-- dump date   	20140620_065557
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
YP_309034.1	involved in threonine biosynthesis; controls the expression of the thrLABC operon
YP_309035.1	homoserine dehydrogenase I; multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways
YP_309036.1	catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate
YP_309037.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine
YP_309039.1	Code: S; COG: COG3022
YP_309040.1	Code: L; COG: COG1662
YP_309041.1	Code: G; COG: COG0176
YP_309042.1	forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis
YP_309043.1	Code: S; COG: COG1584
YP_309044.1	Code: S; COG: COG4735
YP_309046.1	DNA biosynthesis; autoregulated heat shock proteins; heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_309047.1	heat shock protein; chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion
YP_309049.1	Code: L; COG: COG3547
YP_309050.1	Code: L; COG: COG4584
YP_309051.1	Code: L; COG: COG1484
YP_309053.1	exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH
YP_309054.1	Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC
YP_309057.1	Code: L; COG: COG1662
YP_309060.1	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase
YP_309062.1	catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities
YP_309063.1	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme
YP_309064.1	SPase II; lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis
YP_309065.1	a rotamase; Code: O; COG: COG1047
YP_309066.1	involved in penicillin tolerance; catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway
YP_309067.1	catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides
YP_309068.1	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis
YP_309069.1	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
YP_309070.1	four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity
YP_309071.1	Code: L; COG: COG1662
YP_309072.2	regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons
YP_309073.1	involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities
YP_309074.1	catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA
YP_309075.1	Code: IQ; COG: COG0318
YP_309076.1	Code: L; COG: COG2963
YP_309077.1	Code: L; COG: COG2801
YP_309078.1	catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA
YP_309079.1	catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism
YP_309080.2	probable flavoprotein subunit, carnitine metabolism; required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase
YP_309081.1	probable flavoprotein subunit, carnitine metabolism; involved in electron transfer during carnitine metabolism
YP_309082.1	electron transport; FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction
YP_309083.1	Code: C; COG: COG2440
YP_309084.1	Required for full activity of KefC, a potassium-proton antiporter
YP_309085.1	glutathione-regulated; transport system that facilitates potassium-efflux
YP_309086.1	trimethoprim resistance; catalyzes the reduction of dihydrofolate to tetrahydrofolate
YP_309087.1	hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP
YP_309088.1	protein associated with Co2+ and Mg2+ efflux
YP_309089.1	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_309090.1	catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate)
YP_309091.1	Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB
YP_309092.1	determines N-hexane tolerance and is involved in outer membrane permeability
YP_309093.1	functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system
YP_309094.1	catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs
YP_309095.1	transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA
YP_309096.1	Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C
YP_309097.1	catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
YP_309098.1	catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism
YP_309099.1	catalyzes the phosphorylation of ribulose to ribulose 5-phosphate
YP_309100.1	positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose
YP_309101.1	Code: S; COG: COG0586
YP_309102.1	with TbpA and ThiP is part of the thiamine and TPP transport system
YP_309103.1	permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine
YP_309104.1	part of the thiamine and TPP transport system tbpA-thiPQ
YP_309105.1	activates sgrS under glucose-phosphate stress conditions
YP_309106.1	Code: GEPR; COG: COG0477
YP_309107.1	Code: L; COG: COG1662
YP_309108.1	catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D
YP_309109.1	dehydratase; dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate
YP_309110.2	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
YP_309111.1	catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis
YP_309112.1	involved in attenuation control of the leuABCD operon in leucine biosynthesis
YP_309113.2	activator for leuABCD operon; member of LysR family of transcriptional activators
YP_309114.1	catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive
YP_309115.1	with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit
YP_309117.1	binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism
YP_309118.1	Code: L; COG: COG1662
YP_309119.1	MraZ; UPF0040; crystal structure shows similarity to AbrB
YP_309120.1	Code: M; COG: COG0275
YP_309121.1	ingrowth of wall at septum; membrane bound cell division protein at septum containing leucine zipper motif
YP_309122.1	Code: M; COG: COG0768
YP_309123.1	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate
YP_309124.1	Code: M; COG: COG0770
YP_309125.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_309126.1	UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation
YP_309127.1	membrane protein involved in shape determination; integral membrane protein involved in stabilizing FstZ ring during cell division
YP_309128.1	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis
YP_309129.1	Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis
YP_309130.1	affects cell division; D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_309131.1	ingrowth of wall at septum; involved in septum formation
YP_309132.1	septation process; complexes with FtsZ; associated with junctions of inner and outer membranes; ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane
YP_309133.1	cell division; forms circumferential ring; tubulin-like GTP-binding protein and GTPase; GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function
YP_309134.1	lipid A biosynthesis; zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis
YP_309135.2	secM translational pause allows for the initiation of secA translation
YP_309136.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins
YP_309137.1	prefers dGTP; causes AT-GC transversions; Code: LR; COG: COG0494
YP_309139.1	Code: S; COG: COG3024
YP_309140.1	Code: S; COG: COG4582
YP_309141.1	catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis
YP_309142.1	catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate
YP_309144.1	involved in biogenesis of fimbriae, protein transport, DNA uptake; Code: NU; COG: COG1459
YP_309145.1	Code: NU; COG: COG4969
YP_309146.1	catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide
YP_309147.1	Code: V; COG: COG3023
YP_309148.1	involved in regulation of beta-lactamase; signaling protein
YP_309149.1	Code: E; COG: COG1113
YP_309150.1	activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex
YP_309151.1	E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC
YP_309152.1	E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains
YP_309153.1	component of 2-oxodehydrogenase and pyruvate complexes; L-protein of glycine cleavage complex; E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide
YP_309155.1	catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate
YP_309156.1	Code: S; COG: COG3112
YP_309157.1	S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine
YP_309158.1	putrescine aminopropyltransferase; catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine
YP_309160.1	laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification
YP_309161.1	Code: G; COG: COG4993
YP_309162.2	Code: F; COG: COG0634
YP_309163.1	catalyzes the interconversion of bicarbonate and carbon dioxide
YP_309164.1	Code: V; COG: COG1131
YP_309165.1	Code: V; COG: COG0842
YP_309166.1	Code: G; COG: COG2893
YP_309167.1	Code: G; COG: COG0726
YP_309168.1	Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5)
YP_309169.1	Code: S; COG: COG5464
YP_309170.1	catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine
YP_309171.1	catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate
YP_309172.1	Code: L; COG: COG1662
YP_309173.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_309176.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_309177.2	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_309178.1	Code: L; COG: COG3335
YP_309179.1	Code: L; COG: COG1662
YP_309180.1	Code: NU; COG: COG3121
YP_309181.1	Code: NU; COG: COG3539
YP_309182.1	catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP
YP_309183.2	Polymerase that creates the 3' poly(A) tail found in some mRNA's
YP_309184.2	this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu
YP_309185.1	Code: T; COG: COG1734
YP_309186.1	Regulatory factor involved in maltose metabolism
YP_309187.1	Code: J; COG: COG1514
YP_309188.1	similar in sequence to the ATP-dependent RNA helicase HrpA
YP_309189.1	penicillin-binding protein 1B; bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell
YP_309190.1	involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein
YP_309191.1	part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter
YP_309192.1	Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores
YP_309193.1	part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome
YP_309194.1	Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway
YP_309195.1	Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation
YP_309196.1	essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors
YP_309197.1	Code: S; COG: COG2860
YP_309198.1	solute binding component of the vitamin B12 transport system BtuCDF
YP_309199.1	enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine
YP_309200.1	Code: L; COG: COG1662
YP_309201.1	heat shock protein HtrA; protease Do; required at high temperature; degrades damaged proteins
YP_309202.2	regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization
YP_309204.2	Code: R; COG: COG1408
YP_309205.1	catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway
YP_309206.1	uridylyltransferase acts on regulator of glnA; catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein
YP_309207.1	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn
YP_309208.1	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit
YP_309209.1	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu
YP_309210.1	Catalyzes the phosphorylation of UMP to UDP
YP_309211.1	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs
YP_309212.1	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate
YP_309213.1	catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate
YP_309214.2	catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate
YP_309215.1	catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response
YP_309216.1	part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins
YP_309217.1	located in outer membrane or nucleoid; Code: M; COG: COG2825
YP_309218.1	third step of endotoxin (lipidA) synthesis; adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis
YP_309219.1	in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP
YP_309220.1	catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis
YP_309221.1	lipid A biosynthesis, penultimate step; catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM
YP_309222.1	degrades RNA of DNA-RNA hybrids; RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_309223.1	catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase
YP_309224.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein
YP_309225.1	Code: L; COG: COG3385
YP_309226.1	Code: E; COG: COG1982
YP_309227.2	Code: E; COG: COG0346
YP_309228.1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase
YP_309229.1	Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination
YP_309231.1	Code: S; COG: COG4681
YP_309232.1	lipoprotein; Code: MP; COG: COG3015
YP_309234.1	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_309235.1	Code: S; COG: COG1720
YP_309237.1	Code: P; COG: COG1464
YP_309238.1	part of the MetNIQ methionine uptake system
YP_309239.1	part of the metNIQ transport system for methionine
YP_309240.1	Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate
YP_309241.1	catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid
YP_309242.1	Code: K; COG: COG0583
YP_309243.1	Code: S; COG: COG3021
YP_309244.1	Code: QR; COG: COG0500
YP_309245.1	catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall
YP_309246.1	catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione
YP_309247.1	Code: QR; COG: COG0500
YP_309248.1	degrades RNA of DNA-RNA hybrids; participates in DNA replication; An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids
YP_309249.1	3'-5' exonuclease of DNA polymerase III
YP_309252.1	Code: S; COG: COG3157
YP_309253.1	Code: S; COG: COG3515
YP_309256.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_309257.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_309259.1	Code: S; COG: COG3515
YP_309261.1	Code: O; COG: COG0542
YP_309263.1	Code: S; COG: COG3455
YP_309264.1	Code: S; COG: COG3522
YP_309266.1	Code: S; COG: COG3521
YP_309267.1	Code: T; COG: COG3456
YP_309268.1	Code: S; COG: COG3520
YP_309269.1	Code: S; COG: COG3519
YP_309271.1	Code: S; COG: COG3517
YP_309273.1	Code: S; COG: COG3516
YP_309274.1	Code: S; COG: COG3157
YP_309275.1	Code: S; COG: COG3501
YP_309276.1	Code: M; COG: COG3209
YP_309278.1	Code: L; COG: COG5433
YP_309279.1	Code: L; COG: COG5433
YP_309280.1	Code: R; COG: COG0388
YP_309281.1	inactivates vertebrate C-type lysozyme
YP_309282.2	functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA
YP_309283.1	catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate
YP_309284.1	Code: R; COG: COG0121
YP_309285.1	Code: S; COG: COG3034
YP_309286.1	Code: S; COG: COG3041
YP_309287.1	Code: L; COG: COG3077
YP_309288.1	Code: M; COG: COG0791
YP_309289.1	Code: L; COG: COG1662
YP_309290.1	Code: L; COG: COG1943
YP_309291.1	Code: NU; COG: COG1298
YP_309292.1	Code: N; COG: COG1360
YP_309293.1	tRNA synthetase; involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function
YP_309294.1	Code: KR; COG: COG0454
YP_309295.1	Code: L; COG: COG3547
YP_309296.1	similar to release factor 1 and 2
YP_309297.1	peptidase D; Code: E; COG: COG2195
YP_309298.1	catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively
YP_309299.1	forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation
YP_309300.1	involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS
YP_309301.1	Code: M; COG: COG3203
YP_309302.1	catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis
YP_309303.1	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway
YP_309304.1	Code: L; COG: COG2801
YP_309305.1	Code: L; COG: COG2963
YP_309306.1	Code: L; COG: COG3335
YP_309307.1	Code: L; COG: COG1662
YP_309309.1	Code: L; COG: COG2963
YP_309310.1	Code: L; COG: COG2801
YP_309311.1	catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family
YP_309312.1	catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate
YP_309313.1	transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer
YP_309314.1	forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon
YP_309315.1	Code: L; COG: COG1662
YP_309316.1	Code: E; COG: COG1280
YP_309318.1	Code: L; COG: COG2963
YP_309319.1	Code: L; COG: COG2801
YP_309321.1	Code: L; COG: COG1662
YP_309322.1	Code: R; COG: COG1064
YP_309323.1	metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain
YP_309324.1	Code: E; COG: COG0549
YP_309326.1	Code: C; COG: COG0074
YP_309328.1	Code: L; COG: COG1662
YP_309329.1	Code: S; COG: COG1556
YP_309330.1	Code: C; COG: COG1139
YP_309331.1	Code: C; COG: COG0247
YP_309332.1	Code: K; COG: COG2207
YP_309333.2	Involved in disulfide oxidoreductase activity and electron transport
YP_309335.1	Code: S; COG: COG3059
YP_309336.1	Code: R; COG: COG0656
YP_309337.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_309338.2	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_309339.1	Code: L; COG: COG2801
YP_309340.1	Code: L; COG: COG2963
YP_309341.2	catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid
YP_309342.1	catalyzes the formation of acetyl-CoA from acetalaldehyde
YP_309343.1	catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate
YP_309344.2	Code: GEPR; COG: COG0477
YP_309345.2	Code: S; COG: COG3122
YP_309346.1	Code: R; COG: COG0627
YP_309347.1	formaldehyde dehydrogenase, glutathione-dependent; Code: C; COG: COG1062
YP_309348.1	formaldehyde-induced negative regulator of the frmRAB operon
YP_309350.1	Code: R; COG: COG0110
YP_309351.1	Code: S; COG: COG2120
YP_309352.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_309353.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_309354.2	with TauB and TauC is responsible for taurine uptake.
YP_309355.1	Part of the ABC transporter complex tauABC involved in taurine import
YP_309356.1	Code: P; COG: COG0600
YP_309357.1	catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers
YP_309358.1	porphobilinogen synthase; catalyzes the formation of porphobilinogen from 5-aminolevulinate
YP_309360.1	similar to 3rd module of ATP-binding components of transporters; Code: MU; COG: COG3468
YP_309362.1	this protein has no known enzymatic function
YP_309363.1	in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope
YP_309367.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_309369.1	Code: P; COG: COG1785
YP_309372.1	Code: L; COG: COG1662
YP_309373.1	catalyzes the formation of L-proline from pyrroline-5-carboxylate
YP_309374.2	Code: S; COG: COG1671
YP_309375.1	type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_309378.1	Code: S; COG: COG3123
YP_309379.1	Code: L; COG: COG3385
YP_309382.1	Required for efficient pilin antigenic variation
YP_309383.2	catalyzes phosphorylation of fructose; cytosolic enzyme
YP_309384.1	member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers
YP_309385.1	with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity
YP_309386.1	with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity
YP_309387.1	sensor is PhoR (or CreC); two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB
YP_309388.1	membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB
YP_309389.1	Code: E; COG: COG1114
YP_309390.1	cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation
YP_309391.1	Code: G; COG: COG0366
YP_309392.1	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
YP_309393.1	Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step
YP_309394.1	Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr)
YP_309395.1	member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex
YP_309396.1	protein secretion; membrane protein, part of the channel; part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane
YP_309397.1	protein secretion, membrane protein; forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF
YP_309398.1	Code: V; COG: COG1403
YP_309399.1	receptor of phage T6 and colicin K; Code: M; COG: COG3248
YP_309401.1	Code: K; COG: COG1327
YP_309402.1	riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil
YP_309403.1	RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not
YP_309404.1	Regulates rRNA biosynthesis by transcriptional antitermination
YP_309405.1	catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP
YP_309406.1	hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate
YP_309407.1	Code: C; COG: COG0667
YP_309408.1	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_309409.1	farnesyldiphosphate synthase; Code: H; COG: COG0142
YP_309410.1	catalyzes the bidirectional exonucleolytic cleavage of DNA
YP_309411.1	Required for the synthesis of the thiazole moiety
YP_309412.1	Code: R; COG: COG0693
YP_309413.1	involved in thiamin biosynthesis, alternative pyrimidine biosynthesis; ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis
YP_309414.2	nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription
YP_309415.1	Code: GEPR; COG: COG0477
YP_309416.1	Code: L; COG: COG1662
YP_309418.1	Code: L; COG: COG1662
YP_309421.1	Code: S; COG: COG4453
YP_309422.1	heme O biosynthesis; converts protoheme IX and farnesyl diphosphate to heme O
YP_309423.1	Code: C; COG: COG3125
YP_309424.1	Code: C; COG: COG1845
YP_309425.1	Code: C; COG: COG0843
YP_309426.1	Code: C; COG: COG1622
YP_309427.1	in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein
YP_309428.2	Code: M; COG: COG3056
YP_309429.2	positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress
YP_309430.1	a molecular chaperone involved in cell division; Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_309431.1	heat shock protein F21.5; hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_309432.1	binds and unfolds substrates as part of the ClpXP protease
YP_309433.1	heat shock K-protein; Code: O; COG: COG0466
YP_309434.1	NS1; HU-1; histone-like DNA-binding protein
YP_309435.1	Code: O; COG: COG0760
YP_309436.1	Code: L; COG: COG2963
YP_309437.1	Code: L; COG: COG2801
YP_309438.1	Code: L; COG: COG1484
YP_309439.1	Code: L; COG: COG4584
YP_309441.1	Code: L; COG: COG1555
YP_309442.1	Code: R; COG: COG0824
YP_309443.1	YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His
YP_309444.1	Code: R; COG: COG4533
YP_309445.1	Code: R; COG: COG0561
YP_309446.1	Code: K; COG: COG1522
YP_309447.1	Code: V; COG: COG1132
YP_309448.1	Code: V; COG: COG1132
YP_309449.1	indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.
