-- dump date   	20140620_065836
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
886293000001	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
886293000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
886293000003	DnaA N-terminal domain; Region: DnaA_N; pfam11638
886293000004	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293000005	Walker A motif; other site
886293000006	ATP binding site [chemical binding]; other site
886293000007	Walker B motif; other site
886293000008	arginine finger; other site
886293000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
886293000010	DnaA box-binding interface [nucleotide binding]; other site
886293000011	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
886293000012	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
886293000013	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
886293000014	TPR motif; other site
886293000015	binding surface
886293000016	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293000017	binding surface
886293000018	TPR motif; other site
886293000019	TPR repeat; Region: TPR_11; pfam13414
886293000020	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
886293000021	metal ion-dependent adhesion site (MIDAS); other site
886293000022	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
886293000023	metal ion-dependent adhesion site (MIDAS); other site
886293000024	hypothetical protein; Provisional; Region: PRK01346
886293000025	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
886293000026	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
886293000027	putative active site [active]
886293000028	putative metal binding site [ion binding]; other site
886293000029	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
886293000030	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293000031	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
886293000032	active site
886293000033	zinc binding site [ion binding]; other site
886293000034	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
886293000035	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
886293000036	Cu(I) binding site [ion binding]; other site
886293000037	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
886293000038	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
886293000039	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
886293000040	FOG: WD40-like repeat [Function unknown]; Region: COG1520
886293000041	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
886293000042	Lumazine binding domain; Region: Lum_binding; pfam00677
886293000043	Lumazine binding domain; Region: Lum_binding; pfam00677
886293000044	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
886293000045	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
886293000046	active site
886293000047	catalytic tetrad [active]
886293000048	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
886293000049	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
886293000050	Ligand binding site; other site
886293000051	Putative Catalytic site; other site
886293000052	DXD motif; other site
886293000053	Uncharacterized conserved protein [Function unknown]; Region: COG3339
886293000054	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293000055	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293000056	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
886293000057	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
886293000058	tetramer interface [polypeptide binding]; other site
886293000059	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293000060	catalytic residue [active]
886293000061	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
886293000062	Uncharacterized conserved protein [Function unknown]; Region: COG1262
886293000063	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
886293000064	Penicillinase repressor; Region: Pencillinase_R; pfam03965
886293000065	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
886293000066	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
886293000067	active site
886293000068	catalytic tetrad [active]
886293000069	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
886293000070	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293000071	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293000072	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
886293000073	CGNR zinc finger; Region: zf-CGNR; pfam11706
886293000074	haloalkane dehalogenase; Provisional; Region: PRK03592
886293000075	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
886293000076	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
886293000077	NADP binding site [chemical binding]; other site
886293000078	dimer interface [polypeptide binding]; other site
886293000079	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293000080	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293000081	structural tetrad; other site
886293000082	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293000083	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293000084	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293000085	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293000086	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293000087	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293000088	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293000089	DNA binding residues [nucleotide binding]
886293000090	Flavivirus non-structural protein NS4A; Region: Flavi_NS4A; pfam01350
886293000091	Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075
886293000092	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293000093	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293000094	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293000095	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293000096	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293000097	Predicted transcriptional regulators [Transcription]; Region: COG1695
886293000098	Transcriptional regulator PadR-like family; Region: PadR; cl17335
886293000099	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
886293000100	Beta-lactamase; Region: Beta-lactamase; pfam00144
886293000101	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
886293000102	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293000103	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293000104	structural tetrad; other site
886293000105	WD domain, G-beta repeat; Region: WD40; pfam00400
886293000106	Caspase domain; Region: Peptidase_C14; pfam00656
886293000107	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293000108	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293000109	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293000110	DNA binding residues [nucleotide binding]
886293000111	guanine deaminase; Provisional; Region: PRK09228
886293000112	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293000113	active site
886293000114	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
886293000115	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293000116	extended (e) SDRs; Region: SDR_e; cd08946
886293000117	NAD(P) binding site [chemical binding]; other site
886293000118	active site
886293000119	substrate binding site [chemical binding]; other site
886293000120	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
886293000121	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293000122	Protein of unknown function (DUF1587); Region: PSD3; pfam07626
886293000123	Protein of unknown function (DUF1595); Region: PSD5; pfam07637
886293000124	Protein of unknown function (DUF1592); Region: PSD4; pfam07631
886293000125	Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627
886293000126	Protein of unknown function (DUF1585); Region: PSD2; pfam07624
886293000127	Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586
886293000128	Predicted amidohydrolase [General function prediction only]; Region: COG0388
