2909641 1 NC_007384.1 hypothetical protein 2909641 yfiL 3667216 yfiL Shigella sonnei Ss046 hypothetical protein YP_311605.1 2909264 D 300269 CDS YP_311606.1 74313187 3667217 2909869..2910372 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2910372 3667217 SSON_2754 Shigella sonnei Ss046 IS1 ORF YP_311606.1 2909869 D 300269 CDS YP_311607.1 74313188 3667218 2910556..2911074 1 NC_007384.1 hypothetical protein 2911074 3667218 SSON_2755 Shigella sonnei Ss046 hypothetical protein YP_311607.1 2910556 D 300269 CDS YP_311608.1 74313189 3667219 complement(2911174..2911887) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 2911887 3667219 SSON_2756 Shigella sonnei Ss046 IS600 ORF2 YP_311608.1 2911174 R 300269 CDS YP_311609.1 74313190 3667220 complement(2912028..2912330) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 2912330 3667220 SSON_2757 Shigella sonnei Ss046 IS600 ORF1 YP_311609.1 2912028 R 300269 CDS YP_311610.1 74313191 3667221 complement(2912382..2912585) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 2912585 3667221 SSON_2758 Shigella sonnei Ss046 IS600 ORF1 YP_311610.1 2912382 R 300269 CDS YP_311611.1 74313192 3667222 2912866..2914038 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 2914038 3667222 SSON_2759 Shigella sonnei Ss046 IS21 ORF1 YP_311611.1 2912866 D 300269 CDS YP_311612.1 74313193 3667223 2914038..2914835 1 NC_007384.1 Code: L; COG: COG1484; IS21 ORF2 2914835 3667223 SSON_2760 Shigella sonnei Ss046 IS21 ORF2 YP_311612.1 2914038 D 300269 CDS YP_311613.1 74313194 3667224 2914897..2915946 1 NC_007384.1 Code: T; COG: COG2199; hypothetical protein 2915946 yfiN 3667224 yfiN Shigella sonnei Ss046 hypothetical protein YP_311613.1 2914897 D 300269 CDS YP_311614.1 74313195 3667225 2915962..2916444 1 NC_007384.1 Code: M; COG: COG2885; outer membrane lipoprotein 2916444 yfiB 3667225 yfiB Shigella sonnei Ss046 outer membrane lipoprotein YP_311614.1 2915962 D 300269 CDS YP_311615.1 74313196 3667226 complement(2916521..2916868) 1 NC_007384.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 2916868 rplS 3667226 rplS Shigella sonnei Ss046 50S ribosomal protein L19 YP_311615.1 2916521 R 300269 CDS YP_311616.1 74313197 3667227 complement(2916910..2917677) 1 NC_007384.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 2917677 trmD 3667227 trmD Shigella sonnei Ss046 tRNA (guanine-N(1)-)-methyltransferase YP_311616.1 2916910 R 300269 CDS YP_311617.2 161986471 3667228 complement(2917708..2918256) 1 NC_007384.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 2918256 rimM 3667228 rimM Shigella sonnei Ss046 16S rRNA-processing protein RimM YP_311617.2 2917708 R 300269 CDS YP_311618.1 74313199 3667229 complement(2918275..2918523) 1 NC_007384.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 2918523 rpsP 3667229 rpsP Shigella sonnei Ss046 30S ribosomal protein S16 YP_311618.1 2918275 R 300269 CDS YP_311619.1 74313200 3667230 complement(2918772..2920133) 1 NC_007384.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein 2920133 ffh 3667230 ffh Shigella sonnei Ss046 signal recognition particle protein YP_311619.1 2918772 R 300269 CDS YP_311620.1 74313201 3667231 2920225..2921091 1 NC_007384.1 Code: R; COG: COG4137; hypothetical protein 2921091 3667231 SSON_2768 Shigella sonnei Ss046 hypothetical protein YP_311620.1 2920225 D 300269 CDS YP_311621.2 161986470 3667232 2921202..2922398 1 NC_007384.1 Code: P; COG: COG4536; hypothetical protein 2922398 yfjD 3667232 yfjD Shigella sonnei Ss046 hypothetical protein YP_311621.2 2921202 D 300269 CDS YP_311622.1 74313203 3666711 complement(2922453..2923046) 1 NC_007384.1 phage lambda replication; host DNA synthesis; protein repair; with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 2923046 grpE 3666711 grpE Shigella sonnei Ss046 heat shock protein GrpE YP_311622.1 2922453 R 300269 CDS YP_311623.1 74313204 3666712 2923169..2924047 1 NC_007384.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 2924047 ppnK 3666712 ppnK Shigella sonnei Ss046 inorganic polyphosphate/ATP-NAD kinase YP_311623.1 2923169 D 300269 CDS YP_311624.1 74313205 3666713 2924133..2925794 1 NC_007384.1 Code: L; COG: COG0497; recombination and repair protein 2925794 recN 3666713 recN Shigella sonnei Ss046 recombination and repair protein YP_311624.1 2924133 D 300269 CDS YP_311625.2 161986469 3666714 2925943..2926284 1 NC_007384.1 Code: J; COG: COG2913; hypothetical protein 2926284 smpA 3666714 smpA Shigella sonnei Ss046 hypothetical protein YP_311625.2 2925943 D 300269 CDS YP_311626.1 74313207 3666715 complement(2926343..2926666) 1 NC_007384.1 IS4 orf 2926666 3666715 SSON_2774 Shigella sonnei Ss046 IS4 orf YP_311626.1 2926343 R 300269 CDS YP_311627.2 161986468 3666716 2927053..2927958 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2927958 3666716 SSON_2775 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_311627.2 2927053 D 300269 CDS YP_311628.1 74313209 3666717 complement(2927883..2929025) 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 2929025 3666717 SSON_2776 Shigella sonnei Ss046 IS4 orf YP_311628.1 2927883 R 300269 CDS YP_311629.1 74313210 3666718 complement(2929075..2930319) 1 NC_007384.1 Code: S; COG: COG4695; portal protein 2930319 3666718 SSON_2777 Shigella sonnei Ss046 portal protein YP_311629.1 2929075 R 300269 CDS YP_311630.1 74313211 3666719 complement(2930231..2930413) 1 NC_007384.1 hypothetical protein 2930413 ymfR 3666719 ymfR Shigella sonnei Ss046 hypothetical protein YP_311630.1 2930231 R 300269 CDS YP_311631.1 74313212 3666720 complement(2930425..2932158) 1 NC_007384.1 Code: R; COG: COG4626; hypothetical protein 2932158 ymfN 3666720 ymfN Shigella sonnei Ss046 hypothetical protein YP_311631.1 2930425 R 300269 CDS YP_311632.1 74313213 3666721 complement(2932155..2932649) 1 NC_007384.1 Code: L; COG: COG3747; hypothetical protein 2932649 3666721 SSON_2780 Shigella sonnei Ss046 hypothetical protein YP_311632.1 2932155 R 300269 CDS YP_311633.1 74313214 3666722 complement(2932771..2933121) 1 NC_007384.1 Code: V; COG: COG1403; DNase 2933121 3666722 SSON_2781 Shigella sonnei Ss046 DNase YP_311633.1 2932771 R 300269 CDS YP_311634.1 74313215 3666723 complement(2933164..2933628) 1 NC_007384.1 similar to bacteriophage lambda endopeptidase; endopeptidase-like protein 2933628 ybcT 3666723 ybcT Shigella sonnei Ss046 endopeptidase-like protein YP_311634.1 2933164 R 300269 CDS YP_311635.1 74313216 3666724 complement(2933625..2934122) 1 NC_007384.1 similar to bacteriophage lambda lysozyme; Code: R; COG: COG3772; lysozyme-like protein 2934122 ybcS 3666724 ybcS Shigella sonnei Ss046 lysozyme-like protein YP_311635.1 2933625 R 300269 CDS YP_311636.1 74313217 3666725 complement(2934122..2934337) 1 NC_007384.1 lysis protein S 2934337 3666725 SSON_2784 Shigella sonnei Ss046 lysis protein S YP_311636.1 2934122 R 300269 CDS YP_311637.1 74313218 3666805 complement(2935518..2936279) 1 NC_007384.1 bacteriophage protein 2936279 3666805 SSON_2789 Shigella sonnei Ss046 bacteriophage protein YP_311637.1 2935518 R 300269 CDS YP_311638.1 74313219 3666806 complement(2936562..2936948) 1 NC_007384.1 similar to cryptic prophage protein; antitermination protein Q-like protein 2936948 3666806 SSON_2790 Shigella sonnei Ss046 antitermination protein Q-like protein YP_311638.1 2936562 R 300269 CDS YP_311639.1 74313220 3666807 complement(2936938..2937309) 1 NC_007384.1 encoded by cryptic prophage; Code: L; COG: COG4570; endonuclease 2937309 3666807 SSON_2791 Shigella sonnei Ss046 endonuclease YP_311639.1 2936938 R 300269 CDS YP_311640.1 74313221 3666808 complement(2937309..2937566) 1 NC_007384.1 bacteriophage protein 2937566 3666808 SSON_2792 Shigella sonnei Ss046 bacteriophage protein YP_311640.1 2937309 R 300269 CDS YP_311641.1 74313222 3666809 complement(2937563..2939095) 1 NC_007384.1 Code: L; COG: COG0305; helicase 2939095 3666809 SSON_2793 Shigella sonnei Ss046 helicase YP_311641.1 2937563 R 300269 CDS YP_311642.2 161986467 3666810 complement(2939070..2939975) 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2939975 3666810 SSON_2794 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_311642.2 2939070 R 300269 CDS YP_311643.1 74313224 3666811 complement(2939933..2940298) 1 NC_007384.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 2940298 3666811 SSON_2795 Shigella sonnei Ss046 insertion sequence 2 OrfA protein YP_311643.1 2939933 R 300269 CDS YP_311644.1 74313225 3666813 complement(2942092..2942235) 1 NC_007384.1 hypothetical protein 2942235 3666813 SSON_2797 Shigella sonnei Ss046 hypothetical protein YP_311644.1 2942092 R 300269 CDS YP_311645.1 74313226 3666814 complement(2942664..2944142) 1 NC_007384.1 hypothetical protein 2944142 3666814 SSON_2798 Shigella sonnei Ss046 hypothetical protein YP_311645.1 2942664 R 300269 CDS YP_311646.1 74313227 3666815 2944845..2945348 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2945348 3666815 SSON_2799 Shigella sonnei Ss046 IS1 ORF YP_311646.1 2944845 D 300269 CDS YP_311647.1 74313228 3666817 complement(2945809..2946312) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 2946312 3666817 SSON_2801 Shigella sonnei Ss046 IS1 ORF YP_311647.1 2945809 R 300269 CDS YP_311648.1 74313229 3666818 2946772..2948325 1 NC_007384.1 Code: G; COG: COG0366; hypothetical protein 2948325 3666818 SSON_2802 Shigella sonnei Ss046 hypothetical protein YP_311648.1 2946772 D 300269 CDS YP_311649.2 161986466 3666819 2948661..2949638 1 NC_007384.1 in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 2949638 3666819 SSON_2803 Shigella sonnei Ss046 hypothetical protein YP_311649.2 2948661 D 300269 CDS YP_311650.1 74313231 3666935 2949592..2950926 1 NC_007384.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 2950926 ygaF 3666935 ygaF Shigella sonnei Ss046 hydroxyglutarate oxidase YP_311650.1 2949592 D 300269 CDS YP_311651.1 74313232 3666936 2950949..2952397 1 NC_007384.1 catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; succinate-semialdehyde dehydrogenase I 2952397 gabD 3666936 gabD Shigella sonnei Ss046 succinate-semialdehyde dehydrogenase I YP_311651.1 2950949 D 300269 CDS YP_311652.1 74313233 3666937 2952411..2953691 1 NC_007384.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 2953691 gabT 3666937 gabT Shigella sonnei Ss046 4-aminobutyrate aminotransferase YP_311652.1 2952411 D 300269 CDS YP_311653.1 74313234 3666938 2954002..2955318 1 NC_007384.1 Code: E; COG: COG1113; transport permease of gamma-aminobutyrate 2955318 gabP 3666938 gabP Shigella sonnei Ss046 transport permease of gamma-aminobutyrate YP_311653.1 2954002 D 300269 CDS YP_311654.2 161986465 3666939 2955339..2956001 1 NC_007384.1 regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 2956001 ygaE 3666939 ygaE Shigella sonnei Ss046 DNA-binding transcriptional regulator CsiR YP_311654.2 2955339 D 300269 CDS YP_311655.1 74313236 3666940 complement(2956002..2956451) 1 NC_007384.1 Code: S; COG: COG1652; LysM domain/BON superfamily protein 2956451 ygaU 3666940 ygaU Shigella sonnei Ss046 LysM domain/BON superfamily protein YP_311655.1 2956002 R 300269 CDS YP_311656.1 74313237 3666941 complement(2956535..2956693) 1 NC_007384.1 Code: S; COG: COG0401; hypothetical protein 2956693 3666941 SSON_2810 Shigella sonnei Ss046 hypothetical protein YP_311656.1 2956535 R 300269 CDS YP_311657.1 74313238 3666942 2956876..2957175 1 NC_007384.1 Code: K; COG: COG0640; hypothetical protein 2957175 3666942 SSON_2811 Shigella sonnei Ss046 hypothetical protein YP_311657.1 2956876 D 300269 CDS YP_311658.1 74313239 3666943 2957185..2957709 1 NC_007384.1 Code: P; COG: COG0607; hypothetical protein 2957709 ygaP 3666943 ygaP Shigella sonnei Ss046 hypothetical protein YP_311658.1 2957185 D 300269 CDS YP_311659.1 74313240 3666944 complement(2957756..2958160) 1 NC_007384.1 H-NS-like protein; chaperone activity; possibly involved in RNA splicing; Code: R; COG: COG2916; DNA binding protein 2958160 stpA 3666944 stpA Shigella sonnei Ss046 DNA binding protein YP_311659.1 2957756 R 300269 CDS YP_311660.1 74313241 3666945 2958675..2959871 1 NC_007384.1 Code: L; COG: COG3547; ISSfl2 ORF 2959871 3666945 SSON_2814 Shigella sonnei Ss046 ISSfl2 ORF YP_311660.1 2958675 D 300269 CDS YP_311661.1 74313242 3666946 2960280..2960729 1 NC_007384.1 hypothetical protein 2960729 3666946 SSON_2815 Shigella sonnei Ss046 hypothetical protein YP_311661.1 2960280 D 300269 CDS YP_311662.1 74313243 3666947 complement(2960766..2961110) 1 NC_007384.1 hypothetical protein 2961110 ygaC 3666947 ygaC Shigella sonnei Ss046 hypothetical protein YP_311662.1 2960766 R 300269 CDS YP_311663.1 74313244 3666948 2961250..2961591 1 NC_007384.1 Code: S; COG: COG4575; hypothetical protein 2961591 ygaM 3666948 ygaM Shigella sonnei Ss046 hypothetical protein YP_311663.1 2961250 D 300269 CDS YP_311664.1 74313245 3666949 2961839..2962084 1 NC_007384.1 hydrogen donor; Code: O; COG: COG0695; glutaredoxin-like protein 2962084 nrdH 3666949 nrdH Shigella sonnei Ss046 glutaredoxin-like protein YP_311664.1 2961839 D 300269 CDS YP_311665.1 74313246 3666951 2962464..2964608 1 NC_007384.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2964608 nrdE 3666951 nrdE Shigella sonnei Ss046 ribonucleotide-diphosphate reductase subunit alpha YP_311665.1 2962464 D 300269 CDS YP_311666.1 74313247 3666952 2964618..2965577 1 NC_007384.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 2965577 nrdF 3666952 nrdF Shigella sonnei Ss046 ribonucleotide-diphosphate reductase subunit beta YP_311666.1 2964618 D 300269 CDS YP_311667.1 74313248 3666953 2965933..2967135 1 NC_007384.1 with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding subunit 2967135 proV 3666953 proV Shigella sonnei Ss046 glycine betaine transporter ATP-binding subunit YP_311667.1 2965933 D 300269 CDS YP_311668.1 74313249 3667064 2967128..2968192 1 NC_007384.1 with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 2968192 proW 3667064 proW Shigella sonnei Ss046 glycine betaine transporter membrane protein YP_311668.1 2967128 D 300269 CDS YP_311669.1 74313250 3667065 2968250..2969242 1 NC_007384.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 2969242 proX 3667065 proX Shigella sonnei Ss046 glycine betaine transporter periplasmic subunit YP_311669.1 2968250 D 300269 CDS YP_311670.1 74313251 3667066 2969533..2970717 1 NC_007384.1 major facilitator superfamily; Code: GEPR; COG: COG0477; permease 2970717 3667066 SSON_2825 Shigella sonnei Ss046 permease YP_311670.1 2969533 D 300269 CDS YP_311671.1 74313252 3667067 2970841..2971578 1 NC_007384.1 Code: E; COG: COG1296; hypothetical protein 2971578 3667067 SSON_2826 Shigella sonnei Ss046 hypothetical protein YP_311671.1 2970841 D 300269 CDS YP_311672.1 74313253 3667068 2971568..2971903 1 NC_007384.1 hypothetical protein 2971903 ygaH 3667068 ygaH Shigella sonnei Ss046 hypothetical protein YP_311672.1 2971568 D 300269 CDS YP_311673.1 74313254 3667069 2971994..2972524 1 NC_007384.1 microcin B17 synthesis; DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 2972524 emrR 3667069 emrR Shigella sonnei Ss046 transcriptional repressor MprA YP_311673.1 2971994 D 300269 CDS YP_311674.1 74313255 3667070 2972651..2973823 1 NC_007384.1 Code: V; COG: COG1566; multidrug resistance secretion protein 2973823 emrA 3667070 emrA Shigella sonnei Ss046 multidrug resistance secretion protein YP_311674.1 2972651 D 300269 CDS YP_311675.1 74313256 3667071 2973840..2975378 1 NC_007384.1 multidrug resistance; Code: GEPR; COG: COG0477; membrane translocase 2975378 emrB 3667071 emrB Shigella sonnei Ss046 membrane translocase YP_311675.1 2973840 D 300269 CDS YP_311676.1 74313257 3667072 complement(2975442..2975957) 1 NC_007384.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 2975957 ygaG 3667072 ygaG Shigella sonnei Ss046 S-ribosylhomocysteinase YP_311676.1 2975442 R 300269 CDS YP_311677.1 74313258 3667073 complement(2976107..2977663) 1 NC_007384.1 involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase 2977663 gshA 3667073 gshA Shigella sonnei Ss046 glutamate--cysteine ligase YP_311677.1 2976107 R 300269 CDS YP_311678.1 74313259 3667074 complement(2977736..2978164) 1 NC_007384.1 Code: S; COG: COG1238; hypothetical protein 2978164 3667074 SSON_2833 Shigella sonnei Ss046 hypothetical protein YP_311678.1 2977736 R 300269 CDS YP_311679.1 74313260 3667075 complement(2978161..2978727) 1 NC_007384.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase 2978727 yqaB 3667075 yqaB Shigella sonnei Ss046 fructose-1-phosphatase YP_311679.1 2978161 R 300269 CDS YP_311680.1 74313261 3670619 complement(2980051..2980236) 1 NC_007384.1 affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator 2980236 csrA 3670619 csrA Shigella sonnei Ss046 carbon storage regulator YP_311680.1 2980051 R 300269 CDS YP_311681.1 74313262 3670620 complement(2980471..2983101) 1 NC_007384.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 2983101 alaS 3670620 alaS Shigella sonnei Ss046 alanyl-tRNA synthetase YP_311681.1 2980471 R 300269 CDS YP_311682.1 74313263 3670621 complement(2983229..2983729) 1 NC_007384.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 2983729 recX 3670621 recX Shigella sonnei Ss046 recombination regulator RecX YP_311682.1 2983229 R 300269 CDS YP_311683.1 74313264 3670622 complement(2983957..2985018) 1 NC_007384.1 DNA strand exchange and renaturation; DNA- and ATP-dependent coprotease; catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 2985018 recA 3670622 recA Shigella sonnei Ss046 recombinase A YP_311683.1 2983957 R 300269 CDS YP_311684.1 74313265 3670623 complement(2985098..2985595) 1 NC_007384.1 Code: R; COG: COG1546; competence damage-inducible protein A 2985595 ygaD 3670623 ygaD Shigella sonnei Ss046 competence damage-inducible protein A YP_311684.1 2985098 R 300269 CDS YP_311685.1 74313266 3670624 complement(2985740..2986825) 1 NC_007384.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B 2986825 mltB 3670624 mltB Shigella sonnei Ss046 murein hydrolase B YP_311685.1 2985740 R 300269 CDS YP_311686.1 74313267 3670625 2987081..2987644 1 NC_007384.1 Code: G; COG: COG3730; PTS system glucitol/sorbitol-specific transporter subunit IIC 2987644 srlA 3670625 srlA Shigella sonnei Ss046 PTS system glucitol/sorbitol-specific transporter subunit IIC YP_311686.1 2987081 D 300269 CDS YP_311687.1 74313268 3670626 2987641..2988600 1 NC_007384.1 Code: G; COG: COG3732; PTS system glucitol/sorbitol-specific transporter subunit IIBC 2988600 srlE 3670626 srlE Shigella sonnei Ss046 PTS system glucitol/sorbitol-specific transporter subunit IIBC YP_311687.1 2987641 D 300269 CDS YP_311688.1 74313269 3670627 2988611..2988982 1 NC_007384.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucitol/sorbitol-specific transporter subunit IIA 2988982 srlB 3670627 srlB Shigella sonnei Ss046 PTS system glucitol/sorbitol-specific transporter subunit IIA YP_311688.1 2988611 D 300269 CDS YP_311689.1 74313270 3670629 2989859..2990218 1 NC_007384.1 regulator for glucitol utilization; DNA-binding transcriptional activator GutM 2990218 gutM 3670629 gutM Shigella sonnei Ss046 DNA-binding transcriptional activator GutM YP_311689.1 2989859 D 300269 CDS YP_311690.1 74313271 3670630 2990285..2991058 1 NC_007384.1 regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 2991058 srlR 3670630 srlR Shigella sonnei Ss046 DNA-binding transcriptional repressor SrlR YP_311690.1 2990285 D 300269 CDS YP_311691.2 161986464 3670631 2991051..2992016 1 NC_007384.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 2992016 gutQ 3670631 gutQ Shigella sonnei Ss046 D-arabinose 5-phosphate isomerase YP_311691.2 2991051 D 300269 CDS YP_311692.2 161986463 3670632 complement(2992013..2993527) 1 NC_007384.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcriptional regulator 2993527 ygaA 3670632 ygaA Shigella sonnei Ss046 anaerobic nitric oxide reductase transcriptional regulator YP_311692.2 2992013 R 300269 CDS YP_311693.1 74313274 3670633 2993714..2995153 1 NC_007384.1 detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 2995153 3670633 SSON_2854 Shigella sonnei Ss046 anaerobic nitric oxide reductase flavorubredoxin YP_311693.1 2993714 D 300269 CDS YP_311694.1 74313275 3670634 2995150..2996283 1 NC_007384.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 2996283 ygbD 3670634 ygbD Shigella sonnei Ss046 nitric oxide reductase YP_311694.1 2995150 D 300269 CDS YP_311695.1 74313276 3670635 complement(2996411..2998663) 1 NC_007384.1 Code: O; COG: COG0068; transcriptional regulator 2998663 hypF 3670635 hypF Shigella sonnei Ss046 transcriptional regulator YP_311695.1 2996411 R 300269 CDS YP_311696.1 74313277 3670675 complement(2998816..2999343) 1 NC_007384.1 involved in electron transport from formate to hydrogen; electron transport protein HydN 2999343 hydN 3670675 hydN Shigella sonnei Ss046 electron transport protein HydN YP_311696.1 2998816 R 300269 CDS YP_311697.1 74313278 3670676 complement(2999491..3000504) 1 NC_007384.1 Code: K; COG: COG1609; ascBF operon repressor 3000504 ascG 3670676 ascG Shigella sonnei Ss046 ascBF operon repressor YP_311697.1 2999491 R 300269 CDS YP_311698.1 74313279 3670677 3000761..3002218 1 NC_007384.1 transports specific beta-glucosides; phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system cellobiose/arbutin/salicin-specific transporter subunit IIBC 3002218 ascF 3670677 ascF Shigella sonnei Ss046 PTS system cellobiose/arbutin/salicin-specific transporter subunit IIBC YP_311698.1 3000761 D 300269 CDS YP_311699.1 74313280 3670678 3002227..3003651 1 NC_007384.1 Code: G; COG: COG2723; cryptic 6-phospho-beta-glucosidase 3003651 ascB 3670678 ascB Shigella sonnei Ss046 cryptic 6-phospho-beta-glucosidase YP_311699.1 3002227 D 300269 CDS YP_311700.1 74313281 3670679 complement(3003765..3004184) 1 NC_007384.1 Code: K; COG: COG5499; hypothetical protein 3004184 3670679 SSON_2861 Shigella sonnei Ss046 hypothetical protein YP_311700.1 3003765 R 300269 CDS YP_311701.1 74313282 3670680 complement(3004181..3004492) 1 NC_007384.1 Code: S; COG: COG4680; hypothetical protein 3004492 3670680 SSON_2862 Shigella sonnei Ss046 hypothetical protein YP_311701.1 3004181 R 300269 CDS YP_311702.1 74313283 3670681 complement(3004654..3005427) 1 NC_007384.1 periplasmic or exported protein 3005427 3670681 SSON_2863 Shigella sonnei Ss046 periplasmic or exported protein YP_311702.1 3004654 R 300269 CDS YP_311703.1 74313284 3670682 complement(3005452..3005922) 1 NC_007384.1 involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease 3005922 hycI 3670682 hycI Shigella sonnei Ss046 hydrogenase 3 maturation protease YP_311703.1 3005452 R 300269 CDS YP_311704.1 74313285 3670683 complement(3005915..3006325) 1 NC_007384.1 processing of large subunit (HycE) of hydrogenase 3 (part of the FHL complex); protein Hycprotein H 3006325 hycH 3670683 hycH Shigella sonnei Ss046 protein Hycprotein H YP_311704.1 3005915 R 300269 CDS YP_311705.1 74313286 3670684 complement(3006322..3007089) 1 NC_007384.1 Code: C; COG: COG3260; hydrogenase activity 3007089 hycG 3670684 hycG Shigella sonnei Ss046 hydrogenase activity YP_311705.1 3006322 R 300269 CDS YP_311706.1 74313287 3670685 complement(3007089..3007631) 1 NC_007384.1 part of FHL complex; electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; formate hydrogenlyase complex iron-sulfur subunit 3007631 hycF 3670685 hycF Shigella sonnei Ss046 formate hydrogenlyase complex iron-sulfur subunit YP_311706.1 3007089 R 300269 CDS YP_311707.1 74313288 3670686 complement(3007641..3009338) 1 NC_007384.1 (part of FHL complex); Code: C; COG: COG3261; large subunit of hydrogenase 3 3009338 hycE 3670686 hycE Shigella sonnei Ss046 large subunit of hydrogenase 3 YP_311707.1 3007641 R 300269 CDS YP_311708.1 74313289 3670687 complement(3009356..3010279) 1 NC_007384.1 Code: C; COG: COG0650; membrane-spanning protein of hydrogenase 3 (part of FHL complex) 3010279 hycD 3670687 hycD Shigella sonnei Ss046 membrane-spanning protein of hydrogenase 3 (part of FHL complex) YP_311708.1 3009356 R 300269 CDS YP_311709.1 74313290 3670688 complement(3010282..3012108) 1 NC_007384.1 part of FHL complex; catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 3012108 hycC 3670688 hycC Shigella sonnei Ss046 formate hydrogenlyase subunit 3 YP_311709.1 3010282 R 300269 CDS YP_311710.1 74313291 3670689 complement(3012105..3012716) 1 NC_007384.1 part of formate hydrogenlyase (FHL) complex; Code: C; COG: COG1142; small subunit of hydrogenase-3, iron-sulfur protein 3012716 hycB 3670689 hycB Shigella sonnei Ss046 small subunit of hydrogenase-3, iron-sulfur protein YP_311710.1 3012105 R 300269 CDS YP_311711.1 74313292 3670690 complement(3012841..3013302) 1 NC_007384.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA 3013302 hycA 3670690 hycA Shigella sonnei Ss046 formate hydrogenlyase regulatory protein HycA YP_311711.1 3012841 R 300269 CDS YP_311712.1 74313293 3670691 3013514..3013864 1 NC_007384.1 pleiotrophic effects on 3 hydrogenase isozymes; plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 3013864 hypA 3670691 hypA Shigella sonnei Ss046 hydrogenase nickel incorporation protein YP_311712.1 3013514 D 300269 CDS YP_311713.1 74313294 3670692 3013868..3014740 1 NC_007384.1 functions as nickel donor for large subunit of hydrogenase 3; GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 3014740 hypB 3670692 hypB Shigella sonnei Ss046 hydrogenase nickel incorporation protein HypB YP_311713.1 3013868 D 300269 CDS YP_311714.1 74313295 3670693 3014731..3015003 1 NC_007384.1 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 3015003 hypC 3670693 hypC Shigella sonnei Ss046 hydrogenase assembly chaperone YP_311714.1 3014731 D 300269 CDS YP_311715.1 74313296 3667562 3015003..3016124 1 NC_007384.1 Code: O; COG: COG0409; pleiotrophic effects on 3 hydrogenase isozymes 3016124 hypD 3667562 hypD Shigella sonnei Ss046 pleiotrophic effects on 3 hydrogenase isozymes YP_311715.1 3015003 D 300269 CDS YP_311716.1 74313297 3667563 3016163..3017131 1 NC_007384.1 plays structural role in maturation of all 3 hydrogenases; Code: O; COG: COG0309; hypothetical protein 3017131 hypE 3667563 hypE Shigella sonnei Ss046 hypothetical protein YP_311716.1 3016163 D 300269 CDS YP_311717.1 74313298 3667565 complement(3019319..3019672) 1 NC_007384.1 hypothetical protein 3019672 ygbA 3667565 ygbA Shigella sonnei Ss046 hypothetical protein YP_311717.1 3019319 R 300269 CDS YP_311718.1 74313299 3667566 3019959..3022520 1 NC_007384.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 3022520 mutS 3667566 mutS Shigella sonnei Ss046 DNA mismatch repair protein MutS YP_311718.1 3019959 D 300269 CDS YP_311719.1 74313300 3667568 complement(3023059..3023562) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3023562 3667568 SSON_2882 Shigella sonnei Ss046 IS1 ORF YP_311719.1 3023059 R 300269 CDS YP_311720.1 74313301 3667569 complement(3024110..3024907) 1 NC_007384.1 Code: KG; COG: COG1349; DeoR-type transcriptional regulator 3024907 ygbI 3667569 ygbI Shigella sonnei Ss046 DeoR-type transcriptional regulator YP_311720.1 3024110 R 300269 CDS YP_311721.1 74313302 3667570 3025073..3025981 1 NC_007384.1 Code: I; COG: COG2084; dehydrogenase 3025981 3667570 SSON_2884 Shigella sonnei Ss046 dehydrogenase YP_311721.1 3025073 D 300269 CDS YP_311722.1 74313303 3667571 3025978..3027240 1 NC_007384.1 Code: S; COG: COG3395; hypothetical protein 3027240 3667571 SSON_2885 Shigella sonnei Ss046 hypothetical protein YP_311722.1 3025978 D 300269 CDS YP_311723.1 74313304 3667572 3027237..3027875 1 NC_007384.1 Code: G; COG: COG0235; aldolase 3027875 ygbL 3667572 ygbL Shigella sonnei Ss046 aldolase YP_311723.1 3027237 D 300269 CDS YP_311724.1 74313305 3667573 3027880..3028656 1 NC_007384.1 Code: G; COG: COG3622; hypothetical protein 3028656 ygbM 3667573 ygbM Shigella sonnei Ss046 hypothetical protein YP_311724.1 3027880 D 300269 CDS YP_311725.1 74313306 3667574 3028745..3030109 1 NC_007384.1 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; inner membrane permease YgbN 3030109 3667574 SSON_2888 Shigella sonnei Ss046 inner membrane permease YgbN YP_311725.1 3028745 D 300269 CDS YP_311726.1 74313307 3667575 complement(3030203..3031195) 1 NC_007384.1 synthesis of many growth phase related proteins; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses; RNA polymerase sigma factor RpoS 3031195 rpoS 3667575 rpoS Shigella sonnei Ss046 RNA polymerase sigma factor RpoS YP_311726.1 3030203 R 300269 CDS YP_311727.1 74313308 3667576 complement(3031258..3032397) 1 NC_007384.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD 3032397 nlpD 3667576 nlpD Shigella sonnei Ss046 lipoprotein NlpD YP_311727.1 3031258 R 300269 CDS YP_311728.1 74313309 3667577 complement(3032537..3033163) 1 NC_007384.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase 3033163 pcm 3667577 pcm Shigella sonnei Ss046 protein-L-isoaspartate O-methyltransferase YP_311728.1 3032537 R 300269 CDS YP_311729.1 74313310 3667578 complement(3033157..3033918) 1 NC_007384.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 3033918 surE 3667578 surE Shigella sonnei Ss046 stationary phase survival protein SurE YP_311729.1 3033157 R 300269 CDS YP_311730.1 74313311 3667579 complement(3033899..3034948) 1 NC_007384.1 catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D 3034948 truD 3667579 truD Shigella sonnei Ss046 tRNA pseudouridine synthase D YP_311730.1 3033899 R 300269 CDS YP_311731.1 74313312 3667580 complement(3034945..3035424) 1 NC_007384.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclo diphosphate synthase 3035424 ispF 3667580 ispF Shigella sonnei Ss046 2-C-methyl-D-erythritol 2,4-cyclo diphosphate synthase YP_311731.1 3034945 R 300269 CDS YP_311732.1 74313313 3667581 complement(3035424..3036134) 1 NC_007384.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 3036134 ispD 3667581 ispD Shigella sonnei Ss046 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_311732.1 3035424 R 300269 CDS YP_311733.1 74313314 3667601 complement(3036153..3036464) 1 NC_007384.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB 3036464 ftsB 3667601 ftsB Shigella sonnei Ss046 cell division protein FtsB YP_311733.1 3036153 R 300269 CDS YP_311734.1 74313315 3667602 complement(3036658..3036981) 1 NC_007384.1 hypothetical protein 3036981 ygbE 3667602 ygbE Shigella sonnei Ss046 hypothetical protein YP_311734.1 3036658 R 300269 CDS YP_311735.1 74313316 3667603 complement(3037031..3037636) 1 NC_007384.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase 3037636 cysC 3667603 cysC Shigella sonnei Ss046 adenylylsulfate kinase YP_311735.1 3037031 R 300269 CDS YP_311736.1 74313317 3667604 complement(3037636..3039063) 1 NC_007384.1 ATP:sulfate adenylyltransferase; probably a GTPase; may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 3039063 cysN 3667604 cysN Shigella sonnei Ss046 sulfate adenylyltransferase subunit 1 YP_311736.1 3037636 R 300269 CDS YP_311737.1 74313318 3667605 complement(3039065..3039973) 1 NC_007384.1 ATP:sulfate adenylyltransferase; with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 3039973 cysD 3667605 cysD Shigella sonnei Ss046 sulfate adenylyltransferase subunit 2 YP_311737.1 3039065 R 300269 CDS YP_311738.1 74313319 3667606 3040225..3041262 1 NC_007384.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase 3041262 iap 3667606 iap Shigella sonnei Ss046 alkaline phosphatase YP_311738.1 3040225 D 300269 CDS YP_311739.1 74313320 3667607 complement(3041530..3041823) 1 NC_007384.1 hypothetical protein 3041823 ygbF 3667607 ygbF Shigella sonnei Ss046 hypothetical protein YP_311739.1 3041530 R 300269 CDS YP_311740.1 74313321 3667609 complement(3042740..3043144) 1 NC_007384.1 hypothetical protein 3043144 ygcH 3667609 ygcH Shigella sonnei Ss046 hypothetical protein YP_311740.1 3042740 R 300269 CDS YP_311741.1 74313322 3667610 3043455..3044651 1 NC_007384.1 Code: L; COG: COG3547; ISSfl2 ORF 3044651 3667610 SSON_2905 Shigella sonnei Ss046 ISSfl2 ORF YP_311741.1 3043455 D 300269 CDS YP_311742.1 74313323 3667611 complement(3044822..3045568) 1 NC_007384.1 hypothetical protein 3045568 3667611 SSON_2906 Shigella sonnei Ss046 hypothetical protein YP_311742.1 3044822 R 300269 CDS YP_311743.1 74313324 3667612 complement(3045579..3046634) 1 NC_007384.1 hypothetical protein 3046634 yghJ 3667612 yghJ Shigella sonnei Ss046 hypothetical protein YP_311743.1 3045579 R 300269 CDS YP_311744.1 74313325 3667613 complement(3046646..3046906) 1 NC_007384.1 hypothetical protein 3046906 3667613 SSON_2908 Shigella sonnei Ss046 hypothetical protein YP_311744.1 3046646 R 300269 CDS YP_311745.1 74313326 3667614 3047037..3047339 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 3047339 3667614 SSON_2909 Shigella sonnei Ss046 IS600 ORF1 YP_311745.1 3047037 D 300269 CDS YP_311746.1 74313327 3667615 3047480..3048193 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 3048193 3667615 SSON_2910 Shigella sonnei Ss046 IS600 ORF2 YP_311746.1 3047480 D 300269 CDS YP_311747.1 74313328 3667616 complement(3048234..3048449) 1 NC_007384.1 hypothetical protein 3048449 3667616 SSON_2911 Shigella sonnei Ss046 hypothetical protein YP_311747.1 3048234 R 300269 CDS YP_311748.1 74313329 3667617 complement(3048446..3048775) 1 NC_007384.1 hypothetical protein 3048775 3667617 SSON_2912 Shigella sonnei Ss046 hypothetical protein YP_311748.1 3048446 R 300269 CDS YP_311749.1 74313330 3667618 complement(3048793..3050007) 1 NC_007384.1 hypothetical protein 3050007 3667618 SSON_2913 Shigella sonnei Ss046 hypothetical protein YP_311749.1 3048793 R 300269 CDS YP_311750.1 74313331 3667619 complement(3050105..3052762) 1 NC_007384.1 Code: R; COG: COG1203; helicase 3052762 ygcB 3667619 ygcB Shigella sonnei Ss046 helicase YP_311750.1 3050105 R 300269 CDS YP_311751.1 74313332 3667692 complement(3053416..3054150) 1 NC_007384.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 3054150 cysH 3667692 cysH Shigella sonnei Ss046 phosphoadenosine phosphosulfate reductase YP_311751.1 3053416 R 300269 CDS YP_311752.1 74313333 3667693 complement(3054225..3055937) 1 NC_007384.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta 3055937 cysI 3667693 cysI Shigella sonnei Ss046 sulfite reductase subunit beta YP_311752.1 3054225 R 300269 CDS YP_311753.1 74313334 3667694 complement(3055937..3057736) 1 NC_007384.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha 3057736 cysJ 3667694 cysJ Shigella sonnei Ss046 sulfite reductase subunit alpha YP_311753.1 3055937 R 300269 CDS YP_311754.1 74313335 3667695 3058052..3058417 1 NC_007384.1 Code: H; COG: COG0720; 6-pyruvoyl tetrahydrobiopterin synthase 3058417 ygcM 3667695 ygcM Shigella sonnei Ss046 6-pyruvoyl tetrahydrobiopterin synthase YP_311754.1 3058052 D 300269 CDS YP_311755.1 74313336 3667696 3058465..3059766 1 NC_007384.1 Code: C; COG: COG0644; hypothetical protein 3059766 ygcN 3667696 ygcN Shigella sonnei Ss046 hypothetical protein YP_311755.1 3058465 D 300269 CDS YP_311756.1 74313337 3667697 3059721..3060017 1 NC_007384.1 Code: C; COG: COG2440; hypothetical protein 3060017 ygcO 3667697 ygcO Shigella sonnei Ss046 hypothetical protein YP_311756.1 3059721 D 300269 CDS YP_311757.1 74313338 3667698 3060034..3060609 1 NC_007384.1 Code: K; COG: COG1954; anti-terminator regulatory protein 3060609 ygcP 3667698 ygcP Shigella sonnei Ss046 anti-terminator regulatory protein YP_311757.1 3060034 D 300269 CDS YP_311758.1 74313339 3667699 complement(3060757..3061650) 1 NC_007384.1 Code: C; COG: COG2025; flavoprotein 3061650 ygcQ 3667699 ygcQ Shigella sonnei Ss046 flavoprotein YP_311758.1 3060757 R 300269 CDS YP_311759.1 74313340 3667700 complement(3061614..3062399) 1 NC_007384.1 Code: C; COG: COG2086; transporter 3062399 ygcR 3667700 ygcR Shigella sonnei Ss046 transporter YP_311759.1 3061614 R 300269 CDS YP_311760.1 74313341 3667701 complement(3062371..3063780) 1 NC_007384.1 Code: GEPR; COG: COG0477; transporter 3063780 ygcS 3667701 ygcS Shigella sonnei Ss046 transporter YP_311760.1 3062371 R 300269 CDS YP_311761.1 74313342 3667702 complement(3063802..3064596) 1 NC_007384.1 Code: C; COG: COG0277; hypothetical protein 3064596 3667702 SSON_2925 Shigella sonnei Ss046 hypothetical protein YP_311761.1 3063802 R 300269 CDS YP_311762.1 74313343 3667704 3066460..3067737 1 NC_007384.1 Code: GEPR; COG: COG0477; transporter 3067737 yqcE 3667704 yqcE Shigella sonnei Ss046 transporter YP_311762.1 3066460 D 300269 CDS YP_311763.1 74313344 3667706 complement(3069449..3069952) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3069952 3667706 SSON_2929 Shigella sonnei Ss046 IS1 ORF YP_311763.1 3069449 R 300269 CDS YP_311764.1 74313345 3667707 complement(3070990..3071661) 1 NC_007384.1 Code: O; COG: COG0602; hypothetical protein 3071661 ygcF 3667707 ygcF Shigella sonnei Ss046 hypothetical protein YP_311764.1 3070990 R 300269 CDS YP_311765.1 74313346 3667708 3071962..3072264 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 3072264 3667708 SSON_2931 Shigella sonnei Ss046 IS600 ORF1 YP_311765.1 3071962 D 300269 CDS YP_311766.1 74313347 3667709 3072405..3073118 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 3073118 3667709 SSON_2932 Shigella sonnei Ss046 IS600 ORF2 YP_311766.1 3072405 D 300269 CDS YP_311767.1 74313348 3667710 3073221..3073970 1 NC_007384.1 Code: R; COG: COG1512; hypothetical protein 3073970 ygcG 3667710 ygcG Shigella sonnei Ss046 hypothetical protein YP_311767.1 3073221 D 300269 CDS YP_311768.1 74313349 3667711 complement(3073981..3074484) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3074484 3667711 SSON_2934 Shigella sonnei Ss046 IS1 ORF YP_311768.1 3073981 R 300269 CDS YP_311769.1 74313350 3667979 3074969..3076315 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 3076315 3667979 SSON_2935 Shigella sonnei Ss046 IS4 orf YP_311769.1 3074969 D 300269 CDS YP_311770.1 74313351 3667980 complement(3076370..3077668) 1 NC_007384.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 3077668 eno 3667980 eno Shigella sonnei Ss046 phosphopyruvate hydratase YP_311770.1 3076370 R 300269 CDS YP_311771.1 74313352 3667981 complement(3077756..3079393) 1 NC_007384.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 3079393 pyrG 3667981 pyrG Shigella sonnei Ss046 CTP synthetase YP_311771.1 3077756 R 300269 CDS YP_311772.1 74313353 3667982 complement(3079621..3080412) 1 NC_007384.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase 3080412 mazG 3667982 mazG Shigella sonnei Ss046 nucleoside triphosphate pyrophosphohydrolase YP_311772.1 3079621 R 300269 CDS YP_311773.1 74313354 3667983 complement(3080483..3080818) 1 NC_007384.1 MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA 3080818 chpA 3667983 chpA Shigella sonnei Ss046 toxin ChpA YP_311773.1 3080483 R 300269 CDS YP_311774.1 74313355 3667984 complement(3080818..3081066) 1 NC_007384.1 part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE 3081066 chpR 3667984 chpR Shigella sonnei Ss046 antitoxin MazE YP_311774.1 3080818 R 300269 CDS YP_311775.1 74313356 3667985 complement(3081144..3083378) 1 NC_007384.1 regulation of RNA synthesis; stringent factor; GTP pyrophosphokinase; (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase 3083378 relA 3667985 relA Shigella sonnei Ss046 GDP/GTP pyrophosphokinase YP_311775.1 3081144 R 300269 CDS YP_311776.1 74313357 3667986 complement(3083426..3084727) 1 NC_007384.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 3084727 rumA 3667986 rumA Shigella sonnei Ss046 23S rRNA 5-methyluridine methyltransferase YP_311776.1 3083426 R 300269 CDS YP_311777.1 74313358 3667987 3084784..3087540 1 NC_007384.1 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; hybrid sensory histidine kinase BarA 3087540 barA 3667987 barA Shigella sonnei Ss046 hybrid sensory histidine kinase BarA YP_311777.1 3084784 D 300269 CDS YP_311778.1 74313359 3667988 complement(3087772..3089112) 1 NC_007384.1 Code: MR; COG: COG4948; glucarate dehydratase 3089112 ygcX 3667988 ygcX Shigella sonnei Ss046 glucarate dehydratase YP_311778.1 3087772 R 300269 CDS YP_311779.1 74313360 3667989 complement(3089133..3090473) 1 NC_007384.1 Code: MR; COG: COG4948; glucarate dehydratase 3090473 ygcY 3667989 ygcY Shigella sonnei Ss046 glucarate dehydratase YP_311779.1 3089133 R 300269 CDS YP_311780.1 74313361 3667990 complement(3090475..3091827) 1 NC_007384.1 Code: GEPR; COG: COG0477; transporter 3091827 3667990 SSON_2946 Shigella sonnei Ss046 transporter YP_311780.1 3090475 R 300269 CDS YP_311781.1 74313362 3667991 complement(3092262..3092711) 1 NC_007384.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 3092711 3667991 SSON_2947 Shigella sonnei Ss046 flavodoxin YP_311781.1 3092262 R 300269 CDS YP_311782.1 74313363 3667992 complement(3092729..3093511) 1 NC_007384.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C 3093511 yqcB 3667992 yqcB Shigella sonnei Ss046 tRNA pseudouridine synthase C YP_311782.1 3092729 R 300269 CDS YP_311783.1 74313364 3667993 complement(3093511..3093840) 1 NC_007384.1 Code: S; COG: COG3098; hypothetical protein 3093840 3667993 SSON_2949 Shigella sonnei Ss046 hypothetical protein YP_311783.1 3093511 R 300269 CDS YP_311784.1 74313365 3667994 complement(3094462..3095007) 1 NC_007384.1 SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd 3095007 syd 3667994 syd Shigella sonnei Ss046 SecY interacting protein Syd YP_311784.1 3094462 R 300269 CDS YP_311785.1 74313366 3667995 3095075..3095923 1 NC_007384.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 3095923 queF 3667995 queF Shigella sonnei Ss046 7-cyano-7-deazaguanine reductase YP_311785.1 3095075 D 300269 CDS YP_311786.1 74313367 3667996 3096035..3097399 1 NC_007384.1 Code: R; COG: COG1611; hypothetical protein 3097399 ygdH 3667996 ygdH Shigella sonnei Ss046 hypothetical protein YP_311786.1 3096035 D 300269 CDS YP_311787.1 74313368 3667997 3097955..3099244 1 NC_007384.1 Code: E; COG: COG0814; serine transporter 3099244 sdaC 3667997 sdaC Shigella sonnei Ss046 serine transporter YP_311787.1 3097955 D 300269 CDS YP_311788.1 74313369 3667998 3099302..3100669 1 NC_007384.1 deaminase; L-SD2; Code: E; COG: COG1760; L-serine dehydratase 3100669 sdaB 3667998 sdaB Shigella sonnei Ss046 L-serine dehydratase YP_311788.1 3099302 D 300269 CDS YP_311789.1 74313370 3667999 3100691..3101536 1 NC_007384.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 3101536 xni 3667999 xni Shigella sonnei Ss046 exonuclease IX YP_311789.1 3100691 D 300269 CDS YP_311790.1 74313371 3668000 complement(3101641..3102792) 1 NC_007384.1 Code: C; COG: COG1454; L-1,2-propanediol oxidoreductase 3102792 fucO 3668000 fucO Shigella sonnei Ss046 L-1,2-propanediol oxidoreductase YP_311790.1 3101641 R 300269 CDS YP_311791.1 74313372 3668001 complement(3102817..3103464) 1 NC_007384.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 3103464 fucA 3668001 fucA Shigella sonnei Ss046 L-fuculose phosphate aldolase YP_311791.1 3102817 R 300269 CDS YP_311792.1 74313373 3668002 3104011..3105327 1 NC_007384.1 Code: G; COG: COG0738; L-fucose transporter 3105327 fucP 3668002 fucP Shigella sonnei Ss046 L-fucose transporter YP_311792.1 3104011 D 300269 CDS YP_311793.1 74313374 3668004 3107214..3108662 1 NC_007384.1 Code: G; COG: COG1070; L-fuculokinase 3108662 fucK 3668004 fucK Shigella sonnei Ss046 L-fuculokinase YP_311793.1 3107214 D 300269 CDS YP_311794.1 74313375 3668005 3108664..3109086 1 NC_007384.1 Code: G; COG: COG4154; protein of fucose operon 3109086 fucU 3668005 fucU Shigella sonnei Ss046 protein of fucose operon YP_311794.1 3108664 D 300269 CDS YP_311795.1 74313376 3668006 3109144..3109875 1 NC_007384.1 regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 3109875 fucR 3668006 fucR Shigella sonnei Ss046 DNA-binding transcriptional activator FucR YP_311795.1 3109144 D 300269 CDS YP_311796.1 74313377 3668007 complement(3109919..3111019) 1 NC_007384.1 Code: R; COG: COG2933; RNA 2'-O-ribose methyltransferase 3111019 ygdE 3668007 ygdE Shigella sonnei Ss046 RNA 2'-O-ribose methyltransferase YP_311796.1 3109919 R 300269 CDS YP_311797.1 74313378 3668008 complement(3111012..3111407) 1 NC_007384.1 Code: S; COG: COG2363; hypothetical protein 3111407 ygdD 3668008 ygdD Shigella sonnei Ss046 hypothetical protein YP_311797.1 3111012 R 300269 CDS YP_311798.1 74313379 3668009 complement(3111426..3112343) 1 NC_007384.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA 3112343 gcvA 3668009 gcvA Shigella sonnei Ss046 DNA-binding transcriptional activator GcvA YP_311798.1 3111426 R 300269 CDS YP_311799.1 74313380 3668010 complement(3112694..3112924) 1 NC_007384.1 hypothetical protein 3112924 3668010 SSON_2966 Shigella sonnei Ss046 hypothetical protein YP_311799.1 3112694 R 300269 CDS YP_311800.1 74313381 3668011 3113113..3114318 1 NC_007384.1 Code: E; COG: COG0520; cysteine sulfinate desulfinase 3114318 3668011 SSON_2967 Shigella sonnei Ss046 cysteine sulfinate desulfinase YP_311800.1 3113113 D 300269 CDS YP_311801.1 74313382 3668012 3114318..3114761 1 NC_007384.1 Code: R; COG: COG2166; hypothetical protein 3114761 ygdK 3668012 ygdK Shigella sonnei Ss046 hypothetical protein YP_311801.1 3114318 D 300269 CDS YP_311802.1 74313383 3668013 complement(3114812..3115618) 1 NC_007384.1 Code: H; COG: COG1179; hypothetical protein 3115618 ygdL 3668013 ygdL Shigella sonnei Ss046 hypothetical protein YP_311802.1 3114812 R 300269 CDS YP_311803.1 74313384 3668014 complement(3115695..3116792) 1 NC_007384.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A 3116792 mltA 3668014 mltA Shigella sonnei Ss046 murein transglycosylase A YP_311803.1 3115695 R 300269 CDS YP_311804.1 74313385 3668018 complement(3117372..3118715) 1 NC_007384.1 Code: M; COG: COG0860; amidase 3118715 3668018 SSON_2974 Shigella sonnei Ss046 amidase YP_311804.1 3117372 R 300269 CDS YP_311805.1 74313386 3668019 3118857..3120188 1 NC_007384.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 3120188 argA 3668019 argA Shigella sonnei Ss046 N-acetylglutamate synthase YP_311805.1 3118857 D 300269 CDS YP_311806.1 74313387 3668020 complement(3120250..3122076) 1 NC_007384.1 ssDNA endonuclease; helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha 3122076 recD 3668020 recD Shigella sonnei Ss046 exonuclease V subunit alpha YP_311806.1 3120250 R 300269 CDS YP_311807.1 74313388 3668021 complement(3122076..3125618) 1 NC_007384.1 ssDNA endonuclease; helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta 3125618 recB 3668021 recB Shigella sonnei Ss046 exonuclease V subunit beta YP_311807.1 3122076 R 300269 CDS YP_311808.1 74313389 3668022 complement(3125611..3128499) 1 NC_007384.1 Code: O; COG: COG1025; protease III 3128499 ptr 3668022 ptr Shigella sonnei Ss046 protease III YP_311808.1 3125611 R 300269 CDS YP_311809.1 74313390 3668023 complement(3128675..3132043) 1 NC_007384.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma 3132043 recC 3668023 recC Shigella sonnei Ss046 exonuclease V subunit gamma YP_311809.1 3128675 R 300269 CDS YP_311810.1 74313391 3668024 complement(3132056..3132379) 1 NC_007384.1 Code: NU; COG: COG4967; hypothetical protein 3132379 ppdC 3668024 ppdC Shigella sonnei Ss046 hypothetical protein YP_311810.1 3132056 R 300269 CDS YP_311811.2 161986462 3668025 complement(3132364..3132771) 1 NC_007384.1 hypothetical protein 3132771 ygdB 3668025 ygdB Shigella sonnei Ss046 hypothetical protein YP_311811.2 3132364 R 300269 CDS YP_311812.1 74313393 3668026 complement(3132768..3133331) 1 NC_007384.1 Code: U; COG: COG4795; hypothetical protein 3133331 ppdB 3668026 ppdB Shigella sonnei Ss046 hypothetical protein YP_311812.1 3132768 R 300269 CDS YP_311813.1 74313394 3668027 complement(3133322..3133792) 1 NC_007384.1 Code: NU; COG: COG2165; hypothetical protein 3133792 ppdA 3668027 ppdA Shigella sonnei Ss046 hypothetical protein YP_311813.1 3133322 R 300269 CDS YP_311814.1 74313395 3668028 complement(3133977..3134771) 1 NC_007384.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 3134771 thyA 3668028 thyA Shigella sonnei Ss046 thymidylate synthase YP_311814.1 3133977 R 300269 CDS YP_311815.1 74313396 3668029 complement(3134778..3135653) 1 NC_007384.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 3135653 lgt 3668029 lgt Shigella sonnei Ss046 prolipoprotein diacylglyceryl transferase YP_311815.1 3134778 R 300269 CDS YP_311816.1 74313397 3668030 complement(3135804..3138050) 1 NC_007384.1 transcriptional regulator (with NPR and NTR proteins); member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain-containing protein 3138050 ptsP 3668030 ptsP Shigella sonnei Ss046 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain-containing protein YP_311816.1 3135804 R 300269 CDS YP_311817.1 74313398 3668031 complement(3138063..3138593) 1 NC_007384.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 3138593 ygdP 3668031 ygdP Shigella sonnei Ss046 dinucleoside polyphosphate hydrolase YP_311817.1 3138063 R 300269 CDS YP_311818.1 74313399 3668032 3139278..3139967 1 NC_007384.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 3139967 mutH 3668032 mutH Shigella sonnei Ss046 DNA mismatch repair protein YP_311818.1 3139278 D 300269 CDS YP_311819.1 74313400 3668033 3140036..3140749 1 NC_007384.1 Code: P; COG: COG0861; transporter 3140749 3668033 SSON_2989 Shigella sonnei Ss046 transporter YP_311819.1 3140036 D 300269 CDS YP_311820.1 74313401 3668165 3140887..3141105 1 NC_007384.1 hypothetical protein 3141105 3668165 SSON_2990 Shigella sonnei Ss046 hypothetical protein YP_311820.1 3140887 D 300269 CDS YP_311821.1 74313402 3668166 complement(3141198..3141911) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 3141911 3668166 SSON_2991 Shigella sonnei Ss046 IS600 ORF2 YP_311821.1 3141198 R 300269 CDS YP_311822.1 74313403 3668167 complement(3142052..3142354) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 3142354 3668167 SSON_2992 Shigella sonnei Ss046 IS600 ORF1 YP_311822.1 3142052 R 300269 CDS YP_311823.1 74313404 3668168 3142462..3143808 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 3143808 3668168 SSON_2993 Shigella sonnei Ss046 IS4 orf YP_311823.1 3142462 D 300269 CDS YP_311824.1 74313405 3668169 3143919..3144959 1 NC_007384.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; aldo-keto reductase 3144959 tas 3668169 tas Shigella sonnei Ss046 aldo-keto reductase YP_311824.1 3143919 D 300269 CDS YP_311825.1 74313406 3668170 complement(3144991..3146184) 1 NC_007384.1 Code: GEPR; COG: COG0477; lysophospholipid transporter LplT 3146184 ygeD 3668170 ygeD Shigella sonnei Ss046 lysophospholipid transporter LplT YP_311825.1 3144991 R 300269 CDS YP_311826.1 74313407 3668171 complement(3146177..3148336) 1 NC_007384.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase 3148336 aas 3668171 aas Shigella sonnei Ss046 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase YP_311826.1 3146177 R 300269 CDS YP_311827.1 74313408 3668172 3148922..3149953 1 NC_007384.1 controls transcription of galETKM; DNA-binding transcriptional regulator GalR 3149953 galR 3668172 galR Shigella sonnei Ss046 DNA-binding transcriptional regulator GalR YP_311827.1 3148922 D 300269 CDS YP_311828.1 74313409 3668173 complement(3149960..3151222) 1 NC_007384.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase 3151222 lysA 3668173 lysA Shigella sonnei Ss046 diaminopimelate decarboxylase YP_311828.1 3149960 R 300269 CDS YP_311829.1 74313410 3668174 3151344..3152279 1 NC_007384.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; LysR family transcriptional regulator 3152279 lysR 3668174 lysR Shigella sonnei Ss046 LysR family transcriptional regulator YP_311829.1 3151344 D 300269 CDS YP_311830.1 74313411 3668176 complement(3153044..3154462) 1 NC_007384.1 Code: GEPR; COG: COG0477; low-affinity L-arabinose transport system proton symport protein 3154462 araE 3668176 araE Shigella sonnei Ss046 low-affinity L-arabinose transport system proton symport protein YP_311830.1 3153044 R 300269 CDS YP_311831.1 74313412 3668177 complement(3154779..3155540) 1 NC_007384.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase 3155540 kduD 3668177 kduD Shigella sonnei Ss046 2-deoxy-D-gluconate 3-dehydrogenase YP_311831.1 3154779 R 300269 CDS YP_311832.1 74313413 3668178 complement(3155605..3156441) 1 NC_007384.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase 3156441 kduI 3668178 kduI Shigella sonnei Ss046 5-keto-4-deoxyuronate isomerase YP_311832.1 3155605 R 300269 CDS YP_311833.2 161986461 3668179 complement(3156728..3157909) 1 NC_007384.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 3157909 yqeF 3668179 yqeF Shigella sonnei Ss046 acetyl-CoA acetyltransferase YP_311833.2 3156728 R 300269 CDS YP_311834.1 74313415 3668180 3158164..3159393 1 NC_007384.1 Code: E; COG: COG0814; transporter protein 3159393 3668180 SSON_3005 Shigella sonnei Ss046 transporter protein YP_311834.1 3158164 D 300269 CDS YP_311835.1 74313416 3668181 3159793..3160485 1 NC_007384.1 Code: K; COG: COG2771; hypothetical protein 3160485 yqeH 3668181 yqeH Shigella sonnei Ss046 hypothetical protein YP_311835.1 3159793 D 300269 CDS YP_311836.1 74313417 3668183 complement(3161142..3161645) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3161645 3668183 SSON_3008 Shigella sonnei Ss046 IS1 ORF YP_311836.1 3161142 R 300269 CDS YP_311837.1 74313418 3668184 3162385..3162879 1 NC_007384.1 hypothetical protein 3162879 yqeJ 3668184 yqeJ Shigella sonnei Ss046 hypothetical protein YP_311837.1 3162385 D 300269 CDS YP_311838.1 74313419 3668906 3163883..3164320 1 NC_007384.1 hypothetical protein 3164320 ygeF 3668906 ygeF Shigella sonnei Ss046 hypothetical protein YP_311838.1 3163883 D 300269 CDS YP_311839.1 74313420 3668907 3164598..3165089 1 NC_007384.1 Code: R; COG: COG0457; hypothetical protein 3165089 ygeG 3668907 ygeG Shigella sonnei Ss046 hypothetical protein YP_311839.1 3164598 D 300269 CDS YP_311840.1 74313421 3668908 3165971..3166336 1 NC_007384.