-- dump date   	20140620_065750
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
331113000001	ABC transporter ATPase component; Reviewed; Region: PRK11147
331113000002	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
331113000003	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
331113000004	active site
331113000005	substrate binding site [chemical binding]; other site
331113000006	Mg2+ binding site [ion binding]; other site
331113000007	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113000008	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113000009	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113000010	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113000011	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
331113000012	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331113000013	non-specific DNA binding site [nucleotide binding]; other site
331113000014	salt bridge; other site
331113000015	sequence-specific DNA binding site [nucleotide binding]; other site
331113000016	RecT family; Region: RecT; cl04285
331113000017	GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541
331113000018	active site
331113000019	GIY-YIG motif/motif A; other site
331113000020	catalytic site [active]
331113000021	A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411
331113000022	Uncharacterized protein conserved in bacteria (DUF2251); Region: DUF2251; pfam10008
331113000023	Domain of unknown function (DUF4135); Region: DUF4135; pfam13575
331113000024	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
331113000025	DNA binding site [nucleotide binding]
331113000026	AAA domain; Region: AAA_22; pfam13401
331113000027	AAA domain; Region: AAA_14; pfam13173
331113000028	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
331113000029	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
331113000030	active site
331113000031	catalytic residues [active]
331113000032	DNA binding site [nucleotide binding]
331113000033	Int/Topo IB signature motif; other site
331113000034	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
331113000035	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
331113000036	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
331113000037	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
331113000038	multiple promoter invertase; Provisional; Region: mpi; PRK13413
331113000039	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
331113000040	catalytic residues [active]
331113000041	catalytic nucleophile [active]
331113000042	Presynaptic Site I dimer interface [polypeptide binding]; other site
331113000043	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
331113000044	Synaptic Flat tetramer interface [polypeptide binding]; other site
331113000045	Synaptic Site I dimer interface [polypeptide binding]; other site
331113000046	DNA binding site [nucleotide binding]
331113000047	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
331113000048	DNA-binding interface [nucleotide binding]; DNA binding site
331113000049	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
331113000050	linker region; other site
331113000051	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
331113000052	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
331113000053	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
331113000054	putative active site [active]
331113000055	putative NTP binding site [chemical binding]; other site
331113000056	putative nucleic acid binding site [nucleotide binding]; other site
331113000057	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
331113000058	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
331113000059	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
331113000060	MobA/MobL family; Region: MobA_MobL; pfam03389
331113000061	AAA domain; Region: AAA_30; pfam13604
331113000062	DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358
331113000063	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
331113000064	active site
331113000065	metal binding site [ion binding]; metal-binding site
331113000066	interdomain interaction site; other site
331113000067	SWI complex, BAF60b domains; Region: SWIB; smart00151
331113000068	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
331113000069	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
331113000070	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
331113000071	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
331113000072	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
331113000073	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
331113000074	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
331113000075	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
331113000076	Outer membrane efflux protein; Region: OEP; pfam02321
331113000077	Outer membrane efflux protein; Region: OEP; pfam02321
331113000078	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
331113000079	HlyD family secretion protein; Region: HlyD_3; pfam13437
331113000080	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
331113000081	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
331113000082	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
331113000083	mercuric reductase; Region: MerA; TIGR02053
331113000084	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331113000085	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331113000086	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
331113000087	alkylmercury lyase; Provisional; Region: PRK13239
331113000088	Alkylmercury lyase; Region: MerB; pfam03243
331113000089	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
331113000090	DNA binding residues [nucleotide binding]
331113000091	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
331113000092	Methyltransferase domain; Region: Methyltransf_31; pfam13847
331113000093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113000094	S-adenosylmethionine binding site [chemical binding]; other site
331113000095	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
331113000096	Outer membrane efflux protein; Region: OEP; pfam02321
331113000097	Outer membrane efflux protein; Region: OEP; pfam02321
331113000098	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
331113000099	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
331113000100	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
331113000101	multiple promoter invertase; Provisional; Region: mpi; PRK13413
331113000102	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
331113000103	catalytic residues [active]
331113000104	catalytic nucleophile [active]
331113000105	Presynaptic Site I dimer interface [polypeptide binding]; other site
331113000106	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
331113000107	Synaptic Flat tetramer interface [polypeptide binding]; other site
331113000108	Synaptic Site I dimer interface [polypeptide binding]; other site
331113000109	DNA binding site [nucleotide binding]
331113000110	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
331113000111	DNA-binding interface [nucleotide binding]; DNA binding site
331113000112	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
331113000113	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
331113000114	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
331113000115	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
331113000116	multiple promoter invertase; Provisional; Region: mpi; PRK13413
331113000117	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
331113000118	catalytic residues [active]
331113000119	catalytic nucleophile [active]
331113000120	Presynaptic Site I dimer interface [polypeptide binding]; other site
331113000121	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
331113000122	Synaptic Flat tetramer interface [polypeptide binding]; other site
331113000123	Synaptic Site I dimer interface [polypeptide binding]; other site
331113000124	DNA binding site [nucleotide binding]
331113000125	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
331113000126	DNA-binding interface [nucleotide binding]; DNA binding site
331113000127	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
331113000128	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
331113000129	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
331113000130	Walker A motif; other site
331113000131	ATP binding site [chemical binding]; other site
331113000132	Walker B motif; other site
331113000133	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331113000134	non-specific DNA binding site [nucleotide binding]; other site
331113000135	salt bridge; other site
331113000136	sequence-specific DNA binding site [nucleotide binding]; other site
331113000137	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
331113000138	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
331113000139	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
331113000140	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
331113000141	Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580
331113000142	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
331113000143	Type-1V conjugative transfer system mating pair stabilisation; Region: TraN; pfam06986
331113000144	TraU protein; Region: TraU; pfam06834
331113000145	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883
331113000146	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
331113000147	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
331113000148	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
331113000149	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
331113000150	Walker A motif; other site
331113000151	ATP binding site [chemical binding]; other site
331113000152	Thioredoxin; Region: Thioredoxin_4; cl17273
331113000153	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
331113000154	conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878
331113000155	TraE protein; Region: TraE; cl05060
331113000156	TraL protein; Region: TraL; cl06278
331113000157	putative metal dependent hydrolase; Provisional; Region: PRK11598
331113000158	Poxvirus G7-like; Region: Pox_G7; cl17826
331113000159	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
331113000160	IHF - DNA interface [nucleotide binding]; other site
331113000161	IHF dimer interface [polypeptide binding]; other site
331113000162	Probable transposase; Region: OrfB_IS605; pfam01385
331113000163	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
331113000164	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
331113000165	Methyltransferase domain; Region: Methyltransf_23; pfam13489
331113000166	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113000167	S-adenosylmethionine binding site [chemical binding]; other site
331113000168	replicative DNA helicase; Region: DnaB; TIGR00665
331113000169	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
331113000170	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
331113000171	Walker A motif; other site
331113000172	ATP binding site [chemical binding]; other site
331113000173	Walker B motif; other site
331113000174	DNA binding loops [nucleotide binding]
331113000175	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
331113000176	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
331113000177	Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677
331113000178	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
331113000179	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
331113000180	Methyltransferase domain; Region: Methyltransf_31; pfam13847
331113000181	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113000182	S-adenosylmethionine binding site [chemical binding]; other site
331113000183	putative pectinesterase; Region: PLN02432; cl01911
331113000184	short chain dehydrogenase; Provisional; Region: PRK08219
331113000185	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331113000186	NAD(P) binding site [chemical binding]; other site
331113000187	active site
331113000188	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
331113000189	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
331113000190	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331113000191	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
331113000192	homodimer interface [polypeptide binding]; other site
331113000193	chemical substrate binding site [chemical binding]; other site
331113000194	oligomer interface [polypeptide binding]; other site
331113000195	metal binding site [ion binding]; metal-binding site
331113000196	TPR repeat; Region: TPR_11; pfam13414
331113000197	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331113000198	binding surface
331113000199	TPR motif; other site
331113000200	Methyltransferase domain; Region: Methyltransf_31; pfam13847
331113000201	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113000202	S-adenosylmethionine binding site [chemical binding]; other site
331113000203	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
331113000204	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
331113000205	acyl-activating enzyme (AAE) consensus motif; other site
331113000206	AMP binding site [chemical binding]; other site
331113000207	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
331113000208	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
331113000209	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
331113000210	active site
331113000211	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331113000212	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
331113000213	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
331113000214	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
331113000215	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
331113000216	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
331113000217	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
331113000218	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
331113000219	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
331113000220	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331113000221	non-specific DNA binding site [nucleotide binding]; other site
331113000222	salt bridge; other site
331113000223	sequence-specific DNA binding site [nucleotide binding]; other site
331113000224	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
331113000225	active site
331113000226	ATP binding site [chemical binding]; other site
331113000227	substrate binding site [chemical binding]; other site
331113000228	activation loop (A-loop); other site
331113000229	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
331113000230	Part of AAA domain; Region: AAA_19; pfam13245
331113000231	Family description; Region: UvrD_C_2; pfam13538
331113000232	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
331113000233	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
331113000234	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
331113000235	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
331113000236	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
331113000237	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113000238	D-galactonate transporter; Region: 2A0114; TIGR00893
331113000239	putative substrate translocation pore; other site
331113000240	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
331113000241	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298
331113000242	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
331113000243	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
331113000244	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
331113000245	Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774
331113000246	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
331113000247	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
331113000248	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
331113000249	active site
331113000250	nucleophile elbow; other site
331113000251	Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308
331113000252	Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308
331113000253	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
331113000254	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
331113000255	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
331113000256	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
331113000257	active site
331113000258	dimer interface [polypeptide binding]; other site
331113000259	motif 1; other site
331113000260	motif 2; other site
331113000261	motif 3; other site
331113000262	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
331113000263	anticodon binding site; other site
331113000264	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
331113000265	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
331113000266	Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677
331113000267	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
331113000268	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
331113000269	tetramer interface [polypeptide binding]; other site
331113000270	active site
331113000271	Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407
331113000272	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113000273	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113000274	putative substrate translocation pore; other site
331113000275	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
331113000276	active site
331113000277	metal binding site [ion binding]; metal-binding site
331113000278	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
331113000279	RNA binding site [nucleotide binding]; other site
331113000280	Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847
331113000281	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113000282	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113000283	putative substrate translocation pore; other site
331113000284	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
331113000285	ligand binding site [chemical binding]; other site
331113000286	active site
331113000287	UGI interface [polypeptide binding]; other site
331113000288	catalytic site [active]
331113000289	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113000290	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113000291	Autotransporter beta-domain; Region: Autotransporter; pfam03797
331113000292	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
331113000293	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
331113000294	DNA methylase; Region: N6_N4_Mtase; cl17433
331113000295	Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636
331113000296	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
331113000297	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
331113000298	substrate binding pocket [chemical binding]; other site
331113000299	chain length determination region; other site
331113000300	substrate-Mg2+ binding site; other site
331113000301	catalytic residues [active]
331113000302	aspartate-rich region 1; other site
331113000303	active site lid residues [active]
331113000304	aspartate-rich region 2; other site
331113000305	recombinase A; Provisional; Region: recA; PRK09354
331113000306	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
331113000307	hexamer interface [polypeptide binding]; other site
331113000308	Walker A motif; other site
331113000309	ATP binding site [chemical binding]; other site
331113000310	Walker B motif; other site
331113000311	Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: LeuS; COG0495
331113000312	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
331113000313	glucokinase, proteobacterial type; Region: glk; TIGR00749
331113000314	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
331113000315	nucleotide binding site [chemical binding]; other site
331113000316	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
331113000317	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
331113000318	RHS Repeat; Region: RHS_repeat; pfam05593
331113000319	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
331113000320	RHS Repeat; Region: RHS_repeat; pfam05593
331113000321	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
331113000322	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
331113000323	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
331113000324	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG1665
331113000325	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
331113000326	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331113000327	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331113000328	homodimer interface [polypeptide binding]; other site
331113000329	catalytic residue [active]
331113000330	rod shape-determining protein MreC; Provisional; Region: PRK14872
331113000331	rod shape-determining protein MreC; Region: MreC; pfam04085
331113000332	rod shape-determining protein MreC; Region: MreC; pfam04085
331113000333	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
331113000334	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
331113000335	Walker A/P-loop; other site
331113000336	ATP binding site [chemical binding]; other site
331113000337	Q-loop/lid; other site
331113000338	ABC transporter signature motif; other site
331113000339	Walker B; other site
331113000340	D-loop; other site
331113000341	H-loop/switch region; other site
331113000342	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331113000343	dimer interface [polypeptide binding]; other site
331113000344	conserved gate region; other site
331113000345	ABC-ATPase subunit interface; other site
331113000346	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
331113000347	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
331113000348	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
331113000349	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
331113000350	minor groove reading motif; other site
331113000351	helix-hairpin-helix signature motif; other site
331113000352	substrate binding pocket [chemical binding]; other site
331113000353	active site
331113000354	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
331113000355	DNA binding and oxoG recognition site [nucleotide binding]
331113000356	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
331113000357	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
331113000358	metal-binding site [ion binding]
331113000359	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
331113000360	Soluble P-type ATPase [General function prediction only]; Region: COG4087
331113000361	Protein of unknown function (DUF964); Region: DUF964; cl01483
331113000362	type II secretion system protein D; Region: type_II_gspD; TIGR02517
331113000363	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
331113000364	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
331113000365	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
331113000366	type II secretion system protein E; Region: type_II_gspE; TIGR02533
331113000367	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
331113000368	Walker A motif; other site
331113000369	ATP binding site [chemical binding]; other site
331113000370	Walker B motif; other site
331113000371	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
331113000372	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
331113000373	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
331113000374	Rhomboid family; Region: Rhomboid; pfam01694
331113000375	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
331113000376	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
331113000377	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
331113000378	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
331113000379	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
331113000380	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113000381	S-adenosylmethionine binding site [chemical binding]; other site
331113000382	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
331113000383	metal ion-dependent adhesion site (MIDAS); other site
331113000384	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
331113000385	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
331113000386	Protein-tyrosine phosphatase; Region: Y_phosphatase; pfam00102
331113000387	active site
331113000388	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
331113000389	active site
331113000390	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
331113000391	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331113000392	active site
331113000393	Tetratricopeptide repeat; Region: TPR_12; pfam13424
331113000394	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331113000395	TPR motif; other site
331113000396	binding surface
331113000397	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113000398	putative substrate translocation pore; other site
331113000399	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113000400	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331113000401	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331113000402	active site
331113000403	phosphorylation site [posttranslational modification]
331113000404	intermolecular recognition site; other site
331113000405	dimerization interface [polypeptide binding]; other site
331113000406	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331113000407	DNA binding site [nucleotide binding]
331113000408	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
331113000409	ADP-ribose binding site [chemical binding]; other site
331113000410	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
331113000411	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
331113000412	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
331113000413	ligand binding site [chemical binding]; other site
331113000414	translocation protein TolB; Provisional; Region: tolB; PRK01029
331113000415	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
331113000416	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
331113000417	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
331113000418	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
331113000419	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
331113000420	active site
331113000421	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
331113000422	putative Iron-sulfur protein interface [polypeptide binding]; other site
331113000423	proximal heme binding site [chemical binding]; other site
331113000424	putative dimer interface [polypeptide binding]; other site
331113000425	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
331113000426	proximal heme binding site [chemical binding]; other site
331113000427	Iron-sulfur protein interface; other site
331113000428	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
331113000429	L-aspartate oxidase; Provisional; Region: PRK06175
331113000430	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
331113000431	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
331113000432	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
331113000433	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
331113000434	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
331113000435	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
331113000436	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
331113000437	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331113000438	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
331113000439	NAD(P) binding site [chemical binding]; other site
331113000440	active site
331113000441	Methyltransferase domain; Region: Methyltransf_31; pfam13847
331113000442	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113000443	S-adenosylmethionine binding site [chemical binding]; other site
331113000444	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
331113000445	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
331113000446	Substrate binding site; other site
331113000447	Cupin domain; Region: Cupin_2; cl17218
331113000448	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
331113000449	Response regulator receiver domain; Region: Response_reg; pfam00072
331113000450	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331113000451	active site
331113000452	phosphorylation site [posttranslational modification]
331113000453	intermolecular recognition site; other site
331113000454	dimerization interface [polypeptide binding]; other site
331113000455	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
331113000456	active site
331113000457	I-site; other site
331113000458	metal binding site [ion binding]; metal-binding site
331113000459	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
331113000460	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
331113000461	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
331113000462	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
331113000463	replicative DNA helicase; Provisional; Region: PRK06321
331113000464	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
331113000465	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
331113000466	Walker A motif; other site
331113000467	ATP binding site [chemical binding]; other site
331113000468	Walker B motif; other site
331113000469	DNA binding loops [nucleotide binding]
331113000470	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
331113000471	dimer interface [polypeptide binding]; other site
331113000472	ADP-ribose binding site [chemical binding]; other site
331113000473	active site
331113000474	nudix motif; other site
331113000475	metal binding site [ion binding]; metal-binding site
331113000476	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
331113000477	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
331113000478	active site
331113000479	Zn binding site [ion binding]; other site
331113000480	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
331113000481	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331113000482	ATP binding site [chemical binding]; other site
331113000483	Mg2+ binding site [ion binding]; other site
331113000484	G-X-G motif; other site
331113000485	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
331113000486	ATP binding site [chemical binding]; other site
331113000487	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
331113000488	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
331113000489	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
331113000490	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
331113000491	active site
331113000492	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331113000493	dimerization interface [polypeptide binding]; other site
331113000494	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
331113000495	cyclase homology domain; Region: CHD; cd07302
331113000496	nucleotidyl binding site; other site
331113000497	metal binding site [ion binding]; metal-binding site
331113000498	dimer interface [polypeptide binding]; other site
331113000499	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
331113000500	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
331113000501	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331113000502	sequence-specific DNA binding site [nucleotide binding]; other site
331113000503	salt bridge; other site
331113000504	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
331113000505	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
331113000506	putative active site [active]
331113000507	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331113000508	dimer interface [polypeptide binding]; other site
331113000509	phosphorylation site [posttranslational modification]
331113000510	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331113000511	ATP binding site [chemical binding]; other site
331113000512	G-X-G motif; other site
331113000513	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
331113000514	Prokaryotic N-terminal methylation site; Region: N_methyl_3; pfam13633
331113000515	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
331113000516	DDE superfamily endonuclease; Region: DDE_3; pfam13358
331113000517	OPT oligopeptide transporter protein; Region: OPT; cl14607
331113000518	OPT oligopeptide transporter protein; Region: OPT; cl14607
331113000519	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
331113000520	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
331113000521	active site
331113000522	metal binding site [ion binding]; metal-binding site
331113000523	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
331113000524	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
331113000525	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
331113000526	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
331113000527	ligand binding site; other site
331113000528	oligomer interface; other site
331113000529	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
331113000530	dimer interface [polypeptide binding]; other site
331113000531	N-terminal domain interface [polypeptide binding]; other site
331113000532	sulfate 1 binding site; other site
331113000533	HEAT repeats; Region: HEAT_2; pfam13646
331113000534	lipoyl synthase; Provisional; Region: PRK05481
331113000535	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331113000536	FeS/SAM binding site; other site
331113000537	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
331113000538	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
331113000539	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331113000540	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
331113000541	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
331113000542	Protein of unknown function, DUF547; Region: DUF547; pfam04784
331113000543	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
331113000544	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899
331113000545	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
331113000546	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
331113000547	nucleotide binding region [chemical binding]; other site
331113000548	ATP-binding site [chemical binding]; other site
331113000549	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
331113000550	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
331113000551	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
331113000552	putative NAD(P) binding site [chemical binding]; other site
331113000553	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
331113000554	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
331113000555	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
331113000556	minor groove reading motif; other site
331113000557	helix-hairpin-helix signature motif; other site
331113000558	substrate binding pocket [chemical binding]; other site
331113000559	active site
331113000560	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
331113000561	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
331113000562	trmE is a tRNA modification GTPase; Region: trmE; cd04164
331113000563	G1 box; other site
331113000564	GTP/Mg2+ binding site [chemical binding]; other site
331113000565	Switch I region; other site
331113000566	G2 box; other site
331113000567	Switch II region; other site
331113000568	G3 box; other site
331113000569	G4 box; other site
331113000570	G5 box; other site
331113000571	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
331113000572	Chorismate mutase type II; Region: CM_2; smart00830
331113000573	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
331113000574	RuvA N terminal domain; Region: RuvA_N; pfam01330
331113000575	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
331113000576	DNA binding site [nucleotide binding]
331113000577	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
331113000578	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
331113000579	active site
331113000580	putative DNA-binding cleft [nucleotide binding]; other site
331113000581	dimer interface [polypeptide binding]; other site
331113000582	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
331113000583	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
331113000584	putative active site [active]
331113000585	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
331113000586	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
331113000587	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331113000588	active site
331113000589	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
331113000590	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113000591	Walker A motif; other site
331113000592	ATP binding site [chemical binding]; other site
331113000593	Walker B motif; other site
331113000594	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
331113000595	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
331113000596	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
331113000597	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
331113000598	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
331113000599	putative substrate binding site [chemical binding]; other site
331113000600	putative ATP binding site [chemical binding]; other site
331113000601	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
331113000602	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
331113000603	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331113000604	Walker A/P-loop; other site
331113000605	ATP binding site [chemical binding]; other site
331113000606	Q-loop/lid; other site
331113000607	ABC transporter signature motif; other site
331113000608	Walker B; other site
331113000609	D-loop; other site
331113000610	H-loop/switch region; other site
331113000611	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
331113000612	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
331113000613	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
331113000614	putative NAD(P) binding site [chemical binding]; other site
331113000615	active site
331113000616	putative substrate binding site [chemical binding]; other site
331113000617	polysaccharide export protein Wza; Provisional; Region: PRK15078
331113000618	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
331113000619	SLBB domain; Region: SLBB; pfam10531
331113000620	AAA domain; Region: AAA_31; pfam13614
331113000621	O-Antigen ligase; Region: Wzy_C; pfam04932
331113000622	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
331113000623	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
331113000624	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
331113000625	rRNA interaction site [nucleotide binding]; other site
331113000626	S8 interaction site; other site
331113000627	putative laminin-1 binding site; other site
331113000628	elongation factor Ts; Provisional; Region: tsf; PRK09377
331113000629	UBA/TS-N domain; Region: UBA; pfam00627
331113000630	Elongation factor TS; Region: EF_TS; pfam00889
331113000631	Elongation factor TS; Region: EF_TS; pfam00889
331113000632	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
331113000633	putative nucleotide binding site [chemical binding]; other site
331113000634	uridine monophosphate binding site [chemical binding]; other site