886293000129	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
886293000130	active site
886293000131	catalytic triad [active]
886293000132	dimer interface [polypeptide binding]; other site
886293000133	HEAT repeats; Region: HEAT_2; pfam13646
886293000134	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
886293000135	protein-splicing catalytic site; other site
886293000136	thioester formation/cholesterol transfer; other site
886293000137	Pretoxin HINT domain; Region: PT-HINT; pfam07591
886293000138	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
886293000139	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000140	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
886293000141	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000142	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293000143	putative substrate translocation pore; other site
886293000144	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
886293000145	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000146	cystathionine gamma-synthase; Provisional; Region: PRK08249
886293000147	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
886293000148	homodimer interface [polypeptide binding]; other site
886293000149	substrate-cofactor binding pocket; other site
886293000150	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293000151	catalytic residue [active]
886293000152	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000153	Isochorismatase family; Region: Isochorismatase; pfam00857
886293000154	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
886293000155	catalytic triad [active]
886293000156	conserved cis-peptide bond; other site
886293000157	PEP-CTERM motif; Region: VPEP; pfam07589
886293000158	BNR repeat-like domain; Region: BNR_2; pfam13088
886293000159	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
886293000160	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
886293000161	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000162	prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294
886293000163	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133
886293000164	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
886293000165	PemK-like protein; Region: PemK; cl00995
886293000166	PemK-like protein; Region: PemK; pfam02452
886293000167	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
886293000168	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
886293000169	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293000170	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293000171	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000172	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
886293000173	anti sigma factor interaction site; other site
886293000174	regulatory phosphorylation site [posttranslational modification]; other site
886293000175	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
886293000176	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
886293000177	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000178	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000179	prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294
886293000180	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293000181	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293000182	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293000183	TPR motif; other site
886293000184	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293000185	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293000186	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
886293000187	Protein export membrane protein; Region: SecD_SecF; cl14618
886293000188	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
886293000189	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293000190	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293000191	DNA binding residues [nucleotide binding]
886293000192	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293000193	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293000194	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
886293000195	putative hydrophobic ligand binding site [chemical binding]; other site
886293000196	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293000197	dimerization interface [polypeptide binding]; other site
886293000198	putative DNA binding site [nucleotide binding]; other site
886293000199	putative Zn2+ binding site [ion binding]; other site
886293000200	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
886293000201	putative active site [active]
886293000202	SWIM zinc finger; Region: SWIM; pfam04434
886293000203	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
886293000204	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
886293000205	ATP binding site [chemical binding]; other site
886293000206	putative Mg++ binding site [ion binding]; other site
886293000207	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293000208	nucleotide binding region [chemical binding]; other site
886293000209	ATP-binding site [chemical binding]; other site
886293000210	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
886293000211	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293000212	ATP binding site [chemical binding]; other site
886293000213	Mg2+ binding site [ion binding]; other site
886293000214	G-X-G motif; other site
886293000215	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
886293000216	anchoring element; other site
886293000217	dimer interface [polypeptide binding]; other site
886293000218	ATP binding site [chemical binding]; other site
886293000219	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
886293000220	active site
886293000221	putative metal-binding site [ion binding]; other site
886293000222	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
886293000223	Protein of unknown function (DUF721); Region: DUF721; pfam05258
886293000224	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
886293000225	DNA polymerase III subunit beta; Validated; Region: PRK05643
886293000226	putative DNA binding surface [nucleotide binding]; other site
886293000227	dimer interface [polypeptide binding]; other site
886293000228	beta-clamp/clamp loader binding surface; other site
886293000229	beta-clamp/translesion DNA polymerase binding surface; other site
886293000230	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
886293000231	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
886293000232	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293000233	putative substrate translocation pore; other site
886293000234	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000235	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
886293000236	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
886293000237	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
886293000238	active site
886293000239	catalytic triad [active]
886293000240	oxyanion hole [active]
886293000241	hypothetical protein; Provisional; Region: PRK06185
886293000242	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
886293000243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
886293000244	active site
886293000245	phosphorylation site [posttranslational modification]
886293000246	intermolecular recognition site; other site
886293000247	dimerization interface [polypeptide binding]; other site
886293000248	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
886293000249	catalytic motif [active]
886293000250	Catalytic residue [active]
886293000251	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293000252	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
886293000253	catalytic motif [active]
886293000254	Catalytic residue [active]
886293000255	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293000256	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
886293000257	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