YP_309450.1	Code: P; COG: COG0004
YP_309451.1	Code: I; COG: COG1946
YP_309452.1	Code: S; COG: COG3126
YP_309453.1	Code: L; COG: COG3695
YP_309454.1	Code: S; COG: COG5507
YP_309455.1	Code: T; COG: COG4943
YP_309457.1	Code: R; COG: COG0110
YP_309458.1	with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins
YP_309460.1	Code: V; COG: COG0841
YP_309461.1	Code: M; COG: COG0845
YP_309462.1	regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine
YP_309463.1	small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS
YP_309465.1	PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks
YP_309466.1	Code: S; COG: COG2832
YP_309467.1	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis
YP_309468.1	DNA elongation factor III; catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA
YP_309469.1	Code: S; COG: COG0718
YP_309470.1	involved in a recombinational process of DNA repair, independent of the recBC complex
YP_309471.1	heat shock protein C 62.5; molecular chaperone
YP_309472.1	pleiotropic effects on glycerol-3-phosphate acyltransferase activity; essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP
YP_309473.1	final enzyme of heme biosynthesis; protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic
YP_309474.1	Code: I; COG: COG0657
YP_309475.1	Code: G; COG: COG0524
YP_309476.1	YbaL; member of the CPA-2 family of antiporters; uncharacterized protein
YP_309477.1	Code: L; COG: COG2801
YP_309478.1	Code: L; COG: COG2963
YP_309479.1	Code: GEPR; COG: COG0477
YP_309480.1	5'-nucleotidase; catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides
YP_309481.1	Code: S; COG: COG2606
YP_309482.1	Code: S; COG: COG3735
YP_309483.1	Code: R; COG: COG3093
YP_309484.1	Code: P; COG: COG2217
YP_309485.1	catalyzes the formation of glutamate from glutamine
YP_309486.1	Code: E; COG: COG0531
YP_309487.1	activator of copper-responsive regulon genes
YP_309488.1	Code: OU; COG: COG1585
YP_309489.1	Code: O; COG: COG0330
YP_309490.1	Code: R; COG: COG4619
YP_309491.1	Code: R; COG: COG0390
YP_309492.1	Code: O; COG: COG3118
YP_309493.1	Code: IQR; COG: COG1028
YP_309494.1	also functions as protease I; Code: E; COG: COG2755
YP_309495.1	Code: Q; COG: COG4181
YP_309496.1	Code: Q; COG: COG3127
YP_309497.1	catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
YP_309498.1	Code: L; COG: COG1662
YP_309499.1	5,10-methylene-tetrahydrofolate cyclohydrolase; catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate
YP_309500.2	Code: S; COG: COG2501
YP_309501.1	Code: R; COG: COG1988
YP_309502.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_309503.1	Code: O; COG: COG0652
YP_309504.1	catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine
YP_309505.1	AIR carboxylase, catalytic subunit; Code: F; COG: COG0041
YP_309506.1	AIR carboxylase, CO(2)-fixing subunit; With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
YP_309507.1	Code: E; COG: COG0549
YP_309510.1	Code: L; COG: COG1662
YP_309511.1	Code: G; COG: COG3622
YP_309512.1	Code: L; COG: COG1662
YP_309513.1	Code: NU; COG: COG3539
YP_309514.1	Code: NU; COG: COG3539
YP_309515.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_309516.1	Code: L; COG: COG1662
YP_309517.1	thermoregulation of porin biosynthesis; Code: K; COG: COG2207
YP_309519.1	Code: R; COG: COG0457
YP_309520.1	Code: L; COG: COG1662
YP_309521.1	Code: M; COG: COG3209
YP_309523.1	Code: S; COG: COG5435
YP_309524.1	Code: S; COG: COG3501
YP_309525.1	Code: T; COG: COG0642
YP_309526.1	response regulator in two-component regulatory system with CusS; regulates the copper efflux system
YP_309527.1	with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver
YP_309528.1	Code: S; COG: COG5569
YP_309529.1	with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver
YP_309530.1	Code: P; COG: COG3696
YP_309531.1	Code: E; COG: COG1113
YP_309532.1	Code: M; COG: COG0668
YP_309533.1	catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive
YP_309534.1	Code: S; COG: COG2315
YP_309535.1	ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity
YP_309536.1	Code: Q; COG: COG2977
YP_309537.1	Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space
YP_309538.1	Code: P; COG: COG2382
YP_309539.1	Code: S; COG: COG3251
YP_309540.1	may be part of enterobactin synthase as component F; with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin
YP_309541.1	enterochelin transport; part of the ferric enterobactin transport system; necessary for enetrobactin uptake
YP_309542.1	with FepBDE is involved in the transport of ferric enterobactin
YP_309543.1	with FepBCD is involved in the transport of ferric enterobactin
YP_309544.1	with FepBCG is involved in the transport of ferric enterobactin
YP_309545.1	protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters
YP_309546.1	enterochelin binding protein; with FepCDG is involved in the transport of ferric enterobactin
YP_309547.1	enterochelin biosynthesis; Code: HQ; COG: COG1169
YP_309548.1	bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate
YP_309549.1	isochroismatase; Code: Q; COG: COG1535
YP_309550.1	catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin
YP_309551.1	Code: Q; COG: COG2050
YP_309552.1	Code: T; COG: COG1966
YP_309553.1	Code: S; COG: COG2879
YP_309554.1	member of the iron-containing alcohol dehydrogenase family; unknown function
YP_309555.1	catalyzes the transfer of an amino moiety
YP_309556.1	Code: K; COG: COG1475
YP_309557.1	Code: L; COG: COG1662
YP_309558.1	Involved in disulfide bond formation
YP_309559.1	detoxification of hydroperoxides; with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate
YP_309560.1	detoxification of hydroperoxides; Code: O; COG: COG3634
YP_309561.1	Code: T; COG: COG0589
YP_309562.1	Code: ER; COG: COG1063
YP_309564.1	Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation
YP_309565.1	cleaves phosphodiester bond between any two nucleotides; Code: J; COG: COG3719
YP_309566.1	Code: P; COG: COG0471
YP_309567.1	catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA
YP_309568.1	2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate
YP_309569.1	Code: C; COG: COG3051
YP_309570.1	Code: G; COG: COG2301
YP_309571.1	acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate
YP_309572.1	Code: L; COG: COG1662
YP_309573.1	Code: T; COG: COG3290
YP_309574.1	regulates the expression of citAB in citrate fermentation
YP_309575.1	responsible for the transport of C4-dicarboxylates during anaerobic growth
YP_309576.1	Code: L; COG: COG1662
YP_309577.1	catalyzes the transfer of palmitate to lipid A
YP_309578.1	member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator
YP_309579.1	may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling
YP_309580.1	Code: R; COG: COG0388
YP_309581.1	TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes
YP_309582.1	Code: L; COG: COG3385
YP_309583.1	lipoate synthesis, possibly involved in sulfur insertion; catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group
YP_309584.1	Code: K; COG: COG0583
YP_309585.2	lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein
YP_309586.1	Code: S; COG: COG2921
YP_309587.1	penicillin-binding protein 5; penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
YP_309588.1	Code: M; COG: COG0797
YP_309589.1	sensitivity to radiation and drugs; Code: D; COG: COG0772
YP_309590.1	cell elongation e phase; penicillin-binding protein 2; Code: M; COG: COG0768
YP_309591.1	SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA
YP_309592.1	Code: S; COG: COG0799
YP_309593.1	Salmonella cobC-like protein; phosphohistidine protein; Code: G; COG: COG0406
YP_309594.1	transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria
YP_309595.1	required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA
YP_309596.1	rare lipoprotein B; involved in the assembly of LPS in the outer membrane
YP_309597.1	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase
YP_309599.1	Code: R; COG: COG0790
YP_309602.1	Code: R; COG: COG0790
YP_309605.1	Code: O; COG: COG0443
YP_309606.1	Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific
YP_309607.1	Code: E; COG: COG1126
YP_309608.1	Code: E; COG: COG0765
YP_309609.1	Code: E; COG: COG0765
YP_309610.1	Code: ET; COG: COG0834
YP_309612.1	copper homeostasis protein, inner membrane; Transfers the fatty acyl group on membrane lipoproteins
YP_309613.1	Code: P; COG: COG4535
YP_309614.1	Code: R; COG: COG0319
YP_309615.1	Code: T; COG: COG1702
YP_309616.1	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A)
YP_309617.1	catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q
YP_309620.1	functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP
YP_309621.1	Code: L; COG: COG1662
YP_309622.1	Code: G; COG: COG0647
YP_309623.1	Code: KG; COG: COG1940
YP_309624.1	catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate
YP_309625.1	catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate
YP_309626.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_309627.1	catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_309630.1	negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer
YP_309631.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_309633.1	Code: R; COG: COG0596
YP_309634.1	negative modulator of the initiation of chromosome replication
YP_309635.1	catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate
YP_309636.1	catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system
YP_309637.1	Code: E; COG: COG1982
YP_309638.1	transcriptional effector; response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport
YP_309639.1	sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein
YP_309640.1	One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex
YP_309641.1	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
YP_309642.1	catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
YP_309643.1	one of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
YP_309646.1	Code: L; COG: COG4584
YP_309647.1	Code: L; COG: COG1484
YP_309648.1	Code: M; COG: COG3209
YP_309649.1	Code: L; COG: COG1662
YP_309650.1	UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent
YP_309651.1	Code: S; COG: COG3272
YP_309652.1	Code: L; COG: COG1662
YP_309653.1	Code: E; COG: COG3104
YP_309654.1	Code: S; COG: COG0327
YP_309655.1	Code: E; COG: COG2049
YP_309656.1	Code: E; COG: COG1984
YP_309657.1	Code: R; COG: COG1540
YP_309658.1	5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity
YP_309659.1	Code: R; COG: COG3180
YP_309661.1	Code: NU; COG: COG3121
YP_309662.1	Code: NU; COG: COG3539
YP_309663.1	type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH
YP_309664.1	Code: C; COG: COG2009
YP_309665.1	Code: C; COG: COG2142
YP_309666.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol
YP_309667.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase
YP_309669.1	SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide
YP_309670.1	component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA
YP_309671.1	catalyzes the interconversion of succinyl-CoA and succinate
YP_309672.1	Catalyzes the only substrate-level phosphorylation in the TCA cycle
YP_309673.1	regulates the succiny-lCoA synthetase operon
YP_309674.1	involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_309676.1	Code: C; COG: COG1271
YP_309677.1	Code: C; COG: COG1294
YP_309678.1	Code: S; COG: COG3790
YP_309679.1	catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components
YP_309680.1	maintains integrity of cell envelope; tolerance to group A colicins; membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins
YP_309681.1	involved in the tonB-independent uptake of group A colicins; membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins
YP_309682.1	required for outer membrane integrity; inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins
YP_309683.1	involved in the tonB-independent uptake of group A colicins; forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA
YP_309684.1	Code: M; COG: COG2885
YP_309685.1	periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity
YP_309686.1	Code: L; COG: COG4584
YP_309687.1	Code: L; COG: COG1484
YP_309688.1	Code: H; COG: COG3201
YP_309689.1	involved in zinc efflux across the cytoplasmic membrane
YP_309691.1	DAHP synthetase; phenylalanine repressible; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive
YP_309692.1	2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate
YP_309693.1	mutarotase; catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose
YP_309694.1	catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism
YP_309695.1	catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P
YP_309696.1	Code: M; COG: COG1087
YP_309697.1	contains 2 ATP-binding cassettes; involved in the transport of molybdenum
YP_309698.1	represses the modABCD operon and activates the moaABCD and napFDAGHBC operons
YP_309700.1	permease; with ModCB is involved in the high-affinity transport of molybdate
YP_309701.1	part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE
YP_309702.1	Part of the ABC transporter complex modABC involved in molybdenum import
YP_309703.1	Code: L; COG: COG2963
YP_309704.1	Code: L; COG: COG2801
YP_309706.1	Code: S; COG: COG1636
YP_309708.1	Code: L; COG: COG1484
YP_309709.1	Code: L; COG: COG2963
YP_309710.1	Code: L; COG: COG2801
YP_309713.1	Code: L; COG: COG2963
YP_309714.1	Code: L; COG: COG2801
YP_309715.1	Code: L; COG: COG3547
YP_309716.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_309717.1	similar to bacteriophage lambda lysozyme; Code: R; COG: COG3772
YP_309720.1	Code: R; COG: COG1783
YP_309724.1	Code: L; COG: COG1662
YP_309725.1	catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate
YP_309726.1	Code: K; COG: COG0583
YP_309727.1	Code: L; COG: COG1662
YP_309728.1	Code: C; COG: COG1048
YP_309729.1	outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family
YP_309730.1	Code: L; COG: COG0582
YP_309731.1	Code: L; COG: COG2801
YP_309732.1	Code: L; COG: COG2963
YP_309735.1	Code: S; COG: COG4886
YP_309736.1	YbhB; similar to rat and human kinase inhibitory proteins
YP_309737.1	catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate
YP_309738.1	possible sulfur insertion; Code: H; COG: COG0502
YP_309739.1	catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine
YP_309740.1	reaction prior to pimeloyl CoA; methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth
YP_309741.1	DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium
YP_309742.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion
YP_309743.1	Code: S; COG: COG0391
YP_309744.1	together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z
YP_309745.1	Code: H; COG: COG0521
YP_309746.1	MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis
YP_309747.1	catalyzes the conversion of molybdopterin precursor Z into molybdopterin
YP_309748.1	catalyzes the conversion of molybdopterin precursor Z into molybdopterin
YP_309749.1	Code: R; COG: COG0670
YP_309750.1	Code: R; COG: COG0670
YP_309751.1	Code: I; COG: COG1502
YP_309752.1	Code: R; COG: COG3568
YP_309754.1	Code: V; COG: COG0842
YP_309755.1	Code: V; COG: COG0842
YP_309756.1	Code: V; COG: COG1131
YP_309757.1	Code: M; COG: COG0845
YP_309758.1	Code: K; COG: COG1309
YP_309759.1	this helicase is not essential cell growth
YP_309760.1	Code: S; COG: COG3236
YP_309761.1	helicase involved in DNA repair and perhaps also replication
YP_309762.1	Code: E; COG: COG0547
YP_309763.1	Code: C; COG: COG2055
YP_309765.1	Code: T; COG: COG1734
YP_309766.2	Code: S; COG: COG3128
YP_309767.1	Code: L; COG: COG3385
YP_309769.1	Code: R; COG: COG3129
YP_309770.1	Code: M; COG: COG0668
YP_309771.1	similar to ATP-binding component of ABC transporters
YP_309772.1	similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine
YP_309773.1	permease; similar to periplasmic-binding component of ABC transporters
YP_309774.1	binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage
YP_309775.1	Code: R; COG: COG5006
YP_309776.1	OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains
YP_309777.1	Code: R; COG: COG2194
YP_309778.1	Transcriptional regulator that represses the manganese transporter MntH when manganese is present
YP_309779.1	Code: P; COG: COG0471
YP_309780.1	Code: S; COG: COG1376
YP_309781.1	Code: R; COG: COG0488
YP_309782.1	Code: G; COG: COG1501
YP_309783.1	Code: GEPR; COG: COG0477
YP_309784.1	Code: K; COG: COG1609
YP_309786.1	Code: R; COG: COG0561
YP_309787.1	Code: C; COG: COG1882
YP_309788.1	Code: O; COG: COG1180
YP_309789.2	similar to transaldolase from Escherichia coli; many organisms have multiple copies
YP_309790.1	ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase
YP_309791.1	is involved in the formation of active molybdenum cofactor and the chelation of molybdenum
YP_309792.1	Code: E; COG: COG1446
YP_309793.1	with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains
YP_309794.1	Code: E; COG: COG0747
YP_309795.1	Code: EP; COG: COG0601
YP_309796.1	Code: EP; COG: COG1173
YP_309797.1	Code: L; COG: COG1662
YP_309798.1	catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit
YP_309799.1	BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing
YP_309800.1	Code: G; COG: COG2133
YP_309801.1	Code: O; COG: COG0625
YP_309802.1	Code: L; COG: COG2963
YP_309803.1	Code: L; COG: COG2801
YP_309804.1	Code: KG; COG: COG1349
YP_309805.1	Code: I; COG: COG0671
YP_309807.1	Code: R; COG: COG0561
YP_309808.1	Code: GEPR; COG: COG0477
YP_309809.1	Code: S; COG: COG3226
YP_309810.1	Code: R; COG: COG2985
YP_309812.1	functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase
YP_309813.1	YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function
YP_309814.1	NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds
YP_309815.1	responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6
YP_309817.1	permease protein; Code: E; COG: COG0687
YP_309818.2	part of the PotFGHI ATP-dependent putrescine transporter
YP_309819.1	permease; Code: E; COG: COG1176
YP_309820.1	permease; Code: E; COG: COG1177
YP_309822.1	RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA
YP_309823.1	Code: ET; COG: COG0834
YP_309824.1	with ArtPQJI acts to transport arginine across the inner membrane
YP_309825.1	with ArtPMJI transports arginine across the inner membrane
YP_309826.1	Code: ET; COG: COG0834
YP_309827.1	With ArtMQJI transports arginine across the inner membrane
YP_309828.1	induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS
YP_309830.1	Code: S; COG: COG0393
YP_309831.1	Code: V; COG: COG3023
YP_309832.1	Code: MG; COG: COG0451
YP_309833.1	Code: MG; COG: COG0702
YP_309834.1	low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine
YP_309835.1	catalyzes the formation of acetate from pyruvate
YP_309836.1	Code: C; COG: COG1018
YP_309837.2	catalyzes the reduction of hydroxylamine to ammonia and water
YP_309838.1	Code: S; COG: COG2431
YP_309839.1	Code: L; COG: COG1662
YP_309840.1	Code: L; COG: COG3593
YP_309841.1	Code: S; COG: COG2990
YP_309842.2	confers macrolide resistance via active drug efflux
YP_309843.1	with MacA is involved in the export of macrolide
YP_309844.1	inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible
YP_309845.1	Code: L; COG: COG0582
YP_309846.1	Code: L; COG: COG1662
YP_309849.1	Code: R; COG: COG3378
YP_309850.1	Code: L; COG: COG2963
YP_309851.1	Code: L; COG: COG2801
YP_309853.1	Code: L; COG: COG0629
YP_309854.1	Code: OU; COG: COG0740
YP_309857.1	Code: L; COG: COG4584
YP_309858.1	Code: L; COG: COG1484
YP_309859.1	involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA
YP_309860.1	ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates
YP_309861.1	stimulates the activities of the other two initiation factors, IF-2 and IF-3
YP_309862.1	leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys
YP_309863.1	in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c
YP_309864.1	in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c
YP_309865.1	catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding
YP_309866.1	mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system
YP_309867.1	DNA-binding membrane protein required for chromosome resolution and partitioning
YP_309868.1	participates with LolB in the incorporation of lipoprotein into the outer membrane
YP_309869.1	Code: L; COG: COG2256
YP_309870.1	also charges selenocystein tRNA with serine; catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_309871.1	Code: C; COG: COG0243
YP_309872.1	Code: C; COG: COG0437
YP_309873.1	Code: R; COG: COG3302
YP_309874.1	Code: Q; COG: COG1335
YP_309875.1	Code: GEPR; COG: COG0477
YP_309876.1	Code: L; COG: COG1662
YP_309877.1	activates pyruvate formate-lyase 1 under anaerobic conditions
YP_309878.1	Code: C; COG: COG1882
YP_309879.1	formate channel 1; Code: P; COG: COG2116
YP_309880.1	Code: S; COG: COG1944
YP_309881.1	Code: S; COG: COG2323
YP_309882.1	catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine
YP_309883.1	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
YP_309884.1	Code: L; COG: COG3385
YP_309885.1	Code: O; COG: COG0501
YP_309886.1	Catalyzes the formation of (d)CDP from ATP and (d)CMP
YP_309887.1	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins
YP_309888.1	site-specific recombination; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
YP_309889.2	Code: R; COG: COG0658
YP_309890.1	multicopy suppressor of htrB; involved in the transport of lipid A across the inner membrane
YP_309891.1	EC 1.2 enzyme; transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate
YP_309892.1	Code: S; COG: COG3214
YP_309893.1	Code: S; COG: COG2835
YP_309894.1	CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS
YP_309896.1	Code: S; COG: COG1434
YP_309897.1	involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA
YP_309898.1	killing factor KICB; acts with MukB and MukE to condense the chromosome and allow for segregation during cell division
YP_309899.1	acts with MukB and MukF to condense the chromosome and allow for segregation during cell division
YP_309900.1	involved in chromosome partitioning; SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects
YP_309901.1	Code: L; COG: COG3385
YP_309902.1	Code: S; COG: COG2989
YP_309903.1	Code: S; COG: COG3108
YP_309904.1	Code: R; COG: COG0491
YP_309905.1	catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate
YP_309906.1	outer membrane porin F; 1a; Ia; b
YP_309907.1	catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_309908.1	catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate
YP_309909.1	Code: E; COG: COG0308
YP_309910.1	part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease
YP_309911.1	part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease
YP_309912.2	part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease
YP_309913.1	Code: R; COG: COG0431
YP_309914.1	Code: L; COG: COG1662
YP_309915.1	Code: NU; COG: COG3539
YP_309916.1	Code: NU; COG: COG3121
YP_309917.1	similar to Salmonella FimH protein; Code: NU; COG: COG3539
YP_309918.1	Code: NU; COG: COG3539
YP_309919.1	Code: NU; COG: COG3539
YP_309920.1	Code: NU; COG: COG3121
YP_309921.1	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors
YP_309923.1	Code: R; COG: COG3217
YP_309924.1	catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA
YP_309925.1	Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth
YP_309926.1	Code: S; COG: COG2995
YP_309927.1	Code: R; COG: COG3008
YP_309928.1	Code: S; COG: COG3009
YP_309929.1	Code: J; COG: COG3130
YP_309930.1	catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP
YP_309931.1	Code: O; COG: COG1067
YP_309932.1	Code: S; COG: COG3120
YP_309933.1	OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d
YP_309934.1	Code: D; COG: COG5404
YP_309935.1	Code: K; COG: COG3070
YP_309936.1	Code: S; COG: COG1289
YP_309937.1	Code: S; COG: COG3304
YP_309938.1	catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand
YP_309939.2	catalyzes the formation of methylglyoxal from glycerone phosphate
YP_309940.1	Code: S; COG: COG3110
YP_309941.1	Code: L; COG: COG1662
YP_309942.1	Code: R; COG: COG1832
YP_309943.1	Code: S; COG: COG3785
YP_309944.1	catalyzes the hydrolysis of acylphosphate
YP_309945.2	transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs
YP_309946.1	Code: R; COG: COG0670
YP_309947.1	Code: L; COG: COG1662
YP_309948.1	Code: C; COG: COG1740
YP_309949.1	involved in hydrogen cycling during fermentative growth
YP_309950.1	HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1)
YP_309951.1	involved in processing hydrogenase proteins HyaA and HyaB
YP_309953.1	Code: C; COG: COG1271
YP_309954.1	Code: C; COG: COG1294
YP_309955.1	expressed during stationary phase
YP_309956.1	pH 2.5 acid phosphatase; periplasmic
YP_309957.1	Code: M; COG: COG3206
YP_309958.2	Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk
YP_309959.1	Code: M; COG: COG1596
YP_309964.1	Code: K; COG: COG1278
YP_309965.1	Code: L; COG: COG1662
YP_309966.1	similar to Salmonella cold shock protein; Code: K; COG: COG1278
YP_309967.1	suppresses fabA and ts growth mutation
YP_309969.2	regulator TorR; Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide
YP_309970.1	part of regulation of tor operon, periplasmic; periplasmic sensory protein associated with the TorRS two-component regulatory system
YP_309971.1	sensor TorS; response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes
YP_309972.1	Code: C; COG: COG3005
YP_309973.1	with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA
YP_309974.1	functions closely related to DnaJ; functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock
YP_309975.1	Code: L; COG: COG3335
YP_309980.1	affects association of trp repressor and operator; stationary phase protein that binds TrpR repressor
YP_309981.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_309983.1	Code: L; COG: COG1484
YP_309984.1	Code: L; COG: COG4584
YP_309990.1	Code: F; COG: COG2233
YP_309991.1	Code: R; COG: COG1853
YP_309992.1	Code: C; COG: COG0778
YP_309993.1	Code: R; COG: COG0596