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3166336 3668908 SSON_3012 Shigella sonnei Ss046 insertion sequence 2 OrfA protein YP_311840.1 3165971 D 300269 CDS YP_311841.2 161986460 3668909 3166294..3167199 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3167199 3668909 SSON_3013 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_311841.2 3166294 D 300269 CDS YP_311842.1 74313423 3668910 complement(3167033..3168520) 1 NC_007384.1 hypothetical protein 3168520 3668910 SSON_3014 Shigella sonnei Ss046 hypothetical protein YP_311842.1 3167033 R 300269 CDS YP_311843.1 74313424 3668912 complement(3168831..3169586) 1 NC_007384.1 Code: M; COG: COG0739; lipoprotein 3169586 3668912 SSON_3016 Shigella sonnei Ss046 lipoprotein YP_311843.1 3168831 R 300269 CDS YP_311844.1 74313425 3668913 3170040..3172298 1 NC_007384.1 molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 3172298 3668913 SSON_3017 Shigella sonnei Ss046 xanthine dehydrogenase subunit XdhA YP_311844.1 3170040 D 300269 CDS YP_311845.1 74313426 3668914 3172309..3173187 1 NC_007384.1 FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 3173187 ygeT 3668914 ygeT Shigella sonnei Ss046 xanthine dehydrogenase subunit XdhB YP_311845.1 3172309 D 300269 CDS YP_311846.1 74313427 3668915 3173184..3173663 1 NC_007384.1 iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 3173663 3668915 SSON_3019 Shigella sonnei Ss046 xanthine dehydrogenase subunit XdhC YP_311846.1 3173184 D 300269 CDS YP_311847.1 74313428 3668916 complement(3173703..3175481) 1 NC_007384.1 Code: KT; COG: COG3829; transcriptional regulator 3175481 ygeV 3668916 ygeV Shigella sonnei Ss046 transcriptional regulator YP_311847.1 3173703 R 300269 CDS YP_311848.1 74313429 3668917 3176029..3177147 1 NC_007384.1 Code: E; COG: COG0078; aspartate/ornithine carbamoyltransferase 3177147 ygeW 3668917 ygeW Shigella sonnei Ss046 aspartate/ornithine carbamoyltransferase YP_311848.1 3176029 D 300269 CDS YP_311849.1 74313430 3668918 3177205..3178401 1 NC_007384.1 catalyzes the formation of pyruvate from 2,3-diaminopropionate; diaminopropionate ammonia-lyase 3178401 ygeX 3668918 ygeX Shigella sonnei Ss046 diaminopropionate ammonia-lyase YP_311849.1 3177205 D 300269 CDS YP_311850.1 74313431 3668919 3178459..3179670 1 NC_007384.1 Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases; peptidase 3179670 ygeY 3668919 ygeY Shigella sonnei Ss046 peptidase YP_311850.1 3178459 D 300269 CDS YP_311851.1 74313432 3668921 3181155..3182087 1 NC_007384.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 3182087 yqeA 3668921 yqeA Shigella sonnei Ss046 carbamate kinase YP_311851.1 3181155 D 300269 CDS YP_311852.1 74313433 3668922 complement(3182128..3183753) 1 NC_007384.1 Code: O; COG: COG1975; synthase 3183753 3668922 SSON_3026 Shigella sonnei Ss046 synthase YP_311852.1 3182128 R 300269 CDS YP_311853.1 74313434 3668923 complement(3183801..3184508) 1 NC_007384.1 hypothetical protein 3184508 3668923 SSON_3027 Shigella sonnei Ss046 hypothetical protein YP_311853.1 3183801 R 300269 CDS YP_311854.1 74313435 3668982 3184674..3185252 1 NC_007384.1 Code: R; COG: COG2068; hypothetical protein 3185252 ygfJ 3668982 ygfJ Shigella sonnei Ss046 hypothetical protein YP_311854.1 3184674 D 300269 CDS YP_311855.1 74313436 3668984 complement(3187376..3188722) 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 3188722 3668984 SSON_3030 Shigella sonnei Ss046 IS4 orf YP_311855.1 3187376 R 300269 CDS YP_311856.1 74313437 3668985 complement(3188809..3189522) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 3189522 3668985 SSON_3031 Shigella sonnei Ss046 IS600 ORF2 YP_311856.1 3188809 R 300269 CDS YP_311857.1 74313438 3668986 complement(3189663..3189965) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 3189965 3668986 SSON_3032 Shigella sonnei Ss046 IS600 ORF1 YP_311857.1 3189663 R 300269 CDS YP_311858.2 161986459 3668987 3191380..3192708 1 NC_007384.1 in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS; chlorohydrolase/aminohydrolase 3192708 3668987 SSON_3033 Shigella sonnei Ss046 chlorohydrolase/aminohydrolase YP_311858.2 3191380 D 300269 CDS YP_311859.1 74313440 3668988 3192759..3193538 1 NC_007384.1 with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain; selenate reductase subunit YgfM 3193538 3668988 SSON_3034 Shigella sonnei Ss046 selenate reductase subunit YgfM YP_311859.1 3192759 D 300269 CDS YP_311860.2 228861780 3668989 3193535..3196474 1 NC_007384.1 with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration; selenate reductase subunit YgfN 3196474 3668989 SSON_3035 Shigella sonnei Ss046 selenate reductase subunit YgfN YP_311860.2 3193535 D 300269 CDS YP_311861.1 74313442 3668990 3196296..3196721 1 NC_007384.1 hypothetical protein 3196721 3668990 SSON_3036 Shigella sonnei Ss046 hypothetical protein YP_311861.1 3196296 D 300269 CDS YP_311862.1 74313443 3668991 3196757..3197008 1 NC_007384.1 hypothetical protein 3197008 3668991 SSON_3037 Shigella sonnei Ss046 hypothetical protein YP_311862.1 3196757 D 300269 CDS YP_311863.1 74313444 3668992 complement(3197176..3197667) 1 NC_007384.1 Code: C; COG: COG1142; oxidoreductase, Fe-S subunit 3197667 ygfS 3668992 ygfS Shigella sonnei Ss046 oxidoreductase, Fe-S subunit YP_311863.1 3197176 R 300269 CDS YP_311864.1 74313445 3668993 complement(3197664..3199598) 1 NC_007384.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit 3199598 ygfT 3668993 ygfT Shigella sonnei Ss046 oxidoreductase Fe-S binding subunit YP_311864.1 3197664 R 300269 CDS YP_311865.1 74313446 3668994 complement(3199622..3200653) 1 NC_007384.1 Code: L; COG: COG3335; IS630 orf 3200653 3668994 SSON_3040 Shigella sonnei Ss046 IS630 orf YP_311865.1 3199622 R 300269 CDS YP_311866.1 74313447 3668995 3201105..3202622 1 NC_007384.1 Code: F; COG: COG2233; permease 3202622 ygfU 3668995 ygfU Shigella sonnei Ss046 permease YP_311866.1 3201105 D 300269 CDS YP_311867.1 74313448 3668996 3202872..3203420 1 NC_007384.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 3203420 3668996 SSON_3042 Shigella sonnei Ss046 isopentenyl-diphosphate delta-isomerase YP_311867.1 3202872 D 300269 CDS YP_311868.1 74313449 3668997 complement(3203463..3204980) 1 NC_007384.1 suppressor of ColE1 mutation in primer RNA; class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 3204980 lysS 3668997 lysS Shigella sonnei Ss046 lysyl-tRNA synthetase YP_311868.1 3203463 R 300269 CDS YP_311869.1 74313450 3668999 complement(3206179..3207912) 1 NC_007384.1 5' --> 3' specific; 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ 3207912 recJ 3668999 recJ Shigella sonnei Ss046 ssDNA exonuclease RecJ YP_311869.1 3206179 R 300269 CDS YP_311870.1 74313451 3669000 complement(3207918..3208628) 1 NC_007384.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC 3208628 dsbC 3669000 dsbC Shigella sonnei Ss046 thiol:disulfide interchange protein DsbC YP_311870.1 3207918 R 300269 CDS YP_311871.1 74313452 3669001 complement(3208653..3209549) 1 NC_007384.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 3209549 xerD 3669001 xerD Shigella sonnei Ss046 site-specific tyrosine recombinase XerD YP_311871.1 3208653 R 300269 CDS YP_311872.1 74313453 3669163 3209661..3210182 1 NC_007384.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 3210182 fldB 3669163 fldB Shigella sonnei Ss046 flavodoxin FldB YP_311872.1 3209661 D 300269 CDS YP_311873.1 74313454 3669164 complement(3210222..3210629) 1 NC_007384.1 hypothetical protein 3210629 3669164 SSON_3049 Shigella sonnei Ss046 hypothetical protein YP_311873.1 3210222 R 300269 CDS YP_311874.1 74313455 3669165 complement(3210610..3210876) 1 NC_007384.1 Code: S; COG: COG2938; hypothetical protein 3210876 ygfY 3669165 ygfY Shigella sonnei Ss046 hypothetical protein YP_311874.1 3210610 R 300269 CDS YP_311875.1 74313456 3669166 3211119..3212099 1 NC_007384.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; global regulator 3212099 ygfZ 3669166 ygfZ Shigella sonnei Ss046 global regulator YP_311875.1 3211119 D 300269 CDS YP_311876.1 74313457 3669167 complement(3212295..3212954) 1 NC_007384.1 Code: R; COG: COG1272; oxidoreductase 3212954 3669167 SSON_3052 Shigella sonnei Ss046 oxidoreductase YP_311876.1 3212295 R 300269 CDS YP_311877.1 74313458 3669168 complement(3213118..3213429) 1 NC_007384.1 Code: S; COG: COG3097; hypothetical protein 3213429 yqfB 3669168 yqfB Shigella sonnei Ss046 hypothetical protein YP_311877.1 3213118 R 300269 CDS YP_311878.1 74313459 3669169 3213468..3214907 1 NC_007384.1 Code: G; COG: COG2723; 6-phospho-beta-glucosidase 3214907 bglA 3669169 bglA Shigella sonnei Ss046 6-phospho-beta-glucosidase YP_311878.1 3213468 D 300269 CDS YP_311879.1 74313460 3669170 complement(3214964..3215707) 1 NC_007384.1 Code: IQR; COG: COG1028; hypothetical protein 3215707 ygfF 3669170 ygfF Shigella sonnei Ss046 hypothetical protein YP_311879.1 3214964 R 300269 CDS YP_311880.1 74313461 3669171 complement(3215973..3218846) 1 NC_007384.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 3218846 gcvP 3669171 gcvP Shigella sonnei Ss046 glycine dehydrogenase YP_311880.1 3215973 R 300269 CDS YP_311881.1 74313462 3669172 complement(3218965..3219354) 1 NC_007384.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 3219354 gcvH 3669172 gcvH Shigella sonnei Ss046 glycine cleavage system protein H YP_311881.1 3218965 R 300269 CDS YP_311882.1 74313463 3669173 complement(3219378..3220472) 1 NC_007384.1 T protein; tetrahydrofolate-dependent; catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 3220472 gcvT 3669173 gcvT Shigella sonnei Ss046 glycine cleavage system aminomethyltransferase T YP_311882.1 3219378 R 300269 CDS YP_311883.1 74313464 3669174 complement(3220919..3222121) 1 NC_007384.1 Code: HC; COG: COG0654; hypothetical protein 3222121 visC 3669174 visC Shigella sonnei Ss046 hypothetical protein YP_311883.1 3220919 R 300269 CDS YP_311884.1 74313465 3669175 complement(3222144..3223322) 1 NC_007384.1 2-octaprenyl-6-methoxyphenol--> 2-octaprenyl-6-methoxy-1, 4-benzoquinone; Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase 3223322 ubiH 3669175 ubiH Shigella sonnei Ss046 2-octaprenyl-6-methoxyphenyl hydroxylase YP_311884.1 3222144 R 300269 CDS YP_311885.1 74313466 3669176 complement(3223319..3224644) 1 NC_007384.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II 3224644 pepP 3669176 pepP Shigella sonnei Ss046 proline aminopeptidase P II YP_311885.1 3223319 R 300269 CDS YP_311886.2 161986458 3669177 complement(3224670..3225248) 1 NC_007384.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein 3225248 ygfB 3669177 ygfB Shigella sonnei Ss046 hypothetical protein YP_311886.2 3224670 R 300269 CDS YP_311887.1 74313468 3669178 3225416..3225745 1 NC_007384.1 Code: S; COG: COG3027; Z-ring-associated protein 3225745 ygfE 3669178 ygfE Shigella sonnei Ss046 Z-ring-associated protein YP_311887.1 3225416 D 300269 CDS YP_311888.1 74313469 3669179 3226045..3226593 1 NC_007384.1 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function; ligase 3226593 ygfA 3669179 ygfA Shigella sonnei Ss046 ligase YP_311888.1 3226045 D 300269 CDS YP_311889.1 74313470 3669180 complement(3227372..3228604) 1 NC_007384.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 3228604 serA 3669180 serA Shigella sonnei Ss046 D-3-phosphoglycerate dehydrogenase YP_311889.1 3227372 R 300269 CDS YP_311890.1 74313471 3669181 complement(3228860..3229519) 1 NC_007384.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 3229519 rpiA 3669181 rpiA Shigella sonnei Ss046 ribose-5-phosphate isomerase A YP_311890.1 3228860 R 300269 CDS YP_311891.1 74313472 3669202 3229949..3230842 1 NC_007384.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 3230842 iciA 3669202 iciA Shigella sonnei Ss046 chromosome replication initiation inhibitor protein YP_311891.1 3229949 D 300269 CDS YP_311892.1 74313473 3669203 3231045..3233189 1 NC_007384.1 MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 3233189 sbm 3669203 sbm Shigella sonnei Ss046 methylmalonyl-CoA mutase YP_311892.1 3231045 D 300269 CDS YP_311893.1 74313474 3669204 3233182..3234177 1 NC_007384.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 3234177 ygfD 3669204 ygfD Shigella sonnei Ss046 arginine/ornithine transport system ATPase YP_311893.1 3233182 D 300269 CDS YP_311894.2 161986457 3669205 3234188..3234973 1 NC_007384.1 catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA; methylmalonyl-CoA decarboxylase 3234973 ygfG 3669205 ygfG Shigella sonnei Ss046 methylmalonyl-CoA decarboxylase YP_311894.2 3234188 D 300269 CDS YP_311895.1 74313476 3669206 3234997..3236475 1 NC_007384.1 Code: C; COG: COG0427; coenzyme A transferase 3236475 ygfH 3669206 ygfH Shigella sonnei Ss046 coenzyme A transferase YP_311895.1 3234997 D 300269 CDS YP_311896.1 74313477 3669207 complement(3237106..3237609) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3237609 3669207 SSON_3072 Shigella sonnei Ss046 IS1 ORF YP_311896.1 3237106 R 300269 CDS YP_311897.1 74313478 3669209 complement(3238311..3239051) 1 NC_007384.1 Code: S; COG: COG2968; hypothetical protein 3239051 yggE 3669209 yggE Shigella sonnei Ss046 hypothetical protein YP_311897.1 3238311 R 300269 CDS YP_311898.1 74313479 3669210 complement(3239144..3239779) 1 NC_007384.1 Involved in the export of arginine; arginine exporter protein 3239779 yggA 3669210 yggA Shigella sonnei Ss046 arginine exporter protein YP_311898.1 3239144 R 300269 CDS YP_311899.1 74313480 3669211 complement(3239918..3240778) 1 NC_007384.1 participates in the regulation of osmotic pressure changes within the cel; mechanosensitive ion channel protein MscS 3240778 yggB 3669211 yggB Shigella sonnei Ss046 mechanosensitive ion channel protein MscS YP_311899.1 3239918 R 300269 CDS YP_311900.1 74313481 3669212 complement(3241136..3242215) 1 NC_007384.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 3242215 fba 3669212 fba Shigella sonnei Ss046 fructose-bisphosphate aldolase YP_311900.1 3241136 R 300269 CDS YP_311901.1 74313482 3669213 complement(3242430..3243593) 1 NC_007384.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 3243593 pgk 3669213 pgk Shigella sonnei Ss046 phosphoglycerate kinase YP_311901.1 3242430 R 300269 CDS YP_311902.1 74313483 3669214 complement(3243643..3244662) 1 NC_007384.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase 3244662 epd 3669214 epd Shigella sonnei Ss046 erythrose 4-phosphate dehydrogenase YP_311902.1 3243643 R 300269 CDS YP_311903.1 74313484 3669215 3245034..3245465 1 NC_007384.1 Code: R; COG: COG1661; hypothetical protein 3245465 3669215 SSON_3080 Shigella sonnei Ss046 hypothetical protein YP_311903.1 3245034 D 300269 CDS YP_311904.1 74313485 3669216 3245488..3246066 1 NC_007384.1 inner membrane protein 3246066 3669216 SSON_3081 Shigella sonnei Ss046 inner membrane protein YP_311904.1 3245488 D 300269 CDS YP_311905.1 74313486 3669217 3246067..3246774 1 NC_007384.1 Code: P; COG: COG0619; hypothetical protein 3246774 3669217 SSON_3082 Shigella sonnei Ss046 hypothetical protein YP_311905.1 3246067 D 300269 CDS YP_311906.1 74313487 3669218 3246762..3247439 1 NC_007384.1 Code: P; COG: COG1122; ABC transporter ATP-binding protein 3247439 3669218 SSON_3083 Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_311906.1 3246762 D 300269 CDS YP_311907.1 74313488 3669219 3247433..3248110 1 NC_007384.1 Code: P; COG: COG1118; ABC transporter ATP-binding protein 3248110 3669219 SSON_3084 Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_311907.1 3247433 D 300269 CDS YP_311908.1 74313489 3669220 complement(3248082..3248795) 1 NC_007384.1 Code: H; COG: COG1072; fructose transport system kinase 3248795 frcK 3669220 frcK Shigella sonnei Ss046 fructose transport system kinase YP_311908.1 3248082 R 300269 CDS YP_311909.1 74313490 3669221 3249120..3249626 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3249626 3669221 SSON_3086 Shigella sonnei Ss046 IS1 ORF YP_311909.1 3249120 D 300269 CDS YP_311910.1 74313491 3667333 complement(3250661..3251104) 1 NC_007384.1 TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein; mannitol phosphotransferase subunit EIIA 3251104 cmtB 3667333 cmtB Shigella sonnei Ss046 mannitol phosphotransferase subunit EIIA YP_311910.1 3250661 R 300269 CDS YP_311911.1 74313492 3667334 complement(3251418..3253409) 1 NC_007384.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 3253409 tktA 3667334 tktA Shigella sonnei Ss046 transketolase YP_311911.1 3251418 R 300269 CDS YP_311912.1 74313493 3667335 3253561..3254445 1 NC_007384.1 Code: O; COG: COG0501; hypothetical protein 3254445 yggG 3667335 yggG Shigella sonnei Ss046 hypothetical protein YP_311912.1 3253561 D 300269 CDS YP_311913.1 74313494 3667336 complement(3254588..3255508) 1 NC_007384.1 catalyzes the formation of putrescine from agmatine; agmatinase 3255508 speB 3667336 speB Shigella sonnei Ss046 agmatinase YP_311913.1 3254588 R 300269 CDS YP_311914.1 74313495 3667337 complement(3255646..3257622) 1 NC_007384.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase 3257622 speA 3667337 speA Shigella sonnei Ss046 arginine decarboxylase YP_311914.1 3255646 R 300269 CDS YP_311915.1 74313496 3667338 complement(3257631..3257777) 1 NC_007384.1 hypothetical protein 3257777 yqgB 3667338 yqgB Shigella sonnei Ss046 hypothetical protein YP_311915.1 3257631 R 300269 CDS YP_311916.1 74313497 3667339 3257898..3258113 1 NC_007384.1 hypothetical protein 3258113 yqgC 3667339 yqgC Shigella sonnei Ss046 hypothetical protein YP_311916.1 3257898 D 300269 CDS YP_311917.1 74313498 3667340 complement(3258110..3258361) 1 NC_007384.1 hypothetical protein 3258361 yqgD 3667340 yqgD Shigella sonnei Ss046 hypothetical protein YP_311917.1 3258110 R 300269 CDS YP_311918.1 74313499 3667341 3258417..3259571 1 NC_007384.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3259571 metK 3667341 metK Shigella sonnei Ss046 S-adenosylmethionine synthetase YP_311918.1 3258417 D 300269 CDS YP_311919.1 74313500 3667342 3260007..3261401 1 NC_007384.1 Code: GEPR; COG: COG0477; galactose-proton symport of transport system 3261401 galP 3667342 galP Shigella sonnei Ss046 galactose-proton symport of transport system YP_311919.1 3260007 D 300269 CDS YP_311920.1 74313501 3667343 3261478..3261975 1 NC_007384.1 Code: S; COG: COG3091; hypothetical protein 3261975 sprT 3667343 sprT Shigella sonnei Ss046 hypothetical protein YP_311920.1 3261478 D 300269 CDS YP_311921.1 74313502 3667344 3262070..3262777 1 NC_007384.1 Code: L; COG: COG2356; DNA-specific endonuclease I 3262777 endA 3667344 endA Shigella sonnei Ss046 DNA-specific endonuclease I YP_311921.1 3262070 D 300269 CDS YP_311922.2 161986456 3667345 3262857..3263591 1 NC_007384.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3263591 yggJ 3667345 yggJ Shigella sonnei Ss046 16S ribosomal RNA methyltransferase RsmE YP_311922.2 3262857 D 300269 CDS YP_311923.1 74313504 3667346 3263604..3264554 1 NC_007384.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3264554 gshB 3667346 gshB Shigella sonnei Ss046 glutathione synthetase YP_311923.1 3263604 D 300269 CDS YP_311924.2 161986455 3667347 3264663..3265226 1 NC_007384.1 Code: K; COG: COG1678; hypothetical protein 3265226 yqgE 3667347 yqgE Shigella sonnei Ss046 hypothetical protein YP_311924.2 3264663 D 300269 CDS YP_311925.1 74313506 3667348 3265226..3265642 1 NC_007384.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3265642 yqgF 3667348 yqgF Shigella sonnei Ss046 Holliday junction resolvase-like protein YP_311925.1 3265226 D 300269 CDS YP_311926.1 74313508 3667350 complement(3265817..3266842) 1 NC_007384.1 Code: NU; COG: COG2805; protein transport 3266842 yggR 3667350 yggR Shigella sonnei Ss046 protein transport YP_311926.1 3265817 R 300269 CDS YP_311927.1 74313507 3667349 3266815..3267519 1 NC_007384.1 Code: R; COG: COG0325; hypothetical protein 3267519 yggS 3667349 yggS Shigella sonnei Ss046 hypothetical protein YP_311927.1 3266815 D 300269 CDS YP_311928.1 74313509 3669438 3267537..3268103 1 NC_007384.1 Code: S; COG: COG0762; resistance protein 3268103 yggT 3669438 yggT Shigella sonnei Ss046 resistance protein YP_311928.1 3267537 D 300269 CDS YP_311929.2 161986454 3669439 3268100..3268390 1 NC_007384.1 Code: S; COG: COG1872; hypothetical protein 3268390 yggU 3669439 yggU Shigella sonnei Ss046 hypothetical protein YP_311929.2 3268100 D 300269 CDS YP_311930.1 74313511 3669440 3268398..3268991 1 NC_007384.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 3268991 yggV 3669440 yggV Shigella sonnei Ss046 deoxyribonucleotide triphosphate pyrophosphatase YP_311930.1 3268398 D 300269 CDS YP_311931.1 74313512 3669441 3268984..3270120 1 NC_007384.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3270120 yggW 3669441 yggW Shigella sonnei Ss046 coproporphyrinogen III oxidase YP_311931.1 3268984 D 300269 CDS YP_311932.1 74313513 3669442 3270431..3270661 1 NC_007384.1 hypothetical protein 3270661 3669442 SSON_3110 Shigella sonnei Ss046 hypothetical protein YP_311932.1 3270431 D 300269 CDS YP_311933.1 74313514 3669443 3270665..3271417 1 NC_007384.1 Code: G; COG: COG1638; dicarboxylate-binding periplasmic protein 3271417 3669443 SSON_3111 Shigella sonnei Ss046 dicarboxylate-binding periplasmic protein YP_311933.1 3270665 D 300269 CDS YP_311934.1 74313515 3669444 3271900..3272403 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3272403 3669444 SSON_3112 Shigella sonnei Ss046 IS1 ORF YP_311934.1 3271900 D 300269 CDS YP_311935.1 74313516 3669446 complement(3273131..3274162) 1 NC_007384.1 Code: L; COG: COG3335; IS630 orf 3274162 3669446 SSON_3114 Shigella sonnei Ss046 IS630 orf YP_311935.1 3273131 R 300269 CDS YP_311936.1 74313517 3669448 3275006..3275509 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3275509 3669448 SSON_3116 Shigella sonnei Ss046 IS1 ORF YP_311936.1 3275006 D 300269 CDS YP_311937.1 74313518 3669449 complement(3275566..3276531) 1 NC_007384.1 Code: P; COG: COG0861; transporter 3276531 ygjT 3669449 ygjT Shigella sonnei Ss046 transporter YP_311937.1 3275566 R 300269 CDS YP_311938.1 74313519 3669450 complement(3276814..3277818) 1 NC_007384.1 Code: R; COG: COG0673; hypothetical protein 3277818 ygjR 3669450 ygjR Shigella sonnei Ss046 hypothetical protein YP_311938.1 3276814 R 300269 CDS YP_311939.1 74313520 3669451 complement(3277879..3278454) 1 NC_007384.1 Code: S; COG: COG2949; hypothetical protein 3278454 ygjQ 3669451 ygjQ Shigella sonnei Ss046 hypothetical protein YP_311939.1 3277879 R 300269 CDS YP_311940.1 74313521 3669452 complement(3278639..3279178) 1 NC_007384.1 Code: R; COG: COG1451; hypothetical protein 3279178 ygjP 3669452 ygjP Shigella sonnei Ss046 hypothetical protein YP_311940.1 3278639 R 300269 CDS YP_311941.1 74313522 3669453 3279227..3280363 1 NC_007384.1 Code: J; COG: COG2813; hypothetical protein 3280363 ygjO 3669453 ygjO Shigella sonnei Ss046 hypothetical protein YP_311941.1 3279227 D 300269 CDS YP_311942.1 74313523 3669454 3280648..3280962 1 NC_007384.1 Code: S; COG: COG4680; hypothetical protein 3280962 ygjN 3669454 ygjN Shigella sonnei Ss046 hypothetical protein YP_311942.1 3280648 D 300269 CDS YP_311943.1 74313524 3669455 3280959..3281375 1 NC_007384.1 Code: K; COG: COG5499; hypothetical protein 3281375 ygjM 3669455 ygjM Shigella sonnei Ss046 hypothetical protein YP_311943.1 3280959 D 300269 CDS YP_311944.1 74313525 3669456 complement(3281420..3283438) 1 NC_007384.1 Code: C; COG: COG1902; NADPH dehydrogenase 3283438 ygjL 3669456 ygjL Shigella sonnei Ss046 NADPH dehydrogenase YP_311944.1 3281420 R 300269 CDS YP_311945.1 74313526 3669457 complement(3283664..3286015) 1 NC_007384.1 glycosyl hydrolase 3286015 ygjK 3669457 ygjK Shigella sonnei Ss046 glycosyl hydrolase YP_311945.1 3283664 R 300269 CDS YP_311946.1 74313527 3669419 complement(3286032..3286925) 1 NC_007384.1 hypothetical protein 3286925 ygjJ 3669419 ygjJ Shigella sonnei Ss046 hypothetical protein YP_311946.1 3286032 R 300269 CDS YP_311947.1 74313528 3669420 complement(3287585..3288088) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3288088 3669420 SSON_3127 Shigella sonnei Ss046 IS1 ORF YP_311947.1 3287585 R 300269 CDS YP_311948.1 74313529 3669422 complement(3288749..3289252) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3289252 3669422 SSON_3129 Shigella sonnei Ss046 IS1 ORF YP_311948.1 3288749 R 300269 CDS YP_311949.1 74313531 3669424 complement(3289666..3290697) 1 NC_007384.1 Code: L; COG: COG3335; IS630 orf 3290697 3669424 SSON_3131 Shigella sonnei Ss046 IS630 orf YP_311949.1 3289666 R 300269 CDS YP_311950.1 74313530 3669423 3290584..3291258 1 NC_007384.1 hypothetical protein 3291258 yghT 3669423 yghT Shigella sonnei Ss046 hypothetical protein YP_311950.1 3290584 D 300269 CDS YP_311951.1 74313532 3669425 complement(3291307..3292806) 1 NC_007384.1 Code: P; COG: COG0306; low-affinity phosphate transport protein 3292806 pitB 3669425 pitB Shigella sonnei Ss046 low-affinity phosphate transport protein YP_311951.1 3291307 R 300269 CDS YP_311952.1 74313533 3669426 complement(3293098..3294957) 1 NC_007384.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase 3294957 gsp 3669426 gsp Shigella sonnei Ss046 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase YP_311952.1 3293098 R 300269 CDS YP_311953.1 74313534 3669427 3295114..3296028 1 NC_007384.1 YghU; B2989; one of eight glutathione transferase proteins from E. coli; glutathione S-transferase 3296028 3669427 SSON_3134 Shigella sonnei Ss046 glutathione S-transferase YP_311953.1 3295114 D 300269 CDS YP_311954.1 74313535 3669428 complement(3296151..3296399) 1 NC_007384.1 Code: O; COG: COG0298; hydrogenase 2 accessory protein HypG 3296399 hybG 3669428 hybG Shigella sonnei Ss046 hydrogenase 2 accessory protein HypG YP_311954.1 3296151 R 300269 CDS YP_311955.1 74313536 3669429 complement(3296412..3296753) 1 NC_007384.1 may modulate levels of hydrogenease-2; plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF 3296753 hybF 3669429 hybF Shigella sonnei Ss046 hydrogenase nickel incorporation protein HybF YP_311955.1 3296412 R 300269 CDS YP_311956.1 74313537 3669430 complement(3296746..3297234) 1 NC_007384.1 hydrogenase 2-specific chaperone 3297234 hybE 3669430 hybE Shigella sonnei Ss046 hydrogenase 2-specific chaperone YP_311956.1 3296746 R 300269 CDS YP_311957.1 74313538 3669431 complement(3297227..3297721) 1 NC_007384.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase 3297721 hybD 3669431 hybD Shigella sonnei Ss046 hydrogenase 2 maturation endopeptidase YP_311957.1 3297227 R 300269 CDS YP_311958.1 74313539 3669432 complement(3297721..3299424) 1 NC_007384.1 involved in hydrogen uptake; hydrogenase 2 large subunit 3299424 hybC 3669432 hybC Shigella sonnei Ss046 hydrogenase 2 large subunit YP_311958.1 3297721 R 300269 CDS YP_311959.1 74313540 3669433 complement(3299421..3300599) 1 NC_007384.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; hydrogenase 2 b cytochrome subunit 3300599 hybB 3669433 hybB Shigella sonnei Ss046 hydrogenase 2 b cytochrome subunit YP_311959.1 3299421 R 300269 CDS YP_311960.1 74313541 3669434 complement(3300589..3301575) 1 NC_007384.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA 3301575 hybA 3669434 hybA Shigella sonnei Ss046 hydrogenase 2 protein HybA YP_311960.1 3300589 R 300269 CDS YP_311961.1 74313542 3669435 complement(3301578..3302696) 1 NC_007384.1 involved in hydrogen uptake; hydrogenase 2 small subunit 3302696 3669435 SSON_3142 Shigella sonnei Ss046 hydrogenase 2 small subunit YP_311961.1 3301578 R 300269 CDS YP_311962.1 74313543 3669436 complement(3302885..3303172) 1 NC_007384.1 hypothetical protein 3303172 3669436 SSON_3143 Shigella sonnei Ss046 hypothetical protein YP_311962.1 3302885 R 300269 CDS YP_311963.1 74313544 3669437 complement(3303291..3304217) 1 NC_007384.1 Code: Q; COG: COG0412; hydrolase 3304217 yghYX 3669437 yghYX Shigella sonnei Ss046 hydrolase YP_311963.1 3303291 R 300269 CDS YP_311964.1 74313545 3669379 3304335..3305375 1 NC_007384.1 Code: C; COG: COG0667; aldo/keto reductase 3305375 3669379 SSON_3145 Shigella sonnei Ss046 aldo/keto reductase YP_311964.1 3304335 D 300269 CDS YP_311965.1 74313546 3669380 complement(3305415..3305909) 1 NC_007384.1 Code: S; COG: COG2862; hypothetical protein 3305909 yqhA 3669380 yqhA Shigella sonnei Ss046 hypothetical protein YP_311965.1 3305415 R 300269 CDS YP_311966.1 74313547 3669381 3306100..3306984 1 NC_007384.1 Code: IQR; COG: COG1028; oxidoreductase 3306984 yghA 3669381 yghA Shigella sonnei Ss046 oxidoreductase YP_311966.1 3306100 D 300269 CDS YP_311967.1 74313548 3669382 complement(3307144..3307569) 1 NC_007384.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD 3307569 exbD 3669382 exbD Shigella sonnei Ss046 biopolymer transport protein ExbD YP_311967.1 3307144 R 300269 CDS YP_311968.1 74313549 3669383 complement(3307576..3308310) 1 NC_007384.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB 3308310 exbB 3669383 exbB Shigella sonnei Ss046 biopolymer transport protein ExbB YP_311968.1 3307576 R 300269 CDS YP_311969.1 74313550 3669384 complement(3308303..3308458) 1 NC_007384.1 hypothetical protein 3308458 3669384 SSON_3150 Shigella sonnei Ss046 hypothetical protein YP_311969.1 3308303 R 300269 CDS YP_311970.1 74313551 3669385 3308562..3309749 1 NC_007384.1 beta-cystathionase; catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3309749 metC 3669385 metC Shigella sonnei Ss046 cystathionine beta-lyase YP_311970.1 3308562 D 300269 CDS YP_311971.1 74313552 3669386 3309889..3310548 1 NC_007384.1 Code: S; COG: COG0586; hypothetical protein 3310548 yghB 3669386 yghB Shigella sonnei Ss046 hypothetical protein YP_311971.1 3309889 D 300269 CDS YP_311972.1 74313554 3669388 complement(3310588..3311715) 1 NC_007384.1 Code: K; COG: COG2207; AraC family transcriptional regulator 3311715 yqhC 3669388 yqhC Shigella sonnei Ss046 AraC family transcriptional regulator YP_311972.1 3310588 R 300269 CDS YP_311973.1 74313553 3669387 3311681..3312844 1 NC_007384.1 Code: C; COG: COG1979; oxidoreductase 3312844 yqhD 3669387 yqhD Shigella sonnei Ss046 oxidoreductase YP_311973.1 3311681 D 300269 CDS YP_311974.2 161986453 3669389 3312949..3313776 1 NC_007384.1 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3313776 dkgA 3669389 dkgA Shigella sonnei Ss046 2,5-diketo-D-gluconate reductase A YP_311974.2 3312949 D 300269 CDS YP_311975.1 74313556 3669390 3313977..3314903 1 NC_007384.1 hypothetical protein 3314903 yqhG 3669390 yqhG Shigella sonnei Ss046 hypothetical protein YP_311975.1 3313977 D 300269 CDS YP_311976.1 74313557 3669391 3314954..3315211 1 NC_007384.1 Code: M; COG: COG4238; outer membrane lipoprotein 3315211 yqhH 3669391 yqhH Shigella sonnei Ss046 outer membrane lipoprotein YP_311976.1 3314954 D 300269 CDS YP_311977.1 74313558 3669392 complement(3315254..3317473) 1 NC_007384.1 Code: C; COG: COG1032; hypothetical protein 3317473 ygiRQ 3669392 ygiRQ Shigella sonnei Ss046 hypothetical protein YP_311977.1 3315254 R 300269 CDS YP_311978.1 74313559 3669393 complement(3317584..3318996) 1 NC_007384.1 Code: Q; COG: COG2132; repressor protein for FtsI 3318996 sufI 3669393 sufI Shigella sonnei Ss046 repressor protein for FtsI YP_311978.1 3317584 R 300269 CDS YP_311979.1 74313560 3669394 complement(3319071..3319808) 1 NC_007384.1 Code: I; COG: COG0204; 1-acyl-sn-glycerol-3-phosphate acyltransferase 3319808 plsC 3669394 plsC Shigella sonnei Ss046 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_311979.1 3319071 R 300269 CDS YP_311980.1 74313561 3669395 complement(3320041..3322299) 1 NC_007384.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 3322299 parC 3669395 parC Shigella sonnei Ss046 DNA topoisomerase IV subunit A YP_311980.1 3320041 R 300269 CDS YP_311981.1 74313562 3669396 complement(3322845..3323327) 1 NC_007384.1 Code: L; COG: COG3449; hypothetical protein 3323327 3669396 SSON_3162 Shigella sonnei Ss046 hypothetical protein YP_311981.1 3322845 R 300269 CDS YP_311982.1 74313563 3669397 complement(3323380..3323772) 1 NC_007384.1 Code: S; COG: COG3111; hypothetical protein 3323772 ygiW 3669397 ygiW Shigella sonnei Ss046 hypothetical protein YP_311982.1 3323380 R 300269 CDS YP_311983.1 74313564 3669398 3323924..3324583 1 NC_007384.1 similar to quorum sensing Escherichia coli regulator B; response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3324583 qseB 3669398 qseB Shigella sonnei Ss046 DNA-binding transcriptional regulator QseB YP_311983.1 3323924 D 300269 CDS YP_311984.1 74313565 3669360 3324580..3325929 1 NC_007384.1 similar to quorum sensing Escherichia coli regulator C; Code: T; COG: COG0642; sensor protein QseC 3325929 qseC 3669360 qseC Shigella sonnei Ss046 sensor protein QseC YP_311984.1 3324580 D 300269 CDS YP_311985.1 74313566 3669361 3326039..3326620 1 NC_007384.1 Code: R; COG: COG2249; modulator of drug activity B 3326620 mdaB 3669361 mdaB Shigella sonnei Ss046 modulator of drug activity B YP_311985.1 3326039 D 300269 CDS YP_311986.1 74313567 3669362 3326651..3326965 1 NC_007384.1 Code: S; COG: COG1359; hypothetical protein 3326965 ygiN 3669362 ygiN Shigella sonnei Ss046 hypothetical protein YP_311986.1 3326651 D 300269 CDS YP_311987.1 74313568 3669363 complement(3327013..3328905) 1 NC_007384.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 3328905 parE 3669363 parE Shigella sonnei Ss046 DNA topoisomerase IV subunit B YP_311987.1 3327013 R 300269 CDS YP_311988.1 74313569 3669364 complement(3328934..3329515) 1 NC_007384.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase 3329515 yqiA 3669364 yqiA Shigella sonnei Ss046 esterase YP_311988.1 3328934 R 300269 CDS YP_311989.1 74313570 3669365 complement(3329515..3330342) 1 NC_007384.1 Code: R; COG: COG1409; cyclic 3',5'-adenosine monophosphate phosphodiesterase 3330342 icc 3669365 icc Shigella sonnei Ss046 cyclic 3',5'-adenosine monophosphate phosphodiesterase YP_311989.1 3329515 R 300269 CDS YP_311990.1 74313571 3669366 complement(3330367..3330789) 1 NC_007384.1 Code: S; COG: COG3151; hypothetical protein 3330789 yqiB 3669366 yqiB Shigella sonnei Ss046 hypothetical protein YP_311990.1 3330367 R 300269 CDS YP_311991.1 74313572 3669367 complement(3330790..3331419) 1 NC_007384.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase 3331419 nudF 3669367 nudF Shigella sonnei Ss046 ADP-ribose pyrophosphatase YP_311991.1 3330790 R 300269 CDS YP_311992.2 161986452 3669368 3331624..3333105 1 NC_007384.1 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes; trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3333105 tolC 3669368 tolC Shigella sonnei Ss046 outer membrane channel protein YP_311992.2 3331624 D 300269 CDS YP_311993.2 161986451 3669369 3333253..3333924 1 NC_007384.1 Code: S; COG: COG5463; hypothetical protein 3333924 ygiB 3669369 ygiB Shigella sonnei Ss046 hypothetical protein YP_311993.2 3333253 D 300269 CDS YP_311994.1 74313575 3669370 3333930..3335090 1 NC_007384.1 Code: E; COG: COG0754; synthetase/amidase 3335090 ygiC 3669370 ygiC Shigella sonnei Ss046 synthetase/amidase YP_311994.1 3333930 D 300269 CDS YP_311995.1 74313576 3669371 complement(3335128..3335943) 1 NC_007384.1 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein 3335943 ygiD 3669371 ygiD Shigella sonnei Ss046 hypothetical protein YP_311995.1 3335128 R 300269 CDS YP_311996.1 74313577 3669372 3336059..3336832 1 NC_007384.1 Code: P; COG: COG0428; zinc transporter ZupT 3336832 ygiE 3669372 ygiE Shigella sonnei Ss046 zinc transporter ZupT YP_311996.1 3336059 D 300269 CDS YP_311997.1 74313578 3669373 complement(3337321..3337974) 1 NC_007384.1 DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase 3337974 ribB 3669373 ribB Shigella sonnei Ss046 3,4-dihydroxy-2-butanone 4-phosphate synthase YP_311997.1 3337321 R 300269 CDS YP_311998.1 74313579 3669374 3338288..3338638 1 NC_007384.1 Code: S; COG: COG2960; hypothetical protein 3338638 3669374 SSON_3179 Shigella sonnei Ss046 hypothetical protein YP_311998.1 3338288 D 300269 CDS YP_311999.1 74313580 3669375 3338921..3339472 1 NC_007384.1 Code: NU; COG: COG3539; fimbrial protein 3339472 ygiL 3669375 ygiL Shigella sonnei Ss046 fimbrial protein YP_311999.1 3338921 D 300269 CDS YP_312000.2 161986450 3669377 complement(3340648..3341553) 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3341553 3669377 SSON_3182 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_312000.2 3340648 R 300269 CDS YP_312001.1 74313582 3669378 3342966..3343724 1 NC_007384.1 Code: NU; COG: COG3121; hypothetical protein 3343724 yqiH 3669378 yqiH Shigella sonnei Ss046 hypothetical protein YP_312001.1 3342966 D 300269 CDS YP_312002.1 74313583 3669340 3343726..3344790 1 NC_007384.1 hypothetical protein 3344790 yqiI 3669340 yqiI Shigella sonnei Ss046 hypothetical protein YP_312002.1 3343726 D 300269 CDS YP_312003.1 74313584 3669341 complement(3344810..3345841) 1 NC_007384.1 Code: L; COG: COG3335; IS630 orf 3345841 3669341 SSON_3185 Shigella sonnei Ss046 IS630 orf YP_312003.1 3344810 R 300269 CDS YP_312004.1 74313585 3669342 complement(3345988..3346188) 1 NC_007384.1 Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS 3346188 glgS 3669342 glgS Shigella sonnei Ss046 glycogen synthesis protein GlgS YP_312004.1 3345988 R 300269 CDS YP_312005.1 74313586 3669343 3346457..3347086 1 NC_007384.1 oxidoreductase 3347086 3669343 SSON_3187 Shigella sonnei Ss046 oxidoreductase YP_312005.1 3346457 D 300269 CDS YP_312006.1 74313587 3669344 3347113..3348774 1 NC_007384.1 Code: S; COG: COG2268; hypothetical protein 3348774 3669344 SSON_3188 Shigella sonnei Ss046 hypothetical protein YP_312006.1 3347113 D 300269 CDS YP_312007.1 74313588 3669345 complement(3349568..3351001) 1 NC_007384.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 3351001 3669345 SSON_3189 Shigella sonnei Ss046 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase YP_312007.1 3349568 R 300269 CDS YP_312008.1 74313589 3669346 complement(3351049..3353889) 1 NC_007384.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 3353889 glnE 3669346 glnE Shigella sonnei Ss046 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase YP_312008.1 3351049 R 300269 CDS YP_312009.1 74313590 3669347 complement(3353912..3355213) 1 NC_007384.1 Code: S; COG: COG3025; hypothetical protein 3355213 ygiF 3669347 ygiF Shigella sonnei Ss046 hypothetical protein YP_312009.1 3353912 R 300269 CDS YP_312010.1 74313591 3669348 3355455..3356075 1 NC_007384.1 Code: T; COG: COG3103; signal transduction protein 3356075 ygiM 3669348 ygiM Shigella sonnei Ss046 signal transduction protein YP_312010.1 3355455 D 300269 CDS YP_312011.1 74313592 3669349 3356139..3357377 1 NC_007384.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3357377 cca 3669349 cca Shigella sonnei Ss046 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase YP_312011.1 3356139 D 300269 CDS YP_312012.1 74313593 3669350 complement(3357540..3358361) 1 NC_007384.1 bacitracin resistance; BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 3358361 bacA 3669350 bacA Shigella sonnei Ss046 undecaprenyl pyrophosphate phosphatase YP_312012.1 3357540 R 300269 CDS YP_312013.1 74313594 3669351 complement(3358452..3358823) 1 NC_007384.1 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase 3358823 folB 3669351 folB Shigella sonnei Ss046 bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase YP_312013.1 3358452 R 300269 CDS YP_312014.1 74313595 3669352 3358925..3359542 1 NC_007384.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 3359542 ygiH 3669352 ygiH Shigella sonnei Ss046 glycerol-3-phosphate acyltransferase PlsY YP_312014.1 3358925 D 300269 CDS YP_312015.1 74313596 3669354 3360694..3361605 1 NC_007384.1 Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 3361605 ttdA 3669354 ttdA Shigella sonnei Ss046 tartrate dehydratase subunit alpha YP_312015.1 3360694 D 300269 CDS YP_312016.1 74313597 3669355 3361602..3362207 1 NC_007384.1 Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 3362207 ttdB 3669355 ttdB Shigella sonnei Ss046 L(+)-tartrate dehydratase subunit beta YP_312016.1 3361602 D 300269 CDS YP_312017.1 74313598 3669356 3362256..3363719 1 NC_007384.1 Code: P; COG: COG0471; hypothetical protein 3363719 ygjE 3669356 ygjE Shigella sonnei Ss046 hypothetical protein YP_312017.1 3362256 D 300269 CDS YP_312018.1 74313599 3669357 complement(3363762..3364775) 1 NC_007384.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 3364775 ygjD 3669357 ygjD Shigella sonnei Ss046 DNA-binding/iron metalloprotein/AP endonuclease YP_312018.1 3363762 R 300269 CDS YP_312019.1 74313600 3669358 3365012..3365227 1 NC_007384.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3365227 rpsU 3669358 rpsU Shigella sonnei Ss046 30S ribosomal protein S21 YP_312019.1 3365012 D 300269 CDS YP_312020.1 74313601 3669359 3365338..3367083 1 NC_007384.1 DNA biosynthesis; synthesizes RNA primers at the replication forks; DNA primase 3367083 dnaG 3669359 dnaG Shigella sonnei Ss046 DNA primase YP_312020.1 3365338 D 300269 CDS YP_312021.1 74313602 3669145 3367278..3369119 1 NC_007384.1 regulation of proteins induced at high temperatures; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3369119 rpoD 3669145 rpoD Shigella sonnei Ss046 RNA polymerase sigma factor RpoD YP_312021.1 3367278 D 300269 CDS YP_312022.1 74313603 3669146 complement(3369204..3370550) 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 3370550 3669146 SSON_3205 Shigella sonnei Ss046 IS4 orf YP_312022.1 3369204 R 300269 CDS YP_312023.1 74313604 3669147 complement(3370637..3371143) 1 NC_007384.1 Code: L; COG: COG3663; G/U mismatch-specific DNA glycosylase 3371143 ygjF 3669147 ygjF Shigella sonnei Ss046 G/U mismatch-specific DNA glycosylase YP_312023.1 3370637 R 300269 CDS YP_312024.1 74313605 3669149 complement(3371397..3372161) 1 NC_007384.1 Code: P; COG: COG2375; hypothetical protein 3372161 yqjH 3669149 yqjH Shigella sonnei Ss046 hypothetical protein YP_312024.1 3371397 R 300269 CDS YP_312025.1 74313606 3669150 3372449..3373072 1 NC_007384.1 Code: K; COG: COG1695; hypothetical protein 3373072 yqjI 3669150 yqjI Shigella sonnei Ss046 hypothetical protein YP_312025.1 3372449 D 300269 CDS YP_312026.1 74313607 3669151 complement(3373179..3374699) 1 NC_007384.1 Code: NT; COG: COG0840; aerotaxis sensor receptor, flavoprotein 3374699 aer 3669151 aer Shigella sonnei Ss046 aerotaxis sensor receptor, flavoprotein YP_312026.1 3373179 R 300269 CDS YP_312027.2 161986449 3669152 3375090..3376496 1 NC_007384.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 3376496 ygjG 3669152 ygjG Shigella sonnei Ss046 putrescine--2-oxoglutarate aminotransferase YP_312027.2 3375090 D 300269 CDS YP_312028.1 74313609 3669153 complement(3376538..3376870) 1 NC_007384.1 Code: R; COG: COG0073; hypothetical protein 3376870 ygjH 3669153 ygjH Shigella sonnei Ss046 hypothetical protein YP_312028.1 3376538 R 300269 CDS YP_312029.1 74313610 3669154 3377089..3378072 1 NC_007384.1 Code: K; COG: COG1609; DNA-binding transcriptional repressor EbgR 3378072 ebgR 3669154 ebgR Shigella sonnei Ss046 DNA-binding transcriptional repressor EbgR YP_312029.1 3377089 D 300269 CDS YP_312030.1 74313611 3669155 complement(3378132..3379478) 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 3379478 3669155 SSON_3214 Shigella sonnei Ss046 IS4 orf YP_312030.1 3378132 R 300269 CDS YP_312031.1 74313612 3669156 3379694..3382519 1 NC_007384.1 Code: G; COG: COG3250; evolved beta-D-galactosidase subunit alpha; cryptic gene 3382519 ebgA 3669156 ebgA Shigella sonnei Ss046 evolved beta-D-galactosidase subunit alpha; cryptic gene YP_312031.1 3379694 D 300269 CDS YP_312032.1 74313613 3669157 3382783..3383232 1 NC_007384.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 3383232 ebgC 3669157 ebgC Shigella sonnei Ss046 cryptic beta-D-galactosidase subunit beta YP_312032.1 3382783 D 300269 CDS YP_312033.1 74313614 3669158 3383295..3383882 1 NC_007384.1 hypothetical protein 3383882 3669158 SSON_3217 Shigella sonnei Ss046 hypothetical protein YP_312033.1 3383295 D 300269 CDS YP_312034.1 74313615 3669159 3383983..3385014 1 NC_007384.1 Code: L; COG: COG3335; IS630 orf 3385014 3669159 SSON_3218 Shigella sonnei Ss046 IS630 orf YP_312034.1 3383983 D 300269 CDS YP_312035.1 74313616 3669160 3385443..3386156 1 NC_007384.1 hypothetical protein 3386156 yghS 3669160 yghS Shigella sonnei Ss046 hypothetical protein YP_312035.1 3385443 D 300269 CDS YP_312036.1 74313617 3669161 3386188..3386946 1 NC_007384.1 hypothetical protein 3386946 yghR 3669161 yghR Shigella sonnei Ss046 hypothetical protein YP_312036.1 3386188 D 300269 CDS YP_312037.1 74313618 3669162 3386992..3388350 1 NC_007384.1 Code: R; COG: COG2244; hypothetical protein 3388350 yghQ 3669162 yghQ Shigella sonnei Ss046 hypothetical protein YP_312037.1 3386992 D 300269 CDS YP_312038.1 74313619 3667428 complement(3388344..3388847) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3388847 3667428 SSON_3222 Shigella sonnei Ss046 IS1 ORF YP_312038.1 3388344 R 300269 CDS YP_312039.1 74313620 3667429 complement(3389961..3393818) 1 NC_007384.1 serine protease 3393818 sigA 3667429 sigA Shigella sonnei Ss046 serine protease YP_312039.1 3389961 R 300269 CDS YP_312040.2 161986448 3667430 complement(3394179..3394940) 1 NC_007384.1 hypothetical protein 3394940 3667430 SSON_3224 Shigella sonnei Ss046 hypothetical protein YP_312040.2 3394179 R 300269 CDS YP_312041.1 74313622 3667431 complement(3396289..3399804) 1 NC_007384.1 Code: L; COG: COG1112; superfamily I DNA helicase 3399804 3667431 SSON_3225 Shigella sonnei Ss046 superfamily I DNA helicase YP_312041.1 3396289 R 300269 CDS YP_312042.1 74313623 3667432 complement(3400832..3401851) 1 NC_007384.1 Code: L; COG: COG3547; transposase 3401851 3667432 SSON_3226 Shigella sonnei Ss046 transposase YP_312042.1 3400832 R 300269 CDS YP_312043.1 74313624 3667435 complement(3403339..3404046) 1 NC_007384.1 Code: R; COG: COG1811; transporter 3404046 yqgA 3667435 yqgA Shigella sonnei Ss046 transporter YP_312043.1 3403339 R 300269 CDS YP_312044.1 74313625 3667436 3404364..3406394 1 NC_007384.1 Code: E; COG: COG1982; ornithine decarboxylase 3406394 speC 3667436 speC Shigella sonnei Ss046 ornithine decarboxylase YP_312044.1 3404364 D 300269 CDS YP_312045.1 74313626 3667437 complement(3406591..3407718) 1 NC_007384.1 Code: L; COG: COG3547; transposase 3407718 3667437 SSON_3231 Shigella sonnei Ss046 transposase YP_312045.1 3406591 R 300269 CDS YP_312046.1 74313627 3667438 complement(3408152..3409456) 1 NC_007384.1 Code: GEPR; COG: COG0477; transport of nucleosides, permease 3409456 nupG 3667438 nupG Shigella sonnei Ss046 transport of nucleosides, permease YP_312046.1 3408152 R 300269 CDS YP_312047.1 74313628 3667439 complement(3409610..3410692) 1 NC_007384.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3410692 mltC 3667439 mltC Shigella sonnei Ss046 murein transglycosylase C YP_312047.1 3409610 R 300269 CDS YP_312048.1 74313629 3667440 complement(3410754..3411029) 1 NC_007384.1 Code: CO; COG: COG2924; hypothetical protein 3411029 yggX 3667440 yggX Shigella sonnei Ss046 hypothetical protein YP_312048.1 3410754 R 300269 CDS YP_312049.1 74313630 3667441 complement(3411057..3412109) 1 NC_007384.1 G.C --> T.A transversions; Code: L; COG: COG1194; adenine DNA glycosylase 3412109 mutY 3667441 mutY Shigella sonnei Ss046 adenine DNA glycosylase YP_312049.1 3411057 R 300269 CDS YP_312050.1 74313631 3667442 3412270..3412989 1 NC_007384.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 3412989 trmB 3667442 trmB Shigella sonnei Ss046 tRNA (guanine-N(7)-)-methyltransferase YP_312050.1 3412270 D 300269 CDS YP_312051.2 161986447 3667443 3412989..3413315 1 NC_007384.1 Code: S; COG: COG3171; hypothetical protein 3413315 yggL 3667443 yggL Shigella sonnei Ss046 hypothetical protein YP_312051.2 3412989 D 300269 CDS YP_312052.1 74313633 3667444 3413499..3414218 1 NC_007384.1 hypothetical protein 3414218 yggN 3667444 yggN Shigella sonnei Ss046 hypothetical protein YP_312052.1 3413499 D 300269 CDS YP_312053.1 74313634 3667445 3414394..3415440 1 NC_007384.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II 3415440 ansB 3667445 ansB Shigella sonnei Ss046 L-asparaginase II YP_312053.1 3414394 D 300269 CDS YP_312054.1 74313635 3667486 3416259..3416762 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3416762 3667486 SSON_3241 Shigella sonnei Ss046 IS1 ORF YP_312054.1 3416259 D 300269 CDS YP_312055.1 74313636 3667487 3417361..3418605 1 NC_007384.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3418605 ygjU 3667487 ygjU Shigella sonnei Ss046 serine/threonine transporter SstT YP_312055.1 3417361 D 300269 CDS YP_312056.1 74313637 3667488 complement(3418610..3419161) 1 NC_007384.1 hypothetical protein 3419161 ygjV 3667488 ygjV Shigella sonnei Ss046 hypothetical protein YP_312056.1 3418610 R 300269 CDS YP_312057.1 74313638 3667489 complement(3419244..3420731) 1 NC_007384.1 Code: G; COG: COG2721; altronate hydrolase 3420731 uxaA 3667489 uxaA Shigella sonnei Ss046 altronate hydrolase YP_312057.1 3419244 R 300269 CDS YP_312058.1 74313639 3667490 complement(3420746..3422158) 1 NC_007384.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase 3422158 uxaC 3667490 uxaC Shigella sonnei Ss046 glucuronate isomerase YP_312058.1 3420746 R 300269 CDS YP_312059.1 74313640 3667492 complement(3424021..3425109) 1 NC_007384.1 minor pilin and initiator 3425109 3667492 SSON_3247 Shigella sonnei Ss046 minor pilin and initiator YP_312059.1 3424021 R 300269 CDS YP_312060.1 74313641 3667493 complement(3425106..3427808) 1 NC_007384.1 outer membrane fimbrial user protein 3427808 tsaC 3667493 tsaC Shigella sonnei Ss046 outer membrane fimbrial user protein YP_312060.1 3425106 R 300269 CDS YP_312061.1 74313642 3667494 complement(3428116..3429147) 1 NC_007384.1 Code: L; COG: COG3335; IS630 orf 3429147 3667494 SSON_3249 Shigella sonnei Ss046 IS630 orf YP_312061.1 3428116 R 300269 CDS YP_312062.1 74313643 3667495 complement(3429244..3429537) 1 NC_007384.1 adhesin major subunit pilin 3429537 3667495 SSON_3250 Shigella sonnei Ss046 adhesin major subunit pilin YP_312062.1 3429244 R 300269 CDS YP_312063.1 74313644 3667496 3430014..3430520 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3430520 3667496 SSON_3251 Shigella sonnei Ss046 IS1 ORF YP_312063.1 3430014 D 300269 CDS YP_312064.1 74313645 3667497 complement(3430455..3431063) 1 NC_007384.1 fimbrial protein 3431063 3667497 SSON_3252 Shigella sonnei Ss046 fimbrial protein YP_312064.1 3430455 R 300269 CDS YP_312065.1 74313646 3667498 3431359..3432135 1 NC_007384.1 regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 3432135 exuR 3667498 exuR Shigella sonnei Ss046 DNA-binding transcriptional repressor ExuR YP_312065.1 3431359 D 300269 CDS YP_312066.1 74313647 3667499 3432480..3433142 1 NC_007384.1 Code: S; COG: COG0586; hypothetical protein 3433142 yqjA 3667499 yqjA Shigella sonnei Ss046 hypothetical protein YP_312066.1 3432480 D 300269 CDS YP_312067.1 74313648 3667500 3433146..3433529 1 NC_007384.1 hypothetical protein 3433529 yqjB 3667500 yqjB Shigella sonnei Ss046 hypothetical protein YP_312067.1 3433146 D 300269 CDS YP_312068.1 74313649 3667501 3433661..3434044 1 NC_007384.1 hypothetical protein 3434044 yqjC 3667501 yqjC Shigella sonnei Ss046 hypothetical protein YP_312068.1 3433661 D 300269 CDS YP_312069.1 74313650 3667502 3434082..3434387 1 NC_007384.1 Code: S; COG: COG4575; hypothetical protein 3434387 yqjD 3667502 yqjD Shigella sonnei Ss046 hypothetical protein YP_312069.1 3434082 D 300269 CDS YP_312070.1 74313651 3667503 3434390..3434794 1 NC_007384.1 Code: S; COG: COG5393; hypothetical protein 3434794 yqjE 3667503 yqjE Shigella sonnei Ss046 hypothetical protein YP_312070.1 3434390 D 300269 CDS YP_312071.1 74313652 3667504 3434784..3435083 1 NC_007384.1 hypothetical protein 3435083 3667504 SSON_3259 Shigella sonnei Ss046 hypothetical protein YP_312071.1 3434784 D 300269 CDS YP_312072.1 74313653 3669002 3435179..3435661 1 NC_007384.1 Code: S; COG: COG2259; hypothetical protein 3435661 yqjF 3669002 yqjF Shigella sonnei Ss046 hypothetical protein YP_312072.1 3435179 D 300269 CDS YP_312073.1 74313654 3669003 3435731..3436744 1 NC_007384.1 Code: O; COG: COG0435; transferase 3436744 yqjG 3669003 yqjG Shigella sonnei Ss046 transferase YP_312073.1 3435731 D 300269 CDS YP_312074.1 74313655 3669004 3437009..3437374 1 NC_007384.1 Code: S; COG: COG3152; cytochrome 3437374 yhaH 3669004 yhaH Shigella sonnei Ss046 cytochrome YP_312074.1 3437009 D 300269 CDS YP_312075.1 74313656 3669005 3437616..3437972 1 NC_007384.1 Code: S; COG: COG3152; cytochrome 3437972 yhaI 3669005 yhaI Shigella sonnei Ss046 cytochrome YP_312075.1 3437616 D 300269 CDS YP_312076.1 74313657 3669007 3439024..3439725 1 NC_007384.1 Code: R; COG: COG1741; hypothetical protein 3439725 yhaK 3669007 yhaK Shigella sonnei Ss046 hypothetical protein YP_312076.1 3439024 D 300269 CDS YP_312077.1 74313658 3669008 3439742..3439912 1 NC_007384.1 hypothetical protein 3439912 yhaL 3669008 yhaL Shigella sonnei Ss046 hypothetical protein YP_312077.1 3439742 D 300269 CDS YP_312078.1 74313659 3669009 complement(3440046..3441356) 1 NC_007384.1 Code: S; COG: COG3681; hypothetical protein 3441356 yhaNM 3669009 yhaNM Shigella sonnei Ss046 hypothetical protein YP_312078.1 3440046 R 300269 CDS YP_312079.1 74313660 3669010 complement(3441384..3442715) 1 NC_007384.1 Code: E; COG: COG0814; transport system permease 3442715 yhaO 3669010 yhaO Shigella sonnei Ss046 transport system permease YP_312079.1 3441384 R 300269 CDS YP_312080.1 74313661 3669011 complement(3442990..3443817) 1 NC_007384.1 Code: E; COG: COG1760; L-serine dehydratase 3443817 yhaP 3669011 yhaP Shigella sonnei Ss046 L-serine dehydratase YP_312080.1 3442990 R 300269 CDS YP_312081.1 74313662 3669012 complement(3444426..3444878) 1 NC_007384.1 Code: J; COG: COG0251; hypothetical protein 3444878 yhaR 3669012 yhaR Shigella sonnei Ss046 hypothetical protein YP_312081.1 3444426 R 300269 CDS YP_312082.1 74313663 3669013 complement(3444829..3447123) 1 NC_007384.1 Code: C; COG: COG1882; formate acetyltransferase 3 3447123 tdcE 3669013 tdcE Shigella sonnei Ss046 formate acetyltransferase 3 YP_312082.1 3444829 R 300269 CDS YP_312083.1 74313664 3669014 complement(3447157..3448377) 1 NC_007384.