886293000258	DnaA box-binding interface [nucleotide binding]; other site
886293000259	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
886293000260	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
886293000261	nucleotide binding site [chemical binding]; other site
886293000262	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
886293000263	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
886293000264	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
886293000265	HSP70 interaction site [polypeptide binding]; other site
886293000266	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293000267	TPR motif; other site
886293000268	binding surface
886293000269	DNA gyrase subunit A; Validated; Region: PRK05560
886293000270	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
886293000271	CAP-like domain; other site
886293000272	active site
886293000273	primary dimer interface [polypeptide binding]; other site
886293000274	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
886293000275	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
886293000276	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
886293000277	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
886293000278	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
886293000279	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
886293000280	Uncharacterized conserved protein [Function unknown]; Region: COG4748
886293000281	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
886293000282	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
886293000283	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
886293000284	Putative esterase; Region: Esterase; pfam00756
886293000285	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
886293000286	catalytic residues [active]
886293000287	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293000288	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
886293000289	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293000290	maltose O-acetyltransferase; Provisional; Region: PRK10092
886293000291	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
886293000292	active site
886293000293	substrate binding site [chemical binding]; other site
886293000294	trimer interface [polypeptide binding]; other site
886293000295	CoA binding site [chemical binding]; other site
886293000296	short chain dehydrogenase; Provisional; Region: PRK08219
886293000297	classical (c) SDRs; Region: SDR_c; cd05233
886293000298	NAD(P) binding site [chemical binding]; other site
886293000299	active site
886293000300	Cupin domain; Region: Cupin_2; pfam07883
886293000301	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
886293000302	short chain dehydrogenase; Provisional; Region: PRK07577
886293000303	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
886293000304	putative NAD(P) binding site [chemical binding]; other site
886293000305	homodimer interface [polypeptide binding]; other site
886293000306	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293000307	Coenzyme A binding pocket [chemical binding]; other site
886293000308	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
886293000309	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
886293000310	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
886293000311	active site clefts [active]
886293000312	zinc binding site [ion binding]; other site
886293000313	dimer interface [polypeptide binding]; other site
886293000314	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
886293000315	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
886293000316	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293000317	Outer membrane efflux protein; Region: OEP; pfam02321
886293000318	Outer membrane efflux protein; Region: OEP; pfam02321
886293000319	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
886293000320	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
886293000321	E-class dimer interface [polypeptide binding]; other site
886293000322	P-class dimer interface [polypeptide binding]; other site
886293000323	active site
886293000324	Cu2+ binding site [ion binding]; other site
886293000325	Zn2+ binding site [ion binding]; other site
886293000326	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
886293000327	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
886293000328	active site
886293000329	nucleophile elbow; other site
886293000330	argininosuccinate lyase; Provisional; Region: PRK00855
886293000331	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
886293000332	active sites [active]
886293000333	tetramer interface [polypeptide binding]; other site
886293000334	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
886293000335	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
886293000336	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293000337	Walker A motif; other site
886293000338	ATP binding site [chemical binding]; other site
886293000339	Walker B motif; other site
886293000340	arginine finger; other site
886293000341	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
886293000342	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
886293000343	DNA methylase; Region: N6_N4_Mtase; pfam01555
886293000344	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000345	Protein of unknown function (DUF4058); Region: DUF4058; pfam13267
886293000346	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293000347	S-adenosylmethionine binding site [chemical binding]; other site
886293000348	NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234
886293000349	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293000350	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293000351	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293000352	DNA binding residues [nucleotide binding]
886293000353	gag gene protein p17 (matrix protein); Region: Gag_p17; pfam00540
886293000354	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000355	prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294
886293000356	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
886293000357	homotrimer interaction site [polypeptide binding]; other site
886293000358	putative active site [active]
886293000359	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293000360	Sulfatase; Region: Sulfatase; cl17466
886293000361	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
886293000362	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000363	Response regulator receiver domain; Region: Response_reg; pfam00072
886293000364	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293000365	active site
886293000366	phosphorylation site [posttranslational modification]
886293000367	intermolecular recognition site; other site
886293000368	dimerization interface [polypeptide binding]; other site
886293000369	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
886293000370	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
886293000371	catalytic residue [active]
886293000372	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000373	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293000374	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
886293000375	phosphopeptide binding site; other site
886293000376	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293000377	phosphopeptide binding site; other site
886293000378	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
886293000379	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293000380	phosphopeptide binding site; other site
886293000381	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293000382	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
886293000383	phosphopeptide binding site; other site
886293000384	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
886293000385	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293000386	phosphopeptide binding site; other site