YP_309994.1	Code: Q; COG: COG1335
YP_309995.1	Code: L; COG: COG1662
YP_309996.1	Code: K; COG: COG1309
YP_309997.1	proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein
YP_309998.1	Code: ER; COG: COG0591
YP_309999.1	Code: P; COG: COG0672
YP_310000.1	Code: P; COG: COG2822
YP_310001.1	Code: P; COG: COG2837
YP_310002.1	may be helicase; induced by P starvation; Code: T; COG: COG1702
YP_310004.1	Code: HE; COG: COG0111
YP_310005.1	Code: ER; COG: COG1387
YP_310006.1	Code: R; COG: COG3381
YP_310008.1	Code: M; COG: COG1462
YP_310009.1	nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex
YP_310010.1	chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex
YP_310011.1	Code: L; COG: COG1662
YP_310012.1	Code: L; COG: COG1662
YP_310013.1	CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface
YP_310014.1	coiled surface structures; cryptic
YP_310015.1	Code: L; COG: COG4584
YP_310016.1	Code: L; COG: COG1484
YP_310017.1	involved in autoagglutination of curliated cells; not involved in production of curli fibers
YP_310019.1	Code: R; COG: COG2110
YP_310020.1	Code: I; COG: COG1502
YP_310021.1	required for the transfer of succinyl residues to the glucan backbone
YP_310022.1	involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan
YP_310023.1	synthesis of membrane-derived oligosaccharide (MDO); necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space
YP_310024.1	Code: L; COG: COG3385
YP_310025.1	Code: R; COG: COG5645
YP_310028.1	Code: GEPR; COG: COG0477
YP_310029.1	Code: L; COG: COG3547
YP_310030.1	Code: L; COG: COG1484
YP_310031.1	Code: L; COG: COG4584
YP_310032.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_310033.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_310034.1	Code: L; COG: COG2801
YP_310035.1	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA
YP_310036.1	Code: R; COG: COG1054
YP_310037.1	Code: S; COG: COG2353
YP_310038.1	Code: C; COG: COG3038
YP_310039.1	Code: L; COG: COG1662
YP_310040.1	catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids
YP_310041.1	BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing
YP_310043.1	catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis
YP_310045.1	cofactor involved in the reduction of disulfides
YP_310046.2	Confers resistance to norfloxacin and enoxacin
YP_310047.1	Code: J; COG: COG1670
YP_310048.1	Code: S; COG: COG3132
YP_310049.1	Code: R; COG: COG0673
YP_310050.1	Code: R; COG: COG0728
YP_310051.1	Code: NUO; COG: COG3418
YP_310052.1	regulates the flagellar specific sigma28 transcription factor
YP_310053.1	required for the assembly of the flagellar basal body P-ring
YP_310054.1	with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella
YP_310055.1	with FlgF and B makes up the proximal portion of the flagellar basal body rod
YP_310056.1	acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production
YP_310057.1	the hook connects flagellar basal body to the flagellar filament
YP_310058.1	FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod
YP_310059.1	lipopolysaccharide layer ring protein; part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod
YP_310060.1	similar to Salmonella P-ring of flagella basal body; part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum
YP_310061.1	Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space
YP_310062.1	with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook
YP_310063.1	with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes
YP_310064.1	membrane attachment; mRNA turnover; maturation 5S RNA; bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase
YP_310066.1	catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA
YP_310067.2	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell
YP_310068.1	Code: R; COG: COG1399
YP_310069.1	some L32 proteins have zinc finger motifs consisting of CXXC while others do not
YP_310070.2	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY
YP_310071.1	acetylCoA ACP transacylase; FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
YP_310072.1	Code: I; COG: COG0331
YP_310073.1	catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_310074.1	carries the fatty acid chain in fatty acid biosynthesis
YP_310075.1	FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_310076.1	catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate
YP_310077.1	Code: R; COG: COG1559
YP_310078.1	catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP)
YP_310079.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
YP_310080.1	Code: L; COG: COG0084
YP_310081.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_310082.1	Code: P; COG: COG4773
YP_310083.1	Code: FGR; COG: COG0537
YP_310084.1	Code: R; COG: COG5633
YP_310085.1	Code: R; COG: COG3417
YP_310086.1	catalyzes the phosphorylation of thiamine to thiamine phosphate
YP_310087.1	hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides
YP_310088.2	Code: R; COG: COG3150
YP_310089.1	Code: C; COG: COG1252
YP_310090.1	Code: S; COG: COG3134
YP_310091.1	Code: K; COG: COG1309
YP_310093.1	Code: S; COG: COG1376
YP_310094.1	mutation frequency decline; Code: LK; COG: COG1197
YP_310095.1	Code: S; COG: COG4763
YP_310096.1	part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane
YP_310097.2	outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone
YP_310098.1	part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane
YP_310099.1	catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine
YP_310100.1	Modulates the activities of several enzymes which are inactive in their acetylated form
YP_310101.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate
YP_310102.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component
YP_310103.2	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component
YP_310104.1	functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase
YP_310105.1	catalyzes the release of the N-terminal amino acid from a tripeptide
YP_310106.1	Code: S; COG: COG2850
YP_310107.1	Code: T; COG: COG0642
YP_310108.1	response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress
YP_310109.1	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide
YP_310110.1	HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis
YP_310111.2	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs
YP_310112.1	Code: LR; COG: COG0494
YP_310113.1	catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA
YP_310114.1	Converts isocitrate to alpha ketoglutarate
YP_310116.1	Code: R; COG: COG5562
YP_310117.1	Code: K; COG: COG0789
YP_310118.1	Code: L; COG: COG1662
YP_310119.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_310122.1	reverses MinC inhibition of ftsZ ring formation; works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell
YP_310123.1	a membrane ATPase; activates minC; ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums
YP_310124.1	inhibits ftsZ ring formation; blocks the formation of polar Z-ring septums
YP_310127.1	Code: S; COG: COG3100
YP_310128.1	Code: Q; COG: COG0179
YP_310129.2	Code: S; COG: COG2983
YP_310130.1	Code: L; COG: COG1662
YP_310131.1	Code: L; COG: COG1662
YP_310132.1	SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC; binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization
YP_310133.1	Code: L; COG: COG3547
YP_310134.1	disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein
YP_310135.1	involved in regulation of intracellular pH under alkaline conditions
YP_310136.1	Multifunctional regulator of fatty acid metabolism
YP_310137.1	Code: S; COG: COG2719
YP_310138.1	catalyzes the oxidative deamination of D-amino acids
YP_310139.1	catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA
YP_310140.2	the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli
YP_310141.1	catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine
YP_310142.1	Code: M; COG: COG0741
YP_310143.1	Code: M; COG: COG5581
YP_310144.1	Code: S; COG: COG2261
YP_310145.1	Code: L; COG: COG2963
YP_310146.1	Code: L; COG: COG2801
YP_310147.1	Code: L; COG: COG2801
YP_310148.1	Code: L; COG: COG2963
YP_310149.1	Code: N; COG: COG1344
YP_310150.1	flagellar biosynthesis; regulation of flagellar operons; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes
YP_310151.1	Code: L; COG: COG1662
YP_310152.1	Code: ET; COG: COG0834
YP_310153.1	Code: L; COG: COG3335
YP_310154.1	catalyzes the formation of pyruvate from D-cysteine
YP_310155.1	Code: E; COG: COG0765
YP_310156.1	Code: E; COG: COG1126
YP_310157.1	regulates genes involved in cell division
YP_310159.1	in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system
YP_310160.2	repair of UV damage to DNA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_310161.1	Code: I; COG: COG0558
YP_310162.1	Code: R; COG: COG3318
YP_310163.1	Code: E; COG: COG0814
YP_310165.1	an iron storage protein; cytoplasmic iron storage protein
YP_310168.1	Code: P; COG: COG1528
YP_310169.1	Code: G; COG: COG1879
YP_310170.1	Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose
YP_310171.1	Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose
YP_310172.1	biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature
YP_310173.1	Code: G; COG: COG0380
YP_310174.1	ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress
YP_310175.1	Code: L; COG: COG2801
YP_310176.1	Code: L; COG: COG2963
YP_310177.1	acting on class 2 operons; transcriptional initiation factor; with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems
YP_310178.1	acting on class 2 operons; transcription initiation factor; With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems
YP_310179.1	no effect on switching; With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
YP_310180.1	enables flagellar motor rotation, linking torque machinery to cell wall; with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
YP_310181.1	chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component
YP_310182.1	Code: NT; COG: COG0835
YP_310183.1	aspartate sensor receptor; Code: NT; COG: COG0840
YP_310184.1	peptide sensor receptor; mediates taxis toward dipeptides
YP_310185.1	methylates the MCP
YP_310186.1	cheA sensor; protein methylesterase; regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins
YP_310187.1	chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble
YP_310188.1	cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation
YP_310190.1	Code: L; COG: COG1662
YP_310192.1	membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export
YP_310193.1	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase
YP_310194.1	Code: S; COG: COG3102
YP_310195.1	Code: P; COG: COG3142
YP_310196.1	Code: C; COG: COG3005
YP_310197.1	Code: L; COG: COG2963
YP_310198.1	Code: L; COG: COG2801
YP_310199.1	Code: C; COG: COG0243
YP_310200.1	Code: QR; COG: COG0500
YP_310201.1	Code: QR; COG: COG0500
YP_310202.2	Code: R; COG: COG3788
YP_310203.1	Code: L; COG: COG1961
YP_310205.1	Code: L; COG: COG2963
YP_310206.1	Code: L; COG: COG2801
YP_310208.1	similar to protein of cryptic prophage
YP_310209.1	Code: L; COG: COG4570
YP_310211.1	Code: L; COG: COG1484
YP_310212.1	Code: L; COG: COG4584
YP_310213.1	Code: L; COG: COG2963
YP_310214.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_310215.1	Code: L; COG: COG2963
YP_310216.1	Code: L; COG: COG1662
YP_310217.1	Code: L; COG: COG2801
YP_310220.1	Code: S; COG: COG4886
YP_310222.2	Code: Q; COG: COG1335
YP_310223.1	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes
YP_310224.1	converts dATP to dAMP and pyrophosphate
YP_310225.1	Code: S; COG: COG0217
YP_310226.1	resolution of structures; repair; endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity
YP_310228.1	branch migration; repair; plays an essential role in ATP-dependent branch migration of the Holliday junction
YP_310229.1	branch migration; repair; promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
YP_310230.1	involved in transport of zinc(II) with ZnuA and C
YP_310231.1	involved in transport of zinc(II) with ZnuA and C
YP_310232.2	involved in transport of zinc(II) with ZnuA and C
YP_310233.2	Code: M; COG: COG0739
YP_310234.1	Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA
YP_310236.1	Code: L; COG: COG1662
YP_310240.1	Code: L; COG: COG1662
YP_310242.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_310243.1	Represses the expression of the zwf, eda, glp and gap
YP_310244.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_310245.1	catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate
YP_310246.1	catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate
YP_310247.1	non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis
YP_310248.1	Code: S; COG: COG3141
YP_310249.1	secreted protein; unknown function
YP_310250.1	Code: S; COG: COG2979
YP_310251.1	PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues
YP_310252.1	3'-5' exonuclease activity on single or double-strand DNA
YP_310253.1	Code: R; COG: COG0388
YP_310255.1	Code: R; COG: COG2372
YP_310256.1	Code: P; COG: COG1276
YP_310258.1	Code: L; COG: COG0582
YP_310260.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_310261.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_310262.1	Code: L; COG: COG1662
YP_310263.1	Code: L; COG: COG2963
YP_310264.1	Code: L; COG: COG2801
YP_310265.1	Code: S; COG: COG4886
YP_310266.1	Code: L; COG: COG2801
YP_310267.1	Code: L; COG: COG2963
YP_310268.1	Code: L; COG: COG1662
YP_310269.1	Code: L; COG: COG2963
YP_310270.1	Code: L; COG: COG2801
YP_310272.1	Code: L; COG: COG1662
YP_310273.1	in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA
YP_310274.1	Code: R; COG: COG3008
YP_310275.1	Code: S; COG: COG2995
YP_310276.1	Code: T; COG: COG1956
YP_310277.1	affects solute and DNA transport through an unknown mechanism
YP_310278.1	for penicillin-binding protein 3; Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3
YP_310279.1	integral membrane protein; metalloprotease
YP_310280.1	Code: K; COG: COG1414
YP_310283.1	multicopy suppresses mukB mutants, regulator; Code: K; COG: COG1278
YP_310284.1	methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth
YP_310285.1	membrane protein YebN
YP_310286.1	Code: S; COG: COG4811
YP_310287.1	hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel
YP_310288.1	Code: G; COG: COG3715
YP_310289.1	Code: G; COG: COG3444
YP_310290.1	Code: R; COG: COG1253
YP_310291.1	Code: T; COG: COG2200
YP_310292.1	Code: E; COG: COG1760
YP_310293.1	Code: LR; COG: COG0494
YP_310294.1	Code: EH; COG: COG0147
YP_310295.1	Code: S; COG: COG3140
YP_310297.1	Code: L; COG: COG1662
YP_310298.1	Code: J; COG: COG0251
YP_310299.1	Code: KL; COG: COG1199
YP_310300.1	Code: O; COG: COG1214
YP_310301.1	Code: M; COG: COG3065
YP_310302.1	Activates fatty acids by binding to coenzyme A
YP_310303.1	processes tRNA precursor; Code: J; COG: COG0349
YP_310304.1	Code: C; COG: COG1018
YP_310305.1	Code: PR; COG: COG4638
YP_310306.1	member of the betaine, carnitine, choline transporter (BCCT) family; unknown function
YP_310307.1	Code: CE; COG: COG0473
YP_310308.1	Code: K; COG: COG0583
YP_310309.1	Code: E; COG: COG1280
YP_310310.1	Code: P; COG: COG3615
YP_310312.1	Code: S; COG: COG2261
YP_310313.1	Code: T; COG: COG2203
YP_310314.1	Code: R; COG: COG3042
YP_310315.1	Code: S; COG: COG3189
YP_310316.1	Code: P; COG: COG2807
YP_310317.1	Code: K; COG: COG2207
YP_310318.1	Code: S; COG: COG2707
YP_310320.1	Code: S; COG: COG2606
YP_310321.1	Code: T; COG: COG2199
YP_310322.1	Code: L; COG: COG1662
YP_310323.1	Code: T; COG: COG2199
YP_310324.1	Code: S; COG: COG2718
YP_310325.1	Code: T; COG: COG2766
YP_310326.1	Code: M; COG: COG3713
YP_310327.1	Code: R; COG: COG0656
YP_310328.1	Code: G; COG: COG0676
YP_310329.1	Code: L; COG: COG3385
YP_310330.1	Code: G; COG: COG0057
YP_310331.1	this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress
YP_310332.1	Code: S; COG: COG3139
YP_310333.2	catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide
YP_310334.1	converts asparagine to aspartate and ammonia
YP_310335.1	SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane
YP_310336.1	Code: C; COG: COG0778
YP_310337.1	catalyzes the formation of selenophosphate from selenide and ATP
YP_310338.1	decatenates replicating daughter chromosomes
YP_310339.1	Code: L; COG: COG1662
YP_310340.1	converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer
YP_310342.1	Code: LR; COG: COG0494
YP_310343.1	Code: L; COG: COG1662
YP_310344.1	Code: P; COG: COG2897
YP_310345.1	Code: R; COG: COG4136
YP_310346.1	Code: R; COG: COG4134
YP_310347.1	Code: S; COG: COG2128
YP_310348.1	Code: S; COG: COG0398
YP_310350.1	Code: S; COG: COG0398
YP_310351.1	removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction
YP_310352.1	catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate
YP_310353.1	Code: E; COG: COG3138
YP_310354.1	catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation
YP_310355.1	catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism
YP_310356.1	periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP
YP_310357.1	Code: L; COG: COG1662
YP_310358.1	Code: S; COG: COG3758
YP_310359.1	3' incision activity; acts with UvrC
YP_310360.1	prefers NH3 over glutamine; catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers
YP_310361.1	osmotically-inducible lipoprotein E; activator of ntr-like gene protein
YP_310362.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_310363.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_310364.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_310365.1	represses the celABCDF-ydjC operon involved in carbon uptake
YP_310366.1	Code: G; COG: COG1486
YP_310367.1	Code: S; COG: COG3394
YP_310368.1	hydroperoxidase HPII(III); Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide
YP_310370.1	Code: R; COG: COG1823
YP_310371.2	Code: R; COG: COG1988
YP_310372.1	YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate
YP_310374.1	Code: G; COG: COG3001
YP_310376.1	suppressor of pfkA; Code: G; COG: COG1105
YP_310377.1	Code: M; COG: COG3137
YP_310379.1	Code: L; COG: COG1662
YP_310380.1	catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_310381.1	IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits
YP_310382.1	Code: J; COG: COG0291
YP_310383.1	includes regulator; binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit
YP_310385.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily
YP_310386.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily
YP_310387.1	site specific recombination; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
YP_310388.1	with BtuD and BtuF transports vitamin B12 into the cell
YP_310389.1	similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane
YP_310390.1	ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell
YP_310391.1	Code: M; COG: COG0791
YP_310392.1	Code: L; COG: COG3335
YP_310393.1	Code: T; COG: COG2200
YP_310394.1	Code: S; COG: COG0397
YP_310395.1	Code: P; COG: COG4256
YP_310396.1	DAHP synthetase; tryptophan repressible; tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate
YP_310397.1	Code: S; COG: COG1806
YP_310398.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_310399.1	Code: L; COG: COG1662
YP_310400.1	catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis
YP_310401.1	YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate
YP_310402.1	Code: GEPR; COG: COG0477
YP_310403.1	Code: L; COG: COG1662
YP_310405.1	Code: L; COG: COG1662
YP_310406.1	YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function
YP_310407.1	Code: C; COG: COG0277
YP_310408.1	Code: Q; COG: COG2050
YP_310410.1	functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein
YP_310411.1	with SufCD activates cysteine desulfurase SufS
YP_310412.1	part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE
YP_310413.1	with SufBC activates cysteine desulfurase SufS
YP_310414.1	catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine
YP_310415.1	Acts with SufS to catalyze the formation of L-alanine from L-cysteine
YP_310416.1	Code: S; COG: COG1376
YP_310417.1	Code: M; COG: COG4238
YP_310418.1	formerly F; fructose stimulated; catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_310420.1	Code: C; COG: COG0437
YP_310421.1	Code: C; COG: COG2414
YP_310423.1	Code: C; COG: COG0437
YP_310424.1	Code: C; COG: COG4117
YP_310426.1	Code: S; COG: COG4529
YP_310428.1	Code: MU; COG: COG3468
YP_310429.1	NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones
YP_310430.1	catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine
YP_310431.1	catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge
YP_310432.1	uncharacterized member of the major facilitator superfamily (MFS)
YP_310433.1	Code: K; COG: COG0583
YP_310434.1	binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers
YP_310435.1	Code: G; COG: COG2814
YP_310436.1	SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals
YP_310437.1	Code: M; COG: COG0791
YP_310438.1	Code: O; COG: COG0278
YP_310439.1	degrades tRNA; Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A)
YP_310440.1	Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione
YP_310441.1	FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide
YP_310442.1	Code: K; COG: COG1309
YP_310443.1	Code: R; COG: COG3313
YP_310444.1	Code: R; COG: COG4989
YP_310445.1	SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water
YP_310446.1	Code: S; COG: COG1289
YP_310447.1	Code: V; COG: COG1566
YP_310449.2	Transcription regulator that can both activate or repress expression
YP_310450.1	Code: M; COG: COG3133
YP_310451.1	catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling
YP_310452.1	Code: R; COG: COG3895
YP_310453.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate
YP_310454.1	catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr)
YP_310455.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal
YP_310458.1	mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation
YP_310459.1	specific for apurinic and/or apyrimidinic sites; DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines
YP_310460.1	in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase
YP_310461.1	part of membrane-bound complex hought to be involved in electron transport to nitrogen
YP_310462.1	RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents
YP_310463.1	part of membrane-bound complex thought to be involved in electron transport to nitrogen
YP_310464.1	part of membrane-bound complex thought to be involved in electron transport to nitrogen
YP_310465.1	Code: C; COG: COG4657
YP_310467.1	YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes
YP_310468.2	Code: R; COG: COG0673
YP_310469.1	catalyzes the formation of inosine from adenosine
YP_310470.1	Code: E; COG: COG1168
YP_310471.1	phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site
YP_310472.1	regulates malXY which are involved in maltose-glucose transport
YP_310473.1	Code: L; COG: COG2963
YP_310474.1	Code: L; COG: COG2801
YP_310475.1	Acts on the hydroxyl group at position 7 of the steroid frame
YP_310476.1	Code: K; COG: COG1309
YP_310477.1	Code: G; COG: COG3250
YP_310478.1	Code: G; COG: COG2211
YP_310480.1	Code: S; COG: COG5339
YP_310481.1	Code: G; COG: COG1482
YP_310482.1	fumarate hydratase Class I; aerobic isozyme; Code: C; COG: COG1951
YP_310483.1	fumarate hydratase Class II; isozyme; class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle
YP_310484.1	inhibition of replication at Ter sites; binds to DNA replication terminator sequences to prevent passage of replication forks
YP_310485.1	RstA regulator; Code: T; COG: COG0642
YP_310486.1	response regulator in two-component regulatory system with RstB
YP_310487.1	Code: R; COG: COG3136
YP_310488.1	Code: IQR; COG: COG1028
YP_310489.1	Code: E; COG: COG0531
YP_310491.1	forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm
YP_310492.1	catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme
YP_310493.1	transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes
YP_310494.1	with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS
YP_310495.1	with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS
YP_310496.1	Code: E; COG: COG3591
YP_310497.1	required for growth and survival under moderately acid conditions
YP_310498.1	Code: L; COG: COG2801
YP_310499.1	Code: L; COG: COG1484
YP_310500.1	Code: L; COG: COG4584
YP_310502.1	Code: GEPR; COG: COG0477
YP_310503.1	Code: K; COG: COG0583
YP_310504.1	Code: KG; COG: COG1940
YP_310505.2	DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium
YP_310506.2	Code: P; COG: COG0038
YP_310507.2	binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane
YP_310508.1	Code: R; COG: COG3302
YP_310509.1	Code: C; COG: COG0437
YP_310510.1	Code: L; COG: COG1662
YP_310514.1	encoded within cryptic prophage; Code: L; COG: COG1484
YP_310518.1	Code: L; COG: COG1662
YP_310519.1	Code: G; COG: COG0246
YP_310521.1	Code: K; COG: COG1802
YP_310522.1	NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine
YP_310523.1	Code: E; COG: COG0339
YP_310524.1	Code: R; COG: COG1546
YP_310525.1	Code: S; COG: COG3111
YP_310526.1	Code: T; COG: COG2199
YP_310527.1	Code: L; COG: COG1662
YP_310528.1	converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism
YP_310530.2	multiple antibiotic resistance; transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF
YP_310531.2	repressor of mar operon; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
YP_310532.1	protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function
YP_310533.1	Code: G; COG: COG2814
YP_310535.1	Code: K; COG: COG0583
YP_310536.1	in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase
YP_310537.1	catalyzes the formation of glutamate from glutamine
YP_310538.1	Code: L; COG: COG1662
YP_310539.1	Code: T; COG: COG2199
YP_310540.1	catalyzes the formation of D-tagaturonate from D-altronate
YP_310541.1	Code: L; COG: COG1662
YP_310543.1	Code: L; COG: COG3335
YP_310544.1	regulatory protein; Code: K; COG: COG1396
YP_310545.1	Code: L; COG: COG2801
YP_310548.1	Code: L; COG: COG4584