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase 3448377 tdcD 3669014 tdcD Shigella sonnei Ss046 propionate/acetate kinase YP_312083.1 3447157 R 300269 CDS YP_312084.1 74313665 3669015 complement(3448391..3449722) 1 NC_007384.1 involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC 3449722 tdcC 3669015 tdcC Shigella sonnei Ss046 threonine/serine transporter TdcC YP_312084.1 3448391 R 300269 CDS YP_312085.1 74313666 3669016 complement(3449744..3450733) 1 NC_007384.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase 3450733 tdcB 3669016 tdcB Shigella sonnei Ss046 threonine dehydratase YP_312085.1 3449744 R 300269 CDS YP_312086.1 74313667 3669017 complement(3450832..3451770) 1 NC_007384.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA 3451770 tdcA 3669017 tdcA Shigella sonnei Ss046 DNA-binding transcriptional activator TdcA YP_312086.1 3450832 R 300269 CDS YP_312087.1 74313668 3669018 3451959..3452303 1 NC_007384.1 participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 3452303 tdcR 3669018 tdcR Shigella sonnei Ss046 DNA-binding transcriptional activator TdcR YP_312087.1 3451959 D 300269 CDS YP_312088.1 74313669 3669019 3452929..3453432 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3453432 3669019 SSON_3277 Shigella sonnei Ss046 IS1 ORF YP_312088.1 3452929 D 300269 CDS YP_312089.1 74313670 3669020 3454127..3454291 1 NC_007384.1 hypothetical protein 3454291 3669020 SSON_3278 Shigella sonnei Ss046 hypothetical protein YP_312089.1 3454127 D 300269 CDS YP_312090.2 161986446 3669021 complement(3455089..3456234) 1 NC_007384.1 Code: G; COG: COG1929; glycerate kinase 3456234 yhaD 3669021 yhaD Shigella sonnei Ss046 glycerate kinase YP_312090.2 3455089 R 300269 CDS YP_312091.2 161986445 3668963 complement(3456331..3457221) 1 NC_007384.1 catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase 3457221 garR 3668963 garR Shigella sonnei Ss046 tartronate semialdehyde reductase YP_312091.2 3456331 R 300269 CDS YP_312092.1 74313673 3668964 complement(3457251..3458021) 1 NC_007384.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase 3458021 yhaF 3668964 yhaF Shigella sonnei Ss046 alpha-dehydro-beta-deoxy-D-glucarate aldolase YP_312092.1 3457251 R 300269 CDS YP_312093.1 74313674 3668965 complement(3458037..3459371) 1 NC_007384.1 Code: GEPR; COG: COG0477; transporter 3459371 yhaU 3668965 yhaU Shigella sonnei Ss046 transporter YP_312093.1 3458037 R 300269 CDS YP_312094.1 74313675 3668966 3459746..3461317 1 NC_007384.1 Code: G; COG: COG2721; hydrolase 3461317 yhaG 3668966 yhaG Shigella sonnei Ss046 hydrolase YP_312094.1 3459746 D 300269 CDS YP_312095.1 74313676 3668967 3461635..3461937 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 3461937 3668967 SSON_3284 Shigella sonnei Ss046 IS600 ORF1 YP_312095.1 3461635 D 300269 CDS YP_312096.1 74313677 3668968 3462078..3462791 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 3462791 3668968 SSON_3285 Shigella sonnei Ss046 IS600 ORF2 YP_312096.1 3462078 D 300269 CDS YP_312097.1 74313678 3668970 3463152..3463493 1 NC_007384.1 hypothetical protein 3463493 yhaV 3668970 yhaV Shigella sonnei Ss046 hypothetical protein YP_312097.1 3463152 D 300269 CDS YP_312098.1 74313679 3668971 complement(3463504..3464007) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3464007 3668971 SSON_3288 Shigella sonnei Ss046 IS1 ORF YP_312098.1 3463504 R 300269 CDS YP_312099.1 74313680 3668972 3464292..3466808 1 NC_007384.1 Code: NU; COG: COG3188; outer membrane protein 3466808 yraJ 3668972 yraJ Shigella sonnei Ss046 outer membrane protein YP_312099.1 3464292 D 300269 CDS YP_312100.2 161986444 3668973 3467403..3468308 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3468308 3668973 SSON_3290 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_312100.2 3467403 D 300269 CDS YP_312101.1 74313682 3668974 3468293..3469246 1 NC_007384.1 Code: NU; COG: COG3539; fimbrial protein 3469246 yraK 3668974 yraK Shigella sonnei Ss046 fimbrial protein YP_312101.1 3468293 D 300269 CDS YP_312102.1 74313683 3668975 complement(3469289..3470149) 1 NC_007384.1 Code: R; COG: COG0313; hypothetical protein 3470149 yraL 3668975 yraL Shigella sonnei Ss046 hypothetical protein YP_312102.1 3469289 R 300269 CDS YP_312103.1 74313684 3668976 3470213..3472249 1 NC_007384.1 Code: R; COG: COG3107; glycosylase 3472249 yraM 3668976 yraM Shigella sonnei Ss046 glycosylase YP_312103.1 3470213 D 300269 CDS YP_312104.1 74313685 3668977 3472207..3472602 1 NC_007384.1 Code: L; COG: COG0792; hypothetical protein 3472602 yraN 3668977 yraN Shigella sonnei Ss046 hypothetical protein YP_312104.1 3472207 D 300269 CDS YP_312105.1 74313686 3668978 3472622..3473212 1 NC_007384.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; chromosome replication initiator DnaA 3473212 yraO 3668978 yraO Shigella sonnei Ss046 chromosome replication initiator DnaA YP_312105.1 3472622 D 300269 CDS YP_312106.1 74313687 3668979 3473222..3473797 1 NC_007384.1 Code: R; COG: COG2823; hypothetical protein 3473797 yraP 3668979 yraP Shigella sonnei Ss046 hypothetical protein YP_312106.1 3473222 D 300269 CDS YP_312107.1 74313688 3668980 complement(3473911..3474951) 1 NC_007384.1 Code: R; COG: COG0701; hypothetical protein 3474951 yraQ 3668980 yraQ Shigella sonnei Ss046 hypothetical protein YP_312107.1 3473911 R 300269 CDS YP_312108.1 74313689 3668981 complement(3475024..3475704) 1 NC_007384.1 Code: MG; COG: COG0702; hypothetical protein 3475704 yraR 3668981 yraR Shigella sonnei Ss046 hypothetical protein YP_312108.1 3475024 R 300269 CDS YP_312109.1 74313690 3667827 3475787..3476305 1 NC_007384.1 Code: R; COG: COG0693; hypothetical protein 3476305 yhbO 3667827 yhbO Shigella sonnei Ss046 hypothetical protein YP_312109.1 3475787 D 300269 CDS YP_312110.1 74313691 3667828 complement(3476285..3476728) 1 NC_007384.1 Code: S; COG: COG3787; hypothetical protein 3476728 yhbP 3667828 yhbP Shigella sonnei Ss046 hypothetical protein YP_312110.1 3476285 R 300269 CDS YP_312111.1 74313692 3667829 3476779..3477081 1 NC_007384.1 Code: L; COG: COG2827; GIY-YIG nuclease superfamily protein 3477081 yhbQ 3667829 yhbQ Shigella sonnei Ss046 GIY-YIG nuclease superfamily protein YP_312111.1 3476779 D 300269 CDS YP_312112.1 74313693 3667830 complement(3477068..3477571) 1 NC_007384.1 Code: R; COG: COG3153; hypothetical protein 3477571 yhbS 3667830 yhbS Shigella sonnei Ss046 hypothetical protein YP_312112.1 3477068 R 300269 CDS YP_312113.1 74313694 3667831 complement(3477565..3478089) 1 NC_007384.1 Code: I; COG: COG3154; hypothetical protein 3478089 yhbT 3667831 yhbT Shigella sonnei Ss046 hypothetical protein YP_312113.1 3477565 R 300269 CDS YP_312114.1 74313695 3667832 3478298..3479293 1 NC_007384.1 Code: O; COG: COG0826; collagenase 3479293 yhbU 3667832 yhbU Shigella sonnei Ss046 collagenase YP_312114.1 3478298 D 300269 CDS YP_312115.1 74313696 3667833 3479284..3480180 1 NC_007384.1 Code: O; COG: COG0826; hypothetical protein 3480180 yhbV 3667833 yhbV Shigella sonnei Ss046 hypothetical protein YP_312115.1 3479284 D 300269 CDS YP_312116.1 74313697 3667834 3480386..3481393 1 NC_007384.1 Code: C; COG: COG2141; hypothetical protein 3481393 yhbW 3667834 yhbW Shigella sonnei Ss046 hypothetical protein YP_312116.1 3480386 D 300269 CDS YP_312117.1 74313698 3667835 complement(3481511..3482755) 1 NC_007384.1 tryptophan transporter of high affinity; tryptophan permease 3482755 mtr 3667835 mtr Shigella sonnei Ss046 tryptophan permease YP_312117.1 3481511 R 300269 CDS YP_312118.2 161986443 3667836 complement(3482909..3484798) 1 NC_007384.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD 3484798 deaD 3667836 deaD Shigella sonnei Ss046 ATP-dependent RNA helicase DeaD YP_312118.2 3482909 R 300269 CDS YP_312119.1 74313700 3667837 complement(3484978..3485862) 1 NC_007384.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI 3485862 yhbM 3667837 yhbM Shigella sonnei Ss046 lipoprotein NlpI YP_312119.1 3484978 R 300269 CDS YP_312120.1 74313701 3667838 complement(3485971..3488175) 1 NC_007384.1 cytidylate kinase activity; Code: J; COG: COG1185; polynucleotide phosphorylase 3488175 pnp 3667838 pnp Shigella sonnei Ss046 polynucleotide phosphorylase YP_312120.1 3485971 R 300269 CDS YP_312121.1 74313702 3667839 complement(3488353..3488622) 1 NC_007384.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 3488622 rpsO 3667839 rpsO Shigella sonnei Ss046 30S ribosomal protein S15 YP_312121.1 3488353 R 300269 CDS YP_312122.1 74313703 3667840 complement(3488771..3489715) 1 NC_007384.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 3489715 truB 3667840 truB Shigella sonnei Ss046 tRNA pseudouridine synthase B YP_312122.1 3488771 R 300269 CDS YP_312123.1 74313704 3667841 complement(3489715..3490116) 1 NC_007384.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 3490116 rbfA 3667841 rbfA Shigella sonnei Ss046 ribosome-binding factor A YP_312123.1 3489715 R 300269 CDS YP_312124.1 74313705 3667842 complement(3490280..3492952) 1 NC_007384.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 3492952 infB 3667842 infB Shigella sonnei Ss046 translation initiation factor IF-2 YP_312124.1 3490280 R 300269 CDS YP_312125.1 74313706 3667843 complement(3492977..3494464) 1 NC_007384.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 3494464 nusA 3667843 nusA Shigella sonnei Ss046 transcription elongation factor NusA YP_312125.1 3492977 R 300269 CDS YP_312126.2 161986442 3667844 complement(3494492..3494944) 1 NC_007384.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 3494944 yhbC 3667844 yhbC Shigella sonnei Ss046 hypothetical protein YP_312126.2 3494492 R 300269 CDS YP_312127.1 74313708 3667505 3495533..3496705 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 3496705 3667505 SSON_3318 Shigella sonnei Ss046 IS21 ORF1 YP_312127.1 3495533 D 300269 CDS YP_312128.1 74313709 3667506 3496705..3497502 1 NC_007384.1 Code: L; COG: COG1484; IS21 ORF2 3497502 3667506 SSON_3319 Shigella sonnei Ss046 IS21 ORF2 YP_312128.1 3496705 D 300269 CDS YP_312129.1 74313710 3667507 3497709..3499052 1 NC_007384.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 3499052 argG 3667507 argG Shigella sonnei Ss046 argininosuccinate synthase YP_312129.1 3497709 D 300269 CDS YP_312130.1 74313711 3667508 complement(3499060..3500667) 1 NC_007384.1 Code: R; COG: COG2194; alkaline phosphatase I 3500667 yhbX 3667508 yhbX Shigella sonnei Ss046 alkaline phosphatase I YP_312130.1 3499060 R 300269 CDS YP_312131.1 74313712 3667510 complement(3501246..3501578) 1 NC_007384.1 protein export - membrane protein; Code: U; COG: COG1314; preprotein translocase subunit SecG 3501578 secG 3667510 secG Shigella sonnei Ss046 preprotein translocase subunit SecG YP_312131.1 3501246 R 300269 CDS YP_312132.1 74313713 3667511 complement(3501806..3503143) 1 NC_007384.1 similar to phosphoglucomutases and phosphomannomutases; catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 3503143 glmM 3667511 glmM Shigella sonnei Ss046 phosphoglucosamine mutase YP_312132.1 3501806 R 300269 CDS YP_312133.2 161986441 3667512 complement(3503136..3503984) 1 NC_007384.1 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase 3503984 folP 3667512 folP Shigella sonnei Ss046 dihydropteroate synthase YP_312133.2 3503136 R 300269 CDS YP_312134.1 74313715 3667513 complement(3504074..3506008) 1 NC_007384.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease 3506008 hflB 3667513 hflB Shigella sonnei Ss046 ATP-dependent metalloprotease YP_312134.1 3504074 R 300269 CDS YP_312135.1 74313716 3667514 complement(3506108..3506737) 1 NC_007384.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase 3506737 rrmJ 3667514 rrmJ Shigella sonnei Ss046 23S rRNA methyltransferase YP_312135.1 3506108 R 300269 CDS YP_312136.1 74313717 3667515 3506863..3507156 1 NC_007384.1 RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 3507156 yhbY 3667515 yhbY Shigella sonnei Ss046 RNA-binding protein YhbY YP_312136.1 3506863 D 300269 CDS YP_312137.2 161986440 3667516 complement(3507312..3507788) 1 NC_007384.1 cleaves 3' nucleotide of paused mRNA; necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 3507788 greA 3667516 greA Shigella sonnei Ss046 transcription elongation factor GreA YP_312137.2 3507312 R 300269 CDS YP_312138.1 74313719 3667517 3508036..3509469 1 NC_007384.1 penicillin-binding protein 4; penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 3509469 dacB 3667517 dacB Shigella sonnei Ss046 D-alanyl-D-alanine carboxypeptidase YP_312138.1 3508036 D 300269 CDS YP_312139.1 74313720 3667518 complement(3509655..3510827) 1 NC_007384.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 3510827 obgE 3667518 obgE Shigella sonnei Ss046 GTPase ObgE YP_312139.1 3509655 R 300269 CDS YP_312140.1 74313721 3667519 complement(3510843..3511808) 1 NC_007384.1 Code: GER; COG: COG0697; hypothetical protein 3511808 yhbE 3667519 yhbE Shigella sonnei Ss046 hypothetical protein YP_312140.1 3510843 R 300269 CDS YP_312141.1 74313722 3667520 complement(3511935..3512192) 1 NC_007384.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 3512192 rpmA 3667520 rpmA Shigella sonnei Ss046 50S ribosomal protein L27 YP_312141.1 3511935 R 300269 CDS YP_312142.1 74313723 3667521 complement(3512213..3512524) 1 NC_007384.1 Code: J; COG: COG0261; 50S ribosomal protein L21 3512524 rplU 3667521 rplU Shigella sonnei Ss046 50S ribosomal protein L21 YP_312142.1 3512213 R 300269 CDS YP_312143.1 74313724 3667522 3512783..3513754 1 NC_007384.1 Code: H; COG: COG0142; octaprenyl diphosphate synthase 3513754 ispB 3667522 ispB Shigella sonnei Ss046 octaprenyl diphosphate synthase YP_312143.1 3512783 D 300269 CDS YP_312144.1 74313725 3667273 3513983..3514261 1 NC_007384.1 activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 3514261 nlp 3667273 nlp Shigella sonnei Ss046 DNA-binding transcriptional regulator Nlp YP_312144.1 3513983 D 300269 CDS YP_312145.1 74313726 3667274 complement(3514309..3515568) 1 NC_007384.1 first step in murein biosynthesis; adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 3515568 murA 3667274 murA Shigella sonnei Ss046 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_312145.1 3514309 R 300269 CDS YP_312146.1 74313727 3667275 complement(3515623..3515892) 1 NC_007384.1 Code: K; COG: COG5007; hypothetical protein 3515892 yrbA 3667275 yrbA Shigella sonnei Ss046 hypothetical protein YP_312146.1 3515623 R 300269 CDS YP_312147.1 74313728 3667276 complement(3516037..3516426) 1 NC_007384.1 Code: R; COG: COG3113; hypothetical protein 3516426 yrbB 3667276 yrbB Shigella sonnei Ss046 hypothetical protein YP_312147.1 3516037 R 300269 CDS YP_312148.1 74313729 3667277 complement(3516330..3516965) 1 NC_007384.1 Code: Q; COG: COG2854; hypothetical protein 3516965 yrbC 3667277 yrbC Shigella sonnei Ss046 hypothetical protein YP_312148.1 3516330 R 300269 CDS YP_312149.1 74313730 3667278 complement(3516984..3517535) 1 NC_007384.1 Code: Q; COG: COG1463; hypothetical protein 3517535 yrbD 3667278 yrbD Shigella sonnei Ss046 hypothetical protein YP_312149.1 3516984 R 300269 CDS YP_312150.1 74313731 3667279 complement(3517540..3518322) 1 NC_007384.1 Code: Q; COG: COG0767; hypothetical protein 3518322 yrbE 3667279 yrbE Shigella sonnei Ss046 hypothetical protein YP_312150.1 3517540 R 300269 CDS YP_312151.1 74313732 3667280 complement(3518330..3519139) 1 NC_007384.1 ATP-binding subunit of a ABC toluene efflux transporter; ABC transporter ATP-binding protein 3519139 yrbF 3667280 yrbF Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_312151.1 3518330 R 300269 CDS YP_312152.1 74313733 3667281 3519349..3520326 1 NC_007384.1 YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; calcium/sodium:proton antiporter 3520326 yrbG 3667281 yrbG Shigella sonnei Ss046 calcium/sodium:proton antiporter YP_312152.1 3519349 D 300269 CDS YP_312153.1 74313734 3667282 3520340..3521326 1 NC_007384.1 Code: M; COG: COG0794; D-arabinose 5-phosphate isomerase 3521326 yrbH 3667282 yrbH Shigella sonnei Ss046 D-arabinose 5-phosphate isomerase YP_312153.1 3520340 D 300269 CDS YP_312154.1 74313735 3667283 3521347..3521913 1 NC_007384.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 3521913 yrbI 3667283 yrbI Shigella sonnei Ss046 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase YP_312154.1 3521347 D 300269 CDS YP_312155.1 74313736 3667284 3521910..3522485 1 NC_007384.1 Code: S; COG: COG3117; hypothetical protein 3522485 yrbK 3667284 yrbK Shigella sonnei Ss046 hypothetical protein YP_312155.1 3521910 D 300269 CDS YP_312156.1 74313737 3667285 3522454..3523011 1 NC_007384.1 LptA; periplasmic binding protein part of a ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 3523011 yhbN 3667285 yhbN Shigella sonnei Ss046 lipopolysaccharide transport periplasmic protein LptA YP_312156.1 3522454 D 300269 CDS YP_312157.1 74313738 3667286 3523018..3523743 1 NC_007384.1 Code: R; COG: COG1137; ABC transporter ATP-binding protein 3523743 yhbG 3667286 yhbG Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_312157.1 3523018 D 300269 CDS YP_312158.1 74313739 3667287 3523791..3525224 1 NC_007384.1 nitrogen and fermentation regulation; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 3525224 rpoN 3667287 rpoN Shigella sonnei Ss046 RNA polymerase factor sigma-54 YP_312158.1 3523791 D 300269 CDS YP_312159.1 74313740 3667288 3525247..3525534 1 NC_007384.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; sigma(54) modulation protein 3525534 yhbH 3667288 yhbH Shigella sonnei Ss046 sigma(54) modulation protein YP_312159.1 3525247 D 300269 CDS YP_312160.1 74313741 3667289 3525652..3526143 1 NC_007384.1 Code: GT; COG: COG1762; PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN 3526143 ptsN 3667289 ptsN Shigella sonnei Ss046 PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN YP_312160.1 3525652 D 300269 CDS YP_312161.1 74313742 3667290 3526189..3527043 1 NC_007384.1 Code: R; COG: COG1660; hypothetical protein 3527043 yhbJ 3667290 yhbJ Shigella sonnei Ss046 hypothetical protein YP_312161.1 3526189 D 300269 CDS YP_312162.1 74313743 3667291 3527040..3527312 1 NC_007384.1 nitrogen-related; exchanges phosphate with enzyme I; Hpr; Code: G; COG: COG1925; PTS system phosphohistidinoprotein-hexose phosphotransferase Npr 3527312 ptsO 3667291 ptsO Shigella sonnei Ss046 PTS system phosphohistidinoprotein-hexose phosphotransferase Npr YP_312162.1 3527040 D 300269 CDS YP_312163.1 74313744 3667292 3527526..3528158 1 NC_007384.1 hypothetical protein 3528158 yrbL 3667292 yrbL Shigella sonnei Ss046 hypothetical protein YP_312163.1 3527526 D 300269 CDS YP_312164.1 74313745 3667025 complement(3528155..3528883) 1 NC_007384.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase 3528883 mtgA 3667025 mtgA Shigella sonnei Ss046 monofunctional biosynthetic peptidoglycan transglycosylase YP_312164.1 3528155 R 300269 CDS YP_312165.1 74313746 3667026 complement(3528880..3529542) 1 NC_007384.1 Code: Q; COG: COG3155; isoprenoid biosynthesis protein 3529542 yhbL 3667026 yhbL Shigella sonnei Ss046 isoprenoid biosynthesis protein YP_312165.1 3528880 R 300269 CDS YP_312166.1 74313747 3667027 complement(3529763..3532099) 1 NC_007384.1 aerobic respiration sensor-response protein; sensor for arcA; sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB 3532099 arcB 3667027 arcB Shigella sonnei Ss046 aerobic respiration control sensor protein ArcB YP_312166.1 3529763 R 300269 CDS YP_312167.1 74313748 3667028 complement(3532195..3533124) 1 NC_007384.1 Code: R; COG: COG1242; hypothetical protein 3533124 yhcC 3667028 yhcC Shigella sonnei Ss046 hypothetical protein YP_312167.1 3532195 R 300269 CDS YP_312168.1 74313749 3667029 3533706..3538259 1 NC_007384.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase subunit alpha 3538259 gltB 3667029 gltB Shigella sonnei Ss046 glutamate synthase subunit alpha YP_312168.1 3533706 D 300269 CDS YP_312169.1 74313750 3667030 3538272..3539690 1 NC_007384.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 3539690 gltD 3667030 gltD Shigella sonnei Ss046 glutamate synthase subunit beta YP_312169.1 3538272 D 300269 CDS YP_312170.1 74313751 3667031 complement(3540751..3541215) 1 NC_007384.1 Code: G; COG: COG2731; hypothetical protein 3541215 yhcH 3667031 yhcH Shigella sonnei Ss046 hypothetical protein YP_312170.1 3540751 R 300269 CDS YP_312171.2 161986439 3667032 complement(3541212..3542087) 1 NC_007384.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 3542087 yhcI 3667032 yhcI Shigella sonnei Ss046 N-acetylmannosamine kinase YP_312171.2 3541212 R 300269 CDS YP_312172.1 74313753 3667033 complement(3542084..3542773) 1 NC_007384.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 3542773 yhcJ 3667033 yhcJ Shigella sonnei Ss046 N-acetylmannosamine-6-phosphate 2-epimerase YP_312172.1 3542084 R 300269 CDS YP_312173.2 161986438 3667034 complement(3542821..3544311) 1 NC_007384.1 Code: GEPR; COG: COG0477; sialic acid transporter 3544311 nanT 3667034 nanT Shigella sonnei Ss046 sialic acid transporter YP_312173.2 3542821 R 300269 CDS YP_312174.1 74313755 3667035 complement(3544421..3545314) 1 NC_007384.1 aldolase; catabolism of sialic acid; catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 3545314 nanA 3667035 nanA Shigella sonnei Ss046 N-acetylneuraminate lyase YP_312174.1 3544421 R 300269 CDS YP_312175.1 74313756 3667036 complement(3545436..3546227) 1 NC_007384.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR 3546227 yhcK 3667036 yhcK Shigella sonnei Ss046 transcriptional regulator NanR YP_312175.1 3545436 R 300269 CDS YP_312176.1 74313757 3667037 3546607..3547929 1 NC_007384.1 YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic; cryptic C4-dicarboxylate transporter DcuD 3547929 yhcL 3667037 yhcL Shigella sonnei Ss046 cryptic C4-dicarboxylate transporter DcuD YP_312176.1 3546607 D 300269 CDS YP_312177.1 74313758 3667038 complement(3547972..3548469) 1 NC_007384.1 Code: R; COG: COG2969; ClpXP protease specificity-enhancing factor 3548469 sspB 3667038 sspB Shigella sonnei Ss046 ClpXP protease specificity-enhancing factor YP_312177.1 3547972 R 300269 CDS YP_312178.1 74313759 3667039 complement(3548475..3549113) 1 NC_007384.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A 3549113 sspA 3667039 sspA Shigella sonnei Ss046 stringent starvation protein A YP_312178.1 3548475 R 300269 CDS YP_312179.1 74313760 3667040 complement(3549508..3549900) 1 NC_007384.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 3549900 rpsI 3667040 rpsI Shigella sonnei Ss046 30S ribosomal protein S9 YP_312179.1 3549508 R 300269 CDS YP_312180.1 74313761 3667041 complement(3549916..3550344) 1 NC_007384.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 3550344 rplM 3667041 rplM Shigella sonnei Ss046 50S ribosomal protein L13 YP_312180.1 3549916 R 300269 CDS YP_312181.1 74313762 3667042 complement(3550563..3551690) 1 NC_007384.1 Code: R; COG: COG1485; hypothetical protein 3551690 yhcM 3667042 yhcM Shigella sonnei Ss046 hypothetical protein YP_312181.1 3550563 R 300269 CDS YP_312182.1 74313763 3667043 3551878..3552282 1 NC_007384.1 Code: S; COG: COG3105; cytochrome d ubiquinol oxidase subunit III 3552282 yhcB 3667043 yhcB Shigella sonnei Ss046 cytochrome d ubiquinol oxidase subunit III YP_312182.1 3551878 D 300269 CDS YP_312183.1 74313764 3667389 3552436..3553803 1 NC_007384.1 Code: O; COG: COG0265; serine endoprotease 3553803 degQ 3667389 degQ Shigella sonnei Ss046 serine endoprotease YP_312183.1 3552436 D 300269 CDS YP_312184.1 74313765 3667390 3553893..3554960 1 NC_007384.1 Code: O; COG: COG0265; serine endoprotease 3554960 degS 3667390 degS Shigella sonnei Ss046 serine endoprotease YP_312184.1 3553893 D 300269 CDS YP_312185.1 74313766 3667391 complement(3555011..3556357) 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 3556357 3667391 SSON_3377 Shigella sonnei Ss046 IS4 orf YP_312185.1 3555011 R 300269 CDS YP_312186.1 74313767 3667392 complement(3556461..3557399) 1 NC_007384.1 oxidizes malate to oxaloacetate; malate dehydrogenase 3557399 mdh 3667392 mdh Shigella sonnei Ss046 malate dehydrogenase YP_312186.1 3556461 R 300269 CDS YP_312187.1 74313768 3667393 3557834..3558304 1 NC_007384.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 3558304 argR 3667393 argR Shigella sonnei Ss046 arginine repressor ArgR YP_312187.1 3557834 D 300269 CDS YP_312188.1 74313769 3667394 3558618..3558932 1 NC_007384.1 hypothetical protein 3558932 yhcN 3667394 yhcN Shigella sonnei Ss046 hypothetical protein YP_312188.1 3558618 D 300269 CDS YP_312189.1 74313770 3667395 complement(3558988..3559260) 1 NC_007384.1 Code: K; COG: COG2732; hypothetical protein 3559260 yhcO 3667395 yhcO Shigella sonnei Ss046 hypothetical protein YP_312189.1 3558988 R 300269 CDS YP_312190.1 74313771 3667396 complement(3559352..3561319) 1 NC_007384.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB 3561319 yhcP 3667396 yhcP Shigella sonnei Ss046 p-hydroxybenzoic acid efflux subunit AaeB YP_312190.1 3559352 R 300269 CDS YP_312191.1 74313772 3667397 complement(3561325..3562257) 1 NC_007384.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA 3562257 yhcQ 3667397 yhcQ Shigella sonnei Ss046 p-hydroxybenzoic acid efflux subunit AaeA YP_312191.1 3561325 R 300269 CDS YP_312192.2 161986437 3667398 complement(3562265..3562468) 1 NC_007384.1 membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein 3562468 yhcR 3667398 yhcR Shigella sonnei Ss046 hypothetical protein YP_312192.2 3562265 R 300269 CDS YP_312193.1 74313774 3667400 complement(3563644..3565089) 1 NC_007384.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD 3565089 tldD 3667400 tldD Shigella sonnei Ss046 protease TldD YP_312193.1 3563644 R 300269 CDS YP_312194.1 74313775 3667401 complement(3565245..3569045) 1 NC_007384.1 Code: S; COG: COG3164; hypothetical protein 3569045 yhdRP 3667401 yhdRP Shigella sonnei Ss046 hypothetical protein YP_312194.1 3565245 R 300269 CDS YP_312195.2 161986436 3667402 complement(3569113..3570582) 1 NC_007384.1 involved in the processing of the 5'end of 16S rRNA; ribonuclease G 3570582 cafA 3667402 cafA Shigella sonnei Ss046 ribonuclease G YP_312195.2 3569113 R 300269 CDS YP_312196.1 74313777 3667403 complement(3570572..3571165) 1 NC_007384.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 3571165 yhdE 3667403 yhdE Shigella sonnei Ss046 Maf-like protein YP_312196.1 3570572 R 300269 CDS YP_312197.1 74313778 3667404 complement(3571174..3571662) 1 NC_007384.1 part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD 3571662 mreD 3667404 mreD Shigella sonnei Ss046 rod shape-determining protein MreD YP_312197.1 3571174 R 300269 CDS YP_312198.1 74313779 3667405 complement(3571662..3572765) 1 NC_007384.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 3572765 mreC 3667405 mreC Shigella sonnei Ss046 rod shape-determining protein MreC YP_312198.1 3571662 R 300269 CDS YP_312199.2 228861779 3667406 complement(3572831..3573874) 1 NC_007384.1 penicillin binding protein 3; septation function; functions in MreBCD complex in some organisms; rod shape-determining protein MreB 3573874 mreB 3667406 mreB Shigella sonnei Ss046 rod shape-determining protein MreB YP_312199.2 3572831 R 300269 CDS YP_312200.1 74313781 3667407 complement(3574179..3576119) 1 NC_007384.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD 3576119 yhdA 3667407 yhdA Shigella sonnei Ss046 regulatory protein CsrD YP_312200.1 3574179 R 300269 CDS YP_312201.1 74313782 3667408 3576271..3577245 1 NC_007384.1 Code: CR; COG: COG0604; dehydrogenase 3577245 yhdH 3667408 yhdH Shigella sonnei Ss046 dehydrogenase YP_312201.1 3576271 D 300269 CDS YP_312202.1 74313783 3667370 complement(3577303..3577404) 1 NC_007384.1 hypothetical protein 3577404 3667370 SSON_3395 Shigella sonnei Ss046 hypothetical protein YP_312202.1 3577303 R 300269 CDS YP_312203.1 74313784 3667371 3578223..3578693 1 NC_007384.1 carrier of biotin; composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3578693 accB 3667371 accB Shigella sonnei Ss046 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_312203.1 3578223 D 300269 CDS YP_312204.1 74313785 3667372 3578704..3580053 1 NC_007384.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 3580053 accC 3667372 accC Shigella sonnei Ss046 acetyl-CoA carboxylase biotin carboxylase subunit YP_312204.1 3578704 D 300269 CDS YP_312205.1 74313786 3667373 3580162..3580404 1 NC_007384.1 Code: S; COG: COG3924; hypothetical protein 3580404 yhdT 3667373 yhdT Shigella sonnei Ss046 hypothetical protein YP_312205.1 3580162 D 300269 CDS YP_312206.2 161986435 3667374 3580394..3581845 1 NC_007384.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 3581845 panF 3667374 panF Shigella sonnei Ss046 sodium/panthothenate symporter YP_312206.2 3580394 D 300269 CDS YP_312207.1 74313788 3667375 3581857..3582738 1 NC_007384.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 3582738 prmA 3667375 prmA Shigella sonnei Ss046 50S ribosomal protein L11 methyltransferase YP_312207.1 3581857 D 300269 CDS YP_312208.1 74313789 3667376 3583067..3584032 1 NC_007384.1 Code: J; COG: COG0042; tRNA-dihydrouridine synthase B 3584032 yhdG 3667376 yhdG Shigella sonnei Ss046 tRNA-dihydrouridine synthase B YP_312208.1 3583067 D 300269 CDS YP_312209.1 74313790 3667377 3584058..3584354 1 NC_007384.1 DNA-binding protein; Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; Fis family transcriptional regulator 3584354 fis 3667377 fis Shigella sonnei Ss046 Fis family transcriptional regulator YP_312209.1 3584058 D 300269 CDS YP_312210.2 161986434 3667378 3584440..3585324 1 NC_007384.1 Code: L; COG: COG0863; methyltransferase 3585324 yhdJ 3667378 yhdJ Shigella sonnei Ss046 methyltransferase YP_312210.2 3584440 D 300269 CDS YP_312211.1 74313792 3667379 3585408..3585587 1 NC_007384.1 hypothetical protein 3585587 yhdU 3667379 yhdU Shigella sonnei Ss046 hypothetical protein YP_312211.1 3585408 D 300269 CDS YP_312212.1 74313793 3667380 complement(3585590..3586252) 1 NC_007384.1 Code: K; COG: COG1309; DNA-binding transcriptional regulator EnvR 3586252 envR 3667380 envR Shigella sonnei Ss046 DNA-binding transcriptional regulator EnvR YP_312212.1 3585590 R 300269 CDS YP_312213.1 74313794 3667381 3586651..3587808 1 NC_007384.1 transmembrane protein affects septum formation and cell membrane permeability; Code: M; COG: COG0845; AcrE protein 3587808 acrE 3667381 acrE Shigella sonnei Ss046 AcrE protein YP_312213.1 3586651 D 300269 CDS YP_312214.1 74313795 3667383 3591150..3591653 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3591653 3667383 SSON_3408 Shigella sonnei Ss046 IS1 ORF YP_312214.1 3591150 D 300269 CDS YP_312215.1 74313796 3667384 3592110..3593027 1 NC_007384.1 Code: ET; COG: COG0834; periplasmic binding transport protein 3593027 yhdW 3667384 yhdW Shigella sonnei Ss046 periplasmic binding transport protein YP_312215.1 3592110 D 300269 CDS YP_312216.1 74313797 3667386 3594283..3595389 1 NC_007384.1 Code: E; COG: COG0765; transport system permease 3595389 yhdY 3667386 yhdY Shigella sonnei Ss046 transport system permease YP_312216.1 3594283 D 300269 CDS YP_312217.1 74313798 3667387 3595397..3596155 1 NC_007384.1 Code: E; COG: COG1126; ABC transporter ATP-binding protein 3596155 yhdZ 3667387 yhdZ Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_312217.1 3595397 D 300269 CDS YP_312218.1 74313799 3666979 3601820..3602590 1 NC_007384.1 Code: R; COG: COG0663; transferase 3602590 yrdA 3666979 yrdA Shigella sonnei Ss046 transferase YP_312218.1 3601820 D 300269 CDS YP_312219.1 74313800 3666980 complement(3602566..3602823) 1 NC_007384.1 hypothetical protein 3602823 yrdB 3666980 yrdB Shigella sonnei Ss046 hypothetical protein YP_312219.1 3602566 R 300269 CDS YP_312220.1 74313801 3666981 complement(3602820..3603638) 1 NC_007384.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 3603638 aroE 3666981 aroE Shigella sonnei Ss046 shikimate 5-dehydrogenase YP_312220.1 3602820 R 300269 CDS YP_312221.1 74313802 3666982 complement(3603643..3604215) 1 NC_007384.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; ribosome maturation factor 3604215 yrdC 3666982 yrdC Shigella sonnei Ss046 ribosome maturation factor YP_312221.1 3603643 R 300269 CDS YP_312222.1 74313803 3666984 complement(3604791..3605264) 1 NC_007384.1 Code: S; COG: COG2922; hypothetical protein 3605264 smg 3666984 smg Shigella sonnei Ss046 hypothetical protein YP_312222.1 3604791 R 300269 CDS YP_312223.1 74313804 3666985 complement(3605236..3606360) 1 NC_007384.1 involved in DNA uptake; Code: LU; COG: COG0758; DNA protecting protein DprA 3606360 smf 3666985 smf Shigella sonnei Ss046 DNA protecting protein DprA YP_312223.1 3605236 R 300269 CDS YP_312224.1 74313805 3667523 3606490..3606999 1 NC_007384.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 3606999 def 3667523 def Shigella sonnei Ss046 peptide deformylase YP_312224.1 3606490 D 300269 CDS YP_312225.1 74313806 3667524 3607014..3607961 1 NC_007384.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 3607961 fmt 3667524 fmt Shigella sonnei Ss046 methionyl-tRNA formyltransferase YP_312225.1 3607014 D 300269 CDS YP_312226.1 74313807 3667525 3608007..3609296 1 NC_007384.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase GidB 3609296 sun 3667525 sun Shigella sonnei Ss046 16S rRNA methyltransferase GidB YP_312226.1 3608007 D 300269 CDS YP_312227.1 74313808 3667526 3609318..3610694 1 NC_007384.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 3610694 trkA 3667526 trkA Shigella sonnei Ss046 potassium transporter peripheral membrane protein YP_312227.1 3609318 D 300269 CDS YP_312228.1 74313809 3667527 3610824..3611234 1 NC_007384.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 3611234 mscL 3667527 mscL Shigella sonnei Ss046 large-conductance mechanosensitive channel YP_312228.1 3610824 D 300269 CDS YP_312229.1 74313810 3667528 complement(3611231..3611449) 1 NC_007384.1 Code: S; COG: COG3036; hypothetical protein 3611449 yhdL 3667528 yhdL Shigella sonnei Ss046 hypothetical protein YP_312229.1 3611231 R 300269 CDS YP_312230.1 74313811 3667529 complement(3611505..3611930) 1 NC_007384.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator 3611930 zntR 3667529 zntR Shigella sonnei Ss046 zinc-responsive transcriptional regulator YP_312230.1 3611505 R 300269 CDS YP_312231.1 74313812 3667530 complement(3611941..3612309) 1 NC_007384.1 hypothetical protein 3612309 yhdN 3667530 yhdN Shigella sonnei Ss046 hypothetical protein YP_312231.1 3611941 R 300269 CDS YP_312232.1 74313813 3667531 complement(3612416..3612799) 1 NC_007384.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 3612799 rplQ 3667531 rplQ Shigella sonnei Ss046 50S ribosomal protein L17 YP_312232.1 3612416 R 300269 CDS YP_312233.1 74313814 3667532 complement(3612840..3613829) 1 NC_007384.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 3613829 rpoA 3667532 rpoA Shigella sonnei Ss046 DNA-directed RNA polymerase subunit alpha YP_312233.1 3612840 R 300269 CDS YP_312234.1 74313815 3667533 complement(3613855..3614475) 1 NC_007384.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 3614475 rpsD 3667533 rpsD Shigella sonnei Ss046 30S ribosomal protein S4 YP_312234.1 3613855 R 300269 CDS YP_312235.1 74313816 3667534 complement(3614509..3614898) 1 NC_007384.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 3614898 rpsK 3667534 rpsK Shigella sonnei Ss046 30S ribosomal protein S11 YP_312235.1 3614509 R 300269 CDS YP_312236.1 74313817 3667535 complement(3614915..3615271) 1 NC_007384.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 3615271 rpsM 3667535 rpsM Shigella sonnei Ss046 30S ribosomal protein S13 YP_312236.1 3614915 R 300269 CDS YP_312237.1 74313818 3667536 complement(3615418..3615534) 1 NC_007384.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 3615534 rpmJ 3667536 rpmJ Shigella sonnei Ss046 50S ribosomal protein L36 YP_312237.1 3615418 R 300269 CDS YP_312238.1 74313819 3667537 complement(3615566..3616897) 1 NC_007384.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 3616897 secY 3667537 secY Shigella sonnei Ss046 preprotein translocase subunit SecY YP_312238.1 3615566 R 300269 CDS YP_312239.1 74313820 3667538 complement(3616905..3617339) 1 NC_007384.1 late assembly protein; 50S ribosomal protein L15 3617339 rplO 3667538 rplO Shigella sonnei Ss046 50S ribosomal protein L15 YP_312239.1 3616905 R 300269 CDS YP_312240.1 74313821 3667539 complement(3617343..3617522) 1 NC_007384.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 3617522 rpmD 3667539 rpmD Shigella sonnei Ss046 50S ribosomal protein L30 YP_312240.1 3617343 R 300269 CDS YP_312241.1 74313822 3667540 complement(3617526..3618029) 1 NC_007384.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 3618029 rpsE 3667540 rpsE Shigella sonnei Ss046 30S ribosomal protein S5 YP_312241.1 3617526 R 300269 CDS YP_312242.1 74313823 3667541 complement(3618044..3618397) 1 NC_007384.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 3618397 rplR 3667541 rplR Shigella sonnei Ss046 50S ribosomal protein L18 YP_312242.1 3618044 R 300269 CDS YP_312243.1 74313824 3666875 complement(3618407..3618940) 1 NC_007384.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 3618940 rplF 3666875 rplF Shigella sonnei Ss046 50S ribosomal protein L6 YP_312243.1 3618407 R 300269 CDS YP_312244.1 74313825 3666876 complement(3618953..3619345) 1 NC_007384.1 includes regulator; binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 3619345 rpsH 3666876 rpsH Shigella sonnei Ss046 30S ribosomal protein S8 YP_312244.1 3618953 R 300269 CDS YP_312245.1 74313826 3666877 complement(3619379..3619684) 1 NC_007384.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 3619684 rpsN 3666877 rpsN Shigella sonnei Ss046 30S ribosomal protein S14 YP_312245.1 3619379 R 300269 CDS YP_312246.1 74313827 3666878 complement(3619699..3620238) 1 NC_007384.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 3620238 rplE 3666878 rplE Shigella sonnei Ss046 50S ribosomal protein L5 YP_312246.1 3619699 R 300269 CDS YP_312247.1 74313828 3666879 complement(3620253..3620567) 1 NC_007384.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 3620567 rplX 3666879 rplX Shigella sonnei Ss046 50S ribosomal protein L24 YP_312247.1 3620253 R 300269 CDS YP_312248.1 74313829 3666880 complement(3620578..3620949) 1 NC_007384.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 3620949 rplN 3666880 rplN Shigella sonnei Ss046 50S ribosomal protein L14 YP_312248.1 3620578 R 300269 CDS YP_312249.1 74313830 3666881 complement(3621112..3621366) 1 NC_007384.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 3621366 rpsQ 3666881 rpsQ Shigella sonnei Ss046 30S ribosomal protein S17 YP_312249.1 3621112 R 300269 CDS YP_312250.1 74313831 3666882 complement(3621366..3621557) 1 NC_007384.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 3621557 rpmC 3666882 rpmC Shigella sonnei Ss046 50S ribosomal protein L29 YP_312250.1 3621366 R 300269 CDS YP_312251.1 74313832 3666883 complement(3621557..3621967) 1 NC_007384.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 3621967 rplP 3666883 rplP Shigella sonnei Ss046 50S ribosomal protein L16 YP_312251.1 3621557 R 300269 CDS YP_312252.1 74313833 3666884 complement(3621980..3622681) 1 NC_007384.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 3622681 rpsC 3666884 rpsC Shigella sonnei Ss046 30S ribosomal protein S3 YP_312252.1 3621980 R 300269 CDS YP_312253.1 74313834 3666885 complement(3622699..3623031) 1 NC_007384.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 3623031 rplV 3666885 rplV Shigella sonnei Ss046 50S ribosomal protein L22 YP_312253.1 3622699 R 300269 CDS YP_312254.1 74313835 3666886 complement(3623046..3623324) 1 NC_007384.1 Code: J; COG: COG0185; 30S ribosomal protein S19 3623324 rpsS 3666886 rpsS Shigella sonnei Ss046 30S ribosomal protein S19 YP_312254.1 3623046 R 300269 CDS YP_312255.1 74313836 3666887 complement(3623341..3624162) 1 NC_007384.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 3624162 rplB 3666887 rplB Shigella sonnei Ss046 50S ribosomal protein L2 YP_312255.1 3623341 R 300269 CDS YP_312256.1 74313837 3666888 complement(3624180..3624482) 1 NC_007384.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 3624482 rplW 3666888 rplW Shigella sonnei Ss046 50S ribosomal protein L23 YP_312256.1 3624180 R 300269 CDS YP_312257.1 74313838 3666889 complement(3624479..3625084) 1 NC_007384.1 regulates expression of S10 operon; L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 3625084 rplD 3666889 rplD Shigella sonnei Ss046 50S ribosomal protein L4 YP_312257.1 3624479 R 300269 CDS YP_312258.1 74313839 3666890 complement(3625095..3625724) 1 NC_007384.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 3625724 rplC 3666890 rplC Shigella sonnei Ss046 50S ribosomal protein L3 YP_312258.1 3625095 R 300269 CDS YP_312259.1 74313840 3666891 complement(3625757..3626068) 1 NC_007384.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 3626068 rpsJ 3666891 rpsJ Shigella sonnei Ss046 30S ribosomal protein S10 YP_312259.1 3625757 R 300269 CDS YP_312260.1 74313841 3666892 complement(3626306..3626725) 1 NC_007384.1 calcium-binding protein that may be required for the initiation of chromosome replication; chromosome replication protein PioO 3626725 pinO 3666892 pinO Shigella sonnei Ss046 chromosome replication protein PioO YP_312260.1 3626306 R 300269 CDS YP_312261.1 74313842 3666893 complement(3627274..3628071) 1 NC_007384.1 Code: L; COG: COG1484; IS21 ORF2 3628071 3666893 SSON_3464 Shigella sonnei Ss046 IS21 ORF2 YP_312261.1 3627274 R 300269 CDS YP_312262.1 74313843 3666894 complement(3628071..3629243) 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 3629243 3666894 SSON_3465 Shigella sonnei Ss046 IS21 ORF1 YP_312262.1 3628071 R 300269 CDS YP_312263.1 74313844 3666838 3630813..3631316 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3631316 3666838 SSON_3467 Shigella sonnei Ss046 IS1 ORF YP_312263.1 3630813 D 300269 CDS YP_312264.1 74313845 3666840 complement(3632144..3633328) 1 NC_007384.1 duplicate of tufB; EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 3633328 tufA 3666840 tufA Shigella sonnei Ss046 elongation factor Tu YP_312264.1 3632144 R 300269 CDS YP_312265.1 74313846 3666841 complement(3633399..3635513) 1 NC_007384.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 3635513 fusA 3666841 fusA Shigella sonnei Ss046 elongation factor G YP_312265.1 3633399 R 300269 CDS YP_312266.1 74313847 3666842 complement(3635610..3636080) 1 NC_007384.1 initiates assembly; binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 3636080 rpsG 3666842 rpsG Shigella sonnei Ss046 30S ribosomal protein S7 YP_312266.1 3635610 R 300269 CDS YP_312267.1 74313848 3666843 complement(3636177..3636551) 1 NC_007384.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 3636551 rpsL 3666843 rpsL Shigella sonnei Ss046 30S ribosomal protein S12 YP_312267.1 3636177 R 300269 CDS YP_312268.1 74313849 3666844 complement(3636677..3636964) 1 NC_007384.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB 3636964 yheL 3666844 yheL Shigella sonnei Ss046 sulfur transfer complex subunit TusB YP_312268.1 3636677 R 300269 CDS YP_312269.1 74313850 3666845 complement(3636972..3637331) 1 NC_007384.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC 3637331 yheM 3666845 yheM Shigella sonnei Ss046 sulfur relay protein TusC YP_312269.1 3636972 R 300269 CDS YP_312270.1 74313851 3666846 complement(3637331..3637717) 1 NC_007384.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 3637717 yheN 3666846 yheN Shigella sonnei Ss046 sulfur transfer complex subunit TusD YP_312270.1 3637331 R 300269 CDS YP_312271.1 74313852 3666847 complement(3637717..3638451) 1 NC_007384.1 Code: S; COG: COG2964; hypothetical protein 3638451 yheO 3666847 yheO Shigella sonnei Ss046 hypothetical protein YP_312271.1 3637717 R 300269 CDS YP_312272.1 74313853 3666848 complement(3638606..3639418) 1 NC_007384.1 rotamase; FKBP-type peptidylprolyl isomerase 3639418 fkpA 3666848 fkpA Shigella sonnei Ss046 FKBP-type peptidylprolyl isomerase YP_312272.1 3638606 R 300269 CDS YP_312273.1 74313854 3666849 3639639..3639857 1 NC_007384.1 Code: S; COG: COG2900; hypothetical protein 3639857 slyX 3666849 slyX Shigella sonnei Ss046 hypothetical protein YP_312273.1 3639639 D 300269 CDS YP_312274.1 74313855 3666850 complement(3639906..3640496) 1 NC_007384.1 rotamase; FKBP-type peptidylprolyl isomerase 3640496 slyD 3666850 slyD Shigella sonnei Ss046 FKBP-type peptidylprolyl isomerase YP_312274.1 3639906 R 300269 CDS YP_312275.1 74313856 3666851 complement(3640591..3640791) 1 NC_007384.1 Code: R; COG: COG3529; hypothetical protein 3640791 3666851 SSON_3480 Shigella sonnei Ss046 hypothetical protein YP_312275.1 3640591 R 300269 CDS YP_312276.1 74313857 3666852 complement(3640801..3642606) 1 NC_007384.1 involved in potassium efflux; glutathione-regulated potassium-efflux system protein KefB 3642606 kefB 3666852 kefB Shigella sonnei Ss046 glutathione-regulated potassium-efflux system protein KefB YP_312276.1 3640801 R 300269 CDS YP_312277.1 74313858 3666853 complement(3642606..3643160) 1 NC_007384.1 required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG 3643160 yheR 3666853 yheR Shigella sonnei Ss046 glutathione-regulated potassium-efflux system ancillary protein KefG YP_312277.1 3642606 R 300269 CDS YP_312278.1 74313859 3666854 3643288..3645201 1 NC_007384.1 Code: R; COG: COG0488; ABC transporter ATP-binding protein 3645201 yheS 3666854 yheS Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_312278.1 3643288 D 300269 CDS YP_312279.1 74313860 3666855 3645201..3646223 1 NC_007384.1 Code: R; COG: COG0429; hydrolase 3646223 yheT 3666855 yheT Shigella sonnei Ss046 hydrolase YP_312279.1 3645201 D 300269 CDS YP_312280.1 74313861 3666635 3646217..3646435 1 NC_007384.1 Code: S; COG: COG3089; hypothetical protein 3646435 yheU 3666635 yheU Shigella sonnei Ss046 hypothetical protein YP_312280.1 3646217 D 300269 CDS YP_312281.1 74313862 3666636 3646489..3647358 1 NC_007384.1 Code: C; COG: COG3954; phosphoribulokinase 3647358 prkB 3666636 prkB Shigella sonnei Ss046 phosphoribulokinase YP_312281.1 3646489 D 300269 CDS YP_312282.1 74313863 3666637 complement(3647413..3647817) 1 NC_007384.1 Code: O; COG: COG1765; hypothetical protein 3647817 yhfA 3666637 yhfA Shigella sonnei Ss046 hypothetical protein YP_312282.1 3647413 R 300269 CDS YP_312283.1 74313864 3666638 3648119..3648751 1 NC_007384.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 3648751 crp 3666638 crp Shigella sonnei Ss046 cAMP-regulatory protein YP_312283.1 3648119 D 300269 CDS YP_312284.1 74313865 3666639 3648802..3650892 1 NC_007384.1 Code: S; COG: COG1289; hypothetical protein 3650892 yhfK 3666639 yhfK Shigella sonnei Ss046 hypothetical protein YP_312284.1 3648802 D 300269 CDS YP_312285.1 74313866 3666640 complement(3650959..3652179) 1 NC_007384.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase 3652179 argD 3666640 argD Shigella sonnei Ss046 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase YP_312285.1 3650959 R 300269 CDS YP_312286.1 74313867 3666641 complement(3652265..3652828) 1 NC_007384.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 3652828 pabA 3666641 pabA Shigella sonnei Ss046 para-aminobenzoate synthase component II YP_312286.1 3652265 R 300269 CDS YP_312287.1 74313868 3666642 complement(3652860..3653462) 1 NC_007384.1 induced in stationary phase, recognized by rpoS, affects cell division; Code: D; COG: COG2184; cell filamentation protein Fic 3653462 fic 3666642 fic Shigella sonnei Ss046 cell filamentation protein Fic YP_312287.1 3652860 R 300269 CDS YP_312288.1 74313869 3666643 complement(3653452..3653619) 1 NC_007384.1 hypothetical protein 3653619 yhfG 3666643 yhfG Shigella sonnei Ss046 hypothetical protein YP_312288.1 3653452 R 300269 CDS YP_312289.1 74313870 3666644 complement(3653724..3654296) 1 NC_007384.1 rotamase A; Code: O; COG: COG0652; peptidyl-prolyl cis-trans isomerase A 3654296 ppiA 3666644 ppiA Shigella sonnei Ss046 peptidyl-prolyl cis-trans isomerase A YP_312289.1 3653724 R 300269 CDS YP_312290.1 74313871 3666645 3654567..3655748 1 NC_007384.1 Code: GEPR; COG: COG0477; hypothetical protein 3655748 yhfC 3666645 yhfC Shigella sonnei Ss046 hypothetical protein YP_312290.1 3654567 D 300269 CDS YP_312291.1 74313872 3666646 3656010..3658553 1 NC_007384.1 Code: C; COG: COG1251; nitrite reductase (NAD(P)H) subunit 3658553 nirB 3666646 nirB Shigella sonnei Ss046 nitrite reductase (NAD(P)H) subunit YP_312291.1 3656010 D 300269 CDS YP_312292.1 74313873 3666647 3658550..3658876 1 NC_007384.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 3658876 nirD 3666647 nirD Shigella sonnei Ss046 nitrite reductase small subunit YP_312292.1 3658550 D 300269 CDS YP_312293.1 74313874 3666648 3659002..3659808 1 NC_007384.1 member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 3659808 nirC 3666648 nirC Shigella sonnei Ss046 nitrite transporter NirC YP_312293.1 3659002 D 300269 CDS YP_312294.1 74313875 3666649 3659827..3661200 1 NC_007384.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 3661200 cysG 3666649 cysG Shigella sonnei Ss046 siroheme synthase YP_312294.1 3659827 D 300269 CDS YP_312295.1 74313876 3666650 3661447..3661614 1 NC_007384.1 hypothetical protein 3661614 yhfL 3666650 yhfL Shigella sonnei Ss046 hypothetical protein YP_312295.1 3661447 D 300269 CDS YP_312296.1 74313877 3666651 complement(3661929..3662432) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3662432 3666651 SSON_3501 Shigella sonnei Ss046 IS1 ORF YP_312296.1 3661929 R 300269 CDS YP_312297.1 74313878 3666652 3662686..3664023 1 NC_007384.1 inner membrane protein possibly involved in fructoselysine transport; member of the flr operon; fructoselysine transporter 3664023 frlA 3666652 frlA Shigella sonnei Ss046 fructoselysine transporter YP_312297.1 3662686 D 300269 CDS YP_312298.1 74313879 3666653 3664023..3665066 1 NC_007384.1 catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine; fructoselysine-6-P-deglycase 3665066 frlB 3666653 frlB Shigella sonnei Ss046 fructoselysine-6-P-deglycase YP_312298.1 3664023 D 300269 CDS YP_312299.1 74313880 3666654 3665116..3665826 1 NC_007384.1 Code: G; COG: COG1082; hypothetical protein 3665826 yhfP 3666654 yhfP Shigella sonnei Ss046 hypothetical protein YP_312299.1 3665116 D 300269 CDS YP_312300.1 74313881 3667351 3665944..3666729 1 NC_007384.1 Code: G; COG: COG0524; fructoselysine 6-kinase 3666729 yhfQ 3667351 yhfQ Shigella sonnei Ss046 fructoselysine 6-kinase YP_312300.1 3665944 D 300269 CDS YP_312301.1 74313882 3667352 3666763..3667560 1 NC_007384.1 may act as a transcriptional regulator of a fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes; DNA-binding transcriptional regulator FrlR 3667560 yhfR 3667352 yhfR Shigella sonnei Ss046 DNA-binding transcriptional regulator FrlR YP_312301.1 3666763 D 300269 CDS YP_312302.1 74313883 3667353 complement(3667712..3668797) 1 NC_007384.1 hypothetical protein 3668797 yhfS 3667353 yhfS Shigella sonnei Ss046 hypothetical protein YP_312302.1 3667712 R 300269 CDS YP_312303.1 74313884 3667354 complement(3668809..3670113) 1 NC_007384.1 transport system permease 3670113 yhfT 3667354 yhfT Shigella sonnei Ss046 transport system permease YP_312303.1 3668809 R 300269 CDS YP_312304.1 74313885 3667355 complement(3670125..3670517) 1 NC_007384.1 hypothetical protein 3670517 yhfU 3667355 yhfU Shigella sonnei Ss046 hypothetical protein YP_312304.1 3670125 R 300269 CDS YP_312305.1 74313886 3667356 complement(3670489..3671367) 1 NC_007384.1 phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE); hydrolase 3671367 yhfV 3667356 yhfV Shigella sonnei Ss046 hydrolase YP_312305.1 3670489 R 300269 CDS YP_312306.1 74313887 3667359 complement(3673837..3674241) 1 NC_007384.1 hypothetical protein 3674241 yhfY 3667359 yhfY Shigella sonnei Ss046 hypothetical protein YP_312306.1 3673837 R 300269 CDS YP_312307.1 74313888 3667360 complement(3674216..3674902) 1 NC_007384.1 hypothetical protein 3674902 yhfZ 3667360 yhfZ Shigella sonnei Ss046 hypothetical protein YP_312307.1 3674216 R 300269 CDS YP_312308.1 74313889 3667361 complement(3675281..3676285) 1 NC_007384.