886293000387	Peptidase family M48; Region: Peptidase_M48; cl12018
886293000388	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293000389	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293000390	active site
886293000391	ATP binding site [chemical binding]; other site
886293000392	substrate binding site [chemical binding]; other site
886293000393	activation loop (A-loop); other site
886293000394	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293000395	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
886293000396	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
886293000397	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
886293000398	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
886293000399	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000400	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
886293000401	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
886293000402	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
886293000403	ATP-grasp domain; Region: ATP-grasp_4; cl17255
886293000404	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
886293000405	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
886293000406	ATP-grasp domain; Region: ATP-grasp_4; cl17255
886293000407	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
886293000408	IMP binding site; other site
886293000409	dimer interface [polypeptide binding]; other site
886293000410	interdomain contacts; other site
886293000411	partial ornithine binding site; other site
886293000412	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
886293000413	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
886293000414	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
886293000415	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
886293000416	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
886293000417	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
886293000418	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
886293000419	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
886293000420	Sulfatase; Region: Sulfatase; pfam00884
886293000421	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293000422	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293000423	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293000424	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293000425	DNA binding residues [nucleotide binding]
886293000426	Predicted membrane protein [Function unknown]; Region: COG4655
886293000427	N-acetyltransferase; Region: Acetyltransf_2; pfam00797
886293000428	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
886293000429	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354
886293000430	putative metal binding site [ion binding]; other site
886293000431	Predicted transcriptional regulator [Transcription]; Region: COG2345
886293000432	Transcriptional regulator PadR-like family; Region: PadR; cl17335
886293000433	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
886293000434	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
886293000435	tRNA; other site
886293000436	putative tRNA binding site [nucleotide binding]; other site
886293000437	putative NADP binding site [chemical binding]; other site
886293000438	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
886293000439	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
886293000440	DinB family; Region: DinB; cl17821
886293000441	DinB superfamily; Region: DinB_2; pfam12867
886293000442	multidrug efflux system protein; Provisional; Region: PRK11431
886293000443	polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075
886293000444	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293000445	Walker A/P-loop; other site
886293000446	ATP binding site [chemical binding]; other site
886293000447	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
886293000448	active site
886293000449	metal binding site [ion binding]; metal-binding site
886293000450	RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623
886293000451	3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074
886293000452	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293000453	S-adenosylmethionine binding site [chemical binding]; other site
886293000454	Cupin domain; Region: Cupin_2; pfam07883
886293000455	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
886293000456	Uncharacterized conserved protein [Function unknown]; Region: COG2128
886293000457	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293000458	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
886293000459	Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712
886293000460	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000461	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
886293000462	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
886293000463	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
886293000464	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
886293000465	dimer interface [polypeptide binding]; other site
886293000466	active site
886293000467	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
886293000468	putative active site [active]
886293000469	putative catalytic site [active]
886293000470	Predicted transcriptional regulators [Transcription]; Region: COG1733
886293000471	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
886293000472	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293000473	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293000474	structural tetrad; other site
886293000475	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293000476	structural tetrad; other site
886293000477	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293000478	Caspase domain; Region: Peptidase_C14; pfam00656
886293000479	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293000480	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293000481	active site
886293000482	ATP binding site [chemical binding]; other site
886293000483	substrate binding site [chemical binding]; other site
886293000484	activation loop (A-loop); other site
886293000485	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293000486	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
886293000487	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
886293000488	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
886293000489	catalytic residue [active]
886293000490	RloB-like protein; Region: RloB; pfam13707
886293000491	AAA domain; Region: AAA_21; pfam13304
886293000492	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293000493	ABC transporter signature motif; other site
886293000494	Walker B; other site
886293000495	D-loop; other site
886293000496	H-loop/switch region; other site
886293000497	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
886293000498	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293000499	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293000500	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
886293000501	DNA binding residues [nucleotide binding]
886293000502	Pectic acid lyase; Region: Pec_lyase; pfam09492
886293000503	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
886293000504	xanthine dehydrogenase; Region: PLN02906
886293000505	catalytic loop [active]
886293000506	iron binding site [ion binding]; other site
886293000507	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
886293000508	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
886293000509	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
886293000510	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
886293000511	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
886293000512	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
886293000513	Ligand Binding Site [chemical binding]; other site
886293000514	RNA polymerase beta' subunit; Region: rpoC1; CHL00018
886293000515	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