YP_310549.1	Code: L; COG: COG1484
YP_310551.1	similar to FimH protein
YP_310552.1	in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase family
YP_310554.1	regulates the cellular response to acid resistance
YP_310555.1	Code: P; COG: COG3119
YP_310556.1	Code: R; COG: COG0641
YP_310557.1	Code: R; COG: COG4178
YP_310558.1	Code: L; COG: COG3385
YP_310560.1	Code: R; COG: COG0612
YP_310561.1	Code: E; COG: COG0076
YP_310562.1	transporter; Code: E; COG: COG0531
YP_310563.1	Code: S; COG: COG1649
YP_310564.1	Code: T; COG: COG2199
YP_310565.1	heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate
YP_310566.1	catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis
YP_310567.1	Code: E; COG: COG0747
YP_310568.1	Code: EP; COG: COG0601
YP_310569.1	Code: EP; COG: COG1173
YP_310570.1	Code: EP; COG: COG0444
YP_310571.1	Code: EP; COG: COG1124
YP_310572.1	Code: O; COG: COG1764
YP_310573.1	Code: L; COG: COG1662
YP_310574.1	protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase
YP_310575.2	malic enzyme; malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate
YP_310576.1	Code: R; COG: COG3093
YP_310577.1	nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase
YP_310578.1	Code: C; COG: COG0437
YP_310579.1	Code: C; COG: COG0243
YP_310580.1	Code: GER; COG: COG0697
YP_310581.1	Code: M; COG: COG3203
YP_310582.1	Code: S; COG: COG4886
YP_310583.1	Code: L; COG: COG3335
YP_310584.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_310585.1	Code: P; COG: COG2223
YP_310586.1	Code: C; COG: COG5013
YP_310587.1	Code: C; COG: COG1140
YP_310588.1	Code: C; COG: COG2180
YP_310589.1	Code: C; COG: COG2181
YP_310590.1	Code: R; COG: COG0384
YP_310591.1	Code: Q; COG: COG2162
YP_310592.1	Code: R; COG: COG1853
YP_310593.1	4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown
YP_310594.1	Code: L; COG: COG5433
YP_310596.1	Code: L; COG: COG5433
YP_310597.1	Code: L; COG: COG1662
YP_310598.1	Code: L; COG: COG1484
YP_310599.1	Code: L; COG: COG4584
YP_310602.1	Code: M; COG: COG3209
YP_310603.1	conserved protein; receptor; Code: L; COG: COG5433
YP_310604.1	Code: M; COG: COG3209
YP_310606.1	Code: S; COG: COG3501
YP_310608.1	Code: O; COG: COG0625
YP_310609.1	Code: E; COG: COG1113
YP_310610.1	Code: S; COG: COG3391
YP_310611.1	Code: P; COG: COG1629
YP_310612.1	Code: L; COG: COG2963
YP_310613.1	Code: L; COG: COG2801
YP_310615.1	Code: R; COG: COG2130
YP_310616.1	Code: M; COG: COG1247
YP_310617.1	Code: S; COG: COG3238
YP_310620.1	Code: L; COG: COG1662
YP_310621.1	catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation
YP_310622.1	Code: E; COG: COG1177
YP_310623.1	Code: E; COG: COG3842
YP_310624.1	Code: E; COG: COG0687
YP_310625.1	Code: KE; COG: COG1167
YP_310626.1	Code: S; COG: COG1598
YP_310627.1	Code: L; COG: COG2963
YP_310628.1	Code: L; COG: COG2801
YP_310630.1	Code: O; COG: COG0826
YP_310631.1	Code: K; COG: COG1396
YP_310632.1	Code: L; COG: COG2801
YP_310633.1	Code: L; COG: COG1662
YP_310634.1	Code: L; COG: COG2963
YP_310635.1	Code: L; COG: COG0675
YP_310636.1	Code: L; COG: COG1662
YP_310637.1	with TehA confers resistance to tellurite
YP_310638.1	Code: P; COG: COG1275
YP_310640.1	Code: J; COG: COG1670
YP_310641.1	Code: S; COG: COG2841
YP_310643.1	involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans
YP_310644.1	Code: S; COG: COG5383
YP_310645.1	Code: K; COG: COG0583
YP_310646.1	ribose sensor receptor; Code: NT; COG: COG0840
YP_310649.2	B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm
YP_310650.1	Code: G; COG: COG0057
YP_310651.1	Code: L; COG: COG2801
YP_310652.1	Code: L; COG: COG2963
YP_310653.1	Code: L; COG: COG1662
YP_310654.1	Code: L; COG: COG2801
YP_310655.1	Code: L; COG: COG2963
YP_310656.1	Code: S; COG: COG1434
YP_310657.1	involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain
YP_310658.1	FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds
YP_310659.1	Code: I; COG: COG0671
YP_310660.1	Code: QR; COG: COG0500
YP_310661.1	Code: L; COG: COG2801
YP_310662.1	Code: L; COG: COG2963
YP_310663.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_310666.1	Code: CHR; COG: COG1052
YP_310667.1	Code: O; COG: COG3187
YP_310668.1	Code: R; COG: COG3042
YP_310669.1	Code: C; COG: COG0674
YP_310670.1	Code: M; COG: COG3203
YP_310671.1	Code: T; COG: COG0589
YP_310672.1	periplasmic-binding protein; Code: P; COG: COG0803
YP_310673.1	Code: P; COG: COG1121
YP_310674.1	Code: P; COG: COG1108
YP_310675.1	Code: P; COG: COG1108
YP_310677.1	Code: L; COG: COG2801
YP_310678.1	Code: L; COG: COG2963
YP_310679.1	Code: L; COG: COG4584
YP_310680.1	Code: L; COG: COG2963
YP_310681.1	Code: L; COG: COG2801
YP_310683.1	Code: M; COG: COG3637
YP_310684.1	Code: S; COG: COG4733
YP_310685.1	Code: S; COG: COG4723
YP_310686.1	Code: M; COG: COG0791
YP_310687.1	Code: S; COG: COG4672
YP_310688.1	Code: S; COG: COG4718
YP_310690.1	Code: L; COG: COG2963
YP_310691.1	Code: L; COG: COG2963
YP_310696.1	Code: L; COG: COG1662
YP_310700.1	Code: L; COG: COG1662
YP_310701.1	Code: L; COG: COG2963
YP_310702.1	Code: L; COG: COG2801
YP_310703.1	TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs
YP_310704.1	exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA
YP_310705.1	Code: P; COG: COG0598
YP_310706.1	Code: T; COG: COG2199
YP_310707.1	Code: S; COG: COG2840
YP_310708.1	Code: K; COG: COG0583
YP_310709.1	Code: R; COG: COG1473
YP_310710.1	Code: R; COG: COG1473
YP_310711.1	Code: L; COG: COG2963
YP_310712.1	Code: L; COG: COG2801
YP_310713.1	Code: L; COG: COG0350
YP_310714.1	Global transcription factor that controls the expression of over 100 target genes in response to anoxia
YP_310715.1	with UspC and UspD is involved in resistance to UV irradiation
YP_310717.1	Code: L; COG: COG1662
YP_310718.1	Code: E; COG: COG4166
YP_310719.1	Code: K; COG: COG0583
YP_310720.1	Code: R; COG: COG1073
YP_310721.1	Code: R; COG: COG1073
YP_310722.1	Code: L; COG: COG1662
YP_310723.1	Code: R; COG: COG1073
YP_310724.1	Code: MG; COG: COG0702
YP_310725.1	Code: L; COG: COG1662
YP_310726.1	Code: E; COG: COG2866
YP_310727.1	Code: MR; COG: COG4948
YP_310728.1	antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein
YP_310729.1	regulates genes involved in the biosynthesis and transport of aromatic amino acids
YP_310730.1	Code: L; COG: COG1662
YP_310731.1	Code: S; COG: COG3768
YP_310732.1	Code: R; COG: COG3106
YP_310733.1	Code: K; COG: COG1609
YP_310734.1	Code: L; COG: COG1662
YP_310735.1	Code: R; COG: COG0637
YP_310736.1	Code: G; COG: COG1554
YP_310737.1	Code: R; COG: COG0673
YP_310738.1	Code: G; COG: COG1082
YP_310739.1	Code: ER; COG: COG1063
YP_310740.1	Code: G; COG: COG1175
YP_310741.1	Code: G; COG: COG1653
YP_310742.1	rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide
YP_310744.1	activates phage shock-protein expression; with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock
YP_310745.1	acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding
YP_310746.1	inner membrane protein; involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF
YP_310747.2	transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor
YP_310748.1	Code: E; COG: COG0665
YP_310749.1	prefers NADP over NAD; Code: C; COG: COG1012
YP_310750.1	regulates genes involved in putrescine degradation
YP_310751.1	catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate
YP_310752.1	Code: E; COG: COG0174
YP_310753.1	Code: E; COG: COG0531
YP_310755.1	similar to Salmonella peptide transport periplasmic protein; Code: E; COG: COG4166
YP_310756.1	similar to Salmonella peptide transport periplasmic protein; Code: V; COG: COG4168
YP_310757.1	similar to Salmonella peptide transport periplasmic protein; Code: V; COG: COG4171
YP_310758.1	Code: V; COG: COG4170
YP_310759.1	Code: V; COG: COG4167
YP_310760.1	Code: S; COG: COG2852
YP_310761.1	Catalyzes a key regulatory step in fatty acid biosynthesis
YP_310762.1	mRNA degradation; Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
YP_310763.1	Code: KG; COG: COG1349
YP_310765.1	involved in start site selection during the initiation of translation
YP_310766.1	type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase
YP_310767.1	Code: G; COG: COG2956
YP_310768.1	Code: S; COG: COG3771
YP_310769.1	Code: I; COG: COG0671
YP_310770.1	catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate
YP_310771.1	Catalyzes the conversion of citrate to isocitrate
YP_310774.1	Code: L; COG: COG1662
YP_310775.1	LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation
YP_310776.1	omega protein; catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity
YP_310778.1	SohB; periplasmic protein; member of the peptidase S49 family
YP_310779.1	Code: IQR; COG: COG1028
YP_310780.1	catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide
YP_310781.1	catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA
YP_310782.1	Code: J; COG: COG0009
YP_310783.1	Code: R; COG: COG0613
YP_310785.1	with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine
YP_310786.1	glutamine amidotransferase and phosphoribosylanthranilate transferase; bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis
YP_310787.1	indole-3-glycerolphosphate synthetase; monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate
YP_310788.1	catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate
YP_310789.1	catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis
YP_310790.1	Code: L; COG: COG1662
YP_310792.1	Code: QR; COG: COG0500
YP_310796.1	Code: L; COG: COG2963
YP_310797.1	Code: L; COG: COG2801
YP_310799.1	Code: L; COG: COG2801
YP_310800.1	Code: L; COG: COG2963
YP_310801.1	Code: L; COG: COG2801
YP_310802.1	Code: L; COG: COG0863
YP_310804.1	similar to cryptic prophage protein
YP_310805.1	Code: L; COG: COG4570
YP_310809.1	Code: L; COG: COG2801
YP_310810.1	Code: L; COG: COG2963
YP_310811.1	Code: L; COG: COG1662
YP_310813.1	receptor for colicin S4
YP_310815.1	Involved in cell division; probably involved in intracellular septation
YP_310816.1	YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins
YP_310817.1	energy transducer; uptake of iron, cyanocobalimin; sensitivity to phages, colicins; membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins
YP_310819.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_310821.1	Code: L; COG: COG2801
YP_310822.1	Code: L; COG: COG2963
YP_310823.1	Code: L; COG: COG3335
YP_310827.1	Code: L; COG: COG1662
YP_310829.1	Code: L; COG: COG1961
YP_310830.2	unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity
YP_310831.1	Code: L; COG: COG2801
YP_310832.1	Code: L; COG: COG2963
YP_310833.1	Code: P; COG: COG1226
YP_310834.1	catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol)
YP_310835.2	highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein
YP_310836.1	Code: E; COG: COG4608
YP_310837.1	Code: EP; COG: COG0444
YP_310838.1	similar to Salmonella oligopeptide transport permease protein; Code: EP; COG: COG1173
YP_310839.1	Code: EP; COG: COG0601
YP_310840.1	Code: E; COG: COG4166
YP_310841.1	Code: U; COG: COG2095
YP_310842.1	Code: C; COG: COG1454
YP_310843.1	Code: L; COG: COG3385
YP_310844.1	catalyzes the formation of thymidine 5'-phosphate from thymidine
YP_310845.1	HU, BH2, HD, NS; pleiotropic regulator; Code: R; COG: COG2916
YP_310846.1	together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose
YP_310847.1	Code: T; COG: COG0784
YP_310848.1	Code: R; COG: COG1752
YP_310849.1	Code: S; COG: COG3012
YP_310850.1	produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine
YP_310851.1	Code: C; COG: COG2181
YP_310852.1	Code: C; COG: COG2180
YP_310853.1	Code: C; COG: COG1140
YP_310854.1	Code: C; COG: COG5013
YP_310855.1	Code: P; COG: COG2223
YP_310857.1	Code: T; COG: COG3850
YP_310858.1	two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase
YP_310860.1	Code: P; COG: COG1553
YP_310861.1	Code: P; COG: COG3703
YP_310862.1	in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions
YP_310863.1	Code: P; COG: COG0387
YP_310865.1	catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis
YP_310866.1	Code: S; COG: COG3094
YP_310867.1	HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB
YP_310868.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_310869.1	catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins
YP_310870.1	an enzyme in main pathway of synthesis of 5-aminolevulinate, possibly glutamyl-tRNA dehydrogenase; Incorporates lipoproteins in the outer membrane after they are released by the LolA protein
YP_310871.1	An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis
YP_310872.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_310873.1	role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport
YP_310874.1	YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function
YP_310875.1	Enables the recycling of peptidyl-tRNAs produced at termination of translation
YP_310876.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_310878.1	Code: L; COG: COG1662
YP_310879.1	Code: L; COG: COG2801
YP_310880.1	Code: L; COG: COG2963
YP_310882.1	has RflA activity; flagellin specific chaperone
YP_310883.1	has RflA activity; binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family
YP_310884.1	converts 1,4-alpha-D-glucans to maltodextrin
YP_310886.1	Code: R; COG: COG2391
YP_310887.1	Code: O; COG: COG0425
YP_310888.1	Code: S; COG: COG2135
YP_310889.1	Code: L; COG: COG0675
YP_310890.1	Code: L; COG: COG1662
YP_310891.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_310892.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_310893.1	Code: K; COG: COG2207
YP_310894.1	DLP12 prophage; similar to PEBP/RK1P protein family in eukaryotes that inhibits MEK phosphorylation by Raf-1; crystal structure suggests similar properties but exact function is unknown
YP_310895.1	member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation
YP_310896.1	possibly at (MS-ring)-rod junction; forms a junction between the M-ring and FlgB during flagella biosynthesis
YP_310897.1	the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod
YP_310898.1	flagellar biosynthesis; component of motor switching and energizing; enabling rotation and determining its direction; One of three proteins involved in switching the direction of the flagellar rotation
YP_310899.2	possibly involved in export of flagellar proteins; binds to and inhibits the function of flagella specific ATPase FliI
YP_310900.1	involved in type III protein export during flagellum assembly
YP_310901.1	rod/hook and filament chaperone
YP_310902.1	Code: N; COG: COG3144
YP_310903.1	interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring
YP_310904.1	with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation
YP_310905.1	flagellar biosynthesis, component of motor switch and energizing, enabling rotation and determining its direction; One of three proteins involved in switching the direction of the flagellar rotation
YP_310906.1	with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus
YP_310907.1	FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus
YP_310908.1	with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus
YP_310909.1	FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus
YP_310910.1	positive transcription factor; Code: K; COG: COG2771
YP_310913.1	catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate
YP_310914.1	Code: T; COG: COG2199
YP_310915.1	Code: S; COG: COG5475
YP_310916.1	Code: S; COG: COG2354
YP_310917.1	patch repair protein; Code: L; COG: COG3727
YP_310918.1	Code: L; COG: COG0270
YP_310919.1	Code: R; COG: COG1418
YP_310921.1	Code: L; COG: COG1662
YP_310922.1	Hsp31 stabilizes early unfolding protein intermediates under severe heat stress
YP_310923.1	Code: L; COG: COG2963
YP_310924.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_310925.1	Code: T; COG: COG0642
YP_310926.2	induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced
YP_310927.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_310928.1	Code: R; COG: COG2351
YP_310929.1	in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ
YP_310930.1	in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme
YP_310931.1	Code: R; COG: COG3443
YP_310932.1	Code: S; COG: COG3228
YP_310933.1	Code: L; COG: COG2801
YP_310934.1	Code: L; COG: COG3335
YP_310935.1	Code: M; COG: COG0859
YP_310936.1	Code: L; COG: COG1662
YP_310937.1	LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB
YP_310938.1	Code: V; COG: COG0534
YP_310939.1	Code: S; COG: COG0217
YP_310940.1	Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile
YP_310941.1	Code: L; COG: COG1662
YP_310942.1	Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation
YP_310943.1	catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole
YP_310944.1	catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole
YP_310945.1	catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP
YP_310947.1	Code: TK; COG: COG4936
YP_310948.1	Code: G; COG: COG0580
YP_310949.1	Code: QC; COG: COG4577
YP_310950.1	Code: E; COG: COG4816
YP_310951.1	Code: Q; COG: COG4909
YP_310953.1	Code: Q; COG: COG4910
YP_310956.1	Code: QC; COG: COG4577
YP_310957.1	Code: QC; COG: COG4577
YP_310958.1	Code: Q; COG: COG4869
YP_310960.1	Code: QC; COG: COG4576
YP_310961.1	Code: S; COG: COG2096
YP_310962.1	Code: C; COG: COG1012
YP_310963.1	Code: C; COG: COG1454
YP_310964.1	Code: C; COG: COG4656
YP_310965.1	Code: QC; COG: COG4577
YP_310966.1	Code: E; COG: COG4810
YP_310967.1	Code: E; COG: COG4917
YP_310968.1	Code: S; COG: COG2926
YP_310969.1	Code: S; COG: COG1289
YP_310970.1	Code: L; COG: COG3449
YP_310971.1	removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains
YP_310972.1	exonuclease I, 3' --> 5' specific; Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
YP_310973.1	Code: O; COG: COG0425
YP_310974.1	Code: R; COG: COG2391
YP_310975.1	Code: E; COG: COG0531
YP_310976.1	Code: K; COG: COG0583
YP_310977.1	Code: MG; COG: COG0451
YP_310978.1	Code: S; COG: COG4115
YP_310979.1	Antitoxin that counteracts the effect of the YoeB toxin
YP_310981.1	long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors
YP_310982.1	L-histidinol:NAD+ oxidoreductase; catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer
YP_310983.1	catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis
YP_310984.2	catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate
YP_310985.1	imidazole glycerol phosphate synthase holoenzyme; with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide
YP_310986.2	catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide
YP_310987.1	imidazole glycerol phsphate synthase holoenzyme; catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase
YP_310988.1	catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis
YP_310989.1	Code: M; COG: COG3765
YP_310990.1	Code: M; COG: COG1004
YP_310991.1	catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate
YP_310992.1	Code: G; COG: COG1109
YP_310993.1	Code: M; COG: COG0836
YP_310994.1	Code: M; COG: COG0438
YP_310995.1	Code: LR; COG: COG0494
YP_310996.1	Code: MG; COG: COG0451
YP_310997.1	Code: M; COG: COG1089
YP_310998.1	acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit)
YP_310999.1	Code: M; COG: COG0463
YP_311000.1	essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance
YP_311001.1	Code: M; COG: COG0438
YP_311002.1	acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium
YP_311003.1	Code: M; COG: COG0463
YP_311004.2	Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide)
YP_311005.1	Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis
YP_311006.1	Code: M; COG: COG1596
YP_311007.1	Code: R; COG: COG1253
YP_311008.1	YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs
YP_311009.1	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis
YP_311010.2	functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor
YP_311011.1	contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction
YP_311012.1	inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine
YP_311013.2	Code: O; COG: COG0443
YP_311014.1	Code: R; COG: COG4248
YP_311016.1	Code: R; COG: COG4245
YP_311017.2	Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate
YP_311018.1	Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate
YP_311019.1	Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate
YP_311020.1	Code: GEPR; COG: COG0477
YP_311021.1	Code: T; COG: COG0642
YP_311022.1	sensor BaeS; response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport
YP_311023.1	Code: L; COG: COG1662
YP_311024.1	Code: S; COG: COG3422
YP_311025.1	Code: O; COG: COG0826
YP_311027.1	cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role
YP_311028.1	Code: KG; COG: COG1349
YP_311029.1	Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate
YP_311030.1	Code: G; COG: COG3775
YP_311031.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_311032.1	Code: L; COG: COG1662
YP_311033.2	catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway
YP_311034.2	catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate
YP_311035.1	Code: GEPR; COG: COG0477
YP_311036.1	Code: O; COG: COG1397
YP_311037.1	Code: G; COG: COG0524
YP_311038.1	Code: K; COG: COG2188
YP_311039.1	Code: M; COG: COG3757
YP_311040.1	catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine
YP_311041.1	catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP
YP_311042.1	Code: S; COG: COG1937
YP_311043.1	membrane protein conferring nickel and cobalt resistance
YP_311044.1	Code: S; COG: COG5455
YP_311046.1	Code: L; COG: COG1662
YP_311047.1	Code: NU; COG: COG3121
YP_311048.1	Code: NU; COG: COG3539
YP_311050.2	Code: D; COG: COG0489
YP_311051.1	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content
YP_311052.1	Code: S; COG: COG3831
YP_311053.1	Code: L; COG: COG1662
YP_311054.1	Code: L; COG: COG2801
YP_311055.1	Code: S; COG: COG4808
YP_311056.1	Code: S; COG: COG4807
YP_311057.1	unknown function; when overproduced it confers drug-resistance
YP_311058.1	Code: T; COG: COG3275
YP_311060.1	Code: L; COG: COG1662
YP_311062.1	Code: L; COG: COG3547
YP_311064.1	Code: QR; COG: COG0500
YP_311065.1	Code: S; COG: COG4886
YP_311067.1	Code: L; COG: COG2963
YP_311068.1	Code: L; COG: COG0582
YP_311069.1	Code: K; COG: COG0789
YP_311071.1	Code: E; COG: COG1174
YP_311072.1	Code: E; COG: COG1125
YP_311073.1	Code: E; COG: COG1174
YP_311074.1	Code: M; COG: COG1732
YP_311075.1	Code: G; COG: COG1472
YP_311076.1	FAD protein; NADH independent; component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent
YP_311077.1	specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7
YP_311079.1	Code: S; COG: COG0586
YP_311080.1	Code: IQR; COG: COG1028
YP_311081.2	may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
YP_311082.1	Code: J; COG: COG0042
YP_311083.1	Code: R; COG: COG1380
YP_311084.1	Code: M; COG: COG1346
YP_311085.1	Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis
YP_311086.1	Code: S; COG: COG2949
YP_311088.2	catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines
YP_311089.1	ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex
YP_311090.1	with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains
YP_311091.1	receptor for galactose taxis; Code: G; COG: COG1879
YP_311092.1	galactose operon inducer; negative regulator of the mglBAC operon for galactose utilization
YP_311093.1	Code: S; COG: COG2311
YP_311094.1	involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer
YP_311095.1	Code: R; COG: COG0627
YP_311096.1	porin; requires tonB gene product; Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein
YP_311097.1	Code: E; COG: COG0833
YP_311098.1	Code: K; COG: COG0583
YP_311099.1	Code: S; COG: COG2855
YP_311100.1	Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues
YP_311101.1	Code: G; COG: COG0524
YP_311102.1	Code: F; COG: COG1972
YP_311103.1	Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively
YP_311104.1	activator of nucleoside metabolism
YP_311105.1	Code: F; COG: COG1972
YP_311106.1	Code: Q; COG: COG2313
YP_311107.1	Code: G; COG: COG0524
YP_311108.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_311109.1	converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers
YP_311110.1	phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr
YP_311111.1	Code: GEPR; COG: COG0477
YP_311112.2	Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein
YP_311113.1	Code: G; COG: COG0246
YP_311114.1	Code: R; COG: COG0523
YP_311115.1	Code: I; COG: COG0671
YP_311116.1	by similarity, Spr seems to have peptidase activity; involved in thermoresistance
YP_311117.1	Code: T; COG: COG2200
YP_311118.1	Code: E; COG: COG4166
YP_311119.1	Code: R; COG: COG4174
YP_311120.1	Code: R; COG: COG4239
YP_311121.1	Code: R; COG: COG4172
YP_311123.1	catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA
YP_311124.1	Code: KL; COG: COG1061
YP_311125.1	the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response
YP_311126.1	Code: R; COG: COG3081
YP_311127.1	Code: S; COG: COG3082
YP_311128.1	Code: R; COG: COG3083
YP_311129.1	Code: L; COG: COG2801
YP_311130.1	Code: L; COG: COG4584
YP_311131.1	Code: L; COG: COG1484
YP_311133.1	sensor NarQ; nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes
YP_311134.1	Code: O; COG: COG4235
YP_311135.1	possibly involved in biogenesis of cytochrome c; Code: OC; COG: COG0526
YP_311136.1	Code: O; COG: COG1138
YP_311137.1	CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane
YP_311138.1	Code: U; COG: COG3114
YP_311139.1	Code: O; COG: COG0755
YP_311140.1	Code: O; COG: COG2386
YP_311141.1	ATP-binding protein; required for proper cytochrome c maturation
YP_311142.1	with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone
YP_311143.2	small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA
YP_311144.1	part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA
YP_311145.1	part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway
YP_311146.1	periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC
YP_311147.1	Code: P; COG: COG3062
YP_311148.1	Predicted role in electron transfer to the periplasmic nitrate reductase protein NapA.