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 3676285 trpS 3667361 trpS Shigella sonnei Ss046 tryptophanyl-tRNA synthetase YP_312308.1 3675281 R 300269 CDS YP_312309.1 74313890 3667362 complement(3676278..3677036) 1 NC_007384.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 3677036 gph 3667362 gph Shigella sonnei Ss046 phosphoglycolate phosphatase YP_312309.1 3676278 R 300269 CDS YP_312310.1 74313891 3667363 complement(3677029..3677706) 1 NC_007384.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 3677706 rpe 3667363 rpe Shigella sonnei Ss046 ribulose-phosphate 3-epimerase YP_312310.1 3677029 R 300269 CDS YP_312311.1 74313892 3667364 complement(3677724..3678560) 1 NC_007384.1 Code: L; COG: COG0338; DNA adenine methylase 3678560 dam 3667364 dam Shigella sonnei Ss046 DNA adenine methylase YP_312311.1 3677724 R 300269 CDS YP_312312.1 74313893 3667365 complement(3678667..3679953) 1 NC_007384.1 interferes with cell division; Code: S; COG: COG3266; hypothetical protein 3679953 damX 3667365 damX Shigella sonnei Ss046 hypothetical protein YP_312312.1 3678667 R 300269 CDS YP_312313.1 74313894 3667366 complement(3680045..3681133) 1 NC_007384.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 3681133 aroB 3667366 aroB Shigella sonnei Ss046 3-dehydroquinate synthase YP_312313.1 3680045 R 300269 CDS YP_312314.1 74313895 3667367 complement(3681190..3681711) 1 NC_007384.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 3681711 aroK 3667367 aroK Shigella sonnei Ss046 shikimate kinase I YP_312314.1 3681190 R 300269 CDS YP_312315.1 74313896 3667368 complement(3682112..3683350) 1 NC_007384.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; porin 3683350 hofQ 3667368 hofQ Shigella sonnei Ss046 porin YP_312315.1 3682112 R 300269 CDS YP_312316.1 74313897 3667369 complement(3683262..3683705) 1 NC_007384.1 hypothetical protein 3683705 yrfA 3667369 yrfA Shigella sonnei Ss046 hypothetical protein YP_312316.1 3683262 R 300269 CDS YP_312317.1 74313898 3667233 complement(3683656..3684096) 1 NC_007384.1 hypothetical protein 3684096 yrfB 3667233 yrfB Shigella sonnei Ss046 hypothetical protein YP_312317.1 3683656 R 300269 CDS YP_312318.1 74313899 3667235 complement(3684619..3685425) 1 NC_007384.1 hypothetical protein 3685425 yrfD 3667235 yrfD Shigella sonnei Ss046 hypothetical protein YP_312318.1 3684619 R 300269 CDS YP_312319.2 228861778 3667236 3685518..3688070 1 NC_007384.1 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 3688070 mrcA 3667236 mrcA Shigella sonnei Ss046 peptidoglycan synthetase YP_312319.2 3685518 D 300269 CDS YP_312320.1 74313901 3667237 complement(3688235..3688795) 1 NC_007384.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE 3688795 nudE 3667237 nudE Shigella sonnei Ss046 ADP-ribose diphosphatase NudE YP_312320.1 3688235 R 300269 CDS YP_312321.1 74313902 3667238 3689115..3691250 1 NC_007384.1 dehydrogenase 3691250 yrfF 3667238 yrfF Shigella sonnei Ss046 dehydrogenase YP_312321.1 3689115 D 300269 CDS YP_312322.1 74313903 3667239 3691270..3691983 1 NC_007384.1 Code: R; COG: COG1011; phosphatase 3691983 yrfG 3667239 yrfG Shigella sonnei Ss046 phosphatase YP_312322.1 3691270 D 300269 CDS YP_312323.1 74313904 3667240 3691994..3692395 1 NC_007384.1 Code: J; COG: COG1188; ribosome-associated heat shock protein Hsp15 3692395 yrfH 3667240 yrfH Shigella sonnei Ss046 ribosome-associated heat shock protein Hsp15 YP_312323.1 3691994 D 300269 CDS YP_312324.2 161986433 3667241 3692420..3693298 1 NC_007384.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; heat shock protein 33 3693298 hslO 3667241 hslO Shigella sonnei Ss046 heat shock protein 33 YP_312324.2 3692420 D 300269 CDS YP_312325.1 74313906 3667243 3695512..3697134 1 NC_007384.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 3697134 pckA 3667243 pckA Shigella sonnei Ss046 phosphoenolpyruvate carboxykinase YP_312325.1 3695512 D 300269 CDS YP_312326.1 74313907 3667244 complement(3697210..3698562) 1 NC_007384.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein 3698562 envZ 3667244 envZ Shigella sonnei Ss046 osmolarity sensor protein YP_312326.1 3697210 R 300269 CDS YP_312327.1 74313908 3667245 complement(3698559..3699278) 1 NC_007384.1 sensor; EnvZ; part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator 3699278 ompR 3667245 ompR Shigella sonnei Ss046 osmolarity response regulator YP_312327.1 3698559 R 300269 CDS YP_312328.1 74313909 3667246 3699506..3699982 1 NC_007384.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 3699982 greB 3667246 greB Shigella sonnei Ss046 transcription elongation factor GreB YP_312328.1 3699506 D 300269 CDS YP_312329.1 74313910 3667247 3700178..3702400 1 NC_007384.1 Code: K; COG: COG2183; hypothetical protein 3702400 yhgF 3667247 yhgF Shigella sonnei Ss046 hypothetical protein YP_312329.1 3700178 D 300269 CDS YP_312330.1 74313911 3667248 3702838..3703065 1 NC_007384.1 Code: P; COG: COG1918; ferrous iron transport protein A 3703065 feoA 3667248 feoA Shigella sonnei Ss046 ferrous iron transport protein A YP_312330.1 3702838 D 300269 CDS YP_312331.1 74313912 3667249 3703082..3705403 1 NC_007384.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 3705403 feoB 3667249 feoB Shigella sonnei Ss046 ferrous iron transport protein B YP_312331.1 3703082 D 300269 CDS YP_312332.1 74313913 3667250 3705403..3705639 1 NC_007384.1 hypothetical protein 3705639 yhgG 3667250 yhgG Shigella sonnei Ss046 hypothetical protein YP_312332.1 3705403 D 300269 CDS YP_312333.1 74313914 3667252 complement(3706421..3706924) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3706924 3667252 SSON_3543 Shigella sonnei Ss046 IS1 ORF YP_312333.1 3706421 R 300269 CDS YP_312334.1 74313916 3667137 complement(3707526..3708296) 1 NC_007384.1 reaction prior to pimeloyl CoA; Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH 3708296 bioH 3667137 bioH Shigella sonnei Ss046 carboxylesterase BioH YP_312334.1 3707526 R 300269 CDS YP_312335.2 161986432 3667136 3708334..3709017 1 NC_007384.1 involved in high-affinity gluconate transport; gluconate periplasmic binding protein 3709017 yhgH 3667136 yhgH Shigella sonnei Ss046 gluconate periplasmic binding protein YP_312335.2 3708334 D 300269 CDS YP_312336.1 74313917 3667138 3709076..3709651 1 NC_007384.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; DNA uptake protein 3709651 yhgI 3667138 yhgI Shigella sonnei Ss046 DNA uptake protein YP_312336.1 3709076 D 300269 CDS YP_312337.1 74313918 3667139 3710012..3711328 1 NC_007384.1 Code: GE; COG: COG2610; high-affinity transport permease for gluconate 3711328 gntT 3667139 gntT Shigella sonnei Ss046 high-affinity transport permease for gluconate YP_312337.1 3710012 D 300269 CDS YP_312338.1 74313919 3667140 complement(3711373..3713457) 1 NC_007384.1 amylomaltase; amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 3713457 malQ 3667140 malQ Shigella sonnei Ss046 4-alpha-glucanotransferase YP_312338.1 3711373 R 300269 CDS YP_312339.1 74313920 3667141 complement(3713467..3715860) 1 NC_007384.1 Code: G; COG: COG0058; maltodextrin phosphorylase 3715860 malP 3667141 malP Shigella sonnei Ss046 maltodextrin phosphorylase YP_312339.1 3713467 R 300269 CDS YP_312340.1 74313921 3667142 3716471..3719176 1 NC_007384.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 3719176 malT 3667142 malT Shigella sonnei Ss046 transcriptional regulator MalT YP_312340.1 3716471 D 300269 CDS YP_312341.1 74313922 3667143 complement(3719219..3720238) 1 NC_007384.1 catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase 3720238 yhgKJ 3667143 yhgKJ Shigella sonnei Ss046 RNA 3'-terminal-phosphate cyclase YP_312341.1 3719219 R 300269 CDS YP_312342.1 74313923 3667144 complement(3720239..3721465) 1 NC_007384.1 Code: S; COG: COG1690; hypothetical protein 3721465 rtcB 3667144 rtcB Shigella sonnei Ss046 hypothetical protein YP_312342.1 3720239 R 300269 CDS YP_312343.1 74313924 3667145 complement(3721504..3722007) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3722007 3667145 SSON_3553 Shigella sonnei Ss046 IS1 ORF YP_312343.1 3721504 R 300269 CDS YP_312344.1 74313925 3667146 3722402..3723577 1 NC_007384.1 Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 3723577 yidY 3667146 yidY Shigella sonnei Ss046 multidrug efflux system protein MdtL YP_312344.1 3722402 D 300269 CDS YP_312345.1 74313926 3667147 3723552..3724511 1 NC_007384.1 Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ 3724511 yidZ 3667147 yidZ Shigella sonnei Ss046 DNA-binding transcriptional regulator YidZ YP_312345.1 3723552 D 300269 CDS YP_312346.1 74313927 3667148 3724656..3725417 1 NC_007384.1 Code: H; COG: COG2091; hypothetical protein 3725417 yieE 3667148 yieE Shigella sonnei Ss046 hypothetical protein YP_312346.1 3724656 D 300269 CDS YP_312347.1 74313928 3667150 complement(3726043..3727380) 1 NC_007384.1 Code: R; COG: COG2252; membrane/transport protein 3727380 yieG 3667150 yieG Shigella sonnei Ss046 membrane/transport protein YP_312347.1 3726043 R 300269 CDS YP_312348.1 74313929 3667151 3727546..3728211 1 NC_007384.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 3728211 yieH 3667151 yieH Shigella sonnei Ss046 6-phosphogluconate phosphatase YP_312348.1 3727546 D 300269 CDS YP_312349.1 74313930 3667152 3728278..3728751 1 NC_007384.1 might be involved in hypersensitivity to nitrofurzone; inner membrane protein 3728751 yieI 3667152 yieI Shigella sonnei Ss046 inner membrane protein YP_312349.1 3728278 D 300269 CDS YP_312350.1 74313931 3667153 3729052..3729555 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3729555 3667153 SSON_3561 Shigella sonnei Ss046 IS1 ORF YP_312350.1 3729052 D 300269 CDS YP_312351.1 74313932 3670520 complement(3730368..3730871) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3730871 3670520 SSON_3563 Shigella sonnei Ss046 IS1 ORF YP_312351.1 3730368 R 300269 CDS YP_312352.1 74313933 3670522 complement(3732521..3733159) 1 NC_007384.1 IS4 orf 3733159 3670522 SSON_3565 Shigella sonnei Ss046 IS4 orf YP_312352.1 3732521 R 300269 CDS YP_312353.1 74313934 3670523 complement(3733156..3733866) 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 3733866 3670523 SSON_3566 Shigella sonnei Ss046 IS4 orf YP_312353.1 3733156 R 300269 CDS YP_312354.1 74313935 3670524 complement(3733993..3735642) 1 NC_007384.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 3735642 treF 3670524 treF Shigella sonnei Ss046 trehalase YP_312354.1 3733993 R 300269 CDS YP_312355.1 74313936 3670525 3736047..3737444 1 NC_007384.1 Code: P; COG: COG1858; cytochrome C peroxidase 3737444 yhjA 3670525 yhjA Shigella sonnei Ss046 cytochrome C peroxidase YP_312355.1 3736047 D 300269 CDS YP_312356.1 74313937 3670526 3737655..3739055 1 NC_007384.1 Code: E; COG: COG0076; glutamate decarboxylase 3739055 gadA 3670526 gadA Shigella sonnei Ss046 glutamate decarboxylase YP_312356.1 3737655 D 300269 CDS YP_312357.1 74313938 3670527 3739425..3740249 1 NC_007384.1 regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX 3740249 yhiX 3670527 yhiX Shigella sonnei Ss046 DNA-binding transcriptional regulator GadX YP_312357.1 3739425 D 300269 CDS YP_312358.1 74313939 3670528 3740617..3741345 1 NC_007384.1 Code: K; COG: COG2207; AraC family transcriptional regulator 3741345 yhiW 3670528 yhiW Shigella sonnei Ss046 AraC family transcriptional regulator YP_312358.1 3740617 D 300269 CDS YP_312359.1 74313940 3670529 complement(3741708..3744821) 1 NC_007384.1 Code: V; COG: COG0841; transport system permease 3744821 yhiV 3670529 yhiV Shigella sonnei Ss046 transport system permease YP_312359.1 3741708 R 300269 CDS YP_312360.1 74313941 3670530 complement(3744846..3746003) 1 NC_007384.1 with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds; multidrug efflux system protein MdtE 3746003 yhiU 3670530 yhiU Shigella sonnei Ss046 multidrug efflux system protein MdtE YP_312360.1 3744846 R 300269 CDS YP_312361.1 74313942 3670531 complement(3746342..3746869) 1 NC_007384.1 Code: K; COG: COG2771; hypothetical protein 3746869 yhiE 3670531 yhiE Shigella sonnei Ss046 hypothetical protein YP_312361.1 3746342 R 300269 CDS YP_312362.1 74313943 3670532 complement(3747668..3748240) 1 NC_007384.1 Code: S; COG: COG3247; acid-resistance membrane protein 3748240 hdeD 3670532 hdeD Shigella sonnei Ss046 acid-resistance membrane protein YP_312362.1 3747668 R 300269 CDS YP_312363.1 74313944 3670533 3748495..3748827 1 NC_007384.1 inactive form; acid-resistance protein 3748827 hdeA 3670533 hdeA Shigella sonnei Ss046 acid-resistance protein YP_312363.1 3748495 D 300269 CDS YP_312364.1 74313945 3670534 3748931..3749269 1 NC_007384.1 acid-resistance protein 3749269 hdeB 3670534 hdeB Shigella sonnei Ss046 acid-resistance protein YP_312364.1 3748931 D 300269 CDS YP_312365.1 74313946 3670535 3749333..3749980 1 NC_007384.1 inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli; Mg(2+) transport ATPase 3749980 yhiD 3670535 yhiD Shigella sonnei Ss046 Mg(2+) transport ATPase YP_312365.1 3749333 D 300269 CDS YP_312366.1 74313947 3670536 complement(3750022..3750552) 1 NC_007384.1 Code: K; COG: COG2771; hypothetical protein 3750552 yhiF 3670536 yhiF Shigella sonnei Ss046 hypothetical protein YP_312366.1 3750022 R 300269 CDS YP_312367.1 74313948 3670537 complement(3750708..3751307) 1 NC_007384.1 Code: M; COG: COG3065; outer membrane protein 3751307 slp 3670537 slp Shigella sonnei Ss046 outer membrane protein YP_312367.1 3750708 R 300269 CDS YP_312368.1 74313949 3670538 3751714..3752217 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3752217 3670538 SSON_3581 Shigella sonnei Ss046 IS1 ORF YP_312368.1 3751714 D 300269 CDS YP_312369.1 74313950 3670539 complement(3752676..3753521) 1 NC_007384.1 hypothetical protein 3753521 yhiS 3670539 yhiS Shigella sonnei Ss046 hypothetical protein YP_312369.1 3752676 R 300269 CDS YP_312370.2 161986431 3670501 complement(3753806..3754711) 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3754711 3670501 SSON_3583 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_312370.2 3753806 R 300269 CDS YP_312371.1 74313952 3670502 complement(3754669..3755034) 1 NC_007384.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3755034 3670502 SSON_3584 Shigella sonnei Ss046 insertion sequence 2 OrfA protein YP_312371.1 3754669 R 300269 CDS YP_312372.1 74313953 3670503 complement(3755270..3755983) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 3755983 3670503 SSON_3585 Shigella sonnei Ss046 IS600 ORF2 YP_312372.1 3755270 R 300269 CDS YP_312373.1 74313954 3670504 complement(3756124..3756426) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 3756426 3670504 SSON_3586 Shigella sonnei Ss046 IS600 ORF1 YP_312373.1 3756124 R 300269 CDS YP_312374.1 74313955 3670505 complement(3756689..3757366) 1 NC_007384.1 Code: R; COG: COG0701; hypothetical protein 3757366 3670505 SSON_3587 Shigella sonnei Ss046 hypothetical protein YP_312374.1 3756689 R 300269 CDS YP_312375.1 74313956 3670506 complement(3757490..3758287) 1 NC_007384.1 Code: L; COG: COG1484; IS21 ORF2 3758287 3670506 SSON_3588 Shigella sonnei Ss046 IS21 ORF2 YP_312375.1 3757490 R 300269 CDS YP_312376.1 74313957 3670507 complement(3758338..3759459) 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 3759459 3670507 SSON_3589 Shigella sonnei Ss046 IS21 ORF1 YP_312376.1 3758338 R 300269 CDS YP_312377.1 74313958 3670508 complement(3759541..3760008) 1 NC_007384.1 IS2 ORF2 3760008 3670508 SSON_3590 Shigella sonnei Ss046 IS2 ORF2 YP_312377.1 3759541 R 300269 CDS YP_312378.1 74313959 3670509 complement(3760032..3760397) 1 NC_007384.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3760397 3670509 SSON_3591 Shigella sonnei Ss046 insertion sequence 2 OrfA protein YP_312378.1 3760032 R 300269 CDS YP_312379.1 74313960 3670510 3760645..3760971 1 NC_007384.1 Code: L; COG: COG2963; IS629 ORF1 3760971 3670510 SSON_3592 Shigella sonnei Ss046 IS629 ORF1 YP_312379.1 3760645 D 300269 CDS YP_312380.1 74313961 3670511 3761186..3761452 1 NC_007384.1 IS629 ORF2 3761452 3670511 SSON_3593 Shigella sonnei Ss046 IS629 ORF2 YP_312380.1 3761186 D 300269 CDS YP_312381.1 74313962 3670512 3761468..3761854 1 NC_007384.1 IS629 ORF2 3761854 3670512 SSON_3594 Shigella sonnei Ss046 IS629 ORF2 YP_312381.1 3761468 D 300269 CDS YP_312382.1 74313963 3670514 3762673..3762975 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 3762975 3670514 SSON_3596 Shigella sonnei Ss046 IS600 ORF1 YP_312382.1 3762673 D 300269 CDS YP_312383.1 74313964 3670515 3763116..3763829 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 3763829 3670515 SSON_3597 Shigella sonnei Ss046 IS600 ORF2 YP_312383.1 3763116 D 300269 CDS YP_312384.1 74313965 3670516 complement(3763870..3764754) 1 NC_007384.1 Code: L; COG: COG3547; transposase 3764754 3670516 SSON_3598 Shigella sonnei Ss046 transposase YP_312384.1 3763870 R 300269 CDS YP_312385.1 74313966 3670517 3765345..3765848 1 NC_007384.1 hypothetical protein 3765848 shiE 3670517 shiE Shigella sonnei Ss046 hypothetical protein YP_312385.1 3765345 D 300269 CDS YP_312386.1 74313967 3670518 complement(3766221..3767414) 1 NC_007384.1 Code: GEPR; COG: COG0477; membrane transport protein 3767414 imm 3670518 imm Shigella sonnei Ss046 membrane transport protein YP_312386.1 3766221 R 300269 CDS YP_312387.1 74313968 3670519 3767550..3769274 1 NC_007384.1 siderophore biosynthesis protein 3769274 iucA 3670519 iucA Shigella sonnei Ss046 siderophore biosynthesis protein YP_312387.1 3767550 D 300269 CDS YP_312388.1 74313969 3670426 3769275..3770222 1 NC_007384.1 Code: J; COG: COG1670; siderophore biosynthesis protein 3770222 iucB 3670426 iucB Shigella sonnei Ss046 siderophore biosynthesis protein YP_312388.1 3769275 D 300269 CDS YP_312389.1 74313970 3670427 3770222..3771964 1 NC_007384.1 Code: Q; COG: COG4264; siderophore biosynthesis protein 3771964 iucC 3670427 iucC Shigella sonnei Ss046 siderophore biosynthesis protein YP_312389.1 3770222 D 300269 CDS YP_312390.1 74313971 3670428 3771961..3773298 1 NC_007384.1 Code: Q; COG: COG3486; lysine:N6-hydroxylase 3773298 iucD 3670428 iucD Shigella sonnei Ss046 lysine:N6-hydroxylase YP_312390.1 3771961 D 300269 CDS YP_312391.1 74313972 3670429 3773301..3775499 1 NC_007384.1 Code: P; COG: COG1629; ferric siderophore receptor 3775499 iutA 3670429 iutA Shigella sonnei Ss046 ferric siderophore receptor YP_312391.1 3773301 D 300269 CDS YP_312392.1 74313973 3670430 3776681..3777184 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3777184 3670430 SSON_3606 Shigella sonnei Ss046 IS1 ORF YP_312392.1 3776681 D 300269 CDS YP_312393.1 74313974 3670431 complement(3777811..3778650) 1 NC_007384.1 Code: L; COG: COG2801; IS911 ORF2 3778650 3670431 SSON_3607 Shigella sonnei Ss046 IS911 ORF2 YP_312393.1 3777811 R 300269 CDS YP_312394.1 74313976 3670433 complement(3779250..3780143) 1 NC_007384.1 Code: L; COG: COG2801; IS150 ORF B 3780143 3670433 SSON_3609 Shigella sonnei Ss046 IS150 ORF B YP_312394.1 3779250 R 300269 CDS YP_312395.1 74313975 3670432 3780110..3780385 1 NC_007384.1 Code: L; COG: COG2963; IS629 ORF1 3780385 3670432 SSON_3608 Shigella sonnei Ss046 IS629 ORF1 YP_312395.1 3780110 D 300269 CDS YP_312396.1 74313977 3670434 3780582..3780869 1 NC_007384.1 IS629 ORF2 3780869 3670434 SSON_3610 Shigella sonnei Ss046 IS629 ORF2 YP_312396.1 3780582 D 300269 CDS YP_312397.1 74313978 3670435 3780885..3781091 1 NC_007384.1 IS629 ORF2 3781091 3670435 SSON_3611 Shigella sonnei Ss046 IS629 ORF2 YP_312397.1 3780885 D 300269 CDS YP_312398.1 74313979 3670436 complement(3781106..3781609) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3781609 3670436 SSON_3612 Shigella sonnei Ss046 IS1 ORF YP_312398.1 3781106 R 300269 CDS YP_312399.1 74313980 3670437 complement(3781854..3782621) 1 NC_007384.1 Code: P; COG: COG1464; lipoprotein-28 3782621 nlpA 3670437 nlpA Shigella sonnei Ss046 lipoprotein-28 YP_312399.1 3781854 R 300269 CDS YP_312400.1 74313981 3670438 3782843..3783136 1 NC_007384.1 transporter 3783136 3670438 SSON_3614 Shigella sonnei Ss046 transporter YP_312400.1 3782843 D 300269 CDS YP_312401.2 161986430 3670439 complement(3783260..3784357) 1 NC_007384.1 Code: G; COG: COG2814; transporter 3784357 yicM 3670439 yicM Shigella sonnei Ss046 transporter YP_312401.2 3783260 R 300269 CDS YP_312402.1 74313983 3670440 complement(3784568..3785047) 1 NC_007384.1 hypothetical protein 3785047 yicN 3670440 yicN Shigella sonnei Ss046 hypothetical protein YP_312402.1 3784568 R 300269 CDS YP_312403.1 74313984 3670441 complement(3785971..3786474) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3786474 3670441 SSON_3617 Shigella sonnei Ss046 IS1 ORF YP_312403.1 3785971 R 300269 CDS YP_312404.1 74313985 3670443 3786982..3788748 1 NC_007384.1 xanthine synthesis; catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 3788748 yicP 3670443 yicP Shigella sonnei Ss046 cryptic adenine deaminase YP_312404.1 3786982 D 300269 CDS YP_312405.1 74313986 3670444 complement(3788793..3790184) 1 NC_007384.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter 3790184 uhpT 3670444 uhpT Shigella sonnei Ss046 sugar phosphate antiporter YP_312405.1 3788793 R 300269 CDS YP_312406.1 74313987 3670445 complement(3790322..3791644) 1 NC_007384.1 membrane protein regulates uhpT expression; regulatory protein UhpC 3791644 uhpC 3670445 uhpC Shigella sonnei Ss046 regulatory protein UhpC YP_312406.1 3790322 R 300269 CDS YP_312407.1 74313988 3670387 complement(3791651..3793156) 1 NC_007384.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB 3793156 uhpB 3670387 uhpB Shigella sonnei Ss046 sensory histidine kinase UhpB YP_312407.1 3791651 R 300269 CDS YP_312408.1 74313989 3670388 complement(3793153..3793743) 1 NC_007384.1 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; DNA-binding transcriptional activator UhpA 3793743 uhpA 3670388 uhpA Shigella sonnei Ss046 DNA-binding transcriptional activator UhpA YP_312408.1 3793153 R 300269 CDS YP_312409.1 74313990 3670389 complement(3793818..3794108) 1 NC_007384.1 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit 3794108 ilvN 3670389 ilvN Shigella sonnei Ss046 acetolactate synthase 1 regulatory subunit YP_312409.1 3793818 R 300269 CDS YP_312410.1 74313991 3670390 complement(3794112..3795800) 1 NC_007384.1 Code: EH; COG: COG0028; acetolactate synthase catalytic subunit 3795800 ilvB 3670390 ilvB Shigella sonnei Ss046 acetolactate synthase catalytic subunit YP_312410.1 3794112 R 300269 CDS YP_312411.1 74313992 3670391 complement(3795906..3796004) 1 NC_007384.1 ilvB operon leader peptide 3796004 ivbL 3670391 ivbL Shigella sonnei Ss046 ilvB operon leader peptide YP_312411.1 3795906 R 300269 CDS YP_312412.1 74313993 3670392 3796932..3798122 1 NC_007384.1 multidrug resistance; multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 3798122 emrD 3670392 emrD Shigella sonnei Ss046 multidrug resistance protein D YP_312412.1 3796932 D 300269 CDS YP_312413.1 74313994 3670393 complement(3798130..3798627) 1 NC_007384.1 Code: R; COG: COG0641; transcriptional regulator 3798627 yidF 3670393 yidF Shigella sonnei Ss046 transcriptional regulator YP_312413.1 3798130 R 300269 CDS YP_312414.1 74313995 3670394 complement(3798624..3798986) 1 NC_007384.1 hypothetical protein 3798986 yidG 3670394 yidG Shigella sonnei Ss046 hypothetical protein YP_312414.1 3798624 R 300269 CDS YP_312415.1 74313996 3670395 complement(3798976..3799323) 1 NC_007384.1 Code: S; COG: COG2149; hypothetical protein 3799323 yidH 3670395 yidH Shigella sonnei Ss046 hypothetical protein YP_312415.1 3798976 R 300269 CDS YP_312416.1 74313997 3670396 3799432..3799881 1 NC_007384.1 hypothetical protein 3799881 yidI 3670396 yidI Shigella sonnei Ss046 hypothetical protein YP_312416.1 3799432 D 300269 CDS YP_312417.1 74313998 3670397 complement(3800130..3801278) 1 NC_007384.1 Code: L; COG: COG0675; virulence protein 3801278 3670397 SSON_3632 Shigella sonnei Ss046 virulence protein YP_312417.1 3800130 R 300269 CDS YP_312418.1 74313999 3670399 complement(3803231..3805108) 1 NC_007384.1 Code: G; COG: COG1263; phosphotransferase system enzyme IIBC component 3805108 glvC 3670399 glvC Shigella sonnei Ss046 phosphotransferase system enzyme IIBC component YP_312418.1 3803231 R 300269 CDS YP_312419.1 74314000 3670400 3805143..3805859 1 NC_007384.1 Code: K; COG: COG2188; transcriptional regulator 3805859 yidP 3670400 yidP Shigella sonnei Ss046 transcriptional regulator YP_312419.1 3805143 D 300269 CDS YP_312420.2 161986429 3670401 complement(3805856..3807517) 1 NC_007384.1 Code: R; COG: COG2985; hypothetical protein 3807517 yidE 3670401 yidE Shigella sonnei Ss046 hypothetical protein YP_312420.2 3805856 R 300269 CDS YP_312421.2 161986428 3670402 complement(3807713..3808141) 1 NC_007384.1 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB 3808141 ibpB 3670402 ibpB Shigella sonnei Ss046 heat shock chaperone IbpB YP_312421.2 3807713 R 300269 CDS YP_312422.1 74314003 3670403 complement(3808253..3808666) 1 NC_007384.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA 3808666 ibpA 3670403 ibpA Shigella sonnei Ss046 heat shock protein IbpA YP_312422.1 3808253 R 300269 CDS YP_312423.2 161986427 3670404 3808972..3809304 1 NC_007384.1 Code: R; COG: COG5645; hypothetical protein 3809304 yidQ 3670404 yidQ Shigella sonnei Ss046 hypothetical protein YP_312423.2 3808972 D 300269 CDS YP_312424.1 74314005 3670405 complement(3809306..3810556) 1 NC_007384.1 hypothetical protein 3810556 yidR 3670405 yidR Shigella sonnei Ss046 hypothetical protein YP_312424.1 3809306 R 300269 CDS YP_312425.2 161986426 3670367 3810621..3811685 1 NC_007384.1 FAD/NAD(P)-binding domain; oxidoreductase 3811685 yidS 3670367 yidS Shigella sonnei Ss046 oxidoreductase YP_312425.2 3810621 D 300269 CDS YP_312426.1 74314007 3670368 complement(3811682..3813019) 1 NC_007384.1 Code: GEPR; COG: COG0477; D-galactonate transport 3813019 dgoT 3670368 dgoT Shigella sonnei Ss046 D-galactonate transport YP_312426.1 3811682 R 300269 CDS YP_312427.1 74314008 3670370 complement(3814840..3815718) 1 NC_007384.1 Code: G; COG: COG3734; 2-oxo-3-deoxygalactonate kinase 3815718 dgoK 3670370 dgoK Shigella sonnei Ss046 2-oxo-3-deoxygalactonate kinase YP_312427.1 3814840 R 300269 CDS YP_312428.1 74314009 3670371 complement(3815715..3816011) 1 NC_007384.1 Code: K; COG: COG2186; FadA-type transcriptional regulator 3816011 3670371 SSON_3645 Shigella sonnei Ss046 FadA-type transcriptional regulator YP_312428.1 3815715 R 300269 CDS YP_312429.1 74314010 3670372 3816598..3817005 1 NC_007384.1 hypothetical protein 3817005 3670372 SSON_3646 Shigella sonnei Ss046 hypothetical protein YP_312429.1 3816598 D 300269 CDS YP_312430.1 74314011 3670373 complement(3817051..3817863) 1 NC_007384.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase 3817863 yidA 3670373 yidA Shigella sonnei Ss046 sugar phosphatase YP_312430.1 3817051 R 300269 CDS YP_312431.1 74314012 3670374 complement(3817978..3818385) 1 NC_007384.1 Code: S; COG: COG3753; hypothetical protein 3818385 yidB 3670374 yidB Shigella sonnei Ss046 hypothetical protein YP_312431.1 3817978 R 300269 CDS YP_312432.1 74314013 3670375 complement(3818616..3821030) 1 NC_007384.1 type II topoisomerase; ATPase activity; negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 3821030 gyrB 3670375 gyrB Shigella sonnei Ss046 DNA gyrase subunit B YP_312432.1 3818616 R 300269 CDS YP_312433.1 74314014 3670376 complement(3821059..3822132) 1 NC_007384.1 ATP binding; Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 3822132 recF 3670376 recF Shigella sonnei Ss046 recombination protein F YP_312433.1 3821059 R 300269 CDS YP_312434.1 74314015 3670377 complement(3822132..3823232) 1 NC_007384.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 3823232 dnaN 3670377 dnaN Shigella sonnei Ss046 DNA polymerase III subunit beta YP_312434.1 3822132 R 300269 CDS YP_312435.1 74314016 3670378 complement(3823237..3824640) 1 NC_007384.1 DNA biosynthesis; initiation of chromosome replication; can be transcription regulator; binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself; chromosome replication initiator DnaA 3824640 dnaA 3670378 dnaA Shigella sonnei Ss046 chromosome replication initiator DnaA YP_312435.1 3823237 R 300269 CDS YP_312436.1 74314017 3670379 3825247..3825387 1 NC_007384.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 3825387 rpmH 3670379 rpmH Shigella sonnei Ss046 50S ribosomal protein L34 YP_312436.1 3825247 D 300269 CDS YP_312437.1 74314018 3670380 3825404..3825763 1 NC_007384.1 protein C5; processes tRNA; 4.5S RNA; protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 3825763 rnpA 3670380 rnpA Shigella sonnei Ss046 ribonuclease P YP_312437.1 3825404 D 300269 CDS YP_312438.1 74314019 3670381 3825727..3825984 1 NC_007384.1 Code: S; COG: COG0759; hypothetical protein 3825984 yidD 3670381 yidD Shigella sonnei Ss046 hypothetical protein YP_312438.1 3825727 D 300269 CDS YP_312439.1 74314020 3670382 3825987..3827633 1 NC_007384.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 3827633 yidC 3670382 yidC Shigella sonnei Ss046 inner membrane protein translocase component YidC YP_312439.1 3825987 D 300269 CDS YP_312440.1 74314021 3670383 3827739..3829103 1 NC_007384.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 3829103 trmE 3670383 trmE Shigella sonnei Ss046 tRNA modification GTPase TrmE YP_312440.1 3827739 D 300269 CDS YP_312441.1 74314022 3670384 complement(3829268..3829771) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3829771 3670384 SSON_3658 Shigella sonnei Ss046 IS1 ORF YP_312441.1 3829268 R 300269 CDS YP_312442.1 74314023 3670386 complement(3831775..3832533) 1 NC_007384.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR 3832533 glpR 3670386 glpR Shigella sonnei Ss046 DNA-binding transcriptional repressor GlpR YP_312442.1 3831775 R 300269 CDS YP_312443.1 74314024 3670348 complement(3832550..3833380) 1 NC_007384.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG 3833380 glpG 3670348 glpG Shigella sonnei Ss046 intramembrane serine protease GlpG YP_312443.1 3832550 R 300269 CDS YP_312444.1 74314025 3670349 complement(3833425..3833751) 1 NC_007384.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase 3833751 glpE 3670349 glpE Shigella sonnei Ss046 thiosulfate sulfurtransferase YP_312444.1 3833425 R 300269 CDS YP_312445.1 74314026 3670350 3833941..3835446 1 NC_007384.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 3835446 glpD 3670350 glpD Shigella sonnei Ss046 glycerol-3-phosphate dehydrogenase YP_312445.1 3833941 D 300269 CDS YP_312446.1 74314027 3670351 complement(3836106..3836873) 1 NC_007384.1 hypothetical protein 3836873 3670351 SSON_3664 Shigella sonnei Ss046 hypothetical protein YP_312446.1 3836106 R 300269 CDS YP_312447.1 74314028 3670352 complement(3836876..3837586) 1 NC_007384.1 hypothetical protein 3837586 3670352 SSON_3665 Shigella sonnei Ss046 hypothetical protein YP_312447.1 3836876 R 300269 CDS YP_312448.1 74314029 3670353 complement(3837602..3839107) 1 NC_007384.1 Code: P; COG: COG0226; hypothetical protein 3839107 3670353 SSON_3666 Shigella sonnei Ss046 hypothetical protein YP_312448.1 3837602 R 300269 CDS YP_312449.1 74314030 3670354 3839281..3840627 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 3840627 3670354 SSON_3667 Shigella sonnei Ss046 IS4 orf YP_312449.1 3839281 D 300269 CDS YP_312450.1 74314031 3670355 complement(3840674..3843121) 1 NC_007384.1 Code: G; COG: COG0058; glycogen phosphorylase 3843121 glgP 3670355 glgP Shigella sonnei Ss046 glycogen phosphorylase YP_312450.1 3840674 R 300269 CDS YP_312451.1 74314032 3670356 complement(3843140..3844573) 1 NC_007384.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 3844573 glgA 3670356 glgA Shigella sonnei Ss046 glycogen synthase YP_312451.1 3843140 R 300269 CDS YP_312452.1 74314033 3670357 complement(3844573..3845868) 1 NC_007384.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 3845868 glgC 3670357 glgC Shigella sonnei Ss046 glucose-1-phosphate adenylyltransferase YP_312452.1 3844573 R 300269 CDS YP_312453.1 74314034 3670358 complement(3845886..3847859) 1 NC_007384.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching protein 3847859 glgX 3670358 glgX Shigella sonnei Ss046 glycogen debranching protein YP_312453.1 3845886 R 300269 CDS YP_312454.1 74314035 3670359 complement(3847856..3850042) 1 NC_007384.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 3850042 glgB 3670359 glgB Shigella sonnei Ss046 glycogen branching protein YP_312454.1 3847856 R 300269 CDS YP_312455.1 74314036 3670360 complement(3850315..3851418) 1 NC_007384.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 3851418 asd 3670360 asd Shigella sonnei Ss046 aspartate-semialdehyde dehydrogenase YP_312455.1 3850315 R 300269 CDS YP_312456.1 74314037 3670361 3851610..3852203 1 NC_007384.1 YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); dITP- and XTP- hydrolase 3852203 yhgN 3670361 yhgN Shigella sonnei Ss046 dITP- and XTP- hydrolase YP_312456.1 3851610 D 300269 CDS YP_312457.1 74314038 3670362 complement(3852249..3853544) 1 NC_007384.1 Code: LU; COG: COG0758; DNA processing protein 3853544 3670362 SSON_3675 Shigella sonnei Ss046 DNA processing protein YP_312457.1 3852249 R 300269 CDS YP_312458.1 74314039 3670363 complement(3853661..3854164) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3854164 3670363 SSON_3676 Shigella sonnei Ss046 IS1 ORF YP_312458.1 3853661 R 300269 CDS YP_312459.1 74314040 3670364 complement(3854387..3856198) 1 NC_007384.1 Code: L; COG: COG0514; hypothetical protein 3856198 3670364 SSON_3677 Shigella sonnei Ss046 hypothetical protein YP_312459.1 3854387 R 300269 CDS YP_312460.1 74314041 3670365 complement(3856339..3857679) 1 NC_007384.1 Code: GE; COG: COG2610; low affinity gluconate transporter 3857679 gntU 3670365 gntU Shigella sonnei Ss046 low affinity gluconate transporter YP_312460.1 3856339 R 300269 CDS YP_312461.2 161986425 3670366 complement(3857683..3858210) 1 NC_007384.1 thermoresistant; thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase 3858210 gntK 3670366 gntK Shigella sonnei Ss046 gluconate kinase YP_312461.2 3857683 R 300269 CDS YP_312462.1 74314043 3670271 complement(3858349..3859287) 1 NC_007384.1 Code: K; COG: COG1609; gluconate (gnt) operon regulator 3859287 gntR 3670271 gntR Shigella sonnei Ss046 gluconate (gnt) operon regulator YP_312462.1 3858349 R 300269 CDS YP_312463.1 74314044 3670272 complement(3859568..3860263) 1 NC_007384.1 Code: R; COG: COG1741; hypothetical protein 3860263 yhhW 3670272 yhhW Shigella sonnei Ss046 hypothetical protein YP_312463.1 3859568 R 300269 CDS YP_312464.1 74314045 3670273 complement(3860386..3861423) 1 NC_007384.1 Code: R; COG: COG0673; dehydrogenase 3861423 yhhX 3670273 yhhX Shigella sonnei Ss046 dehydrogenase YP_312464.1 3860386 R 300269 CDS YP_312465.1 74314046 3670274 3861664..3862221 1 NC_007384.1 YhhY; regulated by the fur regulator; unknown function; acetyltransferase YhhY 3862221 yhhY 3670274 yhhY Shigella sonnei Ss046 acetyltransferase YhhY YP_312465.1 3861664 D 300269 CDS YP_312466.1 74314047 3670275 3862449..3862952 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3862952 3670275 SSON_3684 Shigella sonnei Ss046 IS1 ORF YP_312466.1 3862449 D 300269 CDS YP_312467.1 74314048 3670276 complement(3862946..3864445) 1 NC_007384.1 Code: E; COG: COG0405; gamma-glutamyltranspeptidase 3864445 ggt 3670276 ggt Shigella sonnei Ss046 gamma-glutamyltranspeptidase YP_312467.1 3862946 R 300269 CDS YP_312468.1 74314049 3670277 3864565..3865005 1 NC_007384.1 hypothetical protein 3865005 yhhA 3670277 yhhA Shigella sonnei Ss046 hypothetical protein YP_312468.1 3864565 D 300269 CDS YP_312469.1 74314050 3670278 complement(3864992..3865735) 1 NC_007384.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; glycerophosphodiester phosphodiesterase 3865735 ugpQ 3670278 ugpQ Shigella sonnei Ss046 glycerophosphodiester phosphodiesterase YP_312469.1 3864992 R 300269 CDS YP_312470.2 161986424 3670279 complement(3865732..3866802) 1 NC_007384.1 part of the UgpABCE glycerol-3-phosphate uptake system; glycerol-3-phosphate transporter ATP-binding subunit 3866802 ugpC 3670279 ugpC Shigella sonnei Ss046 glycerol-3-phosphate transporter ATP-binding subunit YP_312470.2 3865732 R 300269 CDS YP_312471.1 74314052 3670280 complement(3866804..3867649) 1 NC_007384.1 integral membrane protein; with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein 3867649 ugpE 3670280 ugpE Shigella sonnei Ss046 glycerol-3-phosphate transporter membrane protein YP_312471.1 3866804 R 300269 CDS YP_312472.1 74314053 3670281 complement(3867646..3868533) 1 NC_007384.1 with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease 3868533 ugpA 3670281 ugpA Shigella sonnei Ss046 glycerol-3-phosphate transporter permease YP_312472.1 3867646 R 300269 CDS YP_312473.2 161986423 3670283 complement(3869979..3870692) 1 NC_007384.1 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 3870692 livF 3670283 livF Shigella sonnei Ss046 leucine/isoleucine/valine transporter ATP-binding subunit YP_312473.2 3869979 R 300269 CDS YP_312474.1 74314055 3670284 complement(3870694..3871461) 1 NC_007384.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 3871461 livG 3670284 livG Shigella sonnei Ss046 leucine/isoleucine/valine transporter ATP-binding subunit YP_312474.1 3870694 R 300269 CDS YP_312475.1 74314056 3670285 complement(3871458..3872735) 1 NC_007384.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease subunit 3872735 livM 3670285 livM Shigella sonnei Ss046 leucine/isoleucine/valine transporter permease subunit YP_312475.1 3871458 R 300269 CDS YP_312476.1 74314057 3670286 complement(3872732..3873658) 1 NC_007384.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid transporter permease subunit LivH 3873658 livH 3670286 livH Shigella sonnei Ss046 branched-chain amino acid transporter permease subunit LivH YP_312476.1 3872732 R 300269 CDS YP_312477.1 74314058 3670287 complement(3873706..3874815) 1 NC_007384.1 Code: E; COG: COG0683; high-affinity leucine-specific transport system periplasmic binding protein 3874815 livK 3670287 livK Shigella sonnei Ss046 high-affinity leucine-specific transport system periplasmic binding protein YP_312477.1 3873706 R 300269 CDS YP_312478.1 74314059 3670288 3875239..3875622 1 NC_007384.1 hypothetical protein 3875622 yhhK 3670288 yhhK Shigella sonnei Ss046 hypothetical protein YP_312478.1 3875239 D 300269 CDS YP_312479.1 74314060 3670289 complement(3875821..3876981) 1 NC_007384.1 Code: E; COG: COG0683; high-affinity amino acid transport system periplasmic binding protein 3876981 livJ 3670289 livJ Shigella sonnei Ss046 high-affinity amino acid transport system periplasmic binding protein YP_312479.1 3875821 R 300269 CDS YP_312480.1 74314061 3670290 complement(3877195..3878049) 1 NC_007384.1 regulation of proteins induced at high temperatures; binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 3878049 rpoH 3670290 rpoH Shigella sonnei Ss046 RNA polymerase factor sigma-32 YP_312480.1 3877195 R 300269 CDS YP_312481.1 74314062 3670233 complement(3878294..3879352) 1 NC_007384.1 ABC transporter, membrane protein; cell division protein FtsX 3879352 ftsX 3670233 ftsX Shigella sonnei Ss046 cell division protein FtsX YP_312481.1 3878294 R 300269 CDS YP_312482.1 74314063 3670234 complement(3879345..3880013) 1 NC_007384.1 ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE 3880013 ftsE 3670234 ftsE Shigella sonnei Ss046 cell division protein FtsE YP_312482.1 3879345 R 300269 CDS YP_312483.1 74314064 3670235 complement(3880016..3881512) 1 NC_007384.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY 3881512 ftsY 3670235 ftsY Shigella sonnei Ss046 cell division protein FtsY YP_312483.1 3880016 R 300269 CDS YP_312484.1 74314065 3670236 3881662..3882258 1 NC_007384.1 catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 3882258 rsmD 3670236 rsmD Shigella sonnei Ss046 16S rRNA m(2)G966-methyltransferase YP_312484.1 3881662 D 300269 CDS YP_312485.1 74314066 3670237 3882248..3882517 1 NC_007384.1 Code: S; COG: COG3776; hypothetical protein 3882517 yhhL 3670237 yhhL Shigella sonnei Ss046 hypothetical protein YP_312485.1 3882248 D 300269 CDS YP_312486.1 74314067 3670238 complement(3882520..3882879) 1 NC_007384.1 receptor 3882879 yhhM 3670238 yhhM Shigella sonnei Ss046 receptor YP_312486.1 3882520 R 300269 CDS YP_312487.1 74314068 3670239 3883020..3883646 1 NC_007384.1 Code: S; COG: COG3714; hypothetical protein 3883646 yhhN 3670239 yhhN Shigella sonnei Ss046 hypothetical protein YP_312487.1 3883020 D 300269 CDS YP_312488.1 74314069 3670240 3883720..3885918 1 NC_007384.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 3885918 zntA 3670240 zntA Shigella sonnei Ss046 zinc/cadmium/mercury/lead-transporting ATPase YP_312488.1 3883720 D 300269 CDS YP_312489.1 74314070 3670241 complement(3886020..3886265) 1 NC_007384.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 3886265 yhhP 3670241 yhhP Shigella sonnei Ss046 sulfur transfer protein SirA YP_312489.1 3886020 R 300269 CDS YP_312490.1 74314071 3670242 3886486..3887151 1 NC_007384.1 Code: S; COG: COG1738; hypothetical protein 3887151 yhhQ 3670242 yhhQ Shigella sonnei Ss046 hypothetical protein YP_312490.1 3886486 D 300269 CDS YP_312491.2 161986422 3670243 3887224..3887781 1 NC_007384.1 hypothetical protein 3887781 3670243 SSON_3710 Shigella sonnei Ss046 hypothetical protein YP_312491.2 3887224 D 300269 CDS YP_312492.2 161986421 3670244 complement(3887785..3889002) 1 NC_007384.1 Code: GEPR; COG: COG0477; major facilitator superfamily transporter 3889002 yhhS 3670244 yhhS Shigella sonnei Ss046 major facilitator superfamily transporter YP_312492.2 3887785 R 300269 CDS YP_312493.1 74314074 3670245 3889053..3890183 1 NC_007384.1 Code: R; COG: COG0628; hypothetical protein 3890183 yhhT 3670245 yhhT Shigella sonnei Ss046 hypothetical protein YP_312493.1 3889053 D 300269 CDS YP_312494.1 74314075 3670246 3890238..3890825 1 NC_007384.1 Code: H; COG: COG2091; holo-(acyl carrier protein) synthase 2 3890825 yhhU 3670246 yhhU Shigella sonnei Ss046 holo-(acyl carrier protein) synthase 2 YP_312494.1 3890238 D 300269 CDS YP_312495.1 74314076 3670247 3890936..3892510 1 NC_007384.1 Code: E; COG: COG0747; periplasmic binding protein for nickel 3892510 nikA 3670247 nikA Shigella sonnei Ss046 periplasmic binding protein for nickel YP_312495.1 3890936 D 300269 CDS YP_312496.1 74314077 3670248 3892510..3893454 1 NC_007384.1 with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 3893454 nikB 3670248 nikB Shigella sonnei Ss046 nickel transporter permease NikB YP_312496.1 3892510 D 300269 CDS YP_312497.1 74314078 3670249 3893451..3894284 1 NC_007384.1 with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 3894284 nikC 3670249 nikC Shigella sonnei Ss046 nickel transporter permease NikC YP_312497.1 3893451 D 300269 CDS YP_312498.1 74314079 3670250 3894284..3895048 1 NC_007384.1 with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 3895048 nikD 3670250 nikD Shigella sonnei Ss046 nickel transporter ATP-binding protein NikD YP_312498.1 3894284 D 300269 CDS YP_312499.1 74314080 3670251 3895045..3895851 1 NC_007384.1 with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 3895851 nikE 3670251 nikE Shigella sonnei Ss046 nickel transporter ATP-binding protein NikE YP_312499.1 3895045 D 300269 CDS YP_312500.1 74314081 3670213 3895857..3896258 1 NC_007384.1 Inhibits transcription at high concentrations of nickel; nickel responsive regulator 3896258 yhhG 3670213 yhhG Shigella sonnei Ss046 nickel responsive regulator YP_312500.1 3895857 D 300269 CDS YP_312501.1 74314082 3670214 complement(3896378..3896737) 1 NC_007384.1 Code: S; COG: COG4226; hypothetical protein 3896737 hicB 3670214 hicB Shigella sonnei Ss046 hypothetical protein YP_312501.1 3896378 R 300269 CDS YP_312502.1 74314083 3670215 complement(3897080..3898207) 1 NC_007384.1 Code: V; COG: COG0842; transporter 3898207 yhhJ 3670215 yhhJ Shigella sonnei Ss046 transporter YP_312502.1 3897080 R 300269 CDS YP_312503.1 74314084 3670216 complement(3898204..3900888) 1 NC_007384.1 Code: V; COG: COG1131; ABC transporter ATP-binding protein, fragment 1 3900888 yhiH 3670216 yhiH Shigella sonnei Ss046 ABC transporter ATP-binding protein, fragment 1 YP_312503.1 3898204 R 300269 CDS YP_312504.1 74314085 3670217 complement(3900936..3902003) 1 NC_007384.1 Code: M; COG: COG0845; hypothetical protein 3902003 yhiI 3670217 yhiI Shigella sonnei Ss046 hypothetical protein YP_312504.1 3900936 R 300269 CDS YP_312505.1 74314086 3670218 complement(3902369..3903991) 1 NC_007384.1 hypothetical protein 3903991 yhiJ 3670218 yhiJ Shigella sonnei Ss046 hypothetical protein YP_312505.1 3902369 R 300269 CDS YP_312506.1 74314087 3670219 complement(3904253..3905860) 1 NC_007384.1 hypothetical protein 3905860 yhiL 3670219 yhiL Shigella sonnei Ss046 hypothetical protein YP_312506.1 3904253 R 300269 CDS YP_312507.1 74314088 3670220 3906269..3907243 1 NC_007384.1 hypothetical protein 3907243 yhiM 3670220 yhiM Shigella sonnei Ss046 hypothetical protein YP_312507.1 3906269 D 300269 CDS YP_312508.1 74314089 3670221 complement(3907559..3908761) 1 NC_007384.1 Code: R; COG: COG2081; hypothetical protein 3908761 yhiN 3670221 yhiN Shigella sonnei Ss046 hypothetical protein YP_312508.1 3907559 R 300269 CDS YP_312509.1 74314090 3670222 3908993..3910492 1 NC_007384.1 Code: P; COG: COG0306; low-affinity phosphate transport protein 3910492 pitA 3670222 pitA Shigella sonnei Ss046 low-affinity phosphate transport protein YP_312509.1 3908993 D 300269 CDS YP_312510.1 74314091 3670223 complement(3910736..3911071) 1 NC_007384.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB 3911071 yhiO 3670223 yhiO Shigella sonnei Ss046 universal stress protein UspB YP_312510.1 3910736 R 300269 CDS YP_312511.1 74314092 3670224 3911462..3911896 1 NC_007384.1 possible broad regulatory function; Code: T; COG: COG0589; universal stress protein 3911896 uspA 3670224 uspA Shigella sonnei Ss046 universal stress protein YP_312511.1 3911462 D 300269 CDS YP_312512.1 74314093 3670225 3912214..3913683 1 NC_007384.1 member of the POT family of peptide transporters; probable proton-dependent peptide transporter function; inner membrane transporter YhiP 3913683 yhiP 3670225 yhiP Shigella sonnei Ss046 inner membrane transporter YhiP YP_312512.1 3912214 D 300269 CDS YP_312513.1 74314094 3670226 complement(3913732..3914484) 1 NC_007384.1 predicted SAM-dependent methyltransferase; methyltransferase 3914484 yhiQ 3670226 yhiQ Shigella sonnei Ss046 methyltransferase YP_312513.1 3913732 R 300269 CDS YP_312514.1 74314095 3670227 complement(3914492..3916534) 1 NC_007384.1 Code: E; COG: COG0339; oligopeptidase A 3916534 prlC 3670227 prlC Shigella sonnei Ss046 oligopeptidase A YP_312514.1 3914492 R 300269 CDS YP_312515.1 74314096 3670228 3916737..3917579 1 NC_007384.1 Code: R; COG: COG2961; hypothetical protein 3917579 yhiR 3670228 yhiR Shigella sonnei Ss046 hypothetical protein YP_312515.1 3916737 D 300269 CDS YP_312516.1 74314097 3670229 3917651..3919003 1 NC_007384.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 3919003 gor 3670229 gor Shigella sonnei Ss046 glutathione reductase YP_312516.1 3917651 D 300269 CDS YP_312517.1 74314098 3670230 3919880..3920233 1 NC_007384.1 regulates the expression of of the arsRBC involved in resistance to arsenic; DNA-binding transcriptional repressor ArsR 3920233 arsR 3670230 arsR Shigella sonnei Ss046 DNA-binding transcriptional repressor ArsR YP_312517.1 3919880 D 300269 CDS YP_312518.1 74314099 3670231 3920266..3921576 1 NC_007384.1 Code: P; COG: COG1055; arsenical pump membrane protein 3921576 arsB 3670231 arsB Shigella sonnei Ss046 arsenical pump membrane protein YP_312518.1 3920266 D 300269 CDS YP_312519.1 74314100 3670232 3921589..3922014 1 NC_007384.1 Code: P; COG: COG1393; arsenate reductase 3922014 arsC 3670232 arsC Shigella sonnei Ss046 arsenate reductase YP_312519.1 3921589 D 300269 CDS YP_312520.1 74314101 3670195 complement(3922148..3922444) 1 NC_007384.1 Code: K; COG: COG0640; hypothetical protein 3922444 3670195 SSON_3739 Shigella sonnei Ss046 hypothetical protein YP_312520.1 3922148 R 300269 CDS YP_312521.1 74314102 3670196 3922916..3924088 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 3924088 3670196 SSON_3740 Shigella sonnei Ss046 IS21 ORF1 YP_312521.1 3922916 D 300269 CDS YP_312522.1 74314103 3670197 3924088..3924885 1 NC_007384.1 Code: L; COG: COG1484; IS21 ORF2 3924885 3670197 SSON_3741 Shigella sonnei Ss046 IS21 ORF2 YP_312522.1 3924088 D 300269 CDS YP_312523.1 74314104 3670198 3924972..3925340 1 NC_007384.1 IS2 ORF2 3925340 3670198 SSON_3742 Shigella sonnei Ss046 IS2 ORF2 YP_312523.1 3924972 D 300269 CDS YP_312524.1 74314105 3670199 complement(3925632..3926579) 1 NC_007384.1 hypothetical protein 3926579 3670199 SSON_3743 Shigella sonnei Ss046 hypothetical protein YP_312524.1 3925632 R 300269 CDS YP_312525.1 74314106 3670200 complement(3927087..3928271) 1 NC_007384.1 Code: L; COG: COG0582; integrase 3928271 3670200 SSON_3744 Shigella sonnei Ss046 integrase YP_312525.1 3927087 R 300269 CDS YP_312526.1 74314107 3670202 3928958..3930181 1 NC_007384.1 Code: G; COG: COG2211; permease 3930181 yicJ 3670202 yicJ Shigella sonnei Ss046 permease YP_312526.1 3928958 D 300269 CDS YP_312527.1 74314108 3670203 3930409..3930912 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3930912 3670203 SSON_3747 Shigella sonnei Ss046 IS1 ORF YP_312527.1 3930409 D 300269 CDS YP_312528.1 74314109 3670205 3932345..3933691 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 3933691 3670205 SSON_3749 Shigella sonnei Ss046 IS4 orf YP_312528.1 3932345 D 300269 CDS YP_312529.1 74314110 3670206 complement(3934935..3936644) 1 NC_007384.1 hypothetical protein 3936644 yicH 3670206 yicH Shigella sonnei Ss046 hypothetical protein YP_312529.1 3934935 R 300269 CDS YP_312530.1 74314111 3670207 complement(3936765..3938156) 1 NC_007384.1 Code: F; COG: COG2233; transporter 3938156 yicE 3670207 yicE Shigella sonnei Ss046 transporter YP_312530.1 3936765 R 300269 CDS YP_312531.1 74314112 3670208 3938436..3939641 1 NC_007384.1 Code: E; COG: COG0786; glutamate transport 3939641 gltS 3670208 gltS Shigella sonnei Ss046 glutamate transport YP_312531.1 3938436 D 300269 CDS YP_312532.1 74314113 3670209 complement(3939810..3941891) 1 NC_007384.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 3941891 recG 3670209 recG Shigella sonnei Ss046 ATP-dependent DNA helicase RecG YP_312532.1 3939810 R 300269 CDS YP_312533.1 74314114 3670210 complement(3941897..3942586) 1 NC_007384.1 specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 3942586 spoU 3670210 spoU Shigella sonnei Ss046 tRNA guanosine-2'-O-methyltransferase YP_312533.1 3941897 R 300269 CDS YP_312534.1 74314115 3670211 complement(3942593..3944701) 1 NC_007384.1 also guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Code: TK; COG: COG0317; bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 3944701 spoT 3670211 spoT Shigella sonnei Ss046 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase YP_312534.1 3942593 R 300269 CDS YP_312535.1 74314116 3670212 complement(3944720..3944995) 1 NC_007384.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 3944995 rpoZ 3670212 rpoZ Shigella sonnei Ss046 DNA-directed RNA polymerase subunit omega YP_312535.1 3944720 R 300269 CDS YP_312536.1 74314117 3670116 complement(3945050..3945673) 1 NC_007384.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 3945673 gmk 3670116 gmk Shigella sonnei Ss046 guanylate kinase YP_312536.1 3945050 R 300269 CDS YP_312537.1 74314118 3670117 3945807..3946070 1 NC_007384.1 hypothetical protein 3946070 3670117 SSON_3758 Shigella sonnei Ss046 hypothetical protein YP_312537.1 3945807 D 300269 CDS YP_312538.1 74314119 3670118 3945925..3947613 1 NC_007384.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB 3947613 ligB 3670118 ligB Shigella sonnei Ss046 NAD-dependent DNA ligase LigB YP_312538.1 3945925 D 300269 CDS YP_312539.1 74314120 3670119 complement(3947610..3948281) 1 NC_007384.1 Code: S; COG: COG2860; hypothetical protein 3948281 yicG 3670119 yicG Shigella sonnei Ss046 hypothetical protein YP_312539.1 3947610 R 300269 CDS YP_312540.2 161986420 3670120 complement(3948519..3949343) 1 NC_007384.1 DNA-damage-inducible protein D 3949343 dinD 3670120 dinD Shigella sonnei Ss046 DNA-damage-inducible protein D YP_312540.2 3948519 R 300269 CDS YP_312541.1 74314122 3670121 complement(3949565..3950428) 1 NC_007384.1 Code: S; COG: COG1561; hypothetical protein 3950428 yicC 3670121 yicC Shigella sonnei Ss046 hypothetical protein YP_312541.1 3949565 R 300269 CDS YP_312542.1 74314123 3670122 3950555..3951271 1 NC_007384.