-- dump date   	20140620_065715
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1117647000001	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1117647000002	Peptidase family M23; Region: Peptidase_M23; pfam01551
1117647000003	Uncharacterized conserved protein [Function unknown]; Region: COG2835
1117647000004	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1117647000005	nucleotide binding site/active site [active]
1117647000006	HIT family signature motif; other site
1117647000007	catalytic residue [active]
1117647000008	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1117647000009	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1117647000010	motif 1; other site
1117647000011	active site
1117647000012	motif 2; other site
1117647000013	motif 3; other site
1117647000014	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1117647000015	DHHA1 domain; Region: DHHA1; pfam02272
1117647000016	aspartate kinase; Reviewed; Region: PRK06635
1117647000017	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1117647000018	putative nucleotide binding site [chemical binding]; other site
1117647000019	putative catalytic residues [active]
1117647000020	putative Mg ion binding site [ion binding]; other site
1117647000021	putative aspartate binding site [chemical binding]; other site
1117647000022	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1117647000023	putative allosteric regulatory site; other site
1117647000024	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1117647000025	putative allosteric regulatory residue; other site
1117647000026	carbon storage regulator; Provisional; Region: PRK01712
1117647000027	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1117647000028	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1117647000029	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1117647000030	PBP superfamily domain; Region: PBP_like_2; cl17296
1117647000031	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1117647000032	dimerization interface [polypeptide binding]; other site
1117647000033	putative DNA binding site [nucleotide binding]; other site
1117647000034	putative Zn2+ binding site [ion binding]; other site
1117647000035	Predicted permeases [General function prediction only]; Region: COG0701
1117647000036	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1117647000037	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1117647000038	DNA-binding site [nucleotide binding]; DNA binding site
1117647000039	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1117647000040	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647000041	homodimer interface [polypeptide binding]; other site
1117647000042	catalytic residue [active]
1117647000043	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
1117647000044	EamA-like transporter family; Region: EamA; pfam00892
1117647000045	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
1117647000046	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1117647000047	active site
1117647000048	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1117647000049	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117647000050	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
1117647000051	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1117647000052	active site
1117647000053	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1117647000054	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1117647000055	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1117647000056	GTP/Mg2+ binding site [chemical binding]; other site
1117647000057	G4 box; other site
1117647000058	G5 box; other site
1117647000059	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1117647000060	G1 box; other site
1117647000061	G1 box; other site
1117647000062	GTP/Mg2+ binding site [chemical binding]; other site
1117647000063	Switch I region; other site
1117647000064	G2 box; other site
1117647000065	G2 box; other site
1117647000066	G3 box; other site
1117647000067	G3 box; other site
1117647000068	Switch II region; other site
1117647000069	Switch II region; other site
1117647000070	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
1117647000071	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1117647000072	CoA binding domain; Region: CoA_binding; smart00881
1117647000073	CoA-ligase; Region: Ligase_CoA; pfam00549
1117647000074	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1117647000075	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1117647000076	CoA-ligase; Region: Ligase_CoA; pfam00549
1117647000077	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
1117647000078	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1117647000079	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1117647000080	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1117647000081	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1117647000082	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1117647000083	E3 interaction surface; other site
1117647000084	lipoyl attachment site [posttranslational modification]; other site
1117647000085	e3 binding domain; Region: E3_binding; pfam02817
1117647000086	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1117647000087	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1117647000088	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1117647000089	TPP-binding site [chemical binding]; other site
1117647000090	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1117647000091	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1117647000092	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1117647000093	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675
1117647000094	L-aspartate oxidase; Provisional; Region: PRK06175
1117647000095	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1117647000096	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
1117647000097	SdhC subunit interface [polypeptide binding]; other site
1117647000098	proximal heme binding site [chemical binding]; other site
1117647000099	cardiolipin binding site; other site
1117647000100	Iron-sulfur protein interface; other site
1117647000101	proximal quinone binding site [chemical binding]; other site
1117647000102	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
1117647000103	Iron-sulfur protein interface; other site
1117647000104	proximal quinone binding site [chemical binding]; other site
1117647000105	SdhD (CybS) interface [polypeptide binding]; other site
1117647000106	proximal heme binding site [chemical binding]; other site
1117647000107	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1117647000108	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1117647000109	dimer interface [polypeptide binding]; other site
1117647000110	active site
1117647000111	citrylCoA binding site [chemical binding]; other site
1117647000112	NADH binding [chemical binding]; other site
1117647000113	cationic pore residues; other site
1117647000114	oxalacetate/citrate binding site [chemical binding]; other site
1117647000115	coenzyme A binding site [chemical binding]; other site
1117647000116	catalytic triad [active]
1117647000117	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1117647000118	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1117647000119	active site residue [active]
1117647000120	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1117647000121	active site residue [active]
1117647000122	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1117647000123	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1117647000124	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
1117647000125	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117647000126	Walker A/P-loop; other site
1117647000127	ATP binding site [chemical binding]; other site
1117647000128	Q-loop/lid; other site
1117647000129	ABC transporter signature motif; other site
1117647000130	Walker B; other site
1117647000131	D-loop; other site
1117647000132	H-loop/switch region; other site
1117647000133	heme exporter protein CcmB; Region: ccmB; TIGR01190
1117647000134	heme exporter protein CcmC; Region: ccmC; TIGR01191
1117647000135	Heme exporter protein D (CcmD); Region: CcmD; cl11475
1117647000136	CcmE; Region: CcmE; pfam03100
1117647000137	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
1117647000138	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
1117647000139	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
1117647000140	catalytic residues [active]
1117647000141	central insert; other site
1117647000142	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397
1117647000143	Chitin binding domain; Region: Chitin_bind_3; cl03871
1117647000144	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
1117647000145	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1117647000146	Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046
1117647000147	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1117647000148	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1117647000149	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1117647000150	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1117647000151	putative active site pocket [active]
1117647000152	dimerization interface [polypeptide binding]; other site
1117647000153	putative catalytic residue [active]
1117647000154	PGAP1-like protein; Region: PGAP1; pfam07819
1117647000155	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1117647000156	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1117647000157	Catalytic site [active]
1117647000158	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
1117647000159	TPR repeat; Region: TPR_11; pfam13414
1117647000160	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647000161	binding surface
1117647000162	TPR motif; other site
1117647000163	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1117647000164	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1117647000165	Walker A/P-loop; other site
1117647000166	ATP binding site [chemical binding]; other site
1117647000167	Q-loop/lid; other site
1117647000168	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
1117647000169	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1117647000170	ABC transporter signature motif; other site
1117647000171	Walker B; other site
1117647000172	D-loop; other site
1117647000173	H-loop/switch region; other site
1117647000174	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
1117647000175	FtsZ protein binding site [polypeptide binding]; other site
1117647000176	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1117647000177	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1117647000178	nucleotide binding pocket [chemical binding]; other site
1117647000179	K-X-D-G motif; other site
1117647000180	catalytic site [active]
1117647000181	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1117647000182	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1117647000183	Helix-hairpin-helix motif; Region: HHH; pfam00633
1117647000184	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1117647000185	Dimer interface [polypeptide binding]; other site
1117647000186	BRCT sequence motif; other site
1117647000187	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1117647000188	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1117647000189	catalytic residue [active]
1117647000190	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1117647000191	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117647000192	active site
1117647000193	motif I; other site
1117647000194	motif II; other site
1117647000195	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1117647000196	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1117647000197	Helix-turn-helix domain; Region: HTH_18; pfam12833
1117647000198	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1117647000199	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1117647000200	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1117647000201	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
1117647000202	FAD binding site [chemical binding]; other site
1117647000203	substrate binding site [chemical binding]; other site
1117647000204	catalytic residues [active]
1117647000205	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1117647000206	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1117647000207	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677
1117647000208	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1117647000209	acyl-activating enzyme (AAE) consensus motif; other site
1117647000210	putative AMP binding site [chemical binding]; other site
1117647000211	putative active site [active]
1117647000212	putative CoA binding site [chemical binding]; other site
1117647000213	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1117647000214	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
1117647000215	active site
1117647000216	nucleophile elbow; other site
1117647000217	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
1117647000218	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647000219	active site
1117647000220	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
1117647000221	phosphorylation site [posttranslational modification]
1117647000222	intermolecular recognition site; other site
1117647000223	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647000224	active site
1117647000225	phosphorylation site [posttranslational modification]
1117647000226	intermolecular recognition site; other site
1117647000227	dimerization interface [polypeptide binding]; other site
1117647000228	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647000229	metal binding site [ion binding]; metal-binding site
1117647000230	active site
1117647000231	I-site; other site
1117647000232	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1117647000233	anti sigma factor interaction site; other site
1117647000234	regulatory phosphorylation site [posttranslational modification]; other site
1117647000235	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647000236	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647000237	active site
1117647000238	phosphorylation site [posttranslational modification]
1117647000239	intermolecular recognition site; other site
1117647000240	dimerization interface [polypeptide binding]; other site
1117647000241	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1117647000242	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1117647000243	putative binding surface; other site
1117647000244	active site
1117647000245	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1117647000246	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647000247	ATP binding site [chemical binding]; other site
1117647000248	Mg2+ binding site [ion binding]; other site
1117647000249	G-X-G motif; other site
1117647000250	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1117647000251	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
1117647000252	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1117647000253	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1117647000254	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1117647000255	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1117647000256	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1117647000257	dimer interface [polypeptide binding]; other site
1117647000258	putative CheW interface [polypeptide binding]; other site
1117647000259	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1117647000260	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1117647000261	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1117647000262	CheD chemotactic sensory transduction; Region: CheD; cl00810
1117647000263	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1117647000264	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647000265	active site
1117647000266	phosphorylation site [posttranslational modification]
1117647000267	intermolecular recognition site; other site
1117647000268	dimerization interface [polypeptide binding]; other site
1117647000269	CheB methylesterase; Region: CheB_methylest; pfam01339
1117647000270	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1117647000271	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1117647000272	substrate binding pocket [chemical binding]; other site
1117647000273	membrane-bound complex binding site; other site
1117647000274	hinge residues; other site
1117647000275	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647000276	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647000277	metal binding site [ion binding]; metal-binding site
1117647000278	active site
1117647000279	I-site; other site
1117647000280	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
1117647000281	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
1117647000282	substrate binding site [chemical binding]; other site
1117647000283	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
1117647000284	substrate binding site [chemical binding]; other site
1117647000285	ligand binding site [chemical binding]; other site
1117647000286	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
1117647000287	active site
1117647000288	dinuclear metal binding site [ion binding]; other site
1117647000289	dimerization interface [polypeptide binding]; other site
1117647000290	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647000291	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647000292	active site
1117647000293	phosphorylation site [posttranslational modification]
1117647000294	intermolecular recognition site; other site
1117647000295	dimerization interface [polypeptide binding]; other site
1117647000296	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1117647000297	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1117647000298	putative active site [active]
1117647000299	putative metal binding site [ion binding]; other site
1117647000300	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1117647000301	substrate binding site [chemical binding]; other site
1117647000302	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1117647000303	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1117647000304	active site
1117647000305	HIGH motif; other site
1117647000306	nucleotide binding site [chemical binding]; other site
1117647000307	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1117647000308	KMSKS motif; other site
1117647000309	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
1117647000310	tRNA binding surface [nucleotide binding]; other site
1117647000311	anticodon binding site; other site
1117647000312	outer membrane porin, OprD family; Region: OprD; pfam03573
1117647000313	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1117647000314	dimer interface [polypeptide binding]; other site
1117647000315	active site
1117647000316	Schiff base residues; other site
1117647000317	Protein of unknown function (DUF3012); Region: DUF3012; pfam11216
1117647000318	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
1117647000319	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
1117647000320	30S subunit binding site; other site
1117647000321	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1117647000322	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1117647000323	putative dimer interface [polypeptide binding]; other site
1117647000324	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1117647000325	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1117647000326	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1117647000327	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
1117647000328	conserved cys residue [active]
1117647000329	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1117647000330	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1117647000331	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
1117647000332	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1117647000333	active site
1117647000334	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
1117647000335	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1117647000336	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117647000337	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1117647000338	dimerization interface [polypeptide binding]; other site
1117647000339	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1117647000340	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1117647000341	substrate binding site [chemical binding]; other site
1117647000342	ligand binding site [chemical binding]; other site
1117647000343	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1117647000344	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1117647000345	substrate binding site [chemical binding]; other site
1117647000346	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1117647000347	tartrate dehydrogenase; Region: TTC; TIGR02089
1117647000348	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
1117647000349	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1117647000350	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1117647000351	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
1117647000352	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1117647000353	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1117647000354	dimerization interface 3.5A [polypeptide binding]; other site
1117647000355	active site
1117647000356	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1117647000357	active site
1117647000358	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1117647000359	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1117647000360	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647000361	catalytic residue [active]
1117647000362	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1117647000363	substrate binding site [chemical binding]; other site
1117647000364	active site
1117647000365	catalytic residues [active]
1117647000366	heterodimer interface [polypeptide binding]; other site
1117647000367	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1117647000368	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1117647000369	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
1117647000370	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1117647000371	Sporulation related domain; Region: SPOR; pfam05036
1117647000372	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1117647000373	Colicin V production protein; Region: Colicin_V; cl00567
1117647000374	amidophosphoribosyltransferase; Provisional; Region: PRK09246
1117647000375	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1117647000376	tetramer interface [polypeptide binding]; other site
1117647000377	active site
1117647000378	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1117647000379	active site
1117647000380	MoxR-like ATPases [General function prediction only]; Region: COG0714
1117647000381	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647000382	Walker A motif; other site
1117647000383	ATP binding site [chemical binding]; other site
1117647000384	Walker B motif; other site
1117647000385	arginine finger; other site
1117647000386	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1117647000387	Protein of unknown function DUF58; Region: DUF58; pfam01882
1117647000388	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
1117647000389	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1117647000390	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1117647000391	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1117647000392	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
1117647000393	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1117647000394	Rossmann-like domain; Region: Rossmann-like; pfam10727
1117647000395	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
1117647000396	FOG: CBS domain [General function prediction only]; Region: COG0517
1117647000397	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629
1117647000398	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
1117647000399	active site
1117647000400	hydrophilic channel; other site
1117647000401	dimerization interface [polypeptide binding]; other site
1117647000402	catalytic residues [active]
1117647000403	active site lid [active]
1117647000404	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1117647000405	active site
1117647000406	YciI-like protein; Reviewed; Region: PRK11370
1117647000407	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1117647000408	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
1117647000409	active site
1117647000410	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1117647000411	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1117647000412	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1117647000413	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
1117647000414	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1117647000415	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1117647000416	RNA binding surface [nucleotide binding]; other site
1117647000417	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
1117647000418	probable active site [active]
1117647000419	YaeQ protein; Region: YaeQ; pfam07152
1117647000420	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647000421	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647000422	metal binding site [ion binding]; metal-binding site
1117647000423	active site
1117647000424	I-site; other site
1117647000425	sensory histidine kinase CreC; Provisional; Region: PRK11100
1117647000426	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1117647000427	dimerization interface [polypeptide binding]; other site
1117647000428	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647000429	dimer interface [polypeptide binding]; other site
1117647000430	phosphorylation site [posttranslational modification]
1117647000431	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647000432	ATP binding site [chemical binding]; other site
1117647000433	Mg2+ binding site [ion binding]; other site
1117647000434	G-X-G motif; other site
1117647000435	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647000436	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1117647000437	active site
1117647000438	phosphorylation site [posttranslational modification]
1117647000439	intermolecular recognition site; other site
1117647000440	dimerization interface [polypeptide binding]; other site
1117647000441	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1117647000442	DNA binding site [nucleotide binding]
1117647000443	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
1117647000444	dimer interface [polypeptide binding]; other site
1117647000445	AbgT putative transporter family; Region: ABG_transport; pfam03806
1117647000446	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
1117647000447	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
1117647000448	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1117647000449	ATP binding site [chemical binding]; other site
1117647000450	Mg++ binding site [ion binding]; other site
1117647000451	motif III; other site
1117647000452	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117647000453	nucleotide binding region [chemical binding]; other site
1117647000454	ATP-binding site [chemical binding]; other site
1117647000455	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1117647000456	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1117647000457	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1117647000458	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
1117647000459	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1117647000460	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117647000461	Walker A/P-loop; other site
1117647000462	ATP binding site [chemical binding]; other site
1117647000463	Q-loop/lid; other site
1117647000464	ABC transporter signature motif; other site
1117647000465	Walker B; other site
1117647000466	D-loop; other site
1117647000467	H-loop/switch region; other site
1117647000468	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
1117647000469	oxaloacetate decarboxylase; Provisional; Region: PRK14040
1117647000470	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1117647000471	active site
1117647000472	catalytic residues [active]
1117647000473	metal binding site [ion binding]; metal-binding site
1117647000474	homodimer binding site [polypeptide binding]; other site
1117647000475	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1117647000476	carboxyltransferase (CT) interaction site; other site
1117647000477	biotinylation site [posttranslational modification]; other site
1117647000478	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
1117647000479	EDD domain protein, DegV family; Region: DegV; TIGR00762
1117647000480	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1117647000481	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
1117647000482	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1117647000483	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1117647000484	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
1117647000485	putative C-terminal domain interface [polypeptide binding]; other site
1117647000486	putative GSH binding site (G-site) [chemical binding]; other site
1117647000487	putative dimer interface [polypeptide binding]; other site
1117647000488	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1117647000489	N-terminal domain interface [polypeptide binding]; other site
1117647000490	dimer interface [polypeptide binding]; other site
1117647000491	substrate binding pocket (H-site) [chemical binding]; other site
1117647000492	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1117647000493	Zn2+ binding site [ion binding]; other site
1117647000494	Mg2+ binding site [ion binding]; other site
1117647000495	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1117647000496	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1117647000497	putative DNA binding site [nucleotide binding]; other site
1117647000498	putative Zn2+ binding site [ion binding]; other site
1117647000499	AsnC family; Region: AsnC_trans_reg; pfam01037
1117647000500	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
1117647000501	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1117647000502	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1117647000503	Zn2+ binding site [ion binding]; other site
1117647000504	Mg2+ binding site [ion binding]; other site
1117647000505	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
1117647000506	DNA-J related protein; Region: DNAJ_related; pfam12339
1117647000507	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
1117647000508	HSP70 interaction site [polypeptide binding]; other site
1117647000509	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
1117647000510	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
1117647000511	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1117647000512	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
1117647000513	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1117647000514	RNA binding surface [nucleotide binding]; other site
1117647000515	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1117647000516	active site
1117647000517	uracil binding [chemical binding]; other site
1117647000518	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1117647000519	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117647000520	Bacterial transcriptional repressor; Region: TetR; pfam13972
1117647000521	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1117647000522	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
1117647000523	probable active site [active]
1117647000524	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192
1117647000525	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1117647000526	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1117647000527	homodimer interface [polypeptide binding]; other site
1117647000528	NADP binding site [chemical binding]; other site
1117647000529	substrate binding site [chemical binding]; other site
1117647000530	PAS domain; Region: PAS; smart00091
1117647000531	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1117647000532	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647000533	dimer interface [polypeptide binding]; other site
1117647000534	phosphorylation site [posttranslational modification]
1117647000535	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647000536	ATP binding site [chemical binding]; other site
1117647000537	Mg2+ binding site [ion binding]; other site
1117647000538	G-X-G motif; other site
1117647000539	TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926
1117647000540	Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111
1117647000541	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1117647000542	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
1117647000543	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1117647000544	catalytic residue [active]
1117647000545	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1117647000546	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1117647000547	ligand binding site [chemical binding]; other site
1117647000548	flexible hinge region; other site
1117647000549	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1117647000550	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1117647000551	ligand binding site [chemical binding]; other site
1117647000552	flexible hinge region; other site
1117647000553	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1117647000554	active site residue [active]
1117647000555	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
1117647000556	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
1117647000557	Protein of unknown function (DUF1315); Region: DUF1315; pfam07023
1117647000558	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
1117647000559	aminopeptidase N; Provisional; Region: pepN; PRK14015
1117647000560	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
1117647000561	active site
1117647000562	Zn binding site [ion binding]; other site
1117647000563	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
1117647000564	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
1117647000565	Pilin (bacterial filament); Region: Pilin; pfam00114
1117647000566	Helix-turn-helix domain; Region: HTH_18; pfam12833
1117647000567	HDOD domain; Region: HDOD; pfam08668
1117647000568	hypothetical protein; Provisional; Region: PRK10621
1117647000569	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1117647000570	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1117647000571	Oxygen tolerance; Region: BatD; pfam13584
1117647000572	von Willebrand factor type A domain; Region: VWA_2; pfam13519
1117647000573	metal ion-dependent adhesion site (MIDAS); other site
1117647000574	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
1117647000575	metal ion-dependent adhesion site (MIDAS); other site
1117647000576	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
1117647000577	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1117647000578	Protein of unknown function DUF58; Region: DUF58; pfam01882
1117647000579	MoxR-like ATPases [General function prediction only]; Region: COG0714
1117647000580	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647000581	Walker A motif; other site
1117647000582	ATP binding site [chemical binding]; other site
1117647000583	Walker B motif; other site
1117647000584	arginine finger; other site
1117647000585	Protein of unknown function (DUF2835); Region: DUF2835; pfam11197
1117647000586	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1117647000587	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1117647000588	quinone interaction residues [chemical binding]; other site
1117647000589	active site
1117647000590	catalytic residues [active]
1117647000591	FMN binding site [chemical binding]; other site
1117647000592	substrate binding site [chemical binding]; other site
1117647000593	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
1117647000594	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1117647000595	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1117647000596	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647000597	S-adenosylmethionine binding site [chemical binding]; other site
1117647000598	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1117647000599	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647000600	homodimer interface [polypeptide binding]; other site
1117647000601	catalytic residue [active]
1117647000602	excinuclease ABC subunit B; Provisional; Region: PRK05298
1117647000603	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117647000604	ATP binding site [chemical binding]; other site
1117647000605	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117647000606	nucleotide binding region [chemical binding]; other site
1117647000607	ATP-binding site [chemical binding]; other site
1117647000608	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1117647000609	UvrB/uvrC motif; Region: UVR; pfam02151
1117647000610	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1117647000611	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1117647000612	active site
1117647000613	ATP binding site [chemical binding]; other site
1117647000614	substrate binding site [chemical binding]; other site
1117647000615	activation loop (A-loop); other site
1117647000616	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1117647000617	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1117647000618	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1117647000619	Protein phosphatase 2C; Region: PP2C; pfam00481
1117647000620	active site
1117647000621	FHA domain; Region: FHA; pfam00498
1117647000622	phosphopeptide binding site; other site
1117647000623	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1117647000624	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1117647000625	phosphopeptide binding site; other site
1117647000626	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
1117647000627	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
1117647000628	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1117647000629	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1117647000630	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1117647000631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647000632	active site
1117647000633	phosphorylation site [posttranslational modification]
1117647000634	intermolecular recognition site; other site
1117647000635	dimerization interface [polypeptide binding]; other site
1117647000636	lytic murein transglycosylase; Provisional; Region: PRK11619
1117647000637	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1117647000638	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1117647000639	catalytic residue [active]
1117647000640	ABC transporter ATPase component; Reviewed; Region: PRK11147
1117647000641	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1117647000642	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1117647000643	ABC transporter; Region: ABC_tran_2; pfam12848
1117647000644	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1117647000645	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1117647000646	Ligand Binding Site [chemical binding]; other site
1117647000647	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1117647000648	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1117647000649	active site
1117647000650	interdomain interaction site; other site
1117647000651	putative metal-binding site [ion binding]; other site
1117647000652	nucleotide binding site [chemical binding]; other site
1117647000653	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1117647000654	domain I; other site
1117647000655	DNA binding groove [nucleotide binding]
1117647000656	phosphate binding site [ion binding]; other site
1117647000657	domain II; other site
1117647000658	domain III; other site
1117647000659	nucleotide binding site [chemical binding]; other site
1117647000660	catalytic site [active]
1117647000661	domain IV; other site
1117647000662	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1117647000663	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1117647000664	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
1117647000665	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
1117647000666	Cell division inhibitor SulA; Region: SulA; cl01880
1117647000667	LexA repressor; Validated; Region: PRK00215
1117647000668	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1117647000669	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1117647000670	Catalytic site [active]
1117647000671	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1117647000672	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1117647000673	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117647000674	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1117647000675	beta-hexosaminidase; Provisional; Region: PRK05337
1117647000676	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1117647000677	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1117647000678	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1117647000679	active site
1117647000680	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1117647000681	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1117647000682	DNA-binding site [nucleotide binding]; DNA binding site
1117647000683	RNA-binding motif; other site
1117647000684	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
1117647000685	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1117647000686	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1117647000687	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117647000688	ATP binding site [chemical binding]; other site
1117647000689	putative Mg++ binding site [ion binding]; other site
1117647000690	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117647000691	nucleotide binding region [chemical binding]; other site
1117647000692	ATP-binding site [chemical binding]; other site
1117647000693	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1117647000694	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
1117647000695	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1117647000696	E3 interaction surface; other site
1117647000697	lipoyl attachment site [posttranslational modification]; other site
1117647000698	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
1117647000699	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
1117647000700	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
1117647000701	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
1117647000702	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
1117647000703	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
1117647000704	Protein of unknown function (DUF539); Region: DUF539; cl01129
1117647000705	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
1117647000706	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1117647000707	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1117647000708	PilZ domain; Region: PilZ; pfam07238
1117647000709	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
1117647000710	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1117647000711	FtsX-like permease family; Region: FtsX; pfam02687
1117647000712	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
1117647000713	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1117647000714	Walker A/P-loop; other site
1117647000715	ATP binding site [chemical binding]; other site
1117647000716	Q-loop/lid; other site
1117647000717	ABC transporter signature motif; other site
1117647000718	Walker B; other site
1117647000719	D-loop; other site
1117647000720	H-loop/switch region; other site
1117647000721	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
1117647000722	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1117647000723	FtsX-like permease family; Region: FtsX; pfam02687
1117647000724	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
1117647000725	adenylate kinase; Reviewed; Region: adk; PRK00279
1117647000726	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1117647000727	AMP-binding site [chemical binding]; other site
1117647000728	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1117647000729	ferrochelatase; Reviewed; Region: hemH; PRK00035
1117647000730	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1117647000731	C-terminal domain interface [polypeptide binding]; other site
1117647000732	active site
1117647000733	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1117647000734	active site
1117647000735	N-terminal domain interface [polypeptide binding]; other site
1117647000736	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1117647000737	Glycoprotease family; Region: Peptidase_M22; pfam00814
1117647000738	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1117647000739	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1117647000740	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1117647000741	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1117647000742	active site
1117647000743	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1117647000744	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
1117647000745	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
1117647000746	active site
1117647000747	metal binding site [ion binding]; metal-binding site
1117647000748	Domain of unknown function (DUF3524); Region: DUF3524; pfam12038
1117647000749	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1117647000750	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1117647000751	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1117647000752	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1117647000753	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1117647000754	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1117647000755	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1117647000756	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1117647000757	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1117647000758	active site
1117647000759	HIGH motif; other site
1117647000760	dimer interface [polypeptide binding]; other site
1117647000761	KMSKS motif; other site
1117647000762	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1117647000763	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
1117647000764	inhibitor-cofactor binding pocket; inhibition site
1117647000765	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647000766	catalytic residue [active]
1117647000767	PilZ domain; Region: PilZ; pfam07238
1117647000768	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
1117647000769	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
1117647000770	Ligand Binding Site [chemical binding]; other site
1117647000771	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
1117647000772	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1117647000773	putative DNA binding site [nucleotide binding]; other site
1117647000774	putative Zn2+ binding site [ion binding]; other site
1117647000775	AsnC family; Region: AsnC_trans_reg; pfam01037
1117647000776	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1117647000777	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1117647000778	hexamer interface [polypeptide binding]; other site
1117647000779	ligand binding site [chemical binding]; other site
1117647000780	putative active site [active]
1117647000781	NAD(P) binding site [chemical binding]; other site
1117647000782	PAS domain S-box; Region: sensory_box; TIGR00229
1117647000783	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647000784	putative active site [active]
1117647000785	heme pocket [chemical binding]; other site
1117647000786	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647000787	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647000788	metal binding site [ion binding]; metal-binding site
1117647000789	active site
1117647000790	I-site; other site
1117647000791	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1117647000792	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1117647000793	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
1117647000794	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
1117647000795	Probable Catalytic site; other site
1117647000796	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
1117647000797	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1117647000798	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1117647000799	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1117647000800	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
1117647000801	Competence protein; Region: Competence; pfam03772
1117647000802	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1117647000803	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1117647000804	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1117647000805	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1117647000806	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
1117647000807	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
1117647000808	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1117647000809	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1117647000810	Ligand binding site; other site
1117647000811	oligomer interface; other site
1117647000812	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1117647000813	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1117647000814	active site
1117647000815	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
1117647000816	FAD binding domain; Region: FAD_binding_4; pfam01565
1117647000817	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1117647000818	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647000819	active site
1117647000820	phosphorylation site [posttranslational modification]
1117647000821	intermolecular recognition site; other site
1117647000822	dimerization interface [polypeptide binding]; other site
1117647000823	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1117647000824	DNA binding residues [nucleotide binding]
1117647000825	dimerization interface [polypeptide binding]; other site
1117647000826	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1117647000827	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1117647000828	GIY-YIG motif/motif A; other site
1117647000829	active site
1117647000830	catalytic site [active]
1117647000831	putative DNA binding site [nucleotide binding]; other site
1117647000832	metal binding site [ion binding]; metal-binding site
1117647000833	UvrB/uvrC motif; Region: UVR; pfam02151
1117647000834	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1117647000835	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1117647000836	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1117647000837	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
1117647000838	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1117647000839	non-specific DNA binding site [nucleotide binding]; other site
1117647000840	salt bridge; other site
1117647000841	sequence-specific DNA binding site [nucleotide binding]; other site
1117647000842	HipA N-terminal domain; Region: Couple_hipA; pfam13657
1117647000843	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
1117647000844	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1117647000845	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1117647000846	Domain of unknown function (DUF1996); Region: DUF1996; pfam09362
1117647000847	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
1117647000848	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1117647000849	substrate binding pocket [chemical binding]; other site
1117647000850	membrane-bound complex binding site; other site
1117647000851	hinge residues; other site
1117647000852	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
1117647000853	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1117647000854	DNA-binding site [nucleotide binding]; DNA binding site
1117647000855	UTRA domain; Region: UTRA; pfam07702
1117647000856	urocanate hydratase; Provisional; Region: PRK05414
1117647000857	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1117647000858	active sites [active]
1117647000859	tetramer interface [polypeptide binding]; other site
1117647000860	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1117647000861	Beta-lactamase; Region: Beta-lactamase; pfam00144
1117647000862	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1117647000863	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1117647000864	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1117647000865	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
1117647000866	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1117647000867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1117647000868	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1117647000869	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
1117647000870	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
1117647000871	PA/protease or protease-like domain interface [polypeptide binding]; other site
1117647000872	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
1117647000873	metal binding site [ion binding]; metal-binding site
1117647000874	hypothetical protein; Provisional; Region: PRK10621
1117647000875	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1117647000876	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1117647000877	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1117647000878	active site
1117647000879	catalytic site [active]
1117647000880	substrate binding site [chemical binding]; other site
1117647000881	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
1117647000882	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1117647000883	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
1117647000884	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1117647000885	metal binding triad; other site
1117647000886	Protein of unknown function (DUF1223); Region: DUF1223; cl10501
1117647000887	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1117647000888	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1117647000889	Na binding site [ion binding]; other site
1117647000890	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
1117647000891	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1117647000892	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647000893	active site
1117647000894	phosphorylation site [posttranslational modification]
1117647000895	intermolecular recognition site; other site
1117647000896	dimerization interface [polypeptide binding]; other site
1117647000897	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1117647000898	DNA binding residues [nucleotide binding]
1117647000899	dimerization interface [polypeptide binding]; other site
1117647000900	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
1117647000901	Na binding site [ion binding]; other site
1117647000902	PAS domain; Region: PAS; smart00091
1117647000903	PAS fold; Region: PAS_7; pfam12860
1117647000904	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117647000905	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647000906	dimer interface [polypeptide binding]; other site
1117647000907	phosphorylation site [posttranslational modification]
1117647000908	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647000909	ATP binding site [chemical binding]; other site
1117647000910	Mg2+ binding site [ion binding]; other site
1117647000911	G-X-G motif; other site
1117647000912	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1117647000913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647000914	active site
1117647000915	phosphorylation site [posttranslational modification]
1117647000916	intermolecular recognition site; other site
1117647000917	dimerization interface [polypeptide binding]; other site
1117647000918	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1117647000919	CoenzymeA binding site [chemical binding]; other site
1117647000920	subunit interaction site [polypeptide binding]; other site
1117647000921	PHB binding site; other site
1117647000922	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1117647000923	CoenzymeA binding site [chemical binding]; other site
1117647000924	subunit interaction site [polypeptide binding]; other site
1117647000925	PHB binding site; other site
1117647000926	heat shock protein 90; Provisional; Region: PRK05218
1117647000927	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647000928	ATP binding site [chemical binding]; other site
1117647000929	Mg2+ binding site [ion binding]; other site
1117647000930	G-X-G motif; other site
1117647000931	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1117647000932	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1117647000933	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1117647000934	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
1117647000935	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1117647000936	catalytic core [active]
1117647000937	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1117647000938	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1117647000939	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1117647000940	GTP cyclohydrolase I; Provisional; Region: PLN03044
1117647000941	homodecamer interface [polypeptide binding]; other site
1117647000942	active site
1117647000943	putative catalytic site residues [active]
1117647000944	zinc binding site [ion binding]; other site
1117647000945	GTP-CH-I/GFRP interaction surface; other site
1117647000946	HemK family putative methylases; Region: hemK_fam; TIGR00536
1117647000947	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647000948	S-adenosylmethionine binding site [chemical binding]; other site
1117647000949	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1117647000950	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1117647000951	Tetramer interface [polypeptide binding]; other site
1117647000952	active site
1117647000953	FMN-binding site [chemical binding]; other site
1117647000954	C-N hydrolase family amidase; Provisional; Region: PRK10438
1117647000955	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
1117647000956	putative active site [active]
1117647000957	catalytic triad [active]
1117647000958	dimer interface [polypeptide binding]; other site
1117647000959	multimer interface [polypeptide binding]; other site
1117647000960	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
1117647000961	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1117647000962	substrate binding site [chemical binding]; other site
1117647000963	oxyanion hole (OAH) forming residues; other site
1117647000964	trimer interface [polypeptide binding]; other site
1117647000965	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1117647000966	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1117647000967	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1117647000968	trigger factor; Provisional; Region: tig; PRK01490
1117647000969	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1117647000970	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1117647000971	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1117647000972	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1117647000973	oligomer interface [polypeptide binding]; other site
1117647000974	active site residues [active]
1117647000975	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1117647000976	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1117647000977	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647000978	Walker A motif; other site
1117647000979	ATP binding site [chemical binding]; other site
1117647000980	Walker B motif; other site
1117647000981	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1117647000982	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1117647000983	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1117647000984	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1117647000985	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647000986	Walker A motif; other site
1117647000987	ATP binding site [chemical binding]; other site
1117647000988	Walker B motif; other site
1117647000989	arginine finger; other site
1117647000990	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1117647000991	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1117647000992	IHF dimer interface [polypeptide binding]; other site
1117647000993	IHF - DNA interface [nucleotide binding]; other site
1117647000994	periplasmic folding chaperone; Provisional; Region: PRK10788
1117647000995	SurA N-terminal domain; Region: SurA_N_3; pfam13624
1117647000996	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1117647000997	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1117647000998	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1117647000999	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1117647001000	catalytic residue [active]
1117647001001	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1117647001002	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1117647001003	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1117647001004	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1117647001005	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
1117647001006	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1117647001007	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1117647001008	RNA/DNA hybrid binding site [nucleotide binding]; other site
1117647001009	active site
1117647001010	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
1117647001011	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
1117647001012	active site
1117647001013	catalytic site [active]
1117647001014	substrate binding site [chemical binding]; other site
1117647001015	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1117647001016	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1117647001017	TAP-like protein; Region: Abhydrolase_4; pfam08386
1117647001018	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647001019	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647001020	metal binding site [ion binding]; metal-binding site
1117647001021	active site
1117647001022	I-site; other site
1117647001023	Cell division inhibitor SulA; Region: SulA; cl01880
1117647001024	DNA Polymerase Y-family; Region: PolY_like; cd03468
1117647001025	active site
1117647001026	DNA binding site [nucleotide binding]
1117647001027	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
1117647001028	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
1117647001029	putative active site [active]
1117647001030	putative PHP Thumb interface [polypeptide binding]; other site
1117647001031	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1117647001032	generic binding surface II; other site
1117647001033	generic binding surface I; other site
1117647001034	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1117647001035	classical (c) SDRs; Region: SDR_c; cd05233
1117647001036	NAD(P) binding site [chemical binding]; other site
1117647001037	active site
1117647001038	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
1117647001039	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1117647001040	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1117647001041	RHS Repeat; Region: RHS_repeat; pfam05593
1117647001042	RHS Repeat; Region: RHS_repeat; pfam05593
1117647001043	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1117647001044	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
1117647001045	RHS Repeat; Region: RHS_repeat; pfam05593
1117647001046	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
1117647001047	RHS Repeat; Region: RHS_repeat; pfam05593
1117647001048	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
1117647001049	RHS protein; Region: RHS; pfam03527
1117647001050	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1117647001051	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1117647001052	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1117647001053	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
1117647001054	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1117647001055	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647001056	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647001057	metal binding site [ion binding]; metal-binding site
1117647001058	active site
1117647001059	I-site; other site
1117647001060	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1117647001061	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1117647001062	active site
1117647001063	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1117647001064	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1117647001065	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1117647001066	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1117647001067	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1117647001068	carboxyltransferase (CT) interaction site; other site
1117647001069	biotinylation site [posttranslational modification]; other site
1117647001070	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1117647001071	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1117647001072	active site
1117647001073	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1117647001074	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1117647001075	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1117647001076	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
1117647001077	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1117647001078	NAD(P) binding site [chemical binding]; other site
1117647001079	substrate binding site [chemical binding]; other site
1117647001080	homotetramer interface [polypeptide binding]; other site
1117647001081	active site
1117647001082	homodimer interface [polypeptide binding]; other site
1117647001083	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
1117647001084	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1117647001085	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117647001086	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1117647001087	OmpA family; Region: OmpA; pfam00691
1117647001088	ligand binding site [chemical binding]; other site
1117647001089	BolA-like protein; Region: BolA; cl00386
1117647001090	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
1117647001091	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1117647001092	active site residue [active]
1117647001093	Putative exonuclease, RdgC; Region: RdgC; pfam04381
1117647001094	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
1117647001095	Domain of unknown function (DUF4202); Region: DUF4202; pfam13875
1117647001096	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
1117647001097	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1117647001098	ligand binding site [chemical binding]; other site
1117647001099	flexible hinge region; other site
1117647001100	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1117647001101	putative switch regulator; other site
1117647001102	non-specific DNA interactions [nucleotide binding]; other site
1117647001103	DNA binding site [nucleotide binding]
1117647001104	sequence specific DNA binding site [nucleotide binding]; other site
1117647001105	putative cAMP binding site [chemical binding]; other site
1117647001106	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1117647001107	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1117647001108	tetrameric interface [polypeptide binding]; other site
1117647001109	NAD binding site [chemical binding]; other site
1117647001110	catalytic residues [active]
1117647001111	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
1117647001112	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1117647001113	inhibitor-cofactor binding pocket; inhibition site
1117647001114	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647001115	catalytic residue [active]
1117647001116	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1117647001117	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117647001118	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1117647001119	dimerization interface [polypeptide binding]; other site
1117647001120	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1117647001121	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1117647001122	active site
1117647001123	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1117647001124	catalytic triad [active]
1117647001125	dimer interface [polypeptide binding]; other site
1117647001126	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1117647001127	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117647001128	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
1117647001129	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1117647001130	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1117647001131	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
1117647001132	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1117647001133	Ligand binding site [chemical binding]; other site
1117647001134	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1117647001135	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1117647001136	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
1117647001137	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1117647001138	ATP-dependent helicase HepA; Validated; Region: PRK04914
1117647001139	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117647001140	ATP binding site [chemical binding]; other site
1117647001141	putative Mg++ binding site [ion binding]; other site
1117647001142	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117647001143	nucleotide binding region [chemical binding]; other site
1117647001144	ATP-binding site [chemical binding]; other site
1117647001145	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1117647001146	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1117647001147	putative acyl-acceptor binding pocket; other site
1117647001148	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
1117647001149	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1117647001150	ATP binding site [chemical binding]; other site
1117647001151	Mg++ binding site [ion binding]; other site
1117647001152	motif III; other site
1117647001153	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117647001154	nucleotide binding region [chemical binding]; other site
1117647001155	ATP-binding site [chemical binding]; other site
1117647001156	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
1117647001157	putative RNA binding site [nucleotide binding]; other site
1117647001158	Domain of unknown function (DUF3806); Region: DUF3806; pfam12713
1117647001159	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
1117647001160	Nucleoid-associated protein [General function prediction only]; Region: COG3081
1117647001161	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
1117647001162	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
1117647001163	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1117647001164	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1117647001165	putative NADH binding site [chemical binding]; other site
1117647001166	putative active site [active]
1117647001167	nudix motif; other site
1117647001168	putative metal binding site [ion binding]; other site
1117647001169	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
1117647001170	putative inner membrane peptidase; Provisional; Region: PRK11778
1117647001171	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1117647001172	tandem repeat interface [polypeptide binding]; other site
1117647001173	oligomer interface [polypeptide binding]; other site
1117647001174	active site residues [active]
1117647001175	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1117647001176	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1117647001177	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
1117647001178	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
1117647001179	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1117647001180	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1117647001181	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1117647001182	MarR family; Region: MarR_2; pfam12802
1117647001183	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
1117647001184	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1117647001185	IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341
1117647001186	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1117647001187	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
1117647001188	Flagellar regulator YcgR; Region: YcgR; pfam07317
1117647001189	FlgN protein; Region: FlgN; pfam05130
1117647001190	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
1117647001191	SAF-like; Region: SAF_2; pfam13144
1117647001192	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1117647001193	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1117647001194	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1117647001195	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647001196	active site
1117647001197	phosphorylation site [posttranslational modification]
1117647001198	intermolecular recognition site; other site
1117647001199	dimerization interface [polypeptide binding]; other site
1117647001200	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1117647001201	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1117647001202	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647001203	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
1117647001204	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
1117647001205	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
1117647001206	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1117647001207	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
1117647001208	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1117647001209	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
1117647001210	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
1117647001211	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
1117647001212	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
1117647001213	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1117647001214	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
1117647001215	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1117647001216	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1117647001217	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
1117647001218	Flagellar L-ring protein; Region: FlgH; pfam02107
1117647001219	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
1117647001220	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
1117647001221	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
1117647001222	Rod binding protein; Region: Rod-binding; cl01626
1117647001223	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
1117647001224	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
1117647001225	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1117647001226	flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12717
1117647001227	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1117647001228	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1117647001229	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1117647001230	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1117647001231	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1117647001232	flagellin; Reviewed; Region: PRK08869
1117647001233	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1117647001234	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
1117647001235	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
1117647001236	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
1117647001237	Flagellar protein FliS; Region: FliS; cl00654
1117647001238	Flagellar protein FliS; Region: FliS; cl00654
1117647001239	Flagellar protein FliS; Region: FliS; cl00654
1117647001240	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1117647001241	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
1117647001242	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647001243	Walker A motif; other site
1117647001244	ATP binding site [chemical binding]; other site
1117647001245	Walker B motif; other site
1117647001246	arginine finger; other site
1117647001247	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1117647001248	PAS domain; Region: PAS; smart00091
1117647001249	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1117647001250	putative active site [active]
1117647001251	heme pocket [chemical binding]; other site
1117647001252	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647001253	dimer interface [polypeptide binding]; other site
1117647001254	phosphorylation site [posttranslational modification]
1117647001255	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647001256	ATP binding site [chemical binding]; other site
1117647001257	Mg2+ binding site [ion binding]; other site
1117647001258	G-X-G motif; other site
1117647001259	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1117647001260	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647001261	active site
1117647001262	phosphorylation site [posttranslational modification]
1117647001263	intermolecular recognition site; other site
1117647001264	dimerization interface [polypeptide binding]; other site
1117647001265	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647001266	Walker A motif; other site
1117647001267	ATP binding site [chemical binding]; other site
1117647001268	Walker B motif; other site
1117647001269	arginine finger; other site
1117647001270	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1117647001271	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
1117647001272	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
1117647001273	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
1117647001274	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1117647001275	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
1117647001276	MgtE intracellular N domain; Region: MgtE_N; smart00924
1117647001277	FliG C-terminal domain; Region: FliG_C; pfam01706
1117647001278	flagellar assembly protein H; Validated; Region: fliH; PRK05687
1117647001279	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
1117647001280	Flagellar assembly protein FliH; Region: FliH; pfam02108
1117647001281	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
1117647001282	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1117647001283	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1117647001284	Walker A motif; other site
1117647001285	ATP binding site [chemical binding]; other site
1117647001286	Walker B motif; other site
1117647001287	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1117647001288	anti sigma factor interaction site; other site
1117647001289	regulatory phosphorylation site [posttranslational modification]; other site