331113000635	homohexameric interface [polypeptide binding]; other site
331113000636	ribosome recycling factor; Reviewed; Region: frr; PRK00083
331113000637	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
331113000638	hinge region; other site
331113000639	Fic/DOC family; Region: Fic; pfam02661
331113000640	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
331113000641	catalytic core [active]
331113000642	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
331113000643	putative dimer interface [polypeptide binding]; other site
331113000644	catalytic triad [active]
331113000645	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
331113000646	substrate binding site; other site
331113000647	dimer interface; other site
331113000648	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
331113000649	classical (c) SDRs; Region: SDR_c; cd05233
331113000650	NAD(P) binding site [chemical binding]; other site
331113000651	active site
331113000652	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
331113000653	Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823
331113000654	ADP binding site [chemical binding]; other site
331113000655	phosphagen binding site; other site
331113000656	substrate specificity loop; other site
331113000657	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
331113000658	UvrB/uvrC motif; Region: UVR; pfam02151
331113000659	CAAX protease self-immunity; Region: Abi; pfam02517
331113000660	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
331113000661	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
331113000662	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
331113000663	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
331113000664	tetramerization interface [polypeptide binding]; other site
331113000665	NAD(P) binding site [chemical binding]; other site
331113000666	catalytic residues [active]
331113000667	Archaeal ATPase; Region: Arch_ATPase; pfam01637
331113000668	AAA domain; Region: AAA_14; pfam13173
331113000669	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
331113000670	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
331113000671	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
331113000672	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
331113000673	NADP binding site [chemical binding]; other site
331113000674	active site
331113000675	putative substrate binding site [chemical binding]; other site
331113000676	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
331113000677	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
331113000678	NAD binding site [chemical binding]; other site
331113000679	substrate binding site [chemical binding]; other site
331113000680	homodimer interface [polypeptide binding]; other site
331113000681	active site
331113000682	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
331113000683	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
331113000684	Ligand binding site; other site
331113000685	oligomer interface; other site
331113000686	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
331113000687	putative ABC transporter; Region: ycf24; CHL00085
331113000688	FeS assembly ATPase SufC; Region: sufC; TIGR01978
331113000689	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
331113000690	Walker A/P-loop; other site
331113000691	ATP binding site [chemical binding]; other site
331113000692	Q-loop/lid; other site
331113000693	ABC transporter signature motif; other site
331113000694	Walker B; other site
331113000695	D-loop; other site
331113000696	H-loop/switch region; other site
331113000697	FeS assembly protein SufD; Region: sufD; TIGR01981
331113000698	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
331113000699	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
331113000700	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
331113000701	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331113000702	catalytic residue [active]
331113000703	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113000704	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113000705	Autotransporter beta-domain; Region: Autotransporter; cl17461
331113000706	Autotransporter beta-domain; Region: Autotransporter; smart00869
331113000707	Autotransporter beta-domain; Region: Autotransporter; cl17461
331113000708	Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791
331113000709	Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794
331113000710	FliP family; Region: FliP; cl00593
331113000711	type III secretion system protein; Validated; Region: PRK06328
331113000712	Flagellar assembly protein FliH; Region: FliH; pfam02108
331113000713	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
331113000714	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
331113000715	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
331113000716	Probable Catalytic site; other site
331113000717	metal-binding site
331113000718	exopolyphosphatase; Region: exo_poly_only; TIGR03706
331113000719	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
331113000720	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
331113000721	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
331113000722	putative active site [active]
331113000723	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
331113000724	Heavy-metal-associated domain; Region: HMA; pfam00403
331113000725	metal-binding site [ion binding]
331113000726	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
331113000727	Soluble P-type ATPase [General function prediction only]; Region: COG4087
331113000728	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
331113000729	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331113000730	substrate binding pocket [chemical binding]; other site
331113000731	membrane-bound complex binding site; other site
331113000732	hinge residues; other site
331113000733	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
331113000734	homodimer interface [polypeptide binding]; other site
331113000735	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
331113000736	active site pocket [active]
331113000737	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
331113000738	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
331113000739	Protein of unknown function DUF47; Region: PhoU_div; pfam01865
331113000740	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
331113000741	RNA binding surface [nucleotide binding]; other site
331113000742	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
331113000743	pseudouridine synthase; Region: TIGR00093
331113000744	active site
331113000745	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
331113000746	catalytic core [active]
331113000747	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
331113000748	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
331113000749	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331113000750	catalytic residue [active]
331113000751	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
331113000752	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
331113000753	active site
331113000754	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
331113000755	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331113000756	dimerization interface [polypeptide binding]; other site
331113000757	putative DNA binding site [nucleotide binding]; other site
331113000758	putative Zn2+ binding site [ion binding]; other site
331113000759	BioY family; Region: BioY; pfam02632
331113000760	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
331113000761	conserved cys residue [active]
331113000762	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
331113000763	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
331113000764	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
331113000765	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
331113000766	Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978
331113000767	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
331113000768	elongation factor G; Reviewed; Region: PRK12739
331113000769	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
331113000770	G1 box; other site
331113000771	putative GEF interaction site [polypeptide binding]; other site
331113000772	GTP/Mg2+ binding site [chemical binding]; other site
331113000773	Switch I region; other site
331113000774	G2 box; other site
331113000775	G3 box; other site
331113000776	Switch II region; other site
331113000777	G4 box; other site
331113000778	G5 box; other site
331113000779	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
331113000780	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
331113000781	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
331113000782	30S ribosomal protein S7; Validated; Region: PRK05302
331113000783	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
331113000784	S17 interaction site [polypeptide binding]; other site
331113000785	S8 interaction site; other site
331113000786	16S rRNA interaction site [nucleotide binding]; other site
331113000787	streptomycin interaction site [chemical binding]; other site
331113000788	23S rRNA interaction site [nucleotide binding]; other site
331113000789	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
331113000790	C-terminal peptidase (prc); Region: prc; TIGR00225
331113000791	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
331113000792	protein binding site [polypeptide binding]; other site
331113000793	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
331113000794	Catalytic dyad [active]
331113000795	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
331113000796	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
331113000797	active site
331113000798	ATP binding site [chemical binding]; other site
331113000799	substrate binding site [chemical binding]; other site
331113000800	activation loop (A-loop); other site
331113000801	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
331113000802	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
331113000803	DNA binding residues [nucleotide binding]
331113000804	dimer interface [polypeptide binding]; other site
331113000805	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
331113000806	Isochorismatase family; Region: Isochorismatase; pfam00857
331113000807	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
331113000808	catalytic triad [active]
331113000809	conserved cis-peptide bond; other site
331113000810	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683
331113000811	nudix motif; other site
331113000812	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
331113000813	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
331113000814	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
331113000815	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
331113000816	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
331113000817	Surface antigen; Region: Bac_surface_Ag; pfam01103
331113000818	Uncharacterized protein conserved in archaea (DUF2073); Region: DUF2073; cl01332
331113000819	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
331113000820	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
331113000821	GTP1/OBG; Region: GTP1_OBG; pfam01018
331113000822	Obg GTPase; Region: Obg; cd01898
331113000823	G1 box; other site
331113000824	GTP/Mg2+ binding site [chemical binding]; other site
331113000825	Switch I region; other site
331113000826	G2 box; other site
331113000827	G3 box; other site
331113000828	Switch II region; other site
331113000829	G4 box; other site
331113000830	G5 box; other site
331113000831	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
331113000832	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
331113000833	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
331113000834	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
331113000835	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
331113000836	ABC-ATPase subunit  interface; other site
331113000837	dimer interface [polypeptide binding]; other site
331113000838	putative PBP binding regions; other site
331113000839	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
331113000840	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
331113000841	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
331113000842	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
331113000843	intersubunit interface [polypeptide binding]; other site
331113000844	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
331113000845	ATP cone domain; Region: ATP-cone; pfam03477
331113000846	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
331113000847	Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597
331113000848	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
331113000849	competence damage-inducible protein A; Provisional; Region: PRK00549
331113000850	putative MPT binding site; other site
331113000851	Competence-damaged protein; Region: CinA; pfam02464
331113000852	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
331113000853	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113000854	S-adenosylmethionine binding site [chemical binding]; other site
331113000855	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
331113000856	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
331113000857	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
331113000858	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
331113000859	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
331113000860	active site
331113000861	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
331113000862	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
331113000863	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
331113000864	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
331113000865	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
331113000866	dimer interface [polypeptide binding]; other site
331113000867	active site
331113000868	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
331113000869	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
331113000870	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
331113000871	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
331113000872	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
331113000873	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
331113000874	E3 interaction surface; other site
331113000875	lipoyl attachment site [posttranslational modification]; other site
331113000876	e3 binding domain; Region: E3_binding; pfam02817
331113000877	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
331113000878	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
331113000879	active site
331113000880	isocitrate dehydrogenase; Validated; Region: PRK09222
331113000881	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
331113000882	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
331113000883	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
331113000884	putative active site [active]
331113000885	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
331113000886	NHAD transporter family protein; Provisional; Region: PLN00137
331113000887	Citrate transporter; Region: CitMHS; pfam03600
331113000888	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
331113000889	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
331113000890	homodimer interface [polypeptide binding]; other site
331113000891	substrate-cofactor binding pocket; other site
331113000892	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331113000893	catalytic residue [active]
331113000894	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
331113000895	Histone H1-like protein Hc1; Region: Hc1; pfam07432
331113000896	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
331113000897	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113000898	S-adenosylmethionine binding site [chemical binding]; other site
331113000899	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
331113000900	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
331113000901	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
331113000902	Mechanosensitive ion channel; Region: MS_channel; pfam00924
331113000903	heat shock protein 90; Provisional; Region: PRK05218
331113000904	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331113000905	ATP binding site [chemical binding]; other site
331113000906	Mg2+ binding site [ion binding]; other site
331113000907	G-X-G motif; other site
331113000908	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
331113000909	Na2 binding site [ion binding]; other site
331113000910	putative substrate binding site 1 [chemical binding]; other site
331113000911	Na binding site 1 [ion binding]; other site
331113000912	putative substrate binding site 2 [chemical binding]; other site
331113000913	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
331113000914	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
331113000915	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331113000916	catalytic loop [active]
331113000917	iron binding site [ion binding]; other site
331113000918	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
331113000919	FAD binding pocket [chemical binding]; other site
331113000920	FAD binding motif [chemical binding]; other site
331113000921	phosphate binding motif [ion binding]; other site
331113000922	beta-alpha-beta structure motif; other site
331113000923	NAD binding pocket [chemical binding]; other site
331113000924	NAD synthetase; Provisional; Region: PRK13981
331113000925	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
331113000926	multimer interface [polypeptide binding]; other site
331113000927	active site
331113000928	catalytic triad [active]
331113000929	protein interface 1 [polypeptide binding]; other site
331113000930	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
331113000931	homodimer interface [polypeptide binding]; other site
331113000932	NAD binding pocket [chemical binding]; other site
331113000933	ATP binding pocket [chemical binding]; other site
331113000934	Mg binding site [ion binding]; other site
331113000935	active-site loop [active]
331113000936	Fumarase C-terminus; Region: Fumerase_C; cl00795
331113000937	fumarate hydratase; Provisional; Region: PRK06246
331113000938	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
331113000939	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
331113000940	motif 1; other site
331113000941	dimer interface [polypeptide binding]; other site
331113000942	active site
331113000943	motif 2; other site
331113000944	motif 3; other site
331113000945	elongation factor P; Validated; Region: PRK00529
331113000946	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
331113000947	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
331113000948	RNA binding site [nucleotide binding]; other site
331113000949	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
331113000950	RNA binding site [nucleotide binding]; other site
331113000951	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
331113000952	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
331113000953	Na2 binding site [ion binding]; other site
331113000954	putative substrate binding site 1 [chemical binding]; other site
331113000955	Na binding site 1 [ion binding]; other site
331113000956	putative substrate binding site 2 [chemical binding]; other site
331113000957	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
331113000958	Na2 binding site [ion binding]; other site
331113000959	putative substrate binding site 1 [chemical binding]; other site
331113000960	Na binding site 1 [ion binding]; other site
331113000961	putative substrate binding site 2 [chemical binding]; other site
331113000962	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
331113000963	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
331113000964	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
331113000965	ATP binding site [chemical binding]; other site
331113000966	putative Mg++ binding site [ion binding]; other site
331113000967	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
331113000968	nucleotide binding region [chemical binding]; other site
331113000969	ATP-binding site [chemical binding]; other site
331113000970	TRCF domain; Region: TRCF; pfam03461
331113000971	Leucine rich repeat; Region: LRR_8; pfam13855
331113000972	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
331113000973	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
331113000974	substrate binding site [chemical binding]; other site
331113000975	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
331113000976	activation loop (A-loop); other site
331113000977	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
331113000978	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
331113000979	motif 1; other site
331113000980	active site
331113000981	motif 2; other site
331113000982	motif 3; other site
331113000983	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
331113000984	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
331113000985	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
331113000986	TPP-binding site [chemical binding]; other site
331113000987	dimer interface [polypeptide binding]; other site
331113000988	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
331113000989	PYR/PP interface [polypeptide binding]; other site
331113000990	dimer interface [polypeptide binding]; other site
331113000991	TPP binding site [chemical binding]; other site
331113000992	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
331113000993	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
331113000994	substrate binding site [chemical binding]; other site
331113000995	active site
331113000996	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
331113000997	AAA domain; Region: AAA_14; pfam13173
331113000998	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
331113000999	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
331113001000	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
331113001001	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113001002	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113001003	putative substrate translocation pore; other site
331113001004	TspO/MBR family; Region: TspO_MBR; cl01379
331113001005	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
331113001006	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
331113001007	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331113001008	catalytic residue [active]
331113001009	AAA domain; Region: AAA_14; pfam13173
331113001010	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
331113001011	ribonuclease III; Reviewed; Region: rnc; PRK00102
331113001012	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
331113001013	dimerization interface [polypeptide binding]; other site
331113001014	active site
331113001015	metal binding site [ion binding]; metal-binding site
331113001016	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
331113001017	dsRNA binding site [nucleotide binding]; other site
331113001018	DNA repair protein RadA; Provisional; Region: PRK11823
331113001019	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
331113001020	Walker A motif/ATP binding site; other site
331113001021	ATP binding site [chemical binding]; other site
331113001022	Walker B motif; other site
331113001023	porphobilinogen deaminase; Provisional; Region: PRK01066
331113001024	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
331113001025	domain interfaces; other site
331113001026	active site
331113001027	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
331113001028	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
331113001029	active site
331113001030	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
331113001031	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
331113001032	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
331113001033	trimer interface [polypeptide binding]; other site
331113001034	active site
331113001035	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
331113001036	active site
331113001037	phosphorylation site [posttranslational modification]
331113001038	Predicted deacylase [General function prediction only]; Region: COG3608
331113001039	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
331113001040	putative active site [active]
331113001041	Zn binding site [ion binding]; other site
331113001042	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113001043	putative substrate translocation pore; other site
331113001044	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113001045	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
331113001046	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113001047	S-adenosylmethionine binding site [chemical binding]; other site
331113001048	TPR repeat; Region: TPR_11; pfam13414
331113001049	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331113001050	binding surface
331113001051	TPR motif; other site
331113001052	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
331113001053	Protein export membrane protein; Region: SecD_SecF; cl14618
331113001054	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
331113001055	HlyD family secretion protein; Region: HlyD_3; pfam13437
331113001056	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
331113001057	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
331113001058	DNA binding residues [nucleotide binding]
331113001059	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
331113001060	active site
331113001061	phosphorylation site [posttranslational modification]
331113001062	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
331113001063	Clp amino terminal domain; Region: Clp_N; pfam02861
331113001064	Clp amino terminal domain; Region: Clp_N; pfam02861
331113001065	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113001066	Walker A motif; other site
331113001067	ATP binding site [chemical binding]; other site
331113001068	Walker B motif; other site
331113001069	arginine finger; other site
331113001070	UvrB/uvrC motif; Region: UVR; pfam02151
331113001071	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113001072	Walker A motif; other site
331113001073	ATP binding site [chemical binding]; other site
331113001074	Walker B motif; other site
331113001075	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
331113001076	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
331113001077	prolyl-tRNA synthetase; Provisional; Region: PRK08661
331113001078	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
331113001079	dimer interface [polypeptide binding]; other site
331113001080	motif 1; other site
331113001081	active site
331113001082	motif 2; other site
331113001083	motif 3; other site
331113001084	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
331113001085	anticodon binding site; other site
331113001086	zinc-binding site [ion binding]; other site
331113001087	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
331113001088	Domain of unknown function (DUF1768); Region: DUF1768; cl01271
331113001089	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
331113001090	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113001091	putative substrate translocation pore; other site
331113001092	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113001093	Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076
331113001094	Domon-like ligand-binding domains; Region: DOMON_like; cd00241
331113001095	putative ligand binding site [chemical binding]; other site
331113001096	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
331113001097	lipoyl attachment site [posttranslational modification]; other site
331113001098	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
331113001099	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
331113001100	FMN-binding domain; Region: FMN_bind; cl01081
331113001101	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
331113001102	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024
331113001103	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
331113001104	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
331113001105	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
331113001106	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
331113001107	active site
331113001108	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
331113001109	DnaA N-terminal domain; Region: DnaA_N; pfam11638
331113001110	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113001111	Walker A motif; other site
331113001112	ATP binding site [chemical binding]; other site
331113001113	Walker B motif; other site
331113001114	arginine finger; other site
331113001115	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
331113001116	DnaA box-binding interface [nucleotide binding]; other site
331113001117	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113001118	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
331113001119	putative substrate translocation pore; other site
331113001120	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
331113001121	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
331113001122	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
331113001123	putative NAD(P) binding site [chemical binding]; other site
331113001124	putative active site [active]
331113001125	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
331113001126	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
331113001127	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
331113001128	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
331113001129	active site
331113001130	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
331113001131	active site
331113001132	catalytic residues [active]
331113001133	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331113001134	TPR motif; other site
331113001135	binding surface
331113001136	cell division protein MraZ; Reviewed; Region: PRK00326
331113001137	MraZ protein; Region: MraZ; pfam02381
331113001138	MraZ protein; Region: MraZ; pfam02381
331113001139	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113001140	S-adenosylmethionine binding site [chemical binding]; other site
331113001141	MraW methylase family; Region: Methyltransf_5; cl17771
331113001142	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
331113001143	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
331113001144	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
331113001145	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
331113001146	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
331113001147	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
331113001148	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
331113001149	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
331113001150	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
331113001151	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
331113001152	active site
331113001153	metal binding site [ion binding]; metal-binding site
331113001154	Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755
331113001155	Domain of unknown function (DUF1768); Region: DUF1768; cl01271
331113001156	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
331113001157	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
331113001158	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
331113001159	GTP-binding protein LepA; Provisional; Region: PRK05433
331113001160	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
331113001161	G1 box; other site
331113001162	putative GEF interaction site [polypeptide binding]; other site
331113001163	GTP/Mg2+ binding site [chemical binding]; other site
331113001164	Switch I region; other site
331113001165	G2 box; other site
331113001166	G3 box; other site
331113001167	Switch II region; other site
331113001168	G4 box; other site
331113001169	G5 box; other site
331113001170	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
331113001171	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
331113001172	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
331113001173	TLC ATP/ADP transporter; Region: TLC; pfam03219
331113001174	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
331113001175	Protein of unknown function (DUF971); Region: DUF971; pfam06155
331113001176	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
331113001177	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
331113001178	intersubunit interface [polypeptide binding]; other site
331113001179	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
331113001180	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
331113001181	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
331113001182	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
331113001183	ABC-ATPase subunit  interface; other site
331113001184	dimer interface [polypeptide binding]; other site
331113001185	putative PBP binding regions; other site
331113001186	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
331113001187	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
331113001188	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
331113001189	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
331113001190	ABC-ATPase subunit  interface; other site
331113001191	dimer interface [polypeptide binding]; other site
331113001192	putative PBP binding regions; other site
331113001193	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
331113001194	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
331113001195	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
331113001196	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
331113001197	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
331113001198	active site
331113001199	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
331113001200	PDZ domain; Region: PDZ_2; pfam13180
331113001201	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
331113001202	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
331113001203	putative substrate binding region [chemical binding]; other site
331113001204	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113001205	Autotransporter beta-domain; Region: Autotransporter; smart00869
331113001206	glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511
331113001207	thymidine kinase; Provisional; Region: PRK04296
331113001208	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113001209	putative substrate translocation pore; other site
331113001210	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113001211	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113001212	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113001213	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113001214	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113001215	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113001216	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113001217	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113001218	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113001219	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113001220	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113001221	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113001222	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
331113001223	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113001224	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113001225	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113001226	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113001227	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113001228	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113001229	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113001230	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113001231	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113001232	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113001233	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
331113001234	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
331113001235	nucleotide binding site [chemical binding]; other site
331113001236	putative NEF/HSP70 interaction site [polypeptide binding]; other site
331113001237	SBD interface [polypeptide binding]; other site
331113001238	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
331113001239	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
331113001240	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
331113001241	NAD binding site [chemical binding]; other site
331113001242	Phe binding site; other site
331113001243	Ubiquitin carboxyl-terminal hydrolase; Region: UCH; pfam00443
331113001244	Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cd02257
331113001245	active site
331113001246	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
331113001247	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
331113001248	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
331113001249	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
331113001250	nucleotide binding site [chemical binding]; other site
331113001251	NEF interaction site [polypeptide binding]; other site
331113001252	SBD interface [polypeptide binding]; other site
331113001253	GrpE; Region: GrpE; pfam01025
331113001254	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
331113001255	dimer interface [polypeptide binding]; other site
331113001256	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
331113001257	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
331113001258	Archaeal ATPase; Region: Arch_ATPase; pfam01637
331113001259	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
331113001260	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331113001261	putative DNA binding site [nucleotide binding]; other site
331113001262	putative Zn2+ binding site [ion binding]; other site
331113001263	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
331113001264	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
331113001265	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
331113001266	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
331113001267	Soluble P-type ATPase [General function prediction only]; Region: COG4087
331113001268	CCC1-related family of proteins; Region: CCC1_like; cl00278
331113001269	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
331113001270	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
331113001271	active site
331113001272	metal binding site [ion binding]; metal-binding site
331113001273	Peptidase family M48; Region: Peptidase_M48; pfam01435
331113001274	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
331113001275	dimer interface [polypeptide binding]; other site
331113001276	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331113001277	metal binding site [ion binding]; metal-binding site
331113001278	seryl-tRNA synthetase; Provisional; Region: PRK05431
331113001279	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
331113001280	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