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 3951271 rph 3670122 rph Shigella sonnei Ss046 ribonuclease PH YP_312542.1 3950555 D 300269 CDS YP_312543.1 74314124 3670123 3951337..3951978 1 NC_007384.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 3951978 pyrE 3670123 pyrE Shigella sonnei Ss046 orotate phosphoribosyltransferase YP_312543.1 3951337 D 300269 CDS YP_312544.2 161986419 3670124 complement(3952015..3952611) 1 NC_007384.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 3952611 slmA 3670124 slmA Shigella sonnei Ss046 nucleoid occlusion protein YP_312544.2 3952015 R 300269 CDS YP_312545.1 74314126 3670125 complement(3952718..3953173) 1 NC_007384.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 3953173 dut 3670125 dut Shigella sonnei Ss046 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_312545.1 3952718 R 300269 CDS YP_312546.2 161986418 3670126 complement(3953154..3954374) 1 NC_007384.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 3954374 dfp 3670126 dfp Shigella sonnei Ss046 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_312546.2 3953154 R 300269 CDS YP_312547.1 74314128 3670128 3954971..3955474 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3955474 3670128 SSON_3769 Shigella sonnei Ss046 IS1 ORF YP_312547.1 3954971 D 300269 CDS YP_312548.1 74314129 3670129 3956208..3956444 1 NC_007384.1 required for 70S ribosome assembly; 50S ribosomal protein L28 3956444 rpmB 3670129 rpmB Shigella sonnei Ss046 50S ribosomal protein L28 YP_312548.1 3956208 D 300269 CDS YP_312549.1 74314130 3670130 3956465..3956632 1 NC_007384.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 3956632 rpmG 3670130 rpmG Shigella sonnei Ss046 50S ribosomal protein L33 YP_312549.1 3956465 D 300269 CDS YP_312550.1 74314131 3670131 3956730..3957539 1 NC_007384.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 3957539 mutM 3670131 mutM Shigella sonnei Ss046 formamidopyrimidine-DNA glycosylase YP_312550.1 3956730 D 300269 CDS YP_312551.1 74314132 3670132 complement(3957578..3958057) 1 NC_007384.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 3958057 coaD 3670132 coaD Shigella sonnei Ss046 phosphopantetheine adenylyltransferase YP_312551.1 3957578 R 300269 CDS YP_312552.1 74314133 3670133 complement(3958065..3959342) 1 NC_007384.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 3959342 kdtA 3670133 kdtA Shigella sonnei Ss046 3-deoxy-D-manno-octulosonic-acid transferase YP_312552.1 3958065 R 300269 CDS YP_312553.1 74314134 3670134 3959755..3960813 1 NC_007384.1 Code: M; COG: COG0859; lipopolysaccharide core biosynthesis protein 3960813 waaQ 3670134 waaQ Shigella sonnei Ss046 lipopolysaccharide core biosynthesis protein YP_312553.1 3959755 D 300269 CDS YP_312554.1 74314135 3670135 3960810..3961934 1 NC_007384.1 Code: M; COG: COG0438; LPS alpha1,3-glucosyltransferase 3961934 waaG 3670135 waaG Shigella sonnei Ss046 LPS alpha1,3-glucosyltransferase YP_312554.1 3960810 D 300269 CDS YP_312555.1 74314136 3670077 3961927..3962724 1 NC_007384.1 lipopolysaccharide core biosynthesis protein 3962724 waaP 3670077 waaP Shigella sonnei Ss046 lipopolysaccharide core biosynthesis protein YP_312555.1 3961927 D 300269 CDS YP_312556.1 74314137 3670078 3962740..3963756 1 NC_007384.1 Code: M; COG: COG1442; UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase 3963756 waaI 3670078 waaI Shigella sonnei Ss046 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase YP_312556.1 3962740 D 300269 CDS YP_312557.1 74314138 3670079 3963773..3964768 1 NC_007384.1 Code: M; COG: COG1442; lipopolysaccharide 1,2-glucosyltransferase 3964768 waaJ 3670079 waaJ Shigella sonnei Ss046 lipopolysaccharide 1,2-glucosyltransferase YP_312557.1 3963773 D 300269 CDS YP_312558.1 74314139 3670080 3964778..3965470 1 NC_007384.1 lipopolysaccharide core biosynthesis protein 3965470 waaY 3670080 waaY Shigella sonnei Ss046 lipopolysaccharide core biosynthesis protein YP_312558.1 3964778 D 300269 CDS YP_312559.1 74314140 3670081 3965496..3966521 1 NC_007384.1 Code: M; COG: COG1442; UDP-galactose:(galactosyl) LPS alpha1,2-galactosyltransferase 3966521 waaW 3670081 waaW Shigella sonnei Ss046 UDP-galactose:(galactosyl) LPS alpha1,2-galactosyltransferase YP_312559.1 3965496 D 300269 CDS YP_312560.1 74314141 3670082 3966606..3967589 1 NC_007384.1 Code: M; COG: COG0463; beta1,3-glucosyltransferase 3967589 waaV 3670082 waaV Shigella sonnei Ss046 beta1,3-glucosyltransferase YP_312560.1 3966606 D 300269 CDS YP_312561.1 74314142 3670083 3967635..3968888 1 NC_007384.1 lipid A-core, surface polymer ligase 3968888 waaL 3670083 waaL Shigella sonnei Ss046 lipid A-core, surface polymer ligase YP_312561.1 3967635 D 300269 CDS YP_312562.1 74314143 3670084 complement(3968958..3969929) 1 NC_007384.1 lipopolysaccharide core biosynthesis; Code: M; COG: COG0859; ADP-heptose--LPS heptosyltransferase 3969929 rfaC 3670084 rfaC Shigella sonnei Ss046 ADP-heptose--LPS heptosyltransferase YP_312562.1 3968958 R 300269 CDS YP_312563.1 74314144 3670085 complement(3969933..3970979) 1 NC_007384.1 lipopolysaccharide core biosynthesis; catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose--LPS heptosyltransferase 3970979 rfaF 3670085 rfaF Shigella sonnei Ss046 ADP-heptose--LPS heptosyltransferase YP_312563.1 3969933 R 300269 CDS YP_312564.1 74314145 3670086 complement(3970989..3971921) 1 NC_007384.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-manno-heptose-6-epimerase 3971921 rfaD 3670086 rfaD Shigella sonnei Ss046 ADP-L-glycero-D-manno-heptose-6-epimerase YP_312564.1 3970989 R 300269 CDS YP_312565.1 74314146 3670087 3972135..3973331 1 NC_007384.1 glycine acetyltransferase; catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate CoA ligase 3973331 kbl 3670087 kbl Shigella sonnei Ss046 2-amino-3-ketobutyrate CoA ligase YP_312565.1 3972135 D 300269 CDS YP_312566.1 74314147 3670088 3973341..3974366 1 NC_007384.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 3974366 tdh 3670088 tdh Shigella sonnei Ss046 L-threonine 3-dehydrogenase YP_312566.1 3973341 D 300269 CDS YP_312567.1 74314148 3670090 complement(3975518..3976021) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 3976021 3670090 SSON_3790 Shigella sonnei Ss046 IS1 ORF YP_312567.1 3975518 R 300269 CDS YP_312568.1 74314149 3670091 complement(3976403..3977236) 1 NC_007384.1 Code: S; COG: COG2861; hypothetical protein 3977236 yibQ 3670091 yibQ Shigella sonnei Ss046 hypothetical protein YP_312568.1 3976403 R 300269 CDS YP_312569.1 74314150 3670092 complement(3977366..3978649) 1 NC_007384.1 Code: D; COG: COG4942; hypothetical protein 3978649 yibP 3670092 yibP Shigella sonnei Ss046 hypothetical protein YP_312569.1 3977366 R 300269 CDS YP_312570.1 74314151 3670093 complement(3978659..3980203) 1 NC_007384.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 3980203 yibO 3670093 yibO Shigella sonnei Ss046 phosphoglyceromutase YP_312570.1 3978659 R 300269 CDS YP_312571.1 74314152 3670094 3980448..3980879 1 NC_007384.1 Code: P; COG: COG0607; hypothetical protein 3980879 yibN 3670094 yibN Shigella sonnei Ss046 hypothetical protein YP_312571.1 3980448 D 300269 CDS YP_312572.1 74314153 3670095 3981021..3981272 1 NC_007384.1 Code: O; COG: COG0695; glutaredoxin 3 3981272 grxC 3670095 grxC Shigella sonnei Ss046 glutaredoxin 3 YP_312572.1 3981021 D 300269 CDS YP_312573.1 74314154 3670057 3981335..3981802 1 NC_007384.1 protein export; molecular chaperone; may bind to signel sequence; molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 3981802 secB 3670057 secB Shigella sonnei Ss046 preprotein translocase subunit SecB YP_312573.1 3981335 D 300269 CDS YP_312574.1 74314155 3670058 3981802..3982821 1 NC_007384.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 3982821 gpsA 3670058 gpsA Shigella sonnei Ss046 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_312574.1 3981802 D 300269 CDS YP_312575.1 74314156 3670059 3982901..3983722 1 NC_007384.1 catalyzes the O-acetylation of serine; serine acetyltransferase 3983722 cysE 3670059 cysE Shigella sonnei Ss046 serine acetyltransferase YP_312575.1 3982901 D 300269 CDS YP_312576.1 74314157 3670060 complement(3983775..3984248) 1 NC_007384.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; tRNA/rRNA methyltransferase YibK 3984248 yibK 3670060 yibK Shigella sonnei Ss046 tRNA/rRNA methyltransferase YibK YP_312576.1 3983775 R 300269 CDS YP_312577.1 74314158 3670061 complement(3984444..3985634) 1 NC_007384.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 3985634 lldD 3670061 lldD Shigella sonnei Ss046 L-lactate dehydrogenase YP_312577.1 3984444 R 300269 CDS YP_312578.1 74314159 3670062 complement(3985631..3986407) 1 NC_007384.1 represses the lctPRD operon; DNA-binding transcriptional repressor LldR 3986407 lldR 3670062 lldR Shigella sonnei Ss046 DNA-binding transcriptional repressor LldR YP_312578.1 3985631 R 300269 CDS YP_312579.1 74314160 3670063 complement(3986407..3988062) 1 NC_007384.1 Code: C; COG: COG1620; L-lactate permease 3988062 lldP 3670063 lldP Shigella sonnei Ss046 L-lactate permease YP_312579.1 3986407 R 300269 CDS YP_312580.1 74314161 3670064 complement(3988430..3993280) 1 NC_007384.1 Code: UW; COG: COG5295; adhesin 3993280 3670064 SSON_3803 Shigella sonnei Ss046 adhesin YP_312580.1 3988430 R 300269 CDS YP_312581.1 74314162 3670065 complement(3993324..3993662) 1 NC_007384.1 hypothetical protein 3993662 3670065 SSON_3804 Shigella sonnei Ss046 hypothetical protein YP_312581.1 3993324 R 300269 CDS YP_312582.1 74314163 3670066 complement(3994545..3994907) 1 NC_007384.1 hypothetical protein 3994907 yibL 3670066 yibL Shigella sonnei Ss046 hypothetical protein YP_312582.1 3994545 R 300269 CDS YP_312583.1 74314164 3670067 3995192..3995401 1 NC_007384.1 hypothetical protein 3995401 3670067 SSON_3806 Shigella sonnei Ss046 hypothetical protein YP_312583.1 3995192 D 300269 CDS YP_312584.1 74314165 3670068 complement(3995413..3996000) 1 NC_007384.1 Acts as a repressor of the mtlAD operon; mannitol repressor protein 3996000 mtlR 3670068 mtlR Shigella sonnei Ss046 mannitol repressor protein YP_312584.1 3995413 R 300269 CDS YP_312585.1 74314166 3670069 complement(3996000..3997148) 1 NC_007384.1 Code: G; COG: COG0246; mannitol-1-phosphate 5-dehydrogenase 3997148 mtlD 3670069 mtlD Shigella sonnei Ss046 mannitol-1-phosphate 5-dehydrogenase YP_312585.1 3996000 R 300269 CDS YP_312586.1 74314167 3670070 complement(3997377..3999290) 1 NC_007384.1 Code: G; COG: COG2213; PTS system mannitol-specific transporter subunit IIABC 3999290 mtlA 3670070 mtlA Shigella sonnei Ss046 PTS system mannitol-specific transporter subunit IIABC YP_312586.1 3997377 R 300269 CDS YP_312587.1 74314168 3670071 3999827..4000189 1 NC_007384.1 hypothetical protein 4000189 yibI 3670071 yibI Shigella sonnei Ss046 hypothetical protein YP_312587.1 3999827 D 300269 CDS YP_312588.1 74314169 3670072 complement(4001019..4002554) 1 NC_007384.1 Code: L; COG: COG4584; transposase encoded within IS 4002554 3670072 SSON_3811 Shigella sonnei Ss046 transposase encoded within IS YP_312588.1 4001019 R 300269 CDS YP_312589.1 74314170 3670073 4002727..4003890 1 NC_007384.1 Code: V; COG: COG1566; hypothetical protein 4003890 yibH 3670073 yibH Shigella sonnei Ss046 hypothetical protein YP_312589.1 4002727 D 300269 CDS YP_312590.1 74314171 3670074 complement(4004876..4007824) 1 NC_007384.1 Code: M; COG: COG3209; rhsB protein in rhs element 4007824 rhsB 3670074 rhsB Shigella sonnei Ss046 rhsB protein in rhs element YP_312590.1 4004876 R 300269 CDS YP_312591.1 74314172 3670075 complement(4007849..4008175) 1 NC_007384.1 hypothetical protein 4008175 3670075 SSON_3814 Shigella sonnei Ss046 hypothetical protein YP_312591.1 4007849 R 300269 CDS YP_312592.1 74314173 3670076 complement(4008166..4009050) 1 NC_007384.1 hypothetical protein 4009050 3670076 SSON_3815 Shigella sonnei Ss046 hypothetical protein YP_312592.1 4008166 R 300269 CDS YP_312593.1 74314174 3670038 4009279..4009887 1 NC_007384.1 Code: O; COG: COG0625; glutathione S-transferase 4009887 yibF 3670038 yibF Shigella sonnei Ss046 glutathione S-transferase YP_312593.1 4009279 D 300269 CDS YP_312594.1 74314175 3670039 4009985..4011376 1 NC_007384.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 4011376 selA 3670039 selA Shigella sonnei Ss046 selenocysteine synthase YP_312594.1 4009985 D 300269 CDS YP_312595.1 74314176 3670040 4011373..4013217 1 NC_007384.1 Code: J; COG: COG3276; selenocysteinyl-tRNA-specific translation factor 4013217 selB 3670040 selB Shigella sonnei Ss046 selenocysteinyl-tRNA-specific translation factor YP_312595.1 4011373 D 300269 CDS YP_312596.1 74314177 3670041 complement(4013277..4013780) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4013780 3670041 SSON_3819 Shigella sonnei Ss046 IS1 ORF YP_312596.1 4013277 R 300269 CDS YP_312597.1 74314178 3670042 4014034..4015356 1 NC_007384.1 catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase 4015356 xylA 3670042 xylA Shigella sonnei Ss046 xylose isomerase YP_312597.1 4014034 D 300269 CDS YP_312598.1 74314179 3670043 4015428..4016759 1 NC_007384.1 Code: G; COG: COG1070; xylulokinase 4016759 xylB 3670043 xylB Shigella sonnei Ss046 xylulokinase YP_312598.1 4015428 D 300269 CDS YP_312599.1 74314180 3670044 4017040..4017393 1 NC_007384.1 Code: S; COG: COG4682; hypothetical protein 4017393 yiaB 3670044 yiaB Shigella sonnei Ss046 hypothetical protein YP_312599.1 4017040 D 300269 CDS YP_312600.2 161986417 3670045 complement(4017595..4018500) 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 4018500 3670045 SSON_3823 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_312600.2 4017595 R 300269 CDS YP_312601.1 74314182 3670046 complement(4018458..4018823) 1 NC_007384.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 4018823 3670046 SSON_3824 Shigella sonnei Ss046 insertion sequence 2 OrfA protein YP_312601.1 4018458 R 300269 CDS YP_312602.1 74314183 3670047 4019107..4019409 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 4019409 3670047 SSON_3825 Shigella sonnei Ss046 IS600 ORF1 YP_312602.1 4019107 D 300269 CDS YP_312603.1 74314184 3670048 4019550..4020263 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 4020263 3670048 SSON_3826 Shigella sonnei Ss046 IS600 ORF2 YP_312603.1 4019550 D 300269 CDS YP_312604.1 74314185 3670049 complement(4020521..4021516) 1 NC_007384.1 Code: S; COG: COG3274; hypothetical protein 4021516 yiaH 3670049 yiaH Shigella sonnei Ss046 hypothetical protein YP_312604.1 4020521 R 300269 CDS YP_312605.1 74314186 3670050 4021691..4021990 1 NC_007384.1 lipoprotein 4021990 3670050 SSON_3828 Shigella sonnei Ss046 lipoprotein YP_312605.1 4021691 D 300269 CDS YP_312606.1 74314187 3670051 4022085..4022996 1 NC_007384.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 4022996 glyQ 3670051 glyQ Shigella sonnei Ss046 glycyl-tRNA synthetase subunit alpha YP_312606.1 4022085 D 300269 CDS YP_312607.1 74314188 3670052 4023006..4025075 1 NC_007384.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 4025075 glyS 3670052 glyS Shigella sonnei Ss046 glycyl-tRNA synthetase subunit beta YP_312607.1 4023006 D 300269 CDS YP_312608.1 74314189 3670053 4025401..4025553 1 NC_007384.1 small toxic polypeptide 4025553 yiaZ 3670053 yiaZ Shigella sonnei Ss046 small toxic polypeptide YP_312608.1 4025401 D 300269 CDS YP_312609.1 74314190 3670054 complement(4025741..4025953) 1 NC_007384.1 Code: K; COG: COG1278; cold-shock protein 4025953 cspA 3670054 cspA Shigella sonnei Ss046 cold-shock protein YP_312609.1 4025741 R 300269 CDS YP_312610.1 74314191 3670055 complement(4026234..4026524) 1 NC_007384.1 Code: K; COG: COG2944; transcriptional regulator 4026524 yiaG 3670055 yiaG Shigella sonnei Ss046 transcriptional regulator YP_312610.1 4026234 R 300269 CDS YP_312611.1 74314192 3670056 4026838..4027668 1 NC_007384.1 hypothetical protein 4027668 yiaF 3670056 yiaF Shigella sonnei Ss046 hypothetical protein YP_312611.1 4026838 D 300269 CDS YP_312612.2 161986416 3669962 complement(4027718..4028692) 1 NC_007384.1 Code: CHR; COG: COG1052; dehydrogenase 4028692 yiaE 3669962 yiaE Shigella sonnei Ss046 dehydrogenase YP_312612.2 4027718 R 300269 CDS YP_312613.1 74314194 3669963 complement(4028796..4029455) 1 NC_007384.1 Code: M; COG: COG2885; outer membrane lipoprotein 4029455 yiaD 3669963 yiaD Shigella sonnei Ss046 outer membrane lipoprotein YP_312613.1 4028796 R 300269 CDS YP_312614.1 74314195 3669964 complement(4029574..4030287) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 4030287 3669964 SSON_3837 Shigella sonnei Ss046 IS600 ORF2 YP_312614.1 4029574 R 300269 CDS YP_312615.1 74314196 3669965 complement(4030429..4030731) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 4030731 3669965 SSON_3838 Shigella sonnei Ss046 IS600 ORF1 YP_312615.1 4030429 R 300269 CDS YP_312616.1 74314197 3669966 4030990..4033191 1 NC_007384.1 Code: C; COG: COG0243; biotin sulfoxide reductase 4033191 bisC 3669966 bisC Shigella sonnei Ss046 biotin sulfoxide reductase YP_312616.1 4030990 D 300269 CDS YP_312617.1 74314198 3669967 complement(4033160..4033600) 1 NC_007384.1 Code: KR; COG: COG0454; hypothetical protein 4033600 yiaC 3669967 yiaC Shigella sonnei Ss046 hypothetical protein YP_312617.1 4033160 R 300269 CDS YP_312618.1 74314199 3669968 complement(4033597..4034160) 1 NC_007384.1 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyladenine DNA glycosylase 4034160 tag 3669968 tag Shigella sonnei Ss046 3-methyladenine DNA glycosylase YP_312618.1 4033597 R 300269 CDS YP_312619.1 74314200 3669969 4034312..4035016 1 NC_007384.1 Code: N; COG: COG5571; lipase 4035016 yhjY 3669969 yhjY Shigella sonnei Ss046 lipase YP_312619.1 4034312 D 300269 CDS YP_312620.1 74314201 3669970 4035245..4036453 1 NC_007384.1 Code: GEPR; COG: COG0477; resistance protein 4036453 yhjX 3669970 yhjX Shigella sonnei Ss046 resistance protein YP_312620.1 4035245 D 300269 CDS YP_312621.2 161986415 3669971 4036777..4038468 1 NC_007384.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase 4038468 yhjW 3669971 yhjW Shigella sonnei Ss046 phosphoethanolamine transferase YP_312621.2 4036777 D 300269 CDS YP_312622.1 74314203 3669973 4039717..4041324 1 NC_007384.1 Code: E; COG: COG0747; dipeptide transport protein 4041324 dppA 3669973 dppA Shigella sonnei Ss046 dipeptide transport protein YP_312622.1 4039717 D 300269 CDS YP_312623.1 74314204 3669974 4041632..4042651 1 NC_007384.1 transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB 4042651 dppB 3669974 dppB Shigella sonnei Ss046 dipeptide transporter permease DppB YP_312623.1 4041632 D 300269 CDS YP_312624.1 74314205 3669975 4042661..4043563 1 NC_007384.1 Code: EP; COG: COG1173; dipeptide transporter 4043563 dppC 3669975 dppC Shigella sonnei Ss046 dipeptide transporter YP_312624.1 4042661 D 300269 CDS YP_312625.1 74314206 3669976 4043574..4044557 1 NC_007384.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit 4044557 dppD 3669976 dppD Shigella sonnei Ss046 dipeptide transporter ATP-binding subunit YP_312625.1 4043574 D 300269 CDS YP_312626.1 74314207 3669977 4044554..4045558 1 NC_007384.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit 4045558 dppF 3669977 dppF Shigella sonnei Ss046 dipeptide transporter ATP-binding subunit YP_312626.1 4044554 D 300269 CDS YP_312627.1 74314208 3669978 complement(4045588..4046859) 1 NC_007384.1 Code: E; COG: COG0814; transporter protein 4046859 yhjV 3669978 yhjV Shigella sonnei Ss046 transporter protein YP_312627.1 4045588 R 300269 CDS YP_312628.1 74314209 3669979 complement(4050427..4052106) 1 NC_007384.1 hypothetical protein 4052106 yhjU 3669979 yhjU Shigella sonnei Ss046 hypothetical protein YP_312628.1 4050427 R 300269 CDS YP_312629.1 74314210 3669980 complement(4052103..4052291) 1 NC_007384.1 hypothetical protein 4052291 yhjT 3669980 yhjT Shigella sonnei Ss046 hypothetical protein YP_312629.1 4052103 R 300269 CDS YP_312630.1 74314211 3669925 complement(4052291..4053862) 1 NC_007384.1 protease 4053862 yhjS 3669925 yhjS Shigella sonnei Ss046 protease YP_312630.1 4052291 R 300269 CDS YP_312631.1 74314212 3669926 complement(4053918..4054421) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4054421 3669926 SSON_3855 Shigella sonnei Ss046 IS1 ORF YP_312631.1 4053918 R 300269 CDS YP_312632.1 74314213 3669927 4054869..4055057 1 NC_007384.1 hypothetical protein 4055057 yhjR 3669927 yhjR Shigella sonnei Ss046 hypothetical protein YP_312632.1 4054869 D 300269 CDS YP_312633.1 74314214 3669928 4055093..4055821 1 NC_007384.1 Code: D; COG: COG1192; cell division protein 4055821 yhjQ 3669928 yhjQ Shigella sonnei Ss046 cell division protein YP_312633.1 4055093 D 300269 CDS YP_312634.1 74314215 3669930 4058447..4060786 1 NC_007384.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein 4060786 yhjN 3669930 yhjN Shigella sonnei Ss046 cellulose synthase regulator protein YP_312634.1 4058447 D 300269 CDS YP_312635.1 74314216 3669931 4060793..4061899 1 NC_007384.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase 4061899 yhjM 3669931 yhjM Shigella sonnei Ss046 endo-1,4-D-glucanase YP_312635.1 4060793 D 300269 CDS YP_312636.1 74314217 3669933 4065488..4067443 1 NC_007384.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a phosphodiesterase protein from E. coli; phosphodiesterase 4067443 yhjK 3669933 yhjK Shigella sonnei Ss046 phosphodiesterase YP_312636.1 4065488 D 300269 CDS YP_312637.1 74314218 3669934 4067626..4068912 1 NC_007384.1 involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA 4068912 dctA 3669934 dctA Shigella sonnei Ss046 C4-dicarboxylate transporter DctA YP_312637.1 4067626 D 300269 CDS YP_312638.1 74314219 3669935 4069132..4070628 1 NC_007384.1 Code: R; COG: COG0612; hypothetical protein 4070628 yhjJ 3669935 yhjJ Shigella sonnei Ss046 hypothetical protein YP_312638.1 4069132 D 300269 CDS YP_312639.1 74314220 3669936 complement(4070724..4071872) 1 NC_007384.1 Code: G; COG: COG0524; ketodeoxygluconokinase 4071872 kdgK 3669936 kdgK Shigella sonnei Ss046 ketodeoxygluconokinase YP_312639.1 4070724 R 300269 CDS YP_312640.1 74314221 3669937 4071882..4072652 1 NC_007384.1 in Escherichia coli this protein is involved in flagellar function; diguanylate phosphodiesterase 4072652 yhjH 3669937 yhjH Shigella sonnei Ss046 diguanylate phosphodiesterase YP_312640.1 4071882 D 300269 CDS YP_312641.1 74314222 3669938 4072707..4074782 1 NC_007384.1 Code: M; COG: COG2982; hypothetical protein 4074782 yhjG 3669938 yhjG Shigella sonnei Ss046 hypothetical protein YP_312641.1 4072707 D 300269 CDS YP_312642.1 74314223 3669939 complement(4074964..4076286) 1 NC_007384.1 Code: GEPR; COG: COG0477; transporter 4076286 yhjE 3669939 yhjE Shigella sonnei Ss046 transporter YP_312642.1 4074964 R 300269 CDS YP_312643.1 74314224 3669940 complement(4076697..4077710) 1 NC_007384.1 Code: S; COG: COG1295; hypothetical protein 4077710 yhjD 3669940 yhjD Shigella sonnei Ss046 hypothetical protein YP_312643.1 4076697 R 300269 CDS YP_312644.1 74314225 3669941 complement(4077759..4078730) 1 NC_007384.1 Code: K; COG: COG0583; LysR family transcriptional regulator 4078730 yhjC 3669941 yhjC Shigella sonnei Ss046 LysR family transcriptional regulator YP_312644.1 4077759 R 300269 CDS YP_312645.1 74314226 3669942 4079178..4079780 1 NC_007384.1 Code: TK; COG: COG2197; regulator 4079780 yhjB 3669942 yhjB Shigella sonnei Ss046 regulator YP_312645.1 4079178 D 300269 CDS YP_312646.1 74314227 3669943 complement(4079796..4081142) 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 4081142 3669943 SSON_3872 Shigella sonnei Ss046 IS4 orf YP_312646.1 4079796 R 300269 CDS YP_312647.2 228861777 3669905 4081298..4082794 1 NC_007384.1 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA 4082794 yieN 3669905 yieN Shigella sonnei Ss046 regulatory ATPase RavA YP_312647.2 4081298 D 300269 CDS YP_312648.1 74314229 3669906 4082788..4084239 1 NC_007384.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein 4084239 yieM 3669906 yieM Shigella sonnei Ss046 hypothetical protein YP_312648.1 4082788 D 300269 CDS YP_312649.1 74314230 3669907 complement(4084244..4085236) 1 NC_007384.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 4085236 asnA 3669907 asnA Shigella sonnei Ss046 asparagine synthetase AsnA YP_312649.1 4084244 R 300269 CDS YP_312650.1 74314231 3669908 4085388..4085846 1 NC_007384.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 4085846 asnC 3669908 asnC Shigella sonnei Ss046 DNA-binding transcriptional regulator AsnC YP_312650.1 4085388 D 300269 CDS YP_312651.1 74314232 3669909 4085936..4086379 1 NC_007384.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 4086379 mioC 3669909 mioC Shigella sonnei Ss046 flavodoxin YP_312651.1 4085936 D 300269 CDS YP_312652.1 74314233 3669910 4086758..4088647 1 NC_007384.1 glucose-inhibited division; possibly involved in chromosome replication; GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 4088647 gidA 3669910 gidA Shigella sonnei Ss046 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA YP_312652.1 4086758 D 300269 CDS YP_312653.1 74314234 3669911 4088711..4089334 1 NC_007384.1 glucose-inhibited division; possibly involved in chromosome replication; glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 4089334 gidB 3669911 gidB Shigella sonnei Ss046 16S rRNA methyltransferase GidB YP_312653.1 4088711 D 300269 CDS YP_312654.2 161986414 3669912 4089951..4090331 1 NC_007384.1 dispensable protein; affects expression of atpB; Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I 4090331 atpI 3669912 atpI Shigella sonnei Ss046 F0F1 ATP synthase subunit I YP_312654.2 4089951 D 300269 CDS YP_312655.1 74314236 3669913 4090340..4091155 1 NC_007384.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 4091155 atpB 3669913 atpB Shigella sonnei Ss046 ATP synthase F0F1 subunit A YP_312655.1 4090340 D 300269 CDS YP_312656.1 74314237 3669914 4091202..4091441 1 NC_007384.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 4091441 atpE 3669914 atpE Shigella sonnei Ss046 ATP synthase F0F1 subunit C YP_312656.1 4091202 D 300269 CDS YP_312657.1 74314238 3669915 4091503..4091973 1 NC_007384.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 4091973 atpF 3669915 atpF Shigella sonnei Ss046 ATP synthase F0F1 subunit B YP_312657.1 4091503 D 300269 CDS YP_312658.1 74314239 3669916 4091988..4092521 1 NC_007384.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 4092521 atpH 3669916 atpH Shigella sonnei Ss046 ATP synthase F0F1 subunit delta YP_312658.1 4091988 D 300269 CDS YP_312659.1 74314240 3669917 4092534..4094075 1 NC_007384.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 4094075 atpA 3669917 atpA Shigella sonnei Ss046 ATP synthase F0F1 subunit alpha YP_312659.1 4092534 D 300269 CDS YP_312660.1 74314241 3669918 4094126..4094989 1 NC_007384.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 4094989 atpG 3669918 atpG Shigella sonnei Ss046 ATP synthase F0F1 subunit gamma YP_312660.1 4094126 D 300269 CDS YP_312661.1 74314242 3669919 4095016..4096398 1 NC_007384.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 4096398 atpD 3669919 atpD Shigella sonnei Ss046 ATP synthase F0F1 subunit beta YP_312661.1 4095016 D 300269 CDS YP_312662.1 74314243 3669920 4096419..4096838 1 NC_007384.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 4096838 atpC 3669920 atpC Shigella sonnei Ss046 ATP synthase F0F1 subunit epsilon YP_312662.1 4096419 D 300269 CDS YP_312663.1 74314244 3669921 4097189..4098559 1 NC_007384.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 4098559 glmU 3669921 glmU Shigella sonnei Ss046 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_312663.1 4097189 D 300269 CDS YP_312664.1 74314245 3669922 4098721..4100550 1 NC_007384.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 4100550 glmS 3669922 glmS Shigella sonnei Ss046 glucosamine--fructose-6-phosphate aminotransferase YP_312664.1 4098721 D 300269 CDS YP_312665.1 74314246 3669923 4100934..4101530 1 NC_007384.1 transposase 4101530 3669923 SSON_3891 Shigella sonnei Ss046 transposase YP_312665.1 4100934 D 300269 CDS YP_312666.1 74314247 3669924 4101517..4103625 1 NC_007384.1 transposase 4103625 3669924 SSON_3892 Shigella sonnei Ss046 transposase YP_312666.1 4101517 D 300269 CDS YP_312667.1 74314248 3669886 4103622..4105289 1 NC_007384.1 ATP-binding protein 4105289 tnsC 3669886 tnsC Shigella sonnei Ss046 ATP-binding protein YP_312667.1 4103622 D 300269 CDS YP_312668.1 74314249 3669887 4105292..4106818 1 NC_007384.1 transposition protein 4106818 tnsD 3669887 tnsD Shigella sonnei Ss046 transposition protein YP_312668.1 4105292 D 300269 CDS YP_312669.1 74314250 3669888 4106927..4108435 1 NC_007384.1 transposition regulatory protein 4108435 tnsE 3669888 tnsE Shigella sonnei Ss046 transposition regulatory protein YP_312669.1 4106927 D 300269 CDS YP_312670.1 74314251 3669889 complement(4110458..4111246) 1 NC_007384.1 streptomycin 3'-adenyltransferase; aminoglycoside resistance protein 4111246 aadA 3669889 aadA Shigella sonnei Ss046 aminoglycoside resistance protein YP_312670.1 4110458 R 300269 CDS YP_312671.1 74314252 3669891 4114725..4116071 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 4116071 3669891 SSON_3898 Shigella sonnei Ss046 IS4 orf YP_312671.1 4114725 D 300269 CDS YP_312672.1 74314253 3669892 4116363..4116935 1 NC_007384.1 Code: NU; COG: COG3539; major fimbrial subunit 4116935 lpfA 3669892 lpfA Shigella sonnei Ss046 major fimbrial subunit YP_312672.1 4116363 D 300269 CDS YP_312673.1 74314254 3669893 4116983..4117285 1 NC_007384.1 Code: NU; COG: COG3121; fimbrial chaperone 4117285 3669893 SSON_3900 Shigella sonnei Ss046 fimbrial chaperone YP_312673.1 4116983 D 300269 CDS YP_312674.1 74314255 3669894 complement(4117296..4117799) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4117799 3669894 SSON_3901 Shigella sonnei Ss046 IS1 ORF YP_312674.1 4117296 R 300269 CDS YP_312675.1 74314256 3669897 complement(4119494..4120333) 1 NC_007384.1 Code: L; COG: COG2801; IS911 ORF2 4120333 3669897 SSON_3904 Shigella sonnei Ss046 IS911 ORF2 YP_312675.1 4119494 R 300269 CDS YP_312676.1 74314257 3669898 4122301..4123374 1 NC_007384.1 Code: NU; COG: COG3539; fimbrial protein 4123374 3669898 SSON_3905 Shigella sonnei Ss046 fimbrial protein YP_312676.1 4122301 D 300269 CDS YP_312677.1 74314258 3669899 4123622..4124662 1 NC_007384.1 Code: P; COG: COG0226; phosphate ABC transporter substrate-binding protein 4124662 pstS 3669899 pstS Shigella sonnei Ss046 phosphate ABC transporter substrate-binding protein YP_312677.1 4123622 D 300269 CDS YP_312678.1 74314259 3669900 4124749..4125708 1 NC_007384.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PstC 4125708 pstC 3669900 pstC Shigella sonnei Ss046 phosphate transporter permease subunit PstC YP_312678.1 4124749 D 300269 CDS YP_312679.1 74314260 3669901 4125708..4126598 1 NC_007384.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PtsA 4126598 pstA 3669901 pstA Shigella sonnei Ss046 phosphate transporter permease subunit PtsA YP_312679.1 4125708 D 300269 CDS YP_312680.1 74314261 3669902 4126689..4127462 1 NC_007384.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 4127462 pstB 3669902 pstB Shigella sonnei Ss046 phosphate transporter ATP-binding protein YP_312680.1 4126689 D 300269 CDS YP_312681.1 74314262 3669903 4127477..4128202 1 NC_007384.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU 4128202 phoU 3669903 phoU Shigella sonnei Ss046 transcriptional regulator PhoU YP_312681.1 4127477 D 300269 CDS YP_312682.1 74314263 3669904 4128488..4129324 1 NC_007384.1 positive regulator of the beta-glucoside operon; transcriptional antiterminator; transcriptional antiterminator BglG 4129324 bglG 3669904 bglG Shigella sonnei Ss046 transcriptional antiterminator BglG YP_312682.1 4128488 D 300269 CDS YP_312683.1 74314264 3669810 4129458..4131335 1 NC_007384.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system beta-glucoside-specific transporter subunit IIABC 4131335 bglF 3669810 bglF Shigella sonnei Ss046 PTS system beta-glucoside-specific transporter subunit IIABC YP_312683.1 4129458 D 300269 CDS YP_312684.1 74314265 3669812 complement(4131971..4133059) 1 NC_007384.1 Code: L; COG: COG3547; transposase 4133059 3669812 SSON_3914 Shigella sonnei Ss046 transposase YP_312684.1 4131971 R 300269 CDS YP_312685.1 74314266 3669813 4134352..4135968 1 NC_007384.1 Code: G; COG: COG4580; receptor protein 4135968 yieC 3669813 yieC Shigella sonnei Ss046 receptor protein YP_312685.1 4134352 D 300269 CDS YP_312686.1 74314267 3669814 4136256..4137602 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 4137602 3669814 SSON_3916 Shigella sonnei Ss046 IS4 orf YP_312686.1 4136256 D 300269 CDS YP_312687.1 74314268 3669815 4137761..4139629 1 NC_007384.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 4139629 trkD 3669815 trkD Shigella sonnei Ss046 potassium transport protein Kup YP_312687.1 4137761 D 300269 CDS YP_312688.2 228861776 3669816 4139796..4140215 1 NC_007384.1 membrane-associated protein; cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 4140215 rbsD 3669816 rbsD Shigella sonnei Ss046 D-ribose pyranase YP_312688.2 4139796 D 300269 CDS YP_312689.1 74314270 3669817 4140223..4141728 1 NC_007384.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP-binding protein 4141728 rbsA 3669817 rbsA Shigella sonnei Ss046 D-ribose transporter ATP-binding protein YP_312689.1 4140223 D 300269 CDS YP_312690.1 74314271 3669818 4141733..4142698 1 NC_007384.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 4142698 rbsC 3669818 rbsC Shigella sonnei Ss046 ribose ABC transporter permease YP_312690.1 4141733 D 300269 CDS YP_312691.1 74314272 3669820 4143735..4144664 1 NC_007384.1 catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 4144664 rbsK 3669820 rbsK Shigella sonnei Ss046 ribokinase YP_312691.1 4143735 D 300269 CDS YP_312692.1 74314273 3669821 4144668..4145660 1 NC_007384.1 DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 4145660 rbsR 3669821 rbsR Shigella sonnei Ss046 transcriptional repressor RbsR YP_312692.1 4144668 D 300269 CDS YP_312693.1 74314274 3669822 complement(4145626..4147053) 1 NC_007384.1 Code: GEPR; COG: COG0477; transporter 4147053 yieO 3669822 yieO Shigella sonnei Ss046 transporter YP_312693.1 4145626 R 300269 CDS YP_312694.1 74314275 3669823 complement(4147076..4147624) 1 NC_007384.1 Code: K; COG: COG2186; hypothetical protein 4147624 yieP 3669823 yieP Shigella sonnei Ss046 hypothetical protein YP_312694.1 4147076 R 300269 CDS YP_312695.1 74314276 3669778 complement(4153569..4154408) 1 NC_007384.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR 4154408 yifDA 3669778 yifDA Shigella sonnei Ss046 transcriptional regulator HdfR YP_312695.1 4153569 R 300269 CDS YP_312696.1 74314277 3669779 4154527..4154865 1 NC_007384.1 Code: S; COG: COG3085; hypothetical protein 4154865 yifE 3669779 yifE Shigella sonnei Ss046 hypothetical protein YP_312696.1 4154527 D 300269 CDS YP_312697.1 74314278 3669780 complement(4155340..4156137) 1 NC_007384.1 Code: L; COG: COG1484; IS21 ORF2 4156137 3669780 SSON_3934 Shigella sonnei Ss046 IS21 ORF2 YP_312697.1 4155340 R 300269 CDS YP_312698.1 74314279 3669781 complement(4156137..4157309) 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 4157309 3669781 SSON_3935 Shigella sonnei Ss046 IS21 ORF1 YP_312698.1 4156137 R 300269 CDS YP_312699.1 74314280 3669782 4157910..4158413 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4158413 3669782 SSON_3936 Shigella sonnei Ss046 IS1 ORF YP_312699.1 4157910 D 300269 CDS YP_312700.1 74314281 3669784 4159675..4159773 1 NC_007384.1 ilvG operon leader peptide 4159773 ilvL 3669784 ilvL Shigella sonnei Ss046 ilvG operon leader peptide YP_312700.1 4159675 D 300269 CDS YP_312701.1 74314282 3669785 4159913..4161559 1 NC_007384.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 4161559 ilvG 3669785 ilvG Shigella sonnei Ss046 acetolactate synthase 2 catalytic subunit YP_312701.1 4159913 D 300269 CDS YP_312702.1 74314283 3669786 4161556..4161819 1 NC_007384.1 Code: S; COG: COG3978; acetolactate synthase 2 regulatory subunit 4161819 ilvM 3669786 ilvM Shigella sonnei Ss046 acetolactate synthase 2 regulatory subunit YP_312702.1 4161556 D 300269 CDS YP_312703.1 74314284 3669787 4161839..4162768 1 NC_007384.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 4162768 ilvE 3669787 ilvE Shigella sonnei Ss046 branched-chain amino acid aminotransferase YP_312703.1 4161839 D 300269 CDS YP_312704.1 74314285 3669788 4162833..4164683 1 NC_007384.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 4164683 ilvD 3669788 ilvD Shigella sonnei Ss046 dihydroxy-acid dehydratase YP_312704.1 4162833 D 300269 CDS YP_312705.1 74314286 3669789 4164686..4166230 1 NC_007384.1 dehydratase; threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 4166230 ilvA 3669789 ilvA Shigella sonnei Ss046 threonine dehydratase YP_312705.1 4164686 D 300269 CDS YP_312706.1 74314287 3669790 complement(4166282..4167175) 1 NC_007384.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 4167175 ilvY 3669790 ilvY Shigella sonnei Ss046 DNA-binding transcriptional regulator IlvY YP_312706.1 4166282 R 300269 CDS YP_312707.1 74314288 3669755 4167325..4168800 1 NC_007384.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 4168800 ilvC 3669755 ilvC Shigella sonnei Ss046 ketol-acid reductoisomerase YP_312707.1 4167325 D 300269 CDS YP_312708.1 74314289 3669756 complement(4168887..4169168) 1 NC_007384.1 rotamase C; Code: O; COG: COG0760; peptidyl-prolyl cis-trans isomerase C 4169168 ppiC 3669756 ppiC Shigella sonnei Ss046 peptidyl-prolyl cis-trans isomerase C YP_312708.1 4168887 R 300269 CDS YP_312709.2 161986413 3669757 complement(4169690..4170595) 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 4170595 3669757 SSON_3947 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_312709.2 4169690 R 300269 CDS YP_312710.1 74314291 3669758 complement(4170553..4170918) 1 NC_007384.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 4170918 3669758 SSON_3948 Shigella sonnei Ss046 insertion sequence 2 OrfA protein YP_312710.1 4170553 R 300269 CDS YP_312711.1 74314292 3669759 4171369..4173390 1 NC_007384.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 4173390 rep 3669759 rep Shigella sonnei Ss046 ATP-dependent DNA helicase Rep YP_312711.1 4171369 D 300269 CDS YP_312712.1 74314293 3669760 complement(4173437..4174921) 1 NC_007384.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase 4174921 gppA 3669760 gppA Shigella sonnei Ss046 guanosine pentaphosphate phosphohydrolase YP_312712.1 4173437 R 300269 CDS YP_312713.1 74314294 3669761 complement(4175055..4176320) 1 NC_007384.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB 4176320 rhlB 3669761 rhlB Shigella sonnei Ss046 ATP-dependent RNA helicase RhlB YP_312713.1 4175055 R 300269 CDS YP_312714.1 74314295 3669762 4176397..4176780 1 NC_007384.1 Code: OC; COG: COG0526; thioredoxin 4176780 trxA 3669762 trxA Shigella sonnei Ss046 thioredoxin YP_312714.1 4176397 D 300269 CDS YP_312715.1 74314296 3669763 4176921..4177022 1 NC_007384.1 rho operon leader peptide 4177022 rhoL 3669763 rhoL Shigella sonnei Ss046 rho operon leader peptide YP_312715.1 4176921 D 300269 CDS YP_312716.1 74314297 3669764 4177107..4178366 1 NC_007384.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 4178366 rho 3669764 rho Shigella sonnei Ss046 transcription termination factor Rho YP_312716.1 4177107 D 300269 CDS YP_312717.1 74314298 3669765 4178376..4178594 1 NC_007384.1 hypothetical protein 4178594 3669765 SSON_3955 Shigella sonnei Ss046 hypothetical protein YP_312717.1 4178376 D 300269 CDS YP_312718.1 74314299 3669766 4178606..4179709 1 NC_007384.1 synthesis of enterobacterial common antigen (ECA); Code: M; COG: COG0472; UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase 4179709 rfe 3669766 rfe Shigella sonnei Ss046 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase YP_312718.1 4178606 D 300269 CDS YP_312719.1 74314300 3669767 4179718..4180767 1 NC_007384.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 4180767 wzzE 3669767 wzzE Shigella sonnei Ss046 lipopolysaccharide biosynthesis protein WzzE YP_312719.1 4179718 D 300269 CDS YP_312720.1 74314301 3669768 4180781..4181953 1 NC_007384.1 Code: M; COG: COG0381; UDP-N-acetyl glucosamine-2-epimerase 4181953 wecB 3669768 wecB Shigella sonnei Ss046 UDP-N-acetyl glucosamine-2-epimerase YP_312720.1 4180781 D 300269 CDS YP_312721.1 74314302 3669769 4181950..4183212 1 NC_007384.1 synthesis of enterobacterial common antigen (ECA); catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 4183212 wecC 3669769 wecC Shigella sonnei Ss046 UDP-N-acetyl-D-mannosamine dehydrogenase YP_312721.1 4181950 D 300269 CDS YP_312722.1 74314303 3669770 4183212..4184279 1 NC_007384.1 Code: M; COG: COG1088; dTDP-glucose 4,6-dehydratase 4184279 rffG 3669770 rffG Shigella sonnei Ss046 dTDP-glucose 4,6-dehydratase YP_312722.1 4183212 D 300269 CDS YP_312723.1 74314304 3669771 4184298..4185179 1 NC_007384.1 Code: M; COG: COG1209; glucose-1-phosphate thymidylyltransferase 4185179 rffH 3669771 rffH Shigella sonnei Ss046 glucose-1-phosphate thymidylyltransferase YP_312723.1 4184298 D 300269 CDS YP_312724.1 74314305 3669772 4185286..4185831 1 NC_007384.1 Code: KR; COG: COG0454; TDP-fucosamine acetyltransferase 4185831 wecD 3669772 wecD Shigella sonnei Ss046 TDP-fucosamine acetyltransferase YP_312724.1 4185286 D 300269 CDS YP_312725.1 74314306 3669773 4185836..4186966 1 NC_007384.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 4186966 wecE 3669773 wecE Shigella sonnei Ss046 TDP-4-oxo-6-deoxy-D-glucose transaminase YP_312725.1 4185836 D 300269 CDS YP_312726.1 74314307 3669774 4186968..4188218 1 NC_007384.1 Code: R; COG: COG2244; cytochrome 4188218 wzxE 3669774 wzxE Shigella sonnei Ss046 cytochrome YP_312726.1 4186968 D 300269 CDS YP_312727.1 74314308 3669740 4188215..4189294 1 NC_007384.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 4189294 yifM 3669740 yifM Shigella sonnei Ss046 4-alpha-L-fucosyltransferase YP_312727.1 4188215 D 300269 CDS YP_312728.1 74314309 3669741 4189291..4190643 1 NC_007384.1 synthesis of enterobacterial common antigen (ECA); enterobacterial common antigen polymerase; common antigen polymerase 4190643 wecF 3669741 wecF Shigella sonnei Ss046 common antigen polymerase YP_312728.1 4189291 D 300269 CDS YP_312729.1 74314310 3669742 4190646..4191386 1 NC_007384.1 synthesis of enterobacterial common antigen (ECA); Code: M; COG: COG1922; UDP-N-acetyl-D-mannosaminuronic acid transferase 4191386 wecG 3669742 wecG Shigella sonnei Ss046 UDP-N-acetyl-D-mannosaminuronic acid transferase YP_312729.1 4190646 D 300269 CDS YP_312730.1 74314311 3669743 4191577..4192962 1 NC_007384.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; transporter 4192962 yifK 3669743 yifK Shigella sonnei Ss046 transporter YP_312730.1 4191577 D 300269 CDS YP_312731.1 74314312 3669748 4193646..4194881 1 NC_007384.1 Code: R; COG: COG0641; arylsulfatase regulator 4194881 aslB 3669748 aslB Shigella sonnei Ss046 arylsulfatase regulator YP_312731.1 4193646 D 300269 CDS YP_312732.1 74314313 3669749 complement(4195788..4196984) 1 NC_007384.1 a late step of protoheme IX synthesis; Code: H; COG: COG3071; protoheme IX biogenesis protein 4196984 hemY 3669749 hemY Shigella sonnei Ss046 protoheme IX biogenesis protein YP_312732.1 4195788 R 300269 CDS YP_312733.1 74314314 3669750 complement(4196987..4198204) 1 NC_007384.1 Code: H; COG: COG2959; uroporphyrinogen III C-methyltransferase 4198204 hemX 3669750 hemX Shigella sonnei Ss046 uroporphyrinogen III C-methyltransferase YP_312733.1 4196987 R 300269 CDS YP_312734.1 74314315 3669751 complement(4198226..4198966) 1 NC_007384.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 4198966 hemD 3669751 hemD Shigella sonnei Ss046 uroporphyrinogen-III synthase YP_312734.1 4198226 R 300269 CDS YP_312735.1 74314316 3669752 complement(4198963..4199925) 1 NC_007384.1 hydroxymethylbilane synthase; transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 4199925 hemC 3669752 hemC Shigella sonnei Ss046 porphobilinogen deaminase YP_312735.1 4198963 R 300269 CDS YP_312736.1 74314317 3669753 4200291..4202837 1 NC_007384.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 4202837 cyaA 3669753 cyaA Shigella sonnei Ss046 adenylate cyclase YP_312736.1 4200291 D 300269 CDS YP_312737.1 74314319 3669662 complement(4202877..4203197) 1 NC_007384.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 4203197 cyaY 3669662 cyaY Shigella sonnei Ss046 frataxin-like protein YP_312737.1 4202877 R 300269 CDS YP_312738.1 74314318 3669754 4202988..4203473 1 NC_007384.1 hypothetical protein 4203473 3669754 SSON_3979 Shigella sonnei Ss046 hypothetical protein YP_312738.1 4202988 D 300269 CDS YP_312739.1 74314320 3669663 4203744..4203947 1 NC_007384.1 Code: N; COG: COG5567; hypothetical protein 4203947 yifL 3669663 yifL Shigella sonnei Ss046 hypothetical protein YP_312739.1 4203744 D 300269 CDS YP_312740.2 161986412 3669664 4203984..4204808 1 NC_007384.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 4204808 dapF 3669664 dapF Shigella sonnei Ss046 diaminopimelate epimerase YP_312740.2 4203984 D 300269 CDS YP_312741.1 74314322 3669665 4204805..4205512 1 NC_007384.1 Code: S; COG: COG3159; hypothetical protein 4205512 yigA 3669665 yigA Shigella sonnei Ss046 hypothetical protein YP_312741.1 4204805 D 300269 CDS YP_312742.1 74314323 3669666 4205509..4206405 1 NC_007384.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 4206405 xerC 3669666 xerC Shigella sonnei Ss046 site-specific tyrosine recombinase XerC YP_312742.1 4205509 D 300269 CDS YP_312743.1 74314324 3669667 4206405..4207121 1 NC_007384.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 4207121 yigB 3669667 yigB Shigella sonnei Ss046 flavin mononucleotide phosphatase YP_312743.1 4206405 D 300269 CDS YP_312744.1 74314325 3669668 4207205..4209367 1 NC_007384.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 4209367 uvrD 3669668 uvrD Shigella sonnei Ss046 DNA-dependent helicase II YP_312744.1 4207205 D 300269 CDS YP_312745.1 74314326 3669669 complement(4209422..4210324) 1 NC_007384.1 Code: S; COG: COG1912; hypothetical protein 4210324 3669669 SSON_3987 Shigella sonnei Ss046 hypothetical protein YP_312745.1 4209422 R 300269 CDS YP_312746.1 74314327 3669670 4210914..4211624 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 4211624 3669670 SSON_3988 Shigella sonnei Ss046 IS4 orf YP_312746.1 4210914 D 300269 CDS YP_312747.1 74314328 3669671 4211621..4212259 1 NC_007384.1 IS4 orf 4212259 3669671 SSON_3989 Shigella sonnei Ss046 IS4 orf YP_312747.1 4211621 D 300269 CDS YP_312748.1 74314329 3669673 4212978..4213928 1 NC_007384.1 responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 4213928 corA 3669673 corA Shigella sonnei Ss046 magnesium/nickel/cobalt transporter CorA YP_312748.1 4212978 D 300269 CDS YP_312749.1 74314330 3669674 complement(4215095..4215598) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4215598 3669674 SSON_3992 Shigella sonnei Ss046 IS1 ORF YP_312749.1 4215095 R 300269 CDS YP_312750.1 74314331 3669675 complement(4217384..4218271) 1 NC_007384.1 Code: R; COG: COG2962; hypothetical protein 4218271 rarD 3669675 rarD Shigella sonnei Ss046 hypothetical protein YP_312750.1 4217384 R 300269 CDS YP_312751.2 161986411 3669676 complement(4218323..4218790) 1 NC_007384.1 Code: Q; COG: COG2050; hypothetical protein 4218790 yigI 3669676 yigI Shigella sonnei Ss046 hypothetical protein YP_312751.2 4218323 R 300269 CDS YP_312752.1 74314333 3669677 4218955..4219824 1 NC_007384.1 catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 4219824 pldA 3669677 pldA Shigella sonnei Ss046 phospholipase A YP_312752.1 4218955 D 300269 CDS YP_312753.1 74314334 3669678 4219957..4221786 1 NC_007384.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ 4221786 recQ 3669678 recQ Shigella sonnei Ss046 ATP-dependent DNA helicase RecQ YP_312753.1 4219957 D 300269 CDS YP_312754.1 74314335 3669679 4222099..4222467 1 NC_007384.1 Code: E; COG: COG1280; hypothetical protein 4222467 yigJ 3669679 yigJ Shigella sonnei Ss046 hypothetical protein YP_312754.1 4222099 D 300269 CDS YP_312755.1 74314336 3669680 complement(4222529..4222945) 1 NC_007384.1 Code: E; COG: COG1280; hypothetical protein 4222945 yigK 3669680 yigK Shigella sonnei Ss046 hypothetical protein YP_312755.1 4222529 R 300269 CDS YP_312756.1 74314337 3669623 4223260..4224282 1 NC_007384.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 4224282 pldB 3669623 pldB Shigella sonnei Ss046 lysophospholipase L2 YP_312756.1 4223260 D 300269 CDS YP_312757.1 74314338 3669624 4224290..4225090 1 NC_007384.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; sugar phosphatase 4225090 yigL 3669624 yigL Shigella sonnei Ss046 sugar phosphatase YP_312757.1 4224290 D 300269 CDS YP_312758.1 74314339 3669625 4225166..4226065 1 NC_007384.1 Code: GER; COG: COG0697; hypothetical protein 4226065 yigM 3669625 yigM Shigella sonnei Ss046 hypothetical protein YP_312758.1 4225166 D 300269 CDS YP_312759.1 74314340 3669626 complement(4225953..4226906) 1 NC_007384.1 Code: K; COG: COG0583; regulator for metE and metH 4226906 metR 3669626 metR Shigella sonnei Ss046 regulator for metE and metH YP_312759.1 4225953 R 300269 CDS YP_312760.1 74314341 3669627 4227142..4229403 1 NC_007384.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 4229403 metE 3669627 metE Shigella sonnei Ss046 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase YP_312760.1 4227142 D 300269 CDS YP_312761.2 161986410 3669628 4230427..4231332 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 4231332 3669628 SSON_4004 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_312761.2 4230427 D 300269 CDS YP_312762.1 74314343 3669629 complement(4232801..4233490) 1 NC_007384.1 Code: Q; COG: COG0412; hydrolase 4233490 ysgA 3669629 ysgA Shigella sonnei Ss046 hydrolase YP_312762.1 4232801 R 300269 CDS YP_312763.1 74314344 3669630 4233875..4234636 1 NC_007384.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 4234636 udp 3669630 udp Shigella sonnei Ss046 uridine phosphorylase YP_312763.1 4233875 D 300269 CDS YP_312764.1 74314345 3669631 4234777..4236204 1 NC_007384.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 4236204 yigN 3669631 yigN Shigella sonnei Ss046 DNA recombination protein RmuC YP_312764.1 4234777 D 300269 CDS YP_312765.1 74314346 3669632 4236299..4237054 1 NC_007384.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 4237054 ubiE 3669632 ubiE Shigella sonnei Ss046 ubiquinone/menaquinone biosynthesis methyltransferase YP_312765.1 4236299 D 300269 CDS YP_312766.1 74314347 3669633 4237068..4237673 1 NC_007384.1 Code: S; COG: COG3165; hypothetical protein 4237673 yigP 3669633 yigP Shigella sonnei Ss046 hypothetical protein YP_312766.1 4237068 D 300269 CDS YP_312767.1 74314348 3669634 4237670..4239310 1 NC_007384.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; ubiquinone biosynthesis protein UbiB 4239310 ubiB 3669634 ubiB Shigella sonnei Ss046 ubiquinone biosynthesis protein UbiB YP_312767.1 4237670 D 300269 CDS YP_312768.1 74314349 3669635 4239347..4239658 1 NC_007384.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin-arginine translocation protein TatA 4239658 tatA 3669635 tatA Shigella sonnei Ss046 twin-arginine translocation protein TatA YP_312768.1 4239347 D 300269 CDS YP_312769.2 161986409 3669636 4239662..4240177 1 NC_007384.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 4240177 3669636 SSON_4012 Shigella sonnei Ss046 sec-independent translocase YP_312769.2 4239662 D 300269 CDS YP_312770.1 74314351 3669637 4240180..4240956 1 NC_007384.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 4240956 yigU 3669637 yigU Shigella sonnei Ss046 twin-arginine protein translocation system subunit TatC YP_312770.1 4240180 D 300269 CDS YP_312771.1 74314352 3669638 4240986..4241780 1 NC_007384.1 magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD 4241780 tatD 3669638 tatD Shigella sonnei Ss046 DNase TatD YP_312771.1 4240986 D 300269 CDS YP_312772.1 74314353 3669639 complement(4241777..4242265) 1 NC_007384.1 Code: K; COG: COG0250; transcriptional activator RfaH 4242265 rfaH 3669639 rfaH Shigella sonnei Ss046 transcriptional activator RfaH YP_312772.1 4241777 R 300269 CDS YP_312773.1 74314354 3669640 4242432..4243925 1 NC_007384.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 4243925 yigC 3669640 yigC Shigella sonnei Ss046 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_312773.1 4242432 D 300269 CDS YP_312774.1 74314355 3669641 4243972..4244673 1 NC_007384.1 flavin reductase (NADPH:flavin oxidoreductase); NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 4244673 fre 3669641 fre Shigella sonnei Ss046 FMN reductase YP_312774.1 4243972 D 300269 CDS YP_312775.1 74314356 3669642 complement(4244863..4246026) 1 NC_007384.1 3-ketoacyl-CoA thiolase; acetyl-CoA transferase; FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase 4246026 fadA 3669642 fadA Shigella sonnei Ss046 3-ketoacyl-CoA thiolase YP_312775.1 4244863 R 300269 CDS YP_312776.1 74314357 3669608 complement(4246036..4248225) 1 NC_007384.1 4-enzyme protein; includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha 4248225 fadB 3669608 fadB Shigella sonnei Ss046 multifunctional fatty acid oxidation complex subunit alpha YP_312776.1 4246036 R 300269 CDS YP_312777.1 74314358 3669609 4248415..4249746 1 NC_007384.