1117647001290	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647001291	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647001292	active site
1117647001293	phosphorylation site [posttranslational modification]
1117647001294	intermolecular recognition site; other site
1117647001295	dimerization interface [polypeptide binding]; other site
1117647001296	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1117647001297	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1117647001298	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1117647001299	putative binding surface; other site
1117647001300	active site
1117647001301	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1117647001302	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
1117647001303	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
1117647001304	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1117647001305	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
1117647001306	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
1117647001307	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
1117647001308	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
1117647001309	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
1117647001310	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
1117647001311	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
1117647001312	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1117647001313	Strictosidine synthase; Region: Str_synth; pfam03088
1117647001314	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
1117647001315	FHIPEP family; Region: FHIPEP; pfam00771
1117647001316	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
1117647001317	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1117647001318	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1117647001319	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
1117647001320	P-loop; other site
1117647001321	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
1117647001322	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117647001323	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1117647001324	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1117647001325	DNA binding residues [nucleotide binding]
1117647001326	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
1117647001327	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647001328	active site
1117647001329	phosphorylation site [posttranslational modification]
1117647001330	intermolecular recognition site; other site
1117647001331	dimerization interface [polypeptide binding]; other site
1117647001332	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
1117647001333	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1117647001334	putative binding surface; other site
1117647001335	active site
1117647001336	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1117647001337	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1117647001338	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647001339	ATP binding site [chemical binding]; other site
1117647001340	Mg2+ binding site [ion binding]; other site
1117647001341	G-X-G motif; other site
1117647001342	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1117647001343	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1117647001344	flagellar motor protein; Reviewed; Region: motC; PRK09109
1117647001345	flagellar motor protein MotD; Reviewed; Region: PRK09038
1117647001346	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1117647001347	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1117647001348	ligand binding site [chemical binding]; other site
1117647001349	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1117647001350	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1117647001351	P-loop; other site
1117647001352	Magnesium ion binding site [ion binding]; other site
1117647001353	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1117647001354	Magnesium ion binding site [ion binding]; other site
1117647001355	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
1117647001356	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1117647001357	putative CheA interaction surface; other site
1117647001358	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
1117647001359	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
1117647001360	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117647001361	NAD(P) binding site [chemical binding]; other site
1117647001362	active site
1117647001363	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1117647001364	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
1117647001365	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117647001366	motif II; other site
1117647001367	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
1117647001368	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1117647001369	active site
1117647001370	putative substrate binding pocket [chemical binding]; other site
1117647001371	DNA gyrase subunit A; Validated; Region: PRK05560
1117647001372	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1117647001373	CAP-like domain; other site
1117647001374	active site
1117647001375	primary dimer interface [polypeptide binding]; other site
1117647001376	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1117647001377	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1117647001378	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1117647001379	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1117647001380	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1117647001381	Chorismate mutase type II; Region: CM_2; cl00693
1117647001382	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
1117647001383	Prephenate dehydratase; Region: PDT; pfam00800
1117647001384	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1117647001385	putative L-Phe binding site [chemical binding]; other site
1117647001386	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1117647001387	ligand-binding site [chemical binding]; other site
1117647001388	phosphomannomutase CpsG; Provisional; Region: PRK15414
1117647001389	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1117647001390	active site
1117647001391	substrate binding site [chemical binding]; other site
1117647001392	metal binding site [ion binding]; metal-binding site
1117647001393	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1117647001394	active site
1117647001395	tetramer interface; other site
1117647001396	cytidylate kinase; Provisional; Region: cmk; PRK00023
1117647001397	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1117647001398	CMP-binding site; other site
1117647001399	The sites determining sugar specificity; other site
1117647001400	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
1117647001401	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1117647001402	RNA binding site [nucleotide binding]; other site
1117647001403	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1117647001404	RNA binding site [nucleotide binding]; other site
1117647001405	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1117647001406	RNA binding site [nucleotide binding]; other site
1117647001407	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1117647001408	RNA binding site [nucleotide binding]; other site
1117647001409	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1117647001410	RNA binding site [nucleotide binding]; other site
1117647001411	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
1117647001412	RNA binding site [nucleotide binding]; other site
1117647001413	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1117647001414	IHF dimer interface [polypeptide binding]; other site
1117647001415	IHF - DNA interface [nucleotide binding]; other site
1117647001416	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
1117647001417	tetratricopeptide repeat protein; Provisional; Region: PRK11788
1117647001418	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1117647001419	active site
1117647001420	dimer interface [polypeptide binding]; other site
1117647001421	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1117647001422	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1117647001423	Active Sites [active]
1117647001424	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
1117647001425	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1117647001426	CysD dimerization site [polypeptide binding]; other site
1117647001427	G1 box; other site
1117647001428	putative GEF interaction site [polypeptide binding]; other site
1117647001429	GTP/Mg2+ binding site [chemical binding]; other site
1117647001430	Switch I region; other site
1117647001431	G2 box; other site
1117647001432	G3 box; other site
1117647001433	Switch II region; other site
1117647001434	G4 box; other site
1117647001435	G5 box; other site
1117647001436	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1117647001437	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1117647001438	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1117647001439	active site
1117647001440	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1117647001441	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
1117647001442	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
1117647001443	Ligand binding site; other site
1117647001444	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1117647001445	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1117647001446	Walker A/P-loop; other site
1117647001447	ATP binding site [chemical binding]; other site
1117647001448	Q-loop/lid; other site
1117647001449	ABC transporter signature motif; other site
1117647001450	Walker B; other site
1117647001451	D-loop; other site
1117647001452	H-loop/switch region; other site
1117647001453	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1117647001454	Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050
1117647001455	indole-3-acetate beta-glucosyltransferase; Region: PLN02152
1117647001456	Exostosin family; Region: Exostosin; pfam03016
1117647001457	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1117647001458	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1117647001459	NADP-binding site; other site
1117647001460	homotetramer interface [polypeptide binding]; other site
1117647001461	substrate binding site [chemical binding]; other site
1117647001462	homodimer interface [polypeptide binding]; other site
1117647001463	active site
1117647001464	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
1117647001465	active site
1117647001466	GDP-Mannose binding site [chemical binding]; other site
1117647001467	dimer interface [polypeptide binding]; other site
1117647001468	modified nudix motif
1117647001469	metal binding site [ion binding]; metal-binding site
1117647001470	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1117647001471	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1117647001472	Substrate binding site; other site
1117647001473	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
1117647001474	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
1117647001475	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1117647001476	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1117647001477	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1117647001478	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1117647001479	NAD binding site [chemical binding]; other site
1117647001480	substrate binding site [chemical binding]; other site
1117647001481	homodimer interface [polypeptide binding]; other site
1117647001482	active site
1117647001483	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1117647001484	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1117647001485	substrate binding site; other site
1117647001486	tetramer interface; other site
1117647001487	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
1117647001488	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1117647001489	active site
1117647001490	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1117647001491	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1117647001492	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1117647001493	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1117647001494	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1117647001495	NAD(P) binding site [chemical binding]; other site
1117647001496	homodimer interface [polypeptide binding]; other site
1117647001497	substrate binding site [chemical binding]; other site
1117647001498	active site
1117647001499	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1117647001500	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
1117647001501	Mg++ binding site [ion binding]; other site
1117647001502	putative catalytic motif [active]
1117647001503	putative substrate binding site [chemical binding]; other site
1117647001504	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1117647001505	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117647001506	NAD(P) binding site [chemical binding]; other site
1117647001507	active site
1117647001508	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1117647001509	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1117647001510	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1117647001511	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1117647001512	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1117647001513	active site
1117647001514	dimer interface [polypeptide binding]; other site
1117647001515	motif 1; other site
1117647001516	motif 2; other site
1117647001517	motif 3; other site
1117647001518	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1117647001519	anticodon binding site; other site
1117647001520	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1117647001521	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1117647001522	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1117647001523	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1117647001524	23S rRNA binding site [nucleotide binding]; other site
1117647001525	L21 binding site [polypeptide binding]; other site
1117647001526	L13 binding site [polypeptide binding]; other site
1117647001527	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1117647001528	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1117647001529	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1117647001530	dimer interface [polypeptide binding]; other site
1117647001531	motif 1; other site
1117647001532	active site
1117647001533	motif 2; other site
1117647001534	motif 3; other site
1117647001535	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1117647001536	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1117647001537	putative tRNA-binding site [nucleotide binding]; other site
1117647001538	B3/4 domain; Region: B3_4; pfam03483
1117647001539	tRNA synthetase B5 domain; Region: B5; smart00874
1117647001540	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1117647001541	dimer interface [polypeptide binding]; other site
1117647001542	motif 1; other site
1117647001543	motif 3; other site
1117647001544	motif 2; other site
1117647001545	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1117647001546	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1117647001547	IHF dimer interface [polypeptide binding]; other site
1117647001548	IHF - DNA interface [nucleotide binding]; other site
1117647001549	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
1117647001550	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1117647001551	DNA binding residues [nucleotide binding]
1117647001552	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
1117647001553	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1117647001554	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1117647001555	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
1117647001556	active site
1117647001557	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
1117647001558	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
1117647001559	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
1117647001560	active site
1117647001561	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1117647001562	Chitinase C; Region: ChiC; pfam06483
1117647001563	Cellulose-binding domain, chitinase and related proteins; Region: CBD_like; cd12204
1117647001564	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1117647001565	ligand binding site [chemical binding]; other site
1117647001566	Helix-Turn-Helix DNA binding domain of putative Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR_unk; cd04787
1117647001567	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1117647001568	DNA binding residues [nucleotide binding]
1117647001569	dimer interface [polypeptide binding]; other site
1117647001570	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
1117647001571	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
1117647001572	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1117647001573	SnoaL-like domain; Region: SnoaL_3; pfam13474
1117647001574	SnoaL-like domain; Region: SnoaL_2; pfam12680
1117647001575	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1117647001576	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
1117647001577	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
1117647001578	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1117647001579	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1117647001580	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1117647001581	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1117647001582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647001583	active site
1117647001584	phosphorylation site [posttranslational modification]
1117647001585	intermolecular recognition site; other site
1117647001586	dimerization interface [polypeptide binding]; other site
1117647001587	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1117647001588	DNA binding site [nucleotide binding]
1117647001589	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1117647001590	HAMP domain; Region: HAMP; pfam00672
1117647001591	dimerization interface [polypeptide binding]; other site
1117647001592	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647001593	dimer interface [polypeptide binding]; other site
1117647001594	phosphorylation site [posttranslational modification]
1117647001595	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647001596	ATP binding site [chemical binding]; other site
1117647001597	Mg2+ binding site [ion binding]; other site
1117647001598	G-X-G motif; other site
1117647001599	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
1117647001600	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
1117647001601	DNA binding residues [nucleotide binding]
1117647001602	dimer interface [polypeptide binding]; other site
1117647001603	putative metal binding site [ion binding]; other site
1117647001604	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1117647001605	lipoyl-biotinyl attachment site [posttranslational modification]; other site
1117647001606	HlyD family secretion protein; Region: HlyD_3; pfam13437
1117647001607	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
1117647001608	Nitrogen regulatory protein P-II; Region: P-II; cl00412
1117647001609	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1117647001610	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1117647001611	SprT-like family; Region: SprT-like; pfam10263
1117647001612	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
1117647001613	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
1117647001614	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1117647001615	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1117647001616	non-specific DNA binding site [nucleotide binding]; other site
1117647001617	salt bridge; other site
1117647001618	sequence-specific DNA binding site [nucleotide binding]; other site
1117647001619	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1117647001620	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1117647001621	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
1117647001622	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1117647001623	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117647001624	motif II; other site
1117647001625	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1117647001626	active site
1117647001627	DNA binding site [nucleotide binding]
1117647001628	Int/Topo IB signature motif; other site
1117647001629	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1117647001630	putative catalytic site [active]
1117647001631	putative metal binding site [ion binding]; other site
1117647001632	putative phosphate binding site [ion binding]; other site
1117647001633	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
1117647001634	AAA ATPase domain; Region: AAA_15; pfam13175
1117647001635	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
1117647001636	putative active site [active]
1117647001637	putative metal-binding site [ion binding]; other site
1117647001638	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
1117647001639	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1117647001640	DNA binding site [nucleotide binding]
1117647001641	Int/Topo IB signature motif; other site
1117647001642	active site
1117647001643	catalytic residues [active]
1117647001644	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
1117647001645	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
1117647001646	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1117647001647	active site
1117647001648	putative catalytic site [active]
1117647001649	metal binding site A [ion binding]; metal-binding site
1117647001650	putative phosphate binding site [ion binding]; other site
1117647001651	DNA binding site [nucleotide binding]
1117647001652	putative AP binding site [nucleotide binding]; other site
1117647001653	putative metal binding site B [ion binding]; other site
1117647001654	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117647001655	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647001656	ATP binding site [chemical binding]; other site
1117647001657	Mg2+ binding site [ion binding]; other site
1117647001658	G-X-G motif; other site
1117647001659	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1117647001660	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647001661	active site
1117647001662	phosphorylation site [posttranslational modification]
1117647001663	intermolecular recognition site; other site
1117647001664	dimerization interface [polypeptide binding]; other site
1117647001665	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117647001666	RNA polymerase factor sigma-70; Validated; Region: PRK09047
1117647001667	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1117647001668	DNA binding residues [nucleotide binding]
1117647001669	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
1117647001670	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1117647001671	dimerization interface [polypeptide binding]; other site
1117647001672	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1117647001673	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1117647001674	dimer interface [polypeptide binding]; other site
1117647001675	putative CheW interface [polypeptide binding]; other site
1117647001676	siroheme synthase; Provisional; Region: cysG; PRK10637
1117647001677	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1117647001678	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
1117647001679	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1117647001680	active site
1117647001681	SAM binding site [chemical binding]; other site
1117647001682	homodimer interface [polypeptide binding]; other site
1117647001683	seryl-tRNA synthetase; Provisional; Region: PRK05431
1117647001684	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1117647001685	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1117647001686	dimer interface [polypeptide binding]; other site
1117647001687	active site
1117647001688	motif 1; other site
1117647001689	motif 2; other site
1117647001690	motif 3; other site
1117647001691	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
1117647001692	recombination factor protein RarA; Reviewed; Region: PRK13342
1117647001693	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647001694	Walker A motif; other site
1117647001695	ATP binding site [chemical binding]; other site
1117647001696	Walker B motif; other site
1117647001697	arginine finger; other site
1117647001698	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1117647001699	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
1117647001700	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
1117647001701	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1117647001702	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1117647001703	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1117647001704	thioredoxin reductase; Provisional; Region: PRK10262
1117647001705	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1117647001706	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1117647001707	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
1117647001708	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
1117647001709	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
1117647001710	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
1117647001711	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1117647001712	rRNA binding site [nucleotide binding]; other site
1117647001713	predicted 30S ribosome binding site; other site
1117647001714	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
1117647001715	Clp amino terminal domain; Region: Clp_N; pfam02861
1117647001716	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647001717	Walker A motif; other site
1117647001718	ATP binding site [chemical binding]; other site
1117647001719	Walker B motif; other site
1117647001720	arginine finger; other site
1117647001721	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647001722	Walker A motif; other site
1117647001723	ATP binding site [chemical binding]; other site
1117647001724	Walker B motif; other site
1117647001725	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1117647001726	Uncharacterized conserved protein [Function unknown]; Region: COG2127
1117647001727	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1117647001728	DNA-binding site [nucleotide binding]; DNA binding site
1117647001729	RNA-binding motif; other site
1117647001730	isocitrate dehydrogenase; Validated; Region: PRK07362
1117647001731	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1117647001732	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1117647001733	pseudouridine synthase; Region: TIGR00093
1117647001734	active site
1117647001735	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
1117647001736	nudix motif; other site
1117647001737	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1117647001738	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1117647001739	putative lysogenization regulator; Reviewed; Region: PRK00218
1117647001740	adenylosuccinate lyase; Provisional; Region: PRK09285
1117647001741	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
1117647001742	tetramer interface [polypeptide binding]; other site
1117647001743	active site
1117647001744	Uncharacterized conserved protein [Function unknown]; Region: COG2850
1117647001745	Cupin-like domain; Region: Cupin_8; pfam13621
1117647001746	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1117647001747	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117647001748	Coenzyme A binding pocket [chemical binding]; other site
1117647001749	putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568
1117647001750	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1117647001751	malate synthase G; Provisional; Region: PRK02999
1117647001752	active site
1117647001753	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1117647001754	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117647001755	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1117647001756	substrate binding pocket [chemical binding]; other site
1117647001757	dimerization interface [polypeptide binding]; other site
1117647001758	isocitrate lyase; Provisional; Region: PRK15063
1117647001759	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1117647001760	tetramer interface [polypeptide binding]; other site
1117647001761	active site
1117647001762	Mg2+/Mn2+ binding site [ion binding]; other site
1117647001763	isocitrate lyase; Region: PLN02892
1117647001764	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
1117647001765	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1117647001766	iron-sulfur cluster [ion binding]; other site
1117647001767	[2Fe-2S] cluster binding site [ion binding]; other site
1117647001768	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1117647001769	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1117647001770	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1117647001771	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1117647001772	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1117647001773	Active Sites [active]
1117647001774	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
1117647001775	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117647001776	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
1117647001777	substrate binding site [chemical binding]; other site
1117647001778	dimerization interface [polypeptide binding]; other site
1117647001779	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1117647001780	Ligand Binding Site [chemical binding]; other site
1117647001781	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
1117647001782	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1117647001783	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
1117647001784	NADP binding site [chemical binding]; other site
1117647001785	dimer interface [polypeptide binding]; other site
1117647001786	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1117647001787	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117647001788	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1117647001789	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1117647001790	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1117647001791	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1117647001792	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1117647001793	active site
1117647001794	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1117647001795	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
1117647001796	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1117647001797	homodimer interface [polypeptide binding]; other site
1117647001798	metal binding site [ion binding]; metal-binding site
1117647001799	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1117647001800	homodimer interface [polypeptide binding]; other site
1117647001801	active site
1117647001802	putative chemical substrate binding site [chemical binding]; other site
1117647001803	metal binding site [ion binding]; metal-binding site
1117647001804	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1117647001805	HD domain; Region: HD_4; pfam13328
1117647001806	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1117647001807	synthetase active site [active]
1117647001808	NTP binding site [chemical binding]; other site
1117647001809	metal binding site [ion binding]; metal-binding site
1117647001810	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1117647001811	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1117647001812	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
1117647001813	TRAM domain; Region: TRAM; pfam01938
1117647001814	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647001815	S-adenosylmethionine binding site [chemical binding]; other site
1117647001816	cysteine synthase B; Region: cysM; TIGR01138
1117647001817	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1117647001818	dimer interface [polypeptide binding]; other site
1117647001819	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647001820	catalytic residue [active]
1117647001821	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1117647001822	Recombination protein O N terminal; Region: RecO_N; pfam11967
1117647001823	Recombination protein O C terminal; Region: RecO_C; pfam02565
1117647001824	ribonuclease III; Reviewed; Region: rnc; PRK00102
1117647001825	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1117647001826	dimerization interface [polypeptide binding]; other site
1117647001827	active site
1117647001828	metal binding site [ion binding]; metal-binding site
1117647001829	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1117647001830	signal peptidase I; Provisional; Region: PRK10861
1117647001831	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1117647001832	Catalytic site [active]
1117647001833	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1117647001834	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1117647001835	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1117647001836	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1117647001837	protein binding site [polypeptide binding]; other site
1117647001838	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1117647001839	protein binding site [polypeptide binding]; other site
1117647001840	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
1117647001841	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
1117647001842	anti-sigma E factor; Provisional; Region: rseB; PRK09455
1117647001843	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
1117647001844	RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923
1117647001845	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117647001846	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1117647001847	DNA binding residues [nucleotide binding]
1117647001848	L-aspartate oxidase; Provisional; Region: PRK09077
1117647001849	L-aspartate oxidase; Provisional; Region: PRK06175
1117647001850	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1117647001851	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
1117647001852	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
1117647001853	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1117647001854	HDOD domain; Region: HDOD; pfam08668
1117647001855	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1117647001856	ligand binding site [chemical binding]; other site
1117647001857	active site
1117647001858	UGI interface [polypeptide binding]; other site
1117647001859	catalytic site [active]
1117647001860	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1117647001861	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1117647001862	dimer interface [polypeptide binding]; other site
1117647001863	putative anticodon binding site; other site
1117647001864	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1117647001865	motif 1; other site
1117647001866	active site
1117647001867	motif 2; other site
1117647001868	motif 3; other site
1117647001869	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1117647001870	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1117647001871	RF-1 domain; Region: RF-1; pfam00472
1117647001872	Predicted permease; Region: DUF318; cl17795
1117647001873	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
1117647001874	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1117647001875	DNA binding residues [nucleotide binding]
1117647001876	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
1117647001877	FtsX-like permease family; Region: FtsX; pfam02687
1117647001878	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1117647001879	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
1117647001880	Walker A/P-loop; other site
1117647001881	ATP binding site [chemical binding]; other site
1117647001882	Q-loop/lid; other site
1117647001883	ABC transporter signature motif; other site
1117647001884	Walker B; other site
1117647001885	D-loop; other site
1117647001886	H-loop/switch region; other site
1117647001887	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
1117647001888	active site
1117647001889	catalytic triad [active]
1117647001890	oxyanion hole [active]
1117647001891	switch loop; other site
1117647001892	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
1117647001893	DHH family; Region: DHH; pfam01368
1117647001894	DHHA1 domain; Region: DHHA1; pfam02272
1117647001895	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
1117647001896	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1117647001897	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1117647001898	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1117647001899	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647001900	catalytic residue [active]
1117647001901	homoserine dehydrogenase; Provisional; Region: PRK06349
1117647001902	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1117647001903	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1117647001904	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1117647001905	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
1117647001906	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1117647001907	dimerization domain [polypeptide binding]; other site
1117647001908	dimer interface [polypeptide binding]; other site
1117647001909	catalytic residues [active]
1117647001910	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1117647001911	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1117647001912	active site
1117647001913	Int/Topo IB signature motif; other site
1117647001914	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1117647001915	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1117647001916	RimM N-terminal domain; Region: RimM; pfam01782
1117647001917	PRC-barrel domain; Region: PRC; pfam05239
1117647001918	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1117647001919	signal recognition particle protein; Provisional; Region: PRK10867
1117647001920	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1117647001921	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1117647001922	P loop; other site
1117647001923	GTP binding site [chemical binding]; other site
1117647001924	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1117647001925	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1117647001926	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
1117647001927	Domain of unknown function DUF21; Region: DUF21; pfam01595
1117647001928	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1117647001929	Transporter associated domain; Region: CorC_HlyC; smart01091
1117647001930	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1117647001931	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1117647001932	trimer interface [polypeptide binding]; other site
1117647001933	putative metal binding site [ion binding]; other site
1117647001934	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1117647001935	putative active site [active]
1117647001936	putative CoA binding site [chemical binding]; other site
1117647001937	nudix motif; other site
1117647001938	metal binding site [ion binding]; metal-binding site
1117647001939	Protein of unknown function (DUF3135); Region: DUF3135; pfam11333
1117647001940	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
1117647001941	nudix motif; other site
1117647001942	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1117647001943	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
1117647001944	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
1117647001945	putative ligand binding site [chemical binding]; other site
1117647001946	putative NAD binding site [chemical binding]; other site
1117647001947	putative catalytic site [active]
1117647001948	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
1117647001949	L-serine binding site [chemical binding]; other site
1117647001950	ACT domain interface; other site
1117647001951	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
1117647001952	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1117647001953	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1117647001954	catalytic residue [active]
1117647001955	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
1117647001956	active site
1117647001957	phosphate binding residues; other site
1117647001958	catalytic residues [active]
1117647001959	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1117647001960	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
1117647001961	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
1117647001962	Protein of unknown function (DUF3014); Region: DUF3014; pfam11219
1117647001963	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
1117647001964	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1117647001965	dimerization interface [polypeptide binding]; other site
1117647001966	ATP binding site [chemical binding]; other site
1117647001967	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1117647001968	dimerization interface [polypeptide binding]; other site
1117647001969	ATP binding site [chemical binding]; other site
1117647001970	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1117647001971	putative active site [active]
1117647001972	catalytic triad [active]
1117647001973	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
1117647001974	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1117647001975	membrane-bound complex binding site; other site
1117647001976	hinge residues; other site
1117647001977	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1117647001978	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1117647001979	catalytic residue [active]
1117647001980	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
1117647001981	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1117647001982	inhibitor-cofactor binding pocket; inhibition site
1117647001983	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647001984	catalytic residue [active]
1117647001985	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1117647001986	amino acid carrier protein; Region: agcS; TIGR00835
1117647001987	D-cysteine desulfhydrase; Validated; Region: PRK03910
1117647001988	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1117647001989	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1117647001990	catalytic residue [active]
1117647001991	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
1117647001992	Helix-turn-helix domain; Region: HTH_18; pfam12833
1117647001993	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1117647001994	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1117647001995	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1117647001996	catalytic triad [active]
1117647001997	malate dehydrogenase; Provisional; Region: PRK05442
1117647001998	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
1117647001999	NAD(P) binding site [chemical binding]; other site
1117647002000	dimer interface [polypeptide binding]; other site
1117647002001	malate binding site [chemical binding]; other site
1117647002002	dUTPase; Region: dUTPase_2; pfam08761
1117647002003	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
1117647002004	active site
1117647002005	homodimer interface [polypeptide binding]; other site
1117647002006	metal binding site [ion binding]; metal-binding site
1117647002007	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1117647002008	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1117647002009	active site
1117647002010	PilZ domain; Region: PilZ; cl01260
1117647002011	DNA polymerase III subunit delta'; Validated; Region: PRK05707
1117647002012	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1117647002013	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1117647002014	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1117647002015	active site
1117647002016	thymidylate kinase; Validated; Region: tmk; PRK00698
1117647002017	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1117647002018	TMP-binding site; other site
1117647002019	ATP-binding site [chemical binding]; other site
1117647002020	YceG-like family; Region: YceG; pfam02618
1117647002021	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1117647002022	dimerization interface [polypeptide binding]; other site
1117647002023	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1117647002024	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
1117647002025	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647002026	catalytic residue [active]
1117647002027	acyl carrier protein; Provisional; Region: acpP; PRK00982
1117647002028	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1117647002029	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1117647002030	NAD(P) binding site [chemical binding]; other site
1117647002031	homotetramer interface [polypeptide binding]; other site
1117647002032	homodimer interface [polypeptide binding]; other site
1117647002033	active site
1117647002034	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1117647002035	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1117647002036	putative phosphate acyltransferase; Provisional; Region: PRK05331
1117647002037	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
1117647002038	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
1117647002039	Maf-like protein; Region: Maf; pfam02545
1117647002040	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1117647002041	active site
1117647002042	dimer interface [polypeptide binding]; other site
1117647002043	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1117647002044	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117647002045	motif II; other site
1117647002046	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1117647002047	YccA-like proteins; Region: YccA_like; cd10433
1117647002048	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
1117647002049	DsrH like protein; Region: DsrH; cl17347
1117647002050	DsrC like protein; Region: DsrC; pfam04358
1117647002051	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
1117647002052	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
1117647002053	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
1117647002054	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647002055	S-adenosylmethionine binding site [chemical binding]; other site
1117647002056	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
1117647002057	RmuC family; Region: RmuC; pfam02646
1117647002058	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647002059	binding surface
1117647002060	TPR motif; other site
1117647002061	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1117647002062	nudix motif; other site
1117647002063	probable DNA repair protein; Region: TIGR03623
1117647002064	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1117647002065	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
1117647002066	Family description; Region: UvrD_C_2; pfam13538
1117647002067	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
1117647002068	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1117647002069	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
1117647002070	active site
1117647002071	catalytic residues [active]
1117647002072	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
1117647002073	PA/protease or protease-like domain interface [polypeptide binding]; other site
1117647002074	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1117647002075	catalytic residues [active]
1117647002076	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1117647002077	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1117647002078	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1117647002079	Proline racemase; Region: Pro_racemase; pfam05544
1117647002080	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1117647002081	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1117647002082	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
1117647002083	active site
1117647002084	ornithine cyclodeaminase; Validated; Region: PRK06141
1117647002085	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1117647002086	NAD(P) binding site [chemical binding]; other site
1117647002087	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647002088	putative substrate translocation pore; other site
1117647002089	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1117647002090	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1117647002091	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1117647002092	DNA-binding site [nucleotide binding]; DNA binding site
1117647002093	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1117647002094	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1117647002095	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
1117647002096	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1117647002097	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1117647002098	inhibitor site; inhibition site
1117647002099	active site
1117647002100	dimer interface [polypeptide binding]; other site
1117647002101	catalytic residue [active]
1117647002102	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1117647002103	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1117647002104	imidazolonepropionase; Validated; Region: PRK09356
1117647002105	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1117647002106	active site
1117647002107	formimidoylglutamase; Provisional; Region: PRK13775
1117647002108	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
1117647002109	putative active site [active]
1117647002110	putative metal binding site [ion binding]; other site
1117647002111	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1117647002112	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1117647002113	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
1117647002114	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1117647002115	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1117647002116	salt bridge; other site
1117647002117	non-specific DNA binding site [nucleotide binding]; other site
1117647002118	sequence-specific DNA binding site [nucleotide binding]; other site
1117647002119	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1117647002120	HSP70 interaction site [polypeptide binding]; other site
1117647002121	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1117647002122	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117647002123	motif II; other site
1117647002124	sensor protein PhoQ; Provisional; Region: PRK10815
1117647002125	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647002126	ATP binding site [chemical binding]; other site
1117647002127	Mg2+ binding site [ion binding]; other site
1117647002128	G-X-G motif; other site
1117647002129	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1117647002130	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647002131	active site
1117647002132	phosphorylation site [posttranslational modification]
1117647002133	intermolecular recognition site; other site
1117647002134	dimerization interface [polypeptide binding]; other site
1117647002135	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1117647002136	DNA binding site [nucleotide binding]
1117647002137	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
1117647002138	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647002139	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1117647002140	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
1117647002141	homodimer interface [polypeptide binding]; other site
1117647002142	oligomer interface [polypeptide binding]; other site
1117647002143	chemical substrate binding site [chemical binding]; other site
1117647002144	metal binding site [ion binding]; metal-binding site
1117647002145	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1117647002146	GIY-YIG motif/motif A; other site
1117647002147	putative active site [active]
1117647002148	putative metal binding site [ion binding]; other site
1117647002149	Protein of unknown function, DUF599; Region: DUF599; pfam04654
1117647002150	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
1117647002151	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1117647002152	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1117647002153	Peptidase M16C associated; Region: M16C_assoc; pfam08367
1117647002154	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1117647002155	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1117647002156	active site
1117647002157	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
1117647002158	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1117647002159	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1117647002160	active site
1117647002161	YebG protein; Region: YebG; cl01217
1117647002162	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1117647002163	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647002164	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1117647002165	N-terminal plug; other site
1117647002166	ligand-binding site [chemical binding]; other site
1117647002167	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1117647002168	3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605
1117647002169	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1117647002170	PAS fold; Region: PAS_7; pfam12860
1117647002171	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117647002172	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647002173	ATP binding site [chemical binding]; other site
1117647002174	Mg2+ binding site [ion binding]; other site
1117647002175	G-X-G motif; other site
1117647002176	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1117647002177	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647002178	active site
1117647002179	phosphorylation site [posttranslational modification]
1117647002180	intermolecular recognition site; other site
1117647002181	dimerization interface [polypeptide binding]; other site
1117647002182	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1117647002183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647002184	active site
1117647002185	phosphorylation site [posttranslational modification]
1117647002186	intermolecular recognition site; other site
1117647002187	dimerization interface [polypeptide binding]; other site
1117647002188	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1117647002189	DNA binding residues [nucleotide binding]
1117647002190	dimerization interface [polypeptide binding]; other site
1117647002191	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117647002192	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
1117647002193	NAD(P) binding site [chemical binding]; other site
1117647002194	active site
1117647002195	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117647002196	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647002197	ATP binding site [chemical binding]; other site
1117647002198	Mg2+ binding site [ion binding]; other site
1117647002199	G-X-G motif; other site
1117647002200	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
1117647002201	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647002202	active site
1117647002203	phosphorylation site [posttranslational modification]
1117647002204	intermolecular recognition site; other site
1117647002205	dimerization interface [polypeptide binding]; other site
1117647002206	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647002207	binding surface
1117647002208	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1117647002209	TPR motif; other site
1117647002210	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647002211	S-adenosylmethionine binding site [chemical binding]; other site
1117647002212	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1117647002213	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647002214	S-adenosylmethionine binding site [chemical binding]; other site
1117647002215	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
1117647002216	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1117647002217	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1117647002218	DNA binding site [nucleotide binding]
1117647002219	active site
1117647002220	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
1117647002221	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1117647002222	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1117647002223	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1117647002224	AlkA N-terminal domain; Region: AlkA_N; pfam06029
1117647002225	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
1117647002226	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1117647002227	minor groove reading motif; other site
1117647002228	helix-hairpin-helix signature motif; other site
1117647002229	substrate binding pocket [chemical binding]; other site
1117647002230	active site
1117647002231	flavodoxin FldA; Validated; Region: PRK09267
1117647002232	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1117647002233	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117647002234	ATP binding site [chemical binding]; other site
1117647002235	putative Mg++ binding site [ion binding]; other site
1117647002236	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117647002237	nucleotide binding region [chemical binding]; other site
1117647002238	ATP-binding site [chemical binding]; other site
1117647002239	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1117647002240	HRDC domain; Region: HRDC; pfam00570
1117647002241	S-formylglutathione hydrolase; Region: PLN02442
1117647002242	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
1117647002243	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1117647002244	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1117647002245	substrate binding site [chemical binding]; other site
1117647002246	catalytic Zn binding site [ion binding]; other site
1117647002247	NAD binding site [chemical binding]; other site
1117647002248	structural Zn binding site [ion binding]; other site
1117647002249	dimer interface [polypeptide binding]; other site
1117647002250	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1117647002251	AAA domain; Region: AAA_33; pfam13671
1117647002252	ATP-binding site [chemical binding]; other site
1117647002253	Gluconate-6-phosphate binding site [chemical binding]; other site
1117647002254	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1117647002255	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1117647002256	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1117647002257	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117647002258	dimer interface [polypeptide binding]; other site
1117647002259	conserved gate region; other site
1117647002260	putative PBP binding loops; other site
1117647002261	ABC-ATPase subunit interface; other site
1117647002262	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1117647002263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117647002264	dimer interface [polypeptide binding]; other site
1117647002265	conserved gate region; other site
1117647002266	putative PBP binding loops; other site
1117647002267	ABC-ATPase subunit interface; other site
1117647002268	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1117647002269	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1117647002270	Walker A/P-loop; other site
1117647002271	ATP binding site [chemical binding]; other site
1117647002272	Q-loop/lid; other site
1117647002273	ABC transporter signature motif; other site
1117647002274	Walker B; other site
1117647002275	D-loop; other site
1117647002276	H-loop/switch region; other site
1117647002277	TOBE domain; Region: TOBE_2; pfam08402
1117647002278	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1117647002279	beta-galactosidase; Region: BGL; TIGR03356
1117647002280	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1117647002281	putative FMN binding site [chemical binding]; other site
1117647002282	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
1117647002283	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1117647002284	cyclase homology domain; Region: CHD; cd07302
1117647002285	nucleotidyl binding site; other site
1117647002286	metal binding site [ion binding]; metal-binding site
1117647002287	dimer interface [polypeptide binding]; other site
1117647002288	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
1117647002289	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
1117647002290	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1117647002291	inner membrane transport permease; Provisional; Region: PRK15066
1117647002292	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1117647002293	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1117647002294	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1117647002295	Walker A/P-loop; other site
1117647002296	ATP binding site [chemical binding]; other site
1117647002297	Q-loop/lid; other site
1117647002298	ABC transporter signature motif; other site
1117647002299	Walker B; other site
1117647002300	D-loop; other site
1117647002301	H-loop/switch region; other site
1117647002302	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
1117647002303	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
1117647002304	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1117647002305	SelR domain; Region: SelR; pfam01641
1117647002306	aminotransferase AlaT; Validated; Region: PRK09265
1117647002307	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1117647002308	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647002309	homodimer interface [polypeptide binding]; other site
1117647002310	catalytic residue [active]
1117647002311	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
1117647002312	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647002313	S-adenosylmethionine binding site [chemical binding]; other site
1117647002314	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
1117647002315	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1117647002316	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
1117647002317	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
1117647002318	ligand binding site [chemical binding]; other site
1117647002319	NAD binding site [chemical binding]; other site
1117647002320	catalytic site [active]
1117647002321	homodimer interface [polypeptide binding]; other site
1117647002322	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1117647002323	5'-3' exonuclease; Region: 53EXOc; smart00475
1117647002324	active site
1117647002325	metal binding site 1 [ion binding]; metal-binding site
1117647002326	putative 5' ssDNA interaction site; other site
1117647002327	metal binding site 3; metal-binding site
1117647002328	metal binding site 2 [ion binding]; metal-binding site
1117647002329	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1117647002330	putative DNA binding site [nucleotide binding]; other site
1117647002331	putative metal binding site [ion binding]; other site
1117647002332	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
1117647002333	CPxP  motif; other site
1117647002334	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1117647002335	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
1117647002336	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1117647002337	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1117647002338	Uncharacterized protein family (UPF0270); Region: UPF0270; pfam06794
1117647002339	Predicted methyltransferase [General function prediction only]; Region: COG4798
1117647002340	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1117647002341	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
1117647002342	ACT domain; Region: ACT_6; pfam13740
1117647002343	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
1117647002344	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1117647002345	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
1117647002346	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1117647002347	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1117647002348	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1117647002349	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647002350	TPR motif; other site
1117647002351	binding surface
1117647002352	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
1117647002353	Secretin N-terminal domain; Region: Secretin_N_2; pfam07655
1117647002354	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
1117647002355	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1117647002356	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
1117647002357	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1117647002358	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1117647002359	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1117647002360	MAPEG family; Region: MAPEG; cl09190
1117647002361	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
1117647002362	Uncharacterized conserved protein [Function unknown]; Region: COG4121
1117647002363	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1117647002364	Late competence development protein ComFB; Region: ComFB; pfam10719
1117647002365	Protein of unknown function (DUF502); Region: DUF502; cl01107
1117647002366	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
1117647002367	Protein of unknown function, DUF484; Region: DUF484; cl17449
1117647002368	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647002369	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647002370	metal binding site [ion binding]; metal-binding site
1117647002371	active site
1117647002372	I-site; other site
1117647002373	putative protease; Provisional; Region: PRK15452
1117647002374	Peptidase family U32; Region: Peptidase_U32; pfam01136
1117647002375	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1117647002376	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1117647002377	Predicted transcriptional regulators [Transcription]; Region: COG1695
1117647002378	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1117647002379	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
1117647002380	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1117647002381	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
1117647002382	putative active site [active]
1117647002383	catalytic site [active]
1117647002384	putative metal binding site [ion binding]; other site
1117647002385	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
1117647002386	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1117647002387	L-fucose transporter; Provisional; Region: PRK10133; cl17665
1117647002388	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
1117647002389	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
1117647002390	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
1117647002391	active site
1117647002392	Fn3 associated; Region: Fn3_assoc; pfam13287
1117647002393	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
1117647002394	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
1117647002395	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
1117647002396	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647002397	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647002398	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1117647002399	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
1117647002400	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1117647002401	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1117647002402	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1117647002403	Surface antigen; Region: Bac_surface_Ag; pfam01103
1117647002404	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1117647002405	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1117647002406	active site
1117647002407	ATP binding site [chemical binding]; other site
1117647002408	substrate binding site [chemical binding]; other site
1117647002409	activation loop (A-loop); other site
1117647002410	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1117647002411	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1117647002412	phosphopeptide binding site; other site
1117647002413	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
1117647002414	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
1117647002415	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
1117647002416	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
1117647002417	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1117647002418	G1 box; other site
1117647002419	GTP/Mg2+ binding site [chemical binding]; other site
1117647002420	G2 box; other site
1117647002421	G3 box; other site
1117647002422	Switch II region; other site
1117647002423	G4 box; other site
1117647002424	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1117647002425	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1117647002426	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867
1117647002427	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
1117647002428	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
1117647002429	Protein of unknown function (DUF770); Region: DUF770; pfam05591
1117647002430	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
1117647002431	Protein of unknown function (DUF877); Region: DUF877; pfam05943
1117647002432	Protein of unknown function (DUF877); Region: DUF877; pfam05943
1117647002433	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
1117647002434	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
1117647002435	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
1117647002436	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
1117647002437	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
1117647002438	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
1117647002439	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647002440	Walker A motif; other site
1117647002441	ATP binding site [chemical binding]; other site
1117647002442	Walker B motif; other site
1117647002443	arginine finger; other site
1117647002444	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647002445	Walker A motif; other site
1117647002446	ATP binding site [chemical binding]; other site
1117647002447	Walker B motif; other site
1117647002448	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1117647002449	PAAR motif; Region: PAAR_motif; pfam05488
1117647002450	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
1117647002451	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1117647002452	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1117647002453	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
1117647002454	Protein of unknown function (DUF796); Region: DUF796; pfam05638
1117647002455	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
1117647002456	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1117647002457	nucleoside/Zn binding site; other site
1117647002458	dimer interface [polypeptide binding]; other site
1117647002459	catalytic motif [active]
1117647002460	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
1117647002461	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1117647002462	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
1117647002463	FAD binding pocket [chemical binding]; other site
1117647002464	FAD binding motif [chemical binding]; other site
1117647002465	phosphate binding motif [ion binding]; other site
1117647002466	beta-alpha-beta structure motif; other site
1117647002467	NAD binding pocket [chemical binding]; other site
1117647002468	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
1117647002469	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117647002470	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1117647002471	putative dimerization interface [polypeptide binding]; other site
1117647002472	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1117647002473	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1117647002474	ring oligomerisation interface [polypeptide binding]; other site
1117647002475	ATP/Mg binding site [chemical binding]; other site
1117647002476	stacking interactions; other site
1117647002477	hinge regions; other site
1117647002478	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1117647002479	oligomerisation interface [polypeptide binding]; other site
1117647002480	mobile loop; other site
1117647002481	roof hairpin; other site
1117647002482	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1117647002483	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1117647002484	putative DNA binding site [nucleotide binding]; other site
1117647002485	putative Zn2+ binding site [ion binding]; other site
1117647002486	AsnC family; Region: AsnC_trans_reg; pfam01037
1117647002487	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
1117647002488	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1117647002489	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1117647002490	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647002491	homodimer interface [polypeptide binding]; other site
1117647002492	catalytic residue [active]
1117647002493	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1117647002494	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1117647002495	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1117647002496	putative active site [active]
1117647002497	putative substrate binding site [chemical binding]; other site
1117647002498	putative cosubstrate binding site; other site
1117647002499	catalytic site [active]
1117647002500	Peptidase C26; Region: Peptidase_C26; pfam07722
1117647002501	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1117647002502	catalytic triad [active]
1117647002503	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
1117647002504	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647002505	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1117647002506	putative substrate translocation pore; other site
1117647002507	Gram-negative bacterial tonB protein; Region: TonB; cl10048
1117647002508	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1117647002509	TPR repeat; Region: TPR_11; pfam13414
1117647002510	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647002511	binding surface
1117647002512	TPR motif; other site
1117647002513	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
1117647002514	PEGA domain; Region: PEGA; pfam08308
1117647002515	PEGA domain; Region: PEGA; pfam08308
1117647002516	PEGA domain; Region: PEGA; pfam08308
1117647002517	PEGA domain; Region: PEGA; pfam08308
1117647002518	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1117647002519	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1117647002520	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1117647002521	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1117647002522	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1117647002523	metal ion-dependent adhesion site (MIDAS); other site
1117647002524	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1117647002525	metal ion-dependent adhesion site (MIDAS); other site
1117647002526	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
1117647002527	Peptidase family M48; Region: Peptidase_M48; pfam01435
1117647002528	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1117647002529	putative acyl-acceptor binding pocket; other site
1117647002530	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
1117647002531	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
1117647002532	active site
1117647002533	catalytic residues [active]
1117647002534	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
1117647002535	PA/protease or protease-like domain interface [polypeptide binding]; other site
1117647002536	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1117647002537	catalytic residues [active]
1117647002538	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1117647002539	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647002540	S-adenosylmethionine binding site [chemical binding]; other site
1117647002541	GTP-binding protein Der; Reviewed; Region: PRK00093
1117647002542	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1117647002543	G1 box; other site
1117647002544	GTP/Mg2+ binding site [chemical binding]; other site
1117647002545	Switch I region; other site
1117647002546	G2 box; other site
1117647002547	Switch II region; other site
1117647002548	G3 box; other site
1117647002549	G4 box; other site
1117647002550	G5 box; other site
1117647002551	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1117647002552	G1 box; other site
1117647002553	GTP/Mg2+ binding site [chemical binding]; other site
1117647002554	Switch I region; other site
1117647002555	G2 box; other site
1117647002556	G3 box; other site
1117647002557	Switch II region; other site
1117647002558	G4 box; other site
1117647002559	G5 box; other site
1117647002560	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1117647002561	Trp docking motif [polypeptide binding]; other site
1117647002562	active site
1117647002563	PQQ-like domain; Region: PQQ_2; pfam13360
1117647002564	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
1117647002565	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1117647002566	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1117647002567	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1117647002568	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1117647002569	Helix-turn-helix domain; Region: HTH_25; pfam13413
1117647002570	non-specific DNA binding site [nucleotide binding]; other site
1117647002571	salt bridge; other site
1117647002572	sequence-specific DNA binding site [nucleotide binding]; other site
1117647002573	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1117647002574	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
1117647002575	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647002576	binding surface
1117647002577	TPR motif; other site
1117647002578	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1117647002579	binding surface
1117647002580	TPR motif; other site
1117647002581	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
1117647002582	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1117647002583	FeS/SAM binding site; other site
1117647002584	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1117647002585	active site
1117647002586	multimer interface [polypeptide binding]; other site
1117647002587	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
1117647002588	Domain of unknown function DUF59; Region: DUF59; cl00941
1117647002589	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
1117647002590	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1117647002591	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1117647002592	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1117647002593	catalytic residue [active]
1117647002594	FeS assembly protein SufD; Region: sufD; TIGR01981