331113001281	dimer interface [polypeptide binding]; other site
331113001282	active site
331113001283	motif 1; other site
331113001284	motif 2; other site
331113001285	motif 3; other site
331113001286	Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682
331113001287	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
331113001288	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
331113001289	tetramer interface [polypeptide binding]; other site
331113001290	TPP-binding site [chemical binding]; other site
331113001291	heterodimer interface [polypeptide binding]; other site
331113001292	phosphorylation loop region [posttranslational modification]
331113001293	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
331113001294	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
331113001295	alpha subunit interface [polypeptide binding]; other site
331113001296	TPP binding site [chemical binding]; other site
331113001297	heterodimer interface [polypeptide binding]; other site
331113001298	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
331113001299	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
331113001300	Response regulator receiver domain; Region: Response_reg; pfam00072
331113001301	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331113001302	active site
331113001303	phosphorylation site [posttranslational modification]
331113001304	intermolecular recognition site; other site
331113001305	dimerization interface [polypeptide binding]; other site
331113001306	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
331113001307	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
331113001308	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
331113001309	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
331113001310	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
331113001311	Competence protein; Region: Competence; pfam03772
331113001312	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
331113001313	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331113001314	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331113001315	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
331113001316	Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679
331113001317	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
331113001318	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
331113001319	Hpr binding site; other site
331113001320	active site
331113001321	homohexamer subunit interaction site [polypeptide binding]; other site
331113001322	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
331113001323	regulatory protein interface [polypeptide binding]; other site
331113001324	active site
331113001325	regulatory phosphorylation site [posttranslational modification]; other site
331113001326	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
331113001327	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
331113001328	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
331113001329	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
331113001330	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
331113001331	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
331113001332	peptide binding site [polypeptide binding]; other site
331113001333	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
331113001334	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133
331113001335	hypothetical protein; Validated; Region: PRK00153
331113001336	DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305
331113001337	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113001338	Walker A motif; other site
331113001339	ATP binding site [chemical binding]; other site
331113001340	Walker B motif; other site
331113001341	arginine finger; other site
331113001342	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
331113001343	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
331113001344	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
331113001345	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
331113001346	Zn2+ binding site [ion binding]; other site
331113001347	Mg2+ binding site [ion binding]; other site
331113001348	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
331113001349	putative ADP-ribose binding site [chemical binding]; other site
331113001350	putative active site [active]
331113001351	Ubiquitin-like proteins; Region: UBQ; cl00155
331113001352	charged pocket; other site
331113001353	hydrophobic patch; other site
331113001354	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
331113001355	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331113001356	NAD(P) binding site [chemical binding]; other site
331113001357	active site
331113001358	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
331113001359	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
331113001360	active site
331113001361	substrate binding site [chemical binding]; other site
331113001362	metal binding site [ion binding]; metal-binding site
331113001363	Flagellin N-methylase; Region: FliB; pfam03692
331113001364	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
331113001365	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
331113001366	putative active site [active]
331113001367	putative metal binding site [ion binding]; other site
331113001368	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
331113001369	active site
331113001370	metal binding site [ion binding]; metal-binding site
331113001371	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
331113001372	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
331113001373	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
331113001374	active site
331113001375	P-loop; other site
331113001376	phosphorylation site [posttranslational modification]
331113001377	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
331113001378	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
331113001379	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
331113001380	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
331113001381	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
331113001382	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
331113001383	ring oligomerisation interface [polypeptide binding]; other site
331113001384	ATP/Mg binding site [chemical binding]; other site
331113001385	stacking interactions; other site
331113001386	hinge regions; other site
331113001387	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
331113001388	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
331113001389	dimerization interface [polypeptide binding]; other site
331113001390	active site
331113001391	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113001392	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113001393	putative substrate translocation pore; other site
331113001394	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113001395	putative RNA ligase; Region: PHA02142
331113001396	Uncharacterized conserved protein [Function unknown]; Region: COG1284
331113001397	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
331113001398	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331113001399	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113001400	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113001401	putative substrate translocation pore; other site
331113001402	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
331113001403	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
331113001404	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
331113001405	Na binding site [ion binding]; other site
331113001406	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
331113001407	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
331113001408	Ligand Binding Site [chemical binding]; other site
331113001409	SEC-C motif; Region: SEC-C; pfam02810
331113001410	Methyltransferase domain; Region: Methyltransf_23; pfam13489
331113001411	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113001412	S-adenosylmethionine binding site [chemical binding]; other site
331113001413	arginine decarboxylase; Provisional; Region: PRK05354
331113001414	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
331113001415	dimer interface [polypeptide binding]; other site
331113001416	active site
331113001417	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
331113001418	catalytic residues [active]
331113001419	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
331113001420	agmatinase; Region: agmatinase; TIGR01230
331113001421	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
331113001422	putative active site [active]
331113001423	Mn binding site [ion binding]; other site
331113001424	Deoxyhypusine synthase; Region: DS; cl00826
331113001425	deoxyhypusine synthase; Region: dhys; TIGR00321
331113001426	Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119
331113001427	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
331113001428	catalytic residues [active]
331113001429	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
331113001430	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
331113001431	Amidase; Region: Amidase; cl11426
331113001432	TROVE domain; Region: TROVE; pfam05731
331113001433	SET domain; Region: SET; pfam00856
331113001434	Domain of unknown function (DUF378); Region: DUF378; pfam04070
331113001435	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
331113001436	trimer interface [polypeptide binding]; other site
331113001437	active site
331113001438	substrate binding site [chemical binding]; other site
331113001439	CoA binding site [chemical binding]; other site
331113001440	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
331113001441	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
331113001442	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
331113001443	active site
331113001444	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
331113001445	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
331113001446	adenylate kinase; Reviewed; Region: adk; PRK00279
331113001447	AMP-binding site [chemical binding]; other site
331113001448	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
331113001449	hypothetical protein; Provisional; Region: PRK06849
331113001450	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
331113001451	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
331113001452	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
331113001453	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
331113001454	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
331113001455	Dienelactone hydrolase family; Region: DLH; pfam01738
331113001456	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
331113001457	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
331113001458	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
331113001459	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
331113001460	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331113001461	FeS/SAM binding site; other site
331113001462	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
331113001463	putative transporter; Provisional; Region: PRK11660
331113001464	Sulfate transporter family; Region: Sulfate_transp; pfam00916
331113001465	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
331113001466	BioY family; Region: BioY; pfam02632
331113001467	metabolite-proton symporter; Region: 2A0106; TIGR00883
331113001468	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113001469	putative substrate translocation pore; other site
331113001470	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144
331113001471	conserved cys residue [active]
331113001472	Amino acid permease; Region: AA_permease; pfam00324
331113001473	methionine sulfoxide reductase A; Provisional; Region: PRK14054
331113001474	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
331113001475	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
331113001476	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
331113001477	protein binding site [polypeptide binding]; other site
331113001478	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
331113001479	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
331113001480	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
331113001481	active site
331113001482	Zn binding site [ion binding]; other site
331113001483	Phytase; Region: Phytase; cl17685
331113001484	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
331113001485	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
331113001486	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
331113001487	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
331113001488	Walker A/P-loop; other site
331113001489	ATP binding site [chemical binding]; other site
331113001490	Q-loop/lid; other site
331113001491	ABC transporter signature motif; other site
331113001492	Walker B; other site
331113001493	D-loop; other site
331113001494	H-loop/switch region; other site
331113001495	DevC protein; Region: devC; TIGR01185
331113001496	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
331113001497	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331113001498	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331113001499	HlyD family secretion protein; Region: HlyD_3; pfam13437
331113001500	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113001501	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113001502	putative substrate translocation pore; other site
331113001503	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
331113001504	Zn binding site [ion binding]; other site
331113001505	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
331113001506	Archease protein family (MTH1598/TM1083); Region: Archease; cl00606
331113001507	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
331113001508	hypothetical protein; Reviewed; Region: PRK09588
331113001509	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
331113001510	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
331113001511	EamA-like transporter family; Region: EamA; pfam00892
331113001512	Class I aldolases; Region: Aldolase_Class_I; cl17187
331113001513	catalytic residue [active]
331113001514	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
331113001515	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
331113001516	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
331113001517	ligand binding site [chemical binding]; other site
331113001518	flexible hinge region; other site
331113001519	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
331113001520	TM2 domain; Region: TM2; cl00984
331113001521	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
331113001522	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
331113001523	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
331113001524	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
331113001525	active site residue [active]
331113001526	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
331113001527	active site residue [active]
331113001528	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133
331113001529	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
331113001530	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133
331113001531	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
331113001532	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
331113001533	beta-galactosidase; Region: BGL; TIGR03356
331113001534	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
331113001535	Phosphotransferase enzyme family; Region: APH; pfam01636
331113001536	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
331113001537	ATP binding site [chemical binding]; other site
331113001538	EamA-like transporter family; Region: EamA; pfam00892
331113001539	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
331113001540	EamA-like transporter family; Region: EamA; pfam00892
331113001541	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
331113001542	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
331113001543	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
331113001544	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
331113001545	Mechanosensitive ion channel; Region: MS_channel; pfam00924
331113001546	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
331113001547	putative GSH binding site [chemical binding]; other site
331113001548	catalytic residues [active]
331113001549	BolA-like protein; Region: BolA; pfam01722
331113001550	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331113001551	TPR repeat; Region: TPR_11; pfam13414
331113001552	TPR motif; other site
331113001553	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
331113001554	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
331113001555	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
331113001556	putative active site [active]
331113001557	putative substrate binding site [chemical binding]; other site
331113001558	putative cosubstrate binding site; other site
331113001559	catalytic site [active]
331113001560	Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677
331113001561	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
331113001562	malate dehydrogenase; Provisional; Region: PRK05442
331113001563	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
331113001564	NAD(P) binding site [chemical binding]; other site
331113001565	dimer interface [polypeptide binding]; other site
331113001566	malate binding site [chemical binding]; other site
331113001567	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
331113001568	Citrate synthase; Region: Citrate_synt; pfam00285
331113001569	oxalacetate binding site [chemical binding]; other site
331113001570	citrylCoA binding site [chemical binding]; other site
331113001571	coenzyme A binding site [chemical binding]; other site
331113001572	catalytic triad [active]
331113001573	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
331113001574	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331113001575	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
331113001576	putative hydrolase; Provisional; Region: PRK02113
331113001577	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
331113001578	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
331113001579	HflX GTPase family; Region: HflX; cd01878
331113001580	G1 box; other site
331113001581	GTP/Mg2+ binding site [chemical binding]; other site
331113001582	Switch I region; other site
331113001583	G2 box; other site
331113001584	G3 box; other site
331113001585	Switch II region; other site
331113001586	G4 box; other site
331113001587	G5 box; other site
331113001588	hypothetical protein; Reviewed; Region: PRK00024
331113001589	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
331113001590	MPN+ (JAMM) motif; other site
331113001591	Zinc-binding site [ion binding]; other site
331113001592	MarC family integral membrane protein; Region: MarC; pfam01914
331113001593	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
331113001594	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
331113001595	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331113001596	FeS/SAM binding site; other site
331113001597	Protein of unknown function (DUF2000); Region: DUF2000; pfam09391
331113001598	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
331113001599	AzlC protein; Region: AzlC; cl00570
331113001600	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
331113001601	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
331113001602	glycogen branching enzyme; Provisional; Region: PRK05402
331113001603	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
331113001604	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
331113001605	active site
331113001606	catalytic site [active]
331113001607	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
331113001608	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
331113001609	nucleotide binding pocket [chemical binding]; other site
331113001610	K-X-D-G motif; other site
331113001611	catalytic site [active]
331113001612	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
331113001613	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
331113001614	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
331113001615	Dimer interface [polypeptide binding]; other site
331113001616	BRCT sequence motif; other site
331113001617	Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119
331113001618	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
331113001619	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
331113001620	TRAM domain; Region: TRAM; cl01282
331113001621	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
331113001622	23S rRNA interface [nucleotide binding]; other site
331113001623	L3 interface [polypeptide binding]; other site
331113001624	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
331113001625	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331113001626	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
331113001627	active site
331113001628	Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346
331113001629	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331113001630	active site
331113001631	MIP family channel proteins; Region: MIP; TIGR00861
331113001632	amphipathic channel; other site
331113001633	Asn-Pro-Ala signature motifs; other site
331113001634	TIGR02452 family protein; Region: TIGR02452
331113001635	Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021
331113001636	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
331113001637	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
331113001638	active site
331113001639	Zn binding site [ion binding]; other site
331113001640	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
331113001641	active site
331113001642	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
331113001643	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
331113001644	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
331113001645	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
331113001646	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
331113001647	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
331113001648	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
331113001649	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113001650	Walker A motif; other site
331113001651	ATP binding site [chemical binding]; other site
331113001652	Walker B motif; other site
331113001653	arginine finger; other site
331113001654	Peptidase family M41; Region: Peptidase_M41; pfam01434
331113001655	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
331113001656	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
331113001657	active site
331113001658	metal binding site [ion binding]; metal-binding site
331113001659	Protein of unknown function (DUF692); Region: DUF692; cl01263
331113001660	polyribonucleotide nucleotidyltransferase; Region: polynuc_phos; TIGR03591
331113001661	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
331113001662	oligomer interface [polypeptide binding]; other site
331113001663	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
331113001664	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
331113001665	RNase E interface [polypeptide binding]; other site
331113001666	trimer interface [polypeptide binding]; other site
331113001667	active site
331113001668	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
331113001669	putative nucleic acid binding region [nucleotide binding]; other site
331113001670	G-X-X-G motif; other site
331113001671	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
331113001672	RNA binding site [nucleotide binding]; other site
331113001673	domain interface; other site
331113001674	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
331113001675	16S/18S rRNA binding site [nucleotide binding]; other site
331113001676	S13e-L30e interaction site [polypeptide binding]; other site
331113001677	25S rRNA binding site [nucleotide binding]; other site
331113001678	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
331113001679	nucleoside/Zn binding site; other site
331113001680	dimer interface [polypeptide binding]; other site
331113001681	catalytic motif [active]
331113001682	Rhomboid family; Region: Rhomboid; cl11446
331113001683	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
331113001684	peptide chain release factor 1; Validated; Region: prfA; PRK00591
331113001685	PCRF domain; Region: PCRF; pfam03462
331113001686	RF-1 domain; Region: RF-1; pfam00472
331113001687	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
331113001688	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
331113001689	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
331113001690	signal recognition particle protein; Provisional; Region: PRK10867
331113001691	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
331113001692	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
331113001693	P loop; other site
331113001694	GTP binding site [chemical binding]; other site
331113001695	Signal peptide binding domain; Region: SRP_SPB; pfam02978
331113001696	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
331113001697	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
331113001698	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
331113001699	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
331113001700	RNA/DNA hybrid binding site [nucleotide binding]; other site
331113001701	active site
331113001702	hypothetical protein; Provisional; Region: PRK11820
331113001703	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
331113001704	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
331113001705	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
331113001706	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
331113001707	catalytic site [active]
331113001708	G-X2-G-X-G-K; other site
331113001709	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
331113001710	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
331113001711	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
331113001712	active site
331113001713	HIGH motif; other site
331113001714	KMSKS motif; other site
331113001715	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
331113001716	tRNA binding surface [nucleotide binding]; other site
331113001717	anticodon binding site; other site
331113001718	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
331113001719	dimer interface [polypeptide binding]; other site
331113001720	putative tRNA-binding site [nucleotide binding]; other site
331113001721	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
331113001722	AAA domain; Region: AAA_30; pfam13604
331113001723	Family description; Region: UvrD_C_2; pfam13538
331113001724	N-acetyltransferase; Region: Acetyltransf_2; cl00949
331113001725	N-acetyltransferase; Region: Acetyltransf_2; cl00949
331113001726	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
331113001727	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
331113001728	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331113001729	Coenzyme A binding pocket [chemical binding]; other site
331113001730	Predicted amidohydrolase [General function prediction only]; Region: COG0388
331113001731	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
331113001732	putative active site [active]
331113001733	catalytic triad [active]
331113001734	putative dimer interface [polypeptide binding]; other site
331113001735	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
331113001736	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
331113001737	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
331113001738	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
331113001739	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
331113001740	nudix motif; other site
331113001741	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
331113001742	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113001743	S-adenosylmethionine binding site [chemical binding]; other site
331113001744	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
331113001745	LicD family; Region: LicD; pfam04991
331113001746	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
331113001747	glucose-1-dehydrogenase; Provisional; Region: PRK08936
331113001748	NAD binding site [chemical binding]; other site
331113001749	homodimer interface [polypeptide binding]; other site
331113001750	active site
331113001751	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
331113001752	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
331113001753	ring oligomerisation interface [polypeptide binding]; other site
331113001754	ATP/Mg binding site [chemical binding]; other site
331113001755	stacking interactions; other site
331113001756	hinge regions; other site
331113001757	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
331113001758	oligomerisation interface [polypeptide binding]; other site
331113001759	mobile loop; other site
331113001760	roof hairpin; other site
331113001761	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
331113001762	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
331113001763	Zn2+ binding site [ion binding]; other site
331113001764	Mg2+ binding site [ion binding]; other site
331113001765	oligoendopeptidase F; Region: pepF; TIGR00181
331113001766	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
331113001767	active site
331113001768	Zn binding site [ion binding]; other site
331113001769	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
331113001770	dimerization domain swap beta strand [polypeptide binding]; other site
331113001771	regulatory protein interface [polypeptide binding]; other site
331113001772	active site
331113001773	regulatory phosphorylation site [posttranslational modification]; other site
331113001774	Bifunctional nuclease; Region: DNase-RNase; pfam02577
331113001775	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
331113001776	tetramer (dimer of dimers) interface [polypeptide binding]; other site
331113001777	active site
331113001778	dimer interface [polypeptide binding]; other site
331113001779	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
331113001780	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
331113001781	active site
331113001782	HIGH motif; other site
331113001783	dimer interface [polypeptide binding]; other site
331113001784	KMSKS motif; other site
331113001785	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
331113001786	RNA binding surface [nucleotide binding]; other site
331113001787	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
331113001788	IHF - DNA interface [nucleotide binding]; other site
331113001789	IHF dimer interface [polypeptide binding]; other site
331113001790	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
331113001791	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
331113001792	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
331113001793	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
331113001794	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
331113001795	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
331113001796	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331113001797	Walker A/P-loop; other site
331113001798	ATP binding site [chemical binding]; other site
331113001799	Q-loop/lid; other site
331113001800	ABC transporter signature motif; other site
331113001801	Walker B; other site
331113001802	D-loop; other site
331113001803	H-loop/switch region; other site
331113001804	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
331113001805	sequence-specific DNA binding site [nucleotide binding]; other site
331113001806	salt bridge; other site
331113001807	DNA polymerase III subunit epsilon; Validated; Region: PRK06309
331113001808	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
331113001809	active site
331113001810	catalytic site [active]
331113001811	substrate binding site [chemical binding]; other site
331113001812	Protein of unknown function (DUF3820); Region: DUF3820; cl01411
331113001813	Family of unknown function (DUF3836); Region: DUF3836; pfam12930
331113001814	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
331113001815	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
331113001816	tetramer interface [polypeptide binding]; other site
331113001817	TPP-binding site [chemical binding]; other site
331113001818	heterodimer interface [polypeptide binding]; other site
331113001819	phosphorylation loop region [posttranslational modification]
331113001820	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
331113001821	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
331113001822	alpha subunit interface [polypeptide binding]; other site
331113001823	TPP binding site [chemical binding]; other site
331113001824	heterodimer interface [polypeptide binding]; other site
331113001825	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
331113001826	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
331113001827	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
331113001828	E3 interaction surface; other site
331113001829	lipoyl attachment site [posttranslational modification]; other site
331113001830	e3 binding domain; Region: E3_binding; pfam02817
331113001831	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
331113001832	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
331113001833	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
331113001834	Cl binding site [ion binding]; other site
331113001835	oligomer interface [polypeptide binding]; other site
331113001836	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
331113001837	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
331113001838	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
331113001839	trimer interface [polypeptide binding]; other site
331113001840	active site
331113001841	UDP-GlcNAc binding site [chemical binding]; other site
331113001842	lipid binding site [chemical binding]; lipid-binding site
331113001843	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
331113001844	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
331113001845	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
331113001846	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
331113001847	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
331113001848	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
331113001849	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
331113001850	Surface antigen; Region: Bac_surface_Ag; pfam01103
331113001851	recombination protein RecR; Reviewed; Region: recR; PRK00076
331113001852	RecR protein; Region: RecR; pfam02132
331113001853	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
331113001854	putative active site [active]
331113001855	putative metal-binding site [ion binding]; other site
331113001856	tetramer interface [polypeptide binding]; other site
331113001857	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
331113001858	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
331113001859	dimer interface [polypeptide binding]; other site
331113001860	active site
331113001861	CoA binding pocket [chemical binding]; other site
331113001862	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
331113001863	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
331113001864	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
331113001865	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
331113001866	NAD(P) binding site [chemical binding]; other site
331113001867	homotetramer interface [polypeptide binding]; other site
331113001868	homodimer interface [polypeptide binding]; other site
331113001869	active site
331113001870	acyl carrier protein; Provisional; Region: acpP; PRK00982
331113001871	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113001872	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113001873	putative substrate translocation pore; other site
331113001874	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113001875	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113001876	putative substrate translocation pore; other site
331113001877	Fatty acid desaturase; Region: FA_desaturase; pfam00487
331113001878	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
331113001879	Di-iron ligands [ion binding]; other site
331113001880	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
331113001881	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
331113001882	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
331113001883	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331113001884	dimer interface [polypeptide binding]; other site
331113001885	conserved gate region; other site
331113001886	putative PBP binding loops; other site
331113001887	ABC-ATPase subunit interface; other site
331113001888	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
331113001889	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331113001890	dimer interface [polypeptide binding]; other site
331113001891	conserved gate region; other site
331113001892	putative PBP binding loops; other site
331113001893	ABC-ATPase subunit interface; other site
331113001894	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
331113001895	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331113001896	Walker A/P-loop; other site
331113001897	ATP binding site [chemical binding]; other site
331113001898	Q-loop/lid; other site
331113001899	ABC transporter signature motif; other site
331113001900	Walker B; other site
331113001901	D-loop; other site
331113001902	H-loop/switch region; other site
331113001903	TOBE domain; Region: TOBE_2; pfam08402
331113001904	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
331113001905	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331113001906	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331113001907	Cupin domain; Region: Cupin_2; cl17218
331113001908	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
331113001909	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
331113001910	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
331113001911	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
331113001912	putative active site [active]
331113001913	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
331113001914	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
331113001915	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
331113001916	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
331113001917	HIT family signature motif; other site
331113001918	catalytic residue [active]
331113001919	Sm and related proteins; Region: Sm_like; cl00259
331113001920	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
331113001921	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
331113001922	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
331113001923	dimer interface [polypeptide binding]; other site
331113001924	ssDNA binding site [nucleotide binding]; other site
331113001925	tetramer (dimer of dimers) interface [polypeptide binding]; other site