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 4249746 pepQ 3669609 pepQ Shigella sonnei Ss046 proline dipeptidase YP_312777.1 4248415 D 300269 CDS YP_312778.1 74314359 3669610 4249743..4250360 1 NC_007384.1 Code: S; COG: COG1739; hypothetical protein 4250360 yigZ 3669610 yigZ Shigella sonnei Ss046 hypothetical protein YP_312778.1 4249743 D 300269 CDS YP_312779.1 74314360 3669611 4250399..4251850 1 NC_007384.1 Code: P; COG: COG0168; potassium transporter 4251850 trkH 3669611 trkH Shigella sonnei Ss046 potassium transporter YP_312779.1 4250399 D 300269 CDS YP_312780.1 74314361 3669612 4251862..4252407 1 NC_007384.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 4252407 hemG 3669612 hemG Shigella sonnei Ss046 protoporphyrinogen oxidase YP_312780.1 4251862 D 300269 CDS YP_312781.1 74314362 3669617 complement(4257898..4258410) 1 NC_007384.1 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; molybdopterin-guanine dinucleotide biosynthesis protein MobB 4258410 mobB 3669617 mobB Shigella sonnei Ss046 molybdopterin-guanine dinucleotide biosynthesis protein MobB YP_312781.1 4257898 R 300269 CDS YP_312782.1 74314363 3669618 complement(4258407..4258991) 1 NC_007384.1 molybdopterin ---> molybdopterin-guanine dinucleotide, protein Ar; in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA 4258991 mobA 3669618 mobA Shigella sonnei Ss046 molybdopterin-guanine dinucleotide biosynthesis protein MobA YP_312782.1 4258407 R 300269 CDS YP_312783.1 74314364 3669619 4259061..4259330 1 NC_007384.1 Code: S; COG: COG3084; hypothetical protein 4259330 yihD 3669619 yihD Shigella sonnei Ss046 hypothetical protein YP_312783.1 4259061 D 300269 CDS YP_312784.1 74314365 3669620 4259407..4260393 1 NC_007384.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 4260393 yihE 3669620 yihE Shigella sonnei Ss046 serine/threonine protein kinase YP_312784.1 4259407 D 300269 CDS YP_312785.1 74314366 3669621 4260410..4261036 1 NC_007384.1 essential for cytochrome c synthesis and formate-dependent reduction; Code: OC; COG: COG0526; protein disulfide isomerase I 4261036 dsbA 3669621 dsbA Shigella sonnei Ss046 protein disulfide isomerase I YP_312785.1 4260410 D 300269 CDS YP_312786.1 74314367 3669622 complement(4261063..4261566) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4261566 3669622 SSON_4033 Shigella sonnei Ss046 IS1 ORF YP_312786.1 4261063 R 300269 CDS YP_312787.1 74314368 3669589 complement(4262609..4263541) 1 NC_007384.1 Code: I; COG: COG0204; acyltransferase 4263541 yihG 3669589 yihG Shigella sonnei Ss046 acyltransferase YP_312787.1 4262609 R 300269 CDS YP_312788.1 74314369 3669590 4263905..4266691 1 NC_007384.1 3' --> 5' polymerase; 5' --> 3' and 3' --> 5' exonuclease; has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 4266691 polA 3669590 polA Shigella sonnei Ss046 DNA polymerase I YP_312788.1 4263905 D 300269 CDS YP_312789.2 161986408 3669591 complement(4267073..4267705) 1 NC_007384.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 4267705 engB 3669591 engB Shigella sonnei Ss046 ribosome biogenesis GTP-binding protein YsxC YP_312789.2 4267073 R 300269 CDS YP_312790.1 74314371 3669592 4268287..4268796 1 NC_007384.1 Code: S; COG: COG3078; hypothetical protein 4268796 yihI 3669592 yihI Shigella sonnei Ss046 hypothetical protein YP_312790.1 4268287 D 300269 CDS YP_312791.2 161986407 3669593 4268985..4270358 1 NC_007384.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4270358 hemN 3669593 hemN Shigella sonnei Ss046 coproporphyrinogen III oxidase YP_312791.2 4268985 D 300269 CDS YP_312792.1 74314373 3669594 complement(4270770..4272179) 1 NC_007384.1 sensor glnL; nitrogen regulator I, NRI; response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) 4272179 glnG 3669594 glnG Shigella sonnei Ss046 nitrogen regulation protein NR(I) YP_312792.1 4270770 R 300269 CDS YP_312793.1 74314374 3669595 complement(4272191..4273240) 1 NC_007384.1 nitrogen regulator II; NRII; sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) 4273240 glnL 3669595 glnL Shigella sonnei Ss046 nitrogen regulation protein NR(II) YP_312793.1 4272191 R 300269 CDS YP_312794.1 74314375 3669596 complement(4273414..4274823) 1 NC_007384.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase 4274823 glnA 3669596 glnA Shigella sonnei Ss046 glutamine synthetase YP_312794.1 4273414 R 300269 CDS YP_312795.1 74314376 3669597 4275322..4277019 1 NC_007384.1 Code: T; COG: COG1217; GTP-binding factor 4277019 yihK 3669597 yihK Shigella sonnei Ss046 GTP-binding factor YP_312795.1 4275322 D 300269 CDS YP_312796.1 74314377 3669598 4277124..4278470 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 4278470 3669598 SSON_4044 Shigella sonnei Ss046 IS4 orf YP_312796.1 4277124 D 300269 CDS YP_312797.1 74314378 3669599 complement(4278563..4279351) 1 NC_007384.1 Code: KG; COG: COG1349; DeoR-type transcriptional regulator 4279351 yihW 3669599 yihW Shigella sonnei Ss046 DeoR-type transcriptional regulator YP_312797.1 4278563 R 300269 CDS YP_312798.1 74314379 3669600 complement(4279526..4280872) 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 4280872 3669600 SSON_4046 Shigella sonnei Ss046 IS4 orf YP_312798.1 4279526 R 300269 CDS YP_312799.1 74314380 3669601 complement(4280922..4281725) 1 NC_007384.1 Code: G; COG: COG0524; kinase 4281725 yihV 3669601 yihV Shigella sonnei Ss046 kinase YP_312799.1 4280922 R 300269 CDS YP_312800.1 74314381 3669602 4281898..4282776 1 NC_007384.1 Code: I; COG: COG2084; dehydrogenase 4282776 yihU 3669602 yihU Shigella sonnei Ss046 dehydrogenase YP_312800.1 4281898 D 300269 CDS YP_312801.1 74314382 3669603 4282801..4283688 1 NC_007384.1 Code: G; COG: COG3684; aldolase 4283688 yihT 3669603 yihT Shigella sonnei Ss046 aldolase YP_312801.1 4282801 D 300269 CDS YP_312802.1 74314383 3669604 4283721..4284731 1 NC_007384.1 Code: ER; COG: COG1063; dehydrogenase 4284731 rspB 3669604 rspB Shigella sonnei Ss046 dehydrogenase YP_312802.1 4283721 D 300269 CDS YP_312803.1 74314384 3669605 4284801..4286234 1 NC_007384.1 transporter 4286234 3669605 SSON_4051 Shigella sonnei Ss046 transporter YP_312803.1 4284801 D 300269 CDS YP_312804.1 74314385 3669606 4286333..4287682 1 NC_007384.1 Code: GEPR; COG: COG0477; transport protein shikimate 4287682 shiA 3669606 shiA Shigella sonnei Ss046 transport protein shikimate YP_312804.1 4286333 D 300269 CDS YP_312805.1 74314386 3669607 4287672..4288559 1 NC_007384.1 hypothetical protein 4288559 3669607 SSON_4053 Shigella sonnei Ss046 hypothetical protein YP_312805.1 4287672 D 300269 CDS YP_312806.2 161986406 3669516 4288700..4289299 1 NC_007384.1 Code: R; COG: COG1011; phosphatase 4289299 yihX 3669516 yihX Shigella sonnei Ss046 phosphatase YP_312806.2 4288700 D 300269 CDS YP_312807.1 74314388 3669517 4289293..4290165 1 NC_007384.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 4290165 rbn 3669517 rbn Shigella sonnei Ss046 ribonuclease BN YP_312807.1 4289293 D 300269 CDS YP_312808.1 74314389 3669518 4290162..4290599 1 NC_007384.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 4290599 yihZ 3669518 yihZ Shigella sonnei Ss046 D-tyrosyl-tRNA(Tyr) deacylase YP_312808.1 4290162 D 300269 CDS YP_312809.1 74314390 3669519 4290596..4291585 1 NC_007384.1 Code: KR; COG: COG0454; acetyltransferase 4291585 yiiD 3669519 yiiD Shigella sonnei Ss046 acetyltransferase YP_312809.1 4290596 D 300269 CDS YP_312810.1 74314391 3669520 complement(4291647..4292150) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4292150 3669520 SSON_4058 Shigella sonnei Ss046 IS1 ORF YP_312810.1 4291647 R 300269 CDS YP_312811.1 74314392 3669521 4293217..4293459 1 NC_007384.1 hypothetical protein 4293459 yiiF 3669521 yiiF Shigella sonnei Ss046 hypothetical protein YP_312811.1 4293217 D 300269 CDS YP_312812.1 74314393 3669522 complement(4293789..4294718) 1 NC_007384.1 affects formate dehydrogenase-N; required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 4294718 fdhE 3669522 fdhE Shigella sonnei Ss046 formate dehydrogenase accessory protein FdhE YP_312812.1 4293789 R 300269 CDS YP_312813.1 74314394 3669523 complement(4294715..4295350) 1 NC_007384.1 cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma 4295350 fdoI 3669523 fdoI Shigella sonnei Ss046 formate dehydrogenase-O subunit gamma YP_312813.1 4294715 R 300269 CDS YP_312814.1 74314395 3669524 complement(4295347..4296249) 1 NC_007384.1 Code: C; COG: COG0437; formate dehydrogenase-O, iron-sulfur subunit 4296249 fdoH 3669524 fdoH Shigella sonnei Ss046 formate dehydrogenase-O, iron-sulfur subunit YP_312814.1 4295347 R 300269 CDS YP_312815.1 74314396 3669525 complement(4296262..4299312) 1 NC_007384.1 Code: C; COG: COG0243; formate dehydrogenase-O, major subunit 4299312 fdoG 3669525 fdoG Shigella sonnei Ss046 formate dehydrogenase-O, major subunit YP_312815.1 4296262 R 300269 CDS YP_312816.1 74314397 3669526 4299506..4300339 1 NC_007384.1 affects formate dehydrogenase-N; involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 4300339 fdhD 3669526 fdhD Shigella sonnei Ss046 formate dehydrogenase accessory protein YP_312816.1 4299506 D 300269 CDS YP_312817.1 74314398 3669528 4301497..4302000 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4302000 3669528 SSON_4066 Shigella sonnei Ss046 IS1 ORF YP_312817.1 4301497 D 300269 CDS YP_312818.1 74314399 3669529 complement(4302358..4304106) 1 NC_007384.1 repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system; frv operon regulatory protein 4304106 frvR 3669529 frvR Shigella sonnei Ss046 frv operon regulatory protein YP_312818.1 4302358 R 300269 CDS YP_312819.1 74314400 3669530 complement(4304106..4305176) 1 NC_007384.1 with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars; fructose-specific phosphotransferase system protein FrvX 4305176 frvX 3669530 frvX Shigella sonnei Ss046 fructose-specific phosphotransferase system protein FrvX YP_312819.1 4304106 R 300269 CDS YP_312820.1 74314401 3669531 complement(4305166..4306623) 1 NC_007384.1 Code: G; COG: COG1299; PTS system transporter subunits IIBC 4306623 frvB 3669531 frvB Shigella sonnei Ss046 PTS system transporter subunits IIBC YP_312820.1 4305166 R 300269 CDS YP_312821.1 74314402 3669532 complement(4306628..4307074) 1 NC_007384.1 with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system; fructose-like phosphotransferase system subunit EIIA 4307074 frvA 3669532 frvA Shigella sonnei Ss046 fructose-like phosphotransferase system subunit EIIA YP_312821.1 4306628 R 300269 CDS YP_312822.1 74314403 3669533 complement(4307375..4307689) 1 NC_007384.1 Code: S; COG: COG3254; hypothetical protein 4307689 yiiL 3669533 yiiL Shigella sonnei Ss046 hypothetical protein YP_312822.1 4307375 R 300269 CDS YP_312823.1 74314404 3669534 complement(4307699..4308523) 1 NC_007384.1 Code: G; COG: COG0235; rhamnulose-1-phosphate aldolase 4308523 rhaD 3669534 rhaD Shigella sonnei Ss046 rhamnulose-1-phosphate aldolase YP_312823.1 4307699 R 300269 CDS YP_312824.1 74314405 3669300 complement(4308765..4310024) 1 NC_007384.1 catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase 4310024 rhaA 3669300 rhaA Shigella sonnei Ss046 L-rhamnose isomerase YP_312824.1 4308765 R 300269 CDS YP_312825.1 74314406 3669301 complement(4310021..4311490) 1 NC_007384.1 catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase 4311490 rhaB 3669301 rhaB Shigella sonnei Ss046 rhamnulokinase YP_312825.1 4310021 R 300269 CDS YP_312826.1 74314407 3669302 4311778..4312614 1 NC_007384.1 activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 4312614 rhaS 3669302 rhaS Shigella sonnei Ss046 transcriptional activator RhaS YP_312826.1 4311778 D 300269 CDS YP_312827.1 74314408 3669304 complement(4313533..4314567) 1 NC_007384.1 transports L-rhamnose and L-lyxose into the cell; rhamnose-proton symporter 4314567 rhaT 3669304 rhaT Shigella sonnei Ss046 rhamnose-proton symporter YP_312827.1 4313533 R 300269 CDS YP_312828.1 74314409 3669305 4314852..4315472 1 NC_007384.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 4315472 sodA 3669305 sodA Shigella sonnei Ss046 superoxide dismutase YP_312828.1 4314852 D 300269 CDS YP_312829.2 161986405 3669306 4315732..4316715 1 NC_007384.1 transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 4316715 kdgT 3669306 kdgT Shigella sonnei Ss046 2-keto-3-deoxygluconate permease YP_312829.2 4315732 D 300269 CDS YP_312830.2 161986404 3669307 4316864..4317538 1 NC_007384.1 Code: S; COG: COG2258; hypothetical protein 4317538 yiiM 3669307 yiiM Shigella sonnei Ss046 hypothetical protein YP_312830.2 4316864 D 300269 CDS YP_312831.1 74314412 3669308 complement(4317644..4319017) 1 NC_007384.1 histidine protein kinase; part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein 4319017 cpxA 3669308 cpxA Shigella sonnei Ss046 two-component sensor protein YP_312831.1 4317644 R 300269 CDS YP_312832.1 74314413 3669309 complement(4319014..4319712) 1 NC_007384.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR 4319712 cpxR 3669309 cpxR Shigella sonnei Ss046 DNA-binding transcriptional regulator CpxR YP_312832.1 4319014 R 300269 CDS YP_312833.2 161986403 3669310 4319862..4320362 1 NC_007384.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; repressor CpxP 4320362 cpxP 3669310 cpxP Shigella sonnei Ss046 repressor CpxP YP_312833.2 4319862 D 300269 CDS YP_312834.1 74314415 3669311 4320510..4321412 1 NC_007384.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F 4321412 fieF 3669311 fieF Shigella sonnei Ss046 ferrous iron efflux protein F YP_312834.1 4320510 D 300269 CDS YP_312835.1 74314416 3669312 4321593..4322555 1 NC_007384.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 4322555 pfkA 3669312 pfkA Shigella sonnei Ss046 6-phosphofructokinase YP_312835.1 4321593 D 300269 CDS YP_312836.1 74314417 3669313 4322875..4323864 1 NC_007384.1 Code: P; COG: COG1613; sulfate transporter subunit 4323864 sbp 3669313 sbp Shigella sonnei Ss046 sulfate transporter subunit YP_312836.1 4322875 D 300269 CDS YP_312837.1 74314418 3669314 4323971..4324726 1 NC_007384.1 Code: I; COG: COG2134; CDP-diacylglycerol pyrophosphatase 4324726 cdh 3669314 cdh Shigella sonnei Ss046 CDP-diacylglycerol pyrophosphatase YP_312837.1 4323971 D 300269 CDS YP_312838.1 74314419 3669315 complement(4324781..4325548) 1 NC_007384.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 4325548 tpiA 3669315 tpiA Shigella sonnei Ss046 triosephosphate isomerase YP_312838.1 4324781 R 300269 CDS YP_312839.1 74314420 3669316 complement(4325656..4326255) 1 NC_007384.1 hypothetical protein 4326255 yiiQ 3669316 yiiQ Shigella sonnei Ss046 hypothetical protein YP_312839.1 4325656 R 300269 CDS YP_312840.1 74314421 3669317 4326356..4326796 1 NC_007384.1 Code: S; COG: COG3152; hypothetical protein 4326796 yiiR 3669317 yiiR Shigella sonnei Ss046 hypothetical protein YP_312840.1 4326356 D 300269 CDS YP_312841.1 74314422 3669318 4327008..4327307 1 NC_007384.1 Code: S; COG: COG3691; hypothetical protein 4327307 yiiS 3669318 yiiS Shigella sonnei Ss046 hypothetical protein YP_312841.1 4327008 D 300269 CDS YP_312842.1 74314423 3669319 4327334..4327762 1 NC_007384.1 with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 4327762 yiiT 3669319 yiiT Shigella sonnei Ss046 universal stress protein UspD YP_312842.1 4327334 D 300269 CDS YP_312843.1 74314424 3669281 complement(4327767..4328513) 1 NC_007384.1 Code: C; COG: COG1018; ferredoxin-NADP reductase 4328513 fpr 3669281 fpr Shigella sonnei Ss046 ferredoxin-NADP reductase YP_312843.1 4327767 R 300269 CDS YP_312844.1 74314425 3669282 complement(4328610..4329620) 1 NC_007384.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 4329620 glpX 3669282 glpX Shigella sonnei Ss046 fructose 1,6-bisphosphatase II YP_312844.1 4328610 R 300269 CDS YP_312845.1 74314426 3669283 complement(4329750..4331282) 1 NC_007384.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 4331282 glpK 3669283 glpK Shigella sonnei Ss046 glycerol kinase YP_312845.1 4329750 R 300269 CDS YP_312846.1 74314427 3669284 complement(4331284..4332129) 1 NC_007384.1 Code: G; COG: COG0580; facilitated diffusion of glycerol 4332129 glpF 3669284 glpF Shigella sonnei Ss046 facilitated diffusion of glycerol YP_312846.1 4331284 R 300269 CDS YP_312847.1 74314428 3669285 4332555..4332800 1 NC_007384.1 Code: S; COG: COG3074; hypothetical protein 4332800 yiiU 3669285 yiiU Shigella sonnei Ss046 hypothetical protein YP_312847.1 4332555 D 300269 CDS YP_312848.1 74314429 3669286 complement(4332885..4333370) 1 NC_007384.1 menaquinone biosynthesis, unknown; regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 4333370 menG 3669286 menG Shigella sonnei Ss046 ribonuclease activity regulator protein RraA YP_312848.1 4332885 R 300269 CDS YP_312849.1 74314430 3669287 complement(4333463..4334389) 1 NC_007384.1 1,4-dihydroxy-2-naphthoate --> dimethylmenaquinone; catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 4334389 menA 3669287 menA Shigella sonnei Ss046 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_312849.1 4333463 R 300269 CDS YP_312850.1 74314431 3669288 complement(4334456..4335787) 1 NC_007384.1 similar to chaperones; heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 4335787 hslU 3669288 hslU Shigella sonnei Ss046 ATP-dependent protease ATP-binding subunit HslU YP_312850.1 4334456 R 300269 CDS YP_312851.1 74314432 3669289 complement(4335797..4336327) 1 NC_007384.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 4336327 hslV 3669289 hslV Shigella sonnei Ss046 ATP-dependent protease peptidase subunit YP_312851.1 4335797 R 300269 CDS YP_312852.1 74314433 3669290 complement(4336420..4337379) 1 NC_007384.1 Code: D; COG: COG3087; cell division protein FtsN 4337379 ftsN 3669290 ftsN Shigella sonnei Ss046 cell division protein FtsN YP_312852.1 4336420 R 300269 CDS YP_312853.1 74314434 3669291 complement(4337471..4338496) 1 NC_007384.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR 4338496 cytR 3669291 cytR Shigella sonnei Ss046 DNA-binding transcriptional regulator CytR YP_312853.1 4337471 R 300269 CDS YP_312854.1 74314435 3669292 complement(4338652..4340850) 1 NC_007384.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 4340850 priA 3669292 priA Shigella sonnei Ss046 primosome assembly protein PriA YP_312854.1 4338652 R 300269 CDS YP_312855.1 74314436 3669293 4341053..4341265 1 NC_007384.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 4341265 rpmE 3669293 rpmE Shigella sonnei Ss046 50S ribosomal protein L31 YP_312855.1 4341053 D 300269 CDS YP_312856.1 74314437 3669294 4341425..4342309 1 NC_007384.1 hypothetical protein 4342309 3669294 SSON_4106 Shigella sonnei Ss046 hypothetical protein YP_312856.1 4341425 D 300269 CDS YP_312857.1 74314438 3669295 4342300..4342635 1 NC_007384.1 hypothetical protein 4342635 3669295 SSON_4107 Shigella sonnei Ss046 hypothetical protein YP_312857.1 4342300 D 300269 CDS YP_312858.1 74314439 3669296 4342722..4343894 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 4343894 3669296 SSON_4108 Shigella sonnei Ss046 IS21 ORF1 YP_312858.1 4342722 D 300269 CDS YP_312859.1 74314440 3669297 4343894..4344691 1 NC_007384.1 Code: L; COG: COG1484; IS21 ORF2 4344691 3669297 SSON_4109 Shigella sonnei Ss046 IS21 ORF2 YP_312859.1 4343894 D 300269 CDS YP_312860.1 74314441 3669298 4344785..4345696 1 NC_007384.1 hypothetical protein 4345696 3669298 SSON_4110 Shigella sonnei Ss046 hypothetical protein YP_312860.1 4344785 D 300269 CDS YP_312861.1 74314442 3669299 complement(4346927..4347535) 1 NC_007384.1 member of the NlpC/P60 superfamily of peptidases; peptidoglycan peptidase 4347535 yiiX 3669299 yiiX Shigella sonnei Ss046 peptidoglycan peptidase YP_312861.1 4346927 R 300269 CDS YP_312862.1 74314443 3669261 complement(4347719..4348036) 1 NC_007384.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ 4348036 metJ 3669261 metJ Shigella sonnei Ss046 transcriptional repressor protein MetJ YP_312862.1 4347719 R 300269 CDS YP_312863.1 74314444 3669262 4348313..4349473 1 NC_007384.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 4349473 metB 3669262 metB Shigella sonnei Ss046 cystathionine gamma-synthase YP_312863.1 4348313 D 300269 CDS YP_312864.1 74314445 3669263 4349476..4351908 1 NC_007384.1 homoserine dehydrogenase II; multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 4351908 metL 3669263 metL Shigella sonnei Ss046 bifunctional aspartate kinase II/homoserine dehydrogenase II YP_312864.1 4349476 D 300269 CDS YP_312865.1 74314446 3669264 4352257..4353147 1 NC_007384.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 4353147 metF 3669264 metF Shigella sonnei Ss046 5,10-methylenetetrahydrofolate reductase YP_312865.1 4352257 D 300269 CDS YP_312866.1 74314447 3669265 4353476..4355656 1 NC_007384.1 hydroperoxidase HPI(I); Code: P; COG: COG0376; catalase 4355656 katG 3669265 katG Shigella sonnei Ss046 catalase YP_312866.1 4353476 D 300269 CDS YP_312867.1 74314448 3669266 4355717..4356655 1 NC_007384.1 Code: GER; COG: COG0697; hypothetical protein 4356655 yijE 3669266 yijE Shigella sonnei Ss046 hypothetical protein YP_312867.1 4355717 D 300269 CDS YP_312868.1 74314449 3669267 complement(4356682..4357299) 1 NC_007384.1 Code: S; COG: COG3738; hypothetical protein 4357299 yijF 3669267 yijF Shigella sonnei Ss046 hypothetical protein YP_312868.1 4356682 R 300269 CDS YP_312869.2 161986402 3669268 complement(4357573..4358676) 1 NC_007384.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 4358676 gldA 3669268 gldA Shigella sonnei Ss046 glycerol dehydrogenase YP_312869.2 4357573 R 300269 CDS YP_312870.1 74314451 3669269 complement(4358687..4359349) 1 NC_007384.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 4359349 talC 3669269 talC Shigella sonnei Ss046 fructose-6-phosphate aldolase YP_312870.1 4358687 R 300269 CDS YP_312871.1 74314452 3669270 complement(4359361..4361496) 1 NC_007384.1 Code: G; COG: COG1080; PEP-protein phosphotransferase system enzyme I 4361496 ptsA 3669270 ptsA Shigella sonnei Ss046 PEP-protein phosphotransferase system enzyme I YP_312871.1 4359361 R 300269 CDS YP_312872.1 74314453 3669271 4362171..4363250 1 NC_007384.1 FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site; fructose-like permease EIIC subunit 2 4363250 frwC 3669271 frwC Shigella sonnei Ss046 fructose-like permease EIIC subunit 2 YP_312872.1 4362171 D 300269 CDS YP_312873.1 74314454 3669274 4365898..4366776 1 NC_007384.1 Code: O; COG: COG1180; pyruvate formate lyase II activase 4366776 pflC 3669274 pflC Shigella sonnei Ss046 pyruvate formate lyase II activase YP_312873.1 4365898 D 300269 CDS YP_312874.1 74314455 3669275 4366778..4367119 1 NC_007384.1 FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; fructose-like phosphotransferase EIIB subunit 3 4367119 frwD 3669275 frwD Shigella sonnei Ss046 fructose-like phosphotransferase EIIB subunit 3 YP_312874.1 4366778 D 300269 CDS YP_312875.1 74314456 3669276 complement(4367106..4367957) 1 NC_007384.1 Code: K; COG: COG2207; AraC family transcriptional regulator 4367957 yijO 3669276 yijO Shigella sonnei Ss046 AraC family transcriptional regulator YP_312875.1 4367106 R 300269 CDS YP_312876.1 74314457 3669277 complement(4368172..4369905) 1 NC_007384.1 Code: R; COG: COG2194; hypothetical protein 4369905 yijP 3669277 yijP Shigella sonnei Ss046 hypothetical protein YP_312876.1 4368172 R 300269 CDS YP_312877.1 74314458 3669278 complement(4370088..4372739) 1 NC_007384.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 4372739 ppc 3669278 ppc Shigella sonnei Ss046 phosphoenolpyruvate carboxylase YP_312877.1 4370088 R 300269 CDS YP_312878.1 74314459 3669279 complement(4373091..4374242) 1 NC_007384.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase 4374242 argE 3669279 argE Shigella sonnei Ss046 acetylornithine deacetylase YP_312878.1 4373091 R 300269 CDS YP_312879.1 74314460 3669280 4374396..4375400 1 NC_007384.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 4375400 argC 3669280 argC Shigella sonnei Ss046 N-acetyl-gamma-glutamyl-phosphate reductase YP_312879.1 4374396 D 300269 CDS YP_312880.2 161986401 3669130 4375411..4376184 1 NC_007384.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 4376184 argB 3669130 argB Shigella sonnei Ss046 acetylglutamate kinase YP_312880.2 4375411 D 300269 CDS YP_312881.1 74314462 3669131 4376245..4377618 1 NC_007384.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 4377618 argH 3669131 argH Shigella sonnei Ss046 argininosuccinate lyase YP_312881.1 4376245 D 300269 CDS YP_312882.1 74314463 3669132 4377885..4378802 1 NC_007384.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 4378802 oxyR 3669132 oxyR Shigella sonnei Ss046 DNA-binding transcriptional regulator OxyR YP_312882.1 4377885 D 300269 CDS YP_312883.2 161986400 3669133 complement(4378785..4380185) 1 NC_007384.1 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 4380185 udhA 3669133 udhA Shigella sonnei Ss046 soluble pyridine nucleotide transhydrogenase YP_312883.2 4378785 R 300269 CDS YP_312884.1 74314465 3669134 4380452..4381156 1 NC_007384.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 4381156 yijC 3669134 yijC Shigella sonnei Ss046 DNA-binding transcriptional repressor FabR YP_312884.1 4380452 D 300269 CDS YP_312885.1 74314466 3669135 4381156..4381515 1 NC_007384.1 hypothetical protein 4381515 yijD 3669135 yijD Shigella sonnei Ss046 hypothetical protein YP_312885.1 4381156 D 300269 CDS YP_312886.1 74314467 3669136 complement(4381555..4382655) 1 NC_007384.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 4382655 trmA 3669136 trmA Shigella sonnei Ss046 tRNA (uracil-5-)-methyltransferase YP_312886.1 4381555 R 300269 CDS YP_312887.1 74314468 3669137 4383024..4384868 1 NC_007384.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 4384868 btuB 3669137 btuB Shigella sonnei Ss046 vitamin B12/cobalamin outer membrane transporter YP_312887.1 4383024 D 300269 CDS YP_312888.2 161986399 3669138 4384813..4385670 1 NC_007384.1 required for biosynthesis of D-glutamate and peptidoglycan; converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 4385670 murI 3669138 murI Shigella sonnei Ss046 glutamate racemase YP_312888.2 4384813 D 300269 CDS YP_312889.1 74314470 3669143 4391188..4392216 1 NC_007384.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 4392216 murB 3669143 murB Shigella sonnei Ss046 UDP-N-acetylenolpyruvoylglucosamine reductase YP_312889.1 4391188 D 300269 CDS YP_312890.1 74314471 3669144 4392213..4393178 1 NC_007384.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 4393178 birA 3669144 birA Shigella sonnei Ss046 biotin--protein ligase YP_312890.1 4392213 D 300269 CDS YP_312891.1 74314472 3669115 complement(4393207..4394157) 1 NC_007384.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 4394157 coaA 3669115 coaA Shigella sonnei Ss046 pantothenate kinase YP_312891.1 4393207 R 300269 CDS YP_312892.1 74314473 3669116 complement(4394344..4394499) 1 NC_007384.1 hypothetical protein 4394499 3669116 SSON_4148 Shigella sonnei Ss046 hypothetical protein YP_312892.1 4394344 R 300269 CDS YP_312893.1 74314474 3669121 4395075..4396259 1 NC_007384.1 duplicate of tufA; EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4396259 tufB 3669121 tufB Shigella sonnei Ss046 elongation factor Tu YP_312893.1 4395075 D 300269 CDS YP_312894.1 74314475 3669122 4396489..4396872 1 NC_007384.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 4396872 secE 3669122 secE Shigella sonnei Ss046 preprotein translocase subunit SecE YP_312894.1 4396489 D 300269 CDS YP_312895.1 74314476 3669123 4396874..4397419 1 NC_007384.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 4397419 nusG 3669123 nusG Shigella sonnei Ss046 transcription antitermination protein NusG YP_312895.1 4396874 D 300269 CDS YP_312896.1 74314477 3669124 4397578..4398006 1 NC_007384.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 4398006 rplK 3669124 rplK Shigella sonnei Ss046 50S ribosomal protein L11 YP_312896.1 4397578 D 300269 CDS YP_312897.1 74314478 3669125 4398010..4398714 1 NC_007384.1 regulates synthesis of L1 and L11; in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 4398714 rplA 3669125 rplA Shigella sonnei Ss046 50S ribosomal protein L1 YP_312897.1 4398010 D 300269 CDS YP_312898.1 74314479 3669126 4399127..4399624 1 NC_007384.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 4399624 rplJ 3669126 rplJ Shigella sonnei Ss046 50S ribosomal protein L10 YP_312898.1 4399127 D 300269 CDS YP_312899.1 74314480 3669127 4399691..4400056 1 NC_007384.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 4400056 rplL 3669127 rplL Shigella sonnei Ss046 50S ribosomal protein L7/L12 YP_312899.1 4399691 D 300269 CDS YP_312900.1 74314481 3669128 4400376..4404404 1 NC_007384.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 4404404 rpoB 3669128 rpoB Shigella sonnei Ss046 DNA-directed RNA polymerase subunit beta YP_312900.1 4400376 D 300269 CDS YP_312901.1 74314482 3669129 4404481..4408704 1 NC_007384.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 4408704 rpoC 3669129 rpoC Shigella sonnei Ss046 DNA-directed RNA polymerase subunit beta' YP_312901.1 4404481 D 300269 CDS YP_312902.1 74314483 3669078 complement(4408946..4410079) 1 NC_007384.1 thiamin biosynthesis, thiazole moiety; in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH 4410079 thiH 3669078 thiH Shigella sonnei Ss046 thiamine biosynthesis protein ThiH YP_312902.1 4408946 R 300269 CDS YP_312903.2 161986398 3669079 complement(4410076..4410846) 1 NC_007384.1 thiamin biosynthesis, thiazole moiety; functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 4410846 thiG 3669079 thiG Shigella sonnei Ss046 thiazole synthase YP_312903.2 4410076 R 300269 CDS YP_312904.1 74314485 3669080 complement(4410848..4411048) 1 NC_007384.1 involved in thiamine biosynthesis; with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS 4411048 thiS 3669080 thiS Shigella sonnei Ss046 sulfur carrier protein ThiS YP_312904.1 4410848 R 300269 CDS YP_312905.2 161986397 3669081 complement(4411032..4411787) 1 NC_007384.1 thiamin biosynthesis, thiazole moiety; Code: H; COG: COG0476; hypothetical protein 4411787 thiF 3669081 thiF Shigella sonnei Ss046 hypothetical protein YP_312905.2 4411032 R 300269 CDS YP_312906.1 74314487 3669082 complement(4411780..4412415) 1 NC_007384.1 thiamin biosynthesis, thiazole moiety; catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase 4412415 thiE 3669082 thiE Shigella sonnei Ss046 thiamine-phosphate pyrophosphorylase YP_312906.1 4411780 R 300269 CDS YP_312907.1 74314488 3669083 complement(4412415..4414310) 1 NC_007384.1 thiamin biosynthesis, pyrimidine moiety; required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 4414310 thiC 3669083 thiC Shigella sonnei Ss046 thiamine biosynthesis protein ThiC YP_312907.1 4412415 R 300269 CDS YP_312908.1 74314489 3669084 complement(4414544..4415020) 1 NC_007384.1 binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor 4415020 yjaE 3669084 yjaE Shigella sonnei Ss046 anti-RNA polymerase sigma 70 factor YP_312908.1 4414544 R 300269 CDS YP_312909.1 74314490 3669085 4415115..4415888 1 NC_007384.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 4415888 nudC 3669085 nudC Shigella sonnei Ss046 NADH pyrophosphatase YP_312909.1 4415115 D 300269 CDS YP_312910.1 74314491 3669086 4415928..4416992 1 NC_007384.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 4416992 hemE 3669086 hemE Shigella sonnei Ss046 uroporphyrinogen decarboxylase YP_312910.1 4415928 D 300269 CDS YP_312911.2 161986396 3669087 4417002..4417673 1 NC_007384.1 deoxyinosine 3'endoduclease; Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 4417673 nfi 3669087 nfi Shigella sonnei Ss046 endonuclease V YP_312911.2 4417002 D 300269 CDS YP_312912.1 74314493 3669088 4417716..4418306 1 NC_007384.1 Code: S; COG: COG3068; hypothetical protein 4418306 yjaG 3669088 yjaG Shigella sonnei Ss046 hypothetical protein YP_312912.1 4417716 D 300269 CDS YP_312913.1 74314494 3669089 4418493..4418765 1 NC_007384.1 HU-2; histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 4418765 hupA 3669089 hupA Shigella sonnei Ss046 transcriptional regulator HU subunit alpha YP_312913.1 4418493 D 300269 CDS YP_312914.1 74314495 3669090 4418778..4419473 1 NC_007384.1 hypothetical protein 4419473 yjaH 3669090 yjaH Shigella sonnei Ss046 hypothetical protein YP_312914.1 4418778 D 300269 CDS YP_312915.2 161986395 3669091 complement(4419475..4419900) 1 NC_007384.1 Code: UNTP; COG: COG3678; zinc resistance protein 4419900 zraP 3669091 zraP Shigella sonnei Ss046 zinc resistance protein YP_312915.2 4419475 R 300269 CDS YP_312916.1 74314497 3669092 4420138..4421514 1 NC_007384.1 Code: T; COG: COG0642; sensor protein ZraS 4421514 hydH 3669092 hydH Shigella sonnei Ss046 sensor protein ZraS YP_312916.1 4420138 D 300269 CDS YP_312917.1 74314498 3669093 4421511..4422836 1 NC_007384.1 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 4422836 hydG 3669093 hydG Shigella sonnei Ss046 transcriptional regulatory protein ZraR YP_312917.1 4421511 D 300269 CDS YP_312918.1 74314499 3669094 complement(4422833..4424122) 1 NC_007384.1 GAR synthetase; catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 4424122 purD 3669094 purD Shigella sonnei Ss046 phosphoribosylamine--glycine ligase YP_312918.1 4422833 R 300269 CDS YP_312919.1 74314500 3669095 complement(4424134..4425723) 1 NC_007384.1 AICAR formyltransferase; IMP cyclohydrolase; involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 4425723 purH 3669095 purH Shigella sonnei Ss046 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_312919.1 4424134 R 300269 CDS YP_312920.1 74314501 3669064 complement(4431465..4431908) 1 NC_007384.1 Code: KR; COG: COG0454; hypothetical protein 4431908 yjaB 3669064 yjaB Shigella sonnei Ss046 hypothetical protein YP_312920.1 4431465 R 300269 CDS YP_312921.1 74314502 3669065 4432065..4432994 1 NC_007384.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 4432994 metA 3669065 metA Shigella sonnei Ss046 homoserine O-succinyltransferase YP_312921.1 4432065 D 300269 CDS YP_312922.1 74314503 3669066 4433263..4434705 1 NC_007384.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 4434705 aceB 3669066 aceB Shigella sonnei Ss046 malate synthase YP_312922.1 4433263 D 300269 CDS YP_312923.1 74314504 3669067 4434894..4436006 1 NC_007384.1 Code: C; COG: COG2224; isocitrate lyase 4436006 aceA 3669067 aceA Shigella sonnei Ss046 isocitrate lyase YP_312923.1 4434894 D 300269 CDS YP_312924.1 74314505 3669068 complement(4436210..4436713) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4436713 3669068 SSON_4188 Shigella sonnei Ss046 IS1 ORF YP_312924.1 4436210 R 300269 CDS YP_312925.2 161986394 3669069 complement(4438274..4439098) 1 NC_007384.1 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; IclR family transcriptional regulator 4439098 iclR 3669069 iclR Shigella sonnei Ss046 IclR family transcriptional regulator YP_312925.2 4438274 R 300269 CDS YP_312926.1 74314507 3669070 4439298..4442981 1 NC_007384.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 4442981 metH 3669070 metH Shigella sonnei Ss046 B12-dependent methionine synthase YP_312926.1 4439298 D 300269 CDS YP_312927.1 74314508 3669071 4443201..4444832 1 NC_007384.1 Code: P; COG: COG1283; alpha helix protein 4444832 yjbB 3669071 yjbB Shigella sonnei Ss046 alpha helix protein YP_312927.1 4443201 D 300269 CDS YP_312928.1 74314509 3669072 complement(4444923..4445612) 1 NC_007384.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E 4445612 pepE 3669072 pepE Shigella sonnei Ss046 peptidase E YP_312928.1 4444923 R 300269 CDS YP_312929.1 74314510 3669073 complement(4445995..4447110) 1 NC_007384.1 Code: ER; COG: COG1063; L-sorbose-1-P-reductase 4447110 sorE 3669073 sorE Shigella sonnei Ss046 L-sorbose-1-P-reductase YP_312929.1 4445995 R 300269 CDS YP_312930.1 74314511 3669074 complement(4447275..4448099) 1 NC_007384.1 Code: G; COG: COG3716; PTS system sorbose transporter subunit IID 4448099 sorM 3669074 sorM Shigella sonnei Ss046 PTS system sorbose transporter subunit IID YP_312930.1 4447275 R 300269 CDS YP_312931.1 74314512 3669075 complement(4448110..4448907) 1 NC_007384.1 Code: G; COG: COG3715; PTS system sorbose transporter subunit IIC 4448907 sorA 3669075 sorA Shigella sonnei Ss046 PTS system sorbose transporter subunit IIC YP_312931.1 4448110 R 300269 CDS YP_312932.1 74314513 3669077 complement(4449467..4449874) 1 NC_007384.1 Code: G; COG: COG2893; PTS system sorbose transporter subunit IIA 4449874 sorF 3669077 sorF Shigella sonnei Ss046 PTS system sorbose transporter subunit IIA YP_312932.1 4449467 R 300269 CDS YP_312933.1 74314514 3669042 complement(4449884..4450690) 1 NC_007384.1 Converts D-sorbitol-dphosphate to D-fructose-6-phosphate; sorbitol-6-phosphate 2-dehydrogenase 4450690 sorD 3669042 sorD Shigella sonnei Ss046 sorbitol-6-phosphate 2-dehydrogenase YP_312933.1 4449884 R 300269 CDS YP_312934.1 74314515 3669044 4451945..4452817 1 NC_007384.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 4452817 yjbC 3669044 yjbC Shigella sonnei Ss046 23S rRNA pseudouridine synthase F YP_312934.1 4451945 D 300269 CDS YP_312935.1 74314516 3669045 complement(4452950..4453222) 1 NC_007384.1 hypothetical protein 4453222 yjbD 3669045 yjbD Shigella sonnei Ss046 hypothetical protein YP_312935.1 4452950 R 300269 CDS YP_312936.1 74314517 3669046 complement(4453474..4454823) 1 NC_007384.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase 4454823 lysC 3669046 lysC Shigella sonnei Ss046 aspartate kinase YP_312936.1 4453474 R 300269 CDS YP_312937.1 74314518 3669047 4455348..4456997 1 NC_007384.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 4456997 pgi 3669047 pgi Shigella sonnei Ss046 glucose-6-phosphate isomerase YP_312937.1 4455348 D 300269 CDS YP_312938.1 74314519 3669048 4457459..4457701 1 NC_007384.1 hypothetical protein 4457701 yjbE 3669048 yjbE Shigella sonnei Ss046 hypothetical protein YP_312938.1 4457459 D 300269 CDS YP_312939.1 74314520 3669049 4457785..4458453 1 NC_007384.1 hypothetical protein 4458453 yjbF 3669049 yjbF Shigella sonnei Ss046 hypothetical protein YP_312939.1 4457785 D 300269 CDS YP_312940.1 74314521 3669050 4458450..4459187 1 NC_007384.1 hypothetical protein 4459187 yjbG 3669050 yjbG Shigella sonnei Ss046 hypothetical protein YP_312940.1 4458450 D 300269 CDS YP_312941.1 74314522 3669051 4459187..4461283 1 NC_007384.1 hypothetical protein 4461283 yjbH 3669051 yjbH Shigella sonnei Ss046 hypothetical protein YP_312941.1 4459187 D 300269 CDS YP_312942.1 74314523 3669052 4461878..4462288 1 NC_007384.1 Code: S; COG: COG3223; phosphate-starvation-inducible protein PsiE 4462288 yjbA 3669052 yjbA Shigella sonnei Ss046 phosphate-starvation-inducible protein PsiE YP_312942.1 4461878 D 300269 CDS YP_312943.1 74314524 3669053 complement(4462332..4463807) 1 NC_007384.1 xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter; D-xylose transporter XylE 4463807 xylE 3669053 xylE Shigella sonnei Ss046 D-xylose transporter XylE YP_312943.1 4462332 R 300269 CDS YP_312944.1 74314525 3669054 complement(4464179..4465069) 1 NC_007384.1 with MalKFE is involved in the transport of maltose into the cell; maltose ABC transporter permease 4465069 malG 3669054 malG Shigella sonnei Ss046 maltose ABC transporter permease YP_312944.1 4464179 R 300269 CDS YP_312945.1 74314526 3669055 complement(4465084..4466628) 1 NC_007384.1 with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein 4466628 malF 3669055 malF Shigella sonnei Ss046 maltose transporter membrane protein YP_312945.1 4465084 R 300269 CDS YP_312946.1 74314527 3669056 complement(4466782..4467972) 1 NC_007384.1 substrate recognition for transport and chemotaxis; functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter substrate-binding protein 4467972 malE 3669056 malE Shigella sonnei Ss046 maltose ABC transporter substrate-binding protein YP_312946.1 4466782 R 300269 CDS YP_312947.1 74314528 3669057 4468337..4469452 1 NC_007384.1 with malEFG is involved in import of maltose/maltodextrin; maltose ABC transporter ATP-binding protein 4469452 malK 3669057 malK Shigella sonnei Ss046 maltose ABC transporter ATP-binding protein YP_312947.1 4468337 D 300269 CDS YP_312948.1 74314529 3669058 4469524..4470864 1 NC_007384.1 maltose high-affinity receptor; porin involved in the transport of maltose and maltodextrins; maltoporin 4470864 lamB 3669058 lamB Shigella sonnei Ss046 maltoporin YP_312948.1 4469524 D 300269 CDS YP_312949.1 74314530 3669059 4471016..4471936 1 NC_007384.1 maltose regulon periplasmic protein 4471936 malM 3669059 malM Shigella sonnei Ss046 maltose regulon periplasmic protein YP_312949.1 4471016 D 300269 CDS YP_312950.1 74314531 3669060 complement(4473023..4474042) 1 NC_007384.1 Code: L; COG: COG3547; transposase 4474042 3669060 SSON_4216 Shigella sonnei Ss046 transposase YP_312950.1 4473023 R 300269 CDS YP_312951.1 74314532 3668944 complement(4475258..4476385) 1 NC_007384.1 Code: L; COG: COG3547; transposase 4476385 3668944 SSON_4218 Shigella sonnei Ss046 transposase YP_312951.1 4475258 R 300269 CDS YP_312952.2 161986393 3668945 4476929..4477426 1 NC_007384.1 catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 4477426 ubiC 3668945 ubiC Shigella sonnei Ss046 chorismate pyruvate lyase YP_312952.2 4476929 D 300269 CDS YP_312953.1 74314534 3668946 4477439..4478311 1 NC_007384.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 4478311 ubiA 3668946 ubiA Shigella sonnei Ss046 4-hydroxybenzoate octaprenyltransferase YP_312953.1 4477439 D 300269 CDS YP_312954.2 161986392 3668947 complement(4478466..4480889) 1 NC_007384.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 4480889 plsB 3668947 plsB Shigella sonnei Ss046 glycerol-3-phosphate acyltransferase YP_312954.2 4478466 R 300269 CDS YP_312955.1 74314536 3668948 4481060..4481428 1 NC_007384.1 Code: M; COG: COG0818; diacylglycerol kinase 4481428 dgkA 3668948 dgkA Shigella sonnei Ss046 diacylglycerol kinase YP_312955.1 4481060 D 300269 CDS YP_312956.1 74314537 3668949 4481538..4482146 1 NC_007384.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 4482146 lexA 3668949 lexA Shigella sonnei Ss046 LexA repressor YP_312956.1 4481538 D 300269 CDS YP_312957.2 161986391 3668950 4482219..4483544 1 NC_007384.1 Code: V; COG: COG0534; DNA-damage-inducible SOS response protein 4483544 dinF 3668950 dinF Shigella sonnei Ss046 DNA-damage-inducible SOS response protein YP_312957.2 4482219 D 300269 CDS YP_312958.1 74314539 3668951 4483660..4483869 1 NC_007384.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; stress-response protein 4483869 yjbJ 3668951 yjbJ Shigella sonnei Ss046 stress-response protein YP_312958.1 4483660 D 300269 CDS YP_312959.2 161986390 3668952 complement(4483911..4484426) 1 NC_007384.1 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor 4484426 yjbK 3668952 yjbK Shigella sonnei Ss046 zinc uptake transcriptional repressor YP_312959.2 4483911 R 300269 CDS YP_312960.1 74314541 3668953 4484744..4484998 1 NC_007384.1 hypothetical protein 4484998 yjbL 3668953 yjbL Shigella sonnei Ss046 hypothetical protein YP_312960.1 4484744 D 300269 CDS YP_312961.1 74314542 3668954 4485022..4485729 1 NC_007384.1 hypothetical protein 4485729 yjbM 3668954 yjbM Shigella sonnei Ss046 hypothetical protein YP_312961.1 4485022 D 300269 CDS YP_312962.1 74314543 3668955 4486092..4487129 1 NC_007384.1 Code: J; COG: COG0042; tRNA-dihydrouridine synthase A 4487129 yjbN 3668955 yjbN Shigella sonnei Ss046 tRNA-dihydrouridine synthase A YP_312962.1 4486092 D 300269 CDS YP_312963.2 161986389 3668956 4487263..4487505 1 NC_007384.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 4487505 pspG 3668956 pspG Shigella sonnei Ss046 phage shock protein G YP_312963.2 4487263 D 300269 CDS YP_312964.1 74314545 3668957 complement(4487671..4488654) 1 NC_007384.1 Code: CR; COG: COG0604; quinone oxidoreductase 4488654 qor 3668957 qor Shigella sonnei Ss046 quinone oxidoreductase YP_312964.1 4487671 R 300269 CDS YP_312965.1 74314546 3668958 4488737..4490152 1 NC_007384.1 unwinds double stranded DNA; replicative DNA helicase 4490152 dnaB 3668958 dnaB Shigella sonnei Ss046 replicative DNA helicase YP_312965.1 4488737 D 300269 CDS YP_312966.1 74314547 3668959 4490205..4491284 1 NC_007384.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 4491284 alr 3668959 alr Shigella sonnei Ss046 alanine racemase YP_312966.1 4490205 D 300269 CDS YP_312967.1 74314548 3668960 4491537..4492730 1 NC_007384.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 4492730 tyrB 3668960 tyrB Shigella sonnei Ss046 aromatic amino acid aminotransferase YP_312967.1 4491537 D 300269 CDS YP_312968.1 74314549 3668961 4493858..4494571 1 NC_007384.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 4494571 aphA 3668961 aphA Shigella sonnei Ss046 acid phosphatase/phosphotransferase YP_312968.1 4493858 D 300269 CDS YP_312969.1 74314550 3668962 4494682..4495098 1 NC_007384.1 Code: S; COG: COG0432; hypothetical protein 4495098 yjbQ 3668962 yjbQ Shigella sonnei Ss046 hypothetical protein YP_312969.1 4494682 D 300269 CDS YP_312970.1 74314551 3668773 4495102..4495458 1 NC_007384.1 Code: S; COG: COG2315; hypothetical protein 4495458 yjbR 3668773 yjbR Shigella sonnei Ss046 hypothetical protein YP_312970.1 4495102 D 300269 CDS YP_312971.1 74314552 3668774 complement(4495493..4498315) 1 NC_007384.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 4498315 uvrA 3668774 uvrA Shigella sonnei Ss046 excinuclease ABC subunit A YP_312971.1 4495493 R 300269 CDS YP_312972.1 74314553 3668775 4498569..4499105 1 NC_007384.1 binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 4499105 ssb 3668775 ssb Shigella sonnei Ss046 single-stranded DNA-binding protein YP_312972.1 4498569 D 300269 CDS YP_312973.1 74314554 3668777 4499914..4501500 1 NC_007384.1 Code: T; COG: COG4943; hypothetical protein 4501500 yjcC 3668777 yjcC Shigella sonnei Ss046 hypothetical protein YP_312973.1 4499914 D 300269 CDS YP_312974.1 74314555 3668778 complement(4501503..4501826) 1 NC_007384.1 regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS 4501826 soxS 3668778 soxS Shigella sonnei Ss046 DNA-binding transcriptional regulator SoxS YP_312974.1 4501503 R 300269 CDS YP_312975.1 74314556 3668779 4502202..4502705 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4502705 3668779 SSON_4243 Shigella sonnei Ss046 IS1 ORF YP_312975.1 4502202 D 300269 CDS YP_312976.1 74314557 3668781 complement(4504217..4505866) 1 NC_007384.1 Code: P; COG: COG0025; hypothetical protein 4505866 yjcE 3668781 yjcE Shigella sonnei Ss046 hypothetical protein YP_312976.1 4504217 R 300269 CDS YP_312977.1 74314558 3668782 complement(4506018..4507367) 1 NC_007384.1 Code: R; COG: COG2252; hypothetical protein 4507367 yjcD 3668782 yjcD Shigella sonnei Ss046 hypothetical protein YP_312977.1 4506018 R 300269 CDS YP_312978.1 74314559 3668783 complement(4507913..4508311) 1 NC_007384.1 Code: K; COG: COG0789; redox-sensing activator of soxS 4508311 soxR 3668783 soxR Shigella sonnei Ss046 redox-sensing activator of soxS YP_312978.1 4507913 R 300269 CDS YP_312979.1 74314560 3668784 complement(4508360..4508863) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4508863 3668784 SSON_4248 Shigella sonnei Ss046 IS1 ORF YP_312979.1 4508360 R 300269 CDS YP_312980.1 74314561 3668785 complement(4509248..4510897) 1 NC_007384.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease 4510897 actP 3668785 actP Shigella sonnei Ss046 acetate permease YP_312980.1 4509248 R 300269 CDS YP_312981.1 74314562 3668786 complement(4511407..4513365) 1 NC_007384.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 4513365 acs 3668786 acs Shigella sonnei Ss046 acetyl-CoA synthetase YP_312981.1 4511407 R 300269 CDS YP_312982.1 74314563 3668787 4513759..4515195 1 NC_007384.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 4515195 nrfA 3668787 nrfA Shigella sonnei Ss046 cytochrome c552 YP_312982.1 4513759 D 300269 CDS YP_312983.1 74314564 3668788 4515234..4515806 1 NC_007384.1 a penta-heme cytochrome c; part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 4515806 nrfB 3668788 nrfB Shigella sonnei Ss046 cytochrome c nitrite reductase pentaheme subunit YP_312983.1 4515234 D 300269 CDS YP_312984.1 74314565 3668789 4515803..4516474 1 NC_007384.1 Fe-S centers; Code: C; COG: COG0437; formate-dependent nitrite reductase 4516474 nrfC 3668789 nrfC Shigella sonnei Ss046 formate-dependent nitrite reductase YP_312984.1 4515803 D 300269 CDS YP_312985.1 74314566 3668790 4516471..4517427 1 NC_007384.1 Code: P; COG: COG3301; formate-dependent nitrate reductase complex transmembrane protein 4517427 nrfD 3668790 nrfD Shigella sonnei Ss046 formate-dependent nitrate reductase complex transmembrane protein YP_312985.1 4516471 D 300269 CDS YP_312986.1 74314567 3668791 4517507..4519165 1 NC_007384.1 possible assembly function; with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 4519165 nrfE 3668791 nrfE Shigella sonnei Ss046 heme lyase subunit NrfE YP_312986.1 4517507 D 300269 CDS YP_312987.1 74314568 3668753 4519158..4519541 1 NC_007384.1 part of formate-dependent nitrite reductase complex; Code: O; COG: COG3088; formate-dependent nitrite reductase complex subunit NrfF 4519541 nrfF 3668753 nrfF Shigella sonnei Ss046 formate-dependent nitrite reductase complex subunit NrfF YP_312987.1 4519158 D 300269 CDS YP_312988.1 74314569 3668754 4519538..4520134 1 NC_007384.1 Code: O; COG: COG4235; formate-dependent nitrite reductase complex subunit NrfG 4520134 nrfG 3668754 nrfG Shigella sonnei Ss046 formate-dependent nitrite reductase complex subunit NrfG YP_312988.1 4519538 D 300269 CDS YP_312989.1 74314570 3668755 4520476..4521789 1 NC_007384.