886293000516	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293000517	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293000518	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293000519	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293000520	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293000521	Penicillinase repressor; Region: Pencillinase_R; pfam03965
886293000522	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
886293000523	putative catalytic site [active]
886293000524	putative metal binding site [ion binding]; other site
886293000525	putative phosphate binding site [ion binding]; other site
886293000526	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
886293000527	N- and C-terminal domain interface [polypeptide binding]; other site
886293000528	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
886293000529	active site
886293000530	putative catalytic site [active]
886293000531	metal binding site [ion binding]; metal-binding site
886293000532	ATP binding site [chemical binding]; other site
886293000533	carbohydrate binding site [chemical binding]; other site
886293000534	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293000535	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
886293000536	NADP-binding site; other site
886293000537	homotetramer interface [polypeptide binding]; other site
886293000538	substrate binding site [chemical binding]; other site
886293000539	homodimer interface [polypeptide binding]; other site
886293000540	active site
886293000541	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
886293000542	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
886293000543	Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316
886293000544	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
886293000545	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
886293000546	active site
886293000547	dimer interface [polypeptide binding]; other site
886293000548	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
886293000549	Ligand Binding Site [chemical binding]; other site
886293000550	Molecular Tunnel; other site
886293000551	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293000552	dimerization interface [polypeptide binding]; other site
886293000553	putative DNA binding site [nucleotide binding]; other site
886293000554	putative Zn2+ binding site [ion binding]; other site
886293000555	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
886293000556	SdpI/YhfL protein family; Region: SdpI; pfam13630
886293000557	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
886293000558	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293000559	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
886293000560	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000561	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
886293000562	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
886293000563	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
886293000564	putative active site [active]
886293000565	catalytic site [active]
886293000566	putative metal binding site [ion binding]; other site
886293000567	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
886293000568	active site
886293000569	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
886293000570	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
886293000571	ligand binding site; other site
886293000572	oligomer interface; other site
886293000573	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
886293000574	dimer interface [polypeptide binding]; other site
886293000575	N-terminal domain interface [polypeptide binding]; other site
886293000576	sulfate 1 binding site; other site
886293000577	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
886293000578	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
886293000579	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000580	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293000581	active site
886293000582	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293000583	phosphorylation site [posttranslational modification]
886293000584	intermolecular recognition site; other site
886293000585	dimerization interface [polypeptide binding]; other site
886293000586	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293000587	dimer interface [polypeptide binding]; other site
886293000588	phosphorylation site [posttranslational modification]
886293000589	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293000590	ATP binding site [chemical binding]; other site
886293000591	Mg2+ binding site [ion binding]; other site
886293000592	G-X-G motif; other site
886293000593	Response regulator receiver domain; Region: Response_reg; pfam00072
886293000594	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293000595	active site
886293000596	phosphorylation site [posttranslational modification]
886293000597	intermolecular recognition site; other site
886293000598	dimerization interface [polypeptide binding]; other site
886293000599	CheB methylesterase; Region: CheB_methylest; pfam01339
886293000600	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
886293000601	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
886293000602	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
886293000603	CHASE3 domain; Region: CHASE3; pfam05227
886293000604	GAF domain; Region: GAF_3; pfam13492
886293000605	GAF domain; Region: GAF_2; pfam13185
886293000606	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293000607	dimer interface [polypeptide binding]; other site
886293000608	phosphorylation site [posttranslational modification]
886293000609	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293000610	ATP binding site [chemical binding]; other site
886293000611	Mg2+ binding site [ion binding]; other site
886293000612	G-X-G motif; other site
886293000613	Response regulator receiver domain; Region: Response_reg; pfam00072
886293000614	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293000615	active site
886293000616	phosphorylation site [posttranslational modification]
886293000617	intermolecular recognition site; other site
886293000618	dimerization interface [polypeptide binding]; other site
886293000619	Response regulator receiver domain; Region: Response_reg; pfam00072
886293000620	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293000621	active site
886293000622	phosphorylation site [posttranslational modification]
886293000623	intermolecular recognition site; other site
886293000624	dimerization interface [polypeptide binding]; other site
886293000625	Response regulator receiver domain; Region: Response_reg; pfam00072
886293000626	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293000627	active site
886293000628	phosphorylation site [posttranslational modification]
886293000629	intermolecular recognition site; other site
886293000630	dimerization interface [polypeptide binding]; other site
886293000631	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
886293000632	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293000633	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
886293000634	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
886293000635	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
886293000636	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
886293000637	metal ion-dependent adhesion site (MIDAS); other site
886293000638	tail sheath protein; Provisional; Region: 18; PHA02539
886293000639	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
886293000640	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
886293000641	DDE superfamily endonuclease; Region: DDE_5; pfam13546
886293000642	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
886293000643	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293000644	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293000645	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293000646	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