331113001926	multifunctional aminopeptidase A; Provisional; Region: PRK00913
331113001927	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
331113001928	interface (dimer of trimers) [polypeptide binding]; other site
331113001929	Substrate-binding/catalytic site; other site
331113001930	Zn-binding sites [ion binding]; other site
331113001931	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
331113001932	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
331113001933	active site
331113001934	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
331113001935	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113001936	putative substrate translocation pore; other site
331113001937	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
331113001938	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
331113001939	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
331113001940	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
331113001941	AAA domain; Region: AAA_26; pfam13500
331113001942	DRTGG domain; Region: DRTGG; pfam07085
331113001943	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
331113001944	nudix motif; other site
331113001945	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
331113001946	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333
331113001947	homodimer interface [polypeptide binding]; other site
331113001948	metal binding site [ion binding]; metal-binding site
331113001949	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
331113001950	Protein of unknown function (DUF1551); Region: DUF1551; pfam07585
331113001951	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
331113001952	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
331113001953	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
331113001954	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
331113001955	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
331113001956	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
331113001957	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
331113001958	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
331113001959	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331113001960	Walker A/P-loop; other site
331113001961	ATP binding site [chemical binding]; other site
331113001962	Q-loop/lid; other site
331113001963	ABC transporter signature motif; other site
331113001964	Walker B; other site
331113001965	D-loop; other site
331113001966	H-loop/switch region; other site
331113001967	pyruvate kinase; Provisional; Region: PRK05826
331113001968	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
331113001969	domain interfaces; other site
331113001970	active site
331113001971	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
331113001972	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
331113001973	phosphoenolpyruvate synthase; Validated; Region: PRK06464
331113001974	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
331113001975	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
331113001976	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
331113001977	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
331113001978	lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906
331113001979	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
331113001980	putative acyl-acceptor binding pocket; other site
331113001981	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
331113001982	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
331113001983	Uncharacterized conserved protein [Function unknown]; Region: COG1624
331113001984	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
331113001985	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
331113001986	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
331113001987	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
331113001988	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
331113001989	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
331113001990	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
331113001991	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
331113001992	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
331113001993	TPP-binding site; other site
331113001994	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
331113001995	PYR/PP interface [polypeptide binding]; other site
331113001996	dimer interface [polypeptide binding]; other site
331113001997	TPP binding site [chemical binding]; other site
331113001998	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
331113001999	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
331113002000	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
331113002001	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
331113002002	generic binding surface I; other site
331113002003	generic binding surface II; other site
331113002004	Merozoite surface protein 1 (MSP1) C-terminus; Region: MSP1_C; pfam07462
331113002005	triosephosphate isomerase; Provisional; Region: PRK14565
331113002006	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
331113002007	substrate binding site [chemical binding]; other site
331113002008	dimer interface [polypeptide binding]; other site
331113002009	catalytic triad [active]
331113002010	Preprotein translocase SecG subunit; Region: SecG; pfam03840
331113002011	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
331113002012	active site
331113002013	catalytic residues [active]
331113002014	metal binding site [ion binding]; metal-binding site
331113002015	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
331113002016	HEAT repeats; Region: HEAT_2; pfam13646
331113002017	HEAT repeats; Region: HEAT_2; pfam13646
331113002018	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
331113002019	protein binding surface [polypeptide binding]; other site
331113002020	HEAT repeats; Region: HEAT_2; pfam13646
331113002021	Maf-like protein; Region: Maf; pfam02545
331113002022	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
331113002023	active site
331113002024	dimer interface [polypeptide binding]; other site
331113002025	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
331113002026	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
331113002027	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
331113002028	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
331113002029	Transporter associated domain; Region: CorC_HlyC; smart01091
331113002030	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113002031	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113002032	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113002033	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
331113002034	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113002035	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
331113002036	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
331113002037	Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137
331113002038	Uncharacterized conserved protein [Function unknown]; Region: COG2155
331113002039	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
331113002040	DNA photolyase; Region: DNA_photolyase; pfam00875
331113002041	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331113002042	WHG domain; Region: WHG; pfam13305
331113002043	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106
331113002044	Protein of unknown function (DUF502); Region: DUF502; cl01107
331113002045	Uncharacterized conserved protein [Function unknown]; Region: COG2928
331113002046	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
331113002047	active site
331113002048	DNA binding site [nucleotide binding]
331113002049	VacB and RNase II family 3'-5' exoribonucleases; Region: 3_prime_RNase; TIGR00358
331113002050	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
331113002051	RNB domain; Region: RNB; pfam00773
331113002052	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
331113002053	RNA binding site [nucleotide binding]; other site
331113002054	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
331113002055	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
331113002056	ATP binding site [chemical binding]; other site
331113002057	substrate interface [chemical binding]; other site
331113002058	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
331113002059	active site residue [active]
331113002060	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
331113002061	MoaE interaction surface [polypeptide binding]; other site
331113002062	MoeB interaction surface [polypeptide binding]; other site
331113002063	thiocarboxylated glycine; other site
331113002064	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
331113002065	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
331113002066	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
331113002067	Uncharacterized conserved protein [Function unknown]; Region: COG1944
331113002068	YcaO-like family; Region: YcaO; pfam02624
331113002069	TfuA-like protein; Region: TfuA; pfam07812
331113002070	NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797
331113002071	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331113002072	Walker A/P-loop; other site
331113002073	ATP binding site [chemical binding]; other site
331113002074	Q-loop/lid; other site
331113002075	ABC transporter signature motif; other site
331113002076	Walker B; other site
331113002077	D-loop; other site
331113002078	H-loop/switch region; other site
331113002079	NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796
331113002080	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
331113002081	putative active site [active]
331113002082	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
331113002083	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331113002084	Walker A/P-loop; other site
331113002085	ATP binding site [chemical binding]; other site
331113002086	Q-loop/lid; other site
331113002087	ABC transporter signature motif; other site
331113002088	Walker B; other site
331113002089	D-loop; other site
331113002090	H-loop/switch region; other site
331113002091	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
331113002092	lipoyl-biotinyl attachment site [posttranslational modification]; other site
331113002093	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
331113002094	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331113002095	motif II; other site
331113002096	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
331113002097	ApbE family; Region: ApbE; pfam02424
331113002098	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
331113002099	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
331113002100	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
331113002101	homodimer interface [polypeptide binding]; other site
331113002102	NADP binding site [chemical binding]; other site
331113002103	substrate binding site [chemical binding]; other site
331113002104	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
331113002105	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
331113002106	active site
331113002107	dimerization interface [polypeptide binding]; other site
331113002108	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
331113002109	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331113002110	NAD(P) binding site [chemical binding]; other site
331113002111	active site
331113002112	Bacterial sugar transferase; Region: Bac_transf; pfam02397
331113002113	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
331113002114	active site
331113002115	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
331113002116	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
331113002117	substrate binding pocket [chemical binding]; other site
331113002118	chain length determination region; other site
331113002119	substrate-Mg2+ binding site; other site
331113002120	catalytic residues [active]
331113002121	aspartate-rich region 1; other site
331113002122	active site lid residues [active]
331113002123	aspartate-rich region 2; other site
331113002124	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
331113002125	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
331113002126	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
331113002127	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
331113002128	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
331113002129	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
331113002130	Walker A/P-loop; other site
331113002131	ATP binding site [chemical binding]; other site
331113002132	Q-loop/lid; other site
331113002133	ABC transporter signature motif; other site
331113002134	Walker B; other site
331113002135	D-loop; other site
331113002136	H-loop/switch region; other site
331113002137	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
331113002138	FtsX-like permease family; Region: FtsX; pfam02687
331113002139	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
331113002140	tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723
331113002141	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
331113002142	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); Region: PCMT; pfam01135
331113002143	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113002144	S-adenosylmethionine binding site [chemical binding]; other site
331113002145	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
331113002146	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
331113002147	putative active site [active]
331113002148	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
331113002149	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
331113002150	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
331113002151	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
331113002152	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331113002153	Quinolinate synthetase A protein; Region: NadA; pfam02445
331113002154	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
331113002155	CTP synthetase; Validated; Region: pyrG; PRK05380
331113002156	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
331113002157	Catalytic site [active]
331113002158	active site
331113002159	UTP binding site [chemical binding]; other site
331113002160	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
331113002161	active site
331113002162	putative oxyanion hole; other site
331113002163	catalytic triad [active]
331113002164	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
331113002165	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113002166	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
331113002167	Walker A motif; other site
331113002168	ATP binding site [chemical binding]; other site
331113002169	Walker B motif; other site
331113002170	arginine finger; other site
331113002171	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
331113002172	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
331113002173	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
331113002174	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
331113002175	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085
331113002176	pyrophosphate-dependent phosphofructokinase; Region: PLN02251
331113002177	active site
331113002178	ADP/pyrophosphate binding site [chemical binding]; other site
331113002179	dimerization interface [polypeptide binding]; other site
331113002180	allosteric effector site; other site
331113002181	fructose-1,6-bisphosphate binding site; other site
331113002182	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
331113002183	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
331113002184	Methyltransferase domain; Region: Methyltransf_31; pfam13847
331113002185	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113002186	S-adenosylmethionine binding site [chemical binding]; other site
331113002187	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
331113002188	aromatic arch; other site
331113002189	DCoH dimer interaction site [polypeptide binding]; other site
331113002190	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
331113002191	DCoH tetramer interaction site [polypeptide binding]; other site
331113002192	substrate binding site [chemical binding]; other site
331113002193	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
331113002194	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Region: PLN02925
331113002195	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
331113002196	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
331113002197	metal binding site [ion binding]; metal-binding site
331113002198	dimer interface [polypeptide binding]; other site
331113002199	recombination factor protein RarA; Reviewed; Region: PRK13342
331113002200	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113002201	Walker A motif; other site
331113002202	ATP binding site [chemical binding]; other site
331113002203	Walker B motif; other site
331113002204	arginine finger; other site
331113002205	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
331113002206	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
331113002207	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
331113002208	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
331113002209	C-terminal domain interface [polypeptide binding]; other site
331113002210	GSH binding site (G-site) [chemical binding]; other site
331113002211	dimer interface [polypeptide binding]; other site
331113002212	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
331113002213	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
331113002214	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331113002215	Walker A/P-loop; other site
331113002216	ATP binding site [chemical binding]; other site
331113002217	Q-loop/lid; other site
331113002218	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
331113002219	ABC transporter signature motif; other site
331113002220	Walker B; other site
331113002221	D-loop; other site
331113002222	ABC transporter; Region: ABC_tran_2; pfam12848
331113002223	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
331113002224	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
331113002225	putative FMN binding site [chemical binding]; other site
331113002226	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
331113002227	active site
331113002228	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
331113002229	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
331113002230	ribonuclease Y; Region: RNase_Y; TIGR03319
331113002231	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
331113002232	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
331113002233	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
331113002234	Transmembrane proteins 14C; Region: Tmemb_14; cl02346
331113002235	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
331113002236	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
331113002237	catalytic core [active]
331113002238	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
331113002239	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
331113002240	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
331113002241	ATP-binding site [chemical binding]; other site
331113002242	Sugar specificity; other site
331113002243	Pyrimidine base specificity; other site
331113002244	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
331113002245	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
331113002246	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
331113002247	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
331113002248	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
331113002249	putative NAD(P) binding site [chemical binding]; other site
331113002250	putative active site [active]
331113002251	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
331113002252	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
331113002253	Catalytic site [active]
331113002254	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
331113002255	Trehalase; Region: Trehalase; cl17346
331113002256	Serpentine type 7TM GPCR chemoreceptor Srh; Region: 7TM_GPCR_Srh; cl11665
331113002257	Sulfatase; Region: Sulfatase; cl17466
331113002258	Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; Region: H2A; cl00074
331113002259	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
331113002260	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
331113002261	guanine deaminase; Region: guan_deamin; TIGR02967
331113002262	active site
331113002263	Trp repressor protein; Region: Trp_repressor; cl17266
331113002264	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
331113002265	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
331113002266	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
331113002267	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
331113002268	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
331113002269	glutamine binding [chemical binding]; other site
331113002270	catalytic triad [active]
331113002271	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
331113002272	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
331113002273	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
331113002274	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
331113002275	active site
331113002276	ribulose/triose binding site [chemical binding]; other site
331113002277	phosphate binding site [ion binding]; other site
331113002278	substrate (anthranilate) binding pocket [chemical binding]; other site
331113002279	product (indole) binding pocket [chemical binding]; other site
331113002280	phosphoribosylanthranilate isomerase; Region: PLN02363
331113002281	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
331113002282	active site
331113002283	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
331113002284	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
331113002285	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331113002286	catalytic residue [active]
331113002287	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
331113002288	substrate binding site [chemical binding]; other site
331113002289	active site
331113002290	catalytic residues [active]
331113002291	heterodimer interface [polypeptide binding]; other site
331113002292	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
331113002293	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
331113002294	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
331113002295	ATP-grasp domain; Region: ATP-grasp_4; cl17255
331113002296	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
331113002297	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
331113002298	putative active site [active]
331113002299	putative dimer interface [polypeptide binding]; other site
331113002300	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331113002301	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
331113002302	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
331113002303	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
331113002304	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
331113002305	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331113002306	substrate binding pocket [chemical binding]; other site
331113002307	membrane-bound complex binding site; other site
331113002308	hinge residues; other site
331113002309	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
331113002310	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
331113002311	active site
331113002312	dihydrodipicolinate reductase; Provisional; Region: PRK00048
331113002313	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
331113002314	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
331113002315	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
331113002316	dihydrodipicolinate synthase; Region: dapA; TIGR00674
331113002317	dimer interface [polypeptide binding]; other site
331113002318	active site
331113002319	catalytic residue [active]
331113002320	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
331113002321	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
331113002322	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
331113002323	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331113002324	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331113002325	homodimer interface [polypeptide binding]; other site
331113002326	catalytic residue [active]
331113002327	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
331113002328	trimer interface [polypeptide binding]; other site
331113002329	putative Zn binding site [ion binding]; other site
331113002330	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
331113002331	RF-1 domain; Region: RF-1; pfam00472
331113002332	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
331113002333	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
331113002334	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
331113002335	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
331113002336	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
331113002337	peptide binding site [polypeptide binding]; other site
331113002338	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
331113002339	Src homology 2 (SH2) domain; Region: SH2; cd00173
331113002340	phosphotyrosine binding pocket [polypeptide binding]; other site
331113002341	hydrophobic binding pocket [polypeptide binding]; other site
331113002342	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133
331113002343	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
331113002344	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
331113002345	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
331113002346	peptide binding site [polypeptide binding]; other site
331113002347	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
331113002348	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
331113002349	peptide binding site [polypeptide binding]; other site
331113002350	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
331113002351	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
331113002352	ATP-grasp domain; Region: ATP-grasp_4; cl17255
331113002353	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331113002354	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
331113002355	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331113002356	HlyD family secretion protein; Region: HlyD_3; pfam13437
331113002357	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113002358	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331113002359	putative substrate translocation pore; other site
331113002360	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113002361	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113002362	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
331113002363	putative substrate translocation pore; other site
331113002364	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
331113002365	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
331113002366	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
331113002367	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
331113002368	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
331113002369	active site
331113002370	substrate binding site [chemical binding]; other site
331113002371	activation loop (A-loop); other site
331113002372	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
331113002373	Catalytic domain of Protein Kinases; Region: PKc; cd00180
331113002374	active site
331113002375	ATP binding site [chemical binding]; other site
331113002376	substrate binding site [chemical binding]; other site
331113002377	activation loop (A-loop); other site
331113002378	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
331113002379	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
331113002380	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
331113002381	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
331113002382	homodimer interface [polypeptide binding]; other site
331113002383	chemical substrate binding site [chemical binding]; other site
331113002384	oligomer interface [polypeptide binding]; other site
331113002385	metal binding site [ion binding]; metal-binding site
331113002386	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
331113002387	transmembrane helices; other site
331113002388	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
331113002389	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
331113002390	ABC-2 type transporter; Region: ABC2_membrane; cl17235
331113002391	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
331113002392	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
331113002393	Walker A/P-loop; other site
331113002394	ATP binding site [chemical binding]; other site
331113002395	Q-loop/lid; other site
331113002396	ABC transporter signature motif; other site
331113002397	Walker B; other site
331113002398	D-loop; other site
331113002399	H-loop/switch region; other site
331113002400	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017
331113002401	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
331113002402	active site
331113002403	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
331113002404	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
331113002405	peptide binding site [polypeptide binding]; other site
331113002406	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
331113002407	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
331113002408	peptide binding site [polypeptide binding]; other site
331113002409	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113002410	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113002411	putative substrate translocation pore; other site
331113002412	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113002413	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
331113002414	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
331113002415	active site
331113002416	hypothetical protein; Validated; Region: PRK00228
331113002417	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
331113002418	mce related protein; Region: MCE; pfam02470
331113002419	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
331113002420	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331113002421	Walker A/P-loop; other site
331113002422	ATP binding site [chemical binding]; other site
331113002423	Q-loop/lid; other site
331113002424	ABC transporter signature motif; other site
331113002425	Walker B; other site
331113002426	D-loop; other site
331113002427	H-loop/switch region; other site
331113002428	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
331113002429	Permease; Region: Permease; pfam02405
331113002430	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
331113002431	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331113002432	binding surface
331113002433	Tetratricopeptide repeat; Region: TPR_16; pfam13432
331113002434	TPR motif; other site
331113002435	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
331113002436	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
331113002437	inhibitor-cofactor binding pocket; inhibition site
331113002438	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331113002439	catalytic residue [active]
331113002440	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
331113002441	active site residues [active]
331113002442	dimer interface [polypeptide binding]; other site
331113002443	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
331113002444	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
331113002445	hypothetical protein; Provisional; Region: PRK13665
331113002446	Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784
331113002447	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
331113002448	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
331113002449	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331113002450	enoyl-[acyl-carrier-protein] reductase; Region: PLN02730
331113002451	NAD(P) binding site [chemical binding]; other site
331113002452	active site
331113002453	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
331113002454	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
331113002455	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
331113002456	conserved cys residue [active]
331113002457	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
331113002458	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
331113002459	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
331113002460	putative SAM binding site [chemical binding]; other site
331113002461	homodimer interface [polypeptide binding]; other site
331113002462	methionine sulfoxide reductase B; Provisional; Region: PRK00222
331113002463	SelR domain; Region: SelR; pfam01641
331113002464	coproporphyrinogen III oxidase; Provisional; Region: PRK06294
331113002465	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331113002466	FeS/SAM binding site; other site
331113002467	HemN C-terminal domain; Region: HemN_C; pfam06969
331113002468	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
331113002469	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
331113002470	TPP-binding site [chemical binding]; other site
331113002471	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
331113002472	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
331113002473	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
331113002474	E3 interaction surface; other site
331113002475	lipoyl attachment site [posttranslational modification]; other site
331113002476	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
331113002477	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
331113002478	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
331113002479	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331113002480	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
331113002481	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
331113002482	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331113002483	catalytic loop [active]
331113002484	iron binding site [ion binding]; other site
331113002485	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
331113002486	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
331113002487	adenylate kinase; Region: adk; TIGR01351
331113002488	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
331113002489	AMP-binding site [chemical binding]; other site
331113002490	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
331113002491	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
331113002492	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
331113002493	active site
331113002494	Int/Topo IB signature motif; other site
331113002495	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
331113002496	Protein export membrane protein; Region: SecD_SecF; cl14618
331113002497	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
331113002498	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331113002499	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
331113002500	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
331113002501	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
331113002502	GatB domain; Region: GatB_Yqey; smart00845
331113002503	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
331113002504	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
331113002505	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
331113002506	Domain of unknown function (DUF378); Region: DUF378; pfam04070
331113002507	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
331113002508	hydrophobic ligand binding site; other site
331113002509	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
331113002510	TIGR01777 family protein; Region: yfcH
331113002511	putative NAD(P) binding site [chemical binding]; other site
331113002512	putative active site [active]
331113002513	Ras GTPase Activating Domain; Region: RasGAP; cl02569
331113002514	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
331113002515	putative MFS family transporter protein; Provisional; Region: PRK03633
331113002516	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113002517	putative substrate translocation pore; other site
331113002518	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
331113002519	homotrimer interaction site [polypeptide binding]; other site
331113002520	putative active site [active]
331113002521	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
331113002522	active site
331113002523	catalytic residues [active]
331113002524	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
331113002525	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
331113002526	Walker A/P-loop; other site
331113002527	ATP binding site [chemical binding]; other site
331113002528	Q-loop/lid; other site
331113002529	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
331113002530	ABC transporter signature motif; other site
331113002531	Walker B; other site
331113002532	D-loop; other site
331113002533	H-loop/switch region; other site
331113002534	ribonuclease HIII; Provisional; Region: PRK00996
331113002535	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
331113002536	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
331113002537	RNA/DNA hybrid binding site [nucleotide binding]; other site
331113002538	active site
331113002539	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
331113002540	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331113002541	non-specific DNA binding site [nucleotide binding]; other site
331113002542	salt bridge; other site
331113002543	sequence-specific DNA binding site [nucleotide binding]; other site
331113002544	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
331113002545	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
331113002546	catalytic residues [active]
331113002547	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
331113002548	Catalytic domain of Protein Kinases; Region: PKc; cd00180
331113002549	active site
331113002550	ATP binding site [chemical binding]; other site
331113002551	substrate binding site [chemical binding]; other site
331113002552	activation loop (A-loop); other site
331113002553	Uncharacterized conserved protein [Function unknown]; Region: COG1262
331113002554	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
331113002555	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
331113002556	Low molecular weight phosphatase family; Region: LMWPc; cd00115
331113002557	active site
331113002558	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
331113002559	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
331113002560	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
331113002561	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
331113002562	Ligand Binding Site [chemical binding]; other site
331113002563	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
331113002564	nudix motif; other site
331113002565	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
331113002566	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
331113002567	Walker A/P-loop; other site