1117647002595	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
1117647002596	FeS assembly ATPase SufC; Region: sufC; TIGR01978
1117647002597	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1117647002598	Walker A/P-loop; other site
1117647002599	ATP binding site [chemical binding]; other site
1117647002600	Q-loop/lid; other site
1117647002601	ABC transporter signature motif; other site
1117647002602	Walker B; other site
1117647002603	D-loop; other site
1117647002604	H-loop/switch region; other site
1117647002605	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
1117647002606	putative ABC transporter; Region: ycf24; CHL00085
1117647002607	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1117647002608	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1117647002609	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1117647002610	catalytic residue [active]
1117647002611	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
1117647002612	Rrf2 family protein; Region: rrf2_super; TIGR00738
1117647002613	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
1117647002614	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1117647002615	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1117647002616	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1117647002617	active site
1117647002618	dimerization interface [polypeptide binding]; other site
1117647002619	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647002620	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1117647002621	putative active site [active]
1117647002622	heme pocket [chemical binding]; other site
1117647002623	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647002624	putative active site [active]
1117647002625	heme pocket [chemical binding]; other site
1117647002626	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117647002627	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647002628	dimer interface [polypeptide binding]; other site
1117647002629	phosphorylation site [posttranslational modification]
1117647002630	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647002631	ATP binding site [chemical binding]; other site
1117647002632	Mg2+ binding site [ion binding]; other site
1117647002633	G-X-G motif; other site
1117647002634	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1117647002635	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647002636	active site
1117647002637	phosphorylation site [posttranslational modification]
1117647002638	intermolecular recognition site; other site
1117647002639	dimerization interface [polypeptide binding]; other site
1117647002640	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1117647002641	Protein export membrane protein; Region: SecD_SecF; pfam02355
1117647002642	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
1117647002643	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1117647002644	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1117647002645	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1117647002646	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1117647002647	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1117647002648	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1117647002649	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1117647002650	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
1117647002651	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1117647002652	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1117647002653	MarR family; Region: MarR_2; cl17246
1117647002654	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
1117647002655	fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266
1117647002656	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
1117647002657	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1117647002658	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
1117647002659	maleylacetoacetate isomerase; Region: maiA; TIGR01262
1117647002660	C-terminal domain interface [polypeptide binding]; other site
1117647002661	GSH binding site (G-site) [chemical binding]; other site
1117647002662	putative dimer interface [polypeptide binding]; other site
1117647002663	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
1117647002664	dimer interface [polypeptide binding]; other site
1117647002665	N-terminal domain interface [polypeptide binding]; other site
1117647002666	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
1117647002667	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1117647002668	dimer interface [polypeptide binding]; other site
1117647002669	catalytic triad [active]
1117647002670	peroxidatic and resolving cysteines [active]
1117647002671	cyclase homology domain; Region: CHD; cd07302
1117647002672	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1117647002673	nucleotidyl binding site; other site
1117647002674	metal binding site [ion binding]; metal-binding site
1117647002675	dimer interface [polypeptide binding]; other site
1117647002676	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1117647002677	phosphopeptide binding site; other site
1117647002678	RDD family; Region: RDD; pfam06271
1117647002679	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1117647002680	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1117647002681	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1117647002682	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1117647002683	FAD binding domain; Region: FAD_binding_4; pfam01565
1117647002684	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1117647002685	indolepyruvate/phenylpyruvate decarboxylase, Azospirillum family; Region: indol_phenyl_DC; TIGR03394
1117647002686	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1117647002687	PYR/PP interface [polypeptide binding]; other site
1117647002688	dimer interface [polypeptide binding]; other site
1117647002689	TPP binding site [chemical binding]; other site
1117647002690	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1117647002691	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1117647002692	TPP-binding site [chemical binding]; other site
1117647002693	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1117647002694	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
1117647002695	active site
1117647002696	FMN binding site [chemical binding]; other site
1117647002697	2,4-decadienoyl-CoA binding site; other site
1117647002698	catalytic residue [active]
1117647002699	4Fe-4S cluster binding site [ion binding]; other site
1117647002700	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1117647002701	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1117647002702	enoyl-CoA hydratase; Provisional; Region: PRK06142
1117647002703	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1117647002704	substrate binding site [chemical binding]; other site
1117647002705	oxyanion hole (OAH) forming residues; other site
1117647002706	trimer interface [polypeptide binding]; other site
1117647002707	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
1117647002708	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1117647002709	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117647002710	WHG domain; Region: WHG; pfam13305
1117647002711	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1117647002712	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1117647002713	Peptidase family M23; Region: Peptidase_M23; pfam01551
1117647002714	Domain of unknown function (DUF368); Region: DUF368; pfam04018
1117647002715	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
1117647002716	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647002717	S-adenosylmethionine binding site [chemical binding]; other site
1117647002718	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
1117647002719	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
1117647002720	Permutation of conserved domain; other site
1117647002721	active site
1117647002722	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1117647002723	homotrimer interaction site [polypeptide binding]; other site
1117647002724	zinc binding site [ion binding]; other site
1117647002725	CDP-binding sites; other site
1117647002726	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1117647002727	substrate binding site; other site
1117647002728	dimer interface; other site
1117647002729	enolase; Provisional; Region: eno; PRK00077
1117647002730	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1117647002731	dimer interface [polypeptide binding]; other site
1117647002732	metal binding site [ion binding]; metal-binding site
1117647002733	substrate binding pocket [chemical binding]; other site
1117647002734	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1117647002735	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
1117647002736	CTP synthetase; Validated; Region: pyrG; PRK05380
1117647002737	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1117647002738	Catalytic site [active]
1117647002739	active site
1117647002740	UTP binding site [chemical binding]; other site
1117647002741	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1117647002742	active site
1117647002743	putative oxyanion hole; other site
1117647002744	catalytic triad [active]
1117647002745	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
1117647002746	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1117647002747	Ligand Binding Site [chemical binding]; other site
1117647002748	TilS substrate binding domain; Region: TilS; pfam09179
1117647002749	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
1117647002750	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1117647002751	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1117647002752	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1117647002753	active site
1117647002754	ATP binding site [chemical binding]; other site
1117647002755	substrate binding site [chemical binding]; other site
1117647002756	activation loop (A-loop); other site
1117647002757	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
1117647002758	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
1117647002759	metal binding site [ion binding]; metal-binding site
1117647002760	dimer interface [polypeptide binding]; other site
1117647002761	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
1117647002762	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
1117647002763	Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234
1117647002764	putative active site [active]
1117647002765	Zn binding site [ion binding]; other site
1117647002766	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
1117647002767	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
1117647002768	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647002769	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1117647002770	TrkA-C domain; Region: TrkA_C; pfam02080
1117647002771	TrkA-C domain; Region: TrkA_C; pfam02080
1117647002772	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1117647002773	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1117647002774	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
1117647002775	putative GSH binding site [chemical binding]; other site
1117647002776	catalytic residues [active]
1117647002777	Domain of unknown function (DUF1704); Region: DUF1704; pfam08014
1117647002778	acetylornithine aminotransferase; Provisional; Region: PRK02627
1117647002779	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1117647002780	inhibitor-cofactor binding pocket; inhibition site
1117647002781	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647002782	catalytic residue [active]
1117647002783	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1117647002784	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1117647002785	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1117647002786	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
1117647002787	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
1117647002788	active site
1117647002789	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1117647002790	active site
1117647002791	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192
1117647002792	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117647002793	active site
1117647002794	motif I; other site
1117647002795	motif II; other site
1117647002796	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1117647002797	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
1117647002798	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
1117647002799	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1117647002800	active site
1117647002801	homodimer interface [polypeptide binding]; other site
1117647002802	catalytic site [active]
1117647002803	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1117647002804	Uncharacterized conserved protein [Function unknown]; Region: COG2968
1117647002805	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1117647002806	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1117647002807	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1117647002808	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647002809	putative substrate translocation pore; other site
1117647002810	mechanosensitive channel MscS; Provisional; Region: PRK10334
1117647002811	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1117647002812	Protein of unknown function (DUF770); Region: DUF770; cl01402
1117647002813	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
1117647002814	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1117647002815	OsmC-like protein; Region: OsmC; pfam02566
1117647002816	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
1117647002817	TM2 domain; Region: TM2; cl00984
1117647002818	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1117647002819	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1117647002820	EamA-like transporter family; Region: EamA; pfam00892
1117647002821	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642
1117647002822	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
1117647002823	putative metal binding site [ion binding]; other site
1117647002824	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1117647002825	Interdomain contacts; other site
1117647002826	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1117647002827	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1117647002828	active site
1117647002829	ATP binding site [chemical binding]; other site
1117647002830	substrate binding site [chemical binding]; other site
1117647002831	activation loop (A-loop); other site
1117647002832	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
1117647002833	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1117647002834	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1117647002835	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1117647002836	OmpW family; Region: OmpW; cl17427
1117647002837	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1117647002838	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
1117647002839	putative active site [active]
1117647002840	putative PHP Thumb interface [polypeptide binding]; other site
1117647002841	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1117647002842	generic binding surface II; other site
1117647002843	generic binding surface I; other site
1117647002844	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1117647002845	RNA/DNA hybrid binding site [nucleotide binding]; other site
1117647002846	active site
1117647002847	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1117647002848	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1117647002849	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1117647002850	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1117647002851	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1117647002852	inhibitor-cofactor binding pocket; inhibition site
1117647002853	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647002854	catalytic residue [active]
1117647002855	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
1117647002856	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1117647002857	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1117647002858	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117647002859	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1117647002860	putative effector binding pocket; other site
1117647002861	dimerization interface [polypeptide binding]; other site
1117647002862	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117647002863	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1117647002864	NAD(P) binding site [chemical binding]; other site
1117647002865	active site
1117647002866	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1117647002867	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
1117647002868	dimer interface [polypeptide binding]; other site
1117647002869	active site
1117647002870	heme binding site [chemical binding]; other site
1117647002871	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
1117647002872	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1117647002873	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1117647002874	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1117647002875	catalytic residue [active]
1117647002876	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1117647002877	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1117647002878	putative DNA binding site [nucleotide binding]; other site
1117647002879	putative Zn2+ binding site [ion binding]; other site
1117647002880	AsnC family; Region: AsnC_trans_reg; pfam01037
1117647002881	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1117647002882	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1117647002883	putative acyl-acceptor binding pocket; other site
1117647002884	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1117647002885	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1117647002886	active site
1117647002887	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1117647002888	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1117647002889	active site
1117647002890	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1117647002891	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1117647002892	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1117647002893	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1117647002894	trimer interface [polypeptide binding]; other site
1117647002895	active site
1117647002896	UDP-GlcNAc binding site [chemical binding]; other site
1117647002897	lipid binding site [chemical binding]; lipid-binding site
1117647002898	periplasmic chaperone; Provisional; Region: PRK10780
1117647002899	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
1117647002900	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
1117647002901	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1117647002902	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1117647002903	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1117647002904	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1117647002905	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1117647002906	Surface antigen; Region: Bac_surface_Ag; pfam01103
1117647002907	zinc metallopeptidase RseP; Provisional; Region: PRK10779
1117647002908	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1117647002909	active site
1117647002910	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1117647002911	protein binding site [polypeptide binding]; other site
1117647002912	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1117647002913	protein binding site [polypeptide binding]; other site
1117647002914	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1117647002915	putative substrate binding region [chemical binding]; other site
1117647002916	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1117647002917	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1117647002918	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1117647002919	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1117647002920	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
1117647002921	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1117647002922	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1117647002923	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
1117647002924	catalytic residue [active]
1117647002925	putative FPP diphosphate  binding site; other site
1117647002926	putative FPP binding hydrophobic cleft; other site
1117647002927	dimer interface [polypeptide binding]; other site
1117647002928	putative IPP diphosphate binding site; other site
1117647002929	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1117647002930	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1117647002931	hinge region; other site
1117647002932	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1117647002933	putative nucleotide binding site [chemical binding]; other site
1117647002934	uridine monophosphate binding site [chemical binding]; other site
1117647002935	homohexameric interface [polypeptide binding]; other site
1117647002936	elongation factor Ts; Provisional; Region: tsf; PRK09377
1117647002937	UBA/TS-N domain; Region: UBA; pfam00627
1117647002938	Elongation factor TS; Region: EF_TS; pfam00889
1117647002939	Elongation factor TS; Region: EF_TS; pfam00889
1117647002940	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1117647002941	rRNA interaction site [nucleotide binding]; other site
1117647002942	S8 interaction site; other site
1117647002943	putative laminin-1 binding site; other site
1117647002944	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1117647002945	active site
1117647002946	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
1117647002947	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1117647002948	metal binding triad; other site
1117647002949	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1117647002950	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1117647002951	Zn2+ binding site [ion binding]; other site
1117647002952	Mg2+ binding site [ion binding]; other site
1117647002953	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
1117647002954	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
1117647002955	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
1117647002956	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1117647002957	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647002958	homodimer interface [polypeptide binding]; other site
1117647002959	catalytic residue [active]
1117647002960	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1117647002961	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1117647002962	minor groove reading motif; other site
1117647002963	helix-hairpin-helix signature motif; other site
1117647002964	substrate binding pocket [chemical binding]; other site
1117647002965	active site
1117647002966	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
1117647002967	ArsC family; Region: ArsC; pfam03960
1117647002968	putative catalytic residues [active]
1117647002969	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536
1117647002970	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
1117647002971	putative trimer interface [polypeptide binding]; other site
1117647002972	putative CoA binding site [chemical binding]; other site
1117647002973	PAS fold; Region: PAS_3; pfam08447
1117647002974	PAS fold; Region: PAS_4; pfam08448
1117647002975	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647002976	putative active site [active]
1117647002977	heme pocket [chemical binding]; other site
1117647002978	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647002979	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1117647002980	putative active site [active]
1117647002981	heme pocket [chemical binding]; other site
1117647002982	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647002983	dimer interface [polypeptide binding]; other site
1117647002984	phosphorylation site [posttranslational modification]
1117647002985	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647002986	ATP binding site [chemical binding]; other site
1117647002987	Mg2+ binding site [ion binding]; other site
1117647002988	G-X-G motif; other site
1117647002989	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1117647002990	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647002991	active site
1117647002992	phosphorylation site [posttranslational modification]
1117647002993	intermolecular recognition site; other site
1117647002994	dimerization interface [polypeptide binding]; other site
1117647002995	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
1117647002996	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
1117647002997	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
1117647002998	metal binding site [ion binding]; metal-binding site
1117647002999	dimer interface [polypeptide binding]; other site
1117647003000	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
1117647003001	HemN C-terminal domain; Region: HemN_C; pfam06969
1117647003002	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1117647003003	trimer interface [polypeptide binding]; other site
1117647003004	dimer interface [polypeptide binding]; other site
1117647003005	putative active site [active]
1117647003006	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1117647003007	MoaE interaction surface [polypeptide binding]; other site
1117647003008	MoeB interaction surface [polypeptide binding]; other site
1117647003009	thiocarboxylated glycine; other site
1117647003010	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1117647003011	MoaE homodimer interface [polypeptide binding]; other site
1117647003012	MoaD interaction [polypeptide binding]; other site
1117647003013	active site residues [active]
1117647003014	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647003015	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647003016	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
1117647003017	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
1117647003018	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
1117647003019	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1117647003020	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
1117647003021	NADP+ binding site [chemical binding]; other site
1117647003022	folate binding site [chemical binding]; other site
1117647003023	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1117647003024	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1117647003025	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1117647003026	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1117647003027	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1117647003028	minor groove reading motif; other site
1117647003029	helix-hairpin-helix signature motif; other site
1117647003030	substrate binding pocket [chemical binding]; other site
1117647003031	active site
1117647003032	Hemerythrin family; Region: Hemerythrin-like; cl15774
1117647003033	Protein of unknown function (DUF523); Region: DUF523; pfam04463
1117647003034	Uncharacterized conserved protein [Function unknown]; Region: COG3272
1117647003035	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
1117647003036	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
1117647003037	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1117647003038	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1117647003039	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
1117647003040	active site
1117647003041	PBP superfamily domain; Region: PBP_like_2; cl17296
1117647003042	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1117647003043	ligand binding site [chemical binding]; other site
1117647003044	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1117647003045	ligand binding site [chemical binding]; other site
1117647003046	Leucine rich repeat; Region: LRR_8; pfam13855
1117647003047	PilZ domain; Region: PilZ; pfam07238
1117647003048	peroxidase; Provisional; Region: PRK15000
1117647003049	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1117647003050	dimer interface [polypeptide binding]; other site
1117647003051	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1117647003052	catalytic triad [active]
1117647003053	peroxidatic and resolving cysteines [active]
1117647003054	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
1117647003055	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
1117647003056	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1117647003057	heme binding site [chemical binding]; other site
1117647003058	ferroxidase pore; other site
1117647003059	ferroxidase diiron center [ion binding]; other site
1117647003060	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1117647003061	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1117647003062	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1117647003063	dimer interface [polypeptide binding]; other site
1117647003064	motif 1; other site
1117647003065	active site
1117647003066	motif 2; other site
1117647003067	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1117647003068	putative deacylase active site [active]
1117647003069	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1117647003070	active site
1117647003071	motif 3; other site
1117647003072	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1117647003073	anticodon binding site; other site
1117647003074	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1117647003075	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1117647003076	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1117647003077	catalytic residue [active]
1117647003078	Sensors of blue-light using FAD; Region: BLUF; pfam04940
1117647003079	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
1117647003080	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1117647003081	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647003082	homodimer interface [polypeptide binding]; other site
1117647003083	catalytic residue [active]
1117647003084	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1117647003085	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117647003086	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1117647003087	substrate binding pocket [chemical binding]; other site
1117647003088	dimerization interface [polypeptide binding]; other site
1117647003089	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1117647003090	phosphoglycerate mutase; Provisional; Region: PTZ00122
1117647003091	catalytic core [active]
1117647003092	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
1117647003093	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647003094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647003095	active site
1117647003096	phosphorylation site [posttranslational modification]
1117647003097	intermolecular recognition site; other site
1117647003098	dimerization interface [polypeptide binding]; other site
1117647003099	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1117647003100	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1117647003101	catalytic residues [active]
1117647003102	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
1117647003103	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1117647003104	ArsC family; Region: ArsC; pfam03960
1117647003105	catalytic residues [active]
1117647003106	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
1117647003107	protease 4; Provisional; Region: PRK10949
1117647003108	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
1117647003109	tandem repeat interface [polypeptide binding]; other site
1117647003110	oligomer interface [polypeptide binding]; other site
1117647003111	active site residues [active]
1117647003112	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1117647003113	tandem repeat interface [polypeptide binding]; other site
1117647003114	oligomer interface [polypeptide binding]; other site
1117647003115	active site residues [active]
1117647003116	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1117647003117	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
1117647003118	DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420
1117647003119	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1117647003120	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1117647003121	dimerization interface [polypeptide binding]; other site
1117647003122	putative ATP binding site [chemical binding]; other site
1117647003123	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1117647003124	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1117647003125	active site
1117647003126	substrate binding site [chemical binding]; other site
1117647003127	cosubstrate binding site; other site
1117647003128	catalytic site [active]
1117647003129	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
1117647003130	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
1117647003131	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1117647003132	Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848
1117647003133	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
1117647003134	NapD protein; Region: NapD; pfam03927
1117647003135	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
1117647003136	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1117647003137	[4Fe-4S] binding site [ion binding]; other site
1117647003138	molybdopterin cofactor binding site; other site
1117647003139	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1117647003140	molybdopterin cofactor binding site; other site
1117647003141	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
1117647003142	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
1117647003143	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
1117647003144	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
1117647003145	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1117647003146	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
1117647003147	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1117647003148	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1117647003149	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1117647003150	interface (dimer of trimers) [polypeptide binding]; other site
1117647003151	Substrate-binding/catalytic site; other site
1117647003152	Zn-binding sites [ion binding]; other site
1117647003153	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
1117647003154	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1117647003155	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1117647003156	HIGH motif; other site
1117647003157	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1117647003158	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1117647003159	active site
1117647003160	KMSKS motif; other site
1117647003161	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1117647003162	tRNA binding surface [nucleotide binding]; other site
1117647003163	anticodon binding site; other site
1117647003164	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1117647003165	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1117647003166	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1117647003167	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
1117647003168	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647003169	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647003170	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
1117647003171	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1117647003172	Walker A motif; other site
1117647003173	ATP binding site [chemical binding]; other site
1117647003174	Walker B motif; other site
1117647003175	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
1117647003176	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1117647003177	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1117647003178	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1117647003179	Amidohydrolase; Region: Amidohydro_4; pfam13147
1117647003180	active site
1117647003181	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1117647003182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647003183	active site
1117647003184	phosphorylation site [posttranslational modification]
1117647003185	intermolecular recognition site; other site
1117647003186	dimerization interface [polypeptide binding]; other site
1117647003187	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1117647003188	DNA binding residues [nucleotide binding]
1117647003189	dimerization interface [polypeptide binding]; other site
1117647003190	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1117647003191	Histidine kinase; Region: HisKA_3; pfam07730
1117647003192	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647003193	ATP binding site [chemical binding]; other site
1117647003194	Mg2+ binding site [ion binding]; other site
1117647003195	G-X-G motif; other site
1117647003196	Sensors of blue-light using FAD; Region: BLUF; pfam04940
1117647003197	EVE domain; Region: EVE; cl00728
1117647003198	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
1117647003199	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1117647003200	E3 interaction surface; other site
1117647003201	lipoyl attachment site [posttranslational modification]; other site
1117647003202	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1117647003203	E3 interaction surface; other site
1117647003204	lipoyl attachment site [posttranslational modification]; other site
1117647003205	e3 binding domain; Region: E3_binding; pfam02817
1117647003206	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1117647003207	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1117647003208	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1117647003209	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1117647003210	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
1117647003211	Peptidase family M48; Region: Peptidase_M48; cl12018
1117647003212	Protein of unknown function (DUF819); Region: DUF819; cl02317
1117647003213	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1117647003214	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647003215	binding surface
1117647003216	TPR motif; other site
1117647003217	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1117647003218	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1117647003219	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647003220	binding surface
1117647003221	TPR motif; other site
1117647003222	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1117647003223	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647003224	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647003225	metal binding site [ion binding]; metal-binding site
1117647003226	active site
1117647003227	I-site; other site
1117647003228	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1117647003229	Protein export membrane protein; Region: SecD_SecF; cl14618
1117647003230	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1117647003231	HlyD family secretion protein; Region: HlyD_3; pfam13437
1117647003232	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
1117647003233	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1117647003234	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1117647003235	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1117647003236	putative acyl-acceptor binding pocket; other site
1117647003237	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1117647003238	Protein of unknown function (DUF3549); Region: DUF3549; pfam12069
1117647003239	Beta-lactamase; Region: Beta-lactamase; cl17358
1117647003240	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647003241	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1117647003242	N-terminal plug; other site
1117647003243	ligand-binding site [chemical binding]; other site
1117647003244	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1117647003245	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
1117647003246	active site
1117647003247	catalytic triad [active]
1117647003248	dimer interface [polypeptide binding]; other site
1117647003249	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1117647003250	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1117647003251	DNA-binding site [nucleotide binding]; DNA binding site
1117647003252	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1117647003253	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647003254	homodimer interface [polypeptide binding]; other site
1117647003255	catalytic residue [active]
1117647003256	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647003257	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647003258	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
1117647003259	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1117647003260	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117647003261	active site
1117647003262	motif I; other site
1117647003263	motif II; other site
1117647003264	Cytochrome c; Region: Cytochrom_C; cl11414
1117647003265	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
1117647003266	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1117647003267	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1117647003268	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1117647003269	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
1117647003270	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
1117647003271	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1117647003272	dimerization interface [polypeptide binding]; other site
1117647003273	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117647003274	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647003275	dimer interface [polypeptide binding]; other site
1117647003276	phosphorylation site [posttranslational modification]
1117647003277	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647003278	ATP binding site [chemical binding]; other site
1117647003279	Mg2+ binding site [ion binding]; other site
1117647003280	G-X-G motif; other site
1117647003281	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647003282	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647003283	active site
1117647003284	phosphorylation site [posttranslational modification]
1117647003285	intermolecular recognition site; other site
1117647003286	dimerization interface [polypeptide binding]; other site
1117647003287	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
1117647003288	Protein of unknown function (DUF3581); Region: DUF3581; pfam12119
1117647003289	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1117647003290	putative active site pocket [active]
1117647003291	dimerization interface [polypeptide binding]; other site
1117647003292	putative catalytic residue [active]
1117647003293	Fic family protein [Function unknown]; Region: COG3177
1117647003294	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
1117647003295	Fic/DOC family; Region: Fic; pfam02661
1117647003296	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
1117647003297	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1117647003298	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117647003299	ATP binding site [chemical binding]; other site
1117647003300	putative Mg++ binding site [ion binding]; other site
1117647003301	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1117647003302	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1117647003303	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1117647003304	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1117647003305	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1117647003306	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
1117647003307	nucleotide binding site/active site [active]
1117647003308	HIT family signature motif; other site
1117647003309	catalytic residue [active]
1117647003310	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1117647003311	putative DNA binding site [nucleotide binding]; other site
1117647003312	putative Zn2+ binding site [ion binding]; other site
1117647003313	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1117647003314	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1117647003315	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1117647003316	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
1117647003317	calcium binding site 2 [ion binding]; other site
1117647003318	active site
1117647003319	catalytic triad [active]
1117647003320	calcium binding site 1 [ion binding]; other site
1117647003321	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1117647003322	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1117647003323	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1117647003324	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647003325	dimer interface [polypeptide binding]; other site
1117647003326	phosphorylation site [posttranslational modification]
1117647003327	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647003328	ATP binding site [chemical binding]; other site
1117647003329	Mg2+ binding site [ion binding]; other site
1117647003330	G-X-G motif; other site
1117647003331	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1117647003332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647003333	active site
1117647003334	phosphorylation site [posttranslational modification]
1117647003335	intermolecular recognition site; other site
1117647003336	dimerization interface [polypeptide binding]; other site
1117647003337	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1117647003338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647003339	active site
1117647003340	phosphorylation site [posttranslational modification]
1117647003341	intermolecular recognition site; other site
1117647003342	dimerization interface [polypeptide binding]; other site
1117647003343	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
1117647003344	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1117647003345	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1117647003346	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
1117647003347	active site
1117647003348	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1117647003349	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1117647003350	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1117647003351	Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743
1117647003352	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1117647003353	bile acid transporter; Region: bass; TIGR00841
1117647003354	Sodium Bile acid symporter family; Region: SBF; cl17470
1117647003355	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
1117647003356	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1117647003357	putative NAD(P) binding site [chemical binding]; other site
1117647003358	active site
1117647003359	putative substrate binding site [chemical binding]; other site
1117647003360	short chain dehydrogenase; Provisional; Region: PRK06181
1117647003361	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117647003362	NAD(P) binding site [chemical binding]; other site
1117647003363	active site
1117647003364	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1117647003365	active site
1117647003366	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1117647003367	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1117647003368	active site
1117647003369	ATP binding site [chemical binding]; other site
1117647003370	substrate binding site [chemical binding]; other site
1117647003371	activation loop (A-loop); other site
1117647003372	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
1117647003373	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647003374	putative substrate translocation pore; other site
1117647003375	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647003376	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
1117647003377	nitrite reductase subunit NirD; Provisional; Region: PRK14989
1117647003378	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1117647003379	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1117647003380	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1117647003381	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1117647003382	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
1117647003383	active site
1117647003384	SAM binding site [chemical binding]; other site
1117647003385	homodimer interface [polypeptide binding]; other site
1117647003386	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1117647003387	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1117647003388	[4Fe-4S] binding site [ion binding]; other site
1117647003389	molybdopterin cofactor binding site; other site
1117647003390	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1117647003391	molybdopterin cofactor binding site; other site
1117647003392	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
1117647003393	4Fe-4S binding domain; Region: Fer4; pfam00037
1117647003394	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
1117647003395	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
1117647003396	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1117647003397	FeS/SAM binding site; other site
1117647003398	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1117647003399	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
1117647003400	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1117647003401	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
1117647003402	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
1117647003403	putative active site [active]
1117647003404	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
1117647003405	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1117647003406	Glyco_18 domain; Region: Glyco_18; smart00636
1117647003407	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
1117647003408	active site
1117647003409	Lipase (class 2); Region: Lipase_2; pfam01674
1117647003410	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1117647003411	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1117647003412	Amidase; Region: Amidase; cl11426
1117647003413	short chain dehydrogenase; Provisional; Region: PRK07576
1117647003414	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
1117647003415	NAD(P) binding site [chemical binding]; other site
1117647003416	substrate binding site [chemical binding]; other site
1117647003417	homotetramer interface [polypeptide binding]; other site
1117647003418	active site
1117647003419	homodimer interface [polypeptide binding]; other site
1117647003420	enoyl-CoA hydratase; Provisional; Region: PRK06688
1117647003421	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1117647003422	substrate binding site [chemical binding]; other site
1117647003423	oxyanion hole (OAH) forming residues; other site
1117647003424	trimer interface [polypeptide binding]; other site
1117647003425	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1117647003426	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1117647003427	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1117647003428	dimerization interface [polypeptide binding]; other site
1117647003429	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1117647003430	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1117647003431	dimer interface [polypeptide binding]; other site
1117647003432	putative CheW interface [polypeptide binding]; other site
1117647003433	C factor cell-cell signaling protein; Provisional; Region: PRK09009
1117647003434	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
1117647003435	NADP binding site [chemical binding]; other site
1117647003436	homodimer interface [polypeptide binding]; other site
1117647003437	active site
1117647003438	VanZ like family; Region: VanZ; cl01971
1117647003439	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
1117647003440	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
1117647003441	Thrombospondin type 3 repeat; Region: TSP_3; pfam02412
1117647003442	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1117647003443	dimerization interface [polypeptide binding]; other site
1117647003444	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647003445	dimer interface [polypeptide binding]; other site
1117647003446	phosphorylation site [posttranslational modification]
1117647003447	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647003448	ATP binding site [chemical binding]; other site
1117647003449	Mg2+ binding site [ion binding]; other site
1117647003450	G-X-G motif; other site
1117647003451	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1117647003452	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647003453	active site
1117647003454	phosphorylation site [posttranslational modification]
1117647003455	intermolecular recognition site; other site
1117647003456	dimerization interface [polypeptide binding]; other site
1117647003457	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1117647003458	DNA binding site [nucleotide binding]
1117647003459	Spondin_N; Region: Spond_N; pfam06468
1117647003460	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
1117647003461	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1117647003462	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1117647003463	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1117647003464	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
1117647003465	aspartate racemase; Region: asp_race; TIGR00035
1117647003466	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
1117647003467	siderophore ferric iron reductase, AHA_1954 family; Region: sidero_Fe_reduc; TIGR03950
1117647003468	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1117647003469	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
1117647003470	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1117647003471	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1117647003472	serine/threonine transporter SstT; Provisional; Region: PRK13628
1117647003473	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1117647003474	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1117647003475	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117647003476	Walker A/P-loop; other site
1117647003477	ATP binding site [chemical binding]; other site
1117647003478	Q-loop/lid; other site
1117647003479	ABC transporter signature motif; other site
1117647003480	Walker B; other site
1117647003481	D-loop; other site
1117647003482	H-loop/switch region; other site
1117647003483	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1117647003484	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1117647003485	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647003486	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647003487	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647003488	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647003489	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1117647003490	N-terminal plug; other site
1117647003491	ligand-binding site [chemical binding]; other site
1117647003492	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
1117647003493	FecR protein; Region: FecR; pfam04773
1117647003494	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1117647003495	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117647003496	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1117647003497	DNA binding residues [nucleotide binding]
1117647003498	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1117647003499	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117647003500	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1117647003501	dimerization interface [polypeptide binding]; other site
1117647003502	substrate binding pocket [chemical binding]; other site
1117647003503	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1117647003504	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1117647003505	NAD binding site [chemical binding]; other site
1117647003506	catalytic residues [active]
1117647003507	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
1117647003508	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
1117647003509	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
1117647003510	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
1117647003511	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1117647003512	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1117647003513	substrate-cofactor binding pocket; other site
1117647003514	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647003515	catalytic residue [active]
1117647003516	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
1117647003517	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1117647003518	NAD(P) binding site [chemical binding]; other site
1117647003519	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1117647003520	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1117647003521	non-specific DNA binding site [nucleotide binding]; other site
1117647003522	salt bridge; other site
1117647003523	sequence-specific DNA binding site [nucleotide binding]; other site
1117647003524	Cupin domain; Region: Cupin_2; pfam07883
1117647003525	glycine dehydrogenase; Provisional; Region: PRK05367
1117647003526	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1117647003527	tetramer interface [polypeptide binding]; other site
1117647003528	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647003529	catalytic residue [active]
1117647003530	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1117647003531	tetramer interface [polypeptide binding]; other site
1117647003532	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647003533	catalytic residue [active]
1117647003534	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1117647003535	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1117647003536	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1117647003537	ABC transporter; Region: ABC_tran_2; pfam12848
1117647003538	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1117647003539	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1117647003540	Interdomain contacts; other site
1117647003541	Cytokine receptor motif; other site
1117647003542	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
1117647003543	PA14 domain; Region: PA14; cl08459
1117647003544	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1117647003545	Interdomain contacts; other site
1117647003546	Cytokine receptor motif; other site
1117647003547	PA14 domain; Region: PA14; cl08459
1117647003548	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1117647003549	SnoaL-like domain; Region: SnoaL_2; pfam12680
1117647003550	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1117647003551	Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080
1117647003552	Ca binding site [ion binding]; other site
1117647003553	ligand binding site I [chemical binding]; other site
1117647003554	homodimer interface [polypeptide binding]; other site
1117647003555	ligand binding site II [chemical binding]; other site
1117647003556	Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080
1117647003557	Ca binding site [ion binding]; other site
1117647003558	ligand binding site I [chemical binding]; other site
1117647003559	homodimer interface [polypeptide binding]; other site
1117647003560	ligand binding site II [chemical binding]; other site
1117647003561	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1117647003562	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1117647003563	putative sugar binding sites [chemical binding]; other site
1117647003564	Q-X-W motif; other site
1117647003565	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1117647003566	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1117647003567	Interdomain contacts; other site
1117647003568	Cytokine receptor motif; other site
1117647003569	Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080
1117647003570	Ca binding site [ion binding]; other site
1117647003571	ligand binding site I [chemical binding]; other site
1117647003572	homodimer interface [polypeptide binding]; other site
1117647003573	ligand binding site II [chemical binding]; other site
1117647003574	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647003575	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647003576	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1117647003577	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1117647003578	RNA binding surface [nucleotide binding]; other site
1117647003579	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1117647003580	active site
1117647003581	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1117647003582	CoenzymeA binding site [chemical binding]; other site
1117647003583	subunit interaction site [polypeptide binding]; other site
1117647003584	PHB binding site; other site
1117647003585	carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376
1117647003586	starch binding site [chemical binding]; other site
1117647003587	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
1117647003588	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
1117647003589	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
1117647003590	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1117647003591	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1117647003592	active site
1117647003593	catalytic site [active]
1117647003594	Putative phosphatase regulatory subunit; Region: CBM_21; pfam03370
1117647003595	Putative phosphatase regulatory subunit; Region: CBM_21; pfam03370
1117647003596	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
1117647003597	PilZ domain; Region: PilZ; pfam07238
1117647003598	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
1117647003599	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
1117647003600	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1117647003601	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
1117647003602	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1117647003603	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
1117647003604	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647003605	active site
1117647003606	phosphorylation site [posttranslational modification]
1117647003607	intermolecular recognition site; other site
1117647003608	dimerization interface [polypeptide binding]; other site
1117647003609	LytTr DNA-binding domain; Region: LytTR; smart00850
1117647003610	Family description; Region: VCBS; pfam13517
1117647003611	Family description; Region: VCBS; pfam13517
1117647003612	Family description; Region: VCBS; pfam13517
1117647003613	Family description; Region: VCBS; pfam13517
1117647003614	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647003615	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647003616	metal binding site [ion binding]; metal-binding site
1117647003617	active site
1117647003618	I-site; other site
1117647003619	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1117647003620	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1117647003621	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1117647003622	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1117647003623	molybdopterin cofactor binding site; other site
1117647003624	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1117647003625	putative molybdopterin cofactor binding site; other site
1117647003626	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647003627	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1117647003628	N-terminal plug; other site
1117647003629	ligand-binding site [chemical binding]; other site
1117647003630	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
1117647003631	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117647003632	ATP binding site [chemical binding]; other site
1117647003633	putative Mg++ binding site [ion binding]; other site
1117647003634	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117647003635	nucleotide binding region [chemical binding]; other site
1117647003636	ATP-binding site [chemical binding]; other site
1117647003637	Helicase associated domain (HA2); Region: HA2; cl04503
1117647003638	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
1117647003639	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
1117647003640	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1117647003641	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
1117647003642	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
1117647003643	active site
1117647003644	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315
1117647003645	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
1117647003646	active site
1117647003647	Ca binding site [ion binding]; other site
1117647003648	catalytic site [active]
1117647003649	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1117647003650	nudix motif; other site
1117647003651	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1117647003652	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1117647003653	Methyltransferase domain; Region: Methyltransf_32; pfam13679
1117647003654	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647003655	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647003656	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
1117647003657	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1117647003658	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1117647003659	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1117647003660	arginine decarboxylase; Provisional; Region: PRK05354
1117647003661	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
1117647003662	dimer interface [polypeptide binding]; other site
1117647003663	active site
1117647003664	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1117647003665	catalytic residues [active]
1117647003666	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1117647003667	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
1117647003668	universal stress protein UspE; Provisional; Region: PRK11175
1117647003669	Universal stress protein family; Region: Usp; pfam00582
1117647003670	Ligand Binding Site [chemical binding]; other site
1117647003671	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1117647003672	Ligand Binding Site [chemical binding]; other site
1117647003673	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
1117647003674	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
1117647003675	putative metal binding site [ion binding]; other site
1117647003676	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1117647003677	HSP70 interaction site [polypeptide binding]; other site
1117647003678	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1117647003679	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
1117647003680	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1117647003681	PYR/PP interface [polypeptide binding]; other site
1117647003682	dimer interface [polypeptide binding]; other site
1117647003683	TPP binding site [chemical binding]; other site
1117647003684	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1117647003685	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1117647003686	TPP-binding site [chemical binding]; other site
1117647003687	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1117647003688	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1117647003689	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1117647003690	DNA binding residues [nucleotide binding]
1117647003691	dimerization interface [polypeptide binding]; other site
1117647003692	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1117647003693	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1117647003694	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1117647003695	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1117647003696	DNA binding residues [nucleotide binding]
1117647003697	dimerization interface [polypeptide binding]; other site
1117647003698	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1117647003699	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1117647003700	DNA-binding site [nucleotide binding]; DNA binding site
1117647003701	FCD domain; Region: FCD; pfam07729
1117647003702	putative aminotransferase; Validated; Region: PRK07480
1117647003703	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1117647003704	inhibitor-cofactor binding pocket; inhibition site
1117647003705	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647003706	catalytic residue [active]
1117647003707	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
1117647003708	YceI-like domain; Region: YceI; pfam04264
1117647003709	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
1117647003710	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1117647003711	dimer interface [polypeptide binding]; other site
1117647003712	active site
1117647003713	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1117647003714	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117647003715	NAD(P) binding site [chemical binding]; other site
1117647003716	active site
1117647003717	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
1117647003718	putative active site 1 [active]
1117647003719	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
1117647003720	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1117647003721	dimer interface [polypeptide binding]; other site
1117647003722	active site
1117647003723	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1117647003724	Protein of unknown function (DUF3261); Region: DUF3261; pfam11659
1117647003725	O-methyltransferase; Region: Methyltransf_2; pfam00891
1117647003726	Predicted exporter [General function prediction only]; Region: COG4258
1117647003727	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1117647003728	active site
1117647003729	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1117647003730	active sites [active]
1117647003731	tetramer interface [polypeptide binding]; other site
1117647003732	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1117647003733	Ligand binding site; other site
1117647003734	Putative Catalytic site; other site
1117647003735	DXD motif; other site
1117647003736	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1117647003737	active site 2 [active]
1117647003738	active site 1 [active]
1117647003739	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1117647003740	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1117647003741	acyl-activating enzyme (AAE) consensus motif; other site
1117647003742	AMP binding site [chemical binding]; other site
1117647003743	active site
1117647003744	CoA binding site [chemical binding]; other site
1117647003745	Predicted membrane protein [Function unknown]; Region: COG4648
1117647003746	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1117647003747	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1117647003748	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1117647003749	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1117647003750	putative acyl-acceptor binding pocket; other site
1117647003751	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
1117647003752	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1117647003753	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1117647003754	Protein of unknown function, DUF486; Region: DUF486; pfam04342
1117647003755	MgtC family; Region: MgtC; pfam02308
1117647003756	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1117647003757	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
1117647003758	dimer interface [polypeptide binding]; other site
1117647003759	active site
1117647003760	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1117647003761	catalytic residues [active]
1117647003762	substrate binding site [chemical binding]; other site
1117647003763	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
1117647003764	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1117647003765	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
1117647003766	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1117647003767	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1117647003768	FeS/SAM binding site; other site
1117647003769	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1117647003770	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
1117647003771	active site
1117647003772	catalytic site [active]
1117647003773	metal binding site [ion binding]; metal-binding site
1117647003774	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1117647003775	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117647003776	Coenzyme A binding pocket [chemical binding]; other site
1117647003777	lipoyl synthase; Provisional; Region: PRK05481
1117647003778	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1117647003779	FeS/SAM binding site; other site
1117647003780	lipoate-protein ligase B; Provisional; Region: PRK14342
1117647003781	Protein of unknown function (DUF493); Region: DUF493; pfam04359
1117647003782	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1117647003783	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1117647003784	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1117647003785	rare lipoprotein A; Region: rlpA; TIGR00413
1117647003786	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1117647003787	Sporulation related domain; Region: SPOR; pfam05036
1117647003788	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1117647003789	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1117647003790	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1117647003791	catalytic residue [active]
1117647003792	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1117647003793	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1117647003794	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1117647003795	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1117647003796	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1117647003797	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1117647003798	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1117647003799	putative catalytic cysteine [active]
1117647003800	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
1117647003801	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
1117647003802	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1117647003803	phosphopeptide binding site; other site
1117647003804	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1117647003805	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1117647003806	phosphopeptide binding site; other site
1117647003807	glycerate dehydrogenase; Provisional; Region: PRK06487
1117647003808	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
1117647003809	putative ligand binding site [chemical binding]; other site
1117647003810	putative NAD binding site [chemical binding]; other site
1117647003811	catalytic site [active]
1117647003812	Protein phosphatase 2C; Region: PP2C; pfam00481
1117647003813	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1117647003814	active site
1117647003815	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
1117647003816	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1117647003817	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1117647003818	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1117647003819	6-phosphofructokinase; Provisional; Region: PRK14072
1117647003820	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1117647003821	active site
1117647003822	ADP/pyrophosphate binding site [chemical binding]; other site
1117647003823	dimerization interface [polypeptide binding]; other site
1117647003824	allosteric effector site; other site
1117647003825	fructose-1,6-bisphosphate binding site; other site
1117647003826	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
1117647003827	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1117647003828	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647003829	putative active site [active]
1117647003830	heme pocket [chemical binding]; other site
1117647003831	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1117647003832	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647003833	putative active site [active]
1117647003834	heme pocket [chemical binding]; other site
1117647003835	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647003836	dimer interface [polypeptide binding]; other site
1117647003837	phosphorylation site [posttranslational modification]
1117647003838	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647003839	ATP binding site [chemical binding]; other site
1117647003840	Mg2+ binding site [ion binding]; other site
1117647003841	G-X-G motif; other site
1117647003842	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647003843	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647003844	active site
1117647003845	phosphorylation site [posttranslational modification]
1117647003846	intermolecular recognition site; other site
1117647003847	dimerization interface [polypeptide binding]; other site
1117647003848	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647003849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647003850	active site
1117647003851	phosphorylation site [posttranslational modification]
1117647003852	intermolecular recognition site; other site
1117647003853	dimerization interface [polypeptide binding]; other site
1117647003854	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1117647003855	putative binding surface; other site
1117647003856	active site
1117647003857	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
1117647003858	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
1117647003859	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1117647003860	dimer interface [polypeptide binding]; other site
1117647003861	substrate binding site [chemical binding]; other site
1117647003862	metal binding sites [ion binding]; metal-binding site
1117647003863	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
1117647003864	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
1117647003865	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
1117647003866	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
1117647003867	serine acetyltransferase; Provisional; Region: cysE; PRK11132
1117647003868	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
1117647003869	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1117647003870	trimer interface [polypeptide binding]; other site
1117647003871	active site
1117647003872	substrate binding site [chemical binding]; other site
1117647003873	CoA binding site [chemical binding]; other site
1117647003874	6-phosphogluconate phosphatase; Provisional; Region: PRK10563
1117647003875	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1117647003876	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1117647003877	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117647003878	motif II; other site
1117647003879	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1117647003880	TfoX C-terminal domain; Region: TfoX_C; pfam04994