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 4521789 gltP 3668755 gltP Shigella sonnei Ss046 glutamate/aspartate:proton symporter YP_312989.1 4520476 D 300269 CDS YP_312990.1 74314571 3668756 complement(4521868..4522557) 1 NC_007384.1 Code: R; COG: COG0790; hypothetical protein 4522557 yjcO 3668756 yjcO Shigella sonnei Ss046 hypothetical protein YP_312990.1 4521868 R 300269 CDS YP_312991.1 74314572 3668758 complement(4524996..4526462) 1 NC_007384.1 part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; outer membrane efflux protein MdtP 4526462 yjcP 3668758 yjcP Shigella sonnei Ss046 outer membrane efflux protein MdtP YP_312991.1 4524996 R 300269 CDS YP_312992.2 161986388 3668759 complement(4526459..4528510) 1 NC_007384.1 possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO 4528510 yjcQ 3668759 yjcQ Shigella sonnei Ss046 multidrug efflux system protein MdtO YP_312992.2 4526459 R 300269 CDS YP_312993.1 74314574 3668760 complement(4528510..4529541) 1 NC_007384.1 with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN 4529541 yjcR 3668760 yjcR Shigella sonnei Ss046 multidrug resistance protein MdtN YP_312993.1 4528510 R 300269 CDS YP_312994.1 74314575 3668761 complement(4529560..4529883) 1 NC_007384.1 formate dehydrogenase H 4529883 3668761 SSON_4264 Shigella sonnei Ss046 formate dehydrogenase H YP_312994.1 4529560 R 300269 CDS YP_312995.1 74314576 3668762 complement(4530044..4532041) 1 NC_007384.1 Code: Q; COG: COG2015; hypothetical protein 4532041 yjcS 3668762 yjcS Shigella sonnei Ss046 hypothetical protein YP_312995.1 4530044 R 300269 CDS YP_312996.1 74314577 3668763 4532282..4532599 1 NC_007384.1 Code: G; COG: COG0698; ribose 5-phosphate isomerase B 4532599 rpiB 3668763 rpiB Shigella sonnei Ss046 ribose 5-phosphate isomerase B YP_312996.1 4532282 D 300269 CDS YP_312997.1 74314578 3668764 4532668..4532997 1 NC_007384.1 hypothetical protein 4532997 3668764 SSON_4267 Shigella sonnei Ss046 hypothetical protein YP_312997.1 4532668 D 300269 CDS YP_312998.1 74314579 3668765 complement(4533144..4533902) 1 NC_007384.1 required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein 4533902 phnP 3668765 phnP Shigella sonnei Ss046 carbon-phosphorus lyase complex accessory protein YP_312998.1 4533144 R 300269 CDS YP_312999.1 74314580 3668766 complement(4533904..4534338) 1 NC_007384.1 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase 4534338 phnO 3668766 phnO Shigella sonnei Ss046 aminoalkylphosphonic acid N-acetyltransferase YP_312999.1 4533904 R 300269 CDS YP_313000.1 74314581 3668767 complement(4534325..4534882) 1 NC_007384.1 Code: P; COG: COG3709; ribose 1,5-bisphosphokinase 4534882 phnN 3668767 phnN Shigella sonnei Ss046 ribose 1,5-bisphosphokinase YP_313000.1 4534325 R 300269 CDS YP_313001.1 74314582 3668768 complement(4534882..4536018) 1 NC_007384.1 Code: P; COG: COG3454; phosphonate metabolism protein 4536018 phnM 3668768 phnM Shigella sonnei Ss046 phosphonate metabolism protein YP_313001.1 4534882 R 300269 CDS YP_313002.1 74314583 3668769 complement(4536015..4536695) 1 NC_007384.1 Code: P; COG: COG4778; ATP-binding protein of phosphonate transport 4536695 phnL 3668769 phnL Shigella sonnei Ss046 ATP-binding protein of phosphonate transport YP_313002.1 4536015 R 300269 CDS YP_313003.1 74314584 3668770 complement(4536806..4537564) 1 NC_007384.1 Code: P; COG: COG4107; phosphonate C-P lyase system protein PhnK 4537564 phnK 3668770 phnK Shigella sonnei Ss046 phosphonate C-P lyase system protein PhnK YP_313003.1 4536806 R 300269 CDS YP_313004.1 74314585 3668771 complement(4537561..4538406) 1 NC_007384.1 Code: P; COG: COG3627; phosphonate metabolism protein 4538406 phnJ 3668771 phnJ Shigella sonnei Ss046 phosphonate metabolism protein YP_313004.1 4537561 R 300269 CDS YP_313005.1 74314586 3668772 complement(4538399..4539463) 1 NC_007384.1 Code: P; COG: COG3626; phosphonate metabolism protein 4539463 phnI 3668772 phnI Shigella sonnei Ss046 phosphonate metabolism protein YP_313005.1 4538399 R 300269 CDS YP_313006.1 74314587 3668715 complement(4539463..4540047) 1 NC_007384.1 Code: P; COG: COG3625; carbon-phosphorus lyase complex subunit 4540047 phnH 3668715 phnH Shigella sonnei Ss046 carbon-phosphorus lyase complex subunit YP_313006.1 4539463 R 300269 CDS YP_313007.1 74314588 3668716 complement(4540044..4540496) 1 NC_007384.1 Code: P; COG: COG3624; phosphonate metabolism protein 4540496 phnG 3668716 phnG Shigella sonnei Ss046 phosphonate metabolism protein YP_313007.1 4540044 R 300269 CDS YP_313008.1 74314589 3668717 complement(4540497..4541222) 1 NC_007384.1 may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF 4541222 phnF 3668717 phnF Shigella sonnei Ss046 phosphonate metabolism transcriptional regulator PhnF YP_313008.1 4540497 R 300269 CDS YP_313009.1 74314590 3668718 complement(4541243..4542022) 1 NC_007384.1 Code: P; COG: COG3639; Pn transporter membrane channel protein 4542022 phnE 3668718 phnE Shigella sonnei Ss046 Pn transporter membrane channel protein YP_313009.1 4541243 R 300269 CDS YP_313010.1 74314591 3668719 complement(4542148..4543164) 1 NC_007384.1 Code: P; COG: COG3221; Pn transporter substrate binding protein 4543164 phnD 3668719 phnD Shigella sonnei Ss046 Pn transporter substrate binding protein YP_313010.1 4542148 R 300269 CDS YP_313011.1 74314592 3668720 complement(4543189..4543977) 1 NC_007384.1 Code: P; COG: COG3638; phosphonate/organophosphate ester transporter subunit 4543977 phnC 3668720 phnC Shigella sonnei Ss046 phosphonate/organophosphate ester transporter subunit YP_313011.1 4543189 R 300269 CDS YP_313012.1 74314593 3668722 complement(4544711..4545046) 1 NC_007384.1 Code: P; COG: COG2824; hypothetical protein 4545046 phnA 3668722 phnA Shigella sonnei Ss046 hypothetical protein YP_313012.1 4544711 R 300269 CDS YP_313013.1 74314594 3668723 4545459..4547687 1 NC_007384.1 Code: R; COG: COG0699; hypothetical protein 4547687 yjdA 3668723 yjdA Shigella sonnei Ss046 hypothetical protein YP_313013.1 4545459 D 300269 CDS YP_313014.1 74314595 3668724 4547717..4548550 1 NC_007384.1 hypothetical protein 4548550 yjcZ 3668724 yjcZ Shigella sonnei Ss046 hypothetical protein YP_313014.1 4547717 D 300269 CDS YP_313015.1 74314596 3668725 4548814..4550316 1 NC_007384.1 proline permease II; Code: GEPR; COG: COG0477; proline/glycine betaine transporter 4550316 proP 3668725 proP Shigella sonnei Ss046 proline/glycine betaine transporter YP_313015.1 4548814 D 300269 CDS YP_313016.1 74314597 3668726 complement(4550493..4551584) 1 NC_007384.1 Code: T; COG: COG0642; sensor protein BasS/PmrB 4551584 basS 3668726 basS Shigella sonnei Ss046 sensor protein BasS/PmrB YP_313016.1 4550493 R 300269 CDS YP_313017.1 74314598 3668727 complement(4551594..4552262) 1 NC_007384.1 member of 2-component regulatory system; response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR 4552262 basR 3668727 basR Shigella sonnei Ss046 DNA-binding transcriptional regulator BasR YP_313017.1 4551594 R 300269 CDS YP_313018.1 74314599 3668728 complement(4552259..4553932) 1 NC_007384.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; cell division protein 4553932 yjdB 3668728 yjdB Shigella sonnei Ss046 cell division protein YP_313018.1 4552259 R 300269 CDS YP_313019.1 74314600 3668729 complement(4554006..4555343) 1 NC_007384.1 Code: E; COG: COG0531; arginine:agmatin antiporter 4555343 yjdE 3668729 yjdE Shigella sonnei Ss046 arginine:agmatin antiporter YP_313019.1 4554006 R 300269 CDS YP_313020.1 74314601 3668730 complement(4555480..4556241) 1 NC_007384.1 Code: K; COG: COG2207; AraC family transcriptional regulator 4556241 adiY 3668730 adiY Shigella sonnei Ss046 AraC family transcriptional regulator YP_313020.1 4555480 R 300269 CDS YP_313021.1 74314602 3668731 complement(4556566..4558836) 1 NC_007384.1 Code: E; COG: COG1982; biodegradative arginine decarboxylase 4558836 adiA 3668731 adiA Shigella sonnei Ss046 biodegradative arginine decarboxylase YP_313021.1 4556566 R 300269 CDS YP_313022.1 74314603 3668732 complement(4559032..4559940) 1 NC_007384.1 Code: K; COG: COG2207; DNA-binding transcriptional regulator MelR 4559940 melR 3668732 melR Shigella sonnei Ss046 DNA-binding transcriptional regulator MelR YP_313022.1 4559032 R 300269 CDS YP_313023.1 74314604 3668733 4560223..4561578 1 NC_007384.1 Code: G; COG: COG1486; alpha-galactosidase 4561578 melA 3668733 melA Shigella sonnei Ss046 alpha-galactosidase YP_313023.1 4560223 D 300269 CDS YP_313024.2 161986387 3668696 4562949..4563854 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 4563854 3668696 SSON_4296 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_313024.2 4562949 D 300269 CDS YP_313025.1 74314606 3668697 4564850..4565353 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4565353 3668697 SSON_4297 Shigella sonnei Ss046 IS1 ORF YP_313025.1 4564850 D 300269 CDS YP_313026.1 74314607 3668698 complement(4565288..4565983) 1 NC_007384.1 Code: S; COG: COG3647; hypothetical protein 4565983 yjdF 3668698 yjdF Shigella sonnei Ss046 hypothetical protein YP_313026.1 4565288 R 300269 CDS YP_313027.1 74314608 3668699 complement(4566106..4567752) 1 NC_007384.1 fumarate hydratase Class I; anaerobic isozyme; Code: C; COG: COG1951; fumarase B 4567752 fumB 3668699 fumB Shigella sonnei Ss046 fumarase B YP_313027.1 4566106 R 300269 CDS YP_313028.1 74314609 3668700 complement(4567830..4569170) 1 NC_007384.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter 4569170 dcuB 3668700 dcuB Shigella sonnei Ss046 anaerobic C4-dicarboxylate transporter YP_313028.1 4567830 R 300269 CDS YP_313029.1 74314610 3668701 complement(4569741..4570460) 1 NC_007384.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR 4570460 yjdG 3668701 yjdG Shigella sonnei Ss046 DNA-binding transcriptional activator DcuR YP_313029.1 4569741 R 300269 CDS YP_313030.1 74314611 3668702 complement(4570457..4572088) 1 NC_007384.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS 4572088 yjdH 3668702 yjdH Shigella sonnei Ss046 sensory histidine kinase DcuS YP_313030.1 4570457 R 300269 CDS YP_313031.1 74314612 3668703 4572269..4572499 1 NC_007384.1 Code: S; COG: COG3592; hypothetical protein 4572499 yjdI 3668703 yjdI Shigella sonnei Ss046 hypothetical protein YP_313031.1 4572269 D 300269 CDS YP_313032.1 74314613 3668704 4572511..4572783 1 NC_007384.1 Code: R; COG: COG2388; hypothetical protein 4572783 yjdJ 3668704 yjdJ Shigella sonnei Ss046 hypothetical protein YP_313032.1 4572511 D 300269 CDS YP_313033.1 74314614 3668705 4573010..4573306 1 NC_007384.1 hypothetical protein 4573306 yjdK 3668705 yjdK Shigella sonnei Ss046 hypothetical protein YP_313033.1 4573010 D 300269 CDS YP_313034.1 74314615 3668706 complement(4573626..4575143) 1 NC_007384.1 heat shock protein; class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 4575143 lysU 3668706 lysU Shigella sonnei Ss046 lysyl-tRNA synthetase YP_313034.1 4573626 R 300269 CDS YP_313035.1 74314616 3668707 complement(4575380..4576837) 1 NC_007384.1 Code: E; COG: COG3104; peptide transporter 4576837 yjdL 3668707 yjdL Shigella sonnei Ss046 peptide transporter YP_313035.1 4575380 R 300269 CDS YP_313036.1 74314617 3668709 complement(4577199..4577912) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 4577912 3668709 SSON_4309 Shigella sonnei Ss046 IS600 ORF2 YP_313036.1 4577199 R 300269 CDS YP_313037.1 74314618 3668710 complement(4578053..4578355) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 4578355 3668710 SSON_4310 Shigella sonnei Ss046 IS600 ORF1 YP_313037.1 4578053 R 300269 CDS YP_313038.2 161986386 3668711 complement(4579314..4580219) 1 NC_007384.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 4580219 3668711 SSON_4311 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_313038.2 4579314 R 300269 CDS YP_313039.1 74314620 3668712 4582185..4582487 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 4582487 3668712 SSON_4312 Shigella sonnei Ss046 IS600 ORF1 YP_313039.1 4582185 D 300269 CDS YP_313040.1 74314621 3668713 4582628..4583341 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 4583341 3668713 SSON_4313 Shigella sonnei Ss046 IS600 ORF2 YP_313040.1 4582628 D 300269 CDS YP_313041.1 74314622 3668714 4583428..4584774 1 NC_007384.1 Code: L; COG: COG3385; IS4 orf 4584774 3668714 SSON_4314 Shigella sonnei Ss046 IS4 orf YP_313041.1 4583428 D 300269 CDS YP_313042.1 74314623 3668621 complement(4588467..4589066) 1 NC_007384.1 Code: K; COG: COG1309; transcriptional regulator 4589066 yjdC 3668621 yjdC Shigella sonnei Ss046 transcriptional regulator YP_313042.1 4588467 R 300269 CDS YP_313043.1 74314624 3668622 complement(4589079..4590776) 1 NC_007384.1 copper tolerance; two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein 4590776 dipZ 3668622 dipZ Shigella sonnei Ss046 thiol:disulfide interchange protein YP_313043.1 4589079 R 300269 CDS YP_313044.1 74314625 3668623 complement(4590752..4591090) 1 NC_007384.1 cytochrome c biogenesis; copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA 4591090 cutA 3668623 cutA Shigella sonnei Ss046 divalent-cation tolerance protein CutA YP_313044.1 4590752 R 300269 CDS YP_313045.1 74314626 3668624 complement(4591206..4592507) 1 NC_007384.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 4592507 dcuA 3668624 dcuA Shigella sonnei Ss046 anaerobic C4-dicarboxylate transporter YP_313045.1 4591206 R 300269 CDS YP_313046.1 74314627 3668625 complement(4592625..4594106) 1 NC_007384.1 aspartase; catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 4594106 aspA 3668625 aspA Shigella sonnei Ss046 aspartate ammonia-lyase YP_313046.1 4592625 R 300269 CDS YP_313047.1 74314628 3668626 4594398..4594868 1 NC_007384.1 Protein affecting phage T7 exclusion by the F plasmid; F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 4594868 fxsA 3668626 fxsA Shigella sonnei Ss046 FxsA protein YP_313047.1 4594398 D 300269 CDS YP_313048.1 74314629 3668627 complement(4594890..4596146) 1 NC_007384.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function; hypothetical protein 4596146 yjeH 3668627 yjeH Shigella sonnei Ss046 hypothetical protein YP_313048.1 4594890 R 300269 CDS YP_313049.1 74314630 3668628 4596422..4596715 1 NC_007384.1 10 kDa chaperone binds to Hsp60 in presence of Mg-ATP; suppressing its ATPase activity; 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 4596715 groES 3668628 groES Shigella sonnei Ss046 co-chaperonin GroES YP_313049.1 4596422 D 300269 CDS YP_313050.1 74314631 3668629 4596759..4598405 1 NC_007384.1 chaperone Hsp60; peptide-dependent ATPase; heat shock protein; 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 4598405 groEL 3668629 groEL Shigella sonnei Ss046 molecular chaperone GroEL YP_313050.1 4596759 D 300269 CDS YP_313051.1 74314632 3668630 4598510..4598896 1 NC_007384.1 hypothetical protein 4598896 yjeI 3668630 yjeI Shigella sonnei Ss046 hypothetical protein YP_313051.1 4598510 D 300269 CDS YP_313052.1 74314633 3668631 complement(4599099..4599866) 1 NC_007384.1 hypothetical protein 4599866 yjeJ 3668631 yjeJ Shigella sonnei Ss046 hypothetical protein YP_313052.1 4599099 R 300269 CDS YP_313053.1 74314634 3668632 4600133..4600636 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4600636 3668632 SSON_4329 Shigella sonnei Ss046 IS1 ORF YP_313053.1 4600133 D 300269 CDS YP_313054.1 74314635 3668633 complement(4601135..4602163) 1 NC_007384.1 Code: E; COG: COG1509; hypothetical protein 4602163 yjeK 3668633 yjeK Shigella sonnei Ss046 hypothetical protein YP_313054.1 4601135 R 300269 CDS YP_313055.1 74314636 3668634 4602205..4602771 1 NC_007384.1 EF-P; Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 4602771 efp 3668634 efp Shigella sonnei Ss046 elongation factor P YP_313055.1 4602205 D 300269 CDS YP_313056.1 74314637 3668635 4602823..4602948 1 NC_007384.1 acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex; entericidin A 4602948 3668635 SSON_4332 Shigella sonnei Ss046 entericidin A YP_313056.1 4602823 D 300269 CDS YP_313057.1 74314638 3668489 4603059..4603205 1 NC_007384.1 Code: S; COG: COG5510; entericidin B 4603205 3668489 SSON_4333 Shigella sonnei Ss046 entericidin B YP_313057.1 4603059 D 300269 CDS YP_313058.1 74314639 3668491 complement(4603694..4604227) 1 NC_007384.1 lipocalin; lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc 4604227 blc 3668491 blc Shigella sonnei Ss046 outer membrane lipoprotein Blc YP_313058.1 4603694 R 300269 CDS YP_313059.1 74314640 3668492 complement(4604316..4605449) 1 NC_007384.1 Code: V; COG: COG1680; beta-lactamase 4605449 ampC 3668492 ampC Shigella sonnei Ss046 beta-lactamase YP_313059.1 4604316 R 300269 CDS YP_313060.1 74314641 3668493 complement(4605512..4605871) 1 NC_007384.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 4605871 frdD 3668493 frdD Shigella sonnei Ss046 fumarate reductase subunit D YP_313060.1 4605512 R 300269 CDS YP_313061.1 74314642 3668494 complement(4605882..4606277) 1 NC_007384.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C 4606277 frdC 3668494 frdC Shigella sonnei Ss046 fumarate reductase subunit C YP_313061.1 4605882 R 300269 CDS YP_313062.1 74314643 3668495 complement(4606288..4607022) 1 NC_007384.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit 4607022 frdB 3668495 frdB Shigella sonnei Ss046 fumarate reductase iron-sulfur subunit YP_313062.1 4606288 R 300269 CDS YP_313063.1 74314644 3668496 complement(4607015..4608823) 1 NC_007384.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 4608823 frdA 3668496 frdA Shigella sonnei Ss046 fumarate reductase flavoprotein subunit YP_313063.1 4607015 R 300269 CDS YP_313064.2 161986385 3668497 4609148..4610125 1 NC_007384.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 4610125 yjeA 3668497 yjeA Shigella sonnei Ss046 lysyl-tRNA synthetase YP_313064.2 4609148 D 300269 CDS YP_313065.1 74314646 3668498 4610760..4611263 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4611263 3668498 SSON_4342 Shigella sonnei Ss046 IS1 ORF YP_313065.1 4610760 D 300269 CDS YP_313066.1 74314647 3668500 complement(4612774..4616097) 1 NC_007384.1 Code: M; COG: COG3264; hypothetical protein 4616097 yjeP 3668500 yjeP Shigella sonnei Ss046 hypothetical protein YP_313066.1 4612774 R 300269 CDS YP_313067.1 74314648 3668501 complement(4616119..4617087) 1 NC_007384.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 4617087 psd 3668501 psd Shigella sonnei Ss046 phosphatidylserine decarboxylase YP_313067.1 4616119 R 300269 CDS YP_313068.2 161986384 3668502 complement(4617184..4618236) 1 NC_007384.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 4618236 yjeQ 3668502 yjeQ Shigella sonnei Ss046 ribosome-associated GTPase YP_313068.2 4617184 R 300269 CDS YP_313069.2 161986383 3668503 4618331..4618876 1 NC_007384.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4618876 yjeR 3668503 yjeR Shigella sonnei Ss046 oligoribonuclease YP_313069.2 4618331 D 300269 CDS YP_313070.1 74314652 3668472 complement(4619776..4620915) 1 NC_007384.1 Code: C; COG: COG1600; hypothetical protein 4620915 yjeS 3668472 yjeS Shigella sonnei Ss046 hypothetical protein YP_313070.1 4619776 R 300269 CDS YP_313071.1 74314651 3668471 4620914..4622461 1 NC_007384.1 Code: G; COG: COG0063; hypothetical protein 4622461 yjeF 3668471 yjeF Shigella sonnei Ss046 hypothetical protein YP_313071.1 4620914 D 300269 CDS YP_313072.1 74314653 3668473 4622433..4622894 1 NC_007384.1 possibly involved in cell wall synthesis; ATPase 4622894 yjeE 3668473 yjeE Shigella sonnei Ss046 ATPase YP_313072.1 4622433 D 300269 CDS YP_313073.1 74314654 3668474 4622913..4624250 1 NC_007384.1 a murein hydrolase; Code: M; COG: COG0860; N-acetylmuramoyl-L-alanine amidase 4624250 amiB 3668474 amiB Shigella sonnei Ss046 N-acetylmuramoyl-L-alanine amidase YP_313073.1 4622913 D 300269 CDS YP_313074.1 74314655 3668475 4624260..4626107 1 NC_007384.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 4626107 mutL 3668475 mutL Shigella sonnei Ss046 DNA mismatch repair protein YP_313074.1 4624260 D 300269 CDS YP_313075.1 74314656 3668476 4626100..4627050 1 NC_007384.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 4627050 miaA 3668476 miaA Shigella sonnei Ss046 tRNA delta(2)-isopentenylpyrophosphate transferase YP_313075.1 4626100 D 300269 CDS YP_313076.1 74314657 3668477 4627136..4627444 1 NC_007384.1 Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 4627444 hfq 3668477 hfq Shigella sonnei Ss046 RNA-binding protein Hfq YP_313076.1 4627136 D 300269 CDS YP_313077.1 74314658 3668478 4627521..4628801 1 NC_007384.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; GTPase HflX 4628801 hflX 3668478 hflX Shigella sonnei Ss046 GTPase HflX YP_313077.1 4627521 D 300269 CDS YP_313078.1 74314659 3668479 4628887..4630146 1 NC_007384.1 with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 4630146 hflK 3668479 hflK Shigella sonnei Ss046 FtsH protease regulator HflK YP_313078.1 4628887 D 300269 CDS YP_313079.1 74314660 3668480 4630149..4631153 1 NC_007384.1 with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 4631153 hflC 3668480 hflC Shigella sonnei Ss046 FtsH protease regulator HflC YP_313079.1 4630149 D 300269 CDS YP_313080.1 74314661 3668481 4631235..4631432 1 NC_007384.1 Code: S; COG: COG3242; hypothetical protein 4631432 yjeT 3668481 yjeT Shigella sonnei Ss046 hypothetical protein YP_313080.1 4631235 D 300269 CDS YP_313081.1 74314662 3668482 4631536..4632834 1 NC_007384.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 4632834 purA 3668482 purA Shigella sonnei Ss046 adenylosuccinate synthetase YP_313081.1 4631536 D 300269 CDS YP_313082.1 74314663 3668483 4633039..4633464 1 NC_007384.1 negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 4633464 yjeB 3668483 yjeB Shigella sonnei Ss046 transcriptional repressor NsrR YP_313082.1 4633039 D 300269 CDS YP_313083.2 161986382 3668484 4633503..4635944 1 NC_007384.1 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 4635944 vacB 3668484 vacB Shigella sonnei Ss046 exoribonuclease R YP_313083.2 4633503 D 300269 CDS YP_313084.1 74314665 3668485 4636124..4636855 1 NC_007384.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 4636855 yjfH 3668485 yjfH Shigella sonnei Ss046 23S rRNA (guanosine-2'-O-)-methyltransferase YP_313084.1 4636124 D 300269 CDS YP_313085.1 74314666 3668486 4637175..4637678 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4637678 3668486 SSON_4366 Shigella sonnei Ss046 IS1 ORF YP_313085.1 4637175 D 300269 CDS YP_313086.1 74314667 3668488 4638277..4639440 1 NC_007384.1 Code: E; COG: COG0754; synthetase/amidase 4639440 yjfC 3668488 yjfC Shigella sonnei Ss046 synthetase/amidase YP_313086.1 4638277 D 300269 CDS YP_313087.1 74314668 3668411 4639509..4641149 1 NC_007384.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 4641149 aidB 3668411 aidB Shigella sonnei Ss046 isovaleryl CoA dehydrogenase YP_313087.1 4639509 D 300269 CDS YP_313088.1 74314669 3668412 complement(4641266..4641568) 1 NC_007384.1 hypothetical protein 4641568 yjfN 3668412 yjfN Shigella sonnei Ss046 hypothetical protein YP_313088.1 4641266 R 300269 CDS YP_313089.2 161986381 3668413 complement(4641690..4642019) 1 NC_007384.1 in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility; biofilm stress and motility protein A 4642019 yjfO 3668413 yjfO Shigella sonnei Ss046 biofilm stress and motility protein A YP_313089.2 4641690 R 300269 CDS YP_313090.1 74314671 3668414 4642201..4642950 1 NC_007384.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 4642950 yjfP 3668414 yjfP Shigella sonnei Ss046 esterase YP_313090.1 4642201 D 300269 CDS YP_313091.1 74314672 3668415 complement(4642947..4643702) 1 NC_007384.1 negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR 4643702 yjfQ 3668415 yjfQ Shigella sonnei Ss046 transcriptional repressor UlaR YP_313091.1 4642947 R 300269 CDS YP_313092.1 74314673 3668416 complement(4643810..4644880) 1 NC_007384.1 Code: R; COG: COG2220; L-ascorbate 6-phosphate lactonase 4644880 yjfR 3668416 yjfR Shigella sonnei Ss046 L-ascorbate 6-phosphate lactonase YP_313092.1 4643810 R 300269 CDS YP_313093.1 74314674 3668418 4646643..4646948 1 NC_007384.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIB 4646948 sgaB 3668418 sgaB Shigella sonnei Ss046 PTS system L-ascorbate-specific transporter subunit IIB YP_313093.1 4646643 D 300269 CDS YP_313094.1 74314675 3668419 4646958..4647422 1 NC_007384.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIA 4647422 ptxA 3668419 ptxA Shigella sonnei Ss046 PTS system L-ascorbate-specific transporter subunit IIA YP_313094.1 4646958 D 300269 CDS YP_313095.1 74314676 3668420 4647436..4648086 1 NC_007384.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 4648086 ulaD 3668420 ulaD Shigella sonnei Ss046 3-keto-L-gulonate-6-phosphate decarboxylase YP_313095.1 4647436 D 300269 CDS YP_313096.1 74314677 3668421 4648096..4648950 1 NC_007384.1 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 4648950 sgaU 3668421 sgaU Shigella sonnei Ss046 L-xylulose 5-phosphate 3-epimerase YP_313096.1 4648096 D 300269 CDS YP_313097.1 74314678 3668422 4648950..4649636 1 NC_007384.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4649636 sgaE 3668422 sgaE Shigella sonnei Ss046 L-ribulose-5-phosphate 4-epimerase YP_313097.1 4648950 D 300269 CDS YP_313098.1 74314679 3668423 4649733..4650284 1 NC_007384.1 Code: S; COG: COG3477; hypothetical protein 4650284 yagU 3668423 yagU Shigella sonnei Ss046 hypothetical protein YP_313098.1 4649733 D 300269 CDS YP_313099.1 74314680 3668424 complement(4650396..4650674) 1 NC_007384.1 hypothetical protein 4650674 yjfY 3668424 yjfY Shigella sonnei Ss046 hypothetical protein YP_313099.1 4650396 R 300269 CDS YP_313100.1 74314681 3668425 4651001..4651396 1 NC_007384.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 4651396 rpsF 3668425 rpsF Shigella sonnei Ss046 30S ribosomal protein S6 YP_313100.1 4651001 D 300269 CDS YP_313101.1 74314682 3668426 4651403..4651717 1 NC_007384.1 binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 4651717 priB 3668426 priB Shigella sonnei Ss046 primosomal replication protein N YP_313101.1 4651403 D 300269 CDS YP_313102.1 74314683 3668427 4651722..4651949 1 NC_007384.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4651949 rpsR 3668427 rpsR Shigella sonnei Ss046 30S ribosomal protein S18 YP_313102.1 4651722 D 300269 CDS YP_313103.1 74314684 3668428 4651991..4652440 1 NC_007384.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4652440 rplI 3668428 rplI Shigella sonnei Ss046 50S ribosomal protein L9 YP_313103.1 4651991 D 300269 CDS YP_313104.1 74314685 3668429 complement(4652552..4653523) 1 NC_007384.1 Code: G; COG: COG1638; dicarboxylate-binding periplasmic protein 4653523 3668429 SSON_4387 Shigella sonnei Ss046 dicarboxylate-binding periplasmic protein YP_313104.1 4652552 R 300269 CDS YP_313105.1 74314686 3668315 complement(4654009..4654512) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4654512 3668315 SSON_4389 Shigella sonnei Ss046 IS1 ORF YP_313105.1 4654009 R 300269 CDS YP_313106.1 74314687 3668316 4654786..4655112 1 NC_007384.1 Code: K; COG: COG1309; hypothetical protein 4655112 ytfA 3668316 ytfA Shigella sonnei Ss046 hypothetical protein YP_313106.1 4654786 D 300269 CDS YP_313107.1 74314688 3668317 complement(4655096..4655770) 1 NC_007384.1 Code: M; COG: COG3061; hypothetical protein 4655770 ytfB 3668317 ytfB Shigella sonnei Ss046 hypothetical protein YP_313107.1 4655096 R 300269 CDS YP_313108.1 74314689 3668319 4656882..4658294 1 NC_007384.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 4658294 cycA 3668319 cycA Shigella sonnei Ss046 D-alanine/D-serine/glycine permease YP_313108.1 4656882 D 300269 CDS YP_313109.1 74314690 3668320 complement(4658339..4659001) 1 NC_007384.1 Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein 4659001 ytfE 3668320 ytfE Shigella sonnei Ss046 iron-sulfur cluster repair di-iron protein YP_313109.1 4658339 R 300269 CDS YP_313110.1 74314691 3668321 complement(4659109..4660083) 1 NC_007384.1 Code: GER; COG: COG0697; transmembrane subunit 4660083 ytfF 3668321 ytfF Shigella sonnei Ss046 transmembrane subunit YP_313110.1 4659109 R 300269 CDS YP_313111.1 74314693 3668323 complement(4660182..4661042) 1 NC_007384.1 Code: MG; COG: COG0702; oxidoreductase 4661042 ytfG 3668323 ytfG Shigella sonnei Ss046 oxidoreductase YP_313111.1 4660182 R 300269 CDS YP_313112.1 74314692 3668322 4661041..4661511 1 NC_007384.1 Code: K; COG: COG1733; hypothetical protein 4661511 ytfH 3668322 ytfH Shigella sonnei Ss046 hypothetical protein YP_313112.1 4661041 D 300269 CDS YP_313113.1 74314694 3668324 complement(4661629..4663572) 1 NC_007384.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein 4663572 cpdB 3668324 cpdB Shigella sonnei Ss046 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein YP_313113.1 4661629 R 300269 CDS YP_313114.1 74314695 3668325 4663762..4664502 1 NC_007384.1 affects pool of 3'-phosphoadenosine-5'-phosphosulfate in pathway of sulfite synthesis; catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 4664502 cysQ 3668325 cysQ Shigella sonnei Ss046 adenosine-3'(2'),5'-bisphosphate nucleotidase YP_313114.1 4663762 D 300269 CDS YP_313115.1 74314696 3668326 4664714..4665625 1 NC_007384.1 hypothetical protein 4665625 ytfI 3668326 ytfI Shigella sonnei Ss046 hypothetical protein YP_313115.1 4664714 D 300269 CDS YP_313116.1 74314697 3668327 complement(4665715..4666269) 1 NC_007384.1 Code: R; COG: COG3054; hypothetical protein 4666269 ytfJ 3668327 ytfJ Shigella sonnei Ss046 hypothetical protein YP_313116.1 4665715 R 300269 CDS YP_313117.1 74314698 3668328 4666555..4666800 1 NC_007384.1 hypothetical protein 4666800 ytfK 3668328 ytfK Shigella sonnei Ss046 hypothetical protein YP_313117.1 4666555 D 300269 CDS YP_313118.1 74314699 3668329 complement(4666880..4668223) 1 NC_007384.1 Code: R; COG: COG1253; transporter 4668223 ytfL 3668329 ytfL Shigella sonnei Ss046 transporter YP_313118.1 4666880 R 300269 CDS YP_313119.1 74314700 3668330 complement(4668546..4669184) 1 NC_007384.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 4669184 msrA 3668330 msrA Shigella sonnei Ss046 methionine sulfoxide reductase A YP_313119.1 4668546 R 300269 CDS YP_313120.1 74314701 3668331 4669390..4671123 1 NC_007384.1 Code: M; COG: COG0729; hypothetical protein 4671123 ytfM 3668331 ytfM Shigella sonnei Ss046 hypothetical protein YP_313120.1 4669390 D 300269 CDS YP_313121.1 74314702 3668332 4671120..4674899 1 NC_007384.1 Code: S; COG: COG2911; hypothetical protein 4674899 ytfN 3668332 ytfN Shigella sonnei Ss046 hypothetical protein YP_313121.1 4671120 D 300269 CDS YP_313122.1 74314703 3668333 4674902..4675243 1 NC_007384.1 Code: S; COG: COG2105; hypothetical protein 4675243 ytfP 3668333 ytfP Shigella sonnei Ss046 hypothetical protein YP_313122.1 4674902 D 300269 CDS YP_313123.1 74314704 3668295 complement(4675622..4676152) 1 NC_007384.1 catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 4676152 ppa 3668295 ppa Shigella sonnei Ss046 inorganic pyrophosphatase YP_313123.1 4675622 R 300269 CDS YP_313124.1 74314705 3668296 4676462..4677418 1 NC_007384.1 Code: G; COG: COG1879; LACI-type transcriptional regulator 4677418 ytfQ 3668296 ytfQ Shigella sonnei Ss046 LACI-type transcriptional regulator YP_313124.1 4676462 D 300269 CDS YP_313125.1 74314706 3668297 4677558..4679060 1 NC_007384.1 Code: G; COG: COG1129; ABC transporter ATP-binding protein 4679060 ytfR 3668297 ytfR Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_313125.1 4677558 D 300269 CDS YP_313126.1 74314707 3668298 4679071..4680096 1 NC_007384.1 Code: G; COG: COG1172; transport system permease 4680096 ytfT 3668298 ytfT Shigella sonnei Ss046 transport system permease YP_313126.1 4679071 D 300269 CDS YP_313127.1 74314708 3668299 4680107..4681078 1 NC_007384.1 membrane component of a sugar ABC transporter system; ABC transporter permease 4681078 yjfF 3668299 yjfF Shigella sonnei Ss046 ABC transporter permease YP_313127.1 4680107 D 300269 CDS YP_313128.1 74314709 3668300 complement(4681111..4682109) 1 NC_007384.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 4682109 fbp 3668300 fbp Shigella sonnei Ss046 fructose-1,6-bisphosphatase YP_313128.1 4681111 R 300269 CDS YP_313129.1 74314710 3668301 4682285..4683658 1 NC_007384.1 Code: M; COG: COG0773; ligase 4683658 yjfG 3668301 yjfG Shigella sonnei Ss046 ligase YP_313129.1 4682285 D 300269 CDS YP_313130.1 74314711 3668302 complement(4683741..4684292) 1 NC_007384.1 Code: S; COG: COG3028; hypothetical protein 4684292 yjgA 3668302 yjgA Shigella sonnei Ss046 hypothetical protein YP_313130.1 4683741 R 300269 CDS YP_313131.1 74314712 3668303 4684386..4685738 1 NC_007384.1 maturation of antibiotic MccB17, see tld genes; protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 4685738 pmbA 3668303 pmbA Shigella sonnei Ss046 peptidase PmbA YP_313131.1 4684386 D 300269 CDS YP_313132.1 74314713 3668304 4686006..4686308 1 NC_007384.1 Code: C; COG: COG3783; cytochrome b562 4686308 cybC 3668304 cybC Shigella sonnei Ss046 cytochrome b562 YP_313132.1 4686006 D 300269 CDS YP_313133.1 74314714 3668305 complement(4686353..4686817) 1 NC_007384.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein 4686817 nrdG 3668305 nrdG Shigella sonnei Ss046 anaerobic ribonucleotide reductase-activating protein YP_313133.1 4686353 R 300269 CDS YP_313134.1 74314715 3668306 complement(4686975..4689113) 1 NC_007384.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 4689113 nrdD 3668306 nrdD Shigella sonnei Ss046 anaerobic ribonucleoside triphosphate reductase YP_313134.1 4686975 R 300269 CDS YP_313135.1 74314716 3668307 complement(4689507..4691162) 1 NC_007384.1 Code: G; COG: COG0366; trehalose-6-phosphate hydrolase 4691162 treC 3668307 treC Shigella sonnei Ss046 trehalose-6-phosphate hydrolase YP_313135.1 4689507 R 300269 CDS YP_313136.1 74314717 3668308 complement(4691212..4692633) 1 NC_007384.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system trehalose(maltose)-specific transporter subunit IIBC 4692633 treB 3668308 treB Shigella sonnei Ss046 PTS system trehalose(maltose)-specific transporter subunit IIBC YP_313136.1 4691212 R 300269 CDS YP_313137.1 74314718 3668309 complement(4692752..4693699) 1 NC_007384.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor 4693699 treR 3668309 treR Shigella sonnei Ss046 trehalose repressor YP_313137.1 4692752 R 300269 CDS YP_313138.1 74314719 3668310 4694078..4696774 1 NC_007384.1 P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 4696774 mgtA 3668310 mgtA Shigella sonnei Ss046 magnesium-transporting ATPase MgtA YP_313138.1 4694078 D 300269 CDS YP_313139.1 74314720 3668311 complement(4696980..4697405) 1 NC_007384.1 Code: J; COG: COG0251; hypothetical protein 4697405 yjgF 3668311 yjgF Shigella sonnei Ss046 hypothetical protein YP_313139.1 4696980 R 300269 CDS YP_313140.1 74314721 3668312 complement(4697439..4697900) 1 NC_007384.1 involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase 4697900 pyrI 3668312 pyrI Shigella sonnei Ss046 aspartate carbamoyltransferase YP_313140.1 4697439 R 300269 CDS YP_313141.1 74314722 3668313 complement(4697913..4698848) 1 NC_007384.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 4698848 pyrB 3668313 pyrB Shigella sonnei Ss046 aspartate carbamoyltransferase YP_313141.1 4697913 R 300269 CDS YP_313142.1 74314723 3668314 complement(4698852..4698986) 1 NC_007384.1 pyrBI operon leader peptide 4698986 pyrL 3668314 pyrL Shigella sonnei Ss046 pyrBI operon leader peptide YP_313142.1 4698852 R 300269 CDS YP_313143.1 74314724 3668276 complement(4699267..4699662) 1 NC_007384.1 Code: J; COG: COG0251; hypothetical protein 4699662 yjgH 3668276 yjgH Shigella sonnei Ss046 hypothetical protein YP_313143.1 4699267 R 300269 CDS YP_313144.1 74314725 3668277 complement(4699793..4700506) 1 NC_007384.1 Code: IQR; COG: COG1028; oxidoreductase 4700506 yjgI 3668277 yjgI Shigella sonnei Ss046 oxidoreductase YP_313144.1 4699793 R 300269 CDS YP_313145.1 74314726 3668278 4700680..4700844 1 NC_007384.1 hypothetical protein 4700844 3668278 SSON_4430 Shigella sonnei Ss046 hypothetical protein YP_313145.1 4700680 D 300269 CDS YP_313146.1 74314727 3668279 4700916..4701170 1 NC_007384.1 hypothetical protein 4701170 yjgJ 3668279 yjgJ Shigella sonnei Ss046 hypothetical protein YP_313146.1 4700916 D 300269 CDS YP_313147.1 74314728 3668281 4701703..4702206 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4702206 3668281 SSON_4433 Shigella sonnei Ss046 IS1 ORF YP_313147.1 4701703 D 300269 CDS YP_313148.1 74314729 3668283 complement(4703330..4703833) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4703833 3668283 SSON_4435 Shigella sonnei Ss046 IS1 ORF YP_313148.1 4703330 R 300269 CDS YP_313149.1 74314730 3668284 complement(4705168..4706172) 1 NC_007384.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.; ornithine carbamoyltransferase subunit I 4706172 argI 3668284 argI Shigella sonnei Ss046 ornithine carbamoyltransferase subunit I YP_313149.1 4705168 R 300269 CDS YP_313150.1 74314731 3668285 4706334..4706750 1 NC_007384.1 Code: S; COG: COG3076; hypothetical protein 4706750 yjgD 3668285 yjgD Shigella sonnei Ss046 hypothetical protein YP_313150.1 4706334 D 300269 CDS YP_313151.1 74314732 3668286 complement(4706796..4707089) 1 NC_007384.1 Code: KR; COG: COG0454; hypothetical protein 4707089 3668286 SSON_4438 Shigella sonnei Ss046 hypothetical protein YP_313151.1 4706796 R 300269 CDS YP_313152.1 74314733 3668287 complement(4707325..4707702) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4707702 3668287 SSON_4439 Shigella sonnei Ss046 IS1 ORF YP_313152.1 4707325 R 300269 CDS YP_313153.1 74314734 3668288 4707841..4709013 1 NC_007384.1 Code: L; COG: COG4584; IS21 ORF1 4709013 3668288 SSON_4440 Shigella sonnei Ss046 IS21 ORF1 YP_313153.1 4707841 D 300269 CDS YP_313154.1 74314735 3668289 4709013..4709810 1 NC_007384.1 Code: L; COG: COG1484; IS21 ORF2 4709810 3668289 SSON_4441 Shigella sonnei Ss046 IS21 ORF2 YP_313154.1 4709013 D 300269 CDS YP_313155.1 74314736 3668290 4710282..4711478 1 NC_007384.1 Code: S; COG: COG4269; hypothetical protein 4711478 yjgN 3668290 yjgN Shigella sonnei Ss046 hypothetical protein YP_313155.1 4710282 D 300269 CDS YP_313156.1 74314737 3668291 complement(4711534..4714389) 1 NC_007384.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 4714389 valS 3668291 valS Shigella sonnei Ss046 valyl-tRNA synthetase YP_313156.1 4711534 R 300269 CDS YP_313157.1 74314738 3668292 complement(4714389..4714832) 1 NC_007384.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 4714832 holC 3668292 holC Shigella sonnei Ss046 DNA polymerase III subunit chi YP_313157.1 4714389 R 300269 CDS YP_313158.1 74314739 3668293 complement(4714966..4716477) 1 NC_007384.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 4716477 pepA 3668293 pepA Shigella sonnei Ss046 leucyl aminopeptidase YP_313158.1 4714966 R 300269 CDS YP_313159.1 74314740 3668294 4716744..4717844 1 NC_007384.1 Code: R; COG: COG0795; hypothetical protein 4717844 yjgP 3668294 yjgP Shigella sonnei Ss046 hypothetical protein YP_313159.1 4716744 D 300269 CDS YP_313160.1 74314741 3668204 4717841..4718926 1 NC_007384.1 Code: R; COG: COG0795; hypothetical protein 4718926 yjgQ 3668204 yjgQ Shigella sonnei Ss046 hypothetical protein YP_313160.1 4717841 D 300269 CDS YP_313161.1 74314742 3668205 complement(4719045..4720547) 1 NC_007384.1 Code: R; COG: COG0433; hypothetical protein 4720547 yjgR 3668205 yjgR Shigella sonnei Ss046 hypothetical protein YP_313161.1 4719045 R 300269 CDS YP_313162.1 74314743 3668206 complement(4720625..4721599) 1 NC_007384.1 Code: K; COG: COG1609; L-idonate transcriptional regulator 4721599 idnR 3668206 idnR Shigella sonnei Ss046 L-idonate transcriptional regulator YP_313162.1 4720625 R 300269 CDS YP_313163.1 74314744 3668207 complement(4721666..4722985) 1 NC_007384.1 Code: GE; COG: COG2610; L-idonate transporter 4722985 idnT 3668207 idnT Shigella sonnei Ss046 L-idonate transporter YP_313163.1 4721666 R 300269 CDS YP_313164.1 74314745 3668208 complement(4723050..4723814) 1 NC_007384.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase 4723814 idnO 3668208 idnO Shigella sonnei Ss046 gluconate 5-dehydrogenase YP_313164.1 4723050 R 300269 CDS YP_313165.1 74314746 3668209 complement(4723838..4724869) 1 NC_007384.1 NAD-binding; L-idonate 5-dehydrogenase 4724869 idnD 3668209 idnD Shigella sonnei Ss046 L-idonate 5-dehydrogenase YP_313165.1 4723838 R 300269 CDS YP_313166.1 74314747 3668210 4725086..4725649 1 NC_007384.1 thermosensitive glucokinase; Code: G; COG: COG3265; D-gluconate kinase 4725649 idnK 3668210 idnK Shigella sonnei Ss046 D-gluconate kinase YP_313166.1 4725086 D 300269 CDS YP_313167.1 74314748 3668211 complement(4725653..4726714) 1 NC_007384.1 Code: R; COG: COG1064; oxidoreductase 4726714 yjgB 3668211 yjgB Shigella sonnei Ss046 oxidoreductase YP_313167.1 4725653 R 300269 CDS YP_313168.1 74314749 3668213 complement(4727686..4728399) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 4728399 3668213 SSON_4456 Shigella sonnei Ss046 IS600 ORF2 YP_313168.1 4727686 R 300269 CDS YP_313169.1 74314750 3668214 complement(4728540..4728842) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 4728842 3668214 SSON_4457 Shigella sonnei Ss046 IS600 ORF1 YP_313169.1 4728540 R 300269 CDS YP_313170.1 74314751 3668215 4729449..4730288 1 NC_007384.1 Code: L; COG: COG2801; IS911 ORF2 4730288 3668215 SSON_4458 Shigella sonnei Ss046 IS911 ORF2 YP_313170.1 4729449 D 300269 CDS YP_313171.1 74314752 3668216 complement(4730804..4731571) 1 NC_007384.1 Part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate transporter ATP-binding subunit 4731571 fecE 3668216 fecE Shigella sonnei Ss046 iron-dicitrate transporter ATP-binding subunit YP_313171.1 4730804 R 300269 CDS YP_313172.1 74314753 3668217 complement(4731572..4732528) 1 NC_007384.1 Ferric citrate binds FecA and is transported across the outer membrane while transmits a signal across the cytoplasmic membrane protein FecR. FecR transmits a signal across the membrane and activates the cytoplasmic FecI that directs the RNA polymerase to express the fecABCDE operon (which encodes the ferric citrate outer membrane receptor and the ferric citrate ABC transporter), as well as fecIR. FecD is one of two (along with FecC) integral membrane protein components of the iron dicitrate ABC transporter.; iron-dicitrate transporter subunit FecD 4732528 fecD 3668217 fecD Shigella sonnei Ss046 iron-dicitrate transporter subunit FecD YP_313172.1 4731572 R 300269 CDS YP_313173.1 74314754 3668218 complement(4732525..4733523) 1 NC_007384.1 part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate transporter permease subunit 4733523 fecC 3668218 fecC Shigella sonnei Ss046 iron-dicitrate transporter permease subunit YP_313173.1 4732525 R 300269 CDS YP_313174.1 74314755 3668219 complement(4733520..4734428) 1 NC_007384.1 part of the ABC transporter involved in the uptake of citrate-dependent Fe(3+); iron-dicitrate transporter substrate-binding subunit 4734428 fecB 3668219 fecB Shigella sonnei Ss046 iron-dicitrate transporter substrate-binding subunit YP_313174.1 4733520 R 300269 CDS YP_313175.1 74314756 3668220 complement(4734467..4736791) 1 NC_007384.1 citrate-dependent iron transport; Code: P; COG: COG4772; outer membrane receptor 4736791 fecA 3668220 fecA Shigella sonnei Ss046 outer membrane receptor YP_313175.1 4734467 R 300269 CDS YP_313176.1 74314757 3668221 complement(4736878..4737831) 1 NC_007384.1 with FecA forms the FecAR signal transduction system; ferric citrate binds FecA and transmits a signal across the outer membrane to FecR. FecR transmits a signal across the cytoplasmic membrane and activates the sigma 70 protein FecI that directs the RNA polymerase to express the fecABCDE operon; fec operon regulator FecR 4737831 fecR 3668221 fecR Shigella sonnei Ss046 fec operon regulator FecR YP_313176.1 4736878 R 300269 CDS YP_313177.1 74314758 3668222 complement(4737828..4738349) 1 NC_007384.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor regulates the genes for iron dicitrate transport; RNA polymerase sigma factor FecI 4738349 fecI 3668222 fecI Shigella sonnei Ss046 RNA polymerase sigma factor FecI YP_313177.1 4737828 R 300269 CDS YP_313178.1 74314759 3668146 4738641..4738916 1 NC_007384.1 Code: L; COG: COG3677; IS1 ORF1 4738916 insA 3668146 insA Shigella sonnei Ss046 IS1 ORF1 YP_313178.1 4738641 D 300269 CDS YP_313179.1 74314760 3668147 4738835..4739128 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4739128 3668147 SSON_4467 Shigella sonnei Ss046 IS1 ORF YP_313179.1 4738835 D 300269 CDS YP_313180.1 74314761 3668148 4739129..4739338 1 NC_007384.1 IS1 ORF 4739338 3668148 SSON_4468 Shigella sonnei Ss046 IS1 ORF YP_313180.1 4739129 D 300269 CDS YP_313181.1 74314762 3668149 4739626..4740129 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4740129 3668149 SSON_4469 Shigella sonnei Ss046 IS1 ORF YP_313181.1 4739626 D 300269 CDS YP_313182.1 74314763 3668150 4741449..4741952 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4741952 3668150 SSON_4470 Shigella sonnei Ss046 IS1 ORF YP_313182.1 4741449 D 300269 CDS YP_313183.1 74314764 3668151 complement(4742199..4743179) 1 NC_007384.1 Code: L; COG: COG2801; hypothetical protein 4743179 yjhS 3668151 yjhS Shigella sonnei Ss046 hypothetical protein YP_313183.1 4742199 R 300269 CDS YP_313184.1 74314765 3668152 complement(4743244..4744458) 1 NC_007384.1 Code: S; COG: COG3055; N-acetylneuraminic acid mutarotase 4744458 yjhT 3668152 yjhT Shigella sonnei Ss046 N-acetylneuraminic acid mutarotase YP_313184.1 4743244 R 300269 CDS YP_313185.1 74314766 3668153 complement(4744370..4745095) 1 NC_007384.1 hypothetical protein 4745095 yjhA 3668153 yjhA Shigella sonnei Ss046 hypothetical protein YP_313185.1 4744370 R 300269 CDS YP_313186.1 74314767 3668154 4745945..4746976 1 NC_007384.1 Code: L; COG: COG3335; IS630 orf 4746976 3668154 SSON_4474 Shigella sonnei Ss046 IS630 orf YP_313186.1 4745945 D 300269 CDS YP_313187.1 74314768 3668155 4747419..4747922 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4747922 3668155 SSON_4475 Shigella sonnei Ss046 IS1 ORF YP_313187.1 4747419 D 300269 CDS YP_313188.1 74314769 3668157 4749389..4750573 1 NC_007384.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 4750573 uxuA 3668157 uxuA Shigella sonnei Ss046 mannonate dehydratase YP_313188.1 4749389 D 300269 CDS YP_313189.1 74314770 3668158 4750654..4752114 1 NC_007384.1 Code: G; COG: COG0246; D-mannonate oxidoreductase 4752114 uxuB 3668158 uxuB Shigella sonnei Ss046 D-mannonate oxidoreductase YP_313189.1 4750654 D 300269 CDS YP_313190.1 74314771 3668159 4752329..4753102 1 NC_007384.1 regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 4753102 uxuR 3668159 uxuR Shigella sonnei Ss046 DNA-binding transcriptional repressor UxuR YP_313190.1 4752329 D 300269 CDS YP_313191.1 74314772 3668160 complement(4753243..4754073) 1 NC_007384.1 hypothetical protein 4754073 yjiC 3668160 yjiC Shigella sonnei Ss046 hypothetical protein YP_313191.1 4753243 R 300269 CDS YP_313192.1 74314773 3668161 complement(4754214..4754717) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4754717 3668161 SSON_4481 Shigella sonnei Ss046 IS1 ORF YP_313192.1 4754214 R 300269 CDS YP_313193.1 74314774 3668162 4754982..4755755 1 NC_007384.1 hypothetical protein 4755755 3668162 SSON_4482 Shigella sonnei Ss046 hypothetical protein YP_313193.1 4754982 D 300269 CDS YP_313194.1 74314775 3668163 complement(4755734..4756930) 1 NC_007384.1 Code: L; COG: COG3547; ISSfl2 ORF 4756930 3668163 SSON_4483 Shigella sonnei Ss046 ISSfl2 ORF YP_313194.1 4755734 R 300269 CDS YP_313195.1 74314776 3668164 4757338..4758054 1 NC_007384.1 hypothetical protein 4758054 3668164 SSON_4484 Shigella sonnei Ss046 hypothetical protein YP_313195.1 4757338 D 300269 CDS YP_313196.1 74314777 3668126 complement(4758132..4758986) 1 NC_007384.1 Code: R; COG: COG0523; GTP-binding protein YjiA 4758986 yjiA 3668126 yjiA Shigella sonnei Ss046 GTP-binding protein YjiA YP_313196.1 4758132 R 300269 CDS YP_313197.1 74314778 3668127 complement(4759099..4759302) 1 NC_007384.1 Code: S; COG: COG2879; hypothetical protein 4759302 yjiX 3668127 yjiX Shigella sonnei Ss046 hypothetical protein YP_313197.1 4759099 R 300269 CDS YP_313198.1 74314779 3668128 complement(4759352..4761517) 1 NC_007384.1 Code: T; COG: COG1966; carbon starvation protein 4761517 yjiY 3668128 yjiY Shigella sonnei Ss046 carbon starvation protein YP_313198.1 4759352 R 300269 CDS YP_313199.1 74314780 3668129 complement(4761895..4762407) 1 NC_007384.1 Code: R; COG: COG1853; 4-hydroxyphenylacetate 3-monooxygenase coupling protein 4762407 hpaC 3668129 hpaC Shigella sonnei Ss046 4-hydroxyphenylacetate 3-monooxygenase coupling protein YP_313199.1 4761895 R 300269 CDS YP_313200.1 74314781 3668130 complement(4762425..4763987) 1 NC_007384.1 Code: Q; COG: COG2368; 4-hydroxyphenylacetate 3-monooxygenase 4763987 hpaB 3668130 hpaB Shigella sonnei Ss046 4-hydroxyphenylacetate 3-monooxygenase YP_313200.1 4762425 R 300269 CDS YP_313201.1 74314782 3668131 complement(4764928..4765641) 1 NC_007384.1 Code: L; COG: COG2801; IS600 ORF2 4765641 3668131 SSON_4490 Shigella sonnei Ss046 IS600 ORF2 YP_313201.1 4764928 R 300269 CDS YP_313202.1 74314783 3668132 complement(4765782..4766084) 1 NC_007384.1 Code: L; COG: COG2963; IS600 ORF1 4766084 3668132 SSON_4491 Shigella sonnei Ss046 IS600 ORF1 YP_313202.1 4765782 R 300269 CDS YP_313203.1 74314784 3668134 complement(4766405..4767781) 1 NC_007384.1 Code: GEPR; COG: COG0477; 4-hydroxyphenylacetate permease 4767781 hpaX 3668134 hpaX Shigella sonnei Ss046 4-hydroxyphenylacetate permease YP_313203.1 4766405 R 300269 CDS YP_313204.1 74314785 3668135 complement(4767956..4768744) 1 NC_007384.1 Code: G; COG: COG3836; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase 4768744 hpaI 3668135 hpaI Shigella sonnei Ss046 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase YP_313204.1 4767956 R 300269 CDS YP_313205.1 74314786 3668136 complement(4768755..4769558) 1 NC_007384.1 Code: Q; COG: COG3971; 2-oxo-hepta-3-ene-1,7-dioic acid hydratase 4769558 hpaH 3668136 hpaH Shigella sonnei Ss046 2-oxo-hepta-3-ene-1,7-dioic acid hydratase YP_313205.1 4768755 R 300269 CDS YP_313206.1 74314787 3668137 complement(4769669..4770049) 1 NC_007384.1 Code: E; COG: COG3232; 5-carboxymethyl-2-hydroxymuconate delta-isomerase 4770049 hpaF 3668137 hpaF Shigella sonnei Ss046 5-carboxymethyl-2-hydroxymuconate delta-isomerase YP_313206.1 4769669 R 300269 CDS YP_313207.1 74314788 3668138 complement(4770059..4770910) 1 NC_007384.1 Code: S; COG: COG3384; homoprotocatechuate dyoxygenase 4770910 hpaD 3668138 hpaD Shigella sonnei Ss046 homoprotocatechuate dyoxygenase YP_313207.1 4770059 R 300269 CDS YP_313208.1 74314789 3668139 complement(4770912..4772378) 1 NC_007384.1 Code: C; COG: COG1012; 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase 4772378 hpaE 3668139 hpaE Shigella sonnei Ss046 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase YP_313208.1 4770912 R 300269 CDS YP_313209.1 74314790 3668140 complement(4772375..4773664) 1 NC_007384.1 Code: Q; COG: COG0179; 5-oxo-1,2,5-tricarboxilic-3-penten acid decarboxylase/isomerase 4773664 hpaG 3668140 hpaG Shigella sonnei Ss046 5-oxo-1,2,5-tricarboxilic-3-penten acid decarboxylase/isomerase YP_313209.1 4772375 R 300269 CDS YP_313210.1 74314791 3668141 4773936..4774382 1 NC_007384.1 Code: K; COG: COG1846; homoprotocatechuate degradative operon repressor 4774382 hpcR 3668141 hpcR Shigella sonnei Ss046 homoprotocatechuate degradative operon repressor YP_313210.1 4773936 D 300269 CDS YP_313211.1 74314792 3668144 complement(4777771..4778577) 1 NC_007384.1 Code: K; COG: COG1802; hypothetical protein 4778577 yjjM 3668144 yjjM Shigella sonnei Ss046 hypothetical protein YP_313211.1 4777771 R 300269 CDS YP_313212.1 74314793 3668145 4778809..4779846 1 NC_007384.1 Code: ER; COG: COG1063; oxidoreductase 4779846 yjjN 3668145 yjjN Shigella sonnei Ss046 oxidoreductase YP_313212.1 4778809 D 300269 CDS YP_313213.2 161986380 3668071 complement(4779985..4782276) 1 NC_007384.1 catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I 4782276 mdoB 3668071 mdoB Shigella sonnei Ss046 phosphoglycerol transferase I YP_313213.2 4779985 R 300269 CDS YP_313214.1 74314795 3668072 complement(4782530..4783027) 1 NC_007384.1 hypothetical protein 4783027 yjjA 3668072 yjjA Shigella sonnei Ss046 hypothetical protein YP_313214.1 4782530 R 300269 CDS YP_313215.1 74314796 3668073 complement(4783073..4783810) 1 NC_007384.1 acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC 4783810 dnaC 3668073 dnaC Shigella sonnei Ss046 DNA replication protein DnaC YP_313215.1 4783073 R 300269 CDS YP_313216.1 74314797 3668074 complement(4783813..4784352) 1 NC_007384.1 DNA biosynthesis; This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI 4784352 dnaT 3668074 dnaT Shigella sonnei Ss046 primosomal protein DnaI YP_313216.1 4783813 R 300269 CDS YP_313217.2 228861775 3668075 complement(4784460..4784933) 1 NC_007384.1 Code: S; COG: COG3610; hypothetical protein 4784933 yjjB 3668075 yjjB Shigella sonnei Ss046 hypothetical protein YP_313217.2 4784460 R 300269 CDS YP_313218.1 74314799 3668076 complement(4784924..4785757) 1 NC_007384.1 Code: S; COG: COG2966; structural protein 4785757 yjjP 3668076 yjjP Shigella sonnei Ss046 structural protein YP_313218.1 4784924 R 300269 CDS YP_313219.1 74314800 3668077 4786637..4787140 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4787140 3668077 SSON_4511 Shigella sonnei Ss046 IS1 ORF YP_313219.1 4786637 D 300269 CDS YP_313220.1 74314801 3668078 complement(4787533..4788162) 1 NC_007384.1 Code: L; COG: COG1662; IS1 ORF 4788162 3668078 SSON_4512 Shigella sonnei Ss046 IS1 ORF YP_313220.1 4787533 R 300269 CDS YP_313221.2 161986379 3668079 4788566..4789189 1 NC_007384.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; DNA-binding transcriptional activator BglJ 4789189 bglJ 3668079 bglJ Shigella sonnei Ss046 DNA-binding transcriptional activator BglJ YP_313221.2 4788566 D 300269 CDS YP_313222.1 74314803 3668080 complement(4789227..4790015) 1 NC_007384.1 Code: R; COG: COG4114; ferric hydroximate transport ferric iron reductase 4790015 fhuF 3668080 fhuF Shigella sonnei Ss046 ferric hydroximate transport ferric iron reductase YP_313222.1 4789227 R 300269 CDS YP_313223.1 74314804 3668081 4790045..4790392 1 NC_007384.1 inner membrane protein 4790392 3668081 SSON_4515 Shigella sonnei Ss046 inner membrane protein YP_313223.1 4790045 D 300269 CDS YP_313224.1 74314805 3668054 complement(4791257..4792288) 1 NC_007384.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase 4792288 rsmC 3668054 rsmC Shigella sonnei Ss046 16S ribosomal RNA m2G1207 methyltransferase YP_313224.1 4791257 R 300269 CDS YP_313225.1 74314806 3668055 4792391..4792804 1 NC_007384.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 4792804 holD 3668055 holD Shigella sonnei Ss046 DNA polymerase III subunit psi YP_313225.1 4792391 D 300269 CDS YP_313226.1 74314807 3668056 4792773..4793219 1 NC_007384.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 4793219 rimI 3668056 rimI Shigella sonnei Ss046 ribosomal-protein-alanine N-acetyltransferase YP_313226.1 4792773 D 300269 CDS YP_313227.1 74314808 3668057 4793234..4793911 1 NC_007384.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 4793911 yjjG 3668057 yjjG Shigella sonnei Ss046 nucleotidase YP_313227.1 4793234 D 300269 CDS YP_313228.1 74314809 3668058 4794002..4795591 1 NC_007384.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 4795591 prfC 3668058 prfC Shigella sonnei Ss046 peptide chain release factor 3 YP_313228.1 4794002 D 300269 CDS YP_313229.1 74314810 3668059 4795984..4796589 1 NC_007384.1 Code: R; COG: COG2823; hypothetical protein 4796589 osmY 3668059 osmY Shigella sonnei Ss046 hypothetical protein YP_313229.1 4795984 D 300269 CDS YP_313230.1 74314811 3668060 4796716..4796877 1 NC_007384.1 Code: S; COG: COG5487; hypothetical protein 4796877 3668060 SSON_4527 Shigella sonnei Ss046 hypothetical protein YP_313230.1 4796716 D 300269 CDS YP_313231.1 74314812 3668061 4796999..4798072 1 NC_007384.1 Code: R; COG: COG4667; hypothetical protein 4798072 yjjU 3668061 yjjU Shigella sonnei Ss046 hypothetical protein YP_313231.1 4796999 D 300269 CDS YP_313232.1 74314813 3668062 4798069..4798851 1 NC_007384.1 Code: L; COG: COG0084; deoxyribonuclease YjjV 4798851 yjjV 3668062 yjjV Shigella sonnei Ss046 deoxyribonuclease YjjV YP_313232.1 4798069 D 300269 CDS YP_313233.1 74314814 3668063 complement(4799367..4800230) 1 NC_007384.1 Code: O; COG: COG1180; activating enzyme 4800230 yjjW 3668063 yjjW Shigella sonnei Ss046 activating enzyme YP_313233.1 4799367 R 300269 CDS YP_313234.1 74314815 3668064 complement(4800202..4801752) 1 NC_007384.1 hypothetical protein 4801752 yjjI 3668064 yjjI Shigella sonnei Ss046 hypothetical protein YP_313234.1 4800202 R 300269 CDS YP_313235.1 74314816 3668065 4802010..4802789 1 NC_007384.