331113002568	ATP binding site [chemical binding]; other site
331113002569	Q-loop/lid; other site
331113002570	ABC transporter signature motif; other site
331113002571	Walker B; other site
331113002572	D-loop; other site
331113002573	H-loop/switch region; other site
331113002574	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
331113002575	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
331113002576	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
331113002577	Walker A/P-loop; other site
331113002578	ATP binding site [chemical binding]; other site
331113002579	Q-loop/lid; other site
331113002580	ABC transporter signature motif; other site
331113002581	Walker B; other site
331113002582	D-loop; other site
331113002583	H-loop/switch region; other site
331113002584	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
331113002585	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
331113002586	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
331113002587	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331113002588	dimer interface [polypeptide binding]; other site
331113002589	conserved gate region; other site
331113002590	putative PBP binding loops; other site
331113002591	ABC-ATPase subunit interface; other site
331113002592	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
331113002593	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331113002594	dimer interface [polypeptide binding]; other site
331113002595	conserved gate region; other site
331113002596	putative PBP binding loops; other site
331113002597	ABC-ATPase subunit interface; other site
331113002598	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
331113002599	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
331113002600	putative active site; other site
331113002601	catalytic residue [active]
331113002602	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
331113002603	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
331113002604	dimer interface [polypeptide binding]; other site
331113002605	ADP-ribose binding site [chemical binding]; other site
331113002606	active site
331113002607	nudix motif; other site
331113002608	metal binding site [ion binding]; metal-binding site
331113002609	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
331113002610	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331113002611	dimerization interface [polypeptide binding]; other site
331113002612	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
331113002613	cyclase homology domain; Region: CHD; cd07302
331113002614	nucleotidyl binding site; other site
331113002615	metal binding site [ion binding]; metal-binding site
331113002616	dimer interface [polypeptide binding]; other site
331113002617	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
331113002618	Fe-S cluster binding site [ion binding]; other site
331113002619	DNA binding site [nucleotide binding]
331113002620	active site
331113002621	PspC domain; Region: PspC; pfam04024
331113002622	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
331113002623	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
331113002624	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
331113002625	RNA binding surface [nucleotide binding]; other site
331113002626	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
331113002627	active site
331113002628	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
331113002629	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
331113002630	putative dimer interface [polypeptide binding]; other site
331113002631	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
331113002632	intracellular protease, PfpI family; Region: PfpI; TIGR01382
331113002633	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
331113002634	proposed catalytic triad [active]
331113002635	conserved cys residue [active]
331113002636	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
331113002637	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
331113002638	Glutaredoxin; Region: Glutaredoxin; pfam00462
331113002639	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
331113002640	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
331113002641	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
331113002642	Tetramer interface [polypeptide binding]; other site
331113002643	active site
331113002644	FMN-binding site [chemical binding]; other site
331113002645	shikimate kinase; Reviewed; Region: aroK; PRK00131
331113002646	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
331113002647	ADP binding site [chemical binding]; other site
331113002648	magnesium binding site [ion binding]; other site
331113002649	putative shikimate binding site; other site
331113002650	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
331113002651	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
331113002652	hinge; other site
331113002653	active site
331113002654	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
331113002655	active site
331113002656	dimer interface [polypeptide binding]; other site
331113002657	metal binding site [ion binding]; metal-binding site
331113002658	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
331113002659	Prephenate dehydratase; Region: PDT; pfam00800
331113002660	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
331113002661	Chorismate mutase type II; Region: CM_2; smart00830
331113002662	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
331113002663	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
331113002664	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
331113002665	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
331113002666	homodimer interface [polypeptide binding]; other site
331113002667	substrate-cofactor binding pocket; other site
331113002668	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331113002669	catalytic residue [active]
331113002670	prephenate dehydrogenase; Validated; Region: PRK08507
331113002671	bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310
331113002672	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
331113002673	active site
331113002674	catalytic residue [active]
331113002675	dimer interface [polypeptide binding]; other site
331113002676	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
331113002677	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
331113002678	shikimate binding site; other site
331113002679	NAD(P) binding site [chemical binding]; other site
331113002680	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
331113002681	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
331113002682	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
331113002683	transmembrane helices; other site
331113002684	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
331113002685	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113002686	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
331113002687	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113002688	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113002689	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113002690	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113002691	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113002692	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113002693	FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666
331113002694	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113002695	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
331113002696	hypothetical protein; Reviewed; Region: PRK09588
331113002697	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
331113002698	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
331113002699	metal binding site [ion binding]; metal-binding site
331113002700	aconitate hydratase; Validated; Region: PRK07229
331113002701	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
331113002702	substrate binding site [chemical binding]; other site
331113002703	ligand binding site [chemical binding]; other site
331113002704	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
331113002705	substrate binding site [chemical binding]; other site
331113002706	Membrane protein of unknown function; Region: DUF360; pfam04020
331113002707	Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553
331113002708	active site
331113002709	Ubiquitin carboxyl-terminal hydrolase; Region: UCH; pfam00443
331113002710	Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553
331113002711	active site
331113002712	Opioid growth factor receptor (OGFr) conserved region; Region: OGFr_N; pfam04664
331113002713	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331113002714	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
331113002715	active site
331113002716	Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346
331113002717	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331113002718	active site
331113002719	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
331113002720	active site
331113002721	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
331113002722	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
331113002723	dimer interface [polypeptide binding]; other site
331113002724	catalytic triad [active]
331113002725	peroxidatic and resolving cysteines [active]
331113002726	malate dehydrogenase; Provisional; Region: PRK13529
331113002727	Malic enzyme, N-terminal domain; Region: malic; pfam00390
331113002728	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
331113002729	NAD(P) binding site [chemical binding]; other site
331113002730	TLC ATP/ADP transporter; Region: TLC; cl03940
331113002731	Peptidase family M48; Region: Peptidase_M48; pfam01435
331113002732	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
331113002733	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
331113002734	Zn2+ binding site [ion binding]; other site
331113002735	Mg2+ binding site [ion binding]; other site
331113002736	arginine:agmatin antiporter; Provisional; Region: PRK10644
331113002737	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
331113002738	Spore germination protein; Region: Spore_permease; cl17796
331113002739	arginine:agmatin antiporter; Provisional; Region: PRK10644
331113002740	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843
331113002741	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
331113002742	active site
331113002743	Fic/DOC family; Region: Fic; pfam02661
331113002744	Fic/DOC family; Region: Fic; pfam02661
331113002745	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
331113002746	putative metal binding site; other site
331113002747	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
331113002748	putative active site [active]
331113002749	putative metal binding site [ion binding]; other site
331113002750	Ubiquitin carboxyl-terminal hydrolase; Region: UCH; pfam00443
331113002751	Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553
331113002752	active site
331113002753	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
331113002754	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; pfam08273
331113002755	DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358
331113002756	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
331113002757	active site
331113002758	metal binding site [ion binding]; metal-binding site
331113002759	interdomain interaction site; other site
331113002760	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
331113002761	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
331113002762	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
331113002763	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
331113002764	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
331113002765	active site
331113002766	DNA binding site [nucleotide binding]
331113002767	Int/Topo IB signature motif; other site
331113002768	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
331113002769	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
331113002770	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
331113002771	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
331113002772	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
331113002773	HIGH motif; other site
331113002774	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
331113002775	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
331113002776	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
331113002777	active site
331113002778	KMSKS motif; other site
331113002779	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
331113002780	tRNA binding surface [nucleotide binding]; other site
331113002781	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
331113002782	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
331113002783	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
331113002784	SmpB-tmRNA interface; other site
331113002785	DNA polymerase III subunit beta; Validated; Region: PRK05643
331113002786	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
331113002787	putative DNA binding surface [nucleotide binding]; other site
331113002788	dimer interface [polypeptide binding]; other site
331113002789	beta-clamp/clamp loader binding surface; other site
331113002790	beta-clamp/translesion DNA polymerase binding surface; other site
331113002791	recombination protein F; Reviewed; Region: recF; PRK00064
331113002792	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
331113002793	Walker A/P-loop; other site
331113002794	ATP binding site [chemical binding]; other site
331113002795	Q-loop/lid; other site
331113002796	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331113002797	ABC transporter signature motif; other site
331113002798	Walker B; other site
331113002799	D-loop; other site
331113002800	Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119
331113002801	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
331113002802	EamA-like transporter family; Region: EamA; pfam00892
331113002803	EamA-like transporter family; Region: EamA; pfam00892
331113002804	EamA-like transporter family; Region: EamA; pfam00892
331113002805	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
331113002806	EamA-like transporter family; Region: EamA; pfam00892
331113002807	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113002808	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113002809	putative substrate translocation pore; other site
331113002810	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095
331113002811	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
331113002812	active site
331113002813	dimer interface [polypeptide binding]; other site
331113002814	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
331113002815	dimer interface [polypeptide binding]; other site
331113002816	active site
331113002817	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
331113002818	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331113002819	Walker A/P-loop; other site
331113002820	ATP binding site [chemical binding]; other site
331113002821	Q-loop/lid; other site
331113002822	ABC transporter signature motif; other site
331113002823	Walker B; other site
331113002824	D-loop; other site
331113002825	H-loop/switch region; other site
331113002826	ABC transporter; Region: ABC_tran_2; pfam12848
331113002827	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
331113002828	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
331113002829	putative catalytic site [active]
331113002830	putative phosphate binding site [ion binding]; other site
331113002831	putative metal binding site [ion binding]; other site
331113002832	AAA domain; Region: AAA_14; pfam13173
331113002833	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
331113002834	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
331113002835	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
331113002836	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
331113002837	active site
331113002838	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
331113002839	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331113002840	motif II; other site
331113002841	FAD binding domain; Region: FAD_binding_3; pfam01494
331113002842	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
331113002843	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
331113002844	NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797
331113002845	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
331113002846	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331113002847	Walker A/P-loop; other site
331113002848	ATP binding site [chemical binding]; other site
331113002849	Q-loop/lid; other site
331113002850	ABC transporter signature motif; other site
331113002851	Walker B; other site
331113002852	D-loop; other site
331113002853	H-loop/switch region; other site
331113002854	NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796
331113002855	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
331113002856	putative active site [active]
331113002857	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
331113002858	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331113002859	Walker A/P-loop; other site
331113002860	ATP binding site [chemical binding]; other site
331113002861	Q-loop/lid; other site
331113002862	ABC transporter signature motif; other site
331113002863	Walker B; other site
331113002864	D-loop; other site
331113002865	H-loop/switch region; other site
331113002866	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
331113002867	carboxyltransferase (CT) interaction site; other site
331113002868	biotinylation site [posttranslational modification]; other site
331113002869	HlyD family secretion protein; Region: HlyD_3; pfam13437
331113002870	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
331113002871	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
331113002872	nucleotide binding site [chemical binding]; other site
331113002873	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
331113002874	putative phosphoketolase; Provisional; Region: PRK05261
331113002875	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
331113002876	TPP-binding site; other site
331113002877	Src homology 3 domains; Region: SH3; smart00326
331113002878	peptide ligand binding site [polypeptide binding]; other site
331113002879	XFP C-terminal domain; Region: XFP_C; pfam09363
331113002880	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
331113002881	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
331113002882	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
331113002883	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331113002884	motif II; other site
331113002885	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
331113002886	RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably...; Region: RING; cd00162
331113002887	cross-brace motif; other site
331113002888	Fic/DOC family; Region: Fic; pfam02661
331113002889	Fic/DOC family; Region: Fic; pfam02661
331113002890	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
331113002891	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
331113002892	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
331113002893	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
331113002894	TLC ATP/ADP transporter; Region: TLC; cl03940
331113002895	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
331113002896	A new structural DNA glycosylase; Region: AlkD_like; cd06561
331113002897	active site
331113002898	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137
331113002899	reactive center loop; other site
331113002900	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
331113002901	putative substrate binding site 2 [chemical binding]; other site
331113002902	putative substrate binding site 1 [chemical binding]; other site
331113002903	Na binding site 1 [ion binding]; other site
331113002904	Na2 binding site [ion binding]; other site
331113002905	Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852
331113002906	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
331113002907	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
331113002908	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
331113002909	Sulfatase; Region: Sulfatase; pfam00884
331113002910	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
331113002911	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
331113002912	Catalytic site [active]
331113002913	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
331113002914	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
331113002915	active site
331113002916	DNA binding site [nucleotide binding]
331113002917	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
331113002918	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
331113002919	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
331113002920	dimerization interface [polypeptide binding]; other site
331113002921	ligand binding site [chemical binding]; other site
331113002922	NADP binding site [chemical binding]; other site
331113002923	catalytic site [active]
331113002924	Beta-lactamase; Region: Beta-lactamase; pfam00144
331113002925	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
331113002926	PPR repeat family; Region: PPR_2; pfam13041
331113002927	pentatricopeptide repeat domain (PPR motif); Region: PPR; TIGR00756
331113002928	PPR repeat family; Region: PPR_2; pfam13041
331113002929	PPR repeat; Region: PPR; cl03252
331113002930	FOG: CBS domain [General function prediction only]; Region: COG0517
331113002931	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
331113002932	Divalent cation transporter; Region: MgtE; cl00786
331113002933	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113002934	S-adenosylmethionine binding site [chemical binding]; other site
331113002935	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
331113002936	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
331113002937	glutaminase active site [active]
331113002938	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
331113002939	dimer interface [polypeptide binding]; other site
331113002940	active site
331113002941	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
331113002942	dimer interface [polypeptide binding]; other site
331113002943	active site
331113002944	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
331113002945	Na binding site [ion binding]; other site
331113002946	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331113002947	non-specific DNA binding site [nucleotide binding]; other site
331113002948	salt bridge; other site
331113002949	sequence-specific DNA binding site [nucleotide binding]; other site
331113002950	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
331113002951	EamA-like transporter family; Region: EamA; pfam00892
331113002952	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
331113002953	EamA-like transporter family; Region: EamA; pfam00892
331113002954	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113002955	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113002956	putative substrate translocation pore; other site
331113002957	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113002958	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113002959	putative substrate translocation pore; other site
331113002960	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
331113002961	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
331113002962	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
331113002963	Ligand Binding Site [chemical binding]; other site
331113002964	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
331113002965	Sel1-like repeats; Region: SEL1; smart00671
331113002966	Sel1 repeat; Region: Sel1; cl02723
331113002967	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
331113002968	MviN-like protein; Region: MVIN; pfam03023
331113002969	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
331113002970	Beta-lactamase; Region: Beta-lactamase; pfam00144
331113002971	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
331113002972	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
331113002973	Fic family protein [Function unknown]; Region: COG3177
331113002974	Fic/DOC family; Region: Fic; pfam02661
331113002975	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
331113002976	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
331113002977	amphipathic channel; other site
331113002978	Asn-Pro-Ala signature motifs; other site
331113002979	glycerol kinase; Provisional; Region: glpK; PRK00047
331113002980	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
331113002981	N- and C-terminal domain interface [polypeptide binding]; other site
331113002982	active site
331113002983	MgATP binding site [chemical binding]; other site
331113002984	catalytic site [active]
331113002985	metal binding site [ion binding]; metal-binding site
331113002986	glycerol binding site [chemical binding]; other site
331113002987	homotetramer interface [polypeptide binding]; other site
331113002988	homodimer interface [polypeptide binding]; other site
331113002989	FBP binding site [chemical binding]; other site
331113002990	protein IIAGlc interface [polypeptide binding]; other site
331113002991	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
331113002992	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
331113002993	GIY-YIG motif/motif A; other site
331113002994	GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541
331113002995	active site
331113002996	catalytic site [active]
331113002997	metal binding site [ion binding]; metal-binding site
331113002998	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
331113002999	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
331113003000	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
331113003001	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
331113003002	C factor cell-cell signaling protein; Provisional; Region: PRK09009
331113003003	NADP binding site [chemical binding]; other site
331113003004	homodimer interface [polypeptide binding]; other site
331113003005	active site
331113003006	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113003007	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113003008	putative substrate translocation pore; other site
331113003009	ferrochelatase; Reviewed; Region: hemH; PRK00035
331113003010	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
331113003011	C-terminal domain interface [polypeptide binding]; other site
331113003012	active site
331113003013	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
331113003014	active site
331113003015	N-terminal domain interface [polypeptide binding]; other site
331113003016	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113003017	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113003018	putative substrate translocation pore; other site
331113003019	FOG: CBS domain [General function prediction only]; Region: COG0517
331113003020	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
331113003021	Ion channel; Region: Ion_trans_2; pfam07885
331113003022	Hemerythrin-like domain of FBXL5-like proteins; Region: Hr_FBXL5; cd12109
331113003023	Fe binding site [ion binding]; other site
331113003024	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331113003025	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331113003026	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
331113003027	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
331113003028	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
331113003029	dimer interface [polypeptide binding]; other site
331113003030	motif 1; other site
331113003031	active site
331113003032	motif 2; other site
331113003033	motif 3; other site
331113003034	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
331113003035	23S rRNA binding site [nucleotide binding]; other site
331113003036	L21 binding site [polypeptide binding]; other site
331113003037	L13 binding site [polypeptide binding]; other site
331113003038	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
331113003039	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
331113003040	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
331113003041	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
331113003042	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
331113003043	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
331113003044	motif 2; other site
331113003045	L-aspartate oxidase; Provisional; Region: PRK09077
331113003046	L-aspartate oxidase; Provisional; Region: PRK06175
331113003047	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
331113003048	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113003049	S-adenosylmethionine binding site [chemical binding]; other site
331113003050	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
331113003051	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
331113003052	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
331113003053	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
331113003054	active site
331113003055	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
331113003056	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
331113003057	FAD binding domain; Region: FAD_binding_4; pfam01565
331113003058	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
331113003059	transcription antitermination factor NusB; Region: nusB; TIGR01951
331113003060	putative RNA binding site [nucleotide binding]; other site
331113003061	MgtC family; Region: MgtC; pfam02308
331113003062	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
331113003063	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
331113003064	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
331113003065	dimerization interface [polypeptide binding]; other site
331113003066	DPS ferroxidase diiron center [ion binding]; other site
331113003067	ion pore; other site
331113003068	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
331113003069	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
331113003070	active site
331113003071	catalytic site [active]
331113003072	substrate binding site [chemical binding]; other site
331113003073	Cupin domain; Region: Cupin_2; pfam07883
331113003074	Methyltransferase domain; Region: Methyltransf_31; pfam13847
331113003075	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113003076	S-adenosylmethionine binding site [chemical binding]; other site
331113003077	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113003078	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
331113003079	Walker A motif; other site
331113003080	ATP binding site [chemical binding]; other site
331113003081	DNA polymerase III subunit delta'; Validated; Region: PRK08485
331113003082	Walker B motif; other site
331113003083	arginine finger; other site
331113003084	thymidylate kinase; Validated; Region: tmk; PRK00698
331113003085	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
331113003086	TMP-binding site; other site
331113003087	ATP-binding site [chemical binding]; other site
331113003088	DNA gyrase subunit A; Validated; Region: PRK05560
331113003089	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
331113003090	CAP-like domain; other site
331113003091	active site
331113003092	primary dimer interface [polypeptide binding]; other site
331113003093	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
331113003094	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
331113003095	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
331113003096	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
331113003097	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
331113003098	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
331113003099	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
331113003100	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331113003101	ATP binding site [chemical binding]; other site
331113003102	Mg2+ binding site [ion binding]; other site
331113003103	G-X-G motif; other site
331113003104	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
331113003105	anchoring element; other site
331113003106	dimer interface [polypeptide binding]; other site
331113003107	ATP binding site [chemical binding]; other site
331113003108	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
331113003109	active site
331113003110	putative metal-binding site [ion binding]; other site
331113003111	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
331113003112	Protein of unknown function (DUF721); Region: DUF721; pfam05258
331113003113	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
331113003114	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
331113003115	G1 box; other site
331113003116	putative GEF interaction site [polypeptide binding]; other site
331113003117	GTP/Mg2+ binding site [chemical binding]; other site
331113003118	Switch I region; other site
331113003119	G2 box; other site
331113003120	G3 box; other site
331113003121	Switch II region; other site
331113003122	G4 box; other site
331113003123	G5 box; other site
331113003124	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
331113003125	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
331113003126	Penicillinase repressor; Region: Pencillinase_R; cl17580
331113003127	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
331113003128	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
331113003129	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113003130	S-adenosylmethionine binding site [chemical binding]; other site
331113003131	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
331113003132	chorismate binding enzyme; Region: Chorismate_bind; cl10555
331113003133	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
331113003134	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
331113003135	dimer interface [polypeptide binding]; other site
331113003136	tetramer interface [polypeptide binding]; other site
331113003137	PYR/PP interface [polypeptide binding]; other site
331113003138	TPP binding site [chemical binding]; other site
331113003139	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
331113003140	TPP-binding site; other site
331113003141	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
331113003142	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331113003143	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
331113003144	substrate binding site [chemical binding]; other site
331113003145	oxyanion hole (OAH) forming residues; other site
331113003146	trimer interface [polypeptide binding]; other site
331113003147	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
331113003148	UbiA prenyltransferase family; Region: UbiA; pfam01040
331113003149	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
331113003150	active site
331113003151	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
331113003152	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
331113003153	acyl-activating enzyme (AAE) consensus motif; other site
331113003154	putative active site [active]
331113003155	putative AMP binding site [chemical binding]; other site
331113003156	putative CoA binding site [chemical binding]; other site
331113003157	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
331113003158	active site
331113003159	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331113003160	binding surface
331113003161	TPR motif; other site
331113003162	TPR repeat; Region: TPR_11; pfam13414
331113003163	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331113003164	TPR motif; other site
331113003165	binding surface
331113003166	putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001
331113003167	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
331113003168	chromosomal replication initiation protein; Provisional; Region: PRK12422
331113003169	DnaA N-terminal domain; Region: DnaA_N; pfam11638
331113003170	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113003171	Walker A motif; other site
331113003172	ATP binding site [chemical binding]; other site
331113003173	Walker B motif; other site
331113003174	arginine finger; other site
331113003175	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
331113003176	DnaA box-binding interface [nucleotide binding]; other site
331113003177	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113003178	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113003179	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113003180	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113003181	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113003182	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113003183	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
331113003184	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
331113003185	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
331113003186	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
331113003187	active site
331113003188	catalytic site [active]
331113003189	CAAX protease self-immunity; Region: Abi; pfam02517
331113003190	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172
331113003191	reactive center loop; other site
331113003192	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
331113003193	Protein phosphatase 2C; Region: PP2C; pfam00481
331113003194	active site
331113003195	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
331113003196	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
331113003197	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331113003198	catalytic residue [active]
331113003199	amphi-Trp domain; Region: amphi-Trp; TIGR04354
331113003200	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
331113003201	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
331113003202	substrate binding pocket [chemical binding]; other site
331113003203	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
331113003204	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
331113003205	Domain of unknown function DUF21; Region: DUF21; pfam01595
331113003206	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
331113003207	Transporter associated domain; Region: CorC_HlyC; smart01091
331113003208	Domain of unknown function DUF21; Region: DUF21; pfam01595
331113003209	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
331113003210	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
331113003211	Transporter associated domain; Region: CorC_HlyC; pfam03471
331113003212	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
331113003213	trimer interface [polypeptide binding]; other site
331113003214	active site
331113003215	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
331113003216	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113003217	Walker A motif; other site
331113003218	ATP binding site [chemical binding]; other site
331113003219	Walker B motif; other site
331113003220	arginine finger; other site
331113003221	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
331113003222	Stage II sporulation protein; Region: SpoIID; pfam08486
331113003223	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