1117647003881	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1117647003882	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1117647003883	ligand binding site [chemical binding]; other site
1117647003884	flexible hinge region; other site
1117647003885	heat shock protein HtpX; Provisional; Region: PRK05457
1117647003886	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1117647003887	iron-sulfur cluster [ion binding]; other site
1117647003888	[2Fe-2S] cluster binding site [ion binding]; other site
1117647003889	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
1117647003890	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
1117647003891	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
1117647003892	active site
1117647003893	HIGH motif; other site
1117647003894	nucleotide binding site [chemical binding]; other site
1117647003895	KMSKS motif; other site
1117647003896	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1117647003897	Na binding site [ion binding]; other site
1117647003898	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1117647003899	PAS domain; Region: PAS; smart00091
1117647003900	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647003901	dimer interface [polypeptide binding]; other site
1117647003902	phosphorylation site [posttranslational modification]
1117647003903	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647003904	ATP binding site [chemical binding]; other site
1117647003905	Mg2+ binding site [ion binding]; other site
1117647003906	G-X-G motif; other site
1117647003907	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1117647003908	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647003909	active site
1117647003910	phosphorylation site [posttranslational modification]
1117647003911	intermolecular recognition site; other site
1117647003912	dimerization interface [polypeptide binding]; other site
1117647003913	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647003914	Walker A motif; other site
1117647003915	ATP binding site [chemical binding]; other site
1117647003916	Walker B motif; other site
1117647003917	arginine finger; other site
1117647003918	poly(A) polymerase; Region: pcnB; TIGR01942
1117647003919	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1117647003920	active site
1117647003921	NTP binding site [chemical binding]; other site
1117647003922	metal binding triad [ion binding]; metal-binding site
1117647003923	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1117647003924	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
1117647003925	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1117647003926	catalytic center binding site [active]
1117647003927	ATP binding site [chemical binding]; other site
1117647003928	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1117647003929	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1117647003930	Substrate-binding site [chemical binding]; other site
1117647003931	Substrate specificity [chemical binding]; other site
1117647003932	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1117647003933	oligomerization interface [polypeptide binding]; other site
1117647003934	active site
1117647003935	metal binding site [ion binding]; metal-binding site
1117647003936	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
1117647003937	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
1117647003938	DTW domain; Region: DTW; cl01221
1117647003939	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1117647003940	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1117647003941	RNase E interface [polypeptide binding]; other site
1117647003942	trimer interface [polypeptide binding]; other site
1117647003943	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1117647003944	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1117647003945	RNase E interface [polypeptide binding]; other site
1117647003946	trimer interface [polypeptide binding]; other site
1117647003947	active site
1117647003948	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1117647003949	putative nucleic acid binding region [nucleotide binding]; other site
1117647003950	G-X-X-G motif; other site
1117647003951	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1117647003952	RNA binding site [nucleotide binding]; other site
1117647003953	domain interface; other site
1117647003954	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1117647003955	16S/18S rRNA binding site [nucleotide binding]; other site
1117647003956	S13e-L30e interaction site [polypeptide binding]; other site
1117647003957	25S rRNA binding site [nucleotide binding]; other site
1117647003958	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
1117647003959	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1117647003960	RNA binding site [nucleotide binding]; other site
1117647003961	active site
1117647003962	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
1117647003963	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1117647003964	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1117647003965	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
1117647003966	translation initiation factor IF-2; Region: IF-2; TIGR00487
1117647003967	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1117647003968	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1117647003969	G1 box; other site
1117647003970	putative GEF interaction site [polypeptide binding]; other site
1117647003971	GTP/Mg2+ binding site [chemical binding]; other site
1117647003972	Switch I region; other site
1117647003973	G2 box; other site
1117647003974	G3 box; other site
1117647003975	Switch II region; other site
1117647003976	G4 box; other site
1117647003977	G5 box; other site
1117647003978	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1117647003979	Translation-initiation factor 2; Region: IF-2; pfam11987
1117647003980	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1117647003981	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
1117647003982	NusA N-terminal domain; Region: NusA_N; pfam08529
1117647003983	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1117647003984	RNA binding site [nucleotide binding]; other site
1117647003985	homodimer interface [polypeptide binding]; other site
1117647003986	NusA-like KH domain; Region: KH_5; pfam13184
1117647003987	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1117647003988	G-X-X-G motif; other site
1117647003989	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1117647003990	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1117647003991	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1117647003992	Sm and related proteins; Region: Sm_like; cl00259
1117647003993	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1117647003994	putative oligomer interface [polypeptide binding]; other site
1117647003995	putative RNA binding site [nucleotide binding]; other site
1117647003996	Preprotein translocase SecG subunit; Region: SecG; pfam03840
1117647003997	triosephosphate isomerase; Provisional; Region: PRK14567
1117647003998	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1117647003999	substrate binding site [chemical binding]; other site
1117647004000	dimer interface [polypeptide binding]; other site
1117647004001	catalytic triad [active]
1117647004002	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
1117647004003	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1117647004004	active site
1117647004005	substrate binding site [chemical binding]; other site
1117647004006	metal binding site [ion binding]; metal-binding site
1117647004007	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1117647004008	dihydropteroate synthase; Region: DHPS; TIGR01496
1117647004009	substrate binding pocket [chemical binding]; other site
1117647004010	dimer interface [polypeptide binding]; other site
1117647004011	inhibitor binding site; inhibition site
1117647004012	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
1117647004013	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647004014	Walker A motif; other site
1117647004015	ATP binding site [chemical binding]; other site
1117647004016	Walker B motif; other site
1117647004017	arginine finger; other site
1117647004018	Peptidase family M41; Region: Peptidase_M41; pfam01434
1117647004019	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985
1117647004020	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
1117647004021	putative deacylase active site [active]
1117647004022	hypothetical protein; Provisional; Region: PRK09256
1117647004023	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1117647004024	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1117647004025	trimer interface [polypeptide binding]; other site
1117647004026	active site
1117647004027	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
1117647004028	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
1117647004029	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
1117647004030	Ion channel; Region: Ion_trans_2; pfam07885
1117647004031	Ion transport protein; Region: Ion_trans; pfam00520
1117647004032	Ion channel; Region: Ion_trans_2; pfam07885
1117647004033	antiporter inner membrane protein; Provisional; Region: PRK11670
1117647004034	Domain of unknown function DUF59; Region: DUF59; pfam01883
1117647004035	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1117647004036	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
1117647004037	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1117647004038	active site
1117647004039	HIGH motif; other site
1117647004040	KMSKS motif; other site
1117647004041	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1117647004042	tRNA binding surface [nucleotide binding]; other site
1117647004043	anticodon binding site; other site
1117647004044	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1117647004045	dimer interface [polypeptide binding]; other site
1117647004046	putative tRNA-binding site [nucleotide binding]; other site
1117647004047	electron transport complex protein RsxA; Provisional; Region: PRK05151
1117647004048	ferredoxin; Provisional; Region: PRK08764
1117647004049	Putative Fe-S cluster; Region: FeS; pfam04060
1117647004050	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1117647004051	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
1117647004052	FMN-binding domain; Region: FMN_bind; cl01081
1117647004053	electron transport complex RsxE subunit; Provisional; Region: PRK12405
1117647004054	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
1117647004055	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647004056	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647004057	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647004058	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647004059	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1117647004060	substrate binding pocket [chemical binding]; other site
1117647004061	membrane-bound complex binding site; other site
1117647004062	hinge residues; other site
1117647004063	Cytochrome c; Region: Cytochrom_C; cl11414
1117647004064	Cytochrome c; Region: Cytochrom_C; cl11414
1117647004065	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
1117647004066	parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805
1117647004067	Cytochrome c; Region: Cytochrom_C; cl11414
1117647004068	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1117647004069	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
1117647004070	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1117647004071	putative active site [active]
1117647004072	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493
1117647004073	Na binding site [ion binding]; other site
1117647004074	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
1117647004075	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
1117647004076	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
1117647004077	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1117647004078	putative active site [active]
1117647004079	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1117647004080	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1117647004081	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
1117647004082	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1117647004083	Cysteine-rich domain; Region: CCG; pfam02754
1117647004084	Cysteine-rich domain; Region: CCG; pfam02754
1117647004085	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
1117647004086	FAD binding domain; Region: FAD_binding_4; pfam01565
1117647004087	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
1117647004088	FAD binding domain; Region: FAD_binding_4; pfam01565
1117647004089	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
1117647004090	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
1117647004091	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1117647004092	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1117647004093	active site
1117647004094	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1117647004095	substrate binding site [chemical binding]; other site
1117647004096	catalytic residues [active]
1117647004097	dimer interface [polypeptide binding]; other site
1117647004098	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
1117647004099	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
1117647004100	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
1117647004101	dimer interface [polypeptide binding]; other site
1117647004102	catalytic triad [active]
1117647004103	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1117647004104	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
1117647004105	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1117647004106	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1117647004107	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
1117647004108	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1117647004109	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1117647004110	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1117647004111	putative active site [active]
1117647004112	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1117647004113	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
1117647004114	active site
1117647004115	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
1117647004116	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1117647004117	NlpC/P60 family; Region: NLPC_P60; cl17555
1117647004118	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
1117647004119	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647004120	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1117647004121	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1117647004122	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1117647004123	amidase catalytic site [active]
1117647004124	Zn binding residues [ion binding]; other site
1117647004125	substrate binding site [chemical binding]; other site
1117647004126	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
1117647004127	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1117647004128	Active site serine [active]
1117647004129	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1117647004130	Amidase; Region: Amidase; cl11426
1117647004131	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1117647004132	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117647004133	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1117647004134	dimerization interface [polypeptide binding]; other site
1117647004135	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1117647004136	NlpC/P60 family; Region: NLPC_P60; cl17555
1117647004137	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1117647004138	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
1117647004139	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1117647004140	Beta-lactamase; Region: Beta-lactamase; pfam00144
1117647004141	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1117647004142	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1117647004143	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
1117647004144	putative active site [active]
1117647004145	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
1117647004146	putative active site [active]
1117647004147	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
1117647004148	putative active site [active]
1117647004149	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647004150	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1117647004151	N-terminal plug; other site
1117647004152	ligand-binding site [chemical binding]; other site
1117647004153	Domain of unknown function (DUF3943); Region: DUF3943; pfam13084
1117647004154	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1117647004155	EamA-like transporter family; Region: EamA; pfam00892
1117647004156	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1117647004157	dimer interface [polypeptide binding]; other site
1117647004158	putative radical transfer pathway; other site
1117647004159	diiron center [ion binding]; other site
1117647004160	tyrosyl radical; other site
1117647004161	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647004162	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647004163	active site
1117647004164	phosphorylation site [posttranslational modification]
1117647004165	intermolecular recognition site; other site
1117647004166	dimerization interface [polypeptide binding]; other site
1117647004167	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647004168	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647004169	metal binding site [ion binding]; metal-binding site
1117647004170	active site
1117647004171	I-site; other site
1117647004172	YhhN-like protein; Region: YhhN; pfam07947
1117647004173	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
1117647004174	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
1117647004175	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1117647004176	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1117647004177	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647004178	S-adenosylmethionine binding site [chemical binding]; other site
1117647004179	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
1117647004180	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
1117647004181	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1117647004182	short chain dehydrogenase; Provisional; Region: PRK06101
1117647004183	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117647004184	NAD(P) binding site [chemical binding]; other site
1117647004185	active site
1117647004186	SnoaL-like domain; Region: SnoaL_2; pfam12680
1117647004187	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
1117647004188	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
1117647004189	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1117647004190	CoenzymeA binding site [chemical binding]; other site
1117647004191	subunit interaction site [polypeptide binding]; other site
1117647004192	PHB binding site; other site
1117647004193	Yip1 domain; Region: Yip1; cl17815
1117647004194	Family description; Region: DsbD_2; pfam13386
1117647004195	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
1117647004196	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
1117647004197	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1117647004198	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1117647004199	metal-binding site [ion binding]
1117647004200	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1117647004201	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1117647004202	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
1117647004203	FixH; Region: FixH; pfam05751
1117647004204	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
1117647004205	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1117647004206	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1117647004207	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
1117647004208	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
1117647004209	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1117647004210	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1117647004211	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
1117647004212	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
1117647004213	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
1117647004214	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
1117647004215	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
1117647004216	Low-spin heme binding site [chemical binding]; other site
1117647004217	Putative water exit pathway; other site
1117647004218	Binuclear center (active site) [active]
1117647004219	Putative proton exit pathway; other site
1117647004220	argininosuccinate synthase; Provisional; Region: PRK13820
1117647004221	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1117647004222	ANP binding site [chemical binding]; other site
1117647004223	Substrate Binding Site II [chemical binding]; other site
1117647004224	Substrate Binding Site I [chemical binding]; other site
1117647004225	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1117647004226	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1117647004227	ligand binding site [chemical binding]; other site
1117647004228	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
1117647004229	active site
1117647004230	substrate binding pocket [chemical binding]; other site
1117647004231	dimer interface [polypeptide binding]; other site
1117647004232	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1117647004233	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
1117647004234	dimer interface [polypeptide binding]; other site
1117647004235	catalytic site [active]
1117647004236	putative active site [active]
1117647004237	putative substrate binding site [chemical binding]; other site
1117647004238	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
1117647004239	Ca2+ binding site [ion binding]; other site
1117647004240	aspartate carbamoyltransferase; Provisional; Region: PRK08192
1117647004241	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1117647004242	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1117647004243	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
1117647004244	exonuclease I; Provisional; Region: sbcB; PRK11779
1117647004245	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
1117647004246	active site
1117647004247	catalytic site [active]
1117647004248	substrate binding site [chemical binding]; other site
1117647004249	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
1117647004250	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
1117647004251	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647004252	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647004253	beta-D-glucuronidase; Provisional; Region: PRK10150
1117647004254	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1117647004255	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1117647004256	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1117647004257	Alginate lyase; Region: Alginate_lyase; pfam05426
1117647004258	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
1117647004259	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1117647004260	NADP binding site [chemical binding]; other site
1117647004261	homodimer interface [polypeptide binding]; other site
1117647004262	active site
1117647004263	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1117647004264	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
1117647004265	mannonate dehydratase; Provisional; Region: PRK03906
1117647004266	mannonate dehydratase; Region: uxuA; TIGR00695
1117647004267	glucuronate isomerase; Reviewed; Region: PRK02925
1117647004268	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
1117647004269	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1117647004270	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1117647004271	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1117647004272	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1117647004273	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1117647004274	DNA-binding site [nucleotide binding]; DNA binding site
1117647004275	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1117647004276	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1117647004277	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1117647004278	substrate binding site [chemical binding]; other site
1117647004279	ATP binding site [chemical binding]; other site
1117647004280	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1117647004281	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1117647004282	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1117647004283	DctM-like transporters; Region: DctM; pfam06808
1117647004284	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1117647004285	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
1117647004286	active site clefts [active]
1117647004287	zinc binding site [ion binding]; other site
1117647004288	dimer interface [polypeptide binding]; other site
1117647004289	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1117647004290	Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560
1117647004291	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
1117647004292	putative active site [active]
1117647004293	catalytic site [active]
1117647004294	putative metal binding site [ion binding]; other site
1117647004295	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
1117647004296	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1117647004297	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117647004298	ATP binding site [chemical binding]; other site
1117647004299	putative Mg++ binding site [ion binding]; other site
1117647004300	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1117647004301	hypothetical protein; Provisional; Region: PRK12378
1117647004302	putative fumarate hydratase; Provisional; Region: PRK15392
1117647004303	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
1117647004304	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1117647004305	superoxide dismutase; Provisional; Region: PRK10543
1117647004306	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1117647004307	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1117647004308	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
1117647004309	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
1117647004310	Flavoprotein; Region: Flavoprotein; pfam02441
1117647004311	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1117647004312	Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317
1117647004313	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
1117647004314	active site
1117647004315	Ca binding site [ion binding]; other site
1117647004316	catalytic site [active]
1117647004317	Aamy_C domain; Region: Aamy_C; smart00632
1117647004318	carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376
1117647004319	starch binding site [chemical binding]; other site
1117647004320	carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956
1117647004321	starch binding site [chemical binding]; other site
1117647004322	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647004323	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1117647004324	N-terminal plug; other site
1117647004325	ligand-binding site [chemical binding]; other site
1117647004326	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1117647004327	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1117647004328	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1117647004329	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1117647004330	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1117647004331	HlyD family secretion protein; Region: HlyD_3; pfam13437
1117647004332	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1117647004333	Peptidase family M48; Region: Peptidase_M48; pfam01435
1117647004334	RDD family; Region: RDD; pfam06271
1117647004335	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
1117647004336	ligand binding site [chemical binding]; other site
1117647004337	active site
1117647004338	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647004339	dimer interface [polypeptide binding]; other site
1117647004340	phosphorylation site [posttranslational modification]
1117647004341	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647004342	ATP binding site [chemical binding]; other site
1117647004343	Mg2+ binding site [ion binding]; other site
1117647004344	G-X-G motif; other site
1117647004345	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1117647004346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647004347	active site
1117647004348	phosphorylation site [posttranslational modification]
1117647004349	intermolecular recognition site; other site
1117647004350	dimerization interface [polypeptide binding]; other site
1117647004351	MltA-interacting protein MipA; Region: MipA; cl01504
1117647004352	hypothetical protein; Provisional; Region: PRK10318
1117647004353	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117647004354	TIGR01777 family protein; Region: yfcH
1117647004355	NAD(P) binding site [chemical binding]; other site
1117647004356	active site
1117647004357	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647004358	S-adenosylmethionine binding site [chemical binding]; other site
1117647004359	HopJ type III effector protein; Region: HopJ; pfam08888
1117647004360	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
1117647004361	GIY-YIG motif/motif A; other site
1117647004362	active site
1117647004363	catalytic site [active]
1117647004364	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1117647004365	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117647004366	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1117647004367	dimerization interface [polypeptide binding]; other site
1117647004368	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
1117647004369	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1117647004370	FAD binding site [chemical binding]; other site
1117647004371	substrate binding pocket [chemical binding]; other site
1117647004372	catalytic base [active]
1117647004373	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1117647004374	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1117647004375	Flagellar protein YcgR; Region: YcgR_2; pfam12945
1117647004376	PilZ domain; Region: PilZ; pfam07238
1117647004377	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1117647004378	Protein export membrane protein; Region: SecD_SecF; cl14618
1117647004379	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1117647004380	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1117647004381	HlyD family secretion protein; Region: HlyD_3; pfam13437
1117647004382	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
1117647004383	active site residue [active]
1117647004384	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1117647004385	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1117647004386	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1117647004387	ligand binding site [chemical binding]; other site
1117647004388	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1117647004389	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1117647004390	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1117647004391	hypothetical protein; Validated; Region: PRK00029
1117647004392	HDOD domain; Region: HDOD; pfam08668
1117647004393	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
1117647004394	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
1117647004395	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1117647004396	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1117647004397	Predicted methyltransferase [General function prediction only]; Region: COG3897
1117647004398	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1117647004399	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1117647004400	hypothetical protein; Provisional; Region: PRK10621
1117647004401	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1117647004402	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1117647004403	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
1117647004404	putative acyl-acceptor binding pocket; other site
1117647004405	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
1117647004406	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1117647004407	putative acyl-acceptor binding pocket; other site
1117647004408	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
1117647004409	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1117647004410	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1117647004411	G1 box; other site
1117647004412	putative GEF interaction site [polypeptide binding]; other site
1117647004413	GTP/Mg2+ binding site [chemical binding]; other site
1117647004414	Switch I region; other site
1117647004415	G2 box; other site
1117647004416	G3 box; other site
1117647004417	Switch II region; other site
1117647004418	G4 box; other site
1117647004419	G5 box; other site
1117647004420	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1117647004421	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
1117647004422	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1117647004423	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
1117647004424	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117647004425	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1117647004426	dimerization interface [polypeptide binding]; other site
1117647004427	Protein of unknown function (DUF3302); Region: DUF3302; pfam11742
1117647004428	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1117647004429	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1117647004430	HlyD family secretion protein; Region: HlyD_3; pfam13437
1117647004431	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1117647004432	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1117647004433	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
1117647004434	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1117647004435	substrate binding site [chemical binding]; other site
1117647004436	oxyanion hole (OAH) forming residues; other site
1117647004437	trimer interface [polypeptide binding]; other site
1117647004438	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1117647004439	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1117647004440	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
1117647004441	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1117647004442	dimer interface [polypeptide binding]; other site
1117647004443	active site
1117647004444	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
1117647004445	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1117647004446	dimer interface [polypeptide binding]; other site
1117647004447	active site
1117647004448	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1117647004449	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117647004450	NAD(P) binding site [chemical binding]; other site
1117647004451	active site
1117647004452	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
1117647004453	putative active site [active]
1117647004454	putative catalytic site [active]
1117647004455	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1117647004456	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1117647004457	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1117647004458	active site
1117647004459	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1117647004460	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1117647004461	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1117647004462	non-specific DNA binding site [nucleotide binding]; other site
1117647004463	salt bridge; other site
1117647004464	sequence-specific DNA binding site [nucleotide binding]; other site
1117647004465	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1117647004466	catalytic core [active]
1117647004467	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1117647004468	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1117647004469	active site
1117647004470	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
1117647004471	Phosphotransferase enzyme family; Region: APH; pfam01636
1117647004472	putative active site [active]
1117647004473	putative substrate binding site [chemical binding]; other site
1117647004474	ATP binding site [chemical binding]; other site
1117647004475	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1117647004476	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
1117647004477	NAD(P) binding site [chemical binding]; other site
1117647004478	short chain dehydrogenase; Provisional; Region: PRK07035
1117647004479	classical (c) SDRs; Region: SDR_c; cd05233
1117647004480	NAD(P) binding site [chemical binding]; other site
1117647004481	active site
1117647004482	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1117647004483	classical (c) SDRs; Region: SDR_c; cd05233
1117647004484	NAD(P) binding site [chemical binding]; other site
1117647004485	active site
1117647004486	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_2; cd13149
1117647004487	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1117647004488	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117647004489	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647004490	ATP binding site [chemical binding]; other site
1117647004491	Mg2+ binding site [ion binding]; other site
1117647004492	G-X-G motif; other site
1117647004493	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
1117647004494	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647004495	active site
1117647004496	phosphorylation site [posttranslational modification]
1117647004497	intermolecular recognition site; other site
1117647004498	dimerization interface [polypeptide binding]; other site
1117647004499	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1117647004500	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1117647004501	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117647004502	Coenzyme A binding pocket [chemical binding]; other site
1117647004503	2-isopropylmalate synthase; Validated; Region: PRK00915
1117647004504	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1117647004505	active site
1117647004506	catalytic residues [active]
1117647004507	metal binding site [ion binding]; metal-binding site
1117647004508	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1117647004509	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1117647004510	MarR family; Region: MarR; pfam01047
1117647004511	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1117647004512	catalytic residues [active]
1117647004513	dimer interface [polypeptide binding]; other site
1117647004514	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1117647004515	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1117647004516	NAD synthetase; Provisional; Region: PRK13981
1117647004517	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
1117647004518	multimer interface [polypeptide binding]; other site
1117647004519	active site
1117647004520	catalytic triad [active]
1117647004521	protein interface 1 [polypeptide binding]; other site
1117647004522	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1117647004523	homodimer interface [polypeptide binding]; other site
1117647004524	NAD binding pocket [chemical binding]; other site
1117647004525	ATP binding pocket [chemical binding]; other site
1117647004526	Mg binding site [ion binding]; other site
1117647004527	active-site loop [active]
1117647004528	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647004529	dimer interface [polypeptide binding]; other site
1117647004530	phosphorylation site [posttranslational modification]
1117647004531	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647004532	ATP binding site [chemical binding]; other site
1117647004533	Mg2+ binding site [ion binding]; other site
1117647004534	G-X-G motif; other site
1117647004535	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1117647004536	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647004537	active site
1117647004538	phosphorylation site [posttranslational modification]
1117647004539	intermolecular recognition site; other site
1117647004540	dimerization interface [polypeptide binding]; other site
1117647004541	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647004542	Walker A motif; other site
1117647004543	ATP binding site [chemical binding]; other site
1117647004544	Walker B motif; other site
1117647004545	arginine finger; other site
1117647004546	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1117647004547	Type II transport protein GspH; Region: GspH; pfam12019
1117647004548	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
1117647004549	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
1117647004550	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1117647004551	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
1117647004552	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1117647004553	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
1117647004554	Type II transport protein GspH; Region: GspH; pfam12019
1117647004555	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1117647004556	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1117647004557	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
1117647004558	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1117647004559	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1117647004560	lipoprotein signal peptidase; Provisional; Region: PRK14787
1117647004561	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1117647004562	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1117647004563	active site
1117647004564	HIGH motif; other site
1117647004565	nucleotide binding site [chemical binding]; other site
1117647004566	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1117647004567	active site
1117647004568	KMSKS motif; other site
1117647004569	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1117647004570	tRNA binding surface [nucleotide binding]; other site
1117647004571	anticodon binding site; other site
1117647004572	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1117647004573	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1117647004574	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1117647004575	active site
1117647004576	Riboflavin kinase; Region: Flavokinase; pfam01687
1117647004577	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
1117647004578	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1117647004579	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1117647004580	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
1117647004581	Protein of unknown function (DUF3144); Region: DUF3144; pfam11342
1117647004582	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1117647004583	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1117647004584	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1117647004585	gamma-glutamyl kinase; Provisional; Region: PRK05429
1117647004586	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1117647004587	nucleotide binding site [chemical binding]; other site
1117647004588	homotetrameric interface [polypeptide binding]; other site
1117647004589	putative phosphate binding site [ion binding]; other site
1117647004590	putative allosteric binding site; other site
1117647004591	PUA domain; Region: PUA; pfam01472
1117647004592	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
1117647004593	GTP1/OBG; Region: GTP1_OBG; pfam01018
1117647004594	Obg GTPase; Region: Obg; cd01898
1117647004595	G1 box; other site
1117647004596	GTP/Mg2+ binding site [chemical binding]; other site
1117647004597	Switch I region; other site
1117647004598	G2 box; other site
1117647004599	G3 box; other site
1117647004600	Switch II region; other site
1117647004601	G4 box; other site
1117647004602	G5 box; other site
1117647004603	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1117647004604	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1117647004605	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1117647004606	substrate binding pocket [chemical binding]; other site
1117647004607	chain length determination region; other site
1117647004608	substrate-Mg2+ binding site; other site
1117647004609	catalytic residues [active]
1117647004610	aspartate-rich region 1; other site
1117647004611	active site lid residues [active]
1117647004612	aspartate-rich region 2; other site
1117647004613	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
1117647004614	active site 1 [active]
1117647004615	dimer interface [polypeptide binding]; other site
1117647004616	active site 2 [active]
1117647004617	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
1117647004618	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1117647004619	dimer interface [polypeptide binding]; other site
1117647004620	active site
1117647004621	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117647004622	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1117647004623	NAD(P) binding site [chemical binding]; other site
1117647004624	active site
1117647004625	putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916
1117647004626	GAF domain; Region: GAF; cl17456
1117647004627	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647004628	ATP binding site [chemical binding]; other site
1117647004629	Mg2+ binding site [ion binding]; other site
1117647004630	G-X-G motif; other site
1117647004631	PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915
1117647004632	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647004633	active site
1117647004634	phosphorylation site [posttranslational modification]
1117647004635	intermolecular recognition site; other site
1117647004636	Pleckstrin homology-like domain; Region: PH-like; cl17171
1117647004637	dimerization interface [polypeptide binding]; other site
1117647004638	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647004639	Walker A motif; other site
1117647004640	ATP binding site [chemical binding]; other site
1117647004641	Walker B motif; other site
1117647004642	arginine finger; other site
1117647004643	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1117647004644	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1117647004645	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1117647004646	trimer interface [polypeptide binding]; other site
1117647004647	active site
1117647004648	substrate binding site [chemical binding]; other site
1117647004649	CoA binding site [chemical binding]; other site
1117647004650	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1117647004651	trimer interface [polypeptide binding]; other site
1117647004652	active site
1117647004653	substrate binding site [chemical binding]; other site
1117647004654	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1117647004655	CoA binding site [chemical binding]; other site
1117647004656	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1117647004657	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
1117647004658	acyl-activating enzyme (AAE) consensus motif; other site
1117647004659	active site
1117647004660	AMP binding site [chemical binding]; other site
1117647004661	CoA binding site [chemical binding]; other site
1117647004662	colanic acid exporter; Provisional; Region: PRK10459
1117647004663	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
1117647004664	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1117647004665	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1117647004666	trimer interface [polypeptide binding]; other site
1117647004667	active site
1117647004668	substrate binding site [chemical binding]; other site
1117647004669	CoA binding site [chemical binding]; other site
1117647004670	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
1117647004671	active site
1117647004672	catalytic triad [active]
1117647004673	oxyanion hole [active]
1117647004674	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1117647004675	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
1117647004676	putative active site [active]
1117647004677	putative metal binding site [ion binding]; other site
1117647004678	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1117647004679	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1117647004680	putative active site [active]
1117647004681	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
1117647004682	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
1117647004683	Protein of unknown function (DUF3485); Region: DUF3485; cl11827
1117647004684	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1117647004685	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1117647004686	putative ADP-binding pocket [chemical binding]; other site
1117647004687	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
1117647004688	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1117647004689	DXD motif; other site
1117647004690	rooty/superroot1; Region: PLN02187
1117647004691	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
1117647004692	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1117647004693	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
1117647004694	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647004695	TPR motif; other site
1117647004696	binding surface
1117647004697	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647004698	binding surface
1117647004699	TPR motif; other site
1117647004700	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647004701	binding surface
1117647004702	TPR motif; other site
1117647004703	uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016
1117647004704	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1117647004705	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
1117647004706	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
1117647004707	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1117647004708	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
1117647004709	SLBB domain; Region: SLBB; pfam10531
1117647004710	sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013
1117647004711	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1117647004712	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
1117647004713	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1117647004714	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1117647004715	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1117647004716	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
1117647004717	putative NAD(P) binding site [chemical binding]; other site
1117647004718	active site
1117647004719	putative substrate binding site [chemical binding]; other site
1117647004720	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
1117647004721	polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006
1117647004722	putative active site [active]
1117647004723	putative catalytic site [active]
1117647004724	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1117647004725	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1117647004726	Substrate binding site; other site
1117647004727	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
1117647004728	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
1117647004729	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
1117647004730	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117647004731	Coenzyme A binding pocket [chemical binding]; other site
1117647004732	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
1117647004733	active site
1117647004734	cosubstrate binding site; other site
1117647004735	substrate binding site [chemical binding]; other site
1117647004736	catalytic site [active]
1117647004737	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1117647004738	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1117647004739	dimer interface [polypeptide binding]; other site
1117647004740	ssDNA binding site [nucleotide binding]; other site
1117647004741	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1117647004742	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
1117647004743	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1117647004744	DNA binding residues [nucleotide binding]
1117647004745	dimerization interface [polypeptide binding]; other site
1117647004746	Curli assembly protein CsgE; Region: CsgE; cl08115
1117647004747	Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082
1117647004748	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
1117647004749	Curlin associated repeat; Region: Curlin_rpt; pfam07012
1117647004750	major curlin subunit; Provisional; Region: csgA; PRK10051
1117647004751	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
1117647004752	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
1117647004753	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647004754	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1117647004755	N-terminal plug; other site
1117647004756	ligand-binding site [chemical binding]; other site
1117647004757	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1117647004758	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1117647004759	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1117647004760	alphaNTD homodimer interface [polypeptide binding]; other site
1117647004761	alphaNTD - beta interaction site [polypeptide binding]; other site
1117647004762	alphaNTD - beta' interaction site [polypeptide binding]; other site
1117647004763	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1117647004764	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1117647004765	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1117647004766	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1117647004767	RNA binding surface [nucleotide binding]; other site
1117647004768	30S ribosomal protein S11; Validated; Region: PRK05309
1117647004769	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1117647004770	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1117647004771	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
1117647004772	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1117647004773	SecY translocase; Region: SecY; pfam00344
1117647004774	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1117647004775	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1117647004776	23S rRNA binding site [nucleotide binding]; other site
1117647004777	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1117647004778	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1117647004779	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1117647004780	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1117647004781	5S rRNA interface [nucleotide binding]; other site
1117647004782	23S rRNA interface [nucleotide binding]; other site
1117647004783	L5 interface [polypeptide binding]; other site
1117647004784	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1117647004785	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1117647004786	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1117647004787	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1117647004788	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1117647004789	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1117647004790	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1117647004791	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1117647004792	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1117647004793	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1117647004794	RNA binding site [nucleotide binding]; other site
1117647004795	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1117647004796	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1117647004797	23S rRNA interface [nucleotide binding]; other site
1117647004798	putative translocon interaction site; other site
1117647004799	signal recognition particle (SRP54) interaction site; other site
1117647004800	L23 interface [polypeptide binding]; other site
1117647004801	trigger factor interaction site; other site
1117647004802	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1117647004803	23S rRNA interface [nucleotide binding]; other site
1117647004804	5S rRNA interface [nucleotide binding]; other site
1117647004805	putative antibiotic binding site [chemical binding]; other site
1117647004806	L25 interface [polypeptide binding]; other site
1117647004807	L27 interface [polypeptide binding]; other site
1117647004808	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1117647004809	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1117647004810	G-X-X-G motif; other site
1117647004811	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1117647004812	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1117647004813	protein-rRNA interface [nucleotide binding]; other site
1117647004814	putative translocon binding site; other site
1117647004815	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1117647004816	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1117647004817	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1117647004818	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1117647004819	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1117647004820	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1117647004821	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1117647004822	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1117647004823	elongation factor Tu; Reviewed; Region: PRK00049
1117647004824	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1117647004825	G1 box; other site
1117647004826	GEF interaction site [polypeptide binding]; other site
1117647004827	GTP/Mg2+ binding site [chemical binding]; other site
1117647004828	Switch I region; other site
1117647004829	G2 box; other site
1117647004830	G3 box; other site
1117647004831	Switch II region; other site
1117647004832	G4 box; other site
1117647004833	G5 box; other site
1117647004834	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1117647004835	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1117647004836	Antibiotic Binding Site [chemical binding]; other site
1117647004837	elongation factor G; Reviewed; Region: PRK00007
1117647004838	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1117647004839	G1 box; other site
1117647004840	putative GEF interaction site [polypeptide binding]; other site
1117647004841	GTP/Mg2+ binding site [chemical binding]; other site
1117647004842	Switch I region; other site
1117647004843	G2 box; other site
1117647004844	G3 box; other site
1117647004845	Switch II region; other site
1117647004846	G4 box; other site
1117647004847	G5 box; other site
1117647004848	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1117647004849	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1117647004850	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1117647004851	30S ribosomal protein S7; Validated; Region: PRK05302
1117647004852	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1117647004853	S17 interaction site [polypeptide binding]; other site
1117647004854	S8 interaction site; other site
1117647004855	16S rRNA interaction site [nucleotide binding]; other site
1117647004856	streptomycin interaction site [chemical binding]; other site
1117647004857	23S rRNA interaction site [nucleotide binding]; other site
1117647004858	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1117647004859	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
1117647004860	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1117647004861	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1117647004862	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1117647004863	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1117647004864	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1117647004865	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1117647004866	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1117647004867	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1117647004868	DNA binding site [nucleotide binding]
1117647004869	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1117647004870	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1117647004871	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1117647004872	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1117647004873	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1117647004874	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
1117647004875	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1117647004876	RPB3 interaction site [polypeptide binding]; other site
1117647004877	RPB1 interaction site [polypeptide binding]; other site
1117647004878	RPB11 interaction site [polypeptide binding]; other site
1117647004879	RPB10 interaction site [polypeptide binding]; other site
1117647004880	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1117647004881	core dimer interface [polypeptide binding]; other site
1117647004882	peripheral dimer interface [polypeptide binding]; other site
1117647004883	L10 interface [polypeptide binding]; other site
1117647004884	L11 interface [polypeptide binding]; other site
1117647004885	putative EF-Tu interaction site [polypeptide binding]; other site
1117647004886	putative EF-G interaction site [polypeptide binding]; other site
1117647004887	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1117647004888	23S rRNA interface [nucleotide binding]; other site
1117647004889	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1117647004890	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1117647004891	mRNA/rRNA interface [nucleotide binding]; other site
1117647004892	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1117647004893	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1117647004894	23S rRNA interface [nucleotide binding]; other site
1117647004895	L7/L12 interface [polypeptide binding]; other site
1117647004896	putative thiostrepton binding site; other site
1117647004897	L25 interface [polypeptide binding]; other site
1117647004898	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1117647004899	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1117647004900	putative homodimer interface [polypeptide binding]; other site
1117647004901	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1117647004902	heterodimer interface [polypeptide binding]; other site
1117647004903	homodimer interface [polypeptide binding]; other site
1117647004904	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
1117647004905	elongation factor Tu; Reviewed; Region: PRK00049
1117647004906	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1117647004907	G1 box; other site
1117647004908	GEF interaction site [polypeptide binding]; other site
1117647004909	GTP/Mg2+ binding site [chemical binding]; other site
1117647004910	Switch I region; other site
1117647004911	G2 box; other site
1117647004912	G3 box; other site
1117647004913	Switch II region; other site
1117647004914	G4 box; other site
1117647004915	G5 box; other site
1117647004916	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1117647004917	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1117647004918	Antibiotic Binding Site [chemical binding]; other site
1117647004919	Type III pantothenate kinase; Region: Pan_kinase; cl17198
1117647004920	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
1117647004921	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1117647004922	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1117647004923	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1117647004924	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1117647004925	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1117647004926	active site
1117647004927	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1117647004928	dimer interface [polypeptide binding]; other site
1117647004929	substrate binding site [chemical binding]; other site
1117647004930	catalytic residues [active]
1117647004931	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1117647004932	Permease; Region: Permease; pfam02405
1117647004933	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1117647004934	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1117647004935	Walker A/P-loop; other site
1117647004936	ATP binding site [chemical binding]; other site
1117647004937	Q-loop/lid; other site
1117647004938	ABC transporter signature motif; other site
1117647004939	Walker B; other site
1117647004940	D-loop; other site
1117647004941	H-loop/switch region; other site
1117647004942	mce related protein; Region: MCE; pfam02470
1117647004943	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
1117647004944	Protein of unknown function (DUF330); Region: DUF330; pfam03886
1117647004945	MASE1; Region: MASE1; cl17823
1117647004946	CHASE domain; Region: CHASE; pfam03924
1117647004947	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117647004948	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647004949	dimer interface [polypeptide binding]; other site
1117647004950	phosphorylation site [posttranslational modification]
1117647004951	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647004952	ATP binding site [chemical binding]; other site
1117647004953	Mg2+ binding site [ion binding]; other site
1117647004954	G-X-G motif; other site
1117647004955	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1117647004956	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647004957	active site
1117647004958	phosphorylation site [posttranslational modification]
1117647004959	intermolecular recognition site; other site
1117647004960	dimerization interface [polypeptide binding]; other site
1117647004961	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1117647004962	EamA-like transporter family; Region: EamA; pfam00892
1117647004963	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647004964	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1117647004965	N-terminal plug; other site
1117647004966	ligand-binding site [chemical binding]; other site
1117647004967	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1117647004968	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1117647004969	Protein of unknown function (DUF2167); Region: DUF2167; pfam09935
1117647004970	GTP-binding protein YchF; Reviewed; Region: PRK09601
1117647004971	YchF GTPase; Region: YchF; cd01900
1117647004972	G1 box; other site
1117647004973	GTP/Mg2+ binding site [chemical binding]; other site
1117647004974	Switch I region; other site
1117647004975	G2 box; other site
1117647004976	Switch II region; other site
1117647004977	G3 box; other site
1117647004978	G4 box; other site
1117647004979	G5 box; other site
1117647004980	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1117647004981	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1117647004982	putative active site [active]
1117647004983	catalytic residue [active]
1117647004984	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1117647004985	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1117647004986	5S rRNA interface [nucleotide binding]; other site
1117647004987	CTC domain interface [polypeptide binding]; other site
1117647004988	L16 interface [polypeptide binding]; other site
1117647004989	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1117647004990	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1117647004991	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1117647004992	active site
1117647004993	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
1117647004994	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1117647004995	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1117647004996	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
1117647004997	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
1117647004998	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647004999	TPR motif; other site
1117647005000	binding surface
1117647005001	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647005002	TPR motif; other site
1117647005003	binding surface
1117647005004	TPR repeat; Region: TPR_11; pfam13414
1117647005005	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647005006	binding surface
1117647005007	TPR motif; other site
1117647005008	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1117647005009	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1117647005010	tRNA; other site
1117647005011	putative tRNA binding site [nucleotide binding]; other site
1117647005012	putative NADP binding site [chemical binding]; other site
1117647005013	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1117647005014	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1117647005015	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1117647005016	RF-1 domain; Region: RF-1; pfam00472
1117647005017	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
1117647005018	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647005019	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
1117647005020	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1117647005021	ATP binding site [chemical binding]; other site
1117647005022	substrate interface [chemical binding]; other site
1117647005023	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
1117647005024	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1117647005025	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
1117647005026	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
1117647005027	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1117647005028	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
1117647005029	DsbD alpha interface [polypeptide binding]; other site
1117647005030	catalytic residues [active]
1117647005031	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
1117647005032	putative catalytic residue [active]
1117647005033	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1117647005034	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1117647005035	active site
1117647005036	HIGH motif; other site
1117647005037	dimer interface [polypeptide binding]; other site
1117647005038	KMSKS motif; other site
1117647005039	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
1117647005040	Peptidase family M23; Region: Peptidase_M23; pfam01551
1117647005041	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
1117647005042	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1117647005043	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
1117647005044	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1117647005045	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1117647005046	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1117647005047	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1117647005048	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1117647005049	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1117647005050	Cl- selectivity filter; other site
1117647005051	Cl- binding residues [ion binding]; other site
1117647005052	pore gating glutamate residue; other site
1117647005053	dimer interface [polypeptide binding]; other site
1117647005054	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1117647005055	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1117647005056	active site
1117647005057	catalytic tetrad [active]
1117647005058	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
1117647005059	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1117647005060	substrate binding site [chemical binding]; other site
1117647005061	ATP binding site [chemical binding]; other site
1117647005062	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1117647005063	thiamine phosphate binding site [chemical binding]; other site
1117647005064	active site
1117647005065	pyrophosphate binding site [ion binding]; other site
1117647005066	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1117647005067	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1117647005068	inhibitor-cofactor binding pocket; inhibition site
1117647005069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647005070	catalytic residue [active]
1117647005071	CAAX protease self-immunity; Region: Abi; pfam02517
1117647005072	PilZ domain; Region: PilZ; pfam07238
1117647005073	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
1117647005074	Transglycosylase; Region: Transgly; pfam00912
1117647005075	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1117647005076	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
1117647005077	substrate binding site [chemical binding]; other site
1117647005078	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1117647005079	ATP binding site [chemical binding]; other site
1117647005080	PAS domain; Region: PAS; smart00091
1117647005081	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1117647005082	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647005083	metal binding site [ion binding]; metal-binding site
1117647005084	active site
1117647005085	I-site; other site
1117647005086	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1117647005087	DNA polymerase II; Reviewed; Region: PRK05762
1117647005088	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
1117647005089	active site
1117647005090	catalytic site [active]
1117647005091	substrate binding site [chemical binding]; other site
1117647005092	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
1117647005093	active site
1117647005094	metal-binding site
1117647005095	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095
1117647005096	Protein of unknown function (DUF461); Region: DUF461; pfam04314
1117647005097	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1117647005098	dimerization interface [polypeptide binding]; other site
1117647005099	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647005100	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647005101	metal binding site [ion binding]; metal-binding site
1117647005102	active site
1117647005103	I-site; other site
1117647005104	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1117647005105	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647005106	TPR motif; other site
1117647005107	TPR repeat; Region: TPR_11; pfam13414
1117647005108	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
1117647005109	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
1117647005110	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
1117647005111	DsbD alpha interface [polypeptide binding]; other site
1117647005112	catalytic residues [active]
1117647005113	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1117647005114	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1117647005115	trimer interface [polypeptide binding]; other site
1117647005116	active site
1117647005117	dimer interface [polypeptide binding]; other site
1117647005118	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1117647005119	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1117647005120	carboxyltransferase (CT) interaction site; other site
1117647005121	biotinylation site [posttranslational modification]; other site
1117647005122	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1117647005123	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1117647005124	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1117647005125	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1117647005126	leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411
1117647005127	Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599
1117647005128	active site
1117647005129	Zn binding site [ion binding]; other site
1117647005130	Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127
1117647005131	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1117647005132	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
1117647005133	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
1117647005134	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
1117647005135	putative active site; other site
1117647005136	catalytic triad [active]
1117647005137	putative dimer interface [polypeptide binding]; other site
1117647005138	agmatine deiminase; Provisional; Region: PRK13551
1117647005139	agmatine deiminase; Region: agmatine_aguA; TIGR03380
1117647005140	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1117647005141	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1117647005142	dimer interface [polypeptide binding]; other site
1117647005143	putative CheW interface [polypeptide binding]; other site
1117647005144	Protein of unknown function (DUF3718); Region: DUF3718; pfam12514
1117647005145	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1117647005146	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1117647005147	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1117647005148	putative hydrophobic ligand binding site [chemical binding]; other site
1117647005149	protein interface [polypeptide binding]; other site
1117647005150	gate; other site
1117647005151	hemolysin; Provisional; Region: PRK15087
1117647005152	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1117647005153	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1117647005154	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1117647005155	active site
1117647005156	Zn binding site [ion binding]; other site
1117647005157	CAAX protease self-immunity; Region: Abi; cl00558
1117647005158	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
1117647005159	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1117647005160	active site
1117647005161	catalytic site [active]
1117647005162	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1117647005163	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
1117647005164	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1117647005165	active site
1117647005166	catalytic site [active]
1117647005167	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1117647005168	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647005169	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
1117647005170	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
1117647005171	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647005172	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647005173	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
1117647005174	carbohydrate binding site [chemical binding]; other site
1117647005175	alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103
1117647005176	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1117647005177	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
1117647005178	Ca binding site [ion binding]; other site
1117647005179	active site
1117647005180	catalytic site [active]
1117647005181	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
1117647005182	Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861
1117647005183	Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861