YP_311149.1	a serine protease inhibitor; serine protease inhibitor, inhibits trypsin and other proteases
YP_311150.1	malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate
YP_311151.1	efflux pump for the antibacterial peptide microcin J25
YP_311152.1	Code: L; COG: COG3145
YP_311153.1	transcription activator/repressor; Code: F; COG: COG2169
YP_311154.1	catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway
YP_311155.1	allows for ions and hydrophilic solutes to cross the outer membrane
YP_311156.1	Code: L; COG: COG1662
YP_311157.1	Code: T; COG: COG0642
YP_311158.1	sensor RcsC; two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF
YP_311159.2	probable histidine kinase acting on RcsB; Code: T; COG: COG0642
YP_311160.1	with AtoC is a member of a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism
YP_311161.1	sensor ATOS; ornithine decarboxylase antizyme; with AtoS is a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism
YP_311162.1	Code: I; COG: COG1788
YP_311163.1	Code: I; COG: COG2057
YP_311164.1	Code: I; COG: COG2031
YP_311165.1	Code: I; COG: COG0183
YP_311166.1	Code: S; COG: COG4676
YP_311167.1	Code: S; COG: COG5445
YP_311168.1	Code: L; COG: COG1662
YP_311169.1	Code: S; COG: COG4685
YP_311170.1	type II topoisomerase; negatively supercoils closed circular double-stranded DNA
YP_311171.1	Involved in ubiquinone biosynthesis
YP_311172.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_311173.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_311174.1	B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA
YP_311175.1	plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases
YP_311176.1	involved in stress response
YP_311177.1	Code: L; COG: COG2801
YP_311178.1	Code: L; COG: COG2801
YP_311179.1	Code: L; COG: COG2963
YP_311180.1	hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic
YP_311181.1	catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell
YP_311182.1	anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor
YP_311183.1	sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters
YP_311184.1	anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate
YP_311185.1	Code: S; COG: COG5464
YP_311186.1	Code: G; COG: COG3836
YP_311187.1	Code: GEPR; COG: COG0477
YP_311188.1	Code: MR; COG: COG4948
YP_311189.1	Code: K; COG: COG1414
YP_311190.1	Code: R; COG: COG1058
YP_311192.1	Code: LR; COG: COG0494
YP_311194.2	catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose
YP_311195.1	catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate
YP_311196.1	Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains
YP_311197.1	Code: G; COG: COG0726
YP_311198.1	catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A
YP_311199.2	Code: GER; COG: COG0697
YP_311201.1	Code: IQ; COG: COG0318
YP_311202.1	catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate
YP_311203.1	catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA
YP_311204.1	catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA
YP_311205.1	SHCHC synthase; SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis
YP_311206.2	menaquinone biosynthesis; Code: HQ; COG: COG1169
YP_311207.1	Code: S; COG: COG4575
YP_311208.1	Code: R; COG: COG2153
YP_311209.2	member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions
YP_311210.1	Code: L; COG: COG1662
YP_311211.1	Code: L; COG: COG1662
YP_311213.2	Catalyzes the transfer of electrons from NADH to quinone
YP_311214.1	Catalyzes the transfer of electrons from NADH to quinone
YP_311215.1	Catalyzes the transfer of electrons from NADH to ubiquinone
YP_311216.1	Catalyzes the transfer of electrons from NADH to quinone
YP_311217.1	Catalyzes the transfer of electrons from NADH to quinone
YP_311218.1	Catalyzes the transfer of electrons from NADH to quinone
YP_311219.1	Catalyzes the transfer of electrons from NADH to quinone
YP_311220.1	Catalyzes the transfer of electrons from NADH to quinone
YP_311221.1	shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase
YP_311222.1	Catalyzes the transfer of electrons from NADH to quinone
YP_311223.1	NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms
YP_311224.1	The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen
YP_311225.1	Catalyzes the transfer of electrons from NADH to quinone
YP_311226.1	Code: K; COG: COG0583
YP_311227.1	broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor
YP_311228.1	Code: R; COG: COG1896
YP_311229.1	Code: P; COG: COG0471
YP_311230.2	Code: S; COG: COG3013
YP_311231.1	Code: S; COG: COG3092
YP_311232.1	AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA
YP_311233.1	catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate
YP_311234.2	Code: S; COG: COG1288
YP_311235.1	Code: LR; COG: COG0494
YP_311236.1	Code: R; COG: COG0622
YP_311237.1	Code: O; COG: COG0625
YP_311238.1	Code: O; COG: COG0625
YP_311239.1	catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate
YP_311240.1	Code: R; COG: COG1090
YP_311241.1	Code: L; COG: COG1662
YP_311242.1	Code: E; COG: COG4598
YP_311243.1	Code: E; COG: COG4160
YP_311244.1	Code: E; COG: COG4215
YP_311245.1	Code: ET; COG: COG0834
YP_311246.1	Code: ET; COG: COG0834
YP_311247.1	catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate
YP_311248.1	PRPP amidotransferase; Catalyzes first step of the de novo purine nucleotide biosynthetic pathway
YP_311249.1	membrane protein required for colicin V production
YP_311250.2	Code: S; COG: COG3147
YP_311251.1	dihydrofolate synthetase; Code: H; COG: COG0285
YP_311252.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits
YP_311253.1	Code: S; COG: COG0586
YP_311254.1	mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability
YP_311255.1	Code: E; COG: COG0136
YP_311256.1	Code: HE; COG: COG0111
YP_311257.1	in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein
YP_311258.1	Code: GEPR; COG: COG0477
YP_311259.1	FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_311260.2	catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules
YP_311262.1	Code: S; COG: COG3101
YP_311263.1	Code: R; COG: COG0730
YP_311264.1	D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm
YP_311265.1	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
YP_311266.1	involved in methylation of ribosomal protein L3
YP_311267.1	Code: S; COG: COG2840
YP_311269.1	Code: NU; COG: COG3539
YP_311270.1	Code: NU; COG: COG3539
YP_311271.1	Code: NU; COG: COG3121
YP_311272.1	involved in fimbrial biogenesis; Code: NU; COG: COG3188
YP_311273.1	Code: NU; COG: COG3539
YP_311274.1	Code: T; COG: COG2062
YP_311275.1	multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate
YP_311276.1	FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth
YP_311277.1	Code: S; COG: COG3691
YP_311278.1	Code: I; COG: COG2067
YP_311279.1	Code: L; COG: COG3547
YP_311280.1	Code: L; COG: COG1662
YP_311281.1	Code: M; COG: COG2853
YP_311282.1	Code: P; COG: COG2116
YP_311283.1	Code: L; COG: COG0582
YP_311284.1	Code: L; COG: COG2801
YP_311285.1	Code: L; COG: COG1662
YP_311287.1	Code: M; COG: COG3637
YP_311288.1	Code: S; COG: COG4733
YP_311289.1	Code: S; COG: COG4723
YP_311290.1	Code: M; COG: COG0791
YP_311291.1	Code: S; COG: COG4672
YP_311292.1	Code: S; COG: COG4718
YP_311293.1	Code: S; COG: COG5281
YP_311296.1	Code: N; COG: COG5492
YP_311303.1	Code: OU; COG: COG0616
YP_311304.1	Code: R; COG: COG5511
YP_311306.1	Code: R; COG: COG5525
YP_311307.1	Code: L; COG: COG4220
YP_311308.1	Code: R; COG: COG5562
YP_311309.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_311310.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_311313.1	Code: R; COG: COG3772
YP_311315.1	Code: L; COG: COG1662
YP_311316.1	Code: M; COG: COG3203
YP_311319.1	Holliday junction resolvase; DLP12 prophage; Holliday junction resolvase
YP_311321.1	similar to phage 82 and lambda proteins; DLP12 prophage; conserved protein similar to phage 82 and lambda proteins
YP_311322.1	DLP12 prophage
YP_311323.1	Code: L; COG: COG4584
YP_311324.1	Code: L; COG: COG1484
YP_311325.1	Code: L; COG: COG1662
YP_311326.1	lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments
YP_311327.1	Code: L; COG: COG1662
YP_311328.1	Code: L; COG: COG2801
YP_311329.1	Code: L; COG: COG3385
YP_311330.1	Code: G; COG: COG1621
YP_311331.1	Code: K; COG: COG1609
YP_311333.1	deaminase; catalyzes the formation of pyruvate from serine
YP_311334.1	Code: GEPR; COG: COG0477
YP_311335.1	Code: V; COG: COG1566
YP_311336.1	response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance
YP_311337.1	Code: ET; COG: COG0834
YP_311338.1	Code: C; COG: COG1804
YP_311339.1	member of the AEC family of auxin efflux transporters; unknown function
YP_311340.1	catalyzes the formation of formyl-CoA from oxalyl-CoA
YP_311341.1	catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA
YP_311345.2	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock
YP_311346.1	Code: E; COG: COG0436
YP_311347.1	Code: L; COG: COG1662
YP_311348.1	Code: KT; COG: COG3279
YP_311349.1	Code: K; COG: COG2207
YP_311350.1	metalloprotein
YP_311351.1	Code: G; COG: COG1299
YP_311352.1	Code: G; COG: COG1445
YP_311353.1	catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate
YP_311354.1	Code: P; COG: COG0038
YP_311357.1	Code: P; COG: COG1914
YP_311358.1	Code: F; COG: COG1972
YP_311361.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_311363.1	Code: K; COG: COG0583
YP_311364.1	Code: R; COG: COG0385
YP_311365.1	Code: S; COG: COG3530
YP_311366.1	this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB
YP_311367.1	involved in FtsZ ring; interacts with cell division protein FitsZ and may be required to anchor septal ring structure
YP_311368.1	required for sulfate transport; role in sulfur assimilation
YP_311369.1	O-acetylserine sulfhydrolase A; CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis
YP_311370.1	Code: G; COG: COG1925
YP_311371.1	Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system
YP_311372.1	functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose
YP_311373.1	Code: L; COG: COG3385
YP_311374.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal
YP_311376.1	O-acetylserine sulfhydrolase B; catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide
YP_311377.1	chromate resistance; Code: P; COG: COG1118
YP_311378.1	Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import
YP_311379.1	Code: O; COG: COG0555
YP_311380.1	Code: P; COG: COG4150
YP_311381.2	Code: IQR; COG: COG1028
YP_311382.1	Code: K; COG: COG1737
YP_311383.1	catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway
YP_311384.2	Code: V; COG: COG1680
YP_311385.1	Code: P; COG: COG2837
YP_311388.2	Code: R; COG: COG0456
YP_311389.1	Code: M; COG: COG0860
YP_311390.1	catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis
YP_311391.1	activates the transcription of the ethanolamine utilization operon
YP_311392.1	Code: QC; COG: COG4577
YP_311393.1	Code: E; COG: COG4816
YP_311394.1	catalyzes the formation of acetaldehyde from ethanolamine
YP_311395.1	ethanolamine utilization protein EutA
YP_311396.1	ethanolamine utilization; similar to Salmonella transport protein; Code: E; COG: COG3192
YP_311397.1	ethanolamine utilization; similar to Salmonella enzyme, similar to iron-containing alcohol dehydrogenase; Code: C; COG: COG1454
YP_311398.1	ethanolamine utilization; similar to Salmonella protein; Code: E; COG: COG4820
YP_311399.1	ethanolamine utilization; similar to acetaldehyde dehydrogenase; Code: C; COG: COG1012
YP_311400.1	Code: QC; COG: COG4576
YP_311401.2	Code: QC; COG: COG4577
YP_311402.1	ethanolamine utilization; similar to Salmonella acetyl/butyryl P transferase; in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta
YP_311403.1	Code: E; COG: COG4812
YP_311404.1	Code: E; COG: COG4766
YP_311405.1	Code: E; COG: COG4917
YP_311406.1	Code: E; COG: COG4810
YP_311407.1	NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate
YP_311408.1	Code: G; COG: COG0176
YP_311409.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_311411.1	Code: LR; COG: COG0494
YP_311412.1	unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic)
YP_311413.1	Code: T; COG: COG3850
YP_311414.1	sensitivity to acriflavine; integral membrane protein; possible efflux pump; Code: V; COG: COG0841
YP_311415.1	Code: P; COG: COG1393
YP_311416.1	dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.
YP_311418.2	Displays esterase activity toward palmitoyl-CoA and pNP-butyrate
YP_311419.1	Code: R; COG: COG1444
YP_311420.1	Code: R; COG: COG2321
YP_311421.1	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_311422.1	Code: M; COG: COG3317
YP_311423.1	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_311424.2	negative transcriptional regulator of the gcvTHP operon
YP_311425.1	bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine
YP_311426.1	Code: C; COG: COG1142
YP_311427.1	Code: CP; COG: COG0651
YP_311428.1	Code: C; COG: COG0650
YP_311429.1	Code: CP; COG: COG1009
YP_311430.1	interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide
YP_311431.1	Code: CP; COG: COG0651
YP_311432.1	Code: C; COG: COG3261
YP_311433.1	probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far
YP_311434.1	Code: C; COG: COG3260
YP_311436.1	Code: KT; COG: COG3604
YP_311437.1	Code: L; COG: COG3547
YP_311438.1	Code: R; COG: COG0628
YP_311439.1	Code: R; COG: COG4783
YP_311440.1	Code: P; COG: COG1393
YP_311441.1	controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP
YP_311442.1	Code: F; COG: COG2233
YP_311443.2	Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate
YP_311444.1	AIR synthetase; catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
YP_311445.1	glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate
YP_311446.1	catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate
YP_311447.1	Code: FP; COG: COG0248
YP_311448.1	Code: T; COG: COG2200
YP_311452.1	glutamine-hydrolyzing; contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
YP_311453.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_311454.1	bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides
YP_311456.2	EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains
YP_311457.1	with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis
YP_311458.1	Code: S; COG: COG2976
YP_311459.1	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG
YP_311460.1	catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis
YP_311461.1	Code: S; COG: COG1426
YP_311462.1	23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance
YP_311463.1	catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate
YP_311464.1	penicillin-insensitive transglycosylase/transpeptidase
YP_311465.1	Code: R; COG: COG2373
YP_311466.2	catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds
YP_311467.2	enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I
YP_311468.2	catalyzes the removal of an N-terminal amino acid from a peptide or arylamide
YP_311469.1	Code: S; COG: COG2975
YP_311470.1	Code: C; COG: COG0633
YP_311471.1	chaperone; member of Hsp70 protein family; involved in the maturation of iron-sulfur cluster-containing proteins
YP_311472.1	J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins
YP_311473.1	forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein
YP_311474.1	Code: C; COG: COG0822
YP_311475.1	catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis
YP_311476.1	regulates the expression of the iscRSUA operon
YP_311477.1	Code: J; COG: COG0565
YP_311478.1	enhances synthesis of sigma32 in mutant; extragenic suppressor, may modulate RNAse III lethal action; Code: G; COG: COG0483
YP_311479.1	Code: R; COG: COG1073
YP_311480.2	Code: K; COG: COG3711
YP_311481.1	transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters
YP_311482.1	Code: PR; COG: COG4638
YP_311483.1	Code: Q; COG: COG5517
YP_311484.1	Code: PR; COG: COG2146
YP_311485.1	Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate
YP_311486.1	Code: R; COG: COG0446
YP_311487.1	Code: L; COG: COG1662
YP_311488.1	Code: G; COG: COG2017
YP_311489.1	Code: ER; COG: COG1063
YP_311490.1	Code: G; COG: COG1172
YP_311491.1	Code: G; COG: COG1129
YP_311492.1	Code: G; COG: COG1879
YP_311493.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_311494.1	flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine
YP_311495.1	indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA
YP_311496.1	Code: T; COG: COG2204
YP_311498.1	Code: T; COG: COG0642
YP_311499.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_311500.1	YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function
YP_311501.1	Code: FJ; COG: COG0590
YP_311502.2	Code: E; COG: COG0560
YP_311503.2	Code: K; COG: COG1737
YP_311504.1	Code: S; COG: COG4886
YP_311508.1	Code: L; COG: COG3436
YP_311509.1	Code: L; COG: COG2801
YP_311510.1	Code: L; COG: COG2963
YP_311511.1	Code: L; COG: COG3547
YP_311512.1	Code: L; COG: COG2801
YP_311513.1	Code: L; COG: COG2963
YP_311518.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_311520.1	Code: S; COG: COG3016
YP_311521.1	TonB-like; Code: M; COG: COG0810
YP_311522.1	Code: P; COG: COG1629
YP_311524.1	Code: L; COG: COG3436
YP_311525.1	Code: L; COG: COG3436
YP_311526.1	Code: L; COG: COG1662
YP_311527.1	Code: L; COG: COG3547
YP_311528.1	Code: L; COG: COG2963
YP_311529.1	Code: L; COG: COG2801
YP_311533.1	Code: U; COG: COG3451
YP_311536.1	Code: L; COG: COG2801
YP_311537.1	Code: L; COG: COG2963
YP_311538.1	Code: L; COG: COG1484
YP_311539.1	Code: L; COG: COG4584
YP_311543.1	Code: C; COG: COG1145
YP_311544.1	Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids
YP_311545.1	involved in the de novo synthesis of pyridoxine (Vitamin B6)
YP_311546.1	involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA
YP_311547.1	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome
YP_311548.1	ds RNA; cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity
YP_311549.1	catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins
YP_311550.1	may be inner membrane protein; binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_311551.1	negative regulatory protein; involved in the reduction of the SoxR iron-sulfur cluster
YP_311552.1	periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP
YP_311553.1	Code: T; COG: COG3073
YP_311554.1	heat shock and oxidative stress; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response
YP_311555.1	Code: L; COG: COG2963
YP_311556.1	Code: L; COG: COG2801
YP_311557.1	Code: R; COG: COG4123
YP_311558.1	facilitates an early step in the assembly of the 50S subunit of the ribosome
YP_311559.1	Code: K; COG: COG0583
YP_311560.1	Code: E; COG: COG1280
YP_311561.1	stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit
YP_311562.1	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YP_311563.1	Code: J; COG: COG0566
YP_311564.1	Code: OC; COG: COG0526
YP_311565.1	Code: S; COG: COG3148
YP_311566.1	Code: C; COG: COG1042
YP_311567.1	catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome
YP_311568.1	Code: R; COG: COG5544
YP_311569.1	Code: GEPR; COG: COG0477
YP_311570.1	Code: O; COG: COG0542
YP_311571.1	Code: S; COG: COG1496
YP_311572.1	responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA
YP_311573.1	with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline
YP_311574.1	Code: L; COG: COG3385
YP_311575.1	Code: R; COG: COG3740
YP_311576.1	Code: L; COG: COG2963
YP_311577.1	Code: L; COG: COG2801
YP_311578.1	Code: R; COG: COG4386
YP_311582.1	Code: L; COG: COG1662
YP_311584.1	Code: R; COG: COG4379
YP_311585.1	Code: S; COG: COG4384
YP_311586.1	Code: S; COG: COG4381
YP_311588.1	Code: L; COG: COG1662
YP_311590.1	Code: S; COG: COG3778
YP_311595.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_311596.1	Code: I; COG: COG2867
YP_311597.2	Code: S; COG: COG2914
YP_311598.1	Code: L; COG: COG3385
YP_311600.1	associated with 30S ribosomal subunit; interferes with translation elongation
YP_311602.1	catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis
YP_311603.1	catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis
YP_311604.1	DAHP synthetase; tyrosine repressible; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive
YP_311606.1	Code: L; COG: COG1662
YP_311608.1	Code: L; COG: COG2801
YP_311609.1	Code: L; COG: COG2963
YP_311610.1	Code: L; COG: COG2963
YP_311611.1	Code: L; COG: COG4584
YP_311612.1	Code: L; COG: COG1484
YP_311613.1	Code: T; COG: COG2199
YP_311614.1	Code: M; COG: COG2885
YP_311615.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_311616.1	methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA
YP_311617.2	Essential for efficient processing of 16S rRNA
YP_311618.1	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity
YP_311619.1	with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins
YP_311620.1	Code: R; COG: COG4137
YP_311621.2	Code: P; COG: COG4536
YP_311622.1	phage lambda replication; host DNA synthesis; protein repair; with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor
YP_311623.1	catalyzes the phosphorylation of NAD to NADP
YP_311624.1	Code: L; COG: COG0497
YP_311625.2	Code: J; COG: COG2913
YP_311627.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_311628.1	Code: L; COG: COG3385
YP_311629.1	Code: S; COG: COG4695
YP_311631.1	Code: R; COG: COG4626
YP_311632.1	Code: L; COG: COG3747
YP_311633.1	Code: V; COG: COG1403
YP_311634.1	similar to bacteriophage lambda endopeptidase
YP_311635.1	similar to bacteriophage lambda lysozyme; Code: R; COG: COG3772
YP_311638.1	similar to cryptic prophage protein
YP_311639.1	encoded by cryptic prophage; Code: L; COG: COG4570
YP_311641.1	Code: L; COG: COG0305
YP_311642.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_311643.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_311646.1	Code: L; COG: COG1662
YP_311647.1	Code: L; COG: COG1662
YP_311648.1	Code: G; COG: COG0366
YP_311649.2	in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution
YP_311650.1	catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate
YP_311651.1	catalyzes the formation of succinate from succinate semialdehyde; NADP dependent
YP_311652.1	catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate
YP_311653.1	Code: E; COG: COG1113
YP_311654.2	regulator of gab gene expression
YP_311655.1	Code: S; COG: COG1652
YP_311656.1	Code: S; COG: COG0401
YP_311657.1	Code: K; COG: COG0640
YP_311658.1	Code: P; COG: COG0607
YP_311659.1	H-NS-like protein; chaperone activity; possibly involved in RNA splicing; Code: R; COG: COG2916
YP_311660.1	Code: L; COG: COG3547
YP_311663.1	Code: S; COG: COG4575
YP_311664.1	hydrogen donor; Code: O; COG: COG0695
YP_311665.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_311666.1	B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE
YP_311667.1	with ProWX is involved in the high-affinity uptake of glycine betaine
YP_311668.1	with ProVX is involved in the high-affinity uptake of glycine betaine
YP_311669.1	with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine
YP_311670.1	major facilitator superfamily; Code: GEPR; COG: COG0477
YP_311671.1	Code: E; COG: COG1296
YP_311673.1	microcin B17 synthesis; DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB
YP_311674.1	Code: V; COG: COG1566
YP_311675.1	multidrug resistance; Code: GEPR; COG: COG0477
YP_311676.1	catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2
YP_311677.1	involved in the first step of glutathione biosynthesis
YP_311678.1	Code: S; COG: COG1238
YP_311679.1	YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent
YP_311680.1	affects carbohydrate metabolism; has regulatory role in many processes
YP_311681.1	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_311682.1	binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities
YP_311683.1	DNA strand exchange and renaturation; DNA- and ATP-dependent coprotease; catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs
YP_311684.1	Code: R; COG: COG1546
YP_311685.1	membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan
YP_311686.1	Code: G; COG: COG3730
YP_311687.1	Code: G; COG: COG3732
YP_311688.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_311689.1	regulator for glucitol utilization
YP_311690.1	regulates genes involved in glucitol utilization
YP_311691.2	catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate
YP_311692.2	Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon
YP_311693.1	detoxifies nitric oxide using NADH
YP_311694.1	catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase
YP_311695.1	Code: O; COG: COG0068
YP_311696.1	involved in electron transport from formate to hydrogen
YP_311697.1	Code: K; COG: COG1609
YP_311698.1	transports specific beta-glucosides; phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_311699.1	Code: G; COG: COG2723
YP_311700.1	Code: K; COG: COG5499
YP_311701.1	Code: S; COG: COG4680
YP_311703.1	involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE
YP_311704.1	processing of large subunit (HycE) of hydrogenase 3 (part of the FHL complex)
YP_311705.1	Code: C; COG: COG3260
YP_311706.1	part of FHL complex; electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate
YP_311707.1	(part of FHL complex); Code: C; COG: COG3261
YP_311708.1	Code: C; COG: COG0650
YP_311709.1	part of FHL complex; catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3)
YP_311710.1	part of formate hydrogenlyase (FHL) complex; Code: C; COG: COG1142
YP_311711.1	regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon
YP_311712.1	pleiotrophic effects on 3 hydrogenase isozymes; plays a role in hydrogenase nickel cofactor insertion
YP_311713.1	functions as nickel donor for large subunit of hydrogenase 3; GTP hydrolase involved in nickel liganding into hydrogenases
YP_311714.1	HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase
YP_311715.1	Code: O; COG: COG0409
YP_311716.1	plays structural role in maturation of all 3 hydrogenases; Code: O; COG: COG0309
YP_311718.1	This protein performs the mismatch recognition step during the DNA repair process
YP_311719.1	Code: L; COG: COG1662
YP_311720.1	Code: KG; COG: COG1349
YP_311721.1	Code: I; COG: COG2084
YP_311722.1	Code: S; COG: COG3395
YP_311723.1	Code: G; COG: COG0235
YP_311724.1	Code: G; COG: COG3622
YP_311725.1	member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function
YP_311726.1	synthesis of many growth phase related proteins; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses
YP_311727.1	outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus
YP_311728.1	catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins
YP_311729.1	catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate
YP_311730.1	catalyzes the modification of U13 in tRNA(Glu)
YP_311731.1	catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
YP_311732.1	4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers
YP_311733.1	forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein
YP_311735.1	converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis
YP_311736.1	ATP:sulfate adenylyltransferase; probably a GTPase; may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ
YP_311737.1	ATP:sulfate adenylyltransferase; with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP
YP_311738.1	catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3
YP_311741.1	Code: L; COG: COG3547
YP_311745.1	Code: L; COG: COG2963
YP_311746.1	Code: L; COG: COG2801
YP_311750.1	Code: R; COG: COG1203
YP_311751.1	catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite
YP_311752.1	hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide
YP_311753.1	catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity
YP_311754.1	Code: H; COG: COG0720
YP_311755.1	Code: C; COG: COG0644
YP_311756.1	Code: C; COG: COG2440
YP_311757.1	Code: K; COG: COG1954
YP_311758.1	Code: C; COG: COG2025
YP_311759.1	Code: C; COG: COG2086
YP_311760.1	Code: GEPR; COG: COG0477
YP_311761.1	Code: C; COG: COG0277
YP_311762.1	Code: GEPR; COG: COG0477
YP_311763.1	Code: L; COG: COG1662
YP_311764.1	Code: O; COG: COG0602
YP_311765.1	Code: L; COG: COG2963
YP_311766.1	Code: L; COG: COG2801
YP_311767.1	Code: R; COG: COG1512
YP_311768.1	Code: L; COG: COG1662
YP_311769.1	Code: L; COG: COG3385
YP_311770.1	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis
YP_311771.1	CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer
YP_311772.1	functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era
YP_311773.1	MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system
YP_311774.1	part of the MazF-MazE toxin-antitoxin system; conteracts MazF
YP_311775.1	regulation of RNA synthesis; stringent factor; GTP pyrophosphokinase; (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP
YP_311776.1	in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]
YP_311777.1	part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system
YP_311778.1	Code: MR; COG: COG4948
YP_311779.1	Code: MR; COG: COG4948
YP_311780.1	Code: GEPR; COG: COG0477
YP_311781.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_311782.1	catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp
YP_311783.1	Code: S; COG: COG3098
YP_311784.1	SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function
YP_311785.1	catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis
YP_311786.1	Code: R; COG: COG1611
YP_311787.1	Code: E; COG: COG0814
YP_311788.1	deaminase; L-SD2; Code: E; COG: COG1760
YP_311789.1	has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups
YP_311790.1	Code: C; COG: COG1454
YP_311791.1	catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate
YP_311792.1	Code: G; COG: COG0738
YP_311793.1	Code: G; COG: COG1070
YP_311794.1	Code: G; COG: COG4154
YP_311795.1	regulates expression of genes involved in L-fucose utilization
YP_311796.1	Code: R; COG: COG2933
YP_311797.1	Code: S; COG: COG2363
YP_311798.1	Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence
YP_311800.1	Code: E; COG: COG0520
YP_311801.1	Code: R; COG: COG2166
YP_311802.1	Code: H; COG: COG1179
YP_311803.1	membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues
YP_311804.1	Code: M; COG: COG0860
YP_311805.1	catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis
YP_311806.1	ssDNA endonuclease; helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity
YP_311807.1	ssDNA endonuclease; helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity
YP_311808.1	Code: O; COG: COG1025
YP_311809.1	catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination
YP_311810.1	Code: NU; COG: COG4967
YP_311812.1	Code: U; COG: COG4795
YP_311813.1	Code: NU; COG: COG2165
YP_311814.1	ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived
YP_311815.1	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein
YP_311816.1	transcriptional regulator (with NPR and NTR proteins); member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr
YP_311817.1	hydrolyzes diadenosine polyphosphate
YP_311818.1	MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair
YP_311819.1	Code: P; COG: COG0861
YP_311821.1	Code: L; COG: COG2801
YP_311822.1	Code: L; COG: COG2963
YP_311823.1	Code: L; COG: COG3385
YP_311824.1	complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH
YP_311825.1	Code: GEPR; COG: COG0477
YP_311826.1	Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1
YP_311827.1	controls transcription of galETKM
YP_311828.1	catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding
YP_311829.1	activates the transcription of the lysA gene encoding diaminopimelate decarboxylase
YP_311830.1	Code: GEPR; COG: COG0477
YP_311831.1	catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate
YP_311832.1	4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
YP_311833.2	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis
YP_311834.1	Code: E; COG: COG0814
YP_311835.1	Code: K; COG: COG2771
YP_311836.1	Code: L; COG: COG1662
YP_311839.1	Code: R; COG: COG0457
YP_311840.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_311841.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_311843.1	Code: M; COG: COG0739
YP_311844.1	molybdenum cofactor-binding protein; participates in purine salvage
YP_311845.1	FAD-binding subunit; with XdhA and XdhC participates in purine salvage
YP_311846.1	iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage
YP_311847.1	Code: KT; COG: COG3829
YP_311848.1	Code: E; COG: COG0078
YP_311849.1	catalyzes the formation of pyruvate from 2,3-diaminopropionate
YP_311850.1	Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases
YP_311851.1	catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP
YP_311852.1	Code: O; COG: COG1975
YP_311854.1	Code: R; COG: COG2068
YP_311855.1	Code: L; COG: COG3385
YP_311856.1	Code: L; COG: COG2801
YP_311857.1	Code: L; COG: COG2963
YP_311858.2	in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS
YP_311859.1	with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain
YP_311860.2	with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration
YP_311863.1	Code: C; COG: COG1142
YP_311864.1	unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic)
YP_311865.1	Code: L; COG: COG3335
YP_311866.1	Code: F; COG: COG2233
YP_311867.1	catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate
YP_311868.1	suppressor of ColE1 mutation in primer RNA; class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_311869.1	5' --> 3' specific; 5'-3' single-stranded-DNA-specific exonuclease
YP_311870.1	DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity
YP_311871.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_311872.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic
YP_311874.1	Code: S; COG: COG2938
YP_311875.1	physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator
YP_311876.1	Code: R; COG: COG1272
YP_311877.1	Code: S; COG: COG3097
YP_311878.1	Code: G; COG: COG2723
YP_311879.1	Code: IQR; COG: COG1028
YP_311880.1	acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine
YP_311881.1	part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor
YP_311882.1	T protein; tetrahydrofolate-dependent; catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein
YP_311883.1	Code: HC; COG: COG0654
YP_311884.1	2-octaprenyl-6-methoxyphenol--> 2-octaprenyl-6-methoxy-1, 4-benzoquinone; Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone
YP_311885.1	exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide
YP_311886.2	the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown
YP_311887.1	Code: S; COG: COG3027
YP_311888.1	ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function
YP_311889.1	catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate
YP_311890.1	Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway
YP_311891.1	specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport
YP_311892.1	MDM; functions in conversion of succinate to propionate
YP_311893.1	functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins
YP_311894.2	catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA
YP_311895.1	Code: C; COG: COG0427
YP_311896.1	Code: L; COG: COG1662
YP_311897.1	Code: S; COG: COG2968
YP_311898.1	Involved in the export of arginine
YP_311899.1	participates in the regulation of osmotic pressure changes within the cel
YP_311900.1	catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate
YP_311901.1	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway
YP_311902.1	NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate
YP_311903.1	Code: R; COG: COG1661
YP_311905.1	Code: P; COG: COG0619
YP_311906.1	Code: P; COG: COG1122
YP_311907.1	Code: P; COG: COG1118
YP_311908.1	Code: H; COG: COG1072
YP_311909.1	Code: L; COG: COG1662
YP_311910.1	TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein
YP_311911.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_311912.1	Code: O; COG: COG0501
YP_311913.1	catalyzes the formation of putrescine from agmatine
YP_311914.1	catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis
YP_311918.1	catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_311919.1	Code: GEPR; COG: COG0477
YP_311920.1	Code: S; COG: COG3091
YP_311921.1	Code: L; COG: COG2356
YP_311922.2	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase
YP_311923.1	catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione
YP_311924.2	Code: K; COG: COG1678
YP_311925.1	similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function
YP_311926.1	Code: NU; COG: COG2805
YP_311927.1	Code: R; COG: COG0325
YP_311928.1	Code: S; COG: COG0762
YP_311929.2	Code: S; COG: COG1872
YP_311930.1	HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine
YP_311931.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_311933.1	Code: G; COG: COG1638
YP_311934.1	Code: L; COG: COG1662
YP_311935.1	Code: L; COG: COG3335
YP_311936.1	Code: L; COG: COG1662
YP_311937.1	Code: P; COG: COG0861
YP_311938.1	Code: R; COG: COG0673
YP_311939.1	Code: S; COG: COG2949
YP_311940.1	Code: R; COG: COG1451
YP_311941.1	Code: J; COG: COG2813
YP_311942.1	Code: S; COG: COG4680
YP_311943.1	Code: K; COG: COG5499
YP_311944.1	Code: C; COG: COG1902
YP_311947.1	Code: L; COG: COG1662
YP_311948.1	Code: L; COG: COG1662
YP_311949.1	Code: L; COG: COG3335
YP_311951.1	Code: P; COG: COG0306
YP_311952.1	catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction
YP_311953.1	YghU; B2989; one of eight  glutathione transferase proteins from E. coli
YP_311954.1	Code: O; COG: COG0298
YP_311955.1	may modulate levels of hydrogenease-2; plays a role in hydrogenase nickel cofactor insertion
YP_311957.1	protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC)
YP_311958.1	involved in hydrogen uptake
YP_311959.1	HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits
YP_311960.1	Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2
YP_311961.1	involved in hydrogen uptake
YP_311963.1	Code: Q; COG: COG0412
YP_311964.1	Code: C; COG: COG0667
YP_311965.1	Code: S; COG: COG2862
YP_311966.1	Code: IQR; COG: COG1028
YP_311967.1	membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell
YP_311968.1	membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell
YP_311970.1	beta-cystathionase; catalyzes the formation of L-homocysteine from cystathionine
YP_311971.1	Code: S; COG: COG0586
YP_311972.1	Code: K; COG: COG2207
YP_311973.1	Code: C; COG: COG1979
YP_311974.2	methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate
YP_311976.1	Code: M; COG: COG4238
YP_311977.1	Code: C; COG: COG1032
YP_311978.1	Code: Q; COG: COG2132
YP_311979.1	Code: I; COG: COG0204
YP_311980.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_311981.1	Code: L; COG: COG3449
YP_311982.1	Code: S; COG: COG3111
YP_311983.1	similar to quorum sensing Escherichia coli regulator B; response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes
YP_311984.1	similar to quorum sensing Escherichia coli regulator C; Code: T; COG: COG0642
YP_311985.1	Code: R; COG: COG2249
YP_311986.1	Code: S; COG: COG1359
YP_311987.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_311988.1	Displays esterase activity toward palmitoyl-CoA and pNP-butyrate
YP_311989.1	Code: R; COG: COG1409
YP_311990.1	Code: S; COG: COG3151
YP_311991.1	ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose
YP_311992.2	outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes; trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell
YP_311993.2	Code: S; COG: COG5463
YP_311994.1	Code: E; COG: COG0754
YP_311995.1	seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine
YP_311996.1	Code: P; COG: COG0428
YP_311997.1	DHBP synthase; functions during riboflavin biosynthesis
YP_311998.1	Code: S; COG: COG2960
YP_311999.1	Code: NU; COG: COG3539
YP_312000.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_312001.1	Code: NU; COG: COG3121
YP_312003.1	Code: L; COG: COG3335
YP_312004.1	Involved in glycogen synthesis. May be involved in glycogen priming
YP_312006.1	Code: S; COG: COG2268
YP_312007.1	catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose
YP_312008.1	catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme
YP_312009.1	Code: S; COG: COG3025
YP_312010.1	Code: T; COG: COG3103
YP_312011.1	catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases
YP_312012.1	bacitracin resistance; BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell
YP_312013.1	catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin
YP_312014.1	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX
YP_312015.1	Involved in the tartrate degradation pathway
YP_312016.1	Involved in the tartrate degradation pathway
YP_312017.1	Code: P; COG: COG0471
YP_312018.1	in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity
YP_312019.1	a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA
YP_312020.1	DNA biosynthesis; synthesizes RNA primers at the replication forks
YP_312021.1	regulation of proteins induced at high temperatures; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria
YP_312022.1	Code: L; COG: COG3385
YP_312023.1	Code: L; COG: COG3663
YP_312024.1	Code: P; COG: COG2375
YP_312025.1	Code: K; COG: COG1695
YP_312026.1	Code: NT; COG: COG0840
YP_312027.2	catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate
YP_312028.1	Code: R; COG: COG0073
YP_312029.1	Code: K; COG: COG1609
YP_312030.1	Code: L; COG: COG3385
YP_312031.1	Code: G; COG: COG3250
YP_312032.1	in Escherichia coli this is the second beta-galactosidase system
YP_312034.1	Code: L; COG: COG3335
YP_312037.1	Code: R; COG: COG2244
YP_312038.1	Code: L; COG: COG1662
YP_312041.1	Code: L; COG: COG1112
YP_312042.1	Code: L; COG: COG3547
YP_312043.1	Code: R; COG: COG1811
YP_312044.1	Code: E; COG: COG1982
YP_312045.1	Code: L; COG: COG3547
YP_312046.1	Code: GEPR; COG: COG0477
YP_312047.1	Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues
YP_312048.1	Code: CO; COG: COG2924
YP_312049.1	G.C --> T.A transversions; Code: L; COG: COG1194
YP_312050.1	tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine
YP_312051.2	Code: S; COG: COG3171
YP_312053.1	catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis
YP_312054.1	Code: L; COG: COG1662
YP_312055.1	involved in the import of serine and threonine coupled with the import of sodium
YP_312057.1	Code: G; COG: COG2721
YP_312058.1	catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism
YP_312061.1	Code: L; COG: COG3335
YP_312063.1	Code: L; COG: COG1662
YP_312065.1	regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.
YP_312066.1	Code: S; COG: COG0586
YP_312069.1	Code: S; COG: COG4575
YP_312070.1	Code: S; COG: COG5393
YP_312072.1	Code: S; COG: COG2259
YP_312073.1	Code: O; COG: COG0435
YP_312074.1	Code: S; COG: COG3152
YP_312075.1	Code: S; COG: COG3152
YP_312076.1	Code: R; COG: COG1741
YP_312078.1	Code: S; COG: COG3681
YP_312079.1	Code: E; COG: COG0814
YP_312080.1	Code: E; COG: COG1760
YP_312081.1	Code: J; COG: COG0251
YP_312082.1	Code: C; COG: COG1882
YP_312083.1	catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism
YP_312084.1	involved in the import of threonine and serine in combination with the import of a proton
YP_312085.1	catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic
YP_312086.1	regulates the tdcABCDEFG operon which is involved in amino acid degradation
YP_312087.1	participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon
YP_312088.1	Code: L; COG: COG1662
YP_312090.2	Code: G; COG: COG1929
YP_312091.2	catalyzes the reduction of tartronate semialdehyde to glycerate
YP_312092.1	cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate
YP_312093.1	Code: GEPR; COG: COG0477
YP_312094.1	Code: G; COG: COG2721
YP_312095.1	Code: L; COG: COG2963
YP_312096.1	Code: L; COG: COG2801
YP_312098.1	Code: L; COG: COG1662
YP_312099.1	Code: NU; COG: COG3188
YP_312100.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_312101.1	Code: NU; COG: COG3539
YP_312102.1	Code: R; COG: COG0313
YP_312103.1	Code: R; COG: COG3107
YP_312104.1	Code: L; COG: COG0792
YP_312105.1	Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein
YP_312106.1	Code: R; COG: COG2823
YP_312107.1	Code: R; COG: COG0701
YP_312108.1	Code: MG; COG: COG0702
YP_312109.1	Code: R; COG: COG0693
YP_312110.1	Code: S; COG: COG3787
YP_312111.1	Code: L; COG: COG2827
YP_312112.1	Code: R; COG: COG3153
YP_312113.1	Code: I; COG: COG3154
YP_312114.1	Code: O; COG: COG0826
YP_312115.1	Code: O; COG: COG0826
YP_312116.1	Code: C; COG: COG2141
YP_312117.1	tryptophan transporter of high affinity
YP_312118.2	participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division
YP_312119.1	lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing
YP_312120.1	cytidylate kinase activity; Code: J; COG: COG1185
YP_312121.1	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence
YP_312122.1	catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs
YP_312123.1	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_312124.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_312125.1	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination
YP_312126.2	in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins
YP_312127.1	Code: L; COG: COG4584
YP_312128.1	Code: L; COG: COG1484
YP_312129.1	catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis
YP_312130.1	Code: R; COG: COG2194
YP_312131.1	protein export - membrane protein; Code: U; COG: COG1314
YP_312132.1	similar to phosphoglucomutases and phosphomannomutases; catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YP_312133.2	catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate
YP_312134.1	inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins
YP_312135.1	Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit
YP_312136.1	RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability
YP_312137.2	cleaves 3' nucleotide of paused mRNA; necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_312138.1	penicillin-binding protein 4; penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains
YP_312139.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_312140.1	Code: GER; COG: COG0697
YP_312141.1	involved in the peptidyltransferase reaction during translation
YP_312142.1	Code: J; COG: COG0261
YP_312143.1	Code: H; COG: COG0142
YP_312144.1	activator of maltose metabolism genes
YP_312145.1	first step in murein biosynthesis; adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_312146.1	Code: K; COG: COG5007
YP_312147.1	Code: R; COG: COG3113
YP_312148.1	Code: Q; COG: COG2854
YP_312149.1	Code: Q; COG: COG1463
YP_312150.1	Code: Q; COG: COG0767
YP_312151.1	ATP-binding subunit of a  ABC toluene efflux transporter
YP_312152.1	YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers
YP_312153.1	Code: M; COG: COG0794
YP_312154.1	forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis
YP_312155.1	Code: S; COG: COG3117
YP_312156.1	LptA; periplasmic binding protein part of a  ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system
YP_312157.1	Code: R; COG: COG1137
YP_312158.1	nitrogen and fermentation regulation; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen
YP_312159.1	YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing
YP_312160.1	Code: GT; COG: COG1762
YP_312161.1	Code: R; COG: COG1660
YP_312162.1	nitrogen-related; exchanges phosphate with enzyme I; Hpr; Code: G; COG: COG1925
YP_312164.1	glycosyltransferase; polymerizes glycan strands in the peptidoglycan
YP_312165.1	Code: Q; COG: COG3155
YP_312166.1	aerobic respiration sensor-response protein; sensor for arcA; sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA
YP_312167.1	Code: R; COG: COG1242
YP_312168.1	catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate
YP_312169.1	glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate
YP_312170.1	Code: G; COG: COG2731
YP_312171.2	catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein
YP_312172.1	Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate
YP_312173.2	Code: GEPR; COG: COG0477
YP_312174.1	aldolase; catabolism of sialic acid; catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid
YP_312175.1	Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization
YP_312176.1	YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic
YP_312177.1	Code: R; COG: COG2969
YP_312178.1	transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation
YP_312179.1	forms a direct contact with the tRNA during translation
YP_312180.1	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_312181.1	Code: R; COG: COG1485
YP_312182.1	Code: S; COG: COG3105
YP_312183.1	Code: O; COG: COG0265
YP_312184.1	Code: O; COG: COG0265
YP_312185.1	Code: L; COG: COG3385
YP_312186.1	oxidizes malate to oxaloacetate
YP_312187.1	regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes
YP_312189.1	Code: K; COG: COG2732
YP_312190.1	with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate
YP_312191.1	with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate
YP_312192.2	membrane protein AaeX; the gene is a member of the aaeXAB operon
YP_312193.1	responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA
YP_312194.1	Code: S; COG: COG3164
YP_312195.2	involved in the processing of the 5'end of 16S rRNA
YP_312196.1	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell
YP_312197.1	part of cell wall structural complex MreBCD; transmembrane component
YP_312198.1	in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall
YP_312199.2	penicillin binding protein 3; septation function; functions in MreBCD complex in some organisms
YP_312200.1	regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules
YP_312201.1	Code: CR; COG: COG0604
YP_312203.1	carrier of biotin; composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_312204.1	an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_312205.1	Code: S; COG: COG3924
YP_312206.2	mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase
YP_312207.1	methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype
YP_312208.1	Code: J; COG: COG0042
YP_312209.1	DNA-binding protein; Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription
YP_312210.2	Code: L; COG: COG0863
YP_312212.1	Code: K; COG: COG1309
YP_312213.1	transmembrane protein affects septum formation and cell membrane permeability; Code: M; COG: COG0845
YP_312214.1	Code: L; COG: COG1662
YP_312215.1	Code: ET; COG: COG0834
YP_312216.1	Code: E; COG: COG0765
YP_312217.1	Code: E; COG: COG1126
YP_312218.1	Code: R; COG: COG0663
YP_312220.1	AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate
YP_312221.1	RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA
YP_312222.1	Code: S; COG: COG2922
YP_312223.1	involved in DNA uptake; Code: LU; COG: COG0758
YP_312224.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_312225.1	modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth
YP_312226.1	catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase
YP_312227.1	involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain
YP_312228.1	forms homopentamer; channel that opens in response to pressure or hypoosmotic shock
YP_312229.1	Code: S; COG: COG3036
YP_312230.1	mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators
YP_312232.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_312233.1	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme
YP_312234.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_312235.1	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3
YP_312236.1	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA
YP_312237.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif
YP_312238.1	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase
YP_312239.1	late assembly protein
YP_312240.1	L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7
YP_312241.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_312242.1	binds 5S rRNA along with protein L5 and L25
YP_312243.1	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance
YP_312244.1	includes regulator; binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_312245.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif
YP_312246.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_312247.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_312248.1	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase
YP_312249.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_312250.1	one of the stabilizing components for the large ribosomal subunit
YP_312251.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_312252.1	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation
YP_312253.1	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center
YP_312254.1	Code: J; COG: COG0185
YP_312255.1	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation
YP_312256.1	binds third domain of 23S rRNA and protein L29; part of exit tunnel
YP_312257.1	regulates expression of S10 operon; L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_312258.1	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin
YP_312259.1	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex
YP_312260.1	calcium-binding protein that may be required for the initiation of chromosome replication
YP_312261.1	Code: L; COG: COG1484
YP_312262.1	Code: L; COG: COG4584
YP_312263.1	Code: L; COG: COG1662
YP_312264.1	duplicate of tufB; EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_312265.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_312266.1	initiates assembly; binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit
YP_312267.1	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance
YP_312268.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_312269.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_312270.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_312271.1	Code: S; COG: COG2964
YP_312272.1	rotamase
YP_312273.1	Code: S; COG: COG2900
YP_312274.1	rotamase
YP_312275.1	Code: R; COG: COG3529
YP_312276.1	involved in potassium efflux
YP_312277.1	required for KefB activity
YP_312278.1	Code: R; COG: COG0488
YP_312279.1	Code: R; COG: COG0429
YP_312280.1	Code: S; COG: COG3089
YP_312281.1	Code: C; COG: COG3954
YP_312282.1	Code: O; COG: COG1765
YP_312283.1	complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons
YP_312284.1	Code: S; COG: COG1289
YP_312285.1	DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate
YP_312286.1	aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity
YP_312287.1	induced in stationary phase, recognized by rpoS, affects cell division; Code: D; COG: COG2184
YP_312289.1	rotamase A; Code: O; COG: COG0652
YP_312290.1	Code: GEPR; COG: COG0477
YP_312291.1	Code: C; COG: COG1251
YP_312292.1	involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations
YP_312293.1	member of the FNT family of formate and nitrite transporters
YP_312294.1	multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin
YP_312296.1	Code: L; COG: COG1662
YP_312297.1	inner membrane protein possibly involved in fructoselysine transport; member of the flr operon
YP_312298.1	catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine
YP_312299.1	Code: G; COG: COG1082
YP_312300.1	Code: G; COG: COG0524
YP_312301.1	may act as a transcriptional regulator of a fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes
YP_312305.1	phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE)
YP_312308.1	catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_312309.1	catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate
YP_312310.1	catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate
YP_312311.1	Code: L; COG: COG0338
YP_312312.1	interferes with cell division; Code: S; COG: COG3266
YP_312313.1	catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
YP_312314.1	type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_312315.1	outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa
YP_312319.2	bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits
YP_312320.1	ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose
YP_312322.1	Code: R; COG: COG1011
YP_312323.1	Code: J; COG: COG1188
YP_312324.2	becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers
YP_312325.1	PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP
YP_312326.1	membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR
YP_312327.1	sensor; EnvZ; part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation
YP_312328.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_312329.1	Code: K; COG: COG2183
YP_312330.1	Code: P; COG: COG1918
YP_312331.1	cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake
YP_312333.1	Code: L; COG: COG1662
YP_312334.1	reaction prior to pimeloyl CoA; Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis
YP_312335.2	involved in high-affinity gluconate transport
YP_312336.1	cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source
YP_312337.1	Code: GE; COG: COG2610
YP_312338.1	amylomaltase; amylomaltase; acts to release glucose from maltodextrins
YP_312339.1	Code: G; COG: COG0058
YP_312340.1	Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides
YP_312341.1	catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester
YP_312342.1	Code: S; COG: COG1690
YP_312343.1	Code: L; COG: COG1662
YP_312344.1	Confers resistance to chloramphenicol
YP_312345.1	Involved in anaerobic NO protection
YP_312346.1	Code: H; COG: COG2091
YP_312347.1	Code: R; COG: COG2252
YP_312348.1	YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily
YP_312349.1	might be involved in hypersensitivity to nitrofurzone
YP_312350.1	Code: L; COG: COG1662
YP_312351.1	Code: L; COG: COG1662
YP_312353.1	Code: L; COG: COG3385
YP_312354.1	cytoplasmic; catalyzes the hydrolysis of trehalose to glucose
YP_312355.1	Code: P; COG: COG1858
YP_312356.1	Code: E; COG: COG0076
YP_312357.1	regulates genes in response to acid and/or during stationary phase
YP_312358.1	Code: K; COG: COG2207
YP_312359.1	Code: V; COG: COG0841
YP_312360.1	with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds
YP_312361.1	Code: K; COG: COG2771
YP_312362.1	Code: S; COG: COG3247
YP_312363.1	inactive form
YP_312365.1	inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli
YP_312366.1	Code: K; COG: COG2771
YP_312367.1	Code: M; COG: COG3065
YP_312368.1	Code: L; COG: COG1662
YP_312370.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_312371.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_312372.1	Code: L; COG: COG2801
YP_312373.1	Code: L; COG: COG2963
YP_312374.1	Code: R; COG: COG0701
YP_312375.1	Code: L; COG: COG1484
YP_312376.1	Code: L; COG: COG4584
YP_312378.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_312379.1	Code: L; COG: COG2963
YP_312382.1	Code: L; COG: COG2963
YP_312383.1	Code: L; COG: COG2801
YP_312384.1	Code: L; COG: COG3547
YP_312386.1	Code: GEPR; COG: COG0477
YP_312388.1	Code: J; COG: COG1670
YP_312389.1	Code: Q; COG: COG4264
YP_312390.1	Code: Q; COG: COG3486
YP_312391.1	Code: P; COG: COG1629
YP_312392.1	Code: L; COG: COG1662
YP_312393.1	Code: L; COG: COG2801
YP_312394.1	Code: L; COG: COG2801
YP_312395.1	Code: L; COG: COG2963
YP_312398.1	Code: L; COG: COG1662
YP_312399.1	Code: P; COG: COG1464
YP_312401.2	Code: G; COG: COG2814
YP_312403.1	Code: L; COG: COG1662
YP_312404.1	xanthine synthesis; catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type
YP_312405.1	cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate
YP_312406.1	membrane protein regulates uhpT expression
YP_312407.1	Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph
YP_312408.1	response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter
YP_312409.1	with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit
YP_312410.1	Code: EH; COG: COG0028
YP_312412.1	multidrug resistance; multidrug efflux protein involved in adaptation to low energy shock
YP_312413.1	Code: R; COG: COG0641
YP_312415.1	Code: S; COG: COG2149
YP_312417.1	Code: L; COG: COG0675
YP_312418.1	Code: G; COG: COG1263
YP_312419.1	Code: K; COG: COG2188
YP_312420.2	Code: R; COG: COG2985
YP_312421.2	16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent
YP_312422.1	with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress
YP_312423.2	Code: R; COG: COG5645
YP_312425.2	FAD/NAD(P)-binding domain
YP_312426.1	Code: GEPR; COG: COG0477
YP_312427.1	Code: G; COG: COG3734
YP_312428.1	Code: K; COG: COG2186
YP_312430.1	YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins
YP_312431.1	Code: S; COG: COG3753
YP_312432.1	type II topoisomerase; ATPase activity; negatively supercoils closed circular double-stranded DNA
YP_312433.1	ATP binding; Required for DNA replication; binds preferentially to single-stranded, linear DNA
YP_312434.1	binds the polymerase to DNA and acts as a sliding clamp
YP_312435.1	DNA biosynthesis; initiation of chromosome replication; can be transcription regulator; binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself
YP_312436.1	in Escherichia coli transcription of this gene is enhanced by polyamines
YP_312437.1	protein C5; processes tRNA; 4.5S RNA; protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates
YP_312438.1	Code: S; COG: COG0759
YP_312439.1	functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria
YP_312440.1	in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE
YP_312441.1	Code: L; COG: COG1662
YP_312442.1	represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism
YP_312443.1	protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity
YP_312444.1	belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine
YP_312445.1	in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane
YP_312448.1	Code: P; COG: COG0226
YP_312449.1	Code: L; COG: COG3385
YP_312450.1	Code: G; COG: COG0058
YP_312451.1	catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose
YP_312452.1	catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate
YP_312453.1	catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen
YP_312454.1	catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain
YP_312455.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_312456.1	YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP)
YP_312457.1	Code: LU; COG: COG0758
YP_312458.1	Code: L; COG: COG1662
YP_312459.1	Code: L; COG: COG0514
YP_312460.1	Code: GE; COG: COG2610
YP_312461.2	thermoresistant; thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate
YP_312462.1	Code: K; COG: COG1609
YP_312463.1	Code: R; COG: COG1741
YP_312464.1	Code: R; COG: COG0673
YP_312465.1	YhhY; regulated by the fur regulator; unknown function
YP_312466.1	Code: L; COG: COG1662
YP_312467.1	Code: E; COG: COG0405
YP_312469.1	hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate
YP_312470.2	part of the UgpABCE glycerol-3-phosphate uptake system
YP_312471.1	integral membrane protein; with UgpABC is involved in uptake of glycerol-3-phosphate
YP_312472.1	with UgpEC is involved in the uptake of glycerol-3-phosphate
YP_312473.2	with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine
YP_312474.1	Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine
YP_312475.1	Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine
YP_312476.1	LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter
YP_312477.1	Code: E; COG: COG0683
YP_312479.1	Code: E; COG: COG0683
YP_312480.1	regulation of proteins induced at high temperatures; binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters
YP_312481.1	ABC transporter, membrane protein
YP_312482.1	ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions
YP_312483.1	signal recognition protein receptor; functions in the targeting and insertion of membrane proteins
YP_312484.1	catalyzes the methylation of 16S rRNA at position G966
YP_312485.1	Code: S; COG: COG3776
YP_312487.1	Code: S; COG: COG3714
YP_312488.1	P-type ATPase involved in the export of lead, cadmium, zinc and mercury
YP_312489.1	TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs
YP_312490.1	Code: S; COG: COG1738
YP_312492.2	Code: GEPR; COG: COG0477
YP_312493.1	Code: R; COG: COG0628
YP_312494.1	Code: H; COG: COG2091
YP_312495.1	Code: E; COG: COG0747
YP_312496.1	with NikACDE is involved in nickel transport into the cell
YP_312497.1	with NikABDE is involved in nickel transport into the cell
YP_312498.1	with NikABCE is involved in nickel transport into the cell
YP_312499.1	with NikABCD is involved with nickel transport into the cell
YP_312500.1	Inhibits transcription at high concentrations of nickel
YP_312501.1	Code: S; COG: COG4226
YP_312502.1	Code: V; COG: COG0842
YP_312503.1	Code: V; COG: COG1131
YP_312504.1	Code: M; COG: COG0845
YP_312508.1	Code: R; COG: COG2081
YP_312509.1	Code: P; COG: COG0306
YP_312510.1	ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress
YP_312511.1	possible broad regulatory function; Code: T; COG: COG0589
YP_312512.1	member of the POT family of peptide transporters; probable proton-dependent peptide transporter function
YP_312513.1	predicted SAM-dependent methyltransferase
YP_312514.1	Code: E; COG: COG0339
YP_312515.1	Code: R; COG: COG2961
YP_312516.1	catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense
YP_312517.1	regulates the expression of of the arsRBC involved in resistance to arsenic
YP_312518.1	Code: P; COG: COG1055
YP_312519.1	Code: P; COG: COG1393
YP_312520.1	Code: K; COG: COG0640
YP_312521.1	Code: L; COG: COG4584
YP_312522.1	Code: L; COG: COG1484
YP_312525.1	Code: L; COG: COG0582
YP_312526.1	Code: G; COG: COG2211
YP_312527.1	Code: L; COG: COG1662
YP_312528.1	Code: L; COG: COG3385
YP_312530.1	Code: F; COG: COG2233
YP_312531.1	Code: E; COG: COG0786
YP_312532.1	catalyzes branch migration in Holliday junction intermediates
YP_312533.1	specifically modifies tRNA at position G18
YP_312534.1	also guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Code: TK; COG: COG0317
YP_312535.1	promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
YP_312536.1	Essential for recycling GMP and indirectly, cGMP
YP_312538.1	this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+
YP_312539.1	Code: S; COG: COG2860
YP_312541.1	Code: S; COG: COG1561
YP_312542.1	RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs
YP_312543.1	involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_312544.2	FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly
YP_312545.1	catalyzes the formation of dUMP from dUTP
YP_312546.2	catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine
YP_312547.1	Code: L; COG: COG1662
YP_312548.1	required for 70S ribosome assembly
YP_312549.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif
YP_312550.1	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases
YP_312551.1	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA
YP_312552.1	catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A
YP_312553.1	Code: M; COG: COG0859
YP_312554.1	Code: M; COG: COG0438
YP_312556.1	Code: M; COG: COG1442
YP_312557.1	Code: M; COG: COG1442
YP_312559.1	Code: M; COG: COG1442
YP_312560.1	Code: M; COG: COG0463
YP_312562.1	lipopolysaccharide core biosynthesis; Code: M; COG: COG0859
YP_312563.1	lipopolysaccharide core biosynthesis; catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core
YP_312564.1	catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose
YP_312565.1	glycine acetyltransferase; catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine
YP_312566.1	converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism
YP_312567.1	Code: L; COG: COG1662
YP_312568.1	Code: S; COG: COG2861
YP_312569.1	Code: D; COG: COG4942
YP_312570.1	catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
YP_312571.1	Code: P; COG: COG0607
YP_312572.1	Code: O; COG: COG0695
YP_312573.1	protein export; molecular chaperone; may bind to signel sequence; molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA
YP_312574.1	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_312575.1	catalyzes the O-acetylation of serine
YP_312576.1	member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates
YP_312577.1	flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration
YP_312578.1	represses the lctPRD operon
YP_312579.1	Code: C; COG: COG1620
YP_312580.1	Code: UW; COG: COG5295
YP_312584.1	Acts as a repressor of the mtlAD operon
YP_312585.1	Code: G; COG: COG0246
YP_312586.1	Code: G; COG: COG2213
YP_312588.1	Code: L; COG: COG4584
YP_312589.1	Code: V; COG: COG1566
YP_312590.1	Code: M; COG: COG3209
YP_312593.1	Code: O; COG: COG0625
YP_312594.1	catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis
YP_312595.1	Code: J; COG: COG3276
YP_312596.1	Code: L; COG: COG1662
YP_312597.1	catalyzes the interconversion of D-xylose to D-xylulose
YP_312598.1	Code: G; COG: COG1070
YP_312599.1	Code: S; COG: COG4682
YP_312600.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_312601.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_312602.1	Code: L; COG: COG2963
YP_312603.1	Code: L; COG: COG2801
YP_312604.1	Code: S; COG: COG3274
YP_312606.1	glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_312607.1	glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_312609.1	Code: K; COG: COG1278
YP_312610.1	Code: K; COG: COG2944
YP_312612.2	Code: CHR; COG: COG1052
YP_312613.1	Code: M; COG: COG2885
YP_312614.1	Code: L; COG: COG2801
YP_312615.1	Code: L; COG: COG2963
YP_312616.1	Code: C; COG: COG0243
YP_312617.1	Code: KR; COG: COG0454
YP_312618.1	constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine
YP_312619.1	Code: N; COG: COG5571
YP_312620.1	Code: GEPR; COG: COG0477
YP_312621.2	catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide
YP_312622.1	Code: E; COG: COG0747
YP_312623.1	transports peptides consisting of two or three amino acids
YP_312624.1	Code: EP; COG: COG1173
YP_312625.1	DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF
YP_312626.1	Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides
YP_312627.1	Code: E; COG: COG0814
YP_312631.1	Code: L; COG: COG1662
YP_312633.1	Code: D; COG: COG1192
YP_312634.1	binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP)
YP_312635.1	catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans
YP_312636.1	HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a  phosphodiesterase protein from E. coli
YP_312637.1	involved in the transport of C4-dicarboxylates across the membrane
YP_312638.1	Code: R; COG: COG0612
YP_312639.1	Code: G; COG: COG0524
YP_312640.1	in Escherichia coli this protein is involved in flagellar function
YP_312641.1	Code: M; COG: COG2982
YP_312642.1	Code: GEPR; COG: COG0477
YP_312643.1	Code: S; COG: COG1295
YP_312644.1	Code: K; COG: COG0583
YP_312645.1	Code: TK; COG: COG2197
YP_312646.1	Code: L; COG: COG3385
YP_312647.2	interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase
YP_312648.1	contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA
YP_312649.1	catalyzes the formation of asparagine from aspartate and ammonia
YP_312650.1	transcriptional repressor of asnA which codes for aspartate-ammonia ligase
YP_312651.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_312652.1	glucose-inhibited division; possibly involved in chromosome replication; GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs
YP_312653.1	glucose-inhibited division; possibly involved in chromosome replication; glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA
YP_312654.2	dispensable protein; affects expression of atpB; Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation
YP_312655.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0
YP_312656.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0
YP_312657.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.
YP_312658.1	Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex
YP_312659.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit
YP_312660.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_312661.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit
YP_312662.1	part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane
YP_312663.1	forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis
YP_312664.1	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
YP_312670.1	streptomycin 3'-adenyltransferase
YP_312671.1	Code: L; COG: COG3385
YP_312672.1	Code: NU; COG: COG3539
YP_312673.1	Code: NU; COG: COG3121
YP_312674.1	Code: L; COG: COG1662
YP_312675.1	Code: L; COG: COG2801
YP_312676.1	Code: NU; COG: COG3539
YP_312677.1	Code: P; COG: COG0226
YP_312678.1	part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions
YP_312679.1	Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions
YP_312680.1	ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation
YP_312681.1	regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon
YP_312682.1	positive regulator of the beta-glucoside operon; transcriptional antiterminator
YP_312683.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_312684.1	Code: L; COG: COG3547
YP_312685.1	Code: G; COG: COG4580
YP_312686.1	Code: L; COG: COG3385
YP_312687.1	Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH
YP_312688.2	membrane-associated protein; cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source
YP_312689.1	with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain
YP_312690.1	functions to transport ribose at high affinity; forms a complex with RbsA2C2B
YP_312691.1	catalyzes the formation of D-ribose 5-phosphate from ribose
YP_312692.1	DNA-binding transcriptional repressor of ribose metabolism
YP_312693.1	Code: GEPR; COG: COG0477
YP_312694.1	Code: K; COG: COG2186
YP_312695.1	Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon
YP_312696.1	Code: S; COG: COG3085
YP_312697.1	Code: L; COG: COG1484
YP_312698.1	Code: L; COG: COG4584
YP_312699.1	Code: L; COG: COG1662
YP_312701.1	catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit
YP_312702.1	Code: S; COG: COG3978
YP_312703.1	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_312704.1	catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
YP_312705.1	dehydratase; threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway
YP_312706.1	participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate
YP_312707.1	catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis
YP_312708.1	rotamase C; Code: O; COG: COG0760
YP_312709.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_312710.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_312711.1	single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication
YP_312712.1	catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation
YP_312713.1	enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation
YP_312714.1	Code: OC; COG: COG0526
YP_312716.1	An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes
YP_312718.1	synthesis of enterobacterial common antigen (ECA); Code: M; COG: COG0472
YP_312719.1	Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein
YP_312720.1	Code: M; COG: COG0381
YP_312721.1	synthesis of enterobacterial common antigen (ECA); catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid
YP_312722.1	Code: M; COG: COG1088
YP_312723.1	Code: M; COG: COG1209
YP_312724.1	Code: KR; COG: COG0454
YP_312725.1	catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis
YP_312726.1	Code: R; COG: COG2244
YP_312727.1	catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis
YP_312728.1	synthesis of enterobacterial common antigen (ECA); enterobacterial common antigen polymerase
YP_312729.1	synthesis of enterobacterial common antigen (ECA); Code: M; COG: COG1922
YP_312730.1	uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function
YP_312731.1	Code: R; COG: COG0641
YP_312732.1	a late step of protoheme IX synthesis; Code: H; COG: COG3071
YP_312733.1	Code: H; COG: COG2959
YP_312734.1	catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis
YP_312735.1	hydroxymethylbilane synthase; transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis
YP_312736.1	catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP
YP_312737.1	defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly
YP_312739.1	Code: N; COG: COG5567
YP_312740.2	involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate
YP_312741.1	Code: S; COG: COG3159
YP_312742.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_312743.1	YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function
YP_312744.1	unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.