331113003224	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
331113003225	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
331113003226	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
331113003227	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113003228	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113003229	putative substrate translocation pore; other site
331113003230	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
331113003231	active site
331113003232	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
331113003233	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
331113003234	active site
331113003235	HIGH motif; other site
331113003236	dimer interface [polypeptide binding]; other site
331113003237	KMSKS motif; other site
331113003238	serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184
331113003239	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
331113003240	active site
331113003241	ATP binding site [chemical binding]; other site
331113003242	substrate binding site [chemical binding]; other site
331113003243	activation loop (A-loop); other site
331113003244	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
331113003245	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
331113003246	active site
331113003247	HIGH motif; other site
331113003248	nucleotide binding site [chemical binding]; other site
331113003249	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
331113003250	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
331113003251	active site
331113003252	KMSKS motif; other site
331113003253	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
331113003254	tRNA binding surface [nucleotide binding]; other site
331113003255	anticodon binding site; other site
331113003256	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
331113003257	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003258	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003259	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003260	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003261	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003262	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003263	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003264	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003265	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003266	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003267	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003268	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003269	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003270	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003271	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003272	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003273	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003274	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003275	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003276	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003277	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113003278	Autotransporter beta-domain; Region: Autotransporter; pfam03797
331113003279	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
331113003280	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
331113003281	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
331113003282	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331113003283	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
331113003284	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
331113003285	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
331113003286	amino acid carrier protein; Region: agcS; TIGR00835
331113003287	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
331113003288	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
331113003289	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
331113003290	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113003291	putative substrate translocation pore; other site
331113003292	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
331113003293	nudix motif; other site
331113003294	fumarate hydratase; Reviewed; Region: fumC; PRK00485
331113003295	Class II fumarases; Region: Fumarase_classII; cd01362
331113003296	active site
331113003297	tetramer interface [polypeptide binding]; other site
331113003298	Autotransporter beta-domain; Region: Autotransporter; cl17461
331113003299	V-type ATP synthase subunit K; Provisional; Region: PRK09621
331113003300	F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K [Energy production and conversion]; Region: AtpE; COG0636
331113003301	V-type ATP synthase subunit I; Validated; Region: PRK05771
331113003302	V-type ATP synthase subunit D; Provisional; Region: PRK02195
331113003303	V-type ATP synthase subunit B; Provisional; Region: PRK02118
331113003304	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
331113003305	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
331113003306	Walker A motif homologous position; other site
331113003307	Walker B motif; other site
331113003308	V-type ATP synthase subunit A; Provisional; Region: PRK04192
331113003309	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
331113003310	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
331113003311	Walker A motif/ATP binding site; other site
331113003312	Walker B motif; other site
331113003313	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
331113003314	Protein of unknown function (DUF2764); Region: DUF2764; pfam10962
331113003315	V-type ATP synthase subunit E; Provisional; Region: PRK01005
331113003316	V-type ATP synthase subunit E; Provisional; Region: PRK01558
331113003317	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
331113003318	transaldolase-like protein; Provisional; Region: PTZ00411
331113003319	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
331113003320	active site
331113003321	dimer interface [polypeptide binding]; other site
331113003322	catalytic residue [active]
331113003323	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
331113003324	L11 interface [polypeptide binding]; other site
331113003325	putative EF-G interaction site [polypeptide binding]; other site
331113003326	putative EF-Tu interaction site [polypeptide binding]; other site
331113003327	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
331113003328	G3 box; other site
331113003329	Switch II region; other site
331113003330	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
331113003331	Formamidopyrimidine-DNA glycosylase N-terminal domain; Region: Fapy_DNA_glyco; pfam01149
331113003332	DNA binding site [nucleotide binding]
331113003333	catalytic residue [active]
331113003334	H2TH interface [polypeptide binding]; other site
331113003335	putative catalytic residues [active]
331113003336	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
331113003337	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
331113003338	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
331113003339	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
331113003340	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
331113003341	cyclase homology domain; Region: CHD; cd07302
331113003342	nucleotidyl binding site; other site
331113003343	metal binding site [ion binding]; metal-binding site
331113003344	dimer interface [polypeptide binding]; other site
331113003345	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
331113003346	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331113003347	Methyltransferase domain; Region: Methyltransf_31; pfam13847
331113003348	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113003349	S-adenosylmethionine binding site [chemical binding]; other site
331113003350	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
331113003351	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
331113003352	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
331113003353	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
331113003354	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
331113003355	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
331113003356	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
331113003357	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
331113003358	DNA binding site [nucleotide binding]
331113003359	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
331113003360	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563
331113003361	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
331113003362	DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013
331113003363	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
331113003364	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
331113003365	RPB11 interaction site [polypeptide binding]; other site
331113003366	RPB12 interaction site [polypeptide binding]; other site
331113003367	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
331113003368	RPB12 interaction site [polypeptide binding]; other site
331113003369	RPB3 interaction site [polypeptide binding]; other site
331113003370	RPB1 interaction site [polypeptide binding]; other site
331113003371	RPB11 interaction site [polypeptide binding]; other site
331113003372	RPB10 interaction site [polypeptide binding]; other site
331113003373	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
331113003374	core dimer interface [polypeptide binding]; other site
331113003375	peripheral dimer interface [polypeptide binding]; other site
331113003376	L10 interface [polypeptide binding]; other site
331113003377	L11 interface [polypeptide binding]; other site
331113003378	putative EF-Tu interaction site [polypeptide binding]; other site
331113003379	putative EF-G interaction site [polypeptide binding]; other site
331113003380	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
331113003381	23S rRNA interface [nucleotide binding]; other site
331113003382	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
331113003383	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
331113003384	mRNA/rRNA interface [nucleotide binding]; other site
331113003385	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
331113003386	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
331113003387	23S rRNA interface [nucleotide binding]; other site
331113003388	L7/L12 interface [polypeptide binding]; other site
331113003389	putative thiostrepton binding site; other site
331113003390	L25 interface [polypeptide binding]; other site
331113003391	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
331113003392	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
331113003393	putative homodimer interface [polypeptide binding]; other site
331113003394	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
331113003395	heterodimer interface [polypeptide binding]; other site
331113003396	homodimer interface [polypeptide binding]; other site
331113003397	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
331113003398	elongation factor Tu; Reviewed; Region: PRK00049
331113003399	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
331113003400	G1 box; other site
331113003401	GEF interaction site [polypeptide binding]; other site
331113003402	GTP/Mg2+ binding site [chemical binding]; other site
331113003403	Switch I region; other site
331113003404	G2 box; other site
331113003405	G3 box; other site
331113003406	Switch II region; other site
331113003407	G4 box; other site
331113003408	G5 box; other site
331113003409	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
331113003410	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
331113003411	Antibiotic Binding Site [chemical binding]; other site
331113003412	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
331113003413	rRNA binding site [nucleotide binding]; other site
331113003414	predicted 30S ribosome binding site; other site
331113003415	Fe-S metabolism associated domain; Region: SufE; cl00951
331113003416	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
331113003417	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
331113003418	active site
331113003419	HEAT repeats; Region: HEAT_2; pfam13646
331113003420	HEAT repeats; Region: HEAT_2; pfam13646
331113003421	HEAT repeats; Region: HEAT_2; pfam13646
331113003422	HEAT repeats; Region: HEAT_2; pfam13646
331113003423	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
331113003424	nucleotide binding site/active site [active]
331113003425	HIT family signature motif; other site
331113003426	catalytic residue [active]
331113003427	Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690
331113003428	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
331113003429	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
331113003430	aromatic amino acid transport protein; Region: araaP; TIGR00837
331113003431	Protein of unknown function (DUF1207); Region: DUF1207; pfam06727
331113003432	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113003433	S-adenosylmethionine binding site [chemical binding]; other site
331113003434	D-galactonate transporter; Region: 2A0114; TIGR00893
331113003435	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113003436	putative substrate translocation pore; other site
331113003437	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113003438	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
331113003439	putative substrate translocation pore; other site
331113003440	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113003441	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113003442	putative substrate translocation pore; other site
331113003443	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113003444	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113003445	putative substrate translocation pore; other site
331113003446	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113003447	putative substrate translocation pore; other site
331113003448	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113003449	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113003450	D-galactonate transporter; Region: 2A0114; TIGR00893
331113003451	putative substrate translocation pore; other site
331113003452	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
331113003453	catalytic core [active]
331113003454	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
331113003455	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
331113003456	Ligand binding site; other site
331113003457	oligomer interface; other site
331113003458	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
331113003459	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
331113003460	inhibitor site; inhibition site
331113003461	active site
331113003462	dimer interface [polypeptide binding]; other site
331113003463	catalytic residue [active]
331113003464	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
331113003465	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
331113003466	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
331113003467	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
331113003468	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
331113003469	Walker A/P-loop; other site
331113003470	ATP binding site [chemical binding]; other site
331113003471	Q-loop/lid; other site
331113003472	ABC transporter signature motif; other site
331113003473	Walker B; other site
331113003474	D-loop; other site
331113003475	H-loop/switch region; other site
331113003476	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331113003477	Coenzyme A binding pocket [chemical binding]; other site
331113003478	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
331113003479	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331113003480	Coenzyme A binding pocket [chemical binding]; other site
331113003481	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
331113003482	FAD binding domain; Region: FAD_binding_4; pfam01565
331113003483	Methyltransferase domain; Region: Methyltransf_23; pfam13489
331113003484	Methyltransferase domain; Region: Methyltransf_11; pfam08241
331113003485	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331113003486	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
331113003487	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
331113003488	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
331113003489	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
331113003490	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
331113003491	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331113003492	catalytic residue [active]
331113003493	hypothetical protein; Provisional; Region: PRK02268
331113003494	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
331113003495	metal binding triad [ion binding]; metal-binding site
331113003496	Protein of unknown function (DUF1706); Region: DUF1706; cl01748
331113003497	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
331113003498	nudix motif; other site
331113003499	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331113003500	PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750
331113003501	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331113003502	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113003503	putative substrate translocation pore; other site
331113003504	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113003505	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
331113003506	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331113003507	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
331113003508	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113003509	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113003510	putative substrate translocation pore; other site
331113003511	CAAX protease self-immunity; Region: Abi; pfam02517
331113003512	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
331113003513	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
331113003514	aromatic amino acid transport protein; Region: araaP; TIGR00837
331113003515	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
331113003516	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331113003517	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113003518	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113003519	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
331113003520	HlyD family secretion protein; Region: HlyD_3; pfam13437
331113003521	Outer membrane efflux protein; Region: OEP; pfam02321
331113003522	Outer membrane efflux protein; Region: OEP; pfam02321
331113003523	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
331113003524	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113003525	Walker A motif; other site
331113003526	ATP binding site [chemical binding]; other site
331113003527	Walker B motif; other site
331113003528	arginine finger; other site
331113003529	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
331113003530	Isochorismatase family; Region: Isochorismatase; pfam00857
331113003531	catalytic triad [active]
331113003532	metal binding site [ion binding]; metal-binding site
331113003533	conserved cis-peptide bond; other site
331113003534	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
331113003535	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
331113003536	active site
331113003537	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); Region: PCMT; pfam01135
331113003538	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113003539	S-adenosylmethionine binding site [chemical binding]; other site
331113003540	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
331113003541	Uncharacterized conserved protein [Function unknown]; Region: COG2128
331113003542	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
331113003543	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
331113003544	Catalytic site [active]
331113003545	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
331113003546	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
331113003547	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
331113003548	dimer interface [polypeptide binding]; other site
331113003549	catalytic triad [active]
331113003550	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
331113003551	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
331113003552	HIGH motif; other site
331113003553	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
331113003554	active site
331113003555	KMSKS motif; other site
331113003556	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
331113003557	tRNA binding surface [nucleotide binding]; other site
331113003558	anticodon binding site; other site
331113003559	FOG: WD40 repeat [General function prediction only]; Region: COG2319
331113003560	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
331113003561	structural tetrad; other site
331113003562	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
331113003563	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331113003564	Coenzyme A binding pocket [chemical binding]; other site
331113003565	Phosphotransferase enzyme family; Region: APH; pfam01636
331113003566	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
331113003567	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
331113003568	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
331113003569	SelR domain; Region: SelR; pfam01641
331113003570	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
331113003571	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
331113003572	PhnA protein; Region: PhnA; pfam03831
331113003573	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
331113003574	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
331113003575	active site
331113003576	metal binding site [ion binding]; metal-binding site
331113003577	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331113003578	Walker A/P-loop; other site
331113003579	ATP binding site [chemical binding]; other site
331113003580	Q-loop/lid; other site
331113003581	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331113003582	ABC transporter signature motif; other site
331113003583	Walker B; other site
331113003584	D-loop; other site
331113003585	H-loop/switch region; other site
331113003586	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331113003587	AAA domain; Region: AAA_21; pfam13304
331113003588	Walker A/P-loop; other site
331113003589	ATP binding site [chemical binding]; other site
331113003590	Q-loop/lid; other site
331113003591	ABC transporter signature motif; other site
331113003592	Walker B; other site
331113003593	D-loop; other site
331113003594	H-loop/switch region; other site
331113003595	Predicted transcriptional regulators [Transcription]; Region: COG1695
331113003596	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
331113003597	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
331113003598	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
331113003599	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
331113003600	RNA binding surface [nucleotide binding]; other site
331113003601	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
331113003602	active site
331113003603	flavoprotein, HI0933 family; Region: TIGR00275
331113003604	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
331113003605	active site
331113003606	metal binding site [ion binding]; metal-binding site
331113003607	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331113003608	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331113003609	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331113003610	hypothetical protein; Validated; Region: PRK05868
331113003611	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
331113003612	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
331113003613	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
331113003614	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
331113003615	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
331113003616	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
331113003617	DNA binding site [nucleotide binding]
331113003618	active site
331113003619	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
331113003620	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
331113003621	ATP binding site [chemical binding]; other site
331113003622	Mg++ binding site [ion binding]; other site
331113003623	motif III; other site
331113003624	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
331113003625	nucleotide binding region [chemical binding]; other site
331113003626	ATP-binding site [chemical binding]; other site
331113003627	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
331113003628	active site clefts [active]
331113003629	zinc binding site [ion binding]; other site
331113003630	dimer interface [polypeptide binding]; other site
331113003631	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
331113003632	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
331113003633	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
331113003634	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331113003635	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331113003636	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331113003637	dimerization interface [polypeptide binding]; other site
331113003638	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
331113003639	UbiA prenyltransferase family; Region: UbiA; pfam01040
331113003640	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
331113003641	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
331113003642	Subunit I/III interface [polypeptide binding]; other site
331113003643	Subunit III/IV interface [polypeptide binding]; other site
331113003644	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
331113003645	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
331113003646	D-pathway; other site
331113003647	Putative ubiquinol binding site [chemical binding]; other site
331113003648	Low-spin heme (heme b) binding site [chemical binding]; other site
331113003649	Putative water exit pathway; other site
331113003650	Binuclear center (heme o3/CuB) [ion binding]; other site
331113003651	K-pathway; other site
331113003652	Putative proton exit pathway; other site
331113003653	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
331113003654	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
331113003655	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
331113003656	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
331113003657	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
331113003658	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331113003659	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331113003660	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
331113003661	catalytic site [active]
331113003662	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
331113003663	Mechanosensitive ion channel; Region: MS_channel; pfam00924
331113003664	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
331113003665	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
331113003666	DNA binding residues [nucleotide binding]
331113003667	dimer interface [polypeptide binding]; other site
331113003668	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
331113003669	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
331113003670	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
331113003671	putative active site [active]
331113003672	PhoH-like protein; Region: PhoH; pfam02562
331113003673	Bacterial SH3 domain; Region: SH3_3; cl17532
331113003674	Bacterial SH3 domain; Region: SH3_3; cl17532
331113003675	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
331113003676	dinuclear metal binding motif [ion binding]; other site
331113003677	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
331113003678	RmuC family; Region: RmuC; pfam02646
331113003679	Tetratricopeptide repeat; Region: TPR_12; pfam13424
331113003680	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
331113003681	ATP cone domain; Region: ATP-cone; pfam03477
331113003682	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
331113003683	ATP cone domain; Region: ATP-cone; pfam03477
331113003684	Class I ribonucleotide reductase; Region: RNR_I; cd01679
331113003685	active site
331113003686	dimer interface [polypeptide binding]; other site
331113003687	catalytic residues [active]
331113003688	effector binding site; other site
331113003689	R2 peptide binding site; other site
331113003690	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
331113003691	dimer interface [polypeptide binding]; other site
331113003692	putative radical transfer pathway; other site
331113003693	diiron center [ion binding]; other site
331113003694	tyrosyl radical; other site
331113003695	Uncharacterized protein domain similar to Clostridium thermocellum 2751; Region: Cthe_2751_like; cd11743
331113003696	dimer interface [polypeptide binding]; other site
331113003697	Uncharacterized protein domain similar to Clostridium thermocellum 2751; Region: Cthe_2751_like; cd11743
331113003698	dimer interface [polypeptide binding]; other site
331113003699	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
331113003700	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
331113003701	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
331113003702	Peptidase M16C associated; Region: M16C_assoc; pfam08367
331113003703	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
331113003704	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
331113003705	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
331113003706	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
331113003707	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
331113003708	protein binding site [polypeptide binding]; other site
331113003709	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
331113003710	protein binding site [polypeptide binding]; other site
331113003711	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331113003712	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
331113003713	extended (e) SDRs; Region: SDR_e; cd08946
331113003714	NAD(P) binding site [chemical binding]; other site
331113003715	active site
331113003716	substrate binding site [chemical binding]; other site
331113003717	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331113003718	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331113003719	active site
331113003720	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
331113003721	B12 binding site [chemical binding]; other site
331113003722	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
331113003723	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331113003724	FeS/SAM binding site; other site
331113003725	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
331113003726	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
331113003727	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
331113003728	tetramer interface [polypeptide binding]; other site
331113003729	TPP-binding site [chemical binding]; other site
331113003730	heterodimer interface [polypeptide binding]; other site
331113003731	phosphorylation loop region [posttranslational modification]
331113003732	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
331113003733	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
331113003734	alpha subunit interface [polypeptide binding]; other site
331113003735	TPP binding site [chemical binding]; other site
331113003736	heterodimer interface [polypeptide binding]; other site
331113003737	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
331113003738	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
331113003739	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
331113003740	inhibitor-cofactor binding pocket; inhibition site
331113003741	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331113003742	catalytic residue [active]
331113003743	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
331113003744	WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915
331113003745	Substrate binding site; other site
331113003746	Mg++ binding site; other site
331113003747	metal-binding site
331113003748	Mg++ binding site; other site
331113003749	metal-binding site
331113003750	Caenorhabditis protein of unknown function, DUF268; Region: DUF268; pfam03269
331113003751	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
331113003752	ADP-ribose binding site [chemical binding]; other site
331113003753	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
331113003754	Peptidase family M50; Region: Peptidase_M50; pfam02163
331113003755	active site
331113003756	putative substrate binding region [chemical binding]; other site
331113003757	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
331113003758	CoA binding domain; Region: CoA_binding; smart00881
331113003759	CoA-ligase; Region: Ligase_CoA; pfam00549
331113003760	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
331113003761	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
331113003762	CoA-ligase; Region: Ligase_CoA; pfam00549
331113003763	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
331113003764	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
331113003765	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
331113003766	P loop; other site
331113003767	GTP binding site [chemical binding]; other site
331113003768	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
331113003769	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
331113003770	primosome assembly protein PriA; Validated; Region: PRK05580
331113003771	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
331113003772	ATP binding site [chemical binding]; other site
331113003773	putative Mg++ binding site [ion binding]; other site
331113003774	helicase superfamily c-terminal domain; Region: HELICc; smart00490
331113003775	ATP-binding site [chemical binding]; other site
331113003776	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
331113003777	nucleophile elbow; other site
331113003778	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
331113003779	B3/4 domain; Region: B3_4; pfam03483
331113003780	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
331113003781	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
331113003782	dimer interface [polypeptide binding]; other site
331113003783	putative anticodon binding site; other site
331113003784	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
331113003785	motif 1; other site
331113003786	active site
331113003787	motif 2; other site
331113003788	motif 3; other site
331113003789	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
331113003790	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
331113003791	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
331113003792	phosphate acetyltransferase; Reviewed; Region: PRK05632
331113003793	DRTGG domain; Region: DRTGG; pfam07085
331113003794	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
331113003795	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
331113003796	propionate/acetate kinase; Provisional; Region: PRK12379
331113003797	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
331113003798	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
331113003799	active site
331113003800	HIGH motif; other site
331113003801	nucleotide binding site [chemical binding]; other site
331113003802	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
331113003803	KMSKS motif; other site
331113003804	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
331113003805	tRNA binding surface [nucleotide binding]; other site
331113003806	anticodon binding site; other site
331113003807	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
331113003808	putative acyl-acceptor binding pocket; other site
331113003809	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
331113003810	long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334
331113003811	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
331113003812	acyl-activating enzyme (AAE) consensus motif; other site
331113003813	AMP binding site [chemical binding]; other site
331113003814	active site
331113003815	CoA binding site [chemical binding]; other site
331113003816	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
331113003817	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331113003818	Coenzyme A binding pocket [chemical binding]; other site
331113003819	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
331113003820	nudix motif; other site
331113003821	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
331113003822	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
331113003823	dimer interface [polypeptide binding]; other site
331113003824	active site
331113003825	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
331113003826	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
331113003827	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
331113003828	active site
331113003829	(T/H)XGH motif; other site
331113003830	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
331113003831	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
331113003832	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
331113003833	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
331113003834	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
331113003835	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
331113003836	anti sigma factor interaction site; other site
331113003837	regulatory phosphorylation site [posttranslational modification]; other site
331113003838	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
331113003839	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
331113003840	G-X-X-G motif; other site
331113003841	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
331113003842	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
331113003843	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
331113003844	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
331113003845	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
331113003846	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
331113003847	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
331113003848	active site
331113003849	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331113003850	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331113003851	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113003852	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113003853	putative substrate translocation pore; other site
331113003854	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
331113003855	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
331113003856	active site
331113003857	homodimer interface [polypeptide binding]; other site
331113003858	cell division protein FtsW; Region: ftsW; TIGR02614
331113003859	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
331113003860	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
331113003861	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
331113003862	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