1117647005184	Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861
1117647005185	Flagellar protein YcgR; Region: YcgR_2; pfam12945
1117647005186	PilZ domain; Region: PilZ; pfam07238
1117647005187	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1117647005188	nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482
1117647005189	active site
1117647005190	(T/H)XGH motif; other site
1117647005191	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
1117647005192	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1117647005193	Peptidase family M23; Region: Peptidase_M23; pfam01551
1117647005194	Penicillinase repressor; Region: Pencillinase_R; cl17580
1117647005195	Pirin; Region: Pirin; pfam02678
1117647005196	Pirin-related protein [General function prediction only]; Region: COG1741
1117647005197	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1117647005198	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117647005199	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1117647005200	DNA binding residues [nucleotide binding]
1117647005201	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1117647005202	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1117647005203	Amidohydrolase; Region: Amidohydro_4; pfam13147
1117647005204	active site
1117647005205	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1117647005206	Superinfection immunity protein; Region: Imm_superinfect; pfam14373
1117647005207	thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840
1117647005208	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
1117647005209	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1117647005210	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1117647005211	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1117647005212	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1117647005213	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
1117647005214	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117647005215	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1117647005216	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1117647005217	DNA binding residues [nucleotide binding]
1117647005218	DNA primase, catalytic core; Region: dnaG; TIGR01391
1117647005219	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1117647005220	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1117647005221	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1117647005222	active site
1117647005223	metal binding site [ion binding]; metal-binding site
1117647005224	interdomain interaction site; other site
1117647005225	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1117647005226	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
1117647005227	Yqey-like protein; Region: YqeY; pfam09424
1117647005228	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1117647005229	UGMP family protein; Validated; Region: PRK09604
1117647005230	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1117647005231	Dihydroneopterin aldolase; Region: FolB; smart00905
1117647005232	active site
1117647005233	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1117647005234	catalytic center binding site [active]
1117647005235	ATP binding site [chemical binding]; other site
1117647005236	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
1117647005237	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1117647005238	active site
1117647005239	NTP binding site [chemical binding]; other site
1117647005240	metal binding triad [ion binding]; metal-binding site
1117647005241	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1117647005242	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1117647005243	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1117647005244	active site
1117647005245	PilZ domain; Region: PilZ; pfam07238
1117647005246	flagellar motor protein MotB; Reviewed; Region: motB; PRK08944
1117647005247	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1117647005248	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1117647005249	ligand binding site [chemical binding]; other site
1117647005250	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1117647005251	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1117647005252	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1117647005253	substrate binding pocket [chemical binding]; other site
1117647005254	chain length determination region; other site
1117647005255	substrate-Mg2+ binding site; other site
1117647005256	catalytic residues [active]
1117647005257	aspartate-rich region 1; other site
1117647005258	active site lid residues [active]
1117647005259	aspartate-rich region 2; other site
1117647005260	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1117647005261	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1117647005262	TPP-binding site; other site
1117647005263	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1117647005264	PYR/PP interface [polypeptide binding]; other site
1117647005265	dimer interface [polypeptide binding]; other site
1117647005266	TPP binding site [chemical binding]; other site
1117647005267	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1117647005268	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1117647005269	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1117647005270	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647005271	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647005272	active site
1117647005273	phosphorylation site [posttranslational modification]
1117647005274	intermolecular recognition site; other site
1117647005275	dimerization interface [polypeptide binding]; other site
1117647005276	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1117647005277	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647005278	active site
1117647005279	phosphorylation site [posttranslational modification]
1117647005280	dimerization interface [polypeptide binding]; other site
1117647005281	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647005282	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647005283	metal binding site [ion binding]; metal-binding site
1117647005284	active site
1117647005285	I-site; other site
1117647005286	CHASE domain; Region: CHASE; pfam03924
1117647005287	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1117647005288	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1117647005289	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647005290	dimer interface [polypeptide binding]; other site
1117647005291	phosphorylation site [posttranslational modification]
1117647005292	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647005293	ATP binding site [chemical binding]; other site
1117647005294	Mg2+ binding site [ion binding]; other site
1117647005295	G-X-G motif; other site
1117647005296	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1117647005297	tetramer interfaces [polypeptide binding]; other site
1117647005298	binuclear metal-binding site [ion binding]; other site
1117647005299	thiamine monophosphate kinase; Provisional; Region: PRK05731
1117647005300	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1117647005301	ATP binding site [chemical binding]; other site
1117647005302	dimerization interface [polypeptide binding]; other site
1117647005303	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1117647005304	putative RNA binding site [nucleotide binding]; other site
1117647005305	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1117647005306	homopentamer interface [polypeptide binding]; other site
1117647005307	active site
1117647005308	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
1117647005309	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1117647005310	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
1117647005311	dimerization interface [polypeptide binding]; other site
1117647005312	active site
1117647005313	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1117647005314	Lumazine binding domain; Region: Lum_binding; pfam00677
1117647005315	Lumazine binding domain; Region: Lum_binding; pfam00677
1117647005316	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
1117647005317	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1117647005318	catalytic motif [active]
1117647005319	Zn binding site [ion binding]; other site
1117647005320	RibD C-terminal domain; Region: RibD_C; cl17279
1117647005321	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1117647005322	ATP cone domain; Region: ATP-cone; pfam03477
1117647005323	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1117647005324	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1117647005325	acyl-activating enzyme (AAE) consensus motif; other site
1117647005326	AMP binding site [chemical binding]; other site
1117647005327	active site
1117647005328	CoA binding site [chemical binding]; other site
1117647005329	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1117647005330	putative active site [active]
1117647005331	putative metal binding site [ion binding]; other site
1117647005332	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1117647005333	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1117647005334	ATP-grasp domain; Region: ATP-grasp; pfam02222
1117647005335	EVE domain; Region: EVE; cl00728
1117647005336	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1117647005337	putative binding surface; other site
1117647005338	active site
1117647005339	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647005340	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647005341	active site
1117647005342	phosphorylation site [posttranslational modification]
1117647005343	intermolecular recognition site; other site
1117647005344	dimerization interface [polypeptide binding]; other site
1117647005345	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1117647005346	Protein of unknown function (DUF3094); Region: DUF3094; pfam11293
1117647005347	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1117647005348	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1117647005349	active site
1117647005350	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1117647005351	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1117647005352	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1117647005353	active site
1117647005354	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1117647005355	SprA-related family; Region: SprA-related; pfam12118
1117647005356	AAA domain; Region: AAA_26; pfam13500
1117647005357	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1117647005358	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1117647005359	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1117647005360	active site
1117647005361	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1117647005362	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647005363	S-adenosylmethionine binding site [chemical binding]; other site
1117647005364	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
1117647005365	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1117647005366	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1117647005367	substrate-cofactor binding pocket; other site
1117647005368	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647005369	catalytic residue [active]
1117647005370	biotin synthase; Provisional; Region: PRK15108
1117647005371	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1117647005372	FeS/SAM binding site; other site
1117647005373	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1117647005374	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1117647005375	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1117647005376	active site
1117647005377	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
1117647005378	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1117647005379	dimer interface [polypeptide binding]; other site
1117647005380	active site
1117647005381	CoA binding pocket [chemical binding]; other site
1117647005382	serine/threonine protein kinase; Provisional; Region: PRK11768
1117647005383	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1117647005384	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1117647005385	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117647005386	Coenzyme A binding pocket [chemical binding]; other site
1117647005387	serine acetyltransferase; Provisional; Region: cysE; PRK11132
1117647005388	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
1117647005389	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1117647005390	trimer interface [polypeptide binding]; other site
1117647005391	active site
1117647005392	substrate binding site [chemical binding]; other site
1117647005393	CoA binding site [chemical binding]; other site
1117647005394	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1117647005395	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647005396	putative active site [active]
1117647005397	heme pocket [chemical binding]; other site
1117647005398	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647005399	metal binding site [ion binding]; metal-binding site
1117647005400	active site
1117647005401	I-site; other site
1117647005402	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1117647005403	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1117647005404	dimer interface [polypeptide binding]; other site
1117647005405	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1117647005406	putative CheW interface [polypeptide binding]; other site
1117647005407	Protein of unknown function (DUF935); Region: DUF935; pfam06074
1117647005408	phosphoserine phosphatase SerB; Region: serB; TIGR00338
1117647005409	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117647005410	motif II; other site
1117647005411	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1117647005412	putative catalytic site [active]
1117647005413	putative metal binding site [ion binding]; other site
1117647005414	putative phosphate binding site [ion binding]; other site
1117647005415	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
1117647005416	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
1117647005417	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1117647005418	DNA binding residues [nucleotide binding]
1117647005419	putative dimer interface [polypeptide binding]; other site
1117647005420	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
1117647005421	isovaleryl-CoA dehydrogenase; Region: PLN02519
1117647005422	substrate binding site [chemical binding]; other site
1117647005423	FAD binding site [chemical binding]; other site
1117647005424	catalytic base [active]
1117647005425	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
1117647005426	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1117647005427	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1117647005428	enoyl-CoA hydratase; Provisional; Region: PRK05995
1117647005429	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1117647005430	substrate binding site [chemical binding]; other site
1117647005431	oxyanion hole (OAH) forming residues; other site
1117647005432	trimer interface [polypeptide binding]; other site
1117647005433	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1117647005434	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1117647005435	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1117647005436	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1117647005437	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1117647005438	carboxyltransferase (CT) interaction site; other site
1117647005439	biotinylation site [posttranslational modification]; other site
1117647005440	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1117647005441	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1117647005442	active site
1117647005443	catalytic residues [active]
1117647005444	metal binding site [ion binding]; metal-binding site
1117647005445	Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586
1117647005446	YceI-like domain; Region: YceI; pfam04264
1117647005447	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1117647005448	Interdomain contacts; other site
1117647005449	Cytokine receptor motif; other site
1117647005450	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1117647005451	Protein of unknown function (DUF1595); Region: PSD5; pfam07637
1117647005452	Protein of unknown function (DUF1592); Region: PSD4; pfam07631
1117647005453	Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627
1117647005454	YceI-like domain; Region: YceI; pfam04264
1117647005455	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1117647005456	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1117647005457	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1117647005458	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1117647005459	SapC; Region: SapC; pfam07277
1117647005460	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
1117647005461	Smr domain; Region: Smr; pfam01713
1117647005462	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1117647005463	active site
1117647005464	acetyl-CoA synthetase; Provisional; Region: PRK00174
1117647005465	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1117647005466	active site
1117647005467	CoA binding site [chemical binding]; other site
1117647005468	acyl-activating enzyme (AAE) consensus motif; other site
1117647005469	AMP binding site [chemical binding]; other site
1117647005470	acetate binding site [chemical binding]; other site
1117647005471	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1117647005472	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1117647005473	active site
1117647005474	ATP binding site [chemical binding]; other site
1117647005475	substrate binding site [chemical binding]; other site
1117647005476	activation loop (A-loop); other site
1117647005477	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647005478	TPR motif; other site
1117647005479	binding surface
1117647005480	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647005481	TPR motif; other site
1117647005482	binding surface
1117647005483	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1117647005484	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1117647005485	PhoH-like protein; Region: PhoH; pfam02562
1117647005486	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1117647005487	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647005488	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647005489	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647005490	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1117647005491	putative active site [active]
1117647005492	heme pocket [chemical binding]; other site
1117647005493	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647005494	dimer interface [polypeptide binding]; other site
1117647005495	phosphorylation site [posttranslational modification]
1117647005496	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647005497	ATP binding site [chemical binding]; other site
1117647005498	G-X-G motif; other site
1117647005499	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647005500	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647005501	active site
1117647005502	phosphorylation site [posttranslational modification]
1117647005503	intermolecular recognition site; other site
1117647005504	dimerization interface [polypeptide binding]; other site
1117647005505	CAAX protease self-immunity; Region: Abi; pfam02517
1117647005506	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1117647005507	tetramerization interface [polypeptide binding]; other site
1117647005508	active site
1117647005509	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1117647005510	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1117647005511	active site
1117647005512	ATP-binding site [chemical binding]; other site
1117647005513	pantoate-binding site; other site
1117647005514	HXXH motif; other site
1117647005515	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
1117647005516	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
1117647005517	replicative DNA helicase; Region: DnaB; TIGR00665
1117647005518	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1117647005519	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1117647005520	Walker A motif; other site
1117647005521	ATP binding site [chemical binding]; other site
1117647005522	Walker B motif; other site
1117647005523	DNA binding loops [nucleotide binding]
1117647005524	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1117647005525	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1117647005526	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1117647005527	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1117647005528	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
1117647005529	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1117647005530	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1117647005531	exoribonuclease R; Provisional; Region: PRK11642
1117647005532	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1117647005533	RNB domain; Region: RNB; pfam00773
1117647005534	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1117647005535	RNA binding site [nucleotide binding]; other site
1117647005536	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647005537	PAS domain; Region: PAS_9; pfam13426
1117647005538	putative active site [active]
1117647005539	heme pocket [chemical binding]; other site
1117647005540	PAS domain; Region: PAS; smart00091
1117647005541	PAS domain; Region: PAS_9; pfam13426
1117647005542	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647005543	putative active site [active]
1117647005544	heme pocket [chemical binding]; other site
1117647005545	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647005546	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647005547	metal binding site [ion binding]; metal-binding site
1117647005548	active site
1117647005549	I-site; other site
1117647005550	Predicted membrane protein [Function unknown]; Region: COG3235
1117647005551	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
1117647005552	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647005553	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647005554	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
1117647005555	Pectic acid lyase; Region: Pec_lyase; pfam09492
1117647005556	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1117647005557	Amb_all domain; Region: Amb_all; smart00656
1117647005558	Amb_all domain; Region: Amb_all; smart00656
1117647005559	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
1117647005560	Ca binding site [ion binding]; other site
1117647005561	Ca binding site (active) [ion binding]; other site
1117647005562	ligand binding site [chemical binding]; other site
1117647005563	Pectate lyase; Region: Pec_lyase_C; cl01593
1117647005564	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1117647005565	DNA-binding site [nucleotide binding]; DNA binding site
1117647005566	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
1117647005567	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1117647005568	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1117647005569	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1117647005570	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1117647005571	glucuronate isomerase; Reviewed; Region: PRK02925
1117647005572	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
1117647005573	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1117647005574	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1117647005575	substrate binding site [chemical binding]; other site
1117647005576	ATP binding site [chemical binding]; other site
1117647005577	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
1117647005578	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
1117647005579	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1117647005580	NADP binding site [chemical binding]; other site
1117647005581	homodimer interface [polypeptide binding]; other site
1117647005582	active site
1117647005583	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
1117647005584	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
1117647005585	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647005586	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1117647005587	ligand-binding site [chemical binding]; other site
1117647005588	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
1117647005589	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1117647005590	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1117647005591	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1117647005592	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1117647005593	putative pectinesterase; Region: PLN02432; cl01911
1117647005594	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1117647005595	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1117647005596	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1117647005597	DctM-like transporters; Region: DctM; pfam06808
1117647005598	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1117647005599	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1117647005600	active site
1117647005601	catalytic triad [active]
1117647005602	YHYH protein; Region: YHYH; pfam14240
1117647005603	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
1117647005604	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1117647005605	Cu(I) binding site [ion binding]; other site
1117647005606	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
1117647005607	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647005608	active site
1117647005609	phosphorylation site [posttranslational modification]
1117647005610	intermolecular recognition site; other site
1117647005611	dimerization interface [polypeptide binding]; other site
1117647005612	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1117647005613	DNA binding site [nucleotide binding]
1117647005614	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
1117647005615	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647005616	dimer interface [polypeptide binding]; other site
1117647005617	phosphorylation site [posttranslational modification]
1117647005618	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647005619	ATP binding site [chemical binding]; other site
1117647005620	Mg2+ binding site [ion binding]; other site
1117647005621	G-X-G motif; other site
1117647005622	Alginate lyase; Region: Alginate_lyase2; pfam08787
1117647005623	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1117647005624	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1117647005625	Alginate lyase; Region: Alginate_lyase2; pfam08787
1117647005626	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1117647005627	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1117647005628	DNA-binding site [nucleotide binding]; DNA binding site
1117647005629	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1117647005630	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1117647005631	classical (c) SDRs; Region: SDR_c; cd05233
1117647005632	NAD(P) binding site [chemical binding]; other site
1117647005633	active site
1117647005634	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647005635	D-galactonate transporter; Region: 2A0114; TIGR00893
1117647005636	putative substrate translocation pore; other site
1117647005637	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647005638	Right handed beta helix region; Region: Beta_helix; pfam13229
1117647005639	Protein of unknown function (DUF808); Region: DUF808; pfam05661
1117647005640	von Willebrand factor; Region: vWF_A; pfam12450
1117647005641	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
1117647005642	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
1117647005643	metal ion-dependent adhesion site (MIDAS); other site
1117647005644	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
1117647005645	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1117647005646	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117647005647	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1117647005648	DNA binding residues [nucleotide binding]
1117647005649	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1117647005650	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1117647005651	active site
1117647005652	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
1117647005653	putative dimer interface [polypeptide binding]; other site
1117647005654	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1117647005655	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
1117647005656	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1117647005657	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1117647005658	catalytic core [active]
1117647005659	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1117647005660	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1117647005661	putative dimer interface [polypeptide binding]; other site
1117647005662	active site pocket [active]
1117647005663	putative cataytic base [active]
1117647005664	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1117647005665	homotrimer interface [polypeptide binding]; other site
1117647005666	Walker A motif; other site
1117647005667	GTP binding site [chemical binding]; other site
1117647005668	Walker B motif; other site
1117647005669	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
1117647005670	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
1117647005671	RimK-like ATP-grasp domain; Region: RimK; pfam08443
1117647005672	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
1117647005673	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
1117647005674	putative active site [active]
1117647005675	Zn binding site [ion binding]; other site
1117647005676	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1117647005677	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
1117647005678	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
1117647005679	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647005680	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647005681	metal binding site [ion binding]; metal-binding site
1117647005682	active site
1117647005683	I-site; other site
1117647005684	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1117647005685	MgtE intracellular N domain; Region: MgtE_N; pfam03448
1117647005686	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1117647005687	Divalent cation transporter; Region: MgtE; pfam01769
1117647005688	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1117647005689	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117647005690	Walker A/P-loop; other site
1117647005691	ATP binding site [chemical binding]; other site
1117647005692	Q-loop/lid; other site
1117647005693	ABC transporter signature motif; other site
1117647005694	Walker B; other site
1117647005695	D-loop; other site
1117647005696	H-loop/switch region; other site
1117647005697	ABC transporter; Region: ABC_tran_2; pfam12848
1117647005698	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1117647005699	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647005700	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647005701	metal binding site [ion binding]; metal-binding site
1117647005702	active site
1117647005703	I-site; other site
1117647005704	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1117647005705	Putative zinc-finger; Region: zf-HC2; pfam13490
1117647005706	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
1117647005707	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117647005708	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1117647005709	DNA binding residues [nucleotide binding]
1117647005710	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1117647005711	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1117647005712	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1117647005713	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1117647005714	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1117647005715	tetrameric interface [polypeptide binding]; other site
1117647005716	NAD binding site [chemical binding]; other site
1117647005717	catalytic residues [active]
1117647005718	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1117647005719	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
1117647005720	substrate binding pocket [chemical binding]; other site
1117647005721	FAD binding site [chemical binding]; other site
1117647005722	catalytic base [active]
1117647005723	enoyl-CoA hydratase; Provisional; Region: PRK09076
1117647005724	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1117647005725	substrate binding site [chemical binding]; other site
1117647005726	oxyanion hole (OAH) forming residues; other site
1117647005727	trimer interface [polypeptide binding]; other site
1117647005728	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
1117647005729	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1117647005730	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1117647005731	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117647005732	Coenzyme A binding pocket [chemical binding]; other site
1117647005733	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1117647005734	GAF domain; Region: GAF; pfam01590
1117647005735	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1117647005736	GAF domain; Region: GAF_3; pfam13492
1117647005737	GAF domain; Region: GAF_2; pfam13185
1117647005738	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1117647005739	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647005740	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647005741	metal binding site [ion binding]; metal-binding site
1117647005742	active site
1117647005743	I-site; other site
1117647005744	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1117647005745	PAS domain; Region: PAS; smart00091
1117647005746	PAS fold; Region: PAS_4; pfam08448
1117647005747	PAS fold; Region: PAS_4; pfam08448
1117647005748	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647005749	putative active site [active]
1117647005750	heme pocket [chemical binding]; other site
1117647005751	PAS fold; Region: PAS_3; pfam08447
1117647005752	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
1117647005753	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647005754	PAS domain; Region: PAS_9; pfam13426
1117647005755	putative active site [active]
1117647005756	heme pocket [chemical binding]; other site
1117647005757	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647005758	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647005759	metal binding site [ion binding]; metal-binding site
1117647005760	active site
1117647005761	I-site; other site
1117647005762	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1117647005763	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
1117647005764	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
1117647005765	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
1117647005766	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
1117647005767	proposed catalytic triad [active]
1117647005768	active site nucleophile [active]
1117647005769	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1117647005770	conserved cys residue [active]
1117647005771	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1117647005772	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1117647005773	isoaspartyl dipeptidase; Provisional; Region: PRK10657
1117647005774	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1117647005775	active site
1117647005776	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
1117647005777	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1117647005778	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647005779	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647005780	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647005781	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1117647005782	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1117647005783	tetramer interface [polypeptide binding]; other site
1117647005784	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1117647005785	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
1117647005786	proposed catalytic triad [active]
1117647005787	active site nucleophile [active]
1117647005788	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1117647005789	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1117647005790	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1117647005791	dimer interface [polypeptide binding]; other site
1117647005792	active site
1117647005793	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1117647005794	folate binding site [chemical binding]; other site
1117647005795	Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313
1117647005796	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1117647005797	active site
1117647005798	catalytic site [active]
1117647005799	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
1117647005800	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647005801	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647005802	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
1117647005803	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
1117647005804	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1117647005805	CtsZ (cyclic tetrasaccharide-synthesizing enzyme Z) is a bacterial 6-alpha-glucosyltransferase, first identified in Arthrobacter globiformis, that produces cyclic tetrasaccharides together with a closely related enzyme CtsY.  CtsZ and CtsY both have a...; Region: GH31_transferase_CtsZ; cd06598
1117647005806	putative active site [active]
1117647005807	putative catalytic site [active]
1117647005808	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1117647005809	Putative esterase; Region: Esterase; pfam00756
1117647005810	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1117647005811	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1117647005812	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1117647005813	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1117647005814	putative DNA binding site [nucleotide binding]; other site
1117647005815	putative Zn2+ binding site [ion binding]; other site
1117647005816	AsnC family; Region: AsnC_trans_reg; pfam01037
1117647005817	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
1117647005818	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1117647005819	homodimer interface [polypeptide binding]; other site
1117647005820	substrate-cofactor binding pocket; other site
1117647005821	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647005822	catalytic residue [active]
1117647005823	hypothetical protein; Provisional; Region: PRK08262
1117647005824	M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674
1117647005825	metal binding site [ion binding]; metal-binding site
1117647005826	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
1117647005827	DNA repair protein RadA; Provisional; Region: PRK11823
1117647005828	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1117647005829	Walker A motif; other site
1117647005830	ATP binding site [chemical binding]; other site
1117647005831	Walker B motif; other site
1117647005832	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1117647005833	The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor...; Region: Link_Domain; cl02612
1117647005834	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
1117647005835	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1117647005836	DNA-binding site [nucleotide binding]; DNA binding site
1117647005837	RNA-binding motif; other site
1117647005838	Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973
1117647005839	putative active site [active]
1117647005840	putative metal binding site [ion binding]; other site
1117647005841	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
1117647005842	Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; pfam06315
1117647005843	PilZ domain; Region: PilZ; pfam07238
1117647005844	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1117647005845	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1117647005846	CAP-like domain; other site
1117647005847	active site
1117647005848	primary dimer interface [polypeptide binding]; other site
1117647005849	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1117647005850	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
1117647005851	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1117647005852	active site
1117647005853	FMN binding site [chemical binding]; other site
1117647005854	substrate binding site [chemical binding]; other site
1117647005855	3Fe-4S cluster binding site [ion binding]; other site
1117647005856	acetolactate synthase; Reviewed; Region: PRK08322
1117647005857	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1117647005858	PYR/PP interface [polypeptide binding]; other site
1117647005859	dimer interface [polypeptide binding]; other site
1117647005860	TPP binding site [chemical binding]; other site
1117647005861	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1117647005862	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1117647005863	TPP-binding site [chemical binding]; other site
1117647005864	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1117647005865	Na binding site [ion binding]; other site
1117647005866	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1117647005867	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1117647005868	HlyD family secretion protein; Region: HlyD_3; pfam13437
1117647005869	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1117647005870	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1117647005871	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
1117647005872	Late embryogenesis abundant protein; Region: LEA_2; cl12118
1117647005873	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
1117647005874	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
1117647005875	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
1117647005876	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1117647005877	pyruvate kinase; Provisional; Region: PRK05826
1117647005878	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1117647005879	domain interfaces; other site
1117647005880	active site
1117647005881	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117647005882	Coenzyme A binding pocket [chemical binding]; other site
1117647005883	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1117647005884	AAA domain; Region: AAA_23; pfam13476
1117647005885	Protein of unknown function (DUF3732); Region: DUF3732; pfam12532
1117647005886	Restriction endonuclease; Region: Mrr_cat; pfam04471
1117647005887	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
1117647005888	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1117647005889	putative ligand binding site [chemical binding]; other site
1117647005890	putative NAD binding site [chemical binding]; other site
1117647005891	catalytic site [active]
1117647005892	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1117647005893	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1117647005894	Cation efflux family; Region: Cation_efflux; cl00316
1117647005895	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
1117647005896	CHAP domain; Region: CHAP; pfam05257
1117647005897	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
1117647005898	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
1117647005899	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
1117647005900	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1117647005901	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
1117647005902	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1117647005903	active site residue [active]
1117647005904	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1117647005905	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
1117647005906	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117647005907	Walker A/P-loop; other site
1117647005908	ATP binding site [chemical binding]; other site
1117647005909	Q-loop/lid; other site
1117647005910	ABC transporter signature motif; other site
1117647005911	Walker B; other site
1117647005912	D-loop; other site
1117647005913	H-loop/switch region; other site
1117647005914	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1117647005915	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
1117647005916	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
1117647005917	selenophosphate synthetase; Provisional; Region: PRK00943
1117647005918	dimerization interface [polypeptide binding]; other site
1117647005919	putative ATP binding site [chemical binding]; other site
1117647005920	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1117647005921	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
1117647005922	Protein of unknown function DUF45; Region: DUF45; pfam01863
1117647005923	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1117647005924	CoenzymeA binding site [chemical binding]; other site
1117647005925	subunit interaction site [polypeptide binding]; other site
1117647005926	PHB binding site; other site
1117647005927	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1117647005928	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
1117647005929	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1117647005930	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647005931	Mg2+ binding site [ion binding]; other site
1117647005932	G-X-G motif; other site
1117647005933	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1117647005934	anchoring element; other site
1117647005935	dimer interface [polypeptide binding]; other site
1117647005936	ATP binding site [chemical binding]; other site
1117647005937	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1117647005938	active site
1117647005939	metal binding site [ion binding]; metal-binding site
1117647005940	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1117647005941	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
1117647005942	dimerization interface [polypeptide binding]; other site
1117647005943	substrate binding site [chemical binding]; other site
1117647005944	active site
1117647005945	calcium binding site [ion binding]; other site
1117647005946	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
1117647005947	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1117647005948	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1117647005949	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1117647005950	active site
1117647005951	metal binding site [ion binding]; metal-binding site
1117647005952	hexamer interface [polypeptide binding]; other site
1117647005953	Protein of unknown function (DUF1249); Region: DUF1249; pfam06853
1117647005954	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
1117647005955	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1117647005956	dimer interface [polypeptide binding]; other site
1117647005957	ADP-ribose binding site [chemical binding]; other site
1117647005958	active site
1117647005959	nudix motif; other site
1117647005960	metal binding site [ion binding]; metal-binding site
1117647005961	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
1117647005962	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1117647005963	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1117647005964	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1117647005965	ThiC-associated domain; Region: ThiC-associated; pfam13667
1117647005966	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
1117647005967	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1117647005968	dimer interface [polypeptide binding]; other site
1117647005969	substrate binding site [chemical binding]; other site
1117647005970	ATP binding site [chemical binding]; other site
1117647005971	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
1117647005972	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647005973	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647005974	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647005975	choline dehydrogenase; Validated; Region: PRK02106
1117647005976	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1117647005977	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1117647005978	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1117647005979	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1117647005980	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
1117647005981	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
1117647005982	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
1117647005983	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1117647005984	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1117647005985	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1117647005986	active site
1117647005987	catalytic tetrad [active]
1117647005988	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1117647005989	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1117647005990	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
1117647005991	putative active site [active]
1117647005992	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1117647005993	Zn binding site [ion binding]; other site
1117647005994	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
1117647005995	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647005996	Walker A motif; other site
1117647005997	ATP binding site [chemical binding]; other site
1117647005998	Walker B motif; other site
1117647005999	arginine finger; other site
1117647006000	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1117647006001	CheW-like domain; Region: CheW; pfam01584
1117647006002	CheB methylesterase; Region: CheB_methylest; pfam01339
1117647006003	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1117647006004	putative binding surface; other site
1117647006005	active site
1117647006006	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1117647006007	putative binding surface; other site
1117647006008	active site
1117647006009	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1117647006010	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1117647006011	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647006012	ATP binding site [chemical binding]; other site
1117647006013	Mg2+ binding site [ion binding]; other site
1117647006014	G-X-G motif; other site
1117647006015	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1117647006016	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647006017	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647006018	active site
1117647006019	phosphorylation site [posttranslational modification]
1117647006020	intermolecular recognition site; other site
1117647006021	dimerization interface [polypeptide binding]; other site
1117647006022	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1117647006023	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
1117647006024	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1117647006025	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
1117647006026	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1117647006027	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1117647006028	dimer interface [polypeptide binding]; other site
1117647006029	putative CheW interface [polypeptide binding]; other site
1117647006030	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1117647006031	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647006032	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647006033	active site
1117647006034	phosphorylation site [posttranslational modification]
1117647006035	intermolecular recognition site; other site
1117647006036	dimerization interface [polypeptide binding]; other site
1117647006037	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647006038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647006039	active site
1117647006040	phosphorylation site [posttranslational modification]
1117647006041	intermolecular recognition site; other site
1117647006042	dimerization interface [polypeptide binding]; other site
1117647006043	glutathione synthetase; Provisional; Region: PRK05246
1117647006044	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
1117647006045	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
1117647006046	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1117647006047	hypothetical protein; Validated; Region: PRK00228
1117647006048	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1117647006049	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
1117647006050	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1117647006051	Walker A motif; other site
1117647006052	ATP binding site [chemical binding]; other site
1117647006053	Walker B motif; other site
1117647006054	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1117647006055	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1117647006056	YGGT family; Region: YGGT; pfam02325
1117647006057	YGGT family; Region: YGGT; pfam02325
1117647006058	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
1117647006059	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1117647006060	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1117647006061	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1117647006062	Dynamin family; Region: Dynamin_N; pfam00350
1117647006063	G1 box; other site
1117647006064	GTP/Mg2+ binding site [chemical binding]; other site
1117647006065	G2 box; other site
1117647006066	Switch I region; other site
1117647006067	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1117647006068	G3 box; other site
1117647006069	Switch II region; other site
1117647006070	GTP/Mg2+ binding site [chemical binding]; other site
1117647006071	G4 box; other site
1117647006072	G5 box; other site
1117647006073	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
1117647006074	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
1117647006075	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1117647006076	Domain of unknown function (DUF4426); Region: DUF4426; pfam14467
1117647006077	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1117647006078	active site
1117647006079	dimerization interface [polypeptide binding]; other site
1117647006080	HemN family oxidoreductase; Provisional; Region: PRK05660
1117647006081	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1117647006082	FeS/SAM binding site; other site
1117647006083	HemN C-terminal domain; Region: HemN_C; pfam06969
1117647006084	HAMP domain; Region: HAMP; pfam00672
1117647006085	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647006086	dimer interface [polypeptide binding]; other site
1117647006087	phosphorylation site [posttranslational modification]
1117647006088	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647006089	ATP binding site [chemical binding]; other site
1117647006090	Mg2+ binding site [ion binding]; other site
1117647006091	G-X-G motif; other site
1117647006092	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1117647006093	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647006094	active site
1117647006095	phosphorylation site [posttranslational modification]
1117647006096	intermolecular recognition site; other site
1117647006097	dimerization interface [polypeptide binding]; other site
1117647006098	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647006099	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647006100	active site
1117647006101	phosphorylation site [posttranslational modification]
1117647006102	intermolecular recognition site; other site
1117647006103	dimerization interface [polypeptide binding]; other site
1117647006104	Isochorismatase family; Region: Isochorismatase; pfam00857
1117647006105	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1117647006106	catalytic triad [active]
1117647006107	conserved cis-peptide bond; other site
1117647006108	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1117647006109	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1117647006110	mercuric reductase; Validated; Region: PRK06370
1117647006111	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1117647006112	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1117647006113	polyphosphate kinase; Provisional; Region: PRK05443
1117647006114	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1117647006115	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1117647006116	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1117647006117	putative domain interface [polypeptide binding]; other site
1117647006118	putative active site [active]
1117647006119	catalytic site [active]
1117647006120	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1117647006121	putative domain interface [polypeptide binding]; other site
1117647006122	putative active site [active]
1117647006123	catalytic site [active]
1117647006124	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1117647006125	catalytic residues [active]
1117647006126	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1117647006127	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1117647006128	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1117647006129	RNA binding site [nucleotide binding]; other site
1117647006130	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1117647006131	multimer interface [polypeptide binding]; other site
1117647006132	Walker A motif; other site
1117647006133	ATP binding site [chemical binding]; other site
1117647006134	Walker B motif; other site
1117647006135	mechanosensitive channel MscS; Provisional; Region: PRK10334
1117647006136	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1117647006137	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
1117647006138	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1117647006139	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
1117647006140	active site
1117647006141	nucleophile elbow; other site
1117647006142	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
1117647006143	Surface antigen; Region: Bac_surface_Ag; pfam01103
1117647006144	Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474
1117647006145	Na binding site [ion binding]; other site
1117647006146	putative glycosylation site [posttranslational modification]; other site
1117647006147	putative glycosylation site [posttranslational modification]; other site
1117647006148	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1117647006149	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1117647006150	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
1117647006151	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1117647006152	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1117647006153	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1117647006154	Protein of unknown function (DUF4013); Region: DUF4013; pfam13197
1117647006155	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
1117647006156	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
1117647006157	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
1117647006158	NAD(P) binding site [chemical binding]; other site
1117647006159	catalytic residues [active]
1117647006160	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1117647006161	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
1117647006162	ligand binding site [chemical binding]; other site
1117647006163	homodimer interface [polypeptide binding]; other site
1117647006164	NAD(P) binding site [chemical binding]; other site
1117647006165	trimer interface B [polypeptide binding]; other site
1117647006166	trimer interface A [polypeptide binding]; other site
1117647006167	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1117647006168	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
1117647006169	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1117647006170	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
1117647006171	ATPase involved in DNA repair; Region: DUF3686; pfam12458
1117647006172	AAA domain; Region: AAA_22; pfam13401
1117647006173	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647006174	Walker A motif; other site
1117647006175	ATP binding site [chemical binding]; other site
1117647006176	Walker B motif; other site
1117647006177	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
1117647006178	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
1117647006179	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1117647006180	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938
1117647006181	HDOD domain; Region: HDOD; pfam08668
1117647006182	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
1117647006183	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
1117647006184	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1117647006185	metal binding site [ion binding]; metal-binding site
1117647006186	putative dimer interface [polypeptide binding]; other site
1117647006187	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1117647006188	catalytic residues [active]
1117647006189	short chain dehydrogenase; Provisional; Region: PRK08251
1117647006190	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117647006191	NAD(P) binding site [chemical binding]; other site
1117647006192	active site
1117647006193	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1117647006194	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1117647006195	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
1117647006196	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
1117647006197	ligand binding site [chemical binding]; other site
1117647006198	NAD binding site [chemical binding]; other site
1117647006199	tetramer interface [polypeptide binding]; other site
1117647006200	catalytic site [active]
1117647006201	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
1117647006202	L-serine binding site [chemical binding]; other site
1117647006203	ACT domain interface; other site
1117647006204	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1117647006205	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1117647006206	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1117647006207	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
1117647006208	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
1117647006209	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
1117647006210	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1117647006211	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1117647006212	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1117647006213	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1117647006214	non-specific DNA binding site [nucleotide binding]; other site
1117647006215	salt bridge; other site
1117647006216	sequence-specific DNA binding site [nucleotide binding]; other site
1117647006217	2TM domain; Region: 2TM; pfam13239
1117647006218	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1117647006219	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1117647006220	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1117647006221	MarR family; Region: MarR_2; pfam12802
1117647006222	MarR family; Region: MarR_2; cl17246
1117647006223	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
1117647006224	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1117647006225	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
1117647006226	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
1117647006227	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1117647006228	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647006229	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647006230	metal binding site [ion binding]; metal-binding site
1117647006231	active site
1117647006232	I-site; other site
1117647006233	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
1117647006234	catalytic residues [active]
1117647006235	hinge region; other site
1117647006236	alpha helical domain; other site
1117647006237	Cytochrome c553 [Energy production and conversion]; Region: COG2863
1117647006238	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1117647006239	Cytochrome c553 [Energy production and conversion]; Region: COG2863
1117647006240	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1117647006241	G1 box; other site
1117647006242	GTP/Mg2+ binding site [chemical binding]; other site
1117647006243	Switch I region; other site
1117647006244	G2 box; other site
1117647006245	G3 box; other site
1117647006246	Switch II region; other site
1117647006247	G4 box; other site
1117647006248	G5 box; other site
1117647006249	Hemin uptake protein hemP; Region: hemP; cl10043
1117647006250	DNA polymerase I; Provisional; Region: PRK05755
1117647006251	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1117647006252	active site
1117647006253	metal binding site 1 [ion binding]; metal-binding site
1117647006254	putative 5' ssDNA interaction site; other site
1117647006255	metal binding site 3; metal-binding site
1117647006256	metal binding site 2 [ion binding]; metal-binding site
1117647006257	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1117647006258	putative DNA binding site [nucleotide binding]; other site
1117647006259	putative metal binding site [ion binding]; other site
1117647006260	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
1117647006261	active site
1117647006262	catalytic site [active]
1117647006263	substrate binding site [chemical binding]; other site
1117647006264	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1117647006265	active site
1117647006266	DNA binding site [nucleotide binding]
1117647006267	catalytic site [active]
1117647006268	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
1117647006269	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
1117647006270	Hemerythrin-like domain; Region: Hr-like; cd12108
1117647006271	Fe binding site [ion binding]; other site
1117647006272	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1117647006273	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117647006274	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
1117647006275	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1117647006276	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1117647006277	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1117647006278	intersubunit interface [polypeptide binding]; other site
1117647006279	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1117647006280	metal binding site 2 [ion binding]; metal-binding site
1117647006281	putative DNA binding helix; other site
1117647006282	metal binding site 1 [ion binding]; metal-binding site
1117647006283	dimer interface [polypeptide binding]; other site
1117647006284	structural Zn2+ binding site [ion binding]; other site
1117647006285	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
1117647006286	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1117647006287	Alpha trans-inducing protein (Alpha-TIF); Region: Alpha_TIF; cl03493
1117647006288	Protein of unknown function (DUF1428); Region: DUF1428; pfam07237
1117647006289	Uncharacterized conserved protein [Function unknown]; Region: COG2968
1117647006290	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1117647006291	Transposase; Region: HTH_Tnp_1; pfam01527
1117647006292	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1117647006293	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
1117647006294	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
1117647006295	Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720
1117647006296	Domain of unknown function (DUF4380); Region: DUF4380; pfam14315
1117647006297	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
1117647006298	HemY protein N-terminus; Region: HemY_N; pfam07219
1117647006299	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
1117647006300	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
1117647006301	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
1117647006302	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1117647006303	active site
1117647006304	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1117647006305	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1117647006306	domain interfaces; other site
1117647006307	active site
1117647006308	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1117647006309	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647006310	active site
1117647006311	phosphorylation site [posttranslational modification]
1117647006312	intermolecular recognition site; other site
1117647006313	dimerization interface [polypeptide binding]; other site
1117647006314	LytTr DNA-binding domain; Region: LytTR; smart00850
1117647006315	Histidine kinase; Region: His_kinase; pfam06580
1117647006316	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1117647006317	ATP binding site [chemical binding]; other site
1117647006318	Mg2+ binding site [ion binding]; other site
1117647006319	G-X-G motif; other site
1117647006320	argininosuccinate lyase; Provisional; Region: PRK00855
1117647006321	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1117647006322	active sites [active]
1117647006323	tetramer interface [polypeptide binding]; other site
1117647006324	GAF domain; Region: GAF; pfam01590
1117647006325	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647006326	PAS fold; Region: PAS_3; pfam08447
1117647006327	putative active site [active]
1117647006328	heme pocket [chemical binding]; other site
1117647006329	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647006330	PAS fold; Region: PAS_3; pfam08447
1117647006331	putative active site [active]
1117647006332	heme pocket [chemical binding]; other site
1117647006333	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117647006334	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647006335	dimer interface [polypeptide binding]; other site
1117647006336	phosphorylation site [posttranslational modification]
1117647006337	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647006338	ATP binding site [chemical binding]; other site
1117647006339	Mg2+ binding site [ion binding]; other site
1117647006340	G-X-G motif; other site
1117647006341	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647006342	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647006343	active site
1117647006344	phosphorylation site [posttranslational modification]
1117647006345	intermolecular recognition site; other site
1117647006346	dimerization interface [polypeptide binding]; other site
1117647006347	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647006348	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647006349	active site
1117647006350	phosphorylation site [posttranslational modification]
1117647006351	intermolecular recognition site; other site
1117647006352	dimerization interface [polypeptide binding]; other site
1117647006353	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1117647006354	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1117647006355	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647006356	PAS fold; Region: PAS_3; pfam08447
1117647006357	putative active site [active]
1117647006358	heme pocket [chemical binding]; other site
1117647006359	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117647006360	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647006361	dimer interface [polypeptide binding]; other site
1117647006362	phosphorylation site [posttranslational modification]
1117647006363	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647006364	ATP binding site [chemical binding]; other site
1117647006365	Mg2+ binding site [ion binding]; other site
1117647006366	G-X-G motif; other site
1117647006367	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647006368	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647006369	active site
1117647006370	phosphorylation site [posttranslational modification]
1117647006371	intermolecular recognition site; other site
1117647006372	dimerization interface [polypeptide binding]; other site
1117647006373	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1117647006374	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647006375	active site
1117647006376	phosphorylation site [posttranslational modification]
1117647006377	intermolecular recognition site; other site
1117647006378	dimerization interface [polypeptide binding]; other site
1117647006379	adenylate cyclase; Provisional; Region: cyaA; PRK09450
1117647006380	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
1117647006381	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
1117647006382	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
1117647006383	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1117647006384	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1117647006385	active site
1117647006386	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1117647006387	substrate binding site [chemical binding]; other site
1117647006388	catalytic residues [active]
1117647006389	dimer interface [polypeptide binding]; other site
1117647006390	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1117647006391	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1117647006392	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1117647006393	Protein of unknown function, DUF484; Region: DUF484; cl17449
1117647006394	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1117647006395	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1117647006396	active site
1117647006397	DNA binding site [nucleotide binding]
1117647006398	Int/Topo IB signature motif; other site
1117647006399	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1117647006400	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117647006401	motif II; other site
1117647006402	Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547
1117647006403	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
1117647006404	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1117647006405	Enoylreductase; Region: PKS_ER; smart00829
1117647006406	NAD(P) binding site [chemical binding]; other site
1117647006407	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
1117647006408	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1117647006409	putative active site [active]
1117647006410	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
1117647006411	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1117647006412	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
1117647006413	Domain of unknown function (DUF4392); Region: DUF4392; pfam14336
1117647006414	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1117647006415	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1117647006416	DNA binding residues [nucleotide binding]
1117647006417	dimerization interface [polypeptide binding]; other site
1117647006418	Sodium Bile acid symporter family; Region: SBF; cl17470
1117647006419	hypothetical protein; Provisional; Region: PRK06208
1117647006420	intersubunit interface [polypeptide binding]; other site
1117647006421	active site
1117647006422	Zn2+ binding site [ion binding]; other site
1117647006423	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1117647006424	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117647006425	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1117647006426	substrate binding pocket [chemical binding]; other site
1117647006427	dimerization interface [polypeptide binding]; other site
1117647006428	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647006429	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647006430	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647006431	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1117647006432	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1117647006433	active site
1117647006434	dimer interface [polypeptide binding]; other site
1117647006435	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1117647006436	dimer interface [polypeptide binding]; other site
1117647006437	active site
1117647006438	DTW domain; Region: DTW; cl01221
1117647006439	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
1117647006440	DNA binding site [nucleotide binding]
1117647006441	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1117647006442	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1117647006443	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1117647006444	PhnA protein; Region: PhnA; pfam03831
1117647006445	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1117647006446	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1117647006447	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1117647006448	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1117647006449	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647006450	binding surface
1117647006451	TPR motif; other site
1117647006452	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1117647006453	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647006454	binding surface
1117647006455	TPR motif; other site
1117647006456	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1117647006457	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1117647006458	ApbE family; Region: ApbE; pfam02424
1117647006459	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
1117647006460	Type II secretion system (T2SS), protein M; Region: T2SM; cl01222
1117647006461	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
1117647006462	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
1117647006463	GspL periplasmic domain; Region: GspL_C; cl14909
1117647006464	type II secretion system protein J; Region: gspJ; TIGR01711
1117647006465	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
1117647006466	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
1117647006467	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1117647006468	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
1117647006469	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
1117647006470	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
1117647006471	type II secretion system protein E; Region: type_II_gspE; TIGR02533
1117647006472	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1117647006473	Walker A motif; other site
1117647006474	ATP binding site [chemical binding]; other site
1117647006475	Walker B motif; other site
1117647006476	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
1117647006477	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
1117647006478	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1117647006479	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1117647006480	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
1117647006481	Bacterial SH3 domain; Region: SH3_3; pfam08239
1117647006482	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1117647006483	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1117647006484	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1117647006485	catalytic residues [active]
1117647006486	Domain of unknown function (DUF4266); Region: DUF4266; pfam14086