886293000647	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000648	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
886293000649	GAF domain; Region: GAF_2; pfam13185
886293000650	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
886293000651	PAS domain; Region: PAS; smart00091
886293000652	PAS domain; Region: PAS_9; pfam13426
886293000653	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
886293000654	GAF domain; Region: GAF; pfam01590
886293000655	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
886293000656	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
886293000657	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
886293000658	dimer interface [polypeptide binding]; other site
886293000659	putative CheW interface [polypeptide binding]; other site
886293000660	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
886293000661	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
886293000662	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
886293000663	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
886293000664	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
886293000665	putative binding surface; other site
886293000666	active site
886293000667	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
886293000668	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293000669	ATP binding site [chemical binding]; other site
886293000670	Mg2+ binding site [ion binding]; other site
886293000671	G-X-G motif; other site
886293000672	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
886293000673	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
886293000674	CheD chemotactic sensory transduction; Region: CheD; cl00810
886293000675	Response regulator receiver domain; Region: Response_reg; pfam00072
886293000676	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293000677	active site
886293000678	phosphorylation site [posttranslational modification]
886293000679	intermolecular recognition site; other site
886293000680	dimerization interface [polypeptide binding]; other site
886293000681	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
886293000682	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293000683	active site
886293000684	phosphorylation site [posttranslational modification]
886293000685	intermolecular recognition site; other site
886293000686	dimerization interface [polypeptide binding]; other site
886293000687	CheB methylesterase; Region: CheB_methylest; pfam01339
886293000688	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000689	prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294
886293000690	metal-dependent hydrolase; Provisional; Region: PRK00685
886293000691	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
886293000692	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
886293000693	putative trimer interface [polypeptide binding]; other site
886293000694	putative CoA binding site [chemical binding]; other site
886293000695	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
886293000696	putative trimer interface [polypeptide binding]; other site
886293000697	putative CoA binding site [chemical binding]; other site
886293000698	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
886293000699	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
886293000700	putative ADP-binding pocket [chemical binding]; other site
886293000701	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293000702	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293000703	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
886293000704	active site
886293000705	TPR repeat; Region: TPR_11; pfam13414
886293000706	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293000707	binding surface
886293000708	TPR motif; other site
886293000709	TPR repeat; Region: TPR_11; pfam13414
886293000710	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293000711	binding surface
886293000712	TPR motif; other site
886293000713	TPR repeat; Region: TPR_11; pfam13414
886293000714	TPR repeat; Region: TPR_11; pfam13414
886293000715	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293000716	binding surface
886293000717	TPR motif; other site
886293000718	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293000719	binding surface
886293000720	TPR motif; other site
886293000721	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
886293000722	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293000723	binding surface
886293000724	TPR motif; other site
886293000725	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293000726	binding surface
886293000727	TPR motif; other site
886293000728	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293000729	binding surface
886293000730	TPR motif; other site
886293000731	TPR repeat; Region: TPR_11; pfam13414
886293000732	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293000733	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293000734	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293000735	DNA binding residues [nucleotide binding]
886293000736	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
886293000737	Class I aldolases; Region: Aldolase_Class_I; cl17187
886293000738	catalytic residue [active]
886293000739	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
886293000740	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
886293000741	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
886293000742	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
886293000743	putative active site [active]
886293000744	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
886293000745	oligosaccharide amylase; Region: oligosac_amyl; TIGR01577
886293000746	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293000747	TPR motif; other site
886293000748	binding surface
886293000749	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
886293000750	TPR repeat; Region: TPR_11; pfam13414
886293000751	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293000752	TPR motif; other site
886293000753	binding surface
886293000754	TPR repeat; Region: TPR_11; pfam13414
886293000755	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293000756	Calx-beta domain; Region: Calx-beta; cl02522
886293000757	RHS Repeat; Region: RHS_repeat; cl11982
886293000758	RHS Repeat; Region: RHS_repeat; pfam05593
886293000759	RHS Repeat; Region: RHS_repeat; pfam05593
886293000760	RHS Repeat; Region: RHS_repeat; pfam05593
886293000761	Family description; Region: VCBS; pfam13517
886293000762	Family description; Region: VCBS; pfam13517
886293000763	RHS Repeat; Region: RHS_repeat; pfam05593
886293000764	RHS Repeat; Region: RHS_repeat; pfam05593
886293000765	RHS Repeat; Region: RHS_repeat; pfam05593
886293000766	RHS Repeat; Region: RHS_repeat; pfam05593
886293000767	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
886293000768	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
886293000769	RHS Repeat; Region: RHS_repeat; pfam05593
886293000770	RHS Repeat; Region: RHS_repeat; pfam05593
886293000771	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
886293000772	RHS Repeat; Region: RHS_repeat; pfam05593
886293000773	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
886293000774	RHS Repeat; Region: RHS_repeat; pfam05593
886293000775	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
886293000776	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
886293000777	RHS Repeat; Region: RHS_repeat; pfam05593
886293000778	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
886293000779	Homeodomain-like domain; Region: HTH_23; pfam13384
886293000780	Winged helix-turn helix; Region: HTH_29; pfam13551
886293000781	Homeodomain-like domain; Region: HTH_32; pfam13565
886293000782	DDE superfamily endonuclease; Region: DDE_3; pfam13358
886293000783	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