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 4802789 deoC 3668065 deoC Shigella sonnei Ss046 deoxyribose-phosphate aldolase YP_313235.1 4802010 D 300269 CDS YP_313236.1 74314817 3668066 4802916..4804238 1 NC_007384.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 4804238 deoA 3668066 deoA Shigella sonnei Ss046 thymidine phosphorylase YP_313236.1 4802916 D 300269 CDS YP_313237.1 74314818 3668067 4804290..4805513 1 NC_007384.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 4805513 deoB 3668067 deoB Shigella sonnei Ss046 phosphopentomutase YP_313237.1 4804290 D 300269 CDS YP_313238.1 74314819 3668068 4805593..4806312 1 NC_007384.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 4806312 deoD 3668068 deoD Shigella sonnei Ss046 purine nucleoside phosphorylase YP_313238.1 4805593 D 300269 CDS YP_313239.1 74314820 3668069 complement(4806768..4807784) 1 NC_007384.1 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; lipoate-protein ligase A 4807784 lplA 3668069 lplA Shigella sonnei Ss046 lipoate-protein ligase A YP_313239.1 4806768 R 300269 CDS YP_313240.1 74314821 3668070 complement(4807812..4808456) 1 NC_007384.1 Code: R; COG: COG3726; hypothetical protein 4808456 smp 3668070 smp Shigella sonnei Ss046 hypothetical protein YP_313240.1 4807812 R 300269 CDS YP_313241.1 74314822 3667846 4808562..4809530 1 NC_007384.1 catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 4809530 serB 3667846 serB Shigella sonnei Ss046 phosphoserine phosphatase YP_313241.1 4808562 D 300269 CDS YP_313242.1 74314823 3667847 4809579..4810961 1 NC_007384.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 4810961 sms 3667847 sms Shigella sonnei Ss046 DNA repair protein RadA YP_313242.1 4809579 D 300269 CDS YP_313243.2 161986378 3667848 4810982..4812214 1 NC_007384.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 4812214 nadR 3667848 nadR Shigella sonnei Ss046 nicotinamide-nucleotide adenylyltransferase YP_313243.2 4810982 D 300269 CDS YP_313244.1 74314825 3667849 complement(4812521..4814188) 1 NC_007384.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 4814188 yjjK 3667849 yjjK Shigella sonnei Ss046 ABC transporter ATP-binding protein YP_313244.1 4812521 R 300269 CDS YP_313245.2 161986377 3667850 4814399..4816336 1 NC_007384.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 4816336 slt 3667850 slt Shigella sonnei Ss046 lytic murein transglycosylase YP_313245.2 4814399 D 300269 CDS YP_313246.1 74314827 3667851 4816426..4816752 1 NC_007384.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 4816752 trpR 3667851 trpR Shigella sonnei Ss046 Trp operon repressor YP_313246.1 4816426 D 300269 CDS YP_313247.2 161986376 3667852 complement(4816837..4817358) 1 NC_007384.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase 4817358 yjjX 3667852 yjjX Shigella sonnei Ss046 NTPase YP_313247.2 4816837 R 300269 CDS YP_313248.1 74314829 3667853 4817410..4818057 1 NC_007384.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 4818057 gpmB 3667853 gpmB Shigella sonnei Ss046 phosphoglycerate mutase YP_313248.1 4817410 D 300269 CDS YP_313249.1 74314830 3667854 complement(4818054..4818923) 1 NC_007384.1 Code: K; COG: COG2207; right origin-binding protein 4818923 rob 3667854 rob Shigella sonnei Ss046 right origin-binding protein YP_313249.1 4818054 R 300269 CDS YP_313250.1 74314831 3667855 4819134..4819607 1 NC_007384.1 Code: S; COG: COG3045; hypothetical protein 4819607 creA 3667855 creA Shigella sonnei Ss046 hypothetical protein YP_313250.1 4819134 D 300269 CDS YP_313251.1 74314832 3667856 4819620..4820309 1 NC_007384.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 4820309 creB 3667856 creB Shigella sonnei Ss046 DNA-binding response regulator CreB YP_313251.1 4819620 D 300269 CDS YP_313252.1 74314833 3667857 4820309..4821733 1 NC_007384.1 alternative sensor for pho regulon; part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 4821733 creC 3667857 creC Shigella sonnei Ss046 sensory histidine kinase CreC YP_313252.1 4820309 D 300269 CDS YP_313253.1 74314834 3667858 4821791..4823143 1 NC_007384.1 Code: V; COG: COG4452; hypothetical protein 4823143 creD 3667858 creD Shigella sonnei Ss046 hypothetical protein YP_313253.1 4821791 D 300269 CDS YP_313254.1 74314835 3667859 complement(4823203..4823919) 1 NC_007384.1 Code: TK; COG: COG0745; two-component response regulator 4823919 arcA 3667859 arcA Shigella sonnei Ss046 two-component response regulator YP_313254.1 4823203 R 300269 CDS YP_313255.1 74314836 3667860 4824015..4824155 1 NC_007384.1 hypothetical protein 4824155 yjjY 3667860 yjjY Shigella sonnei Ss046 hypothetical protein YP_313255.1 4824015 D 300269 CDS YP_313256.1 74314837 3667861 4824555..4825241 1 NC_007384.1 member of the SPOUT superfamily of methyltransferases; RNA methyltransferase 4825241 lasT 3667861 lasT Shigella sonnei Ss046 RNA methyltransferase YP_313256.1 4824555 D 300269 CDS YP_313257.1 74314840 3670804 complement(275..493) 1 NC_007385.1 IS2 ORF2 493 3670804 SSON_P002 Shigella sonnei Ss046 IS2 ORF2 YP_313257.1 275 R 300269 CDS YP_313258.1 74314839 3670803 485..949 1 NC_007385.1 putative resolvase, fragment 949 3670803 SSON_P001 Shigella sonnei Ss046 putative resolvase, fragment YP_313258.1 485 D 300269 CDS YP_313259.1 74314841 3670805 1176..2042 1 NC_007385.1 protein secreted by the Mxi-Spa secretion machinery; OspB 2042 ospB 3670805 ospB Shigella sonnei Ss046 OspB YP_313259.1 1176 D 300269 CDS YP_313260.1 74314842 3670806 2371..3111 1 NC_007385.1 periplasmic phosphatase, apyrase, ATP diphosphohydrolase; PhoN2 (Apy) 3111 phoN2/apy 3670806 phoN2/apy Shigella sonnei Ss046 PhoN2 (Apy) YP_313260.1 2371 D 300269 CDS YP_313261.1 74314843 3670807 3363..3581 1 NC_007385.1 hypothetical protein 3581 3670807 SSON_P005 Shigella sonnei Ss046 hypothetical protein YP_313261.1 3363 D 300269 CDS YP_313262.1 74314844 3670808 3729..4760 1 NC_007385.1 IS630 orf 4760 3670808 SSON_P006 Shigella sonnei Ss046 IS630 orf YP_313262.1 3729 D 300269 CDS YP_313263.1 74314845 3670810 complement(5491..7200) 1 NC_007385.1 probably secreted by the Mxi-Spa secretion machinery; OspD2 7200 ospD2 3670810 ospD2 Shigella sonnei Ss046 OspD2 YP_313263.1 5491 R 300269 CDS YP_313264.1 74314846 3670811 complement(7632..8351) 1 NC_007385.1 secreted by the Mxi-Spa secretion machinery; OspF 8351 ospF 3670811 ospF Shigella sonnei Ss046 OspF YP_313264.1 7632 R 300269 CDS YP_313265.1 74314847 3670812 complement(8476..9060) 1 NC_007385.1 hypothetical protein 9060 3670812 SSON_P010 Shigella sonnei Ss046 hypothetical protein YP_313265.1 8476 R 300269 CDS YP_313266.1 74314848 3670813 complement(9390..9968) 1 NC_007385.1 hypothetical protein 9968 3670813 SSON_P011 Shigella sonnei Ss046 hypothetical protein YP_313266.1 9390 R 300269 CDS YP_313267.1 74314849 3670814 10630..11661 1 NC_007385.1 IS630 orf 11661 3670814 SSON_P012 Shigella sonnei Ss046 IS630 orf YP_313267.1 10630 D 300269 CDS YP_313268.1 74314850 3670815 complement(11667..11846) 1 NC_007385.1 IS21 ORF2 11846 3670815 SSON_P013 Shigella sonnei Ss046 IS21 ORF2 YP_313268.1 11667 R 300269 CDS YP_313269.1 74314851 3670816 complement(12094..12450) 1 NC_007385.1 IS91 orf 12450 3670816 SSON_P014 Shigella sonnei Ss046 IS91 orf YP_313269.1 12094 R 300269 CDS YP_313270.1 74314852 3670986 complement(12450..12635) 1 NC_007385.1 putative IS91 ORF2 12635 3670986 SSON_P015 Shigella sonnei Ss046 putative IS91 ORF2 YP_313270.1 12450 R 300269 CDS YP_313271.1 74314853 3670987 12798..13082 1 NC_007385.1 putative transposase 13082 3670987 SSON_P016 Shigella sonnei Ss046 putative transposase YP_313271.1 12798 D 300269 CDS YP_313272.1 74314854 3670988 complement(13093..13665) 1 NC_007385.1 IS4 orf 13665 3670988 SSON_P017 Shigella sonnei Ss046 IS4 orf YP_313272.1 13093 R 300269 CDS YP_313273.1 74314855 3670989 13793..14140 1 NC_007385.1 ISSfl4 ORF2 14140 3670989 SSON_P018 Shigella sonnei Ss046 ISSfl4 ORF2 YP_313273.1 13793 D 300269 CDS YP_313274.1 74314856 3670990 14160..15392 1 NC_007385.1 putative IS orf, fragment 15392 3670990 SSON_P019 Shigella sonnei Ss046 putative IS orf, fragment YP_313274.1 14160 D 300269 CDS YP_313275.1 74314857 3670991 16042..16200 1 NC_007385.1 putative transposase, fragment 16200 3670991 SSON_P020 Shigella sonnei Ss046 putative transposase, fragment YP_313275.1 16042 D 300269 CDS YP_313276.1 74314858 3670992 16197..16367 1 NC_007385.1 putative transposase, fragment 16367 3670992 SSON_P021 Shigella sonnei Ss046 putative transposase, fragment YP_313276.1 16197 D 300269 CDS YP_313277.1 74314859 3670993 16954..17631 1 NC_007385.1 secreted by the Mxi-Spa secretion machinery; OspD1 17631 ospD1 3670993 ospD1 Shigella sonnei Ss046 OspD1 YP_313277.1 16954 D 300269 CDS YP_313278.1 74314860 3670994 complement(18113..18337) 1 NC_007385.1 hypothetical protein 18337 3670994 SSON_P023 Shigella sonnei Ss046 hypothetical protein YP_313278.1 18113 R 300269 CDS YP_313279.1 74314861 3670995 18740..19306 1 NC_007385.1 probably secreted by the Mxi-Spa secretion machinery; IpgB2 19306 ipgB2 3670995 ipgB2 Shigella sonnei Ss046 IpgB2 YP_313279.1 18740 D 300269 CDS YP_313280.1 74314862 3670996 19878..20177 1 NC_007385.1 IS3 ORF1 20177 3670996 SSON_P025 Shigella sonnei Ss046 IS3 ORF1 YP_313280.1 19878 D 300269 CDS YP_313281.1 74314863 3670997 20174..21043 1 NC_007385.1 IS3 ORF2 21043 3670997 SSON_P026 Shigella sonnei Ss046 IS3 ORF2 YP_313281.1 20174 D 300269 CDS YP_313282.1 74314864 3670998 21831..22835 1 NC_007385.1 IS100 ORF1 22835 3670998 SSON_P027 Shigella sonnei Ss046 IS100 ORF1 YP_313282.1 21831 D 300269 CDS YP_313283.1 74314865 3670999 23027..24223 1 NC_007385.1 ISSfl2 ORF 24223 3670999 SSON_P028 Shigella sonnei Ss046 ISSfl2 ORF YP_313283.1 23027 D 300269 CDS YP_313284.1 74314866 3671000 24497..25624 1 NC_007385.1 putative transposase 25624 3671000 SSON_P029 Shigella sonnei Ss046 putative transposase YP_313284.1 24497 D 300269 CDS YP_313285.1 74314867 3671001 26092..26307 1 NC_007385.1 iso-IS1 ORF2 26307 3671001 SSON_P030 Shigella sonnei Ss046 iso-IS1 ORF2 YP_313285.1 26092 D 300269 CDS YP_313286.1 74314868 3671002 26629..27828 1 NC_007385.1 plasmid segregation protein 27828 parA 3671002 parA Shigella sonnei Ss046 plasmid segregation protein YP_313286.1 26629 D 300269 CDS YP_313287.1 74314869 3671003 27828..28808 1 NC_007385.1 plasmid segregation protein 28808 parB 3671003 parB Shigella sonnei Ss046 plasmid segregation protein YP_313287.1 27828 D 300269 CDS YP_313288.1 74314870 3671004 29064..29549 1 NC_007385.1 putative transposase, fragment 29549 3671004 SSON_P033 Shigella sonnei Ss046 putative transposase, fragment YP_313288.1 29064 D 300269 CDS YP_313289.1 74314871 3671005 complement(29838..30437) 1 NC_007385.1 hypothetical protein 30437 3671005 SSON_P034 Shigella sonnei Ss046 hypothetical protein YP_313289.1 29838 R 300269 CDS YP_313290.1 74314872 3671006 complement(30380..30964) 1 NC_007385.1 hypothetical protein 30964 3671006 SSON_P035 Shigella sonnei Ss046 hypothetical protein YP_313290.1 30380 R 300269 CDS YP_313291.1 74314873 3671007 31617..32765 1 NC_007385.1 IS21 ORF1 32765 3671007 SSON_P036 Shigella sonnei Ss046 IS21 ORF1 YP_313291.1 31617 D 300269 CDS YP_313292.1 74314874 3671008 32765..33562 1 NC_007385.1 IS21 ORF2 33562 3671008 SSON_P037 Shigella sonnei Ss046 IS21 ORF2 YP_313292.1 32765 D 300269 CDS YP_313293.1 74314875 3671009 complement(33890..34777) 1 NC_007385.1 IS629 ORF2 34777 3671009 SSON_P038 Shigella sonnei Ss046 IS629 ORF2 YP_313293.1 33890 R 300269 CDS YP_313294.1 74314876 3671010 complement(34777..35052) 1 NC_007385.1 IS629 ORF1 35052 3671010 SSON_P039 Shigella sonnei Ss046 IS629 ORF1 YP_313294.1 34777 R 300269 CDS YP_313295.1 74314877 3671011 35770..36969 1 NC_007385.1 IS1294 orf 36969 3671011 SSON_P040 Shigella sonnei Ss046 IS1294 orf YP_313295.1 35770 D 300269 CDS YP_313296.1 74314878 3671012 complement(37224..38012) 1 NC_007385.1 member of the AraC family of transcriptional activators; required for transcription of virB and icsA; VirF 38012 virF 3671012 virF Shigella sonnei Ss046 VirF YP_313296.1 37224 R 300269 CDS YP_313297.1 74314879 3671013 38511..39638 1 NC_007385.1 putative transposase 39638 3671013 SSON_P042 Shigella sonnei Ss046 putative transposase YP_313297.1 38511 D 300269 CDS YP_313298.1 74314880 3671014 40072..40359 1 NC_007385.1 IS2 ORF2 40359 3671014 SSON_P043 Shigella sonnei Ss046 IS2 ORF2 YP_313298.1 40072 D 300269 CDS YP_313299.1 74314881 3671015 40541..40807 1 NC_007385.1 secreted by the Mxi-Spa secretion machinery; OspE2 40807 ospE2 3671015 ospE2 Shigella sonnei Ss046 OspE2 YP_313299.1 40541 D 300269 CDS YP_313300.1 74314882 3671016 complement(41178..41594) 1 NC_007385.1 ISSfl2 ORF 41594 3671016 SSON_P045 Shigella sonnei Ss046 ISSfl2 ORF YP_313300.1 41178 R 300269 CDS YP_313301.1 74314883 3671017 complement(41773..42318) 1 NC_007385.1 ISSfl2 ORF 42318 3671017 SSON_P046 Shigella sonnei Ss046 ISSfl2 ORF YP_313301.1 41773 R 300269 CDS YP_313302.1 74314884 3671018 42373..42645 1 NC_007385.1 hypothetical protein 42645 3671018 SSON_P047 Shigella sonnei Ss046 hypothetical protein YP_313302.1 42373 D 300269 CDS YP_313303.1 74314885 3671019 42626..43834 1 NC_007385.1 IS1294 orf 43834 3671019 SSON_P048 Shigella sonnei Ss046 IS1294 orf YP_313303.1 42626 D 300269 CDS YP_313304.1 74314886 3671020 44739..46151 1 NC_007385.1 secreted by the Mxi-Spa secretion machinery; OspC1 46151 ospC1 3671020 ospC1 Shigella sonnei Ss046 OspC1 YP_313304.1 44739 D 300269 CDS YP_313305.1 74314887 3671021 46480..48177 1 NC_007385.1 SenA; probably secreted by the Mxi-Spa secretion machinery; OspD3 48177 ospD3 3671021 ospD3 Shigella sonnei Ss046 OspD3 YP_313305.1 46480 D 300269 CDS YP_313306.1 74314888 3671022 complement(48324..48854) 1 NC_007385.1 IS600 ORF2 48854 3671022 SSON_P051 Shigella sonnei Ss046 IS600 ORF2 YP_313306.1 48324 R 300269 CDS YP_313307.1 74314889 3671023 complement(48995..49297) 1 NC_007385.1 IS600 ORF1 49297 3671023 SSON_P052 Shigella sonnei Ss046 IS600 ORF1 YP_313307.1 48995 R 300269 CDS YP_313308.1 74314890 3671024 49336..49803 1 NC_007385.1 hypothetical protein 49803 3671024 SSON_P053 Shigella sonnei Ss046 hypothetical protein YP_313308.1 49336 D 300269 CDS YP_313309.1 74314891 3671025 50243..50713 1 NC_007385.1 ISSfl1 ORF1 50713 3671025 SSON_P054 Shigella sonnei Ss046 ISSfl1 ORF1 YP_313309.1 50243 D 300269 CDS YP_313310.1 74314892 3671026 50719..51108 1 NC_007385.1 ISSfl1 ORF2 51108 3671026 SSON_P055 Shigella sonnei Ss046 ISSfl1 ORF2 YP_313310.1 50719 D 300269 CDS YP_313311.1 74314893 3671027 51223..52254 1 NC_007385.1 IS630 orf 52254 3671027 SSON_P056 Shigella sonnei Ss046 IS630 orf YP_313311.1 51223 D 300269 CDS YP_313312.1 74314894 3671028 complement(52274..52525) 1 NC_007385.1 hypothetical protein 52525 3671028 SSON_P057 Shigella sonnei Ss046 hypothetical protein YP_313312.1 52274 R 300269 CDS YP_313313.1 74314895 3671029 53671..55368 1 NC_007385.1 probably secreted by the Mxi-Spa machinery; invasion plasmid antigen 55368 ipaH7.8 3671029 ipaH7.8 Shigella sonnei Ss046 invasion plasmid antigen YP_313313.1 53671 D 300269 CDS YP_313314.1 74314896 3671030 55796..57520 1 NC_007385.1 probably secreted by the Mxi-Spa machinery; invasion plasmid antigen 57520 ipaH4.5 3671030 ipaH4.5 Shigella sonnei Ss046 invasion plasmid antigen YP_313314.1 55796 D 300269 CDS YP_313315.1 74314897 3671031 57572..57898 1 NC_007385.1 IS629 ORF1 57898 3671031 SSON_P060 Shigella sonnei Ss046 IS629 ORF1 YP_313315.1 57572 D 300269 CDS YP_313316.1 74314898 3671032 57898..58785 1 NC_007385.1 IS629 ORF2 58785 3671032 SSON_P061 Shigella sonnei Ss046 IS629 ORF2 YP_313316.1 57898 D 300269 CDS YP_313317.1 74314899 3671033 59338..60243 1 NC_007385.1 IS1294 orf 60243 3671033 SSON_P062 Shigella sonnei Ss046 IS1294 orf YP_313317.1 59338 D 300269 CDS YP_313318.1 74314900 3671034 60545..60994 1 NC_007385.1 ISSfl1 ORF1 60994 3671034 SSON_P063 Shigella sonnei Ss046 ISSfl1 ORF1 YP_313318.1 60545 D 300269 CDS YP_313319.1 74314901 3671035 61000..61389 1 NC_007385.1 ISSfl1 ORF2 61389 3671035 SSON_P064 Shigella sonnei Ss046 ISSfl1 ORF2 YP_313319.1 61000 D 300269 CDS YP_313320.1 74314902 3671036 complement(61538..62992) 1 NC_007385.1 probably secreted by the Mxi-Spa secretion machinery; OspC2 62992 ospC2 3671036 ospC2 Shigella sonnei Ss046 OspC2 YP_313320.1 61538 R 300269 CDS YP_313321.1 74314903 3671037 63417..63713 1 NC_007385.1 ISSfl1 ORF1 63713 3671037 SSON_P066 Shigella sonnei Ss046 ISSfl1 ORF1 YP_313321.1 63417 D 300269 CDS YP_313322.1 74314904 3671038 63936..64439 1 NC_007385.1 IS1 ORF2 64439 insB 3671038 insB Shigella sonnei Ss046 IS1 ORF2 YP_313322.1 63936 D 300269 CDS YP_313323.1 74314905 3671039 64523..64885 1 NC_007385.1 ISSfl1 ORF2 64885 3671039 SSON_P068 Shigella sonnei Ss046 ISSfl1 ORF2 YP_313323.1 64523 D 300269 CDS YP_313324.1 74314906 3671040 complement(65173..66087) 1 NC_007385.1 IS1294 orf 66087 3671040 SSON_P069 Shigella sonnei Ss046 IS1294 orf YP_313324.1 65173 R 300269 CDS YP_313325.1 74314907 3671041 complement(66068..66340) 1 NC_007385.1 hypothetical protein 66340 3671041 SSON_P070 Shigella sonnei Ss046 hypothetical protein YP_313325.1 66068 R 300269 CDS YP_313326.1 74314908 3671042 complement(66360..66947) 1 NC_007385.1 ISSfl4 ORF1 66947 3671042 SSON_P071 Shigella sonnei Ss046 ISSfl4 ORF1 YP_313326.1 66360 R 300269 CDS YP_313327.1 74314909 3671043 67363..68817 1 NC_007385.1 probably secreted by the Mxi-Spa secretion machinery; OspC3 68817 ospC3 3671043 ospC3 Shigella sonnei Ss046 OspC3 YP_313327.1 67363 D 300269 CDS YP_313328.1 74314910 3670817 69155..69457 1 NC_007385.1 IS600 ORF1 69457 3670817 SSON_P073 Shigella sonnei Ss046 IS600 ORF1 YP_313328.1 69155 D 300269 CDS YP_313329.1 74314911 3670818 69598..70311 1 NC_007385.1 IS600 ORF2 70311 3670818 SSON_P074 Shigella sonnei Ss046 IS600 ORF2 YP_313329.1 69598 D 300269 CDS YP_313330.1 74314912 3670819 70436..70678 1 NC_007385.1 putative IS orf 70678 3670819 SSON_P075 Shigella sonnei Ss046 putative IS orf YP_313330.1 70436 D 300269 CDS YP_313331.1 74314913 3670820 70733..71155 1 NC_007385.1 IS1353 putative transposase-like protein 71155 3670820 SSON_P076 Shigella sonnei Ss046 IS1353 putative transposase-like protein YP_313331.1 70733 D 300269 CDS YP_313332.1 74314914 3670821 71276..71611 1 NC_007385.1 IS21 ORF1 71611 3670821 SSON_P077 Shigella sonnei Ss046 IS21 ORF1 YP_313332.1 71276 D 300269 CDS YP_313333.1 74314915 3670822 71581..71874 1 NC_007385.1 hypothetical protein 71874 3670822 SSON_P078 Shigella sonnei Ss046 hypothetical protein YP_313333.1 71581 D 300269 CDS YP_313334.2 161986603 3670823 complement(72065..72970) 1 NC_007385.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 72970 3670823 SSON_P079 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_313334.2 72065 R 300269 CDS YP_313335.1 74314917 3670824 complement(72928..73293) 1 NC_007385.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 73293 3670824 SSON_P080 Shigella sonnei Ss046 insertion sequence 2 OrfA protein YP_313335.1 72928 R 300269 CDS YP_313336.1 74314918 3670825 complement(73542..74738) 1 NC_007385.1 ISSfl2 ORF 74738 3670825 SSON_P081 Shigella sonnei Ss046 ISSfl2 ORF YP_313336.1 73542 R 300269 CDS YP_313337.1 74314919 3670826 complement(74930..75934) 1 NC_007385.1 IS100 ORF1 75934 3670826 SSON_P082 Shigella sonnei Ss046 IS100 ORF1 YP_313337.1 74930 R 300269 CDS YP_313338.1 74314920 3670827 76173..76373 1 NC_007385.1 hypothetical protein 76373 3670827 SSON_P083 Shigella sonnei Ss046 hypothetical protein YP_313338.1 76173 D 300269 CDS YP_313339.1 74314921 3670828 77287..78066 1 NC_007385.1 invasion plasmid antigen; IpaJ 78066 ipaJ 3670828 ipaJ Shigella sonnei Ss046 IpaJ YP_313339.1 77287 D 300269 CDS YP_313340.1 74314922 3670829 complement(79012..79941) 1 NC_007385.1 transcriptional activator required for tanscription of the ipa, mxi, and spa operons; VirB 79941 virB 3670829 virB Shigella sonnei Ss046 VirB YP_313340.1 79012 R 300269 CDS YP_313341.1 74314923 3670830 complement(80158..80394) 1 NC_007385.1 putative acyl carrier protein; Acp 80394 acp 3670830 acp Shigella sonnei Ss046 Acp YP_313341.1 80158 R 300269 CDS YP_313342.1 74314924 3670831 complement(80398..82299) 1 NC_007385.1 secreted by the Mxi-Spa machinery; modulates entry of bacteria into epithelial cells; IpaA 82299 ipaA 3670831 ipaA Shigella sonnei Ss046 IpaA YP_313342.1 80398 R 300269 CDS YP_313343.1 74314925 3670832 complement(82308..83306) 1 NC_007385.1 secreted by the Mxi-Spa machinery; required for entry of bacteria into epithelial cells; IpaD 83306 ipaD 3670832 ipaD Shigella sonnei Ss046 IpaD YP_313343.1 82308 R 300269 CDS YP_313344.1 74314926 3670833 complement(83357..84448) 1 NC_007385.1 secreted by the Mxi-Spa secretion machinery; required for entry into epithelial cells; IpaC 84448 ipaC 3670833 ipaC Shigella sonnei Ss046 IpaC YP_313344.1 83357 R 300269 CDS YP_313345.1 74314927 3670834 complement(84468..86210) 1 NC_007385.1 secreted by the Mxi-Spa secretion machinery; required for entry into epithelial cells; IpaB 86210 ipaB 3670834 ipaB Shigella sonnei Ss046 IpaB YP_313345.1 84468 R 300269 CDS YP_313346.1 74314928 3670835 complement(86216..86683) 1 NC_007385.1 cytoplasmic chaperone for IpaB and IpaC; IpgC 86683 ipgC 3670835 ipgC Shigella sonnei Ss046 IpgC YP_313346.1 86216 R 300269 CDS YP_313347.1 74314929 3670836 complement(86741..87367) 1 NC_007385.1 secreted by the Mxi-Spa machinery; IpgB1 87367 ipgB1 3670836 ipgB1 Shigella sonnei Ss046 IpgB1 YP_313347.1 86741 R 300269 CDS YP_313348.1 74314930 3670837 complement(87383..87772) 1 NC_007385.1 similar to IpgE; putative chaperone; IpgA 87772 ipgA 3670837 ipgA Shigella sonnei Ss046 IpgA YP_313348.1 87383 R 300269 CDS YP_313349.1 74314931 3670838 complement(87785..89269) 1 NC_007385.1 invasion protein; IcsB 89269 icsB 3670838 icsB Shigella sonnei Ss046 IcsB YP_313349.1 87785 R 300269 CDS YP_313350.1 74314932 3670839 89583..91199 1 NC_007385.1 secreted by the Mxi-Spa machinery; modulates entry of bacteria into epithelial cells; IpgD 91199 ipgD 3670839 ipgD Shigella sonnei Ss046 IpgD YP_313350.1 89583 D 300269 CDS YP_313351.1 74314933 3670840 91209..91571 1 NC_007385.1 cytoplasmic chaperone for IpgD; IpgE 91571 ipgE 3670840 ipgE Shigella sonnei Ss046 IpgE YP_313351.1 91209 D 300269 CDS YP_313352.1 74314934 3670841 91571..92029 1 NC_007385.1 periplasmic protein; similar to the catalytic site of lyzozymes; IpgF 92029 ipgF 3670841 ipgF Shigella sonnei Ss046 IpgF YP_313352.1 91571 D 300269 CDS YP_313353.1 74314935 3670842 92038..93153 1 NC_007385.1 component of the Mxi-Spa secretion machinery, contains one transmembrane segment; MxiG 93153 mxiG 3670842 mxiG Shigella sonnei Ss046 MxiG YP_313353.1 92038 D 300269 CDS YP_313354.1 74314936 3670843 93161..93412 1 NC_007385.1 component of the Mxi-Spa secretion machinery; MxiH 93412 mxiH 3670843 mxiH Shigella sonnei Ss046 MxiH YP_313354.1 93161 D 300269 CDS YP_313355.1 74314937 3670844 93425..93718 1 NC_007385.1 component of the Mxi-Spa secretion machinery; MxiI 93718 mxiI 3670844 mxiI Shigella sonnei Ss046 MxiI YP_313355.1 93425 D 300269 CDS YP_313356.1 74314938 3670845 93724..94449 1 NC_007385.1 lipoprotein, component of the Mxi-Spa secretion machinery; MxiJ 94449 mxiJ 3670845 mxiJ Shigella sonnei Ss046 MxiJ YP_313356.1 93724 D 300269 CDS YP_313357.1 74314939 3670846 94446..94973 1 NC_007385.1 putative component of the Mxi-Spa secretion machinery; MxiK 94973 mxiK 3670846 mxiK Shigella sonnei Ss046 MxiK YP_313357.1 94446 D 300269 CDS YP_313358.1 74314940 3670847 94915..95610 1 NC_007385.1 putative component of the Mxi-Spa secretion machinery; MxiN 95610 mxiN 3670847 mxiN Shigella sonnei Ss046 MxiN YP_313358.1 94915 D 300269 CDS YP_313359.1 74314941 3670848 95603..96010 1 NC_007385.1 secreted by and putative component of the Mxi-Spa secretion machinery; MxiL 96010 mxiL 3670848 mxiL Shigella sonnei Ss046 MxiL YP_313359.1 95603 D 300269 CDS YP_313360.1 74314942 3670849 95994..96422 1 NC_007385.1 lipoprotein; component of the Mxi-Spa secretion machinery; MxiM 96422 mxiM 3670849 mxiM Shigella sonnei Ss046 MxiM YP_313360.1 95994 D 300269 CDS YP_313361.1 74314943 3670850 96552..97184 1 NC_007385.1 similar to transcriptional activators of the AraC family; MxiE 97184 mxiE 3670850 mxiE Shigella sonnei Ss046 MxiE YP_313361.1 96552 D 300269 CDS YP_313362.1 74314944 3670851 97171..98871 1 NC_007385.1 outermembrane protein of the secretin family; component of the Mxi-Spa secretion machinery; MxiD 98871 mxiD 3670851 mxiD Shigella sonnei Ss046 MxiD YP_313362.1 97171 D 300269 CDS YP_313363.1 74314945 3670852 98890..99957 1 NC_007385.1 secreted by and putative component of the Mxi-Spa secretion machinery; similar to YopN (secreted by the type III secretion machinery of Yersinia enterocoltica); MxiC 99957 mxiC 3670852 mxiC Shigella sonnei Ss046 MxiC YP_313363.1 98890 D 300269 CDS YP_313364.1 74314946 3670853 99964..102030 1 NC_007385.1 innermembrane protein; component of the Mxi-Spa secretion machinery; MxiA 102030 mxiA 3670853 mxiA Shigella sonnei Ss046 MxiA YP_313364.1 99964 D 300269 CDS YP_313365.1 74314947 3670854 102043..102444 1 NC_007385.1 putative component of the Mxi-Spa secretion machinery; Spa15 102444 spa15 3670854 spa15 Shigella sonnei Ss046 Spa15 YP_313365.1 102043 D 300269 CDS YP_313366.1 74314948 3670855 102448..103740 1 NC_007385.1 component of the Mxi-Spa secretion machinery; putative ATPase; Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase; ATP synthase SpaL 103740 spa47 3670855 spa47 Shigella sonnei Ss046 ATP synthase SpaL YP_313366.1 102448 D 300269 CDS YP_313367.1 74314949 3670856 103833..104171 1 NC_007385.1 component of the Mxi-Spa secretion machinery; Spa13 104171 spa13 3670856 spa13 Shigella sonnei Ss046 Spa13 YP_313367.1 103833 D 300269 CDS YP_313368.1 74314950 3670857 104158..105036 1 NC_007385.1 secreted by and component of the Mxi-Spa machinery; Spa32 105036 spa32 3670857 spa32 Shigella sonnei Ss046 Spa32 YP_313368.1 104158 D 300269 CDS YP_313369.1 74314951 3670858 105030..105911 1 NC_007385.1 component of the Mxi-Spa secretion machinery; Spa33 105911 spa33 3670858 spa33 Shigella sonnei Ss046 Spa33 YP_313369.1 105030 D 300269 CDS YP_313370.1 74314952 3670859 105916..106566 1 NC_007385.1 component of the Mxi-Spa secretion machinery; part of a type III secretory system probably involved in invasion into eukaryotic cells; surface presentation of antigens protein SpaP 106566 spaP 3670859 spaP Shigella sonnei Ss046 surface presentation of antigens protein SpaP YP_313370.1 105916 D 300269 CDS YP_001449233.1 157042766 5563329 106581..106841 1 NC_007385.1 component of the Mxi-Spa secretion machinery; Spa9 106841 spa9 5563329 spa9 Shigella sonnei Ss046 Spa9 YP_001449233.1 106581 D 300269 CDS YP_313371.1 74314953 3670860 106841..107611 1 NC_007385.1 component of the Mxi-Spa secretion machinery; Spa29 107611 spa29 3670860 spa29 Shigella sonnei Ss046 Spa29 YP_313371.1 106841 D 300269 CDS YP_313372.1 74314954 3670861 107618..108646 1 NC_007385.1 component of the Mxi-Spa secretion machinery; Required for surface presentation of invasion plasmid antigens; required for invasion and for secretion of the three ipa proteins; surface presentation of antigens protein SpaS 108646 spa40 3670861 spa40 Shigella sonnei Ss046 surface presentation of antigens protein SpaS YP_313372.1 107618 D 300269 CDS YP_313373.1 74314955 3670862 108668..108901 1 NC_007385.1 hypothetical protein 108901 3670862 SSON_P118 Shigella sonnei Ss046 hypothetical protein YP_313373.1 108668 D 300269 CDS YP_313374.1 74314956 3670863 complement(109478..110098) 1 NC_007385.1 IS600 ORF2 110098 3670863 SSON_P119 Shigella sonnei Ss046 IS600 ORF2 YP_313374.1 109478 R 300269 CDS YP_313375.1 74314957 3670864 complement(110239..110541) 1 NC_007385.1 IS600 ORF1 110541 3670864 SSON_P120 Shigella sonnei Ss046 IS600 ORF1 YP_313375.1 110239 R 300269 CDS YP_313376.1 74314958 3670865 110830..112365 1 NC_007385.1 putative transposase 112365 3670865 SSON_P121 Shigella sonnei Ss046 putative transposase YP_313376.1 110830 D 300269 CDS YP_313377.1 74314959 3670866 112382..113137 1 NC_007385.1 putative transposase 113137 3670866 SSON_P122 Shigella sonnei Ss046 putative transposase YP_313377.1 112382 D 300269 CDS YP_313378.1 74314960 3670867 113272..113460 1 NC_007385.1 IS600 ORF2 113460 3670867 SSON_P123 Shigella sonnei Ss046 IS600 ORF2 YP_313378.1 113272 D 300269 CDS YP_313379.1 74314961 3670868 complement(113457..113840) 1 NC_007385.1 IS3 ORF2 113840 3670868 SSON_P124 Shigella sonnei Ss046 IS3 ORF2 YP_313379.1 113457 R 300269 CDS YP_313380.1 74314962 3670869 complement(113837..114136) 1 NC_007385.1 IS3 ORF1 114136 3670869 SSON_P125 Shigella sonnei Ss046 IS3 ORF1 YP_313380.1 113837 R 300269 CDS YP_313381.1 74314963 3670870 complement(115155..115871) 1 NC_007385.1 hypothetical protein 115871 3670870 SSON_P126 Shigella sonnei Ss046 hypothetical protein YP_313381.1 115155 R 300269 CDS YP_313382.1 74314964 3670871 complement(116456..116656) 1 NC_007385.1 putative transposase, fragment 116656 3670871 SSON_P127 Shigella sonnei Ss046 putative transposase, fragment YP_313382.1 116456 R 300269 CDS YP_313383.1 74314965 3670872 complement(116887..117219) 1 NC_007385.1 hypothetical protein 117219 3670872 SSON_P128 Shigella sonnei Ss046 hypothetical protein YP_313383.1 116887 R 300269 CDS YP_313384.1 74314966 3670873 117401..117727 1 NC_007385.1 IS629 ORF1 117727 3670873 SSON_P129 Shigella sonnei Ss046 IS629 ORF1 YP_313384.1 117401 D 300269 CDS YP_313385.1 74314967 3670874 117727..118179 1 NC_007385.1 IS629 ORF2 118179 3670874 SSON_P130 Shigella sonnei Ss046 IS629 ORF2 YP_313385.1 117727 D 300269 CDS YP_313386.1 74314968 3670875 118277..119425 1 NC_007385.1 IS21 ORF1 119425 3670875 SSON_P131 Shigella sonnei Ss046 IS21 ORF1 YP_313386.1 118277 D 300269 CDS YP_313387.1 74314969 3670876 119425..120222 1 NC_007385.1 IS21 ORF2 120222 3670876 SSON_P132 Shigella sonnei Ss046 IS21 ORF2 YP_313387.1 119425 D 300269 CDS YP_313388.1 74314970 3670877 120320..120748 1 NC_007385.1 IS629 ORF2 120748 3670877 SSON_P133 Shigella sonnei Ss046 IS629 ORF2 YP_313388.1 120320 D 300269 CDS YP_313389.1 74314971 3670878 complement(120751..120978) 1 NC_007385.1 putative transposase, fragment 120978 3670878 SSON_P134 Shigella sonnei Ss046 putative transposase, fragment YP_313389.1 120751 R 300269 CDS YP_313390.1 74314972 3670879 complement(121226..121582) 1 NC_007385.1 IS91 orf 121582 3670879 SSON_P135 Shigella sonnei Ss046 IS91 orf YP_313390.1 121226 R 300269 CDS YP_313391.1 74314973 3670880 complement(121582..122004) 1 NC_007385.1 putative IS91 ORF2 122004 3670880 SSON_P136 Shigella sonnei Ss046 putative IS91 ORF2 YP_313391.1 121582 R 300269 CDS YP_313392.1 74314974 3670881 complement(122667..122906) 1 NC_007385.1 putative reverse transcriptase, fragment 122906 3670881 SSON_P137 Shigella sonnei Ss046 putative reverse transcriptase, fragment YP_313392.1 122667 R 300269 CDS YP_313393.1 74314975 3670882 complement(122938..123138) 1 NC_007385.1 putative reverse transcriptase, fragment 123138 3670882 SSON_P138 Shigella sonnei Ss046 putative reverse transcriptase, fragment YP_313393.1 122938 R 300269 CDS YP_313394.1 74314976 3670883 complement(123053..123295) 1 NC_007385.1 IS3 ORF2 123295 3670883 SSON_P139 Shigella sonnei Ss046 IS3 ORF2 YP_313394.1 123053 R 300269 CDS YP_313395.1 74314977 3670884 complement(123268..123831) 1 NC_007385.1 IS629 ORF2 123831 3670884 SSON_P140 Shigella sonnei Ss046 IS629 ORF2 YP_313395.1 123268 R 300269 CDS YP_313396.1 74314978 3670885 complement(123938..124156) 1 NC_007385.1 IS629 ORF1 124156 3670885 SSON_P141 Shigella sonnei Ss046 IS629 ORF1 YP_313396.1 123938 R 300269 CDS YP_313397.1 74314979 3670886 complement(124335..125537) 1 NC_007385.1 secreted by the Mxi-Spa secretion machinery; VirA 125537 virA 3670886 virA Shigella sonnei Ss046 VirA YP_313397.1 124335 R 300269 CDS YP_313398.1 74314980 3670887 126066..129374 1 NC_007385.1 outermembrane protein exposed to the bacterial surface by a C-terminal autotransporter domain and involved in the movement of intracellular bacteria by binding to N-WASP; IcsA/VirG 129374 icsA/virG 3670887 icsA/virG Shigella sonnei Ss046 IcsA/VirG YP_313398.1 126066 D 300269 CDS YP_313399.1 74314981 3670888 129560..129817 1 NC_007385.1 adhesion protein, fragment 129817 3670888 SSON_P144 Shigella sonnei Ss046 adhesion protein, fragment YP_313399.1 129560 D 300269 CDS YP_313400.1 74314982 3670889 130009..130335 1 NC_007385.1 IS629 ORF1 130335 3670889 SSON_P145 Shigella sonnei Ss046 IS629 ORF1 YP_313400.1 130009 D 300269 CDS YP_313401.1 74314983 3670890 130607..131212 1 NC_007385.1 IS629 ORF2 131212 3670890 SSON_P146 Shigella sonnei Ss046 IS629 ORF2 YP_313401.1 130607 D 300269 CDS YP_313402.1 74314984 3670891 131553..133205 1 NC_007385.1 probable periplasmic UDP-sugar hydrolase; catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor 133205 ushA 3670891 ushA Shigella sonnei Ss046 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor YP_313402.1 131553 D 300269 CDS YP_313403.1 74314985 3670892 133174..133359 1 NC_007385.1 hypothetical protein 133359 3670892 SSON_P148 Shigella sonnei Ss046 hypothetical protein YP_313403.1 133174 D 300269 CDS YP_313404.1 74314986 3670893 complement(133712..134239) 1 NC_007385.1 hypothetical protein 134239 3670893 SSON_P149 Shigella sonnei Ss046 hypothetical protein YP_313404.1 133712 R 300269 CDS YP_313405.1 74314987 3670894 complement(134323..134568) 1 NC_007385.1 hypothetical protein 134568 3670894 SSON_P150 Shigella sonnei Ss046 hypothetical protein YP_313405.1 134323 R 300269 CDS YP_313406.1 74314988 3670895 complement(134538..135665) 1 NC_007385.1 putative reverse transcriptase, fragment 135665 3670895 SSON_P151 Shigella sonnei Ss046 putative reverse transcriptase, fragment YP_313406.1 134538 R 300269 CDS YP_313407.1 74314989 3670896 complement(135678..135878) 1 NC_007385.1 IS600 ORF2 135878 3670896 SSON_P152 Shigella sonnei Ss046 IS600 ORF2 YP_313407.1 135678 R 300269 CDS YP_313408.2 161986602 3670897 complement(136020..136925) 1 NC_007385.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 136925 3670897 SSON_P153 Shigella sonnei Ss046 insertion element IS2 transposase InsD YP_313408.2 136020 R 300269 CDS YP_313409.1 74314991 3670898 complement(136883..137248) 1 NC_007385.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 137248 3670898 SSON_P154 Shigella sonnei Ss046 insertion sequence 2 OrfA protein YP_313409.1 136883 R 300269 CDS YP_313410.1 74314992 3670899 complement(137447..137665) 1 NC_007385.1 putative IS orf, fragment 137665 3670899 SSON_P155 Shigella sonnei Ss046 putative IS orf, fragment YP_313410.1 137447 R 300269 CDS YP_313411.1 74314993 3670900 complement(137720..138358) 1 NC_007385.1 hypothetical protein 138358 3670900 SSON_P156 Shigella sonnei Ss046 hypothetical protein YP_313411.1 137720 R 300269 CDS YP_313412.1 74314994 3670901 139323..139556 1 NC_007385.1 IS100 ORF2 139556 3670901 SSON_P157 Shigella sonnei Ss046 IS100 ORF2 YP_313412.1 139323 D 300269 CDS YP_313413.1 74314995 3670902 complement(139608..139898) 1 NC_007385.1 hypothetical protein 139898 3670902 SSON_P158 Shigella sonnei Ss046 hypothetical protein YP_313413.1 139608 R 300269 CDS YP_313414.1 74314996 3670903 complement(139867..140118) 1 NC_007385.1 sugar phosphate transport protein-like protein 140118 3670903 SSON_P159 Shigella sonnei Ss046 sugar phosphate transport protein-like protein YP_313414.1 139867 R 300269 CDS YP_313415.1 74314997 3670904 140818..141321 1 NC_007385.1 IS1 ORF2 141321 insB 3670904 insB Shigella sonnei Ss046 IS1 ORF2 YP_313415.1 140818 D 300269 CDS YP_313416.1 74314998 3670905 141439..141912 1 NC_007385.1 hypothetical protein 141912 3670905 SSON_P161 Shigella sonnei Ss046 hypothetical protein YP_313416.1 141439 D 300269 CDS YP_313417.1 74314999 3670906 complement(141951..142748) 1 NC_007385.1 IS21 ORF2 142748 3670906 SSON_P162 Shigella sonnei Ss046 IS21 ORF2 YP_313417.1 141951 R 300269 CDS YP_313418.1 74315000 3670907 complement(142748..143674) 1 NC_007385.1 IS21 ORF1 143674 3670907 SSON_P163 Shigella sonnei Ss046 IS21 ORF1 YP_313418.1 142748 R 300269 CDS YP_313419.1 74315001 3670908 143931..144233 1 NC_007385.1 IS600 ORF1 144233 3670908 SSON_P164 Shigella sonnei Ss046 IS600 ORF1 YP_313419.1 143931 D 300269 CDS YP_313420.1 74315002 3670909 144374..145087 1 NC_007385.1 IS600 ORF2 145087 3670909 SSON_P165 Shigella sonnei Ss046 IS600 ORF2 YP_313420.1 144374 D 300269 CDS YP_313421.1 74315003 3670910 145341..145595 1 NC_007385.1 putative IS orf, fragment 145595 3670910 SSON_P166 Shigella sonnei Ss046 putative IS orf, fragment YP_313421.1 145341 D 300269 CDS YP_313422.1 74315004 3670911 146464..148101 1 NC_007385.1 secreted by the Mxi-Spa secretion machinery; invasion plasmid antigen 148101 ipaH9.8 3670911 ipaH9.8 Shigella sonnei Ss046 invasion plasmid antigen YP_313422.1 146464 D 300269 CDS YP_313423.1 74315005 3670912 148309..148578 1 NC_007385.1 hypothetical protein 148578 3670912 SSON_P168 Shigella sonnei Ss046 hypothetical protein YP_313423.1 148309 D 300269 CDS YP_313424.1 74315006 3670913 148652..148801 1 NC_007385.1 hypothetical protein 148801 yacB 3670913 yacB Shigella sonnei Ss046 hypothetical protein YP_313424.1 148652 D 300269 CDS YP_313425.1 74315007 3670914 148830..149420 1 NC_007385.1 secreted by the Mxi-Spa secretion machinery; OspG 149420 ospG 3670914 ospG Shigella sonnei Ss046 OspG YP_313425.1 148830 D 300269 CDS YP_313426.1 74315008 3670915 complement(149488..149667) 1 NC_007385.1 plasmid mobilization protein 149667 mob9 3670915 mob9 Shigella sonnei Ss046 plasmid mobilization protein YP_313426.1 149488 R 300269 CDS YP_313427.1 74315009 3670916 149825..150067 1 NC_007385.1 putative IS orf 150067 3670916 SSON_P172 Shigella sonnei Ss046 putative IS orf YP_313427.1 149825 D 300269 CDS YP_313428.1 74315010 3670917 150124..151452 1 NC_007385.1 IS4 orf 151452 3670917 SSON_P173 Shigella sonnei Ss046 IS4 orf YP_313428.1 150124 D 300269 CDS YP_313429.1 74315011 3670918 complement(151463..151705) 1 NC_007385.1 putative IS orf 151705 3670918 SSON_P174 Shigella sonnei Ss046 putative IS orf YP_313429.1 151463 R 300269 CDS YP_313430.1 74315012 3670919 151803..152021 1 NC_007385.1 IS3 ORF2 152021 3670919 SSON_P175 Shigella sonnei Ss046 IS3 ORF2 YP_313430.1 151803 D 300269 CDS YP_313431.1 74315013 3670920 complement(152009..154921) 1 NC_007385.1 hypothetical protein 154921 3670920 SSON_P176 Shigella sonnei Ss046 hypothetical protein YP_313431.1 152009 R 300269 CDS YP_313432.1 74315014 3670921 155244..155546 1 NC_007385.1 IS600 ORF1 155546 3670921 SSON_P177 Shigella sonnei Ss046 IS600 ORF1 YP_313432.1 155244 D 300269 CDS YP_313433.1 74315015 3670922 155687..156400 1 NC_007385.1 IS600 ORF2 156400 3670922 SSON_P178 Shigella sonnei Ss046 IS600 ORF2 YP_313433.1 155687 D 300269 CDS YP_313434.1 74315016 3670923 156722..157513 1 NC_007385.1 hypothetical protein 157513 3670923 SSON_P179 Shigella sonnei Ss046 hypothetical protein YP_313434.1 156722 D 300269 CDS YP_313435.1 74315017 3670924 157516..158604 1 NC_007385.1 hypothetical protein 158604 3670924 SSON_P180 Shigella sonnei Ss046 hypothetical protein YP_313435.1 157516 D 300269 CDS YP_313436.1 74315018 3670925 158609..159559 1 NC_007385.1 required for proper localization of IcsA (VirG) at the surface of bacteria; VirK 159559 virK 3670925 virK Shigella sonnei Ss046 VirK YP_313436.1 158609 D 300269 CDS YP_313437.1 74315019 3670926 159624..160568 1 NC_007385.1 probable lipid A transacetylase; Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 160568 msbB2 3670926 msbB2 Shigella sonnei Ss046 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_313437.1 159624 D 300269 CDS YP_313438.1 74315020 3670927 complement(160722..161753) 1 NC_007385.1 IS630 orf 161753 3670927 SSON_P183 Shigella sonnei Ss046 IS630 orf YP_313438.1 160722 R 300269 CDS YP_313439.1 74315021 3670928 161897..162565 1 NC_007385.1 putative transposase 162565 3670928 SSON_P184 Shigella sonnei Ss046 putative transposase YP_313439.1 161897 D 300269 CDS YP_313440.1 74315022 3670929 162929..163357 1 NC_007385.1 hypothetical protein 163357 3670929 SSON_P185 Shigella sonnei Ss046 hypothetical protein YP_313440.1 162929 D 300269 CDS YP_313441.1 74315023 3670930 163371..164087 1 NC_007385.1 IS186 ORF1 164087 3670930 SSON_P186 Shigella sonnei Ss046 IS186 ORF1 YP_313441.1 163371 D 300269 CDS YP_313442.1 74315024 3670931 164665..165012 1 NC_007385.1 putative antirestriction protein 165012 3670931 SSON_P187 Shigella sonnei Ss046 putative antirestriction protein YP_313442.1 164665 D 300269 CDS YP_313443.1 74315025 3670932 165069..165371 1 NC_007385.1 IS600 ORF1 165371 3670932 SSON_P188 Shigella sonnei Ss046 IS600 ORF1 YP_313443.1 165069 D 300269 CDS YP_313444.1 74315026 3670933 165512..166225 1 NC_007385.1 IS600 ORF2 166225 3670933 SSON_P189 Shigella sonnei Ss046 IS600 ORF2 YP_313444.1 165512 D 300269 CDS YP_313445.1 74315027 3670934 166425..168626 1 NC_007385.1 type IV secretion system coupling protein; similar to F plasmid TraD; conjugal transfer protein TraD 168626 traD 3670934 traD Shigella sonnei Ss046 conjugal transfer protein TraD YP_313445.1 166425 D 300269 CDS YP_313446.1 74315028 3670935 168626..169345 1 NC_007385.1 hypothetical protein 169345 trbH 3670935 trbH Shigella sonnei Ss046 hypothetical protein YP_313446.1 168626 D 300269 CDS YP_313447.1 74315029 3670936 169342..173625 1 NC_007385.1 cleaves origin of transfer and unwinds; oriT relaxase; conjugal transfer nickase/helicase TraI 173625 3670936 SSON_P192 Shigella sonnei Ss046 conjugal transfer nickase/helicase TraI YP_313447.1 169342 D 300269 CDS YP_313448.1 74315030 3670937 173682..173984 1 NC_007385.1 IS600 ORF1 173984 3670937 SSON_P193 Shigella sonnei Ss046 IS600 ORF1 YP_313448.1 173682 D 300269 CDS YP_313449.1 74315031 3670938 174125..174838 1 NC_007385.1 IS600 ORF2 174838 3670938 SSON_P194 Shigella sonnei Ss046 IS600 ORF2 YP_313449.1 174125 D 300269 CDS YP_313450.1 74315032 3670939 175043..175879 1 NC_007385.1 oriT nicking and unwinding protein, fragment 175879 3670939 SSON_P195 Shigella sonnei Ss046 oriT nicking and unwinding protein, fragment YP_313450.1 175043 D 300269 CDS YP_313451.1 74315033 3670941 176701..177261 1 NC_007385.1 putative fertility inhibition protein; conjugal transfer fertility inhibition protein FinO 177261 finO 3670941 finO Shigella sonnei Ss046 conjugal transfer fertility inhibition protein FinO YP_313451.1 176701 D 300269 CDS YP_313452.1 74315034 3670942 177391..177603 1 NC_007385.1 hypothetical protein 177603 yigA 3670942 yigA Shigella sonnei Ss046 hypothetical protein YP_313452.1 177391 D 300269 CDS YP_313453.1 74315035 3670943 177395..177658 1 NC_007385.1 hypothetical protein 177658 3670943 SSON_P199 Shigella sonnei Ss046 hypothetical protein YP_313453.1 177395 D 300269 CDS YP_313454.1 74315036 3670944 177847..178308 1 NC_007385.1 hypothetical protein 178308 3670944 SSON_P200 Shigella sonnei Ss046 hypothetical protein YP_313454.1 177847 D 300269 CDS YP_313455.1 74315037 3670945 178354..178563 1 NC_007385.1 putative regulator 178563 hmo 3670945 hmo Shigella sonnei Ss046 putative regulator YP_313455.1 178354 D 300269 CDS YP_313456.1 74315038 3670947 complement(178862..179365) 1 NC_007385.1 IS1 ORF2 179365 insB 3670947 insB Shigella sonnei Ss046 IS1 ORF2 YP_313456.1 178862 R 300269 CDS YP_313457.1 74315039 3670948 180209..180469 1 NC_007385.1 replication protein 180469 repB 3670948 repB Shigella sonnei Ss046 replication protein YP_313457.1 180209 D 300269 CDS YP_313458.1 74315040 3670949 180760..181617 1 NC_007385.1 RepA; replication protein 181617 repA 3670949 repA Shigella sonnei Ss046 replication protein YP_313458.1 180760 D 300269 CDS YP_313459.1 74315041 3670950 182317..182508 1 NC_007385.1 hypothetical protein 182508 3670950 SSON_P206 Shigella sonnei Ss046 hypothetical protein YP_313459.1 182317 D 300269 CDS YP_313460.1 74315042 3670951 182527..182832 1 NC_007385.1 hypothetical protein 182832 3670951 SSON_P207 Shigella sonnei Ss046 hypothetical protein YP_313460.1 182527 D 300269 CDS YP_313461.1 74315043 3670952 182829..183116 1 NC_007385.1 hypothetical protein 183116 3670952 SSON_P208 Shigella sonnei Ss046 hypothetical protein YP_313461.1 182829 D 300269 CDS YP_313462.1 74315044 3670953 complement(183349..184548) 1 NC_007385.1 IS1294 orf 184548 3670953 SSON_P209 Shigella sonnei Ss046 IS1294 orf YP_313462.1 183349 R 300269 CDS YP_313463.1 74315045 3670954 184802..185026 1 NC_007385.1 ISSfl1 ORF2 185026 3670954 SSON_P210 Shigella sonnei Ss046 ISSfl1 ORF2 YP_313463.1 184802 D 300269 CDS YP_313464.1 74315046 3670955 185165..185332 1 NC_007385.1 putative transposase 185332 3670955 SSON_P211 Shigella sonnei Ss046 putative transposase YP_313464.1 185165 D 300269 CDS YP_313465.1 74315047 3670956 complement(185350..187077) 1 NC_007385.1 secreted by the Mxi-Spa secretion machinery; invasion plasmid antigen 187077 ipaH1.4 3670956 ipaH1.4 Shigella sonnei Ss046 invasion plasmid antigen YP_313465.1 185350 R 300269 CDS YP_313467.1 74315049 3670958 complement(188127..189200) 1 NC_007385.1 IS91 orf 189200 3670958 SSON_P214 Shigella sonnei Ss046 IS91 orf YP_313467.1 188127 R 300269 CDS YP_313468.1 74315050 3670959 complement(189314..189499) 1 NC_007385.1 putative IS91 ORF2 189499 3670959 SSON_P215 Shigella sonnei Ss046 putative IS91 ORF2 YP_313468.1 189314 R 300269 CDS YP_313469.1 74315051 3670960 complement(189552..190265) 1 NC_007385.1 IS600 ORF2 190265 3670960 SSON_P216 Shigella sonnei Ss046 IS600 ORF2 YP_313469.1 189552 R 300269 CDS YP_313470.1 74315052 3670961 complement(190406..190708) 1 NC_007385.1 IS600 ORF1 190708 3670961 SSON_P217 Shigella sonnei Ss046 IS600 ORF1 YP_313470.1 190406 R 300269 CDS YP_313471.1 74315054 3670963 complement(190770..191003) 1 NC_007385.1 putative IS91 ORF2 191003 3670963 SSON_P219 Shigella sonnei Ss046 putative IS91 ORF2 YP_313471.1 190770 R 300269 CDS YP_313472.1 74315053 3670962 190993..191184 1 NC_007385.1 IS630 orf 191184 3670962 SSON_P218 Shigella sonnei Ss046 IS630 orf YP_313472.1 190993 D 300269 CDS YP_313473.1 74315055 3670964 complement(191333..192541) 1 NC_007385.1 IS1294 orf 192541 3670964 SSON_P220 Shigella sonnei Ss046 IS1294 orf YP_313473.1 191333 R 300269 CDS YP_313474.1 74315057 3670966 complement(192522..192794) 1 NC_007385.1 hypothetical protein 192794 3670966 SSON_P222 Shigella sonnei Ss046 hypothetical protein YP_313474.1 192522 R 300269 CDS YP_313475.1 74315056 3670965 192788..193063 1 NC_007385.1 IS630 orf 193063 3670965 SSON_P221 Shigella sonnei Ss046 IS630 orf YP_313475.1 192788 D 300269 CDS YP_313476.1 74315058 3670967 193478..194518 1 NC_007385.1 O antigen chain length determinant protein 194518 wzz 3670967 wzz Shigella sonnei Ss046 O antigen chain length determinant protein YP_313476.1 193478 D 300269 CDS YP_313477.1 74315059 3670968 194554..195867 1 NC_007385.1 putative UDP-glucose 6-dehydrogenase 195867 wbgT 3670968 wbgT Shigella sonnei Ss046 putative UDP-glucose 6-dehydrogenase YP_313477.1 194554 D 300269 CDS YP_313478.1 74315060 3670969 195948..196985 1 NC_007385.1 putative UDP-glucose 4-epimerase 196985 wbgU 3670969 wbgU Shigella sonnei Ss046 putative UDP-glucose 4-epimerase YP_313478.1 195948 D 300269 CDS YP_313479.1 74315061 3670970 197086..198354 1 NC_007385.1 transporter 198354 wzx 3670970 wzx Shigella sonnei Ss046 transporter YP_313479.1 197086 D 300269 CDS YP_313480.1 74315062 3670971 198423..199595 1 NC_007385.1 putative polysaccharide polymerase 199595 wzy 3670971 wzy Shigella sonnei Ss046 putative polysaccharide polymerase YP_313480.1 198423 D 300269 CDS YP_313481.1 74315063 3670972 199692..200723 1 NC_007385.1 IS630 orf 200723 3670972 SSON_P228 Shigella sonnei Ss046 IS630 orf YP_313481.1 199692 D 300269 CDS YP_313482.1 74315064 3670973 200756..202000 1 NC_007385.1 putative glycosyltransferase 202000 wbgV 3670973 wbgV Shigella sonnei Ss046 putative glycosyltransferase YP_313482.1 200756 D 300269 CDS YP_313483.1 74315065 3670974 201993..202979 1 NC_007385.1 putative glycosyltransferase 202979 wbgW 3670974 wbgW Shigella sonnei Ss046 putative glycosyltransferase YP_313483.1 201993 D 300269 CDS YP_313484.1 74315066 3670975 202976..204130 1 NC_007385.1 putative glycosyltransferase 204130 wbgX 3670975 wbgX Shigella sonnei Ss046 putative glycosyltransferase YP_313484.1 202976 D 300269 CDS YP_313485.1 74315067 3670976 204147..204737 1 NC_007385.1 putative glycosyltransferase 204737 wbgY 3670976 wbgY Shigella sonnei Ss046 putative glycosyltransferase YP_313485.1 204147 D 300269 CDS YP_313486.1 74315068 3670977 204752..206671 1 NC_007385.1 putative epimerase/dehydratase 206671 wbgZ 3670977 wbgZ Shigella sonnei Ss046 putative epimerase/dehydratase YP_313486.1 204752 D 300269 CDS YP_313487.1 74315069 3670978 206790..207302 1 NC_007385.1 putative aquaporin 207302 3670978 SSON_P234 Shigella sonnei Ss046 putative aquaporin YP_313487.1 206790 D 300269 CDS YP_313488.1 74315070 3670979 207506..207781 1 NC_007385.1 IS629 ORF1 207781 3670979 SSON_P235 Shigella sonnei Ss046 IS629 ORF1 YP_313488.1 207506 D 300269 CDS YP_313489.1 74315071 3670980 complement(207903..208172) 1 NC_007385.1 putative transposase 208172 3670980 SSON_P236 Shigella sonnei Ss046 putative transposase YP_313489.1 207903 R 300269 CDS YP_313490.1 74315072 3670981 complement(208316..209389) 1 NC_007385.1 IS91 orf 209389 3670981 SSON_P237 Shigella sonnei Ss046 IS91 orf YP_313490.1 208316 R 300269 CDS YP_313491.1 74315073 3670982 complement(209503..209868) 1 NC_007385.1 putative IS91 ORF2 209868 3670982 SSON_P238 Shigella sonnei Ss046 putative IS91 ORF2 YP_313491.1 209503 R 300269 CDS YP_313492.1 74315074 3670983 209915..210772 1 NC_007385.1 IS911 ORF2 210772 3670983 SSON_P239 Shigella sonnei Ss046 IS911 ORF2 YP_313492.1 209915 D 300269 CDS YP_313493.1 74315075 3670984 complement(210796..211488) 1 NC_007385.1 hypothetical protein 211488 3670984 SSON_P240 Shigella sonnei Ss046 hypothetical protein YP_313493.1 210796 R 300269 CDS YP_313494.1 74315076 3670985 213078..214025 1 NC_007385.1 outermembrane protease of the OmpP family; involved in cleavage of surface exposed IcsA; outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA; outer membrane protease 214025 icsP/sopA 3670985 icsP/sopA Shigella sonnei Ss046 outer membrane protease YP_313494.1 213078 D 300269 CDS YP_001139952.1 145294026 4991505 complement(474..1124) 1 NC_009345.1 tetracycline resistance repressor protein; hypothetical protein 1124 tetR 4991505 tetR Shigella sonnei Ss046 hypothetical protein YP_001139952.1 474 R 300269 CDS YP_001139953.1 145294027 4991506 1155..2429 1 NC_009345.1 tetracycline resistance protein A; TetA 2429 tetA 4991506 tetA Shigella sonnei Ss046 TetA YP_001139953.1 1155 D 300269 CDS YP_001139954.1 145294028 4991507 5780..6595 1 NC_009345.1 dihydropteroate synthase type II; SulII 6595 sulII 4991507 sulII Shigella sonnei Ss046 SulII YP_001139954.1 5780 D 300269 CDS YP_001139955.1 145294029 4991508 6656..7459 1 NC_009345.1 streptomycin resistance protein A; StrA 7459 strA 4991508 strA Shigella sonnei Ss046 StrA YP_001139955.1 6656 D 300269 CDS YP_001139956.1 145294030 4991509 7459..8295 1 NC_009345.1 streptomycin resistance protein B; StrB 8295 strB 4991509 strB Shigella sonnei Ss046 StrB YP_001139956.1 7459 D 300269 CDS YP_001139957.1 145294032 4991510 1..1566 1 NC_009346.1 colicin E1 protein 1566 cea 4991510 cea Shigella sonnei Ss046 colicin E1 protein YP_001139957.1 1 D 300269 CDS YP_001139958.1 145294033 4991511 complement(1563..1904) 1 NC_009346.1 colicin E1 immunity protein 1904 imm 4991511 imm Shigella sonnei Ss046 colicin E1 immunity protein YP_001139958.1 1563 R 300269 CDS YP_001139959.1 145294034 4991512 1952..2089 1 NC_009346.1 colicin E1 precursor lysis protein 2089 lys 4991512 lys Shigella sonnei Ss046 colicin E1 precursor lysis protein YP_001139959.1 1952 D 300269 CDS YP_001139960.1 145294035 4991513 complement(2372..2743) 1 NC_009346.1 hypothetical protein 2743 4991513 SSON_PB04 Shigella sonnei Ss046 hypothetical protein YP_001139960.1 2372 R 300269 CDS YP_001139961.1 145294036 4991514 complement(2931..3125) 1 NC_009346.1 RNAI modulator protein 3125 rom 4991514 rom Shigella sonnei Ss046 RNAI modulator protein YP_001139961.1 2931 R 300269 CDS YP_001139962.1 145294037 4991515 3409..3732 1 NC_009346.1 plasmid mobilization protein A; hypothetical protein 3732 mobA 4991515 mobA Shigella sonnei Ss046 hypothetical protein YP_001139962.1 3409 D 300269 CDS YP_001139963.1 145294038 4991516 complement(3957..4376) 1 NC_009346.1 entry exclusion protein 2 4376 exc 4991516 exc Shigella sonnei Ss046 entry exclusion protein 2 YP_001139963.1 3957 R 300269 CDS YP_001139964.1 145294039 4991517 complement(4457..4876) 1 NC_009346.1 entry exclusion protein 1 4876 exc1 4991517 exc1 Shigella sonnei Ss046 entry exclusion protein 1 YP_001139964.1 4457 R 300269 CDS YP_001139965.1 145294041 4991518 703..1668 1 NC_009347.1 replication protein; hypothetical protein 1668 rep 4991518 rep Shigella sonnei Ss046 hypothetical protein YP_001139965.1 703 D 300269 CDS