1117647006487	Protein of unknown function (DUF3570); Region: DUF3570; pfam12094
1117647006488	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1117647006489	hypothetical protein; Provisional; Region: PRK05415
1117647006490	Domain of unknown function (DUF697); Region: DUF697; pfam05128
1117647006491	YcjX-like family, DUF463; Region: DUF463; cl01193
1117647006492	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1117647006493	dimerization interface [polypeptide binding]; other site
1117647006494	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647006495	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647006496	metal binding site [ion binding]; metal-binding site
1117647006497	active site
1117647006498	I-site; other site
1117647006499	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1117647006500	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1117647006501	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1117647006502	Cu(I) binding site [ion binding]; other site
1117647006503	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1117647006504	UbiA prenyltransferase family; Region: UbiA; pfam01040
1117647006505	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
1117647006506	Subunit III/VIIa interface [polypeptide binding]; other site
1117647006507	Phospholipid binding site [chemical binding]; other site
1117647006508	Subunit I/III interface [polypeptide binding]; other site
1117647006509	Subunit III/VIb interface [polypeptide binding]; other site
1117647006510	Subunit III/VIa interface; other site
1117647006511	Subunit III/Vb interface [polypeptide binding]; other site
1117647006512	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
1117647006513	cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007
1117647006514	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
1117647006515	Subunit I/III interface [polypeptide binding]; other site
1117647006516	D-pathway; other site
1117647006517	Subunit I/VIIc interface [polypeptide binding]; other site
1117647006518	Subunit I/IV interface [polypeptide binding]; other site
1117647006519	Subunit I/II interface [polypeptide binding]; other site
1117647006520	Low-spin heme (heme a) binding site [chemical binding]; other site
1117647006521	Subunit I/VIIa interface [polypeptide binding]; other site
1117647006522	Subunit I/VIa interface [polypeptide binding]; other site
1117647006523	Dimer interface; other site
1117647006524	Putative water exit pathway; other site
1117647006525	Binuclear center (heme a3/CuB) [ion binding]; other site
1117647006526	K-pathway; other site
1117647006527	Subunit I/Vb interface [polypeptide binding]; other site
1117647006528	Putative proton exit pathway; other site
1117647006529	Subunit I/VIb interface; other site
1117647006530	Subunit I/VIc interface [polypeptide binding]; other site
1117647006531	Electron transfer pathway; other site
1117647006532	Subunit I/VIIIb interface [polypeptide binding]; other site
1117647006533	Subunit I/VIIb interface [polypeptide binding]; other site
1117647006534	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1117647006535	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
1117647006536	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
1117647006537	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1117647006538	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1117647006539	active site
1117647006540	Zn binding site [ion binding]; other site
1117647006541	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1117647006542	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1117647006543	trimer interface [polypeptide binding]; other site
1117647006544	putative metal binding site [ion binding]; other site
1117647006545	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1117647006546	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1117647006547	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1117647006548	shikimate binding site; other site
1117647006549	NAD(P) binding site [chemical binding]; other site
1117647006550	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
1117647006551	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
1117647006552	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1117647006553	DNA protecting protein DprA; Region: dprA; TIGR00732
1117647006554	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1117647006555	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1117647006556	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
1117647006557	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1117647006558	active site
1117647006559	catalytic residues [active]
1117647006560	metal binding site [ion binding]; metal-binding site
1117647006561	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1117647006562	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1117647006563	putative active site [active]
1117647006564	substrate binding site [chemical binding]; other site
1117647006565	putative cosubstrate binding site; other site
1117647006566	catalytic site [active]
1117647006567	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1117647006568	substrate binding site [chemical binding]; other site
1117647006569	Cation transport protein; Region: TrkH; cl17365
1117647006570	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1117647006571	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1117647006572	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1117647006573	putative acyl-acceptor binding pocket; other site
1117647006574	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1117647006575	dimer interface [polypeptide binding]; other site
1117647006576	motif 1; other site
1117647006577	active site
1117647006578	motif 2; other site
1117647006579	motif 3; other site
1117647006580	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1117647006581	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
1117647006582	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117647006583	active site
1117647006584	motif I; other site
1117647006585	motif II; other site
1117647006586	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1117647006587	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1117647006588	putative acyl-acceptor binding pocket; other site
1117647006589	recombination protein F; Reviewed; Region: recF; PRK00064
1117647006590	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117647006591	Walker A/P-loop; other site
1117647006592	ATP binding site [chemical binding]; other site
1117647006593	Q-loop/lid; other site
1117647006594	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117647006595	ABC transporter signature motif; other site
1117647006596	DNA polymerase III subunit beta; Validated; Region: PRK05643
1117647006597	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1117647006598	putative DNA binding surface [nucleotide binding]; other site
1117647006599	dimer interface [polypeptide binding]; other site
1117647006600	beta-clamp/clamp loader binding surface; other site
1117647006601	beta-clamp/translesion DNA polymerase binding surface; other site
1117647006602	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1117647006603	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
1117647006604	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647006605	Walker A motif; other site
1117647006606	ATP binding site [chemical binding]; other site
1117647006607	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1117647006608	Walker B motif; other site
1117647006609	arginine finger; other site
1117647006610	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1117647006611	DnaA box-binding interface [nucleotide binding]; other site
1117647006612	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1117647006613	Ribonuclease P; Region: Ribonuclease_P; cl00457
1117647006614	Haemolytic domain; Region: Haemolytic; pfam01809
1117647006615	membrane protein insertase; Provisional; Region: PRK01318
1117647006616	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1117647006617	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1117647006618	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1117647006619	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1117647006620	G1 box; other site
1117647006621	GTP/Mg2+ binding site [chemical binding]; other site
1117647006622	Switch I region; other site
1117647006623	G2 box; other site
1117647006624	Switch II region; other site
1117647006625	G3 box; other site
1117647006626	G4 box; other site
1117647006627	G5 box; other site
1117647006628	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1117647006629	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1117647006630	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1117647006631	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
1117647006632	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1117647006633	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
1117647006634	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
1117647006635	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1117647006636	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1117647006637	P-loop; other site
1117647006638	Magnesium ion binding site [ion binding]; other site
1117647006639	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1117647006640	ParB-like nuclease domain; Region: ParBc; pfam02195
1117647006641	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1117647006642	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1117647006643	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1117647006644	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1117647006645	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1117647006646	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1117647006647	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1117647006648	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1117647006649	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1117647006650	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1117647006651	beta subunit interaction interface [polypeptide binding]; other site
1117647006652	Walker A motif; other site
1117647006653	ATP binding site [chemical binding]; other site
1117647006654	Walker B motif; other site
1117647006655	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1117647006656	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1117647006657	core domain interface [polypeptide binding]; other site
1117647006658	delta subunit interface [polypeptide binding]; other site
1117647006659	epsilon subunit interface [polypeptide binding]; other site
1117647006660	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1117647006661	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1117647006662	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1117647006663	alpha subunit interaction interface [polypeptide binding]; other site
1117647006664	Walker A motif; other site
1117647006665	ATP binding site [chemical binding]; other site
1117647006666	Walker B motif; other site
1117647006667	inhibitor binding site; inhibition site
1117647006668	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1117647006669	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1117647006670	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1117647006671	gamma subunit interface [polypeptide binding]; other site
1117647006672	epsilon subunit interface [polypeptide binding]; other site
1117647006673	LBP interface [polypeptide binding]; other site
1117647006674	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
1117647006675	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1117647006676	Substrate binding site; other site
1117647006677	Mg++ binding site; other site
1117647006678	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1117647006679	active site
1117647006680	substrate binding site [chemical binding]; other site
1117647006681	CoA binding site [chemical binding]; other site
1117647006682	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1117647006683	RNA binding surface [nucleotide binding]; other site
1117647006684	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1117647006685	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
1117647006686	Part of AAA domain; Region: AAA_19; pfam13245
1117647006687	Family description; Region: UvrD_C_2; pfam13538
1117647006688	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1117647006689	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
1117647006690	DctM-like transporters; Region: DctM; pfam06808
1117647006691	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
1117647006692	PBP superfamily domain; Region: PBP_like_2; pfam12849
1117647006693	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
1117647006694	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1117647006695	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117647006696	dimer interface [polypeptide binding]; other site
1117647006697	conserved gate region; other site
1117647006698	putative PBP binding loops; other site
1117647006699	ABC-ATPase subunit interface; other site
1117647006700	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
1117647006701	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1117647006702	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117647006703	dimer interface [polypeptide binding]; other site
1117647006704	conserved gate region; other site
1117647006705	putative PBP binding loops; other site
1117647006706	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1117647006707	ABC-ATPase subunit interface; other site
1117647006708	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
1117647006709	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1117647006710	Walker A/P-loop; other site
1117647006711	ATP binding site [chemical binding]; other site
1117647006712	Q-loop/lid; other site
1117647006713	ABC transporter signature motif; other site
1117647006714	Walker B; other site
1117647006715	D-loop; other site
1117647006716	H-loop/switch region; other site
1117647006717	transcriptional regulator PhoU; Provisional; Region: PRK11115
1117647006718	PhoU domain; Region: PhoU; pfam01895
1117647006719	PhoU domain; Region: PhoU; pfam01895
1117647006720	Domain of unknown function (DUF4265); Region: DUF4265; pfam14085
1117647006721	hypothetical protein; Validated; Region: PRK02101
1117647006722	TfoX N-terminal domain; Region: TfoX_N; cl17592
1117647006723	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647006724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647006725	active site
1117647006726	phosphorylation site [posttranslational modification]
1117647006727	intermolecular recognition site; other site
1117647006728	dimerization interface [polypeptide binding]; other site
1117647006729	Protein of unknown function (DUF938); Region: DUF938; pfam06080
1117647006730	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
1117647006731	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1117647006732	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647006733	putative active site [active]
1117647006734	heme pocket [chemical binding]; other site
1117647006735	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647006736	dimer interface [polypeptide binding]; other site
1117647006737	phosphorylation site [posttranslational modification]
1117647006738	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647006739	ATP binding site [chemical binding]; other site
1117647006740	Mg2+ binding site [ion binding]; other site
1117647006741	G-X-G motif; other site
1117647006742	Chorismate lyase; Region: Chor_lyase; cl01230
1117647006743	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1117647006744	IHF dimer interface [polypeptide binding]; other site
1117647006745	IHF - DNA interface [nucleotide binding]; other site
1117647006746	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1117647006747	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1117647006748	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1117647006749	Y-family of DNA polymerases; Region: PolY; cl12025
1117647006750	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1117647006751	generic binding surface II; other site
1117647006752	ssDNA binding site; other site
1117647006753	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117647006754	ATP binding site [chemical binding]; other site
1117647006755	putative Mg++ binding site [ion binding]; other site
1117647006756	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117647006757	nucleotide binding region [chemical binding]; other site
1117647006758	ATP-binding site [chemical binding]; other site
1117647006759	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117647006760	NAD(P) binding site [chemical binding]; other site
1117647006761	active site
1117647006762	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1117647006763	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1117647006764	homotrimer interaction site [polypeptide binding]; other site
1117647006765	putative active site [active]
1117647006766	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
1117647006767	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1117647006768	Zn2+ binding site [ion binding]; other site
1117647006769	Mg2+ binding site [ion binding]; other site
1117647006770	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1117647006771	synthetase active site [active]
1117647006772	NTP binding site [chemical binding]; other site
1117647006773	metal binding site [ion binding]; metal-binding site
1117647006774	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1117647006775	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1117647006776	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1117647006777	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1117647006778	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1117647006779	catalytic site [active]
1117647006780	G-X2-G-X-G-K; other site
1117647006781	hypothetical protein; Provisional; Region: PRK11820
1117647006782	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1117647006783	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1117647006784	ribonuclease PH; Reviewed; Region: rph; PRK00173
1117647006785	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1117647006786	hexamer interface [polypeptide binding]; other site
1117647006787	active site
1117647006788	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
1117647006789	putative active site [active]
1117647006790	putative catalytic site [active]
1117647006791	putative DNA binding site [nucleotide binding]; other site
1117647006792	putative phosphate binding site [ion binding]; other site
1117647006793	metal binding site A [ion binding]; metal-binding site
1117647006794	putative AP binding site [nucleotide binding]; other site
1117647006795	putative metal binding site B [ion binding]; other site
1117647006796	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1117647006797	active site
1117647006798	division inhibitor protein; Provisional; Region: slmA; PRK09480
1117647006799	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117647006800	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1117647006801	feedback inhibition sensing region; other site
1117647006802	homohexameric interface [polypeptide binding]; other site
1117647006803	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
1117647006804	nucleotide binding site [chemical binding]; other site
1117647006805	N-acetyl-L-glutamate binding site [chemical binding]; other site
1117647006806	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1117647006807	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1117647006808	active site
1117647006809	substrate binding site [chemical binding]; other site
1117647006810	metal binding site [ion binding]; metal-binding site
1117647006811	hypothetical protein; Reviewed; Region: PRK00024
1117647006812	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1117647006813	MPN+ (JAMM) motif; other site
1117647006814	Zinc-binding site [ion binding]; other site
1117647006815	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
1117647006816	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1117647006817	putative ADP-binding pocket [chemical binding]; other site
1117647006818	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1117647006819	PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; cl17608
1117647006820	O-Antigen ligase; Region: Wzy_C; pfam04932
1117647006821	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1117647006822	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1117647006823	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1117647006824	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1117647006825	DNA binding site [nucleotide binding]
1117647006826	catalytic residue [active]
1117647006827	H2TH interface [polypeptide binding]; other site
1117647006828	putative catalytic residues [active]
1117647006829	turnover-facilitating residue; other site
1117647006830	intercalation triad [nucleotide binding]; other site
1117647006831	8OG recognition residue [nucleotide binding]; other site
1117647006832	putative reading head residues; other site
1117647006833	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1117647006834	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1117647006835	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1117647006836	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1117647006837	active site
1117647006838	(T/H)XGH motif; other site
1117647006839	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1117647006840	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647006841	S-adenosylmethionine binding site [chemical binding]; other site
1117647006842	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1117647006843	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1117647006844	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1117647006845	GTP binding site [chemical binding]; other site
1117647006846	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1117647006847	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117647006848	Walker A/P-loop; other site
1117647006849	ATP binding site [chemical binding]; other site
1117647006850	Q-loop/lid; other site
1117647006851	ABC transporter signature motif; other site
1117647006852	Walker B; other site
1117647006853	D-loop; other site
1117647006854	H-loop/switch region; other site
1117647006855	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1117647006856	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
1117647006857	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647006858	S-adenosylmethionine binding site [chemical binding]; other site
1117647006859	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
1117647006860	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1117647006861	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1117647006862	ligand binding site [chemical binding]; other site
1117647006863	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
1117647006864	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
1117647006865	active site
1117647006866	catalytic triad [active]
1117647006867	oxyanion hole [active]
1117647006868	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1117647006869	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
1117647006870	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1117647006871	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1117647006872	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1117647006873	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1117647006874	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1117647006875	structural tetrad; other site
1117647006876	Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; pfam04353
1117647006877	LrgB-like family; Region: LrgB; pfam04172
1117647006878	LrgA family; Region: LrgA; pfam03788
1117647006879	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
1117647006880	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
1117647006881	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
1117647006882	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1117647006883	Protein of unknown function, DUF479; Region: DUF479; cl01203
1117647006884	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
1117647006885	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1117647006886	HlyD family secretion protein; Region: HlyD_3; pfam13437
1117647006887	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1117647006888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647006889	active site
1117647006890	phosphorylation site [posttranslational modification]
1117647006891	intermolecular recognition site; other site
1117647006892	dimerization interface [polypeptide binding]; other site
1117647006893	LytTr DNA-binding domain; Region: LytTR; smart00850
1117647006894	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117647006895	Histidine kinase; Region: His_kinase; pfam06580
1117647006896	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647006897	ATP binding site [chemical binding]; other site
1117647006898	Mg2+ binding site [ion binding]; other site
1117647006899	G-X-G motif; other site
1117647006900	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
1117647006901	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1117647006902	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
1117647006903	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
1117647006904	potential frameshift: common BLAST hit: gi|254788263|ref|YP_003075692.1| transposase
1117647006905	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
1117647006906	Part of AAA domain; Region: AAA_19; pfam13245
1117647006907	Family description; Region: UvrD_C_2; pfam13538
1117647006908	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1117647006909	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1117647006910	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1117647006911	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647006912	active site
1117647006913	phosphorylation site [posttranslational modification]
1117647006914	intermolecular recognition site; other site
1117647006915	dimerization interface [polypeptide binding]; other site
1117647006916	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647006917	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647006918	metal binding site [ion binding]; metal-binding site
1117647006919	active site
1117647006920	I-site; other site
1117647006921	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1117647006922	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1117647006923	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1117647006924	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647006925	Walker A motif; other site
1117647006926	ATP binding site [chemical binding]; other site
1117647006927	Walker B motif; other site
1117647006928	arginine finger; other site
1117647006929	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1117647006930	Membrane fusogenic activity; Region: BMFP; pfam04380
1117647006931	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
1117647006932	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1117647006933	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1117647006934	probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644
1117647006935	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1117647006936	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1117647006937	Protein of unknown function (DUF523); Region: DUF523; pfam04463
1117647006938	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1117647006939	HlyD family secretion protein; Region: HlyD_3; pfam13437
1117647006940	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1117647006941	Protein export membrane protein; Region: SecD_SecF; cl14618
1117647006942	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
1117647006943	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647006944	active site
1117647006945	phosphorylation site [posttranslational modification]
1117647006946	intermolecular recognition site; other site
1117647006947	dimerization interface [polypeptide binding]; other site
1117647006948	HD domain; Region: HD_5; pfam13487
1117647006949	Heme NO binding; Region: HNOB; pfam07700
1117647006950	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647006951	ATP binding site [chemical binding]; other site
1117647006952	Mg2+ binding site [ion binding]; other site
1117647006953	G-X-G motif; other site
1117647006954	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1117647006955	substrate binding pocket [chemical binding]; other site
1117647006956	membrane-bound complex binding site; other site
1117647006957	hinge residues; other site
1117647006958	EamA-like transporter family; Region: EamA; cl17759
1117647006959	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1117647006960	active site
1117647006961	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
1117647006962	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1117647006963	dimerization interface [polypeptide binding]; other site
1117647006964	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647006965	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647006966	metal binding site [ion binding]; metal-binding site
1117647006967	active site
1117647006968	I-site; other site
1117647006969	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1117647006970	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1117647006971	motif II; other site
1117647006972	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1117647006973	RNA binding surface [nucleotide binding]; other site
1117647006974	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1117647006975	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1117647006976	active site
1117647006977	substrate-binding site [chemical binding]; other site
1117647006978	metal-binding site [ion binding]
1117647006979	ATP binding site [chemical binding]; other site
1117647006980	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1117647006981	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1117647006982	active site
1117647006983	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1117647006984	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1117647006985	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1117647006986	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647006987	active site
1117647006988	phosphorylation site [posttranslational modification]
1117647006989	intermolecular recognition site; other site
1117647006990	dimerization interface [polypeptide binding]; other site
1117647006991	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647006992	Walker A motif; other site
1117647006993	ATP binding site [chemical binding]; other site
1117647006994	Walker B motif; other site
1117647006995	arginine finger; other site
1117647006996	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1117647006997	Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407
1117647006998	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1117647006999	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1117647007000	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1117647007001	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
1117647007002	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1117647007003	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
1117647007004	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
1117647007005	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1117647007006	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1117647007007	active site
1117647007008	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1117647007009	Protein of unknown function (DUF3080); Region: DUF3080; pfam11279
1117647007010	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
1117647007011	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
1117647007012	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
1117647007013	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1117647007014	Peptidase family C69; Region: Peptidase_C69; cl17793
1117647007015	oxidative damage protection protein; Provisional; Region: PRK05408
1117647007016	adenine DNA glycosylase; Provisional; Region: PRK10880
1117647007017	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1117647007018	minor groove reading motif; other site
1117647007019	helix-hairpin-helix signature motif; other site
1117647007020	substrate binding pocket [chemical binding]; other site
1117647007021	active site
1117647007022	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1117647007023	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1117647007024	DNA binding and oxoG recognition site [nucleotide binding]
1117647007025	AsmA family; Region: AsmA; pfam05170
1117647007026	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1117647007027	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1117647007028	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1117647007029	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1117647007030	lipoyl attachment site [posttranslational modification]; other site
1117647007031	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1117647007032	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1117647007033	dimerization interface [polypeptide binding]; other site
1117647007034	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647007035	metal binding site [ion binding]; metal-binding site
1117647007036	active site
1117647007037	I-site; other site
1117647007038	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1117647007039	Protein of unknown function (DUF3034); Region: DUF3034; pfam11231
1117647007040	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1117647007041	apolar tunnel; other site
1117647007042	heme binding site [chemical binding]; other site
1117647007043	dimerization interface [polypeptide binding]; other site
1117647007044	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117647007045	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1117647007046	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1117647007047	C-terminal domain interface [polypeptide binding]; other site
1117647007048	GSH binding site (G-site) [chemical binding]; other site
1117647007049	dimer interface [polypeptide binding]; other site
1117647007050	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
1117647007051	N-terminal domain interface [polypeptide binding]; other site
1117647007052	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
1117647007053	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
1117647007054	nucleotide binding site [chemical binding]; other site
1117647007055	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1117647007056	SBD interface [polypeptide binding]; other site
1117647007057	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
1117647007058	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1117647007059	HSP70 interaction site [polypeptide binding]; other site
1117647007060	RDD family; Region: RDD; pfam06271
1117647007061	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1117647007062	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1117647007063	THF binding site; other site
1117647007064	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1117647007065	substrate binding site [chemical binding]; other site
1117647007066	THF binding site; other site
1117647007067	zinc-binding site [ion binding]; other site
1117647007068	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
1117647007069	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117647007070	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
1117647007071	putative dimerization interface [polypeptide binding]; other site
1117647007072	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
1117647007073	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1117647007074	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1117647007075	putative RNA binding site [nucleotide binding]; other site
1117647007076	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647007077	S-adenosylmethionine binding site [chemical binding]; other site
1117647007078	Imelysin; Region: Peptidase_M75; cl09159
1117647007079	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
1117647007080	putative active site [active]
1117647007081	Ap4A binding site [chemical binding]; other site
1117647007082	nudix motif; other site
1117647007083	putative metal binding site [ion binding]; other site
1117647007084	NRDE protein; Region: NRDE; cl01315
1117647007085	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1117647007086	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1117647007087	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1117647007088	folate binding site [chemical binding]; other site
1117647007089	NADP+ binding site [chemical binding]; other site
1117647007090	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1117647007091	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
1117647007092	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1117647007093	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1117647007094	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1117647007095	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647007096	binding surface
1117647007097	TPR motif; other site
1117647007098	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1117647007099	Sulfatase; Region: Sulfatase; pfam00884
1117647007100	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647007101	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647007102	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647007103	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1117647007104	N-acetylglutamate synthase; Validated; Region: PRK05279
1117647007105	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
1117647007106	putative feedback inhibition sensing region; other site
1117647007107	putative nucleotide binding site [chemical binding]; other site
1117647007108	putative substrate binding site [chemical binding]; other site
1117647007109	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117647007110	Coenzyme A binding pocket [chemical binding]; other site
1117647007111	acetylornithine deacetylase; Provisional; Region: PRK05111
1117647007112	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
1117647007113	metal binding site [ion binding]; metal-binding site
1117647007114	putative dimer interface [polypeptide binding]; other site
1117647007115	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1117647007116	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1117647007117	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1117647007118	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1117647007119	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1117647007120	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
1117647007121	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1117647007122	Walker A motif; other site
1117647007123	ATP binding site [chemical binding]; other site
1117647007124	Walker B motif; other site
1117647007125	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1117647007126	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1117647007127	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1117647007128	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1117647007129	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1117647007130	NADP binding site [chemical binding]; other site
1117647007131	active site
1117647007132	putative substrate binding site [chemical binding]; other site
1117647007133	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
1117647007134	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1117647007135	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1117647007136	Walker A/P-loop; other site
1117647007137	ATP binding site [chemical binding]; other site
1117647007138	Q-loop/lid; other site
1117647007139	ABC transporter signature motif; other site
1117647007140	Walker B; other site
1117647007141	D-loop; other site
1117647007142	H-loop/switch region; other site
1117647007143	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
1117647007144	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
1117647007145	putative ribose interaction site [chemical binding]; other site
1117647007146	putative ADP binding site [chemical binding]; other site
1117647007147	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
1117647007148	active site
1117647007149	nucleotide binding site [chemical binding]; other site
1117647007150	HIGH motif; other site
1117647007151	KMSKS motif; other site
1117647007152	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1117647007153	RNA methyltransferase, RsmE family; Region: TIGR00046
1117647007154	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1117647007155	FAD binding site [chemical binding]; other site
1117647007156	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1117647007157	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1117647007158	homotetramer interface [polypeptide binding]; other site
1117647007159	ligand binding site [chemical binding]; other site
1117647007160	catalytic site [active]
1117647007161	NAD binding site [chemical binding]; other site
1117647007162	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1117647007163	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1117647007164	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1117647007165	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1117647007166	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1117647007167	dimerization interface [polypeptide binding]; other site
1117647007168	putative DNA binding site [nucleotide binding]; other site
1117647007169	putative Zn2+ binding site [ion binding]; other site
1117647007170	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1117647007171	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647007172	S-adenosylmethionine binding site [chemical binding]; other site
1117647007173	FOG: PKD repeat [General function prediction only]; Region: COG3291
1117647007174	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
1117647007175	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
1117647007176	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1117647007177	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1117647007178	active site
1117647007179	catalytic residues [active]
1117647007180	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1117647007181	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1117647007182	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
1117647007183	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1117647007184	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1117647007185	Penicillinase repressor; Region: Pencillinase_R; cl17580
1117647007186	transketolase; Reviewed; Region: PRK12753
1117647007187	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1117647007188	TPP-binding site [chemical binding]; other site
1117647007189	dimer interface [polypeptide binding]; other site
1117647007190	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1117647007191	PYR/PP interface [polypeptide binding]; other site
1117647007192	dimer interface [polypeptide binding]; other site
1117647007193	TPP binding site [chemical binding]; other site
1117647007194	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1117647007195	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1117647007196	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1117647007197	intersubunit interface [polypeptide binding]; other site
1117647007198	active site
1117647007199	zinc binding site [ion binding]; other site
1117647007200	Na+ binding site [ion binding]; other site
1117647007201	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1117647007202	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1117647007203	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
1117647007204	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1117647007205	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
1117647007206	active site
1117647007207	dimer interface [polypeptide binding]; other site
1117647007208	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1117647007209	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1117647007210	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1117647007211	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
1117647007212	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1117647007213	active site
1117647007214	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1117647007215	Protein of unknown function (DUF2860); Region: DUF2860; pfam11059
1117647007216	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
1117647007217	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1117647007218	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
1117647007219	putative [Fe4-S4] binding site [ion binding]; other site
1117647007220	putative molybdopterin cofactor binding site [chemical binding]; other site
1117647007221	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
1117647007222	putative molybdopterin cofactor binding site; other site
1117647007223	DTW domain; Region: DTW; cl01221
1117647007224	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
1117647007225	AAA ATPase domain; Region: AAA_16; pfam13191
1117647007226	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1117647007227	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1117647007228	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1117647007229	MOSC domain; Region: MOSC; pfam03473
1117647007230	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1117647007231	integron integrase; Region: integrase_gron; TIGR02249
1117647007232	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
1117647007233	Int/Topo IB signature motif; other site
1117647007234	Domain of unknown function (DU1801); Region: DUF1801; cl17490
1117647007235	Domain of unknown function (DU1801); Region: DUF1801; cl17490
1117647007236	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
1117647007237	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
1117647007238	Predicted permeases [General function prediction only]; Region: COG0679
1117647007239	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
1117647007240	MAPEG family; Region: MAPEG; cl09190
1117647007241	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1117647007242	active site
1117647007243	metal binding site [ion binding]; metal-binding site
1117647007244	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1117647007245	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
1117647007246	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1117647007247	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1117647007248	active site
1117647007249	nucleophile elbow; other site
1117647007250	TfoX N-terminal domain; Region: TfoX_N; cl17592
1117647007251	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1117647007252	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
1117647007253	conserved cys residue [active]
1117647007254	Protein of unknown function (DUF454); Region: DUF454; pfam04304
1117647007255	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1117647007256	catalytic residues [active]
1117647007257	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
1117647007258	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1117647007259	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1117647007260	active site
1117647007261	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1117647007262	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
1117647007263	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
1117647007264	Walker A/P-loop; other site
1117647007265	ATP binding site [chemical binding]; other site
1117647007266	Q-loop/lid; other site
1117647007267	ABC transporter signature motif; other site
1117647007268	Walker B; other site
1117647007269	D-loop; other site
1117647007270	H-loop/switch region; other site
1117647007271	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1117647007272	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1117647007273	active site
1117647007274	dimer interface [polypeptide binding]; other site
1117647007275	threonine dehydratase; Reviewed; Region: PRK09224
1117647007276	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1117647007277	tetramer interface [polypeptide binding]; other site
1117647007278	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647007279	catalytic residue [active]
1117647007280	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
1117647007281	putative Ile/Val binding site [chemical binding]; other site
1117647007282	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1117647007283	putative Ile/Val binding site [chemical binding]; other site
1117647007284	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
1117647007285	Cell division protein ZapA; Region: ZapA; pfam05164
1117647007286	TIGR02449 family protein; Region: TIGR02449
1117647007287	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
1117647007288	proline aminopeptidase P II; Provisional; Region: PRK10879
1117647007289	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
1117647007290	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1117647007291	active site
1117647007292	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1117647007293	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
1117647007294	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
1117647007295	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1117647007296	Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632
1117647007297	dimer interface [polypeptide binding]; other site
1117647007298	putative inhibitory loop; other site
1117647007299	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
1117647007300	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117647007301	Coenzyme A binding pocket [chemical binding]; other site
1117647007302	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1117647007303	non-specific DNA binding site [nucleotide binding]; other site
1117647007304	salt bridge; other site
1117647007305	sequence-specific DNA binding site [nucleotide binding]; other site
1117647007306	OsmC-like protein; Region: OsmC; pfam02566
1117647007307	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
1117647007308	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1117647007309	putative metal binding site [ion binding]; other site
1117647007310	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1117647007311	putative trimer interface [polypeptide binding]; other site
1117647007312	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1117647007313	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1117647007314	trimer interface [polypeptide binding]; other site
1117647007315	active site
1117647007316	substrate binding site [chemical binding]; other site
1117647007317	putative CoA binding site [chemical binding]; other site
1117647007318	CoA binding site [chemical binding]; other site
1117647007319	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1117647007320	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1117647007321	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1117647007322	Methyltransferase domain; Region: Methyltransf_24; pfam13578
1117647007323	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
1117647007324	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
1117647007325	Flavivirus non-structural Protein NS1; Region: Flavi_NS1; pfam00948
1117647007326	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647007327	S-adenosylmethionine binding site [chemical binding]; other site
1117647007328	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1117647007329	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1117647007330	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647007331	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1117647007332	N-terminal plug; other site
1117647007333	ligand-binding site [chemical binding]; other site
1117647007334	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1117647007335	anti sigma factor interaction site; other site
1117647007336	regulatory phosphorylation site [posttranslational modification]; other site
1117647007337	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1117647007338	putative active site pocket [active]
1117647007339	4-fold oligomerization interface [polypeptide binding]; other site
1117647007340	metal binding residues [ion binding]; metal-binding site
1117647007341	3-fold/trimer interface [polypeptide binding]; other site
1117647007342	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
1117647007343	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1117647007344	putative active site [active]
1117647007345	oxyanion strand; other site
1117647007346	catalytic triad [active]
1117647007347	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1117647007348	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1117647007349	catalytic residues [active]
1117647007350	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1117647007351	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1117647007352	substrate binding site [chemical binding]; other site
1117647007353	glutamase interaction surface [polypeptide binding]; other site
1117647007354	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
1117647007355	NodB motif; other site
1117647007356	putative active site [active]
1117647007357	putative catalytic site [active]
1117647007358	Zn binding site [ion binding]; other site
1117647007359	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1117647007360	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1117647007361	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1117647007362	protein binding site [polypeptide binding]; other site
1117647007363	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1117647007364	Catalytic dyad [active]
1117647007365	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
1117647007366	Adhesion protein FadA; Region: FadA; pfam09403
1117647007367	Peptidase family M23; Region: Peptidase_M23; pfam01551
1117647007368	CHD5-like protein; Region: CHD5; pfam04420
1117647007369	phosphoglyceromutase; Provisional; Region: PRK05434
1117647007370	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1117647007371	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1117647007372	active site residue [active]
1117647007373	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
1117647007374	GSH binding site [chemical binding]; other site
1117647007375	catalytic residues [active]
1117647007376	Preprotein translocase subunit SecB; Region: SecB; pfam02556
1117647007377	SecA binding site; other site
1117647007378	Preprotein binding site; other site
1117647007379	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
1117647007380	Surface antigen; Region: Bac_surface_Ag; pfam01103
1117647007381	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
1117647007382	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1117647007383	Family of unknown function (DUF490); Region: DUF490; pfam04357
1117647007384	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
1117647007385	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
1117647007386	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647007387	active site
1117647007388	phosphorylation site [posttranslational modification]
1117647007389	intermolecular recognition site; other site
1117647007390	dimerization interface [polypeptide binding]; other site
1117647007391	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647007392	Walker A motif; other site
1117647007393	ATP binding site [chemical binding]; other site
1117647007394	Walker B motif; other site
1117647007395	arginine finger; other site
1117647007396	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1117647007397	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1117647007398	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647007399	putative active site [active]
1117647007400	heme pocket [chemical binding]; other site
1117647007401	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647007402	dimer interface [polypeptide binding]; other site
1117647007403	phosphorylation site [posttranslational modification]
1117647007404	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647007405	ATP binding site [chemical binding]; other site
1117647007406	Mg2+ binding site [ion binding]; other site
1117647007407	G-X-G motif; other site
1117647007408	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
1117647007409	glutamine synthetase; Provisional; Region: glnA; PRK09469
1117647007410	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1117647007411	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1117647007412	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
1117647007413	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1117647007414	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1117647007415	Ligand Binding Site [chemical binding]; other site
1117647007416	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1117647007417	active site residue [active]
1117647007418	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1117647007419	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1117647007420	G1 box; other site
1117647007421	putative GEF interaction site [polypeptide binding]; other site
1117647007422	GTP/Mg2+ binding site [chemical binding]; other site
1117647007423	Switch I region; other site
1117647007424	G2 box; other site
1117647007425	G3 box; other site
1117647007426	Switch II region; other site
1117647007427	G4 box; other site
1117647007428	G5 box; other site
1117647007429	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1117647007430	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1117647007431	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
1117647007432	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
1117647007433	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117647007434	Walker A/P-loop; other site
1117647007435	ATP binding site [chemical binding]; other site
1117647007436	Q-loop/lid; other site
1117647007437	ABC transporter signature motif; other site
1117647007438	Walker B; other site
1117647007439	D-loop; other site
1117647007440	H-loop/switch region; other site
1117647007441	TOBE domain; Region: TOBE; cl01440
1117647007442	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117647007443	putative PBP binding loops; other site
1117647007444	ABC-ATPase subunit interface; other site
1117647007445	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1117647007446	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1117647007447	PilZ domain; Region: PilZ; pfam07238
1117647007448	PilZ domain; Region: PilZ; pfam07238
1117647007449	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1117647007450	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1117647007451	intersubunit interface [polypeptide binding]; other site
1117647007452	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1117647007453	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1117647007454	ABC-ATPase subunit  interface; other site
1117647007455	dimer interface [polypeptide binding]; other site
1117647007456	putative PBP binding regions; other site
1117647007457	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1117647007458	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1117647007459	Walker A/P-loop; other site
1117647007460	ATP binding site [chemical binding]; other site
1117647007461	Q-loop/lid; other site
1117647007462	ABC transporter signature motif; other site
1117647007463	Walker B; other site
1117647007464	D-loop; other site
1117647007465	H-loop/switch region; other site
1117647007466	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1117647007467	amino acid transporter; Region: 2A0306; TIGR00909
1117647007468	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1117647007469	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1117647007470	Helix-turn-helix domain; Region: HTH_18; pfam12833
1117647007471	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1117647007472	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1117647007473	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
1117647007474	putative di-iron ligands [ion binding]; other site
1117647007475	CAAX protease self-immunity; Region: Abi; pfam02517
1117647007476	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
1117647007477	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1117647007478	N-terminal plug; other site
1117647007479	ligand-binding site [chemical binding]; other site
1117647007480	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1117647007481	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
1117647007482	active site
1117647007483	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1117647007484	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1117647007485	active site
1117647007486	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
1117647007487	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1117647007488	PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815
1117647007489	PA/protease or protease-like domain interface [polypeptide binding]; other site
1117647007490	M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883
1117647007491	Peptidase family M28; Region: Peptidase_M28; pfam04389
1117647007492	metal binding site [ion binding]; metal-binding site
1117647007493	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
1117647007494	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
1117647007495	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
1117647007496	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
1117647007497	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1117647007498	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1117647007499	homodimer interface [polypeptide binding]; other site
1117647007500	Walker A motif; other site
1117647007501	ATP binding site [chemical binding]; other site
1117647007502	hydroxycobalamin binding site [chemical binding]; other site
1117647007503	Walker B motif; other site
1117647007504	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1117647007505	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1117647007506	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1117647007507	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1117647007508	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1117647007509	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1117647007510	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
1117647007511	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647007512	active site
1117647007513	phosphorylation site [posttranslational modification]
1117647007514	intermolecular recognition site; other site
1117647007515	dimerization interface [polypeptide binding]; other site
1117647007516	LytTr DNA-binding domain; Region: LytTR; smart00850
1117647007517	Histidine kinase; Region: His_kinase; pfam06580
1117647007518	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1117647007519	Beta-lactamase; Region: Beta-lactamase; pfam00144
1117647007520	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1117647007521	cobyric acid synthase; Provisional; Region: PRK00784
1117647007522	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1117647007523	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1117647007524	catalytic triad [active]
1117647007525	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
1117647007526	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1117647007527	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1117647007528	putative active site [active]
1117647007529	dimerization interface [polypeptide binding]; other site
1117647007530	putative tRNAtyr binding site [nucleotide binding]; other site
1117647007531	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647007532	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
1117647007533	active site
1117647007534	phosphorylation site [posttranslational modification]
1117647007535	intermolecular recognition site; other site
1117647007536	dimerization interface [polypeptide binding]; other site
1117647007537	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1117647007538	Zn2+ binding site [ion binding]; other site
1117647007539	Mg2+ binding site [ion binding]; other site
1117647007540	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1117647007541	DNA-binding site [nucleotide binding]; DNA binding site
1117647007542	RNA-binding motif; other site
1117647007543	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
1117647007544	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
1117647007545	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1117647007546	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1117647007547	metal binding site [ion binding]; metal-binding site
1117647007548	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1117647007549	ABC1 family; Region: ABC1; cl17513
1117647007550	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
1117647007551	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
1117647007552	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1117647007553	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1117647007554	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647007555	S-adenosylmethionine binding site [chemical binding]; other site
1117647007556	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1117647007557	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1117647007558	HlyD family secretion protein; Region: HlyD_3; pfam13437
1117647007559	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
1117647007560	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1117647007561	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1117647007562	dimer interface [polypeptide binding]; other site
1117647007563	putative CheW interface [polypeptide binding]; other site
1117647007564	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1117647007565	active site
1117647007566	HslU subunit interaction site [polypeptide binding]; other site
1117647007567	Sporulation related domain; Region: SPOR; pfam05036
1117647007568	primosome assembly protein PriA; Validated; Region: PRK05580
1117647007569	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117647007570	ATP binding site [chemical binding]; other site
1117647007571	putative Mg++ binding site [ion binding]; other site
1117647007572	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1117647007573	nucleotide binding region [chemical binding]; other site
1117647007574	ATP-binding site [chemical binding]; other site
1117647007575	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
1117647007576	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1117647007577	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1117647007578	putative NAD(P) binding site [chemical binding]; other site
1117647007579	Competence protein A; Region: Competence_A; pfam11104
1117647007580	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1117647007581	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
1117647007582	Protein of unknown function (DUF2681); Region: DUF2681; pfam10883
1117647007583	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
1117647007584	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
1117647007585	Pilus assembly protein, PilP; Region: PilP; pfam04351
1117647007586	AMIN domain; Region: AMIN; pfam11741
1117647007587	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
1117647007588	Secretin and TonB N terminus short domain; Region: STN; smart00965
1117647007589	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1117647007590	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1117647007591	shikimate kinase; Reviewed; Region: aroK; PRK00131
1117647007592	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1117647007593	ADP binding site [chemical binding]; other site
1117647007594	magnesium binding site [ion binding]; other site
1117647007595	putative shikimate binding site; other site
1117647007596	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1117647007597	active site
1117647007598	dimer interface [polypeptide binding]; other site
1117647007599	metal binding site [ion binding]; metal-binding site
1117647007600	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1117647007601	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1117647007602	active site
1117647007603	dimer interface [polypeptide binding]; other site
1117647007604	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1117647007605	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1117647007606	active site
1117647007607	FMN binding site [chemical binding]; other site
1117647007608	substrate binding site [chemical binding]; other site
1117647007609	3Fe-4S cluster binding site [ion binding]; other site
1117647007610	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1117647007611	domain interface; other site
1117647007612	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
1117647007613	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1117647007614	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1117647007615	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1117647007616	substrate binding site [chemical binding]; other site
1117647007617	active site
1117647007618	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
1117647007619	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1117647007620	Zn2+ binding site [ion binding]; other site
1117647007621	Mg2+ binding site [ion binding]; other site
1117647007622	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
1117647007623	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117647007624	S-adenosylmethionine binding site [chemical binding]; other site
1117647007625	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
1117647007626	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1117647007627	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1117647007628	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1117647007629	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1117647007630	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
1117647007631	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1117647007632	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1117647007633	active site residue [active]
1117647007634	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1117647007635	active site residue [active]
1117647007636	GTPase RsgA; Reviewed; Region: PRK12288
1117647007637	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1117647007638	RNA binding site [nucleotide binding]; other site
1117647007639	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1117647007640	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1117647007641	GTP/Mg2+ binding site [chemical binding]; other site
1117647007642	G4 box; other site
1117647007643	G5 box; other site
1117647007644	G1 box; other site
1117647007645	Switch I region; other site
1117647007646	G2 box; other site
1117647007647	G3 box; other site
1117647007648	Switch II region; other site
1117647007649	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1117647007650	catalytic site [active]
1117647007651	putative active site [active]
1117647007652	putative substrate binding site [chemical binding]; other site
1117647007653	dimer interface [polypeptide binding]; other site
1117647007654	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
1117647007655	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
1117647007656	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1117647007657	dimer interface [polypeptide binding]; other site
1117647007658	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1117647007659	active site
1117647007660	Fe binding site [ion binding]; other site
1117647007661	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1117647007662	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1117647007663	Helix-turn-helix domain; Region: HTH_18; pfam12833
1117647007664	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1117647007665	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
1117647007666	endoglucanase; Region: PLN02308
1117647007667	Cellulose binding domain; Region: CBM_3; smart01067
1117647007668	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
1117647007669	Cellulose binding domain; Region: CBM_2; pfam00553
1117647007670	Chitin binding domain; Region: Chitin_bind_3; pfam03067
1117647007671	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
1117647007672	Cellulose binding domain; Region: CBM_2; pfam00553
1117647007673	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647007674	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1117647007675	Walker A motif; other site
1117647007676	ATP binding site [chemical binding]; other site
1117647007677	Walker B motif; other site
1117647007678	arginine finger; other site
1117647007679	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1117647007680	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
1117647007681	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
1117647007682	active site
1117647007683	PEP-CTERM motif; Region: VPEP; pfam07589
1117647007684	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1117647007685	active site
1117647007686	YceI-like domain; Region: YceI; cl01001
1117647007687	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1117647007688	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1117647007689	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1117647007690	putative ATP binding site [chemical binding]; other site
1117647007691	putative substrate interface [chemical binding]; other site
1117647007692	hypothetical protein; Provisional; Region: PRK07524
1117647007693	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1117647007694	PYR/PP interface [polypeptide binding]; other site
1117647007695	dimer interface [polypeptide binding]; other site
1117647007696	TPP binding site [chemical binding]; other site
1117647007697	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1117647007698	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1117647007699	TPP-binding site [chemical binding]; other site
1117647007700	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1117647007701	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1117647007702	putative active site [active]
1117647007703	catalytic triad [active]
1117647007704	PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818
1117647007705	PA/protease or protease-like domain interface [polypeptide binding]; other site
1117647007706	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1117647007707	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1117647007708	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647007709	binding surface
1117647007710	TPR motif; other site
1117647007711	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1117647007712	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647007713	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647007714	metal binding site [ion binding]; metal-binding site
1117647007715	active site
1117647007716	I-site; other site
1117647007717	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1117647007718	catalytic residues [active]
1117647007719	dimer interface [polypeptide binding]; other site
1117647007720	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
1117647007721	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1117647007722	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1117647007723	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1117647007724	Peptidase M15; Region: Peptidase_M15_3; cl01194
1117647007725	putative protease; Provisional; Region: PRK15447
1117647007726	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1117647007727	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1117647007728	Peptidase family U32; Region: Peptidase_U32; pfam01136
1117647007729	Predicted transcriptional regulator [Transcription]; Region: COG2378
1117647007730	HTH domain; Region: HTH_11; pfam08279
1117647007731	WYL domain; Region: WYL; pfam13280
1117647007732	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1117647007733	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1117647007734	Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155
1117647007735	putative active site [active]
1117647007736	catalytic site [active]
1117647007737	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1117647007738	putative active site [active]
1117647007739	catalytic site [active]
1117647007740	Phosphate-starvation-inducible E; Region: PsiE; cl01264
1117647007741	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1117647007742	NAD(P) binding site [chemical binding]; other site
1117647007743	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1117647007744	Ubiquitin-like proteins; Region: UBQ; cl00155
1117647007745	charged pocket; other site
1117647007746	hydrophobic patch; other site
1117647007747	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
1117647007748	TSCPD domain; Region: TSCPD; pfam12637
1117647007749	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1117647007750	MPT binding site; other site
1117647007751	trimer interface [polypeptide binding]; other site
1117647007752	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1117647007753	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1117647007754	FeS/SAM binding site; other site
1117647007755	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1117647007756	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
1117647007757	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1117647007758	active site
1117647007759	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
1117647007760	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1117647007761	NAD(P) binding site [chemical binding]; other site
1117647007762	homotetramer interface [polypeptide binding]; other site
1117647007763	homodimer interface [polypeptide binding]; other site
1117647007764	active site
1117647007765	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
1117647007766	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
1117647007767	Phasin protein; Region: Phasin_2; cl11491
1117647007768	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
1117647007769	polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848
1117647007770	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
1117647007771	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
1117647007772	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117647007773	NAD(P) binding site [chemical binding]; other site
1117647007774	active site
1117647007775	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1117647007776	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1117647007777	Walker A/P-loop; other site