886293000784	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
886293000785	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
886293000786	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
886293000787	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
886293000788	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
886293000789	Cadherin repeat-like domain; Region: CA_like; cl15786
886293000790	Ca2+ binding site [ion binding]; other site
886293000791	Family description; Region: VCBS; pfam13517
886293000792	Family description; Region: VCBS; pfam13517
886293000793	Family description; Region: VCBS; pfam13517
886293000794	Family description; Region: VCBS; pfam13517
886293000795	RHS Repeat; Region: RHS_repeat; pfam05593
886293000796	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
886293000797	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
886293000798	RHS Repeat; Region: RHS_repeat; pfam05593
886293000799	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
886293000800	RHS Repeat; Region: RHS_repeat; pfam05593
886293000801	RHS Repeat; Region: RHS_repeat; pfam05593
886293000802	RHS Repeat; Region: RHS_repeat; pfam05593
886293000803	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
886293000804	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
886293000805	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
886293000806	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293000807	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293000808	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
886293000809	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
886293000810	Probable Catalytic site; other site
886293000811	metal-binding site
886293000812	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293000813	active site
886293000814	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293000815	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
886293000816	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
886293000817	putative metal binding site; other site
886293000818	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
886293000819	binding surface
886293000820	TPR motif; other site
886293000821	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293000822	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
886293000823	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000824	Transcriptional regulator [Transcription]; Region: LysR; COG0583
886293000825	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
886293000826	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
886293000827	dimerization interface [polypeptide binding]; other site
886293000828	Predicted amidohydrolase [General function prediction only]; Region: COG0388
886293000829	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
886293000830	active site
886293000831	catalytic triad [active]
886293000832	dimer interface [polypeptide binding]; other site
886293000833	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293000834	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
886293000835	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
886293000836	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
886293000837	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
886293000838	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
886293000839	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
886293000840	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl11892
886293000841	CRISPR/Cas system-associated protein Cas8c' Region: Cas8c'_I-D; cl11893
886293000842	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
886293000843	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
886293000844	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
886293000845	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl09782
886293000846	Predicted transcriptional regulator [Transcription]; Region: COG2378
886293000847	WYL domain; Region: WYL; pfam13280
886293000848	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
886293000849	classical (c) SDRs; Region: SDR_c; cd05233
886293000850	NAD(P) binding site [chemical binding]; other site
886293000851	active site
886293000852	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
886293000853	HEAT repeats; Region: HEAT_2; pfam13646
886293000854	HEAT repeats; Region: HEAT_2; pfam13646
886293000855	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
886293000856	catalytic site [active]
886293000857	BNR repeat-like domain; Region: BNR_2; pfam13088
886293000858	Asp-box motif; other site
886293000859	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
886293000860	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
886293000861	NHL repeat; Region: NHL; pfam01436
886293000862	NHL repeat; Region: NHL; pfam01436
886293000863	NHL repeat; Region: NHL; pfam01436
886293000864	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293000865	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293000866	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293000867	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293000868	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
886293000869	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
886293000870	Kelch motif; Region: Kelch_5; pfam13854
886293000871	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
886293000872	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
886293000873	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
886293000874	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
886293000875	active site
886293000876	Zn binding site [ion binding]; other site
886293000877	BNR repeat-like domain; Region: BNR_2; pfam13088
886293000878	Abhydrolase family; Region: Abhydrolase_7; pfam12715
886293000879	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
886293000880	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939
886293000881	Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231
886293000882	catalytic Zn binding site [ion binding]; other site
886293000883	putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366
886293000884	structural Zn binding site [ion binding]; other site
886293000885	tetramer interface [polypeptide binding]; other site
886293000886	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
886293000887	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
886293000888	hydroxyglutarate oxidase; Provisional; Region: PRK11728
886293000889	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
886293000890	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293000891	motif II; other site
886293000892	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
886293000893	Fatty acid desaturase; Region: FA_desaturase; pfam00487
886293000894	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
886293000895	putative di-iron ligands [ion binding]; other site
886293000896	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
886293000897	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
886293000898	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
886293000899	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
886293000900	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
886293000901	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
886293000902	metal ion-dependent adhesion site (MIDAS); other site
886293000903	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
886293000904	Protein of unknown function DUF58; Region: DUF58; pfam01882
886293000905	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
886293000906	metal ion-dependent adhesion site (MIDAS); other site
886293000907	MoxR-like ATPases [General function prediction only]; Region: COG0714
886293000908	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293000909	Walker A motif; other site
886293000910	ATP binding site [chemical binding]; other site
886293000911	Walker B motif; other site
886293000912	arginine finger; other site