331113003863	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
331113003864	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
331113003865	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
331113003866	Mg++ binding site [ion binding]; other site
331113003867	putative catalytic motif [active]
331113003868	putative substrate binding site [chemical binding]; other site
331113003869	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
331113003870	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
331113003871	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
331113003872	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
331113003873	Radical SAM superfamily; Region: Radical_SAM; pfam04055
331113003874	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331113003875	FeS/SAM binding site; other site
331113003876	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331113003877	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
331113003878	NAD(P) binding site [chemical binding]; other site
331113003879	active site
331113003880	Response regulator receiver domain; Region: Response_reg; pfam00072
331113003881	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331113003882	active site
331113003883	phosphorylation site [posttranslational modification]
331113003884	intermolecular recognition site; other site
331113003885	dimerization interface [polypeptide binding]; other site
331113003886	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331113003887	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331113003888	active site
331113003889	phosphorylation site [posttranslational modification]
331113003890	intermolecular recognition site; other site
331113003891	dimerization interface [polypeptide binding]; other site
331113003892	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
331113003893	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
331113003894	substrate binding site; other site
331113003895	tetramer interface; other site
331113003896	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
331113003897	active site
331113003898	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
331113003899	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
331113003900	ATP-grasp domain; Region: ATP-grasp_4; cl17255
331113003901	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
331113003902	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
331113003903	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
331113003904	carboxyltransferase (CT) interaction site; other site
331113003905	biotinylation site [posttranslational modification]; other site
331113003906	elongation factor P; Provisional; Region: PRK12426
331113003907	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
331113003908	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
331113003909	RNA binding site [nucleotide binding]; other site
331113003910	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
331113003911	RNA binding site [nucleotide binding]; other site
331113003912	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
331113003913	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331113003914	motif II; other site
331113003915	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
331113003916	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
331113003917	phosphate binding site [ion binding]; other site
331113003918	putative substrate binding pocket [chemical binding]; other site
331113003919	dimer interface [polypeptide binding]; other site
331113003920	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
331113003921	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
331113003922	substrate binding site [chemical binding]; other site
331113003923	hexamer interface [polypeptide binding]; other site
331113003924	metal binding site [ion binding]; metal-binding site
331113003925	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
331113003926	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
331113003927	Na binding site [ion binding]; other site
331113003928	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
331113003929	putative catalytic residues [active]
331113003930	putative nucleotide binding site [chemical binding]; other site
331113003931	putative aspartate binding site [chemical binding]; other site
331113003932	ribosomal protein S1; Region: rpsA; TIGR00717
331113003933	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
331113003934	RNA binding site [nucleotide binding]; other site
331113003935	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
331113003936	RNA binding site [nucleotide binding]; other site
331113003937	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
331113003938	RNA binding site [nucleotide binding]; other site
331113003939	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
331113003940	RNA binding site [nucleotide binding]; other site
331113003941	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
331113003942	RNA binding site [nucleotide binding]; other site
331113003943	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
331113003944	RNA binding site [nucleotide binding]; other site
331113003945	transcription termination factor NusA; Region: NusA; TIGR01953
331113003946	NusA N-terminal domain; Region: NusA_N; pfam08529
331113003947	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
331113003948	RNA binding site [nucleotide binding]; other site
331113003949	homodimer interface [polypeptide binding]; other site
331113003950	NusA-like KH domain; Region: KH_5; pfam13184
331113003951	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
331113003952	G-X-X-G motif; other site
331113003953	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
331113003954	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
331113003955	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
331113003956	G1 box; other site
331113003957	putative GEF interaction site [polypeptide binding]; other site
331113003958	GTP/Mg2+ binding site [chemical binding]; other site
331113003959	Switch I region; other site
331113003960	G2 box; other site
331113003961	G3 box; other site
331113003962	Switch II region; other site
331113003963	G4 box; other site
331113003964	G5 box; other site
331113003965	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
331113003966	Translation-initiation factor 2; Region: IF-2; pfam11987
331113003967	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
331113003968	Ribosome-binding factor A; Region: RBFA; pfam02033
331113003969	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989
331113003970	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
331113003971	RNA binding site [nucleotide binding]; other site
331113003972	active site
331113003973	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
331113003974	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
331113003975	active site
331113003976	GTP-binding protein YchF; Reviewed; Region: PRK09601
331113003977	YchF GTPase; Region: YchF; cd01900
331113003978	G1 box; other site
331113003979	GTP/Mg2+ binding site [chemical binding]; other site
331113003980	Switch I region; other site
331113003981	G2 box; other site
331113003982	Switch II region; other site
331113003983	G3 box; other site
331113003984	G4 box; other site
331113003985	G5 box; other site
331113003986	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
331113003987	Peptidase C65 Otubain; Region: Peptidase_C65; pfam10275
331113003988	type III secretion system protein; Validated; Region: PRK06298
331113003989	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
331113003990	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
331113003991	FHIPEP family; Region: FHIPEP; pfam00771
331113003992	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331113003993	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113003994	putative substrate translocation pore; other site
331113003995	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113003996	HrpJ-like domain; Region: HrpJ; cl15454
331113003997	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
331113003998	4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446
331113003999	Protein-tyrosine phosphatase; Region: Y_phosphatase; pfam00102
331113004000	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
331113004001	active site
331113004002	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
331113004003	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
331113004004	binding surface
331113004005	TPR motif; other site
331113004006	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
331113004007	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
331113004008	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
331113004009	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
331113004010	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
331113004011	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
331113004012	Clp amino terminal domain; Region: Clp_N; pfam02861
331113004013	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113004014	Walker A motif; other site
331113004015	ATP binding site [chemical binding]; other site
331113004016	Walker B motif; other site
331113004017	arginine finger; other site
331113004018	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113004019	Walker A motif; other site
331113004020	ATP binding site [chemical binding]; other site
331113004021	Walker B motif; other site
331113004022	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
331113004023	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113004024	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
331113004025	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113004026	Walker A motif; other site
331113004027	ATP binding site [chemical binding]; other site
331113004028	Walker B motif; other site
331113004029	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
331113004030	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
331113004031	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331113004032	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331113004033	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
331113004034	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
331113004035	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
331113004036	PLD-like domain; Region: PLDc_2; pfam13091
331113004037	putative active site [active]
331113004038	catalytic site [active]
331113004039	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
331113004040	PLD-like domain; Region: PLDc_2; pfam13091
331113004041	putative active site [active]
331113004042	catalytic site [active]
331113004043	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
331113004044	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113004045	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113004046	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
331113004047	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
331113004048	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
331113004049	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
331113004050	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
331113004051	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
331113004052	4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446
331113004053	MarC family integral membrane protein; Region: MarC; cl00919
331113004054	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
331113004055	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
331113004056	dimerization interface 3.5A [polypeptide binding]; other site
331113004057	active site
331113004058	methionine aminopeptidase; Provisional; Region: PRK12318
331113004059	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
331113004060	active site
331113004061	nucleotide binding site [chemical binding]; other site
331113004062	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
331113004063	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
331113004064	hypothetical protein; Provisional; Region: PRK08201
331113004065	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
331113004066	metal binding site [ion binding]; metal-binding site
331113004067	heat shock protein HtpX; Provisional; Region: PRK05457
331113004068	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113004069	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113004070	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
331113004071	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113004072	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
331113004073	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
331113004074	putative ribose interaction site [chemical binding]; other site
331113004075	putative ADP binding site [chemical binding]; other site
331113004076	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
331113004077	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
331113004078	NADP binding site [chemical binding]; other site
331113004079	homopentamer interface [polypeptide binding]; other site
331113004080	substrate binding site [chemical binding]; other site
331113004081	active site
331113004082	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14611
331113004083	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
331113004084	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
331113004085	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
331113004086	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
331113004087	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
331113004088	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
331113004089	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
331113004090	putative active site [active]
331113004091	catalytic residue [active]
331113004092	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
331113004093	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
331113004094	5S rRNA interface [nucleotide binding]; other site
331113004095	CTC domain interface [polypeptide binding]; other site
331113004096	L16 interface [polypeptide binding]; other site
331113004097	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
331113004098	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
331113004099	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
331113004100	active site
331113004101	glycogen synthase; Provisional; Region: glgA; PRK00654
331113004102	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
331113004103	ADP-binding pocket [chemical binding]; other site
331113004104	homodimer interface [polypeptide binding]; other site
331113004105	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
331113004106	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
331113004107	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331113004108	FeS/SAM binding site; other site
331113004109	glycyl-tRNA synthetase; Provisional; Region: PRK14908
331113004110	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
331113004111	dimer interface [polypeptide binding]; other site
331113004112	motif 1; other site
331113004113	active site
331113004114	motif 2; other site
331113004115	motif 3; other site
331113004116	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
331113004117	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
331113004118	DNA primase; Validated; Region: dnaG; PRK05667
331113004119	CHC2 zinc finger; Region: zf-CHC2; pfam01807
331113004120	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
331113004121	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
331113004122	active site
331113004123	metal binding site [ion binding]; metal-binding site
331113004124	interdomain interaction site; other site
331113004125	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
331113004126	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
331113004127	MutS domain I; Region: MutS_I; pfam01624
331113004128	MutS domain II; Region: MutS_II; pfam05188
331113004129	MutS domain III; Region: MutS_III; pfam05192
331113004130	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
331113004131	Walker A/P-loop; other site
331113004132	ATP binding site [chemical binding]; other site
331113004133	Q-loop/lid; other site
331113004134	ABC transporter signature motif; other site
331113004135	Walker B; other site
331113004136	D-loop; other site
331113004137	H-loop/switch region; other site
331113004138	Ataxin-2 C-terminal region; Region: PAM2; pfam07145
331113004139	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
331113004140	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
331113004141	GIY-YIG motif/motif A; other site
331113004142	active site
331113004143	catalytic site [active]
331113004144	putative DNA binding site [nucleotide binding]; other site
331113004145	metal binding site [ion binding]; metal-binding site
331113004146	UvrB/uvrC motif; Region: UVR; pfam02151
331113004147	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
331113004148	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
331113004149	DNA binding site [nucleotide binding]
331113004150	Asp23 family; Region: Asp23; cl00574
331113004151	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
331113004152	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
331113004153	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
331113004154	Ribonuclease P; Region: Ribonuclease_P; pfam00825
331113004155	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
331113004156	Part of AAA domain; Region: AAA_19; pfam13245
331113004157	Family description; Region: UvrD_C_2; pfam13538
331113004158	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
331113004159	Domain of unknown function (DUF367); Region: DUF367; pfam04034
331113004160	Domain of unknown function (DUF1768); Region: DUF1768; cl01271
331113004161	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
331113004162	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
331113004163	aromatic amino acid transport protein; Region: araaP; TIGR00837
331113004164	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
331113004165	active site
331113004166	NTP binding site [chemical binding]; other site
331113004167	metal binding triad [ion binding]; metal-binding site
331113004168	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
331113004169	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
331113004170	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
331113004171	Fatty acid synthesis protein; Region: FA_synthesis; cl17261
331113004172	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
331113004173	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
331113004174	homodimer interface [polypeptide binding]; other site
331113004175	oligonucleotide binding site [chemical binding]; other site
331113004176	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
331113004177	putative acyl-acceptor binding pocket; other site
331113004178	Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025
331113004179	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
331113004180	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
331113004181	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
331113004182	TfoX N-terminal domain; Region: TfoX_N; cl17592
331113004183	RHS Repeat; Region: RHS_repeat; pfam05593
331113004184	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
331113004185	RHS Repeat; Region: RHS_repeat; cl11982
331113004186	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
331113004187	Homeodomain-like domain; Region: HTH_23; pfam13384
331113004188	Winged helix-turn helix; Region: HTH_29; pfam13551
331113004189	Winged helix-turn helix; Region: HTH_33; pfam13592
331113004190	DDE superfamily endonuclease; Region: DDE_3; pfam13358
331113004191	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
331113004192	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
331113004193	mercuric reductase; Validated; Region: PRK06370
331113004194	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331113004195	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
331113004196	Uncharacterized conserved protein [Function unknown]; Region: COG0398
331113004197	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
331113004198	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
331113004199	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331113004200	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331113004201	active site
331113004202	hypothetical protein; Validated; Region: PRK00110
331113004203	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
331113004204	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331113004205	Coenzyme A binding pocket [chemical binding]; other site
331113004206	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
331113004207	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331113004208	Coenzyme A binding pocket [chemical binding]; other site
331113004209	This domain is found in peptide chain release factors; Region: PCRF; smart00937
331113004210	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
331113004211	RF-1 domain; Region: RF-1; pfam00472
331113004212	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331113004213	active site
331113004214	SWI complex, BAF60b domains; Region: SWIB; smart00151
331113004215	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
331113004216	substrate binding site; other site
331113004217	dimer interface; other site
331113004218	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
331113004219	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
331113004220	dimerization interface 3.5A [polypeptide binding]; other site
331113004221	active site
331113004222	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
331113004223	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331113004224	motif II; other site
331113004225	Fic/DOC family; Region: Fic; pfam02661
331113004226	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
331113004227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331113004228	active site
331113004229	phosphorylation site [posttranslational modification]
331113004230	intermolecular recognition site; other site
331113004231	dimerization interface [polypeptide binding]; other site
331113004232	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113004233	Walker A motif; other site
331113004234	ATP binding site [chemical binding]; other site
331113004235	Walker B motif; other site
331113004236	arginine finger; other site
331113004237	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
331113004238	Peptidase M15; Region: Peptidase_M15_3; cl01194
331113004239	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
331113004240	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
331113004241	RDD family; Region: RDD; pfam06271
331113004242	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
331113004243	MORN repeat variant; Region: MORN_2; pfam07661
331113004244	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
331113004245	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588
331113004246	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
331113004247	30S subunit binding site; other site
331113004248	Predicted membrane protein [Function unknown]; Region: COG2259
331113004249	Methyltransferase domain; Region: Methyltransf_24; pfam13578
331113004250	Methyltransferase domain; Region: Methyltransf_24; pfam13578
331113004251	Methyltransferase domain; Region: Methyltransf_24; pfam13578
331113004252	Methyltransferase domain; Region: Methyltransf_24; pfam13578
331113004253	Recombination protein O N terminal; Region: RecO_N; pfam11967
331113004254	succinic semialdehyde dehydrogenase; Region: PLN02278
331113004255	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
331113004256	tetramerization interface [polypeptide binding]; other site
331113004257	NAD(P) binding site [chemical binding]; other site
331113004258	catalytic residues [active]
331113004259	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113004260	putative substrate translocation pore; other site
331113004261	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113004262	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
331113004263	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
331113004264	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
331113004265	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
331113004266	putative tRNA-binding site [nucleotide binding]; other site
331113004267	B3/4 domain; Region: B3_4; pfam03483
331113004268	tRNA synthetase B5 domain; Region: B5; pfam03484
331113004269	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
331113004270	dimer interface [polypeptide binding]; other site
331113004271	motif 1; other site
331113004272	motif 3; other site
331113004273	motif 2; other site
331113004274	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
331113004275	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
331113004276	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
331113004277	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
331113004278	DNA binding site [nucleotide binding]
331113004279	active site
331113004280	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
331113004281	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
331113004282	active site residue [active]
331113004283	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
331113004284	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
331113004285	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
331113004286	RNA binding surface [nucleotide binding]; other site
331113004287	endonuclease IV; Provisional; Region: PRK01060
331113004288	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
331113004289	AP (apurinic/apyrimidinic) site pocket; other site
331113004290	DNA interaction; other site
331113004291	Metal-binding active site; metal-binding site
331113004292	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
331113004293	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
331113004294	putative dimer interface [polypeptide binding]; other site
331113004295	putative anticodon binding site; other site
331113004296	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
331113004297	homodimer interface [polypeptide binding]; other site
331113004298	motif 1; other site
331113004299	motif 2; other site
331113004300	active site
331113004301	motif 3; other site
331113004302	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
331113004303	dimer interface [polypeptide binding]; other site
331113004304	putative tRNA-binding site [nucleotide binding]; other site
331113004305	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331113004306	Autotransporter beta-domain; Region: Autotransporter; smart00869
331113004307	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
331113004308	glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676
331113004309	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
331113004310	NAD(P) binding pocket [chemical binding]; other site
331113004311	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
331113004312	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
331113004313	active site
331113004314	catalytic site [active]
331113004315	metal binding site [ion binding]; metal-binding site
331113004316	recombination regulator RecX; Reviewed; Region: recX; PRK00117
331113004317	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
331113004318	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
331113004319	RNA binding surface [nucleotide binding]; other site
331113004320	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
331113004321	active site
331113004322	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
331113004323	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
331113004324	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
331113004325	AAA domain; Region: AAA_14; pfam13173
331113004326	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
331113004327	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
331113004328	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
331113004329	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
331113004330	putative active site [active]
331113004331	RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably...; Region: RING; cl17238
331113004332	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
331113004333	active site
331113004334	multimer interface [polypeptide binding]; other site
331113004335	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
331113004336	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
331113004337	putative active site [active]
331113004338	dimerization interface [polypeptide binding]; other site
331113004339	putative tRNAtyr binding site [nucleotide binding]; other site
331113004340	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
331113004341	active site
331113004342	substrate-binding site [chemical binding]; other site
331113004343	metal-binding site [ion binding]
331113004344	GTP binding site [chemical binding]; other site
331113004345	rod shape-determining protein MreB; Provisional; Region: PRK13927
331113004346	MreB and similar proteins; Region: MreB_like; cd10225
331113004347	nucleotide binding site [chemical binding]; other site
331113004348	Mg binding site [ion binding]; other site
331113004349	putative protofilament interaction site [polypeptide binding]; other site
331113004350	RodZ interaction site [polypeptide binding]; other site
331113004351	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
331113004352	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
331113004353	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
331113004354	ATP binding site [chemical binding]; other site
331113004355	putative Mg++ binding site [ion binding]; other site
331113004356	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
331113004357	nucleotide binding region [chemical binding]; other site
331113004358	ATP-binding site [chemical binding]; other site
331113004359	trigger factor; Provisional; Region: tig; PRK01490
331113004360	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
331113004361	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
331113004362	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
331113004363	oligomer interface [polypeptide binding]; other site
331113004364	active site residues [active]
331113004365	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
331113004366	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
331113004367	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113004368	Walker A motif; other site
331113004369	ATP binding site [chemical binding]; other site
331113004370	Walker B motif; other site
331113004371	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
331113004372	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
331113004373	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
331113004374	phosphopeptide binding site; other site
331113004375	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
331113004376	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
331113004377	phosphopeptide binding site; other site
331113004378	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331113004379	TPR repeat; Region: TPR_11; pfam13414
331113004380	binding surface
331113004381	TPR motif; other site
331113004382	type III secretion system ATPase; Provisional; Region: PRK06315
331113004383	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
331113004384	Walker A motif/ATP binding site; other site
331113004385	Walker B motif; other site
331113004386	phosphodiesterase; Provisional; Region: PRK12704
331113004387	type III secretion system protein; Validated; Region: PRK05933
331113004388	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
331113004389	Protein kinase domain; Region: Pkinase; pfam00069
331113004390	Catalytic domain of Protein Kinases; Region: PKc; cd00180
331113004391	active site
331113004392	ATP binding site [chemical binding]; other site
331113004393	substrate binding site [chemical binding]; other site
331113004394	activation loop (A-loop); other site
331113004395	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
331113004396	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
331113004397	Amidohydrolase; Region: Amidohydro_2; pfam04909
331113004398	active site
331113004399	type II secretion system protein D; Region: type_II_gspD; TIGR02517
331113004400	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
331113004401	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
331113004402	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
331113004403	Haemolytic domain; Region: Haemolytic; cl00506
331113004404	GTP-binding protein Der; Reviewed; Region: PRK00093
331113004405	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
331113004406	G1 box; other site
331113004407	GTP/Mg2+ binding site [chemical binding]; other site
331113004408	Switch I region; other site
331113004409	G2 box; other site
331113004410	Switch II region; other site
331113004411	G3 box; other site
331113004412	G4 box; other site
331113004413	G5 box; other site
331113004414	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
331113004415	G1 box; other site
331113004416	GTP/Mg2+ binding site [chemical binding]; other site
331113004417	Switch I region; other site
331113004418	G2 box; other site
331113004419	G3 box; other site
331113004420	Switch II region; other site
331113004421	G4 box; other site
331113004422	G5 box; other site
331113004423	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
331113004424	active site residue [active]
331113004425	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
331113004426	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
331113004427	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
331113004428	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
331113004429	ATP binding site [chemical binding]; other site
331113004430	putative Mg++ binding site [ion binding]; other site
331113004431	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
331113004432	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
331113004433	nucleotide binding region [chemical binding]; other site
331113004434	ATP-binding site [chemical binding]; other site
331113004435	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
331113004436	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
331113004437	hexamer interface [polypeptide binding]; other site
331113004438	ligand binding site [chemical binding]; other site
331113004439	putative active site [active]
331113004440	NAD(P) binding site [chemical binding]; other site
331113004441	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
331113004442	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
331113004443	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
331113004444	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
331113004445	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
331113004446	oligomer interface [polypeptide binding]; other site
331113004447	active site residues [active]
331113004448	serine hydroxymethyltransferase; Provisional; Region: PRK13580
331113004449	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
331113004450	dimer interface [polypeptide binding]; other site
331113004451	active site
331113004452	glycine-pyridoxal phosphate binding site [chemical binding]; other site
331113004453	folate binding site [chemical binding]; other site
331113004454	Chorismate mutase type II; Region: CM_2; smart00830
331113004455	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113004456	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113004457	putative substrate translocation pore; other site
331113004458	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113004459	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
331113004460	putative substrate translocation pore; other site
331113004461	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
331113004462	catalytic core [active]
331113004463	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
331113004464	Putative zinc ribbon domain; Region: DUF164; pfam02591
331113004465	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
331113004466	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
331113004467	active site
331113004468	Int/Topo IB signature motif; other site
331113004469	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
331113004470	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
331113004471	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
331113004472	ABC transporter; Region: ABC_tran_2; pfam12848
331113004473	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
331113004474	Zn-finger in Ran binding protein and others; Region: zf-RanBP; cl02656
331113004475	ribonuclease Z; Region: RNase_Z; TIGR02651
331113004476	Rhomboid family; Region: Rhomboid; pfam01694
331113004477	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
331113004478	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
331113004479	active site
331113004480	nucleotide binding site [chemical binding]; other site
331113004481	HIGH motif; other site
331113004482	KMSKS motif; other site
331113004483	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
331113004484	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113004485	Walker A motif; other site
331113004486	ATP binding site [chemical binding]; other site
331113004487	Walker B motif; other site
331113004488	arginine finger; other site
331113004489	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
331113004490	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
331113004491	Glycoprotease family; Region: Peptidase_M22; pfam00814
331113004492	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
331113004493	chaperone protein DnaJ; Provisional; Region: PRK14284
331113004494	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
331113004495	HSP70 interaction site [polypeptide binding]; other site
331113004496	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
331113004497	substrate binding site [polypeptide binding]; other site
331113004498	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
331113004499	Zn binding sites [ion binding]; other site
331113004500	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
331113004501	dimer interface [polypeptide binding]; other site
331113004502	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
331113004503	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331113004504	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
331113004505	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
331113004506	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
331113004507	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
331113004508	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
331113004509	DNA binding residues [nucleotide binding]
331113004510	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
331113004511	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cd00598
331113004512	Glyco_18 domain; Region: Glyco_18; smart00636
331113004513	active site