1117647007778	ATP binding site [chemical binding]; other site
1117647007779	Q-loop/lid; other site
1117647007780	ABC transporter signature motif; other site
1117647007781	Walker B; other site
1117647007782	D-loop; other site
1117647007783	H-loop/switch region; other site
1117647007784	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1117647007785	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117647007786	dimer interface [polypeptide binding]; other site
1117647007787	conserved gate region; other site
1117647007788	putative PBP binding loops; other site
1117647007789	ABC-ATPase subunit interface; other site
1117647007790	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1117647007791	NMT1-like family; Region: NMT1_2; pfam13379
1117647007792	NnrS protein; Region: NnrS; pfam05940
1117647007793	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1117647007794	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647007795	putative substrate translocation pore; other site
1117647007796	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647007797	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647007798	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1117647007799	Protein phosphatase 2C; Region: PP2C; pfam00481
1117647007800	active site
1117647007801	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1117647007802	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1117647007803	active site
1117647007804	ATP binding site [chemical binding]; other site
1117647007805	substrate binding site [chemical binding]; other site
1117647007806	activation loop (A-loop); other site
1117647007807	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
1117647007808	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
1117647007809	nif11 domain/cupin domain protein; Region: nif11_cupin; TIGR03890
1117647007810	Rubredoxin [Energy production and conversion]; Region: COG1773
1117647007811	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1117647007812	iron binding site [ion binding]; other site
1117647007813	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
1117647007814	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1117647007815	hypothetical protein; Provisional; Region: PRK07236
1117647007816	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
1117647007817	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
1117647007818	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
1117647007819	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1117647007820	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1117647007821	DEAD_2; Region: DEAD_2; pfam06733
1117647007822	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1117647007823	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1117647007824	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1117647007825	substrate binding pocket [chemical binding]; other site
1117647007826	membrane-bound complex binding site; other site
1117647007827	hinge residues; other site
1117647007828	FOG: CBS domain [General function prediction only]; Region: COG0517
1117647007829	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1117647007830	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
1117647007831	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1117647007832	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
1117647007833	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1117647007834	Heat-labile enterotoxin alpha chain; Region: Enterotoxin_a; pfam01375
1117647007835	Catalytic domain of vertebrate phospholipase D6 and similar proteins; Region: PLDc_vPLD6_like; cd09171
1117647007836	PLD-like domain; Region: PLDc_2; pfam13091
1117647007837	putative active site [active]
1117647007838	catalytic site [active]
1117647007839	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
1117647007840	putative catalytic residues [active]
1117647007841	Cupin domain; Region: Cupin_2; cl17218
1117647007842	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231
1117647007843	putative active site [active]
1117647007844	Zn binding site [ion binding]; other site
1117647007845	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
1117647007846	epoxyqueuosine reductase; Region: TIGR00276
1117647007847	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1117647007848	4Fe-4S binding domain; Region: Fer4; cl02805
1117647007849	putative carbohydrate kinase; Provisional; Region: PRK10565
1117647007850	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
1117647007851	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1117647007852	putative substrate binding site [chemical binding]; other site
1117647007853	putative ATP binding site [chemical binding]; other site
1117647007854	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
1117647007855	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1117647007856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647007857	ATP binding site [chemical binding]; other site
1117647007858	Mg2+ binding site [ion binding]; other site
1117647007859	G-X-G motif; other site
1117647007860	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
1117647007861	ATP binding site [chemical binding]; other site
1117647007862	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1117647007863	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1117647007864	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1117647007865	bacterial Hfq-like; Region: Hfq; cd01716
1117647007866	hexamer interface [polypeptide binding]; other site
1117647007867	Sm1 motif; other site
1117647007868	RNA binding site [nucleotide binding]; other site
1117647007869	Sm2 motif; other site
1117647007870	GTPase HflX; Provisional; Region: PRK11058
1117647007871	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1117647007872	HflX GTPase family; Region: HflX; cd01878
1117647007873	G1 box; other site
1117647007874	GTP/Mg2+ binding site [chemical binding]; other site
1117647007875	Switch I region; other site
1117647007876	G2 box; other site
1117647007877	G3 box; other site
1117647007878	Switch II region; other site
1117647007879	G4 box; other site
1117647007880	G5 box; other site
1117647007881	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
1117647007882	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
1117647007883	HflK protein; Region: hflK; TIGR01933
1117647007884	HflC protein; Region: hflC; TIGR01932
1117647007885	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
1117647007886	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
1117647007887	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
1117647007888	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1117647007889	dimer interface [polypeptide binding]; other site
1117647007890	motif 1; other site
1117647007891	active site
1117647007892	motif 2; other site
1117647007893	motif 3; other site
1117647007894	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1117647007895	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1117647007896	GDP-binding site [chemical binding]; other site
1117647007897	ACT binding site; other site
1117647007898	IMP binding site; other site
1117647007899	Domain of unknown function (DUF389); Region: DUF389; pfam04087
1117647007900	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1117647007901	membrane-bound complex binding site; other site
1117647007902	elongation factor P; Validated; Region: PRK00529
1117647007903	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1117647007904	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1117647007905	RNA binding site [nucleotide binding]; other site
1117647007906	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1117647007907	RNA binding site [nucleotide binding]; other site
1117647007908	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
1117647007909	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
1117647007910	META domain; Region: META; cl01245
1117647007911	VanZ like family; Region: VanZ; pfam04892
1117647007912	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1117647007913	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1117647007914	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1117647007915	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
1117647007916	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
1117647007917	Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934
1117647007918	hypothetical protein; Provisional; Region: PRK04164
1117647007919	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1117647007920	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1117647007921	active site
1117647007922	ribulose/triose binding site [chemical binding]; other site
1117647007923	phosphate binding site [ion binding]; other site
1117647007924	substrate (anthranilate) binding pocket [chemical binding]; other site
1117647007925	product (indole) binding pocket [chemical binding]; other site
1117647007926	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1117647007927	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1117647007928	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1117647007929	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1117647007930	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1117647007931	glutamine binding [chemical binding]; other site
1117647007932	catalytic triad [active]
1117647007933	anthranilate synthase component I; Provisional; Region: PRK13565
1117647007934	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1117647007935	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1117647007936	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1117647007937	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1117647007938	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1117647007939	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1117647007940	substrate binding pocket [chemical binding]; other site
1117647007941	membrane-bound complex binding site; other site
1117647007942	hinge residues; other site
1117647007943	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1117647007944	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117647007945	motif II; other site
1117647007946	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1117647007947	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1117647007948	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
1117647007949	substrate binding site [chemical binding]; other site
1117647007950	hexamer interface [polypeptide binding]; other site
1117647007951	metal binding site [ion binding]; metal-binding site
1117647007952	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1117647007953	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
1117647007954	Substrate binding site; other site
1117647007955	metal-binding site
1117647007956	Phosphotransferase enzyme family; Region: APH; pfam01636
1117647007957	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1117647007958	substrate binding site [chemical binding]; other site
1117647007959	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
1117647007960	OstA-like protein; Region: OstA; cl00844
1117647007961	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1117647007962	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
1117647007963	SurA N-terminal domain; Region: SurA_N; pfam09312
1117647007964	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1117647007965	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1117647007966	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
1117647007967	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1117647007968	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1117647007969	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
1117647007970	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
1117647007971	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
1117647007972	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
1117647007973	active site
1117647007974	metal binding site [ion binding]; metal-binding site
1117647007975	UDP-glucose 4-epimerase; Region: PLN02240
1117647007976	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1117647007977	NAD binding site [chemical binding]; other site
1117647007978	homodimer interface [polypeptide binding]; other site
1117647007979	active site
1117647007980	substrate binding site [chemical binding]; other site
1117647007981	PrkA family serine protein kinase; Provisional; Region: PRK15455
1117647007982	AAA ATPase domain; Region: AAA_16; pfam13191
1117647007983	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
1117647007984	SpoVR family protein; Provisional; Region: PRK11767
1117647007985	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
1117647007986	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647007987	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647007988	active site
1117647007989	phosphorylation site [posttranslational modification]
1117647007990	intermolecular recognition site; other site
1117647007991	dimerization interface [polypeptide binding]; other site
1117647007992	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1117647007993	dimer interface [polypeptide binding]; other site
1117647007994	phosphorylation site [posttranslational modification]
1117647007995	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647007996	ATP binding site [chemical binding]; other site
1117647007997	Mg2+ binding site [ion binding]; other site
1117647007998	G-X-G motif; other site
1117647007999	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
1117647008000	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
1117647008001	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
1117647008002	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1117647008003	ligand binding site [chemical binding]; other site
1117647008004	flexible hinge region; other site
1117647008005	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1117647008006	putative switch regulator; other site
1117647008007	non-specific DNA interactions [nucleotide binding]; other site
1117647008008	DNA binding site [nucleotide binding]
1117647008009	sequence specific DNA binding site [nucleotide binding]; other site
1117647008010	putative cAMP binding site [chemical binding]; other site
1117647008011	OsmC-like protein; Region: OsmC; cl00767
1117647008012	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1117647008013	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
1117647008014	diiron binding motif [ion binding]; other site
1117647008015	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1117647008016	HAMP domain; Region: HAMP; pfam00672
1117647008017	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647008018	putative active site [active]
1117647008019	heme pocket [chemical binding]; other site
1117647008020	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647008021	dimer interface [polypeptide binding]; other site
1117647008022	phosphorylation site [posttranslational modification]
1117647008023	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647008024	ATP binding site [chemical binding]; other site
1117647008025	Mg2+ binding site [ion binding]; other site
1117647008026	G-X-G motif; other site
1117647008027	Ycf46; Provisional; Region: ycf46; CHL00195
1117647008028	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647008029	Walker A motif; other site
1117647008030	ATP binding site [chemical binding]; other site
1117647008031	Walker B motif; other site
1117647008032	arginine finger; other site
1117647008033	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1117647008034	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1117647008035	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1117647008036	Sulfatase; Region: Sulfatase; pfam00884
1117647008037	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1117647008038	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1117647008039	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1117647008040	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1117647008041	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1117647008042	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1117647008043	purine monophosphate binding site [chemical binding]; other site
1117647008044	dimer interface [polypeptide binding]; other site
1117647008045	putative catalytic residues [active]
1117647008046	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1117647008047	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1117647008048	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
1117647008049	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
1117647008050	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
1117647008051	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1117647008052	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1117647008053	DNA binding site [nucleotide binding]
1117647008054	domain linker motif; other site
1117647008055	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
1117647008056	putative dimerization interface [polypeptide binding]; other site
1117647008057	putative ligand binding site [chemical binding]; other site
1117647008058	integron integrase; Region: integrase_gron; TIGR02249
1117647008059	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
1117647008060	Int/Topo IB signature motif; other site
1117647008061	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
1117647008062	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1117647008063	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
1117647008064	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1117647008065	dimerization interface [polypeptide binding]; other site
1117647008066	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1117647008067	HSP70 interaction site [polypeptide binding]; other site
1117647008068	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1117647008069	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1117647008070	HlyD family secretion protein; Region: HlyD_3; pfam13437
1117647008071	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1117647008072	Protein export membrane protein; Region: SecD_SecF; cl14618
1117647008073	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
1117647008074	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1117647008075	active site residue [active]
1117647008076	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647008077	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647008078	active site
1117647008079	phosphorylation site [posttranslational modification]
1117647008080	intermolecular recognition site; other site
1117647008081	dimerization interface [polypeptide binding]; other site
1117647008082	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647008083	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647008084	metal binding site [ion binding]; metal-binding site
1117647008085	active site
1117647008086	I-site; other site
1117647008087	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1117647008088	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1117647008089	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647008090	active site
1117647008091	phosphorylation site [posttranslational modification]
1117647008092	intermolecular recognition site; other site
1117647008093	dimerization interface [polypeptide binding]; other site
1117647008094	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1117647008095	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1117647008096	G1 box; other site
1117647008097	GTP/Mg2+ binding site [chemical binding]; other site
1117647008098	Switch I region; other site
1117647008099	G2 box; other site
1117647008100	G3 box; other site
1117647008101	Switch II region; other site
1117647008102	G4 box; other site
1117647008103	G5 box; other site
1117647008104	Nucleoside recognition; Region: Gate; pfam07670
1117647008105	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1117647008106	FeoA domain; Region: FeoA; pfam04023
1117647008107	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
1117647008108	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1117647008109	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1117647008110	dimer interface [polypeptide binding]; other site
1117647008111	putative functional site; other site
1117647008112	putative MPT binding site; other site
1117647008113	transcriptional regulator NarL; Provisional; Region: PRK10651
1117647008114	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647008115	active site
1117647008116	phosphorylation site [posttranslational modification]
1117647008117	intermolecular recognition site; other site
1117647008118	dimerization interface [polypeptide binding]; other site
1117647008119	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1117647008120	DNA binding residues [nucleotide binding]
1117647008121	dimerization interface [polypeptide binding]; other site
1117647008122	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
1117647008123	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1117647008124	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
1117647008125	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
1117647008126	active site
1117647008127	Zn binding site [ion binding]; other site
1117647008128	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1117647008129	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647008130	GAF domain; Region: GAF; pfam01590
1117647008131	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1117647008132	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117647008133	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647008134	dimer interface [polypeptide binding]; other site
1117647008135	phosphorylation site [posttranslational modification]
1117647008136	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647008137	ATP binding site [chemical binding]; other site
1117647008138	Mg2+ binding site [ion binding]; other site
1117647008139	G-X-G motif; other site
1117647008140	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
1117647008141	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
1117647008142	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1117647008143	dimerization interface [polypeptide binding]; other site
1117647008144	GAF domain; Region: GAF; cl17456
1117647008145	Histidine kinase; Region: HisKA_3; pfam07730
1117647008146	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647008147	ATP binding site [chemical binding]; other site
1117647008148	Mg2+ binding site [ion binding]; other site
1117647008149	G-X-G motif; other site
1117647008150	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1117647008151	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1117647008152	[4Fe-4S] binding site [ion binding]; other site
1117647008153	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1117647008154	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1117647008155	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1117647008156	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1117647008157	molybdopterin cofactor binding site; other site
1117647008158	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1117647008159	4Fe-4S binding domain; Region: Fer4; cl02805
1117647008160	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
1117647008161	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
1117647008162	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1117647008163	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
1117647008164	active site clefts [active]
1117647008165	zinc binding site [ion binding]; other site
1117647008166	dimer interface [polypeptide binding]; other site
1117647008167	CHASE domain; Region: CHASE; pfam03924
1117647008168	PAS domain S-box; Region: sensory_box; TIGR00229
1117647008169	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647008170	putative active site [active]
1117647008171	heme pocket [chemical binding]; other site
1117647008172	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647008173	PAS fold; Region: PAS_3; pfam08447
1117647008174	putative active site [active]
1117647008175	heme pocket [chemical binding]; other site
1117647008176	PAS domain S-box; Region: sensory_box; TIGR00229
1117647008177	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647008178	putative active site [active]
1117647008179	heme pocket [chemical binding]; other site
1117647008180	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1117647008181	GAF domain; Region: GAF; pfam01590
1117647008182	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647008183	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647008184	metal binding site [ion binding]; metal-binding site
1117647008185	active site
1117647008186	I-site; other site
1117647008187	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1117647008188	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109
1117647008189	putative amphipathic alpha helix; other site
1117647008190	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117647008191	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647008192	dimer interface [polypeptide binding]; other site
1117647008193	phosphorylation site [posttranslational modification]
1117647008194	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647008195	ATP binding site [chemical binding]; other site
1117647008196	Mg2+ binding site [ion binding]; other site
1117647008197	G-X-G motif; other site
1117647008198	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647008199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647008200	active site
1117647008201	phosphorylation site [posttranslational modification]
1117647008202	intermolecular recognition site; other site
1117647008203	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1117647008204	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1117647008205	substrate binding pocket [chemical binding]; other site
1117647008206	membrane-bound complex binding site; other site
1117647008207	hinge residues; other site
1117647008208	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1117647008209	active site
1117647008210	ATP binding site [chemical binding]; other site
1117647008211	substrate binding site [chemical binding]; other site
1117647008212	activation loop (A-loop); other site
1117647008213	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647008214	D-galactonate transporter; Region: 2A0114; TIGR00893
1117647008215	putative substrate translocation pore; other site
1117647008216	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
1117647008217	tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812
1117647008218	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1117647008219	catalytic residue [active]
1117647008220	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1117647008221	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1117647008222	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1117647008223	catalytic residue [active]
1117647008224	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
1117647008225	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
1117647008226	active site
1117647008227	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1117647008228	tetramer interface [polypeptide binding]; other site
1117647008229	serine racemase; Region: PLN02970
1117647008230	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647008231	catalytic residue [active]
1117647008232	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
1117647008233	substrate binding site [chemical binding]; other site
1117647008234	Protein of unknown function (DUF521); Region: DUF521; pfam04412
1117647008235	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1117647008236	substrate binding site [chemical binding]; other site
1117647008237	ligand binding site [chemical binding]; other site
1117647008238	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
1117647008239	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
1117647008240	Domain of unknown function (DUF1287); Region: DUF1287; pfam06940
1117647008241	Phosphotransferase enzyme family; Region: APH; pfam01636
1117647008242	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1117647008243	substrate binding site [chemical binding]; other site
1117647008244	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
1117647008245	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1117647008246	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647008247	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117647008248	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647008249	dimer interface [polypeptide binding]; other site
1117647008250	phosphorylation site [posttranslational modification]
1117647008251	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647008252	ATP binding site [chemical binding]; other site
1117647008253	Mg2+ binding site [ion binding]; other site
1117647008254	G-X-G motif; other site
1117647008255	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647008256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647008257	active site
1117647008258	phosphorylation site [posttranslational modification]
1117647008259	intermolecular recognition site; other site
1117647008260	dimerization interface [polypeptide binding]; other site
1117647008261	Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
1117647008262	Protein of unknown function (DUF998); Region: DUF998; pfam06197
1117647008263	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
1117647008264	dimer interface [polypeptide binding]; other site
1117647008265	putative tRNA-binding site [nucleotide binding]; other site
1117647008266	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1117647008267	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1117647008268	E3 interaction surface; other site
1117647008269	lipoyl attachment site [posttranslational modification]; other site
1117647008270	e3 binding domain; Region: E3_binding; pfam02817
1117647008271	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1117647008272	3-methyl-2-oxobutanate dehydrogenase; Provisional; Region: PTZ00182
1117647008273	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1117647008274	alpha subunit interface [polypeptide binding]; other site
1117647008275	TPP binding site [chemical binding]; other site
1117647008276	heterodimer interface [polypeptide binding]; other site
1117647008277	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1117647008278	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1117647008279	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1117647008280	tetramer interface [polypeptide binding]; other site
1117647008281	TPP-binding site [chemical binding]; other site
1117647008282	heterodimer interface [polypeptide binding]; other site
1117647008283	phosphorylation loop region [posttranslational modification]
1117647008284	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1117647008285	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1117647008286	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1117647008287	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647008288	PAS fold; Region: PAS_3; pfam08447
1117647008289	putative active site [active]
1117647008290	heme pocket [chemical binding]; other site
1117647008291	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1117647008292	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1117647008293	dimer interface [polypeptide binding]; other site
1117647008294	putative CheW interface [polypeptide binding]; other site
1117647008295	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1117647008296	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
1117647008297	putative active site [active]
1117647008298	Zn binding site [ion binding]; other site
1117647008299	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
1117647008300	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
1117647008301	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1117647008302	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1117647008303	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1117647008304	Nudix hydrolase homolog; Region: PLN02791
1117647008305	CHASE domain; Region: CHASE; cl01369
1117647008306	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1117647008307	GAF domain; Region: GAF; pfam01590
1117647008308	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1117647008309	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1117647008310	putative active site [active]
1117647008311	heme pocket [chemical binding]; other site
1117647008312	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647008313	dimer interface [polypeptide binding]; other site
1117647008314	phosphorylation site [posttranslational modification]
1117647008315	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647008316	ATP binding site [chemical binding]; other site
1117647008317	Mg2+ binding site [ion binding]; other site
1117647008318	G-X-G motif; other site
1117647008319	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1117647008320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647008321	active site
1117647008322	phosphorylation site [posttranslational modification]
1117647008323	intermolecular recognition site; other site
1117647008324	dimerization interface [polypeptide binding]; other site
1117647008325	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1117647008326	putative binding surface; other site
1117647008327	active site
1117647008328	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
1117647008329	homodimer interface [polypeptide binding]; other site
1117647008330	chemical substrate binding site [chemical binding]; other site
1117647008331	oligomer interface [polypeptide binding]; other site
1117647008332	metal binding site [ion binding]; metal-binding site
1117647008333	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1117647008334	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1117647008335	Walker A/P-loop; other site
1117647008336	ATP binding site [chemical binding]; other site
1117647008337	Q-loop/lid; other site
1117647008338	ABC transporter signature motif; other site
1117647008339	Walker B; other site
1117647008340	D-loop; other site
1117647008341	H-loop/switch region; other site
1117647008342	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1117647008343	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1117647008344	FtsX-like permease family; Region: FtsX; pfam02687
1117647008345	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1117647008346	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1117647008347	FtsX-like permease family; Region: FtsX; pfam02687
1117647008348	anti-sigma E factor; Provisional; Region: rseB; PRK09455
1117647008349	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1117647008350	ATP binding site [chemical binding]; other site
1117647008351	active site
1117647008352	substrate binding site [chemical binding]; other site
1117647008353	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
1117647008354	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
1117647008355	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
1117647008356	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
1117647008357	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1117647008358	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
1117647008359	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
1117647008360	gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521
1117647008361	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1117647008362	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117647008363	Walker A/P-loop; other site
1117647008364	ATP binding site [chemical binding]; other site
1117647008365	Q-loop/lid; other site
1117647008366	ABC transporter signature motif; other site
1117647008367	Walker B; other site
1117647008368	D-loop; other site
1117647008369	H-loop/switch region; other site
1117647008370	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
1117647008371	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
1117647008372	generic binding surface I; other site
1117647008373	generic binding surface II; other site
1117647008374	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
1117647008375	putative active site [active]
1117647008376	putative catalytic site [active]
1117647008377	putative Mg binding site IVb [ion binding]; other site
1117647008378	putative phosphate binding site [ion binding]; other site
1117647008379	putative DNA binding site [nucleotide binding]; other site
1117647008380	putative Mg binding site IVa [ion binding]; other site
1117647008381	multicopper oxidase; Provisional; Region: PRK10965
1117647008382	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
1117647008383	HlyD family secretion protein; Region: HlyD_3; pfam13437
1117647008384	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1117647008385	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
1117647008386	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
1117647008387	Protein of unknown function (DUF1624); Region: DUF1624; pfam07786
1117647008388	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1117647008389	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
1117647008390	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1117647008391	DinB family; Region: DinB; cl17821
1117647008392	DinB superfamily; Region: DinB_2; pfam12867
1117647008393	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
1117647008394	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1117647008395	Walker A/P-loop; other site
1117647008396	ATP binding site [chemical binding]; other site
1117647008397	Q-loop/lid; other site
1117647008398	ABC transporter signature motif; other site
1117647008399	Walker B; other site
1117647008400	D-loop; other site
1117647008401	H-loop/switch region; other site
1117647008402	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1117647008403	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1117647008404	ABC-ATPase subunit  interface; other site
1117647008405	dimer interface [polypeptide binding]; other site
1117647008406	putative PBP binding regions; other site
1117647008407	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
1117647008408	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1117647008409	intersubunit interface [polypeptide binding]; other site
1117647008410	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1117647008411	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1117647008412	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1117647008413	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1117647008414	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1117647008415	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
1117647008416	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1117647008417	N-terminal plug; other site
1117647008418	ligand-binding site [chemical binding]; other site
1117647008419	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
1117647008420	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1117647008421	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1117647008422	substrate binding pocket [chemical binding]; other site
1117647008423	membrane-bound complex binding site; other site
1117647008424	hinge residues; other site
1117647008425	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117647008426	C factor cell-cell signaling protein; Provisional; Region: PRK09009
1117647008427	NAD(P) binding site [chemical binding]; other site
1117647008428	active site
1117647008429	Protein of unknown function, DUF393; Region: DUF393; pfam04134
1117647008430	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
1117647008431	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
1117647008432	DNA photolyase; Region: DNA_photolyase; pfam00875
1117647008433	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
1117647008434	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
1117647008435	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647008436	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1117647008437	N-terminal plug; other site
1117647008438	ligand-binding site [chemical binding]; other site
1117647008439	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1117647008440	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1117647008441	Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classI; cd00643
1117647008442	tetramerization interface [polypeptide binding]; other site
1117647008443	substrate binding pocket [chemical binding]; other site
1117647008444	catalytic residues [active]
1117647008445	inhibitor binding sites; inhibition site
1117647008446	NADP(H) binding site [chemical binding]; other site
1117647008447	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647008448	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1117647008449	putative substrate translocation pore; other site
1117647008450	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1117647008451	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1117647008452	acyl-activating enzyme (AAE) consensus motif; other site
1117647008453	AMP binding site [chemical binding]; other site
1117647008454	active site
1117647008455	CoA binding site [chemical binding]; other site
1117647008456	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1117647008457	active site
1117647008458	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
1117647008459	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1117647008460	putative active site [active]
1117647008461	metal binding site [ion binding]; metal-binding site
1117647008462	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1117647008463	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1117647008464	active site
1117647008465	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1117647008466	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1117647008467	MgtE intracellular N domain; Region: MgtE_N; pfam03448
1117647008468	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1117647008469	Divalent cation transporter; Region: MgtE; pfam01769
1117647008470	universal stress protein UspE; Provisional; Region: PRK11175
1117647008471	Universal stress protein family; Region: Usp; pfam00582
1117647008472	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1117647008473	Ligand Binding Site [chemical binding]; other site
1117647008474	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
1117647008475	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1117647008476	Beta-Casp domain; Region: Beta-Casp; smart01027
1117647008477	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1117647008478	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1117647008479	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1117647008480	transcriptional regulator; Provisional; Region: PRK10632
1117647008481	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117647008482	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1117647008483	putative effector binding pocket; other site
1117647008484	dimerization interface [polypeptide binding]; other site
1117647008485	Predicted membrane protein [Function unknown]; Region: COG2259
1117647008486	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1117647008487	putative active site [active]
1117647008488	metal binding site [ion binding]; metal-binding site
1117647008489	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
1117647008490	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
1117647008491	conserved cys residue [active]
1117647008492	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
1117647008493	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1117647008494	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1117647008495	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1117647008496	dimerization interface [polypeptide binding]; other site
1117647008497	putative Zn2+ binding site [ion binding]; other site
1117647008498	putative DNA binding site [nucleotide binding]; other site
1117647008499	Predicted membrane protein [Function unknown]; Region: COG2119
1117647008500	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1117647008501	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1117647008502	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1117647008503	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1117647008504	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1117647008505	protein binding site [polypeptide binding]; other site
1117647008506	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1117647008507	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1117647008508	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1117647008509	putative dimer interface [polypeptide binding]; other site
1117647008510	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1117647008511	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1117647008512	putative dimer interface [polypeptide binding]; other site
1117647008513	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1117647008514	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1117647008515	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
1117647008516	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
1117647008517	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117647008518	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1117647008519	DNA binding residues [nucleotide binding]
1117647008520	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
1117647008521	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1117647008522	NAD binding site [chemical binding]; other site
1117647008523	active site
1117647008524	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
1117647008525	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1117647008526	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1117647008527	iron-sulfur cluster [ion binding]; other site
1117647008528	[2Fe-2S] cluster binding site [ion binding]; other site
1117647008529	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1117647008530	hydrophobic ligand binding site; other site
1117647008531	hypothetical protein; Provisional; Region: PRK06849
1117647008532	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1117647008533	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1117647008534	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
1117647008535	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
1117647008536	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1117647008537	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1117647008538	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117647008539	NAD(P) binding site [chemical binding]; other site
1117647008540	active site
1117647008541	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204
1117647008542	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1117647008543	dimer interface [polypeptide binding]; other site
1117647008544	active site
1117647008545	CoA binding pocket [chemical binding]; other site
1117647008546	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1117647008547	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1117647008548	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1117647008549	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1117647008550	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1117647008551	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835
1117647008552	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1117647008553	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1117647008554	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1117647008555	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
1117647008556	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1117647008557	carboxyltransferase (CT) interaction site; other site
1117647008558	biotinylation site [posttranslational modification]; other site
1117647008559	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1117647008560	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
1117647008561	dimer interface [polypeptide binding]; other site
1117647008562	metal binding site [ion binding]; metal-binding site
1117647008563	substrate binding site [chemical binding]; other site
1117647008564	membrane ATPase/protein kinase; Provisional; Region: PRK09435
1117647008565	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
1117647008566	Walker A; other site
1117647008567	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
1117647008568	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1117647008569	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1117647008570	substrate binding pocket [chemical binding]; other site
1117647008571	membrane-bound complex binding site; other site
1117647008572	hinge residues; other site
1117647008573	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1117647008574	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
1117647008575	active site flap/lid [active]
1117647008576	nucleophilic elbow; other site
1117647008577	catalytic triad [active]
1117647008578	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1117647008579	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1117647008580	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1117647008581	Sulfatase; Region: Sulfatase; cl17466
1117647008582	Sulfatase; Region: Sulfatase; cl17466
1117647008583	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1117647008584	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647008585	putative substrate translocation pore; other site
1117647008586	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1117647008587	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1117647008588	putative substrate binding site [chemical binding]; other site
1117647008589	putative ATP binding site [chemical binding]; other site
1117647008590	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
1117647008591	dimerization interface [polypeptide binding]; other site
1117647008592	putative active cleft [active]
1117647008593	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
1117647008594	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
1117647008595	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1117647008596	Na binding site [ion binding]; other site
1117647008597	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
1117647008598	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
1117647008599	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
1117647008600	VPS10 domain; Region: VPS10; smart00602
1117647008601	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1117647008602	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1117647008603	active site
1117647008604	catalytic residues [active]
1117647008605	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1117647008606	This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511
1117647008607	putative di-iron ligands [ion binding]; other site
1117647008608	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
1117647008609	[2Fe-2S] cluster binding site [ion binding]; other site
1117647008610	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
1117647008611	FAD binding pocket [chemical binding]; other site
1117647008612	FAD binding motif [chemical binding]; other site
1117647008613	phosphate binding motif [ion binding]; other site
1117647008614	beta-alpha-beta structure motif; other site
1117647008615	NAD binding pocket [chemical binding]; other site
1117647008616	triosephosphate isomerase; Provisional; Region: PRK14567
1117647008617	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1117647008618	substrate binding site [chemical binding]; other site
1117647008619	dimer interface [polypeptide binding]; other site
1117647008620	catalytic triad [active]
1117647008621	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
1117647008622	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1117647008623	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1117647008624	MFS/sugar transport protein; Region: MFS_2; pfam13347
1117647008625	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1117647008626	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1117647008627	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647008628	putative substrate translocation pore; other site
1117647008629	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1117647008630	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1117647008631	nucleotide binding site [chemical binding]; other site
1117647008632	Uncharacterized conserved protein [Function unknown]; Region: COG3538
1117647008633	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
1117647008634	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1117647008635	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1117647008636	active site
1117647008637	dimer interface [polypeptide binding]; other site
1117647008638	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1117647008639	dimer interface [polypeptide binding]; other site
1117647008640	active site
1117647008641	Predicted peptidase [General function prediction only]; Region: COG4099
1117647008642	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1117647008643	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1117647008644	nucleotide binding site [chemical binding]; other site
1117647008645	short chain dehydrogenase; Validated; Region: PRK08324
1117647008646	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
1117647008647	active site
1117647008648	Zn2+ binding site [ion binding]; other site
1117647008649	intersubunit interface [polypeptide binding]; other site
1117647008650	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117647008651	NAD(P) binding site [chemical binding]; other site
1117647008652	active site
1117647008653	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
1117647008654	L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629
1117647008655	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1117647008656	active site
1117647008657	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1117647008658	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
1117647008659	Cupin domain; Region: Cupin_2; pfam07883
1117647008660	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1117647008661	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1117647008662	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1117647008663	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1117647008664	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1117647008665	SapC; Region: SapC; pfam07277
1117647008666	Family description; Region: VCBS; pfam13517
1117647008667	Family description; Region: VCBS; pfam13517
1117647008668	Family description; Region: VCBS; pfam13517
1117647008669	Family description; Region: VCBS; pfam13517
1117647008670	Family description; Region: VCBS; pfam13517
1117647008671	Family description; Region: VCBS; pfam13517
1117647008672	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
1117647008673	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1117647008674	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
1117647008675	active site
1117647008676	Sulfatase; Region: Sulfatase; cl17466
1117647008677	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1117647008678	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
1117647008679	active site
1117647008680	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1117647008681	Cysteine-rich domain; Region: CCG; pfam02754
1117647008682	Cysteine-rich domain; Region: CCG; pfam02754
1117647008683	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
1117647008684	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1117647008685	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1117647008686	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
1117647008687	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1117647008688	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1117647008689	Interdomain contacts; other site
1117647008690	Cytokine receptor motif; other site
1117647008691	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1117647008692	Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561
1117647008693	active site
1117647008694	catalytic triad [active]
1117647008695	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1117647008696	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117647008697	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1117647008698	DNA binding residues [nucleotide binding]
1117647008699	putative S-transferase; Provisional; Region: PRK11752
1117647008700	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1117647008701	C-terminal domain interface [polypeptide binding]; other site
1117647008702	GSH binding site (G-site) [chemical binding]; other site
1117647008703	dimer interface [polypeptide binding]; other site
1117647008704	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
1117647008705	dimer interface [polypeptide binding]; other site
1117647008706	N-terminal domain interface [polypeptide binding]; other site
1117647008707	active site
1117647008708	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647008709	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
1117647008710	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647008711	phosphomannomutase CpsG; Provisional; Region: PRK15414
1117647008712	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1117647008713	active site
1117647008714	substrate binding site [chemical binding]; other site
1117647008715	metal binding site [ion binding]; metal-binding site
1117647008716	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
1117647008717	dimerization interface [polypeptide binding]; other site
1117647008718	putative active cleft [active]
1117647008719	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1117647008720	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1117647008721	DNA binding site [nucleotide binding]
1117647008722	domain linker motif; other site
1117647008723	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
1117647008724	dimerization interface [polypeptide binding]; other site
1117647008725	ligand binding site [chemical binding]; other site
1117647008726	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
1117647008727	Na binding site [ion binding]; other site
1117647008728	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1117647008729	active site
1117647008730	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
1117647008731	dimerization interface [polypeptide binding]; other site
1117647008732	putative active cleft [active]
1117647008733	Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934
1117647008734	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
1117647008735	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1117647008736	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1117647008737	active site
1117647008738	dimer interface [polypeptide binding]; other site
1117647008739	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1117647008740	dimer interface [polypeptide binding]; other site
1117647008741	active site
1117647008742	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1117647008743	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1117647008744	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
1117647008745	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647008746	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647008747	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
1117647008748	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
1117647008749	active site
1117647008750	catalytic residues [active]
1117647008751	catalytic residues [active]
1117647008752	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1117647008753	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1117647008754	NAD(P) binding site [chemical binding]; other site
1117647008755	catalytic residues [active]
1117647008756	enoyl-CoA hydratase; Provisional; Region: PRK07658
1117647008757	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1117647008758	substrate binding site [chemical binding]; other site
1117647008759	oxyanion hole (OAH) forming residues; other site
1117647008760	trimer interface [polypeptide binding]; other site
1117647008761	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1117647008762	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1117647008763	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1117647008764	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1117647008765	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1117647008766	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1117647008767	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
1117647008768	Bacterial transcriptional regulator; Region: IclR; pfam01614
1117647008769	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
1117647008770	Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178
1117647008771	calcium binding site [ion binding]; other site
1117647008772	active site
1117647008773	catalytic residues [active]
1117647008774	Carbohydrate Binding Module 6 (CBM6); appended mainly to glycoside hydrolase (GH) family 16 alpha- and beta agarases; Region: CBM6_agarase-like; cd04079
1117647008775	Ca binding site [ion binding]; other site
1117647008776	ligand binding site [chemical binding]; other site
1117647008777	Carbohydrate Binding Module 6 (CBM6); appended mainly to glycoside hydrolase (GH) family 16 alpha- and beta agarases; Region: CBM6_agarase-like; cd04079
1117647008778	Ca binding site [ion binding]; other site
1117647008779	ligand binding site [chemical binding]; other site
1117647008780	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1117647008781	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1117647008782	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1117647008783	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1117647008784	substrate binding site [chemical binding]; other site
1117647008785	ATP binding site [chemical binding]; other site
1117647008786	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647008787	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
1117647008788	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647008789	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647008790	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1117647008791	NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078
1117647008792	NAD(P) binding site [chemical binding]; other site
1117647008793	catalytic residues [active]
1117647008794	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1117647008795	Phosphotransferase enzyme family; Region: APH; pfam01636
1117647008796	active site
1117647008797	substrate binding site [chemical binding]; other site
1117647008798	ATP binding site [chemical binding]; other site
1117647008799	enolase; Provisional; Region: eno; PRK00077
1117647008800	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1117647008801	dimer interface [polypeptide binding]; other site
1117647008802	metal binding site [ion binding]; metal-binding site
1117647008803	substrate binding pocket [chemical binding]; other site
1117647008804	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1117647008805	Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956
1117647008806	NodB motif; other site
1117647008807	putative active site [active]
1117647008808	putative catalytic site [active]
1117647008809	putative Zn binding site [ion binding]; other site
1117647008810	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
1117647008811	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1117647008812	active site
1117647008813	intersubunit interface [polypeptide binding]; other site
1117647008814	catalytic residue [active]
1117647008815	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647008816	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
1117647008817	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1117647008818	classical (c) SDRs; Region: SDR_c; cd05233
1117647008819	NAD(P) binding site [chemical binding]; other site
1117647008820	active site
1117647008821	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1117647008822	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1117647008823	active site pocket [active]
1117647008824	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1117647008825	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1117647008826	active site pocket [active]
1117647008827	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1117647008828	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1117647008829	NAD(P) binding site [chemical binding]; other site
1117647008830	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
1117647008831	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1117647008832	NADP binding site [chemical binding]; other site
1117647008833	homodimer interface [polypeptide binding]; other site
1117647008834	active site
1117647008835	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
1117647008836	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1117647008837	NAD binding site [chemical binding]; other site
1117647008838	catalytic residues [active]
1117647008839	substrate binding site [chemical binding]; other site
1117647008840	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1117647008841	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1117647008842	DNA-binding site [nucleotide binding]; DNA binding site
1117647008843	FCD domain; Region: FCD; pfam07729
1117647008844	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
1117647008845	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
1117647008846	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1117647008847	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
1117647008848	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647008849	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647008850	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
1117647008851	SapC; Region: SapC; pfam07277
1117647008852	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647008853	D-galactonate transporter; Region: 2A0114; TIGR00893
1117647008854	putative substrate translocation pore; other site
1117647008855	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1117647008856	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1117647008857	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1117647008858	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
1117647008859	heme binding site [chemical binding]; other site
1117647008860	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
1117647008861	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1117647008862	choice-of-anchor B domain; Region: choice_anch_B; TIGR04312
1117647008863	glutathione s-transferase; Provisional; Region: PTZ00057
1117647008864	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
1117647008865	GSH binding site (G-site) [chemical binding]; other site
1117647008866	C-terminal domain interface [polypeptide binding]; other site
1117647008867	dimer interface [polypeptide binding]; other site
1117647008868	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1117647008869	N-terminal domain interface [polypeptide binding]; other site
1117647008870	dimer interface [polypeptide binding]; other site
1117647008871	substrate binding pocket (H-site) [chemical binding]; other site
1117647008872	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1117647008873	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1117647008874	substrate binding pocket [chemical binding]; other site
1117647008875	membrane-bound complex binding site; other site
1117647008876	hinge residues; other site
1117647008877	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
1117647008878	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1117647008879	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1117647008880	catalytic residue [active]
1117647008881	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1117647008882	catalytic residues [active]
1117647008883	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1117647008884	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1117647008885	peroxiredoxin; Region: AhpC; TIGR03137
1117647008886	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1117647008887	dimer interface [polypeptide binding]; other site
1117647008888	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1117647008889	catalytic triad [active]
1117647008890	peroxidatic and resolving cysteines [active]
1117647008891	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1117647008892	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117647008893	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1117647008894	dimerization interface [polypeptide binding]; other site
1117647008895	malic enzyme; Reviewed; Region: PRK12862
1117647008896	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1117647008897	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1117647008898	putative NAD(P) binding site [chemical binding]; other site
1117647008899	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1117647008900	SnoaL-like domain; Region: SnoaL_3; pfam13474
1117647008901	5'-nucleotidase; Provisional; Region: PRK03826
1117647008902	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1117647008903	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1117647008904	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1117647008905	Na2 binding site [ion binding]; other site
1117647008906	putative substrate binding site 1 [chemical binding]; other site
1117647008907	Na binding site 1 [ion binding]; other site
1117647008908	putative substrate binding site 2 [chemical binding]; other site
1117647008909	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1117647008910	Na2 binding site [ion binding]; other site
1117647008911	putative substrate binding site 1 [chemical binding]; other site
1117647008912	Na binding site 1 [ion binding]; other site
1117647008913	putative substrate binding site 2 [chemical binding]; other site
1117647008914	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
1117647008915	putative coenzyme Q binding site [chemical binding]; other site
1117647008916	RnfH family Ubiquitin; Region: Ub-RnfH; cl17382
1117647008917	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
1117647008918	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
1117647008919	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1117647008920	metal binding site 2 [ion binding]; metal-binding site
1117647008921	putative DNA binding helix; other site
1117647008922	metal binding site 1 [ion binding]; metal-binding site
1117647008923	dimer interface [polypeptide binding]; other site
1117647008924	structural Zn2+ binding site [ion binding]; other site
1117647008925	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1117647008926	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1117647008927	Walker A/P-loop; other site
1117647008928	ATP binding site [chemical binding]; other site
1117647008929	Q-loop/lid; other site
1117647008930	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1117647008931	ABC transporter signature motif; other site
1117647008932	Walker B; other site
1117647008933	D-loop; other site
1117647008934	H-loop/switch region; other site
1117647008935	GrpE; Region: GrpE; pfam01025
1117647008936	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1117647008937	dimer interface [polypeptide binding]; other site
1117647008938	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1117647008939	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1117647008940	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1117647008941	nucleotide binding site [chemical binding]; other site
1117647008942	chaperone protein DnaJ; Provisional; Region: PRK10767
1117647008943	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1117647008944	HSP70 interaction site [polypeptide binding]; other site
1117647008945	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1117647008946	substrate binding site [polypeptide binding]; other site
1117647008947	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1117647008948	Zn binding sites [ion binding]; other site
1117647008949	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1117647008950	dimer interface [polypeptide binding]; other site
1117647008951	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1117647008952	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1117647008953	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1117647008954	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
1117647008955	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1117647008956	dimerization interface [polypeptide binding]; other site
1117647008957	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1117647008958	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1117647008959	dimer interface [polypeptide binding]; other site
1117647008960	putative CheW interface [polypeptide binding]; other site
1117647008961	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1117647008962	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1117647008963	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1117647008964	catalytic site [active]
1117647008965	subunit interface [polypeptide binding]; other site
1117647008966	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1117647008967	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1117647008968	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1117647008969	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1117647008970	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1117647008971	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1117647008972	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1117647008973	IMP binding site; other site
1117647008974	dimer interface [polypeptide binding]; other site
1117647008975	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1117647008976	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1117647008977	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1117647008978	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
1117647008979	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1117647008980	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1117647008981	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647008982	homodimer interface [polypeptide binding]; other site
1117647008983	catalytic residue [active]
1117647008984	Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney,  using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144
1117647008985	putative FMN binding site [chemical binding]; other site
1117647008986	putative dimer interface [polypeptide binding]; other site
1117647008987	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
1117647008988	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1117647008989	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1117647008990	catalytic residue [active]
1117647008991	Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700
1117647008992	K+-transporting ATPase, c chain; Region: KdpC; cl00944
1117647008993	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1117647008994	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1117647008995	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647008996	homodimer interface [polypeptide binding]; other site
1117647008997	catalytic residue [active]
1117647008998	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
1117647008999	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647009000	Walker A motif; other site
1117647009001	ATP binding site [chemical binding]; other site
1117647009002	Walker B motif; other site
1117647009003	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1117647009004	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1117647009005	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1117647009006	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1117647009007	Predicted methyltransferase [General function prediction only]; Region: COG4798
1117647009008	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1117647009009	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1117647009010	Sel1-like repeats; Region: SEL1; smart00671
1117647009011	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1117647009012	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1117647009013	Lipopolysaccharide-assembly; Region: LptE; cl01125
1117647009014	Protein of unknown function (DUF1451); Region: DUF1451; pfam07295
1117647009015	Amidinotransferase; Region: Amidinotransf; cl12043
1117647009016	FOG: CBS domain [General function prediction only]; Region: COG0517
1117647009017	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
1117647009018	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647009019	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647009020	metal binding site [ion binding]; metal-binding site
1117647009021	active site
1117647009022	I-site; other site
1117647009023	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1117647009024	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1117647009025	putative active site [active]
1117647009026	catalytic triad [active]
1117647009027	putative dimer interface [polypeptide binding]; other site
1117647009028	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
1117647009029	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1117647009030	Transporter associated domain; Region: CorC_HlyC; smart01091
1117647009031	metal-binding heat shock protein; Provisional; Region: PRK00016
1117647009032	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1117647009033	PhoH-like protein; Region: PhoH; pfam02562
1117647009034	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
1117647009035	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1117647009036	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1117647009037	FeS/SAM binding site; other site
1117647009038	TRAM domain; Region: TRAM; pfam01938
1117647009039	Domain of unknown function (DUF1820); Region: DUF1820; cl11545
1117647009040	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1117647009041	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1117647009042	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1117647009043	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1117647009044	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
1117647009045	TrkA-N domain; Region: TrkA_N; pfam02254
1117647009046	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
1117647009047	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
1117647009048	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1117647009049	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1117647009050	catalytic residue [active]
1117647009051	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1117647009052	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117647009053	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
1117647009054	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1117647009055	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1117647009056	HlyD family secretion protein; Region: HlyD_3; pfam13437