YP_312745.1	Code: S; COG: COG1912
YP_312746.1	Code: L; COG: COG3385
YP_312748.1	responsible for the influx of magnesium ions
YP_312749.1	Code: L; COG: COG1662
YP_312750.1	Code: R; COG: COG2962
YP_312751.2	Code: Q; COG: COG2050
YP_312752.1	catalyzes the hydrolysis of phosphatidylcholine
YP_312753.1	functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway
YP_312754.1	Code: E; COG: COG1280
YP_312755.1	Code: E; COG: COG1280
YP_312756.1	lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates
YP_312757.1	purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium
YP_312758.1	Code: GER; COG: COG0697
YP_312759.1	Code: K; COG: COG0583
YP_312760.1	catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine
YP_312761.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_312762.1	Code: Q; COG: COG0412
YP_312763.1	catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway
YP_312764.1	YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner
YP_312765.1	Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone
YP_312766.1	Code: S; COG: COG3165
YP_312767.1	an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions
YP_312768.1	TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes
YP_312769.2	mediates the export of protein precursors bearing twin-arginine signal peptides
YP_312770.1	with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane
YP_312771.1	magnesium dependent; not involved in the Sec-independent protein export system
YP_312772.1	Code: K; COG: COG0250
YP_312773.1	catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol
YP_312774.1	flavin reductase (NADPH:flavin oxidoreductase); NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin
YP_312775.1	3-ketoacyl-CoA thiolase; acetyl-CoA transferase; FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids
YP_312776.1	4-enzyme protein; includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids
YP_312777.1	catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters
YP_312778.1	Code: S; COG: COG1739
YP_312779.1	Code: P; COG: COG0168
YP_312780.1	catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX
YP_312781.1	in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway
YP_312782.1	molybdopterin ---> molybdopterin-guanine dinucleotide, protein Ar; in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis
YP_312783.1	Code: S; COG: COG3084
YP_312784.1	catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages
YP_312785.1	essential for cytochrome c synthesis and formate-dependent reduction; Code: OC; COG: COG0526
YP_312786.1	Code: L; COG: COG1662
YP_312787.1	Code: I; COG: COG0204
YP_312788.1	3' --> 5' polymerase; 5' --> 3' and 3' --> 5' exonuclease; has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair
YP_312789.2	binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential
YP_312790.1	Code: S; COG: COG3078
YP_312791.2	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_312792.1	sensor glnL; nitrogen regulator I, NRI; response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54
YP_312793.1	nitrogen regulator II; NRII; sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation
YP_312794.1	forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme
YP_312795.1	Code: T; COG: COG1217
YP_312796.1	Code: L; COG: COG3385
YP_312797.1	Code: KG; COG: COG1349
YP_312798.1	Code: L; COG: COG3385
YP_312799.1	Code: G; COG: COG0524
YP_312800.1	Code: I; COG: COG2084
YP_312801.1	Code: G; COG: COG3684
YP_312802.1	Code: ER; COG: COG1063
YP_312804.1	Code: GEPR; COG: COG0477
YP_312806.2	Code: R; COG: COG1011
YP_312807.1	RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease
YP_312808.1	hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine
YP_312809.1	Code: KR; COG: COG0454
YP_312810.1	Code: L; COG: COG1662
YP_312812.1	affects formate dehydrogenase-N; required for the formation of active formate dehydrogenase
YP_312813.1	cytochrome b556(FDO) component; heme containing
YP_312814.1	Code: C; COG: COG0437
YP_312815.1	Code: C; COG: COG0243
YP_312816.1	affects formate dehydrogenase-N; involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth
YP_312817.1	Code: L; COG: COG1662
YP_312818.1	repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system
YP_312819.1	with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars
YP_312820.1	Code: G; COG: COG1299
YP_312821.1	with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system
YP_312822.1	Code: S; COG: COG3254
YP_312823.1	Code: G; COG: COG0235
YP_312824.1	catalyzes the formation of L-rhamnulose from L-rhamnose
YP_312825.1	catalyzes the ATP-dependent phosphorylation of rhamnulose
YP_312826.1	activates the expression of the rhaBAD operon and rhaT gene
YP_312827.1	transports L-rhamnose and L-lyxose into the cell
YP_312828.1	SodA; manganese binding; only present under aerobic conditions; destroys free radicals
YP_312829.2	transports degraded pectin products into the bacterial cell
YP_312830.2	Code: S; COG: COG2258
YP_312831.1	histidine protein kinase; part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors
YP_312832.1	response regulator in two-component regulatory system with CpxA; part of the envelope stress response system
YP_312833.2	repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates
YP_312834.1	member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers
YP_312835.1	catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis
YP_312836.1	Code: P; COG: COG1613
YP_312837.1	Code: I; COG: COG2134
YP_312838.1	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate
YP_312840.1	Code: S; COG: COG3152
YP_312841.1	Code: S; COG: COG3691
YP_312842.1	with UspC and Usp E is involved in resistance to UV radiation
YP_312843.1	Code: C; COG: COG1018
YP_312844.1	type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese
YP_312845.1	Converts glycerol and ADP to glycerol-3-phosphate and ADP
YP_312846.1	Code: G; COG: COG0580
YP_312847.1	Code: S; COG: COG3074
YP_312848.1	menaquinone biosynthesis, unknown; regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity
YP_312849.1	1,4-dihydroxy-2-naphthoate --> dimethylmenaquinone; catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate
YP_312850.1	similar to chaperones; heat shock protein involved in degradation of misfolded proteins
YP_312851.1	heat shock protein involved in degradation of misfolded proteins
YP_312852.1	Code: D; COG: COG3087
YP_312853.1	negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins
YP_312854.1	binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity
YP_312855.1	RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_312858.1	Code: L; COG: COG4584
YP_312859.1	Code: L; COG: COG1484
YP_312861.1	member of the NlpC/P60 superfamily of peptidases
YP_312862.1	when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis
YP_312863.1	catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine
YP_312864.1	homoserine dehydrogenase II; multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways
YP_312865.1	MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor
YP_312866.1	hydroperoxidase HPI(I); Code: P; COG: COG0376
YP_312867.1	Code: GER; COG: COG0697
YP_312868.1	Code: S; COG: COG3738
YP_312869.2	forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone
YP_312870.1	similar to transaldolase from Escherichia coli; many organisms have multiple copies
YP_312871.1	Code: G; COG: COG1080
YP_312872.1	FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site
YP_312873.1	Code: O; COG: COG1180
YP_312874.1	FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog
YP_312875.1	Code: K; COG: COG2207
YP_312876.1	Code: R; COG: COG2194
YP_312877.1	catalyzes the formation of oxaloacetate from phosphoenolpyruvate
YP_312878.1	catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis
YP_312879.1	catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate
YP_312880.2	catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate
YP_312881.1	catalyzes the formation of arginine from (N-L-arginino)succinate
YP_312882.1	Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA
YP_312883.2	catalyzes the conversion of NADPH to NADH
YP_312884.1	negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis
YP_312886.1	catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs
YP_312887.1	involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space
YP_312888.2	required for biosynthesis of D-glutamate and peptidoglycan; converts L-glutamate to D-glutamate, a component of peptidoglycan
YP_312889.1	catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis
YP_312890.1	catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon
YP_312891.1	catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis
YP_312893.1	duplicate of tufA; EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_312894.1	forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force
YP_312895.1	Modulates Rho-dependent transcription termination
YP_312896.1	binds directly to 23S ribosomal RNA
YP_312897.1	regulates synthesis of L1 and L11; in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA
YP_312898.1	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit
YP_312899.1	present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors
YP_312900.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_312901.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_312902.1	thiamin biosynthesis, thiazole moiety; in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center
YP_312903.2	thiamin biosynthesis, thiazole moiety; functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate
YP_312904.1	involved in thiamine biosynthesis; with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate
YP_312905.2	thiamin biosynthesis, thiazole moiety; Code: H; COG: COG0476
YP_312906.1	thiamin biosynthesis, thiazole moiety; catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate
YP_312907.1	thiamin biosynthesis, pyrimidine moiety; required for the synthesis of the hydromethylpyrimidine moiety of thiamine
YP_312908.1	binds specifically to the major sigma factor sigma 70; active in stationary phase
YP_312909.1	can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates
YP_312910.1	catalyzes the formation of coproporphyrinogen from uroporphyrinogen III
YP_312911.2	deoxyinosine 3'endoduclease; Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures
YP_312912.1	Code: S; COG: COG3068
YP_312913.1	HU-2; histone-like DNA-binding protein
YP_312915.2	Code: UNTP; COG: COG3678
YP_312916.1	Code: T; COG: COG0642
YP_312917.1	DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein
YP_312918.1	GAR synthetase; catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis
YP_312919.1	AICAR formyltransferase; IMP cyclohydrolase; involved in de novo purine biosynthesis
YP_312920.1	Code: KR; COG: COG0454
YP_312921.1	catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis
YP_312922.1	Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle
YP_312923.1	Code: C; COG: COG2224
YP_312924.1	Code: L; COG: COG1662
YP_312925.2	regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase
YP_312926.1	one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity
YP_312927.1	Code: P; COG: COG1283
YP_312928.1	alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family
YP_312929.1	Code: ER; COG: COG1063
YP_312930.1	Code: G; COG: COG3716
YP_312931.1	Code: G; COG: COG3715
YP_312932.1	Code: G; COG: COG2893
YP_312933.1	Converts D-sorbitol-dphosphate to D-fructose-6-phosphate
YP_312934.1	catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA
YP_312936.1	catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive
YP_312937.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_312942.1	Code: S; COG: COG3223
YP_312943.1	xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter
YP_312944.1	with MalKFE is involved in the transport of maltose into the cell
YP_312945.1	with MalKGE is involved in maltose transport into the cell
YP_312946.1	substrate recognition for transport and chemotaxis; functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis
YP_312947.1	with malEFG is involved in import of maltose/maltodextrin
YP_312948.1	maltose high-affinity receptor; porin involved in the transport of maltose and maltodextrins
YP_312950.1	Code: L; COG: COG3547
YP_312951.1	Code: L; COG: COG3547
YP_312952.2	catalyzes the formation of 4-hydroxybenzoate from chorismate
YP_312953.1	catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway
YP_312954.2	PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA
YP_312955.1	Code: M; COG: COG0818
YP_312956.1	Represses a number of genes involved in the response to DNA damage
YP_312957.2	Code: V; COG: COG0534
YP_312958.1	unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential
YP_312959.2	Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB
YP_312962.1	Code: J; COG: COG0042
YP_312963.2	coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia
YP_312964.1	Code: CR; COG: COG0604
YP_312965.1	unwinds double stranded DNA
YP_312966.1	converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer
YP_312967.1	catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate
YP_312968.1	Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity
YP_312969.1	Code: S; COG: COG0432
YP_312970.1	Code: S; COG: COG2315
YP_312971.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YP_312972.1	binds to single stranded DNA and PriA helcase facilitate replication restart
YP_312973.1	Code: T; COG: COG4943
YP_312974.1	regulates genes involved in response to oxidative stress
YP_312975.1	Code: L; COG: COG1662
YP_312976.1	Code: P; COG: COG0025
YP_312977.1	Code: R; COG: COG2252
YP_312978.1	Code: K; COG: COG0789
YP_312979.1	Code: L; COG: COG1662
YP_312980.1	member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake
YP_312981.1	Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA
YP_312982.1	catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552
YP_312983.1	a penta-heme cytochrome c; part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia
YP_312984.1	Fe-S centers; Code: C; COG: COG0437
YP_312985.1	Code: P; COG: COG3301
YP_312986.1	possible assembly function; with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552
YP_312987.1	part of formate-dependent nitrite reductase complex; Code: O; COG: COG3088
YP_312988.1	Code: O; COG: COG4235
YP_312989.1	carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system
YP_312990.1	Code: R; COG: COG0790
YP_312991.1	part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family
YP_312992.2	possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
YP_312993.1	with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
YP_312995.1	Code: Q; COG: COG2015
YP_312996.1	Code: G; COG: COG0698
YP_312998.1	required for the use of phosphonates and phosphite as phosphorus sources
YP_312999.1	PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role
YP_313000.1	Code: P; COG: COG3709
YP_313001.1	Code: P; COG: COG3454
YP_313002.1	Code: P; COG: COG4778
YP_313003.1	Code: P; COG: COG4107
YP_313004.1	Code: P; COG: COG3627
YP_313005.1	Code: P; COG: COG3626
YP_313006.1	Code: P; COG: COG3625
YP_313007.1	Code: P; COG: COG3624
YP_313008.1	may be involved in phosphonate uptake and biodegradation
YP_313009.1	Code: P; COG: COG3639
YP_313010.1	Code: P; COG: COG3221
YP_313011.1	Code: P; COG: COG3638
YP_313012.1	Code: P; COG: COG2824
YP_313013.1	Code: R; COG: COG0699
YP_313015.1	proline permease II; Code: GEPR; COG: COG0477
YP_313016.1	Code: T; COG: COG0642
YP_313017.1	member of 2-component regulatory system; response regulator in two-component regulatory system with BasS
YP_313018.1	with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division
YP_313019.1	Code: E; COG: COG0531
YP_313020.1	Code: K; COG: COG2207
YP_313021.1	Code: E; COG: COG1982
YP_313022.1	Code: K; COG: COG2207
YP_313023.1	Code: G; COG: COG1486
YP_313024.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_313025.1	Code: L; COG: COG1662
YP_313026.1	Code: S; COG: COG3647
YP_313027.1	fumarate hydratase Class I; anaerobic isozyme; Code: C; COG: COG1951
YP_313028.1	functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters
YP_313029.1	response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration
YP_313030.1	C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration
YP_313031.1	Code: S; COG: COG3592
YP_313032.1	Code: R; COG: COG2388
YP_313034.1	heat shock protein; class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_313035.1	Code: E; COG: COG3104
YP_313036.1	Code: L; COG: COG2801
YP_313037.1	Code: L; COG: COG2963
YP_313038.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_313039.1	Code: L; COG: COG2963
YP_313040.1	Code: L; COG: COG2801
YP_313041.1	Code: L; COG: COG3385
YP_313042.1	Code: K; COG: COG1309
YP_313043.1	copper tolerance; two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm
YP_313044.1	cytochrome c biogenesis; copper binding protein required for copper tolerance; involved in resistance toward heavy metals
YP_313045.1	functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB
YP_313046.1	aspartase; catalyzes the formation of fumarate from aspartate
YP_313047.1	Protein affecting phage T7 exclusion by the F plasmid; F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein
YP_313048.1	uncharacterized member of the APC superfamily of amino acid transporters; unknown function
YP_313049.1	10 kDa chaperone binds to Hsp60 in presence of Mg-ATP; suppressing its ATPase activity; 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring
YP_313050.1	chaperone Hsp60; peptide-dependent ATPase; heat shock protein; 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
YP_313053.1	Code: L; COG: COG1662
YP_313054.1	Code: E; COG: COG1509
YP_313055.1	EF-P; Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_313056.1	acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex
YP_313057.1	Code: S; COG: COG5510
YP_313058.1	lipocalin; lipocalin; globomycin-sensitive outer membrane lipoprotein
YP_313059.1	Code: V; COG: COG1680
YP_313060.1	in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane
YP_313061.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_313062.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_313063.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_313064.2	lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_313065.1	Code: L; COG: COG1662
YP_313066.1	Code: M; COG: COG3264
YP_313067.1	catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine
YP_313068.2	EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity
YP_313069.2	3'-5' exoribonuclease specific for small oligoribonuclotides
YP_313070.1	Code: C; COG: COG1600
YP_313071.1	Code: G; COG: COG0063
YP_313072.1	possibly involved in cell wall synthesis
YP_313073.1	a murein hydrolase; Code: M; COG: COG0860
YP_313074.1	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
YP_313075.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_313076.1	Stimulates the elongation of poly(A) tails
YP_313077.1	involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein
YP_313078.1	with HflC inhibits proteolysis of lambda cII protein by FtsH
YP_313079.1	with HflK inhibits proteolysis of lambda cII protein by FtsH
YP_313080.1	Code: S; COG: COG3242
YP_313081.1	catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis
YP_313082.1	negatively regulates the transcription of genes upregulated by nitrosative stress
YP_313083.2	3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs
YP_313084.1	Specifically methylates the ribose of guanosine 2251 in 23S rRNA
YP_313085.1	Code: L; COG: COG1662
YP_313086.1	Code: E; COG: COG0754
YP_313087.1	catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA
YP_313089.2	in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility
YP_313090.1	YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo
YP_313091.1	negative regulator of ulaG and ulaABCDEF
YP_313092.1	Code: R; COG: COG2220
YP_313093.1	involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_313094.1	involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_313095.1	catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization
YP_313096.1	UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway
YP_313097.1	catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
YP_313098.1	Code: S; COG: COG3477
YP_313100.1	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21
YP_313101.1	binds single-stranded DNA at the primosome assembly site
YP_313102.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_313103.1	in Escherichia coli this protein is wrapped around the base of the L1 stalk
YP_313104.1	Code: G; COG: COG1638
YP_313105.1	Code: L; COG: COG1662
YP_313106.1	Code: K; COG: COG1309
YP_313107.1	Code: M; COG: COG3061
YP_313108.1	involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine
YP_313109.1	Involved in anaerobic NO protection and iron metabolism
YP_313110.1	Code: GER; COG: COG0697
YP_313111.1	Code: MG; COG: COG0702
YP_313112.1	Code: K; COG: COG1733
YP_313113.1	periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate
YP_313114.1	affects pool of 3'-phosphoadenosine-5'-phosphosulfate in pathway of sulfite synthesis; catalyzes the formation of AMP from adenosine-3',5'-bisphosphate
YP_313116.1	Code: R; COG: COG3054
YP_313118.1	Code: R; COG: COG1253
YP_313119.1	this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress
YP_313120.1	Code: M; COG: COG0729
YP_313121.1	Code: S; COG: COG2911
YP_313122.1	Code: S; COG: COG2105
YP_313123.1	catalyzes the hydrolysis of pyrophosphate to phosphate
YP_313124.1	Code: G; COG: COG1879
YP_313125.1	Code: G; COG: COG1129
YP_313126.1	Code: G; COG: COG1172
YP_313127.1	membrane component of a  sugar ABC transporter system
YP_313128.1	catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate
YP_313129.1	Code: M; COG: COG0773
YP_313130.1	Code: S; COG: COG3028
YP_313131.1	maturation of antibiotic MccB17, see tld genes; protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD
YP_313132.1	Code: C; COG: COG3783
YP_313133.1	activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions
YP_313134.1	Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates
YP_313135.1	Code: G; COG: COG0366
YP_313136.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_313137.1	regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon
YP_313138.1	P-type ATPase involved in magnesium influx
YP_313139.1	Code: J; COG: COG0251
YP_313140.1	involved in the allosteric regulation of aspartate carbamoyltransferase
YP_313141.1	catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis
YP_313143.1	Code: J; COG: COG0251
YP_313144.1	Code: IQR; COG: COG1028
YP_313147.1	Code: L; COG: COG1662
YP_313148.1	Code: L; COG: COG1662
YP_313149.1	catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.
YP_313150.1	Code: S; COG: COG3076
YP_313151.1	Code: KR; COG: COG0454
YP_313152.1	Code: L; COG: COG1662
YP_313153.1	Code: L; COG: COG4584
YP_313154.1	Code: L; COG: COG1484
YP_313155.1	Code: S; COG: COG4269
YP_313156.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_313157.1	binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB
YP_313158.1	catalyzes the removal of N-terminal amino acids preferably leucine from various peptides
YP_313159.1	Code: R; COG: COG0795
YP_313160.1	Code: R; COG: COG0795
YP_313161.1	Code: R; COG: COG0433
YP_313162.1	Code: K; COG: COG1609
YP_313163.1	Code: GE; COG: COG2610
YP_313164.1	Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate
YP_313165.1	NAD-binding
YP_313166.1	thermosensitive glucokinase; Code: G; COG: COG3265
YP_313167.1	Code: R; COG: COG1064
YP_313168.1	Code: L; COG: COG2801
YP_313169.1	Code: L; COG: COG2963
YP_313170.1	Code: L; COG: COG2801
YP_313171.1	Part of the FecBCDE citrate-dependent iron (III) transport system
YP_313172.1	Ferric citrate binds FecA and is transported across the outer membrane while transmits a signal across the cytoplasmic membrane protein FecR. FecR transmits a signal across the membrane and activates the cytoplasmic FecI that directs the RNA polymerase to express the fecABCDE operon (which encodes the ferric citrate outer membrane receptor and the ferric citrate ABC transporter), as well as fecIR. FecD is one of two (along with FecC) integral membrane protein components of the iron dicitrate ABC transporter.
YP_313173.1	part of the FecBCDE citrate-dependent iron (III) transport system
YP_313174.1	part of the ABC transporter involved in the uptake of citrate-dependent Fe(3+)
YP_313175.1	citrate-dependent iron transport; Code: P; COG: COG4772
YP_313176.1	with FecA forms the FecAR signal transduction system; ferric citrate binds FecA and transmits a signal across the outer membrane to FecR. FecR transmits a signal across the cytoplasmic membrane and activates the sigma 70 protein FecI that directs the RNA polymerase to express the fecABCDE operon
YP_313177.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor regulates the genes for iron dicitrate transport
YP_313178.1	Code: L; COG: COG3677
YP_313179.1	Code: L; COG: COG1662
YP_313181.1	Code: L; COG: COG1662
YP_313182.1	Code: L; COG: COG1662
YP_313183.1	Code: L; COG: COG2801
YP_313184.1	Code: S; COG: COG3055
YP_313186.1	Code: L; COG: COG3335
YP_313187.1	Code: L; COG: COG1662
YP_313188.1	catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate
YP_313189.1	Code: G; COG: COG0246
YP_313190.1	regulates the expression of uxuBA
YP_313192.1	Code: L; COG: COG1662
YP_313194.1	Code: L; COG: COG3547
YP_313196.1	Code: R; COG: COG0523
YP_313197.1	Code: S; COG: COG2879
YP_313198.1	Code: T; COG: COG1966
YP_313199.1	Code: R; COG: COG1853
YP_313200.1	Code: Q; COG: COG2368
YP_313201.1	Code: L; COG: COG2801
YP_313202.1	Code: L; COG: COG2963
YP_313203.1	Code: GEPR; COG: COG0477
YP_313204.1	Code: G; COG: COG3836
YP_313205.1	Code: Q; COG: COG3971
YP_313206.1	Code: E; COG: COG3232
YP_313207.1	Code: S; COG: COG3384
YP_313208.1	Code: C; COG: COG1012
YP_313209.1	Code: Q; COG: COG0179
YP_313210.1	Code: K; COG: COG1846
YP_313211.1	Code: K; COG: COG1802
YP_313212.1	Code: ER; COG: COG1063
YP_313213.2	catalyzes the transfer of phosphoglycerol to the glucan backbone
YP_313215.1	acts to load the DnaB helicase onto the initiation site during DNA replication
YP_313216.1	DNA biosynthesis; This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'
YP_313217.2	Code: S; COG: COG3610
YP_313218.1	Code: S; COG: COG2966
YP_313219.1	Code: L; COG: COG1662
YP_313220.1	Code: L; COG: COG1662
YP_313221.2	regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin
YP_313222.1	Code: R; COG: COG4114
YP_313224.1	16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit
YP_313225.1	with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB
YP_313226.1	alanine acetyltransferase that specifically acetylates ribosomal protein S18
YP_313227.1	manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily
YP_313228.1	stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein
YP_313229.1	Code: R; COG: COG2823
YP_313230.1	Code: S; COG: COG5487
YP_313231.1	Code: R; COG: COG4667
YP_313232.1	Code: L; COG: COG0084
YP_313233.1	Code: O; COG: COG1180
YP_313235.1	catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate
YP_313236.1	Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
YP_313237.1	catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose
YP_313238.1	catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate
YP_313239.1	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins
YP_313240.1	Code: R; COG: COG3726
YP_313241.1	catalyzes the formation of serine from O-phosphoserine
YP_313242.1	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents
YP_313243.2	catalyzes the formation of NAD(+) from nicotinamide ribonucleotide
YP_313244.1	ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence
YP_313245.2	catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan
YP_313246.1	When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription
YP_313247.2	pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog
YP_313248.1	catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate
YP_313249.1	Code: K; COG: COG2207
YP_313250.1	Code: S; COG: COG3045
YP_313251.1	response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation
YP_313252.1	alternative sensor for pho regulon; part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation
YP_313253.1	Code: V; COG: COG4452
YP_313254.1	Code: TK; COG: COG0745
YP_313256.1	member of the SPOUT superfamily of methyltransferases
YP_313259.1	protein secreted by the Mxi-Spa secretion machinery
YP_313260.1	periplasmic phosphatase, apyrase, ATP diphosphohydrolase
YP_313263.1	probably secreted by the Mxi-Spa secretion machinery
YP_313264.1	secreted by the Mxi-Spa secretion machinery
YP_313277.1	secreted by the Mxi-Spa secretion machinery
YP_313279.1	probably secreted by the Mxi-Spa secretion machinery
YP_313296.1	member of the AraC family of transcriptional activators; required for transcription of virB and icsA
YP_313299.1	secreted by the Mxi-Spa secretion machinery
YP_313304.1	secreted by the Mxi-Spa secretion machinery
YP_313305.1	SenA; probably secreted by the Mxi-Spa secretion machinery
YP_313313.1	probably secreted by the Mxi-Spa machinery
YP_313314.1	probably secreted by the Mxi-Spa machinery
YP_313320.1	probably secreted by the Mxi-Spa secretion machinery
YP_313327.1	probably secreted by the Mxi-Spa secretion machinery
YP_313334.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_313335.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_313339.1	invasion plasmid antigen
YP_313340.1	transcriptional activator required for tanscription of the ipa, mxi, and spa operons
YP_313341.1	putative acyl carrier protein
YP_313342.1	secreted by the Mxi-Spa machinery; modulates entry of bacteria into epithelial cells
YP_313343.1	secreted by the Mxi-Spa machinery; required for entry of bacteria into epithelial cells
YP_313344.1	secreted by the Mxi-Spa secretion machinery; required for entry into epithelial cells
YP_313345.1	secreted by the Mxi-Spa secretion machinery; required for entry into epithelial cells
YP_313346.1	cytoplasmic chaperone for IpaB and IpaC
YP_313347.1	secreted by the Mxi-Spa machinery
YP_313348.1	similar to IpgE; putative chaperone
YP_313349.1	invasion protein
YP_313350.1	secreted by the Mxi-Spa machinery; modulates entry of bacteria into epithelial cells
YP_313351.1	cytoplasmic chaperone for IpgD
YP_313352.1	periplasmic protein; similar to the catalytic site of lyzozymes
YP_313353.1	component of the Mxi-Spa secretion machinery, contains one transmembrane segment
YP_313354.1	component of the Mxi-Spa secretion machinery
YP_313355.1	component of the Mxi-Spa secretion machinery
YP_313356.1	lipoprotein, component of the Mxi-Spa secretion machinery
YP_313357.1	putative component of the Mxi-Spa secretion machinery
YP_313358.1	putative component of the Mxi-Spa secretion machinery
YP_313359.1	secreted by and putative component of the Mxi-Spa secretion machinery
YP_313360.1	lipoprotein; component of the Mxi-Spa secretion machinery
YP_313361.1	similar to transcriptional activators of the AraC family
YP_313362.1	outermembrane protein of the secretin family; component of the Mxi-Spa secretion machinery
YP_313363.1	secreted by and putative component of the Mxi-Spa secretion machinery; similar to YopN (secreted by the type III secretion machinery of Yersinia enterocoltica)
YP_313364.1	innermembrane protein; component of the Mxi-Spa secretion machinery
YP_313365.1	putative component of the Mxi-Spa secretion machinery
YP_313366.1	component of the Mxi-Spa secretion machinery; putative ATPase; Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase
YP_313367.1	component of the Mxi-Spa secretion machinery
YP_313368.1	secreted by and component of the Mxi-Spa machinery
YP_313369.1	component of the Mxi-Spa secretion machinery
YP_313370.1	component of the Mxi-Spa secretion machinery; part of a type III secretory system probably involved in invasion into eukaryotic cells
YP_001449233.1	component of the Mxi-Spa secretion machinery
YP_313371.1	component of the Mxi-Spa secretion machinery
YP_313372.1	component of the Mxi-Spa secretion machinery; Required for surface presentation of invasion plasmid antigens; required for invasion and for secretion of the three ipa proteins
YP_313397.1	secreted by the Mxi-Spa secretion machinery
YP_313398.1	outermembrane protein exposed to the bacterial surface by a C-terminal autotransporter domain and involved in the movement of intracellular bacteria by binding to N-WASP
YP_313402.1	probable periplasmic UDP-sugar hydrolase; catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides
YP_313408.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_313409.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_313422.1	secreted by the Mxi-Spa secretion machinery
YP_313425.1	secreted by the Mxi-Spa secretion machinery
YP_313436.1	required for proper localization of IcsA (VirG) at the surface of bacteria
YP_313437.1	probable lipid A transacetylase; Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA
YP_313445.1	type IV secretion system coupling protein; similar to F plasmid TraD
YP_313447.1	cleaves origin of transfer and unwinds; oriT relaxase
YP_313451.1	putative fertility inhibition protein
YP_313458.1	RepA
YP_313465.1	secreted by the Mxi-Spa secretion machinery
YP_313494.1	outermembrane protease of the OmpP family; involved in cleavage of surface exposed IcsA; outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA
YP_001139952.1	tetracycline resistance repressor protein
YP_001139953.1	tetracycline resistance protein A
YP_001139954.1	dihydropteroate synthase type II
YP_001139955.1	streptomycin resistance protein A
YP_001139956.1	streptomycin resistance protein B
YP_001139962.1	plasmid mobilization protein A
YP_001139965.1	replication protein