331113004514	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
331113004515	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
331113004516	Cupin domain; Region: Cupin_2; pfam07883
331113004517	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
331113004518	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
331113004519	active site
331113004520	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
331113004521	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331113004522	Coenzyme A binding pocket [chemical binding]; other site
331113004523	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
331113004524	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
331113004525	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
331113004526	active site
331113004527	nucleotide binding site [chemical binding]; other site
331113004528	HIGH motif; other site
331113004529	KMSKS motif; other site
331113004530	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
331113004531	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
331113004532	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
331113004533	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
331113004534	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
331113004535	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
331113004536	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331113004537	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
331113004538	active site
331113004539	Protein of unknown function (DUF502); Region: DUF502; cl01107
331113004540	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
331113004541	Mechanosensitive ion channel; Region: MS_channel; pfam00924
331113004542	Mechanosensitive ion channel; Region: MS_channel; pfam00924
331113004543	Predicted membrane protein [Function unknown]; Region: COG4420
331113004544	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
331113004545	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
331113004546	active site
331113004547	substrate binding site [chemical binding]; other site
331113004548	Mg2+ binding site [ion binding]; other site
331113004549	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
331113004550	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331113004551	Walker A/P-loop; other site
331113004552	ATP binding site [chemical binding]; other site
331113004553	Q-loop/lid; other site
331113004554	ABC transporter signature motif; other site
331113004555	Walker B; other site
331113004556	D-loop; other site
331113004557	H-loop/switch region; other site
331113004558	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
331113004559	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
331113004560	Protein of unknown function (DUF2608); Region: DUF2608; pfam11019
331113004561	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
331113004562	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
331113004563	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
331113004564	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
331113004565	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
331113004566	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331113004567	AAA domain; Region: AAA_28; pfam13521
331113004568	AAA domain; Region: AAA_17; pfam13207
331113004569	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
331113004570	nudix motif; other site
331113004571	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
331113004572	putative deacylase active site [active]
331113004573	L-ascorbate oxidase, plant type; Region: ascorbase; TIGR03388
331113004574	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
331113004575	Multicopper oxidase; Region: Cu-oxidase; pfam00394
331113004576	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
331113004577	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
331113004578	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
331113004579	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
331113004580	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
331113004581	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
331113004582	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
331113004583	alphaNTD homodimer interface [polypeptide binding]; other site
331113004584	alphaNTD - beta interaction site [polypeptide binding]; other site
331113004585	alphaNTD - beta' interaction site [polypeptide binding]; other site
331113004586	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
331113004587	30S ribosomal protein S11; Validated; Region: PRK05309
331113004588	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
331113004589	30S ribosomal protein S13; Region: bact_S13; TIGR03631
331113004590	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
331113004591	SecY translocase; Region: SecY; pfam00344
331113004592	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
331113004593	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
331113004594	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
331113004595	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
331113004596	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
331113004597	23S rRNA interface [nucleotide binding]; other site
331113004598	L21e interface [polypeptide binding]; other site
331113004599	5S rRNA interface [nucleotide binding]; other site
331113004600	L27 interface [polypeptide binding]; other site
331113004601	L5 interface [polypeptide binding]; other site
331113004602	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
331113004603	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
331113004604	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
331113004605	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
331113004606	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
331113004607	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
331113004608	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
331113004609	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
331113004610	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
331113004611	RNA binding site [nucleotide binding]; other site
331113004612	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
331113004613	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
331113004614	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
331113004615	23S rRNA interface [nucleotide binding]; other site
331113004616	putative translocon interaction site; other site
331113004617	signal recognition particle (SRP54) interaction site; other site
331113004618	L23 interface [polypeptide binding]; other site
331113004619	trigger factor interaction site; other site
331113004620	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
331113004621	23S rRNA interface [nucleotide binding]; other site
331113004622	5S rRNA interface [nucleotide binding]; other site
331113004623	putative antibiotic binding site [chemical binding]; other site
331113004624	L25 interface [polypeptide binding]; other site
331113004625	L27 interface [polypeptide binding]; other site
331113004626	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
331113004627	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
331113004628	G-X-X-G motif; other site
331113004629	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
331113004630	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
331113004631	putative translocon binding site; other site
331113004632	protein-rRNA interface [nucleotide binding]; other site
331113004633	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
331113004634	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
331113004635	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
331113004636	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
331113004637	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
331113004638	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
331113004639	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
331113004640	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
331113004641	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
331113004642	putative active site [active]
331113004643	substrate binding site [chemical binding]; other site
331113004644	putative cosubstrate binding site; other site
331113004645	catalytic site [active]
331113004646	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
331113004647	substrate binding site [chemical binding]; other site
331113004648	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
331113004649	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
331113004650	active site
331113004651	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
331113004652	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
331113004653	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
331113004654	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
331113004655	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
331113004656	putative active site [active]
331113004657	catalytic triad [active]
331113004658	putative dimer interface [polypeptide binding]; other site
331113004659	Predicted membrane protein [Function unknown]; Region: COG2259
331113004660	16S rRNA methyltransferase B; Provisional; Region: PRK14902
331113004661	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
331113004662	SurA N-terminal domain; Region: SurA_N; pfam09312
331113004663	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
331113004664	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113004665	S-adenosylmethionine binding site [chemical binding]; other site
331113004666	Protein of unknown function, DUF393; Region: DUF393; pfam04134
331113004667	Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310
331113004668	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
331113004669	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
331113004670	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
331113004671	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
331113004672	BNR repeat-like domain; Region: BNR_2; pfam13088
331113004673	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
331113004674	catalytic site [active]
331113004675	Asp-box motif; other site
331113004676	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
331113004677	putative catalytic site [active]
331113004678	putative metal binding site [ion binding]; other site
331113004679	putative phosphate binding site [ion binding]; other site
331113004680	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
331113004681	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331113004682	ATP binding site [chemical binding]; other site
331113004683	Mg2+ binding site [ion binding]; other site
331113004684	G-X-G motif; other site
331113004685	Lipopolysaccharide-assembly; Region: LptE; pfam04390
331113004686	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331113004687	binding surface
331113004688	TPR motif; other site
331113004689	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
331113004690	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
331113004691	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
331113004692	active site
331113004693	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
331113004694	generic binding surface I; other site
331113004695	generic binding surface II; other site
331113004696	regulatory protein UhpC; Provisional; Region: PRK11663
331113004697	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113004698	putative substrate translocation pore; other site
331113004699	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
331113004700	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
331113004701	dimer interface [polypeptide binding]; other site
331113004702	motif 1; other site
331113004703	active site
331113004704	motif 2; other site
331113004705	motif 3; other site
331113004706	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
331113004707	anticodon binding site; other site
331113004708	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
331113004709	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
331113004710	dimer interface [polypeptide binding]; other site
331113004711	anticodon binding site; other site
331113004712	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
331113004713	homodimer interface [polypeptide binding]; other site
331113004714	motif 1; other site
331113004715	active site
331113004716	motif 2; other site
331113004717	GAD domain; Region: GAD; pfam02938
331113004718	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
331113004719	active site
331113004720	motif 3; other site
331113004721	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
331113004722	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
331113004723	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
331113004724	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
331113004725	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
331113004726	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
331113004727	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
331113004728	catalytic residues [active]
331113004729	Thiamine pyrophosphokinase; Region: TPK; cd07995
331113004730	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
331113004731	active site
331113004732	dimerization interface [polypeptide binding]; other site
331113004733	thiamine binding site [chemical binding]; other site
331113004734	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
331113004735	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
331113004736	putative acyl-acceptor binding pocket; other site
331113004737	cytidylate kinase; Provisional; Region: cmk; PRK00023
331113004738	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
331113004739	CMP-binding site; other site
331113004740	The sites determining sugar specificity; other site
331113004741	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
331113004742	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
331113004743	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
331113004744	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
331113004745	catalytic residue [active]
331113004746	putative FPP diphosphate  binding site; other site
331113004747	putative FPP binding hydrophobic cleft; other site
331113004748	dimer interface [polypeptide binding]; other site
331113004749	putative IPP diphosphate binding site; other site
331113004750	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
331113004751	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
331113004752	GDP-binding site [chemical binding]; other site
331113004753	ACT binding site; other site
331113004754	IMP binding site; other site
331113004755	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
331113004756	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
331113004757	RHS Repeat; Region: RHS_repeat; pfam05593
331113004758	RHS Repeat; Region: RHS_repeat; cl11982
331113004759	RHS Repeat; Region: RHS_repeat; pfam05593
331113004760	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
331113004761	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
331113004762	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
331113004763	Protein export membrane protein; Region: SecD_SecF; pfam02355
331113004764	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
331113004765	DHH family; Region: DHH; pfam01368
331113004766	DHHA1 domain; Region: DHHA1; pfam02272
331113004767	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
331113004768	TRAM domain; Region: TRAM; cl01282
331113004769	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113004770	S-adenosylmethionine binding site [chemical binding]; other site
331113004771	Helix-turn-helix domain; Region: HTH_17; cl17695
331113004772	Helix-turn-helix domain; Region: HTH_17; pfam12728
331113004773	C-terminal peptidase (prc); Region: prc; TIGR00225
331113004774	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
331113004775	protein binding site [polypeptide binding]; other site
331113004776	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
331113004777	Catalytic dyad [active]
331113004778	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
331113004779	Hemerythrin-like domain; Region: Hr-like; cd12108
331113004780	Fe binding site [ion binding]; other site
331113004781	Protein of unknown function (DUF805); Region: DUF805; pfam05656
331113004782	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
331113004783	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
331113004784	HIGH motif; other site
331113004785	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
331113004786	active site
331113004787	KMSKS motif; other site
331113004788	FAD binding domain; Region: FAD_binding_1; pfam00667
331113004789	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
331113004790	FAD binding pocket [chemical binding]; other site
331113004791	conserved FAD binding motif [chemical binding]; other site
331113004792	phosphate binding motif [ion binding]; other site
331113004793	beta-alpha-beta structure motif; other site
331113004794	NAD binding pocket [chemical binding]; other site
331113004795	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
331113004796	homotrimer interaction site [polypeptide binding]; other site
331113004797	zinc binding site [ion binding]; other site
331113004798	CDP-binding sites; other site
331113004799	pyruvate carboxylase; Region: pyruv_carbox; TIGR01235
331113004800	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
331113004801	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
331113004802	hinge; other site
331113004803	active site
331113004804	Poly (ADP-ribose) glycohydrolase (PARG); Region: PARG_cat; pfam05028
331113004805	Radical SAM superfamily; Region: Radical_SAM; pfam04055
331113004806	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331113004807	FeS/SAM binding site; other site
331113004808	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
331113004809	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
331113004810	arginine-tRNA ligase; Region: PLN02286
331113004811	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
331113004812	active site
331113004813	HIGH motif; other site
331113004814	KMSK motif region; other site
331113004815	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
331113004816	tRNA binding surface [nucleotide binding]; other site
331113004817	anticodon binding site; other site
331113004818	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
331113004819	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
331113004820	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
331113004821	NAD binding site [chemical binding]; other site
331113004822	Phe binding site; other site
331113004823	Protein of unknown function (DUF2709); Region: DUF2709; pfam10915
331113004824	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
331113004825	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
331113004826	G1 box; other site
331113004827	GTP/Mg2+ binding site [chemical binding]; other site
331113004828	Switch I region; other site
331113004829	G2 box; other site
331113004830	G3 box; other site
331113004831	Switch II region; other site
331113004832	G4 box; other site
331113004833	G5 box; other site
331113004834	DNA polymerase III subunit epsilon; Validated; Region: PRK06310
331113004835	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
331113004836	active site
331113004837	catalytic site [active]
331113004838	substrate binding site [chemical binding]; other site
331113004839	Protein of unknown function (DUF3820); Region: DUF3820; cl01411
331113004840	Phosphoglycerate kinase; Region: PGK; pfam00162
331113004841	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
331113004842	substrate binding site [chemical binding]; other site
331113004843	hinge regions; other site
331113004844	ADP binding site [chemical binding]; other site
331113004845	catalytic site [active]
331113004846	TLC ATP/ADP transporter; Region: TLC; pfam03219
331113004847	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
331113004848	Caleosin related protein; Region: Caleosin; pfam05042
331113004849	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
331113004850	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
331113004851	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
331113004852	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
331113004853	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
331113004854	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
331113004855	tandem repeat interface [polypeptide binding]; other site
331113004856	oligomer interface [polypeptide binding]; other site
331113004857	active site residues [active]
331113004858	DNA polymerase I; Provisional; Region: PRK05755
331113004859	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
331113004860	active site
331113004861	metal binding site 1 [ion binding]; metal-binding site
331113004862	putative 5' ssDNA interaction site; other site
331113004863	metal binding site 3; metal-binding site
331113004864	metal binding site 2 [ion binding]; metal-binding site
331113004865	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
331113004866	putative DNA binding site [nucleotide binding]; other site
331113004867	putative metal binding site [ion binding]; other site
331113004868	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
331113004869	active site
331113004870	catalytic site [active]
331113004871	substrate binding site [chemical binding]; other site
331113004872	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
331113004873	active site
331113004874	DNA binding site [nucleotide binding]
331113004875	catalytic site [active]
331113004876	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
331113004877	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
331113004878	CoA-binding site [chemical binding]; other site
331113004879	ATP-binding [chemical binding]; other site
331113004880	transcription termination factor Rho; Provisional; Region: rho; PRK09376
331113004881	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
331113004882	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
331113004883	RNA binding site [nucleotide binding]; other site
331113004884	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
331113004885	multimer interface [polypeptide binding]; other site
331113004886	Walker A motif; other site
331113004887	ATP binding site [chemical binding]; other site
331113004888	Walker B motif; other site
331113004889	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
331113004890	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
331113004891	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
331113004892	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
331113004893	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
331113004894	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
331113004895	nucleotide binding site [chemical binding]; other site
331113004896	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
331113004897	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
331113004898	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
331113004899	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
331113004900	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
331113004901	active site
331113004902	NTP binding site [chemical binding]; other site
331113004903	metal binding triad [ion binding]; metal-binding site
331113004904	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
331113004905	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113004906	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113004907	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331113004908	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331113004909	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
331113004910	dimerization interface [polypeptide binding]; other site
331113004911	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
331113004912	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
331113004913	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
331113004914	active site
331113004915	nucleophile elbow; other site
331113004916	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
331113004917	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
331113004918	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
331113004919	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
331113004920	RNA binding site [nucleotide binding]; other site
331113004921	homodimer interface [polypeptide binding]; other site
331113004922	GTPase RsgA; Reviewed; Region: PRK00098
331113004923	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
331113004924	GTPase/Zn-binding domain interface [polypeptide binding]; other site
331113004925	GTP/Mg2+ binding site [chemical binding]; other site
331113004926	G4 box; other site
331113004927	G5 box; other site
331113004928	G1 box; other site
331113004929	Switch I region; other site
331113004930	G2 box; other site
331113004931	G3 box; other site
331113004932	Switch II region; other site
331113004933	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113004934	Walker A motif; other site
331113004935	ATP binding site [chemical binding]; other site
331113004936	Walker B motif; other site
331113004937	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
331113004938	Helix-turn-helix domain; Region: HTH_36; pfam13730
331113004939	enolase; Provisional; Region: eno; PRK00077
331113004940	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
331113004941	dimer interface [polypeptide binding]; other site
331113004942	metal binding site [ion binding]; metal-binding site
331113004943	substrate binding pocket [chemical binding]; other site
331113004944	Cupin domain; Region: Cupin_2; cl17218
331113004945	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
331113004946	AAA domain; Region: AAA_14; pfam13173
331113004947	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
331113004948	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
331113004949	dimer interface [polypeptide binding]; other site
331113004950	decamer (pentamer of dimers) interface [polypeptide binding]; other site
331113004951	catalytic triad [active]
331113004952	peroxidatic and resolving cysteines [active]
331113004953	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
331113004954	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
331113004955	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331113004956	S-adenosylmethionine binding site [chemical binding]; other site
331113004957	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
331113004958	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
331113004959	ring oligomerisation interface [polypeptide binding]; other site
331113004960	ATP/Mg binding site [chemical binding]; other site
331113004961	stacking interactions; other site
331113004962	hinge regions; other site
331113004963	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
331113004964	oligomerisation interface [polypeptide binding]; other site
331113004965	mobile loop; other site
331113004966	roof hairpin; other site
331113004967	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
331113004968	Proline dehydrogenase; Region: Pro_dh; cl03282
331113004969	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
331113004970	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
331113004971	Glutamate binding site [chemical binding]; other site
331113004972	NAD binding site [chemical binding]; other site
331113004973	catalytic residues [active]
331113004974	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
331113004975	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
331113004976	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
331113004977	Part of AAA domain; Region: AAA_19; pfam13245
331113004978	Family description; Region: UvrD_C_2; pfam13538
331113004979	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
331113004980	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
331113004981	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
331113004982	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
331113004983	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331113004984	active site
331113004985	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331113004986	active site
331113004987	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
331113004988	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
331113004989	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
331113004990	active site
331113004991	DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319
331113004992	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
331113004993	active site
331113004994	interdomain interaction site; other site
331113004995	putative metal-binding site [ion binding]; other site
331113004996	nucleotide binding site [chemical binding]; other site
331113004997	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
331113004998	domain I; other site
331113004999	DNA binding groove [nucleotide binding]
331113005000	phosphate binding site [ion binding]; other site
331113005001	domain II; other site
331113005002	domain III; other site
331113005003	nucleotide binding site [chemical binding]; other site
331113005004	catalytic site [active]
331113005005	domain IV; other site
331113005006	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
331113005007	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
331113005008	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
331113005009	SWI complex, BAF60b domains; Region: SWIB; smart00151
331113005010	Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784
331113005011	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
331113005012	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
331113005013	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
331113005014	putative ADP-binding pocket [chemical binding]; other site
331113005015	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
331113005016	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
331113005017	tetramer interface [polypeptide binding]; other site
331113005018	TPP-binding site [chemical binding]; other site
331113005019	heterodimer interface [polypeptide binding]; other site
331113005020	phosphorylation loop region [posttranslational modification]
331113005021	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
331113005022	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
331113005023	alpha subunit interface [polypeptide binding]; other site
331113005024	TPP binding site [chemical binding]; other site
331113005025	heterodimer interface [polypeptide binding]; other site
331113005026	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
331113005027	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
331113005028	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113005029	Walker A motif; other site
331113005030	ATP binding site [chemical binding]; other site
331113005031	Walker B motif; other site
331113005032	AAA domain; Region: AAA_14; pfam13173
331113005033	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
331113005034	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
331113005035	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
331113005036	Walker A/P-loop; other site
331113005037	ATP binding site [chemical binding]; other site
331113005038	Q-loop/lid; other site
331113005039	ABC transporter signature motif; other site
331113005040	Walker B; other site
331113005041	D-loop; other site
331113005042	H-loop/switch region; other site
331113005043	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
331113005044	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
331113005045	excinuclease ABC subunit B; Provisional; Region: PRK05298
331113005046	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
331113005047	ATP binding site [chemical binding]; other site
331113005048	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
331113005049	nucleotide binding region [chemical binding]; other site
331113005050	ATP-binding site [chemical binding]; other site
331113005051	Ultra-violet resistance protein B; Region: UvrB; pfam12344
331113005052	UvrB/uvrC motif; Region: UVR; pfam02151
331113005053	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
331113005054	aromatic amino acid transport protein; Region: araaP; TIGR00837
331113005055	AAA ATPase domain; Region: AAA_16; pfam13191
331113005056	Archaeal ATPase; Region: Arch_ATPase; pfam01637
331113005057	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331113005058	Walker A motif; other site
331113005059	ATP binding site [chemical binding]; other site
331113005060	Walker B motif; other site
331113005061	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
331113005062	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
331113005063	aromatic amino acid transport protein; Region: araaP; TIGR00837
331113005064	Thymidylate synthase complementing protein; Region: Thy1; cl03630
331113005065	Thymidylate synthase complementing protein; Region: Thy1; pfam02511
331113005066	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
331113005067	dimer interface [polypeptide binding]; other site
331113005068	allosteric magnesium binding site [ion binding]; other site
331113005069	active site
331113005070	aspartate-rich active site metal binding site; other site
331113005071	Schiff base residues; other site
331113005072	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
331113005073	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
331113005074	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
331113005075	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
331113005076	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
331113005077	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
331113005078	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
331113005079	AAA ATPase domain; Region: AAA_16; pfam13191
331113005080	Archaeal ATPase; Region: Arch_ATPase; pfam01637
331113005081	transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330
331113005082	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
331113005083	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
331113005084	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
331113005085	active site
331113005086	dimerization interface [polypeptide binding]; other site
331113005087	YacP-like NYN domain; Region: NYN_YacP; cl01491
331113005088	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
331113005089	NlpC/P60 family; Region: NLPC_P60; cl17555
331113005090	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
331113005091	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
331113005092	peptide binding site [polypeptide binding]; other site
331113005093	Protein of unknown function (DUF1664); Region: DUF1664; pfam07889
331113005094	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331113005095	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
331113005096	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
331113005097	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
331113005098	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
331113005099	YGGT family; Region: YGGT; pfam02325
331113005100	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
331113005101	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
331113005102	FMN binding site [chemical binding]; other site
331113005103	active site
331113005104	catalytic residues [active]
331113005105	substrate binding site [chemical binding]; other site
331113005106	Acylphosphatase; Region: Acylphosphatase; pfam00708
331113005107	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
331113005108	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
331113005109	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331113005110	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331113005111	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
331113005112	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
331113005113	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
331113005114	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
331113005115	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
331113005116	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
331113005117	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
331113005118	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
331113005119	DNA binding residues [nucleotide binding]
331113005120	Competence protein CoiA-like family; Region: CoiA; cl11541
331113005121	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
331113005122	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
331113005123	nudix motif; other site
331113005124	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331113005125	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331113005126	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331113005127	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331113005128	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331113005129	Mannosyltransferase putative; Region: Mannosyl_trans3; pfam11051
331113005130	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331113005131	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331113005132	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
331113005133	AAA domain; Region: AAA_30; pfam13604
331113005134	AAA domain; Region: AAA_22; pfam13401
331113005135	Family description; Region: UvrD_C_2; pfam13538
331113005136	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
331113005137	RHS Repeat; Region: RHS_repeat; pfam05593
331113005138	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
331113005139	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
331113005140	active site
331113005141	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
331113005142	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
331113005143	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
331113005144	DNA binding residues [nucleotide binding]
331113005145	dimerization interface [polypeptide binding]; other site
331113005146	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
331113005147	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
331113005148	RHS Repeat; Region: RHS_repeat; pfam05593
331113005149	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
331113005150	RHS Repeat; Region: RHS_repeat; pfam05593
331113005151	RHS Repeat; Region: RHS_repeat; pfam05593
331113005152	RHS Repeat; Region: RHS_repeat; pfam05593
331113005153	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
331113005154	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
331113005155	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
331113005156	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331113005157	DNA binding residues [nucleotide binding]
331113005158	dimerization interface [polypeptide binding]; other site
331113005159	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
331113005160	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331113005161	DNA binding residues [nucleotide binding]