1117647009057	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1117647009058	Protein export membrane protein; Region: SecD_SecF; cl14618
1117647009059	Protein of unknown function (DUF962); Region: DUF962; pfam06127
1117647009060	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1117647009061	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1117647009062	substrate binding pocket [chemical binding]; other site
1117647009063	membrane-bound complex binding site; other site
1117647009064	hinge residues; other site
1117647009065	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1117647009066	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1117647009067	substrate binding pocket [chemical binding]; other site
1117647009068	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117647009069	Coenzyme A binding pocket [chemical binding]; other site
1117647009070	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
1117647009071	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1117647009072	putative C-terminal domain interface [polypeptide binding]; other site
1117647009073	putative GSH binding site (G-site) [chemical binding]; other site
1117647009074	putative dimer interface [polypeptide binding]; other site
1117647009075	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
1117647009076	putative dimer interface [polypeptide binding]; other site
1117647009077	putative N-terminal domain interface [polypeptide binding]; other site
1117647009078	putative substrate binding pocket (H-site) [chemical binding]; other site
1117647009079	Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461
1117647009080	active site
1117647009081	Zn binding site [ion binding]; other site
1117647009082	POT family; Region: PTR2; cl17359
1117647009083	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1117647009084	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
1117647009085	TPR repeat; Region: TPR_11; pfam13414
1117647009086	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647009087	binding surface
1117647009088	TPR motif; other site
1117647009089	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1117647009090	TPR repeat; Region: TPR_11; pfam13414
1117647009091	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1117647009092	binding surface
1117647009093	TPR motif; other site
1117647009094	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
1117647009095	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1117647009096	TPR motif; other site
1117647009097	binding surface
1117647009098	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759
1117647009099	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
1117647009100	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647009101	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647009102	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647009103	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647009104	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647009105	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647009106	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
1117647009107	FecR protein; Region: FecR; pfam04773
1117647009108	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1117647009109	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117647009110	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1117647009111	DNA binding residues [nucleotide binding]
1117647009112	HDOD domain; Region: HDOD; pfam08668
1117647009113	CHASE4 domain; Region: CHASE4; pfam05228
1117647009114	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647009115	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647009116	metal binding site [ion binding]; metal-binding site
1117647009117	active site
1117647009118	I-site; other site
1117647009119	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1117647009120	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1117647009121	ATP binding site [chemical binding]; other site
1117647009122	Mg++ binding site [ion binding]; other site
1117647009123	motif III; other site
1117647009124	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117647009125	nucleotide binding region [chemical binding]; other site
1117647009126	ATP-binding site [chemical binding]; other site
1117647009127	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1117647009128	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1117647009129	active site
1117647009130	phosphorylation site [posttranslational modification]
1117647009131	intermolecular recognition site; other site
1117647009132	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647009133	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647009134	active site
1117647009135	phosphorylation site [posttranslational modification]
1117647009136	intermolecular recognition site; other site
1117647009137	dimerization interface [polypeptide binding]; other site
1117647009138	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647009139	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647009140	metal binding site [ion binding]; metal-binding site
1117647009141	active site
1117647009142	I-site; other site
1117647009143	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
1117647009144	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1117647009145	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1117647009146	GatB domain; Region: GatB_Yqey; smart00845
1117647009147	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1117647009148	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1117647009149	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1117647009150	rod shape-determining protein MreB; Provisional; Region: PRK13927
1117647009151	MreB and similar proteins; Region: MreB_like; cd10225
1117647009152	nucleotide binding site [chemical binding]; other site
1117647009153	Mg binding site [ion binding]; other site
1117647009154	putative protofilament interaction site [polypeptide binding]; other site
1117647009155	RodZ interaction site [polypeptide binding]; other site
1117647009156	rod shape-determining protein MreC; Provisional; Region: PRK13922
1117647009157	Kinesin motor; Region: Kinesin-relat_1; pfam12711
1117647009158	rod shape-determining protein MreC; Region: MreC; pfam04085
1117647009159	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
1117647009160	Maf-like protein; Region: Maf; pfam02545
1117647009161	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1117647009162	active site
1117647009163	dimer interface [polypeptide binding]; other site
1117647009164	ribonuclease G; Provisional; Region: PRK11712
1117647009165	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1117647009166	homodimer interface [polypeptide binding]; other site
1117647009167	oligonucleotide binding site [chemical binding]; other site
1117647009168	TIGR02099 family protein; Region: TIGR02099
1117647009169	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1117647009170	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
1117647009171	SelR domain; Region: SelR; pfam01641
1117647009172	Predicted membrane protein [Function unknown]; Region: COG2860
1117647009173	UPF0126 domain; Region: UPF0126; pfam03458
1117647009174	UPF0126 domain; Region: UPF0126; pfam03458
1117647009175	hypothetical protein; Provisional; Region: PRK05255
1117647009176	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1117647009177	dimerization domain swap beta strand [polypeptide binding]; other site
1117647009178	regulatory protein interface [polypeptide binding]; other site
1117647009179	active site
1117647009180	regulatory phosphorylation site [posttranslational modification]; other site
1117647009181	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1117647009182	AAA domain; Region: AAA_18; pfam13238
1117647009183	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1117647009184	active site
1117647009185	phosphorylation site [posttranslational modification]
1117647009186	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1117647009187	30S subunit binding site; other site
1117647009188	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1117647009189	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1117647009190	Walker A/P-loop; other site
1117647009191	ATP binding site [chemical binding]; other site
1117647009192	Q-loop/lid; other site
1117647009193	ABC transporter signature motif; other site
1117647009194	Walker B; other site
1117647009195	D-loop; other site
1117647009196	H-loop/switch region; other site
1117647009197	OstA-like protein; Region: OstA; cl00844
1117647009198	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
1117647009199	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1117647009200	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
1117647009201	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1117647009202	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
1117647009203	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1117647009204	putative active site [active]
1117647009205	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1117647009206	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
1117647009207	BolA-like protein; Region: BolA; cl00386
1117647009208	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1117647009209	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1117647009210	hinge; other site
1117647009211	active site
1117647009212	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1117647009213	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1117647009214	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1117647009215	histidinol dehydrogenase; Region: hisD; TIGR00069
1117647009216	NAD binding site [chemical binding]; other site
1117647009217	dimerization interface [polypeptide binding]; other site
1117647009218	product binding site; other site
1117647009219	substrate binding site [chemical binding]; other site
1117647009220	zinc binding site [ion binding]; other site
1117647009221	catalytic residues [active]
1117647009222	serine endoprotease; Provisional; Region: PRK10898
1117647009223	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1117647009224	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1117647009225	protein binding site [polypeptide binding]; other site
1117647009226	Protein of unknown function (DUF1043); Region: DUF1043; cl11473
1117647009227	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
1117647009228	Predicted ATPase [General function prediction only]; Region: COG1485
1117647009229	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1117647009230	23S rRNA interface [nucleotide binding]; other site
1117647009231	L3 interface [polypeptide binding]; other site
1117647009232	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1117647009233	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
1117647009234	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
1117647009235	[2Fe-2S] cluster binding site [ion binding]; other site
1117647009236	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1117647009237	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
1117647009238	Qi binding site; other site
1117647009239	intrachain domain interface; other site
1117647009240	interchain domain interface [polypeptide binding]; other site
1117647009241	heme bH binding site [chemical binding]; other site
1117647009242	heme bL binding site [chemical binding]; other site
1117647009243	Qo binding site; other site
1117647009244	interchain domain interface [polypeptide binding]; other site
1117647009245	intrachain domain interface; other site
1117647009246	Qi binding site; other site
1117647009247	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
1117647009248	Qo binding site; other site
1117647009249	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
1117647009250	stringent starvation protein A; Provisional; Region: sspA; PRK09481
1117647009251	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
1117647009252	C-terminal domain interface [polypeptide binding]; other site
1117647009253	putative GSH binding site (G-site) [chemical binding]; other site
1117647009254	dimer interface [polypeptide binding]; other site
1117647009255	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
1117647009256	dimer interface [polypeptide binding]; other site
1117647009257	N-terminal domain interface [polypeptide binding]; other site
1117647009258	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
1117647009259	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1117647009260	S1 domain; Region: S1_2; pfam13509
1117647009261	S1 domain; Region: S1_2; pfam13509
1117647009262	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1117647009263	RNA binding site [nucleotide binding]; other site
1117647009264	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1117647009265	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1117647009266	dimer interface [polypeptide binding]; other site
1117647009267	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647009268	catalytic residue [active]
1117647009269	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
1117647009270	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1117647009271	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1117647009272	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1117647009273	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1117647009274	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1117647009275	putative valine binding site [chemical binding]; other site
1117647009276	dimer interface [polypeptide binding]; other site
1117647009277	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1117647009278	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1117647009279	Clp amino terminal domain; Region: Clp_N; pfam02861
1117647009280	Clp amino terminal domain; Region: Clp_N; pfam02861
1117647009281	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647009282	Walker A motif; other site
1117647009283	ATP binding site [chemical binding]; other site
1117647009284	Walker B motif; other site
1117647009285	arginine finger; other site
1117647009286	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647009287	Walker A motif; other site
1117647009288	ATP binding site [chemical binding]; other site
1117647009289	Walker B motif; other site
1117647009290	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1117647009291	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
1117647009292	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1117647009293	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
1117647009294	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1117647009295	RNA binding surface [nucleotide binding]; other site
1117647009296	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1117647009297	active site
1117647009298	Outer membrane lipoprotein; Region: YfiO; pfam13525
1117647009299	Peptidase family M48; Region: Peptidase_M48; cl12018
1117647009300	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
1117647009301	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
1117647009302	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1117647009303	dimer interface [polypeptide binding]; other site
1117647009304	active site
1117647009305	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
1117647009306	BON domain; Region: BON; pfam04972
1117647009307	BON domain; Region: BON; cl02771
1117647009308	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1117647009309	dimer interface [polypeptide binding]; other site
1117647009310	active site
1117647009311	hypothetical protein; Reviewed; Region: PRK12497
1117647009312	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
1117647009313	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
1117647009314	putative ligand binding site [chemical binding]; other site
1117647009315	Predicted methyltransferases [General function prediction only]; Region: COG0313
1117647009316	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1117647009317	putative SAM binding site [chemical binding]; other site
1117647009318	putative homodimer interface [polypeptide binding]; other site
1117647009319	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1117647009320	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1117647009321	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1117647009322	N-terminal plug; other site
1117647009323	ligand-binding site [chemical binding]; other site
1117647009324	MraW methylase family; Region: Methyltransf_5; cl17771
1117647009325	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1117647009326	Cell division protein FtsL; Region: FtsL; pfam04999
1117647009327	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1117647009328	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1117647009329	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1117647009330	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1117647009331	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1117647009332	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1117647009333	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1117647009334	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1117647009335	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
1117647009336	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1117647009337	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1117647009338	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1117647009339	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1117647009340	Mg++ binding site [ion binding]; other site
1117647009341	putative catalytic motif [active]
1117647009342	putative substrate binding site [chemical binding]; other site
1117647009343	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
1117647009344	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1117647009345	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1117647009346	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1117647009347	cell division protein FtsW; Region: ftsW; TIGR02614
1117647009348	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1117647009349	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1117647009350	active site
1117647009351	homodimer interface [polypeptide binding]; other site
1117647009352	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1117647009353	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1117647009354	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1117647009355	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1117647009356	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
1117647009357	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1117647009358	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1117647009359	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1117647009360	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1117647009361	Cell division protein FtsQ; Region: FtsQ; pfam03799
1117647009362	cell division protein FtsA; Region: ftsA; TIGR01174
1117647009363	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1117647009364	nucleotide binding site [chemical binding]; other site
1117647009365	Cell division protein FtsA; Region: FtsA; pfam14450
1117647009366	cell division protein FtsZ; Validated; Region: PRK09330
1117647009367	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1117647009368	nucleotide binding site [chemical binding]; other site
1117647009369	SulA interaction site; other site
1117647009370	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1117647009371	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1117647009372	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1117647009373	Peptidase family M23; Region: Peptidase_M23; pfam01551
1117647009374	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1117647009375	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1117647009376	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1117647009377	SEC-C motif; Region: SEC-C; pfam02810
1117647009378	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1117647009379	heterotetramer interface [polypeptide binding]; other site
1117647009380	active site pocket [active]
1117647009381	cleavage site
1117647009382	Domain of unknown function (DUF329); Region: DUF329; pfam03884
1117647009383	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1117647009384	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1117647009385	CoA-binding site [chemical binding]; other site
1117647009386	ATP-binding [chemical binding]; other site
1117647009387	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1117647009388	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1117647009389	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1117647009390	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
1117647009391	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1117647009392	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1117647009393	Walker A motif; other site
1117647009394	ATP binding site [chemical binding]; other site
1117647009395	Walker B motif; other site
1117647009396	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
1117647009397	Pilin (bacterial filament); Region: Pilin; pfam00114
1117647009398	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117647009399	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1117647009400	NAD(P) binding site [chemical binding]; other site
1117647009401	active site
1117647009402	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1117647009403	FAD binding domain; Region: FAD_binding_4; pfam01565
1117647009404	GtrA-like protein; Region: GtrA; pfam04138
1117647009405	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
1117647009406	Divergent PAP2 family; Region: DUF212; pfam02681
1117647009407	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742
1117647009408	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1117647009409	dimerization interface [polypeptide binding]; other site
1117647009410	active site
1117647009411	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
1117647009412	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1117647009413	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1117647009414	amidase catalytic site [active]
1117647009415	Zn binding residues [ion binding]; other site
1117647009416	substrate binding site [chemical binding]; other site
1117647009417	Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896
1117647009418	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1117647009419	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1117647009420	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1117647009421	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1117647009422	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1117647009423	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
1117647009424	Walker A/P-loop; other site
1117647009425	ATP binding site [chemical binding]; other site
1117647009426	Q-loop/lid; other site
1117647009427	ABC transporter signature motif; other site
1117647009428	Walker B; other site
1117647009429	D-loop; other site
1117647009430	H-loop/switch region; other site
1117647009431	muropeptide transporter; Validated; Region: ampG; cl17669
1117647009432	muropeptide transporter; Validated; Region: ampG; cl17669
1117647009433	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1117647009434	DNA binding site [nucleotide binding]
1117647009435	active site
1117647009436	Protein of unknown function, DUF481; Region: DUF481; pfam04338
1117647009437	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
1117647009438	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1117647009439	oligomerisation interface [polypeptide binding]; other site
1117647009440	mobile loop; other site
1117647009441	roof hairpin; other site
1117647009442	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1117647009443	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1117647009444	ring oligomerisation interface [polypeptide binding]; other site
1117647009445	ATP/Mg binding site [chemical binding]; other site
1117647009446	stacking interactions; other site
1117647009447	hinge regions; other site
1117647009448	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
1117647009449	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1117647009450	nudix motif; other site
1117647009451	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
1117647009452	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
1117647009453	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
1117647009454	putative active site [active]
1117647009455	Zn binding site [ion binding]; other site
1117647009456	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1117647009457	dimer interface [polypeptide binding]; other site
1117647009458	Alkaline phosphatase homologues; Region: alkPPc; smart00098
1117647009459	active site
1117647009460	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647009461	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647009462	metal binding site [ion binding]; metal-binding site
1117647009463	active site
1117647009464	I-site; other site
1117647009465	Pirin-related protein [General function prediction only]; Region: COG1741
1117647009466	Pirin; Region: Pirin; pfam02678
1117647009467	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1117647009468	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1117647009469	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1117647009470	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
1117647009471	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117647009472	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1117647009473	dimerization interface [polypeptide binding]; other site
1117647009474	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
1117647009475	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1117647009476	Di-iron ligands [ion binding]; other site
1117647009477	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
1117647009478	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
1117647009479	heme-binding site [chemical binding]; other site
1117647009480	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
1117647009481	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
1117647009482	MOSC domain; Region: MOSC; pfam03473
1117647009483	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
1117647009484	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1117647009485	MPT binding site; other site
1117647009486	trimer interface [polypeptide binding]; other site
1117647009487	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
1117647009488	Walker A motif; other site
1117647009489	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
1117647009490	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
1117647009491	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
1117647009492	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1117647009493	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1117647009494	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1117647009495	ligand binding site [chemical binding]; other site
1117647009496	flexible hinge region; other site
1117647009497	4Fe-4S binding domain; Region: Fer4; pfam00037
1117647009498	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
1117647009499	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1117647009500	4Fe-4S binding domain; Region: Fer4; pfam00037
1117647009501	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1117647009502	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
1117647009503	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647009504	Walker A motif; other site
1117647009505	ATP binding site [chemical binding]; other site
1117647009506	Walker B motif; other site
1117647009507	arginine finger; other site
1117647009508	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1117647009509	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
1117647009510	hypothetical protein; Validated; Region: PRK00153
1117647009511	recombination protein RecR; Reviewed; Region: recR; PRK00076
1117647009512	RecR protein; Region: RecR; pfam02132
1117647009513	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1117647009514	putative active site [active]
1117647009515	putative metal-binding site [ion binding]; other site
1117647009516	tetramer interface [polypeptide binding]; other site
1117647009517	ribonuclease D; Region: rnd; TIGR01388
1117647009518	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1117647009519	catalytic site [active]
1117647009520	putative active site [active]
1117647009521	putative substrate binding site [chemical binding]; other site
1117647009522	HRDC domain; Region: HRDC; pfam00570
1117647009523	YcgL domain; Region: YcgL; pfam05166
1117647009524	hypothetical protein; Provisional; Region: PRK05170
1117647009525	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117647009526	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647009527	ATP binding site [chemical binding]; other site
1117647009528	Mg2+ binding site [ion binding]; other site
1117647009529	G-X-G motif; other site
1117647009530	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1117647009531	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647009532	active site
1117647009533	phosphorylation site [posttranslational modification]
1117647009534	intermolecular recognition site; other site
1117647009535	dimerization interface [polypeptide binding]; other site
1117647009536	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
1117647009537	DNA binding site [nucleotide binding]
1117647009538	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1117647009539	Domain of unknown function (DUF897); Region: DUF897; pfam05982
1117647009540	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1117647009541	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1117647009542	GTP binding site; other site
1117647009543	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
1117647009544	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1117647009545	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1117647009546	RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950
1117647009547	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117647009548	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1117647009549	DNA binding residues [nucleotide binding]
1117647009550	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1117647009551	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1117647009552	NAD(P) binding site [chemical binding]; other site
1117647009553	hypothetical protein; Provisional; Region: PRK05208
1117647009554	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1117647009555	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
1117647009556	dimer interface [polypeptide binding]; other site
1117647009557	putative metal binding site [ion binding]; other site
1117647009558	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1117647009559	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1117647009560	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
1117647009561	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
1117647009562	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1117647009563	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647009564	binding surface
1117647009565	TPR motif; other site
1117647009566	TPR repeat; Region: TPR_11; pfam13414
1117647009567	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117647009568	binding surface
1117647009569	TPR motif; other site
1117647009570	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1117647009571	Domain of unknown function (DUF4348); Region: DUF4348; pfam14254
1117647009572	Transposase; Region: HTH_Tnp_1; pfam01527
1117647009573	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1117647009574	HTH-like domain; Region: HTH_21; pfam13276
1117647009575	Integrase core domain; Region: rve; pfam00665
1117647009576	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1117647009577	Integrase core domain; Region: rve_3; cl15866
1117647009578	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
1117647009579	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
1117647009580	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1117647009581	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1117647009582	Flagellar protein YcgR; Region: YcgR_2; pfam12945
1117647009583	PilZ domain; Region: PilZ; pfam07238
1117647009584	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1117647009585	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1117647009586	active site
1117647009587	Zn binding site [ion binding]; other site
1117647009588	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1117647009589	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
1117647009590	active site
1117647009591	dimer interface [polypeptide binding]; other site
1117647009592	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
1117647009593	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
1117647009594	Helix-turn-helix domain; Region: HTH_18; pfam12833
1117647009595	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1117647009596	Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310
1117647009597	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
1117647009598	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647009599	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647009600	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
1117647009601	Cupin-like domain; Region: Cupin_8; pfam13621
1117647009602	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
1117647009603	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1117647009604	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1117647009605	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1117647009606	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
1117647009607	active site
1117647009608	catalytic residues [active]
1117647009609	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
1117647009610	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647009611	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647009612	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1117647009613	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1117647009614	ATP binding site [chemical binding]; other site
1117647009615	Mg++ binding site [ion binding]; other site
1117647009616	motif III; other site
1117647009617	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117647009618	ATP-binding site [chemical binding]; other site
1117647009619	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
1117647009620	putative RNA binding site [nucleotide binding]; other site
1117647009621	Transthyretin-like family; Region: DUF290; pfam01060
1117647009622	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1117647009623	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
1117647009624	DNA binding site [nucleotide binding]
1117647009625	AzlC protein; Region: AzlC; pfam03591
1117647009626	Predicted transcriptional regulators [Transcription]; Region: COG1510
1117647009627	MarR family; Region: MarR_2; pfam12802
1117647009628	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1117647009629	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1117647009630	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1117647009631	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1117647009632	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
1117647009633	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1117647009634	PYR/PP interface [polypeptide binding]; other site
1117647009635	dimer interface [polypeptide binding]; other site
1117647009636	TPP binding site [chemical binding]; other site
1117647009637	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1117647009638	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1117647009639	TPP-binding site [chemical binding]; other site
1117647009640	dimer interface [polypeptide binding]; other site
1117647009641	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1117647009642	metal ion-dependent adhesion site (MIDAS); other site
1117647009643	TIGR03503 family protein; Region: TIGR03503
1117647009644	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1117647009645	active site residue [active]
1117647009646	helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418
1117647009647	putative DNA binding site [nucleotide binding]; other site
1117647009648	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1117647009649	active site residue [active]
1117647009650	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
1117647009651	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1117647009652	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1117647009653	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1117647009654	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647009655	Walker A motif; other site
1117647009656	ATP binding site [chemical binding]; other site
1117647009657	Walker B motif; other site
1117647009658	arginine finger; other site
1117647009659	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
1117647009660	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
1117647009661	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117647009662	ATP binding site [chemical binding]; other site
1117647009663	putative Mg++ binding site [ion binding]; other site
1117647009664	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117647009665	nucleotide binding region [chemical binding]; other site
1117647009666	ATP-binding site [chemical binding]; other site
1117647009667	Helicase associated domain (HA2); Region: HA2; pfam04408
1117647009668	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
1117647009669	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
1117647009670	hypothetical protein; Provisional; Region: PRK05409
1117647009671	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
1117647009672	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1117647009673	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1117647009674	eyelet of channel; other site
1117647009675	trimer interface [polypeptide binding]; other site
1117647009676	VacJ like lipoprotein; Region: VacJ; cl01073
1117647009677	PilZ domain; Region: PilZ; pfam07238
1117647009678	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647009679	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647009680	active site
1117647009681	phosphorylation site [posttranslational modification]
1117647009682	intermolecular recognition site; other site
1117647009683	dimerization interface [polypeptide binding]; other site
1117647009684	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1117647009685	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1117647009686	anti sigma factor interaction site; other site
1117647009687	regulatory phosphorylation site [posttranslational modification]; other site
1117647009688	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
1117647009689	putative metal binding site [ion binding]; other site
1117647009690	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
1117647009691	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1117647009692	FMN binding site [chemical binding]; other site
1117647009693	active site
1117647009694	catalytic residues [active]
1117647009695	substrate binding site [chemical binding]; other site
1117647009696	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1117647009697	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117647009698	Coenzyme A binding pocket [chemical binding]; other site
1117647009699	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
1117647009700	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1117647009701	substrate binding site [chemical binding]; other site
1117647009702	oxyanion hole (OAH) forming residues; other site
1117647009703	trimer interface [polypeptide binding]; other site
1117647009704	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1117647009705	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1117647009706	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1117647009707	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
1117647009708	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1117647009709	dimer interface [polypeptide binding]; other site
1117647009710	active site
1117647009711	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
1117647009712	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1117647009713	ATP binding site [chemical binding]; other site
1117647009714	Walker B motif; other site
1117647009715	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
1117647009716	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
1117647009717	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647009718	putative substrate translocation pore; other site
1117647009719	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1117647009720	putative acyl-acceptor binding pocket; other site
1117647009721	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1117647009722	active site
1117647009723	CoA binding site [chemical binding]; other site
1117647009724	AMP binding site [chemical binding]; other site
1117647009725	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1117647009726	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1117647009727	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1117647009728	active site
1117647009729	Zn binding site [ion binding]; other site
1117647009730	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1117647009731	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1117647009732	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332
1117647009733	short chain dehydrogenase; Provisional; Region: PRK06181
1117647009734	NADP binding site [chemical binding]; other site
1117647009735	homodimer interface [polypeptide binding]; other site
1117647009736	substrate binding site [chemical binding]; other site
1117647009737	active site
1117647009738	hypothetical protein; Provisional; Region: PRK12378
1117647009739	elongation factor G; Reviewed; Region: PRK00007
1117647009740	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1117647009741	G1 box; other site
1117647009742	putative GEF interaction site [polypeptide binding]; other site
1117647009743	GTP/Mg2+ binding site [chemical binding]; other site
1117647009744	Switch I region; other site
1117647009745	G2 box; other site
1117647009746	G3 box; other site
1117647009747	Switch II region; other site
1117647009748	G4 box; other site
1117647009749	G5 box; other site
1117647009750	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1117647009751	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
1117647009752	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1117647009753	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1117647009754	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117647009755	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1117647009756	dimerization interface [polypeptide binding]; other site
1117647009757	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1117647009758	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117647009759	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1117647009760	dimerization interface [polypeptide binding]; other site
1117647009761	shikimate kinase; Reviewed; Region: aroK; PRK00131
1117647009762	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1117647009763	ADP binding site [chemical binding]; other site
1117647009764	magnesium binding site [ion binding]; other site
1117647009765	putative shikimate binding site; other site
1117647009766	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1117647009767	agmatinase; Region: agmatinase; TIGR01230
1117647009768	oligomer interface [polypeptide binding]; other site
1117647009769	putative active site [active]
1117647009770	Mn binding site [ion binding]; other site
1117647009771	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1117647009772	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1117647009773	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
1117647009774	NAD binding site [chemical binding]; other site
1117647009775	Phe binding site; other site
1117647009776	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1117647009777	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
1117647009778	putative active site [active]
1117647009779	putative FMN binding site [chemical binding]; other site
1117647009780	putative substrate binding site [chemical binding]; other site
1117647009781	putative catalytic residue [active]
1117647009782	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1117647009783	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117647009784	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1117647009785	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
1117647009786	putative metal binding site [ion binding]; other site
1117647009787	putative homodimer interface [polypeptide binding]; other site
1117647009788	putative homotetramer interface [polypeptide binding]; other site
1117647009789	putative homodimer-homodimer interface [polypeptide binding]; other site
1117647009790	putative allosteric switch controlling residues; other site
1117647009791	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1117647009792	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1117647009793	putative DNA binding site [nucleotide binding]; other site
1117647009794	putative Zn2+ binding site [ion binding]; other site
1117647009795	AsnC family; Region: AsnC_trans_reg; pfam01037
1117647009796	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1117647009797	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1117647009798	putative DNA binding site [nucleotide binding]; other site
1117647009799	putative Zn2+ binding site [ion binding]; other site
1117647009800	AsnC family; Region: AsnC_trans_reg; pfam01037
1117647009801	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1117647009802	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
1117647009803	NAD binding site [chemical binding]; other site
1117647009804	ligand binding site [chemical binding]; other site
1117647009805	catalytic site [active]
1117647009806	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117647009807	Coenzyme A binding pocket [chemical binding]; other site
1117647009808	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
1117647009809	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1117647009810	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
1117647009811	Glutamate binding site [chemical binding]; other site
1117647009812	NAD binding site [chemical binding]; other site
1117647009813	catalytic residues [active]
1117647009814	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
1117647009815	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1117647009816	putative DNA binding site [nucleotide binding]; other site
1117647009817	putative Zn2+ binding site [ion binding]; other site
1117647009818	AsnC family; Region: AsnC_trans_reg; pfam01037
1117647009819	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1117647009820	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1117647009821	active site
1117647009822	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1117647009823	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
1117647009824	NAD binding site [chemical binding]; other site
1117647009825	homodimer interface [polypeptide binding]; other site
1117647009826	homotetramer interface [polypeptide binding]; other site
1117647009827	active site
1117647009828	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647009829	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647009830	metal binding site [ion binding]; metal-binding site
1117647009831	active site
1117647009832	I-site; other site
1117647009833	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1117647009834	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1117647009835	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647009836	putative substrate translocation pore; other site
1117647009837	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1117647009838	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1117647009839	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
1117647009840	active site
1117647009841	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
1117647009842	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
1117647009843	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
1117647009844	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
1117647009845	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1117647009846	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1117647009847	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1117647009848	active site
1117647009849	catalytic tetrad [active]
1117647009850	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1117647009851	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1117647009852	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
1117647009853	putative C-terminal domain interface [polypeptide binding]; other site
1117647009854	putative GSH binding site (G-site) [chemical binding]; other site
1117647009855	putative dimer interface [polypeptide binding]; other site
1117647009856	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1117647009857	N-terminal domain interface [polypeptide binding]; other site
1117647009858	dimer interface [polypeptide binding]; other site
1117647009859	substrate binding pocket (H-site) [chemical binding]; other site
1117647009860	hypothetical protein; Provisional; Region: PRK10279
1117647009861	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1117647009862	active site
1117647009863	nucleophile elbow; other site
1117647009864	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1117647009865	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1117647009866	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1117647009867	HlyD family secretion protein; Region: HlyD_3; pfam13437
1117647009868	Predicted transcriptional regulators [Transcription]; Region: COG1695
1117647009869	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1117647009870	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
1117647009871	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1117647009872	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1117647009873	Walker A/P-loop; other site
1117647009874	ATP binding site [chemical binding]; other site
1117647009875	Q-loop/lid; other site
1117647009876	ABC transporter signature motif; other site
1117647009877	Walker B; other site
1117647009878	D-loop; other site
1117647009879	H-loop/switch region; other site
1117647009880	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1117647009881	DNA-binding site [nucleotide binding]; DNA binding site
1117647009882	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
1117647009883	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1117647009884	Protein of unknown function (DUF1761); Region: DUF1761; pfam08570
1117647009885	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117647009886	Coenzyme A binding pocket [chemical binding]; other site
1117647009887	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1117647009888	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1117647009889	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1117647009890	active site
1117647009891	Predicted membrane protein [Function unknown]; Region: COG2246
1117647009892	GtrA-like protein; Region: GtrA; pfam04138
1117647009893	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1117647009894	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1117647009895	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1117647009896	putative active site [active]
1117647009897	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1117647009898	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1117647009899	dimer interface [polypeptide binding]; other site
1117647009900	active site
1117647009901	metal binding site [ion binding]; metal-binding site
1117647009902	glutathione binding site [chemical binding]; other site
1117647009903	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1117647009904	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1117647009905	ligand binding site [chemical binding]; other site
1117647009906	flexible hinge region; other site
1117647009907	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1117647009908	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1117647009909	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1117647009910	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1117647009911	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1117647009912	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1117647009913	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
1117647009914	RES domain; Region: RES; smart00953
1117647009915	Predicted membrane protein [Function unknown]; Region: COG3671
1117647009916	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
1117647009917	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1117647009918	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1117647009919	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117647009920	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647009921	dimer interface [polypeptide binding]; other site
1117647009922	phosphorylation site [posttranslational modification]
1117647009923	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647009924	ATP binding site [chemical binding]; other site
1117647009925	Mg2+ binding site [ion binding]; other site
1117647009926	G-X-G motif; other site
1117647009927	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1117647009928	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647009929	active site
1117647009930	phosphorylation site [posttranslational modification]
1117647009931	intermolecular recognition site; other site
1117647009932	dimerization interface [polypeptide binding]; other site
1117647009933	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
1117647009934	putative binding surface; other site
1117647009935	active site
1117647009936	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
1117647009937	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1117647009938	N- and C-terminal domain interface [polypeptide binding]; other site
1117647009939	active site
1117647009940	MgATP binding site [chemical binding]; other site
1117647009941	catalytic site [active]
1117647009942	metal binding site [ion binding]; metal-binding site
1117647009943	glycerol binding site [chemical binding]; other site
1117647009944	homotetramer interface [polypeptide binding]; other site
1117647009945	homodimer interface [polypeptide binding]; other site
1117647009946	FBP binding site [chemical binding]; other site
1117647009947	protein IIAGlc interface [polypeptide binding]; other site
1117647009948	transaldolase-like protein; Provisional; Region: PTZ00411
1117647009949	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1117647009950	active site
1117647009951	dimer interface [polypeptide binding]; other site
1117647009952	catalytic residue [active]
1117647009953	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1117647009954	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
1117647009955	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
1117647009956	dimer interface [polypeptide binding]; other site
1117647009957	active site
1117647009958	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1117647009959	catalytic residues [active]
1117647009960	substrate binding site [chemical binding]; other site
1117647009961	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
1117647009962	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1117647009963	NAD(P) binding pocket [chemical binding]; other site
1117647009964	helicase 45; Provisional; Region: PTZ00424
1117647009965	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1117647009966	ATP binding site [chemical binding]; other site
1117647009967	Mg++ binding site [ion binding]; other site
1117647009968	motif III; other site
1117647009969	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117647009970	nucleotide binding region [chemical binding]; other site
1117647009971	ATP-binding site [chemical binding]; other site
1117647009972	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
1117647009973	translation initiation factor Sui1; Validated; Region: PRK06824
1117647009974	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
1117647009975	putative rRNA binding site [nucleotide binding]; other site
1117647009976	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
1117647009977	Ion transport protein; Region: Ion_trans; pfam00520
1117647009978	Ion channel; Region: Ion_trans_2; pfam07885
1117647009979	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1117647009980	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1117647009981	Beta-lactamase; Region: Beta-lactamase; pfam00144
1117647009982	SlyX; Region: SlyX; pfam04102
1117647009983	PAS domain; Region: PAS_9; pfam13426
1117647009984	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647009985	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647009986	metal binding site [ion binding]; metal-binding site
1117647009987	active site
1117647009988	I-site; other site
1117647009989	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1117647009990	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1117647009991	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117647009992	Coenzyme A binding pocket [chemical binding]; other site
1117647009993	Family description; Region: VCBS; pfam13517
1117647009994	Family description; Region: VCBS; pfam13517
1117647009995	Family description; Region: VCBS; pfam13517
1117647009996	Family description; Region: VCBS; pfam13517
1117647009997	Family description; Region: VCBS; pfam13517
1117647009998	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1117647009999	Sel1-like repeats; Region: SEL1; smart00671
1117647010000	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
1117647010001	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1117647010002	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1117647010003	active site
1117647010004	HIGH motif; other site
1117647010005	KMSK motif region; other site
1117647010006	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1117647010007	tRNA binding surface [nucleotide binding]; other site
1117647010008	anticodon binding site; other site
1117647010009	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1117647010010	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1117647010011	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
1117647010012	active site
1117647010013	Response regulator receiver domain; Region: Response_reg; pfam00072
1117647010014	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647010015	active site
1117647010016	phosphorylation site [posttranslational modification]
1117647010017	intermolecular recognition site; other site
1117647010018	dimerization interface [polypeptide binding]; other site
1117647010019	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
1117647010020	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1117647010021	PAS fold; Region: PAS_4; pfam08448
1117647010022	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1117647010023	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1117647010024	metal binding site [ion binding]; metal-binding site
1117647010025	active site
1117647010026	I-site; other site
1117647010027	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
1117647010028	active site
1117647010029	catalytic site [active]
1117647010030	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
1117647010031	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
1117647010032	vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461
1117647010033	metal ion-dependent adhesion site (MIDAS); other site
1117647010034	proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787
1117647010035	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117647010036	active site
1117647010037	phosphorylation site [posttranslational modification]
1117647010038	intermolecular recognition site; other site
1117647010039	dimerization interface [polypeptide binding]; other site
1117647010040	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1117647010041	DNA binding site [nucleotide binding]
1117647010042	proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785
1117647010043	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
1117647010044	putative ligand binding site [chemical binding]; other site
1117647010045	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117647010046	dimer interface [polypeptide binding]; other site
1117647010047	phosphorylation site [posttranslational modification]
1117647010048	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117647010049	ATP binding site [chemical binding]; other site
1117647010050	Mg2+ binding site [ion binding]; other site
1117647010051	G-X-G motif; other site
1117647010052	Protein of unknown function (DUF456); Region: DUF456; pfam04306
1117647010053	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1117647010054	ligand binding site [chemical binding]; other site
1117647010055	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
1117647010056	Zn binding site [ion binding]; other site
1117647010057	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1117647010058	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1117647010059	DNA-binding site [nucleotide binding]; DNA binding site
1117647010060	FCD domain; Region: FCD; pfam07729
1117647010061	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
1117647010062	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1117647010063	IHF dimer interface [polypeptide binding]; other site
1117647010064	IHF - DNA interface [nucleotide binding]; other site
1117647010065	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1117647010066	putative binding surface; other site
1117647010067	active site
1117647010068	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1117647010069	Zn2+ binding site [ion binding]; other site
1117647010070	Mg2+ binding site [ion binding]; other site
1117647010071	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
1117647010072	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1117647010073	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1117647010074	dimer interface [polypeptide binding]; other site
1117647010075	anticodon binding site; other site
1117647010076	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1117647010077	homodimer interface [polypeptide binding]; other site
1117647010078	motif 1; other site
1117647010079	active site
1117647010080	motif 2; other site
1117647010081	GAD domain; Region: GAD; pfam02938
1117647010082	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1117647010083	active site
1117647010084	motif 3; other site
1117647010085	hypothetical protein; Validated; Region: PRK00110
1117647010086	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1117647010087	active site
1117647010088	putative DNA-binding cleft [nucleotide binding]; other site
1117647010089	dimer interface [polypeptide binding]; other site
1117647010090	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1117647010091	RuvA N terminal domain; Region: RuvA_N; pfam01330
1117647010092	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1117647010093	helix-hairpin-helix signature motif; other site
1117647010094	active site
1117647010095	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1117647010096	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1117647010097	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117647010098	Walker A motif; other site
1117647010099	ATP binding site [chemical binding]; other site
1117647010100	Walker B motif; other site
1117647010101	arginine finger; other site
1117647010102	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1117647010103	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1117647010104	active site
1117647010105	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1117647010106	TolR protein; Region: tolR; TIGR02801
1117647010107	TolA protein; Region: tolA_full; TIGR02794
1117647010108	TonB C terminal; Region: TonB_2; pfam13103
1117647010109	translocation protein TolB; Provisional; Region: tolB; PRK00178
1117647010110	TolB amino-terminal domain; Region: TolB_N; pfam04052
1117647010111	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1117647010112	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1117647010113	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1117647010114	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
1117647010115	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1117647010116	ligand binding site [chemical binding]; other site
1117647010117	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1117647010118	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
1117647010119	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1117647010120	FeS/SAM binding site; other site
1117647010121	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1117647010122	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1117647010123	substrate binding pocket [chemical binding]; other site
1117647010124	membrane-bound complex binding site; other site
1117647010125	hinge residues; other site
1117647010126	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1117647010127	Ligand Binding Site [chemical binding]; other site
1117647010128	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
1117647010129	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1117647010130	beta-ketothiolase; Provisional; Region: PRK09051
1117647010131	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1117647010132	dimer interface [polypeptide binding]; other site
1117647010133	active site
1117647010134	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1117647010135	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1117647010136	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117647010137	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1117647010138	putative dimerization interface [polypeptide binding]; other site
1117647010139	malonyl-CoA synthase; Validated; Region: PRK07514
1117647010140	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
1117647010141	acyl-activating enzyme (AAE) consensus motif; other site
1117647010142	active site
1117647010143	AMP binding site [chemical binding]; other site
1117647010144	CoA binding site [chemical binding]; other site
1117647010145	succinic semialdehyde dehydrogenase; Region: PLN02278
1117647010146	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1117647010147	tetramerization interface [polypeptide binding]; other site
1117647010148	NAD(P) binding site [chemical binding]; other site
1117647010149	catalytic residues [active]
1117647010150	Modulator of Rho-dependent transcription termination (ROF); Region: ROF; pfam07073
1117647010151	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1117647010152	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1117647010153	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1117647010154	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1117647010155	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1117647010156	Ligand binding site; other site
1117647010157	metal-binding site
1117647010158	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1117647010159	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1117647010160	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1117647010161	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1117647010162	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1117647010163	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1117647010164	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1117647010165	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1117647010166	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
1117647010167	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1117647010168	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1117647010169	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1117647010170	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
1117647010171	dimer interface [polypeptide binding]; other site
1117647010172	NADP binding site [chemical binding]; other site
1117647010173	catalytic residues [active]
1117647010174	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1117647010175	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1117647010176	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
1117647010177	TrkA-N domain; Region: TrkA_N; pfam02254
1117647010178	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1117647010179	ThiS interaction site; other site
1117647010180	putative active site [active]
1117647010181	tetramer interface [polypeptide binding]; other site
1117647010182	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1117647010183	thiS-thiF/thiG interaction site; other site
1117647010184	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1117647010185	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1117647010186	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1117647010187	generic binding surface II; other site
1117647010188	generic binding surface I; other site
1117647010189	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1117647010190	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1117647010191	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1117647010192	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1117647010193	active site
1117647010194	GMP synthase; Reviewed; Region: guaA; PRK00074
1117647010195	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1117647010196	AMP/PPi binding site [chemical binding]; other site
1117647010197	candidate oxyanion hole; other site
1117647010198	catalytic triad [active]
1117647010199	potential glutamine specificity residues [chemical binding]; other site
1117647010200	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1117647010201	ATP Binding subdomain [chemical binding]; other site
1117647010202	Ligand Binding sites [chemical binding]; other site
1117647010203	Dimerization subdomain; other site
1117647010204	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1117647010205	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1117647010206	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1117647010207	active site
1117647010208	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668
1117647010209	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1117647010210	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
1117647010211	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1117647010212	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
1117647010213	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
1117647010214	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12504
1117647010215	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
1117647010216	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
1117647010217	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
1117647010218	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
1117647010219	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
1117647010220	lipase chaperone; Provisional; Region: PRK01294
1117647010221	Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224
1117647010222	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1117647010223	Lipase (class 2); Region: Lipase_2; pfam01674
1117647010224	PGAP1-like protein; Region: PGAP1; pfam07819
1117647010225	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1117647010226	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
1117647010227	tetramer interface [polypeptide binding]; other site
1117647010228	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117647010229	catalytic residue [active]
1117647010230	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1117647010231	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
1117647010232	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1117647010233	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
1117647010234	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1117647010235	N-terminal plug; other site
1117647010236	ligand-binding site [chemical binding]; other site
1117647010237	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1117647010238	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1117647010239	phosphopeptide binding site; other site
1117647010240	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1117647010241	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1117647010242	active site
1117647010243	ATP binding site [chemical binding]; other site
1117647010244	substrate binding site [chemical binding]; other site
1117647010245	activation loop (A-loop); other site
1117647010246	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1117647010247	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1117647010248	phosphopeptide binding site; other site
1117647010249	Ferredoxin [Energy production and conversion]; Region: COG1146
1117647010250	4Fe-4S binding domain; Region: Fer4; cl02805
1117647010251	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
1117647010252	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1117647010253	MutS domain I; Region: MutS_I; pfam01624
1117647010254	MutS domain II; Region: MutS_II; pfam05188
1117647010255	MutS domain III; Region: MutS_III; pfam05192
1117647010256	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1117647010257	Walker A/P-loop; other site
1117647010258	ATP binding site [chemical binding]; other site
1117647010259	Q-loop/lid; other site
1117647010260	ABC transporter signature motif; other site
1117647010261	Walker B; other site
1117647010262	D-loop; other site
1117647010263	H-loop/switch region; other site
1117647010264	Competence-damaged protein; Region: CinA; cl00666
1117647010265	recombinase A; Provisional; Region: recA; PRK09354
1117647010266	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1117647010267	hexamer interface [polypeptide binding]; other site
1117647010268	Walker A motif; other site
1117647010269	ATP binding site [chemical binding]; other site
1117647010270	Walker B motif; other site
1117647010271	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
1117647010272	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1117647010273	Protein phosphatase 2C; Region: PP2C; pfam00481
1117647010274	active site
1117647010275	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
1117647010276	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1117647010277	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
1117647010278	active site
1117647010279	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1117647010280	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1117647010281	active site
1117647010282	dimer interface [polypeptide binding]; other site
1117647010283	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1117647010284	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1117647010285	dimer interface [polypeptide binding]; other site
1117647010286	active site
1117647010287	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1117647010288	dimer interface [polypeptide binding]; other site
1117647010289	active site
1117647010290	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1117647010291	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1117647010292	DNA binding site [nucleotide binding]
1117647010293	domain linker motif; other site
1117647010294	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
1117647010295	putative dimerization interface [polypeptide binding]; other site
1117647010296	putative ligand binding site [chemical binding]; other site
1117647010297	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1117647010298	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1117647010299	active site
1117647010300	dimer interface [polypeptide binding]; other site
1117647010301	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1117647010302	dimer interface [polypeptide binding]; other site
1117647010303	active site
1117647010304	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
1117647010305	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1117647010306	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1117647010307	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1117647010308	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1117647010309	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
1117647010310	active site
1117647010311	dimer interfaces [polypeptide binding]; other site
1117647010312	catalytic residues [active]
1117647010313	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1117647010314	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117647010315	putative substrate translocation pore; other site
1117647010316	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1117647010317	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1117647010318	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1117647010319	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1117647010320	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1117647010321	putative active site [active]
1117647010322	phosphogluconate dehydratase; Validated; Region: PRK09054
1117647010323	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1117647010324	glucokinase, proteobacterial type; Region: glk; TIGR00749
1117647010325	Glucokinase; Region: Glucokinase; pfam02685
1117647010326	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1117647010327	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
1117647010328	active site
1117647010329	intersubunit interface [polypeptide binding]; other site
1117647010330	catalytic residue [active]
1117647010331	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1117647010332	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1117647010333	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1117647010334	pyruvate kinase; Provisional; Region: PRK05826
1117647010335	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1117647010336	domain interfaces; other site
1117647010337	active site
1117647010338	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1117647010339	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1117647010340	DNA binding site [nucleotide binding]
1117647010341	domain linker motif; other site
1117647010342	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
1117647010343	putative dimerization interface [polypeptide binding]; other site
1117647010344	putative ligand binding site [chemical binding]; other site
1117647010345	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1117647010346	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1117647010347	HlyD family secretion protein; Region: HlyD_3; pfam13437
1117647010348	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844