886293000913	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
886293000914	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293000915	binding surface
886293000916	TPR motif; other site
886293000917	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
886293000918	TPR repeat; Region: TPR_11; pfam13414
886293000919	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
886293000920	binding surface
886293000921	TPR motif; other site
886293000922	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000923	prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294
886293000924	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293000925	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293000926	active site
886293000927	ATP binding site [chemical binding]; other site
886293000928	substrate binding site [chemical binding]; other site
886293000929	activation loop (A-loop); other site
886293000930	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293000931	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293000932	structural tetrad; other site
886293000933	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293000934	structural tetrad; other site
886293000935	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293000936	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293000937	structural tetrad; other site
886293000938	WD domain, G-beta repeat; Region: WD40; pfam00400
886293000939	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293000940	Predicted membrane protein [Function unknown]; Region: COG3503
886293000941	universal stress protein UspE; Provisional; Region: PRK11175
886293000942	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
886293000943	Ligand Binding Site [chemical binding]; other site
886293000944	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
886293000945	Ligand Binding Site [chemical binding]; other site
886293000946	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000947	Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372
886293000948	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
886293000949	catalytic residue [active]
886293000950	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
886293000951	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
886293000952	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
886293000953	inhibitor-cofactor binding pocket; inhibition site
886293000954	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293000955	catalytic residue [active]
886293000956	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
886293000957	active site
886293000958	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
886293000959	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
886293000960	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293000961	active site
886293000962	phosphorylation site [posttranslational modification]
886293000963	intermolecular recognition site; other site
886293000964	dimerization interface [polypeptide binding]; other site
886293000965	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
886293000966	DNA binding site [nucleotide binding]
886293000967	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
886293000968	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
886293000969	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293000970	dimer interface [polypeptide binding]; other site
886293000971	phosphorylation site [posttranslational modification]
886293000972	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293000973	ATP binding site [chemical binding]; other site
886293000974	Mg2+ binding site [ion binding]; other site
886293000975	G-X-G motif; other site
886293000976	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424
886293000977	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
886293000978	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293000979	Walker A motif; other site
886293000980	ATP binding site [chemical binding]; other site
886293000981	Walker B motif; other site
886293000982	arginine finger; other site
886293000983	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
886293000984	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370
886293000985	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293000986	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293000987	HEAT repeats; Region: HEAT_2; pfam13646
886293000988	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293000989	Cytochrome c; Region: Cytochrom_C; pfam00034
886293000990	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293000991	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293000992	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
886293000993	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293000994	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293000995	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293000996	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293000997	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
886293000998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293000999	active site
886293001000	phosphorylation site [posttranslational modification]
886293001001	intermolecular recognition site; other site
886293001002	dimerization interface [polypeptide binding]; other site
886293001003	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
886293001004	DNA binding residues [nucleotide binding]
886293001005	dimerization interface [polypeptide binding]; other site
886293001006	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
886293001007	Histidine kinase; Region: HisKA_3; pfam07730
886293001008	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293001009	ATP binding site [chemical binding]; other site
886293001010	Mg2+ binding site [ion binding]; other site
886293001011	G-X-G motif; other site
886293001012	Protein of unknown function (DUF1264); Region: DUF1264; pfam06884
886293001013	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
886293001014	active site residue [active]
886293001015	Rhomboid family; Region: Rhomboid; pfam01694
886293001016	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
886293001017	Amidohydrolase; Region: Amidohydro_2; pfam04909
886293001018	active site
886293001019	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293001020	Family description; Region: VCBS; pfam13517
886293001021	Family description; Region: VCBS; pfam13517
886293001022	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
886293001023	RHS Repeat; Region: RHS_repeat; cl11982
886293001024	RHS Repeat; Region: RHS_repeat; pfam05593
886293001025	RHS Repeat; Region: RHS_repeat; pfam05593
886293001026	RHS Repeat; Region: RHS_repeat; pfam05593
886293001027	RHS Repeat; Region: RHS_repeat; pfam05593
886293001028	RHS Repeat; Region: RHS_repeat; pfam05593
886293001029	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
886293001030	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
886293001031	RHS Repeat; Region: RHS_repeat; pfam05593
886293001032	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
886293001033	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
886293001034	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
886293001035	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
886293001036	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
886293001037	putative active site [active]
886293001038	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
886293001039	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
886293001040	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293001041	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293001042	Uncharacterized conserved protein [Function unknown]; Region: COG3379
886293001043	Ribosome-binding factor A; Region: RBFA; cl00542
886293001044	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
886293001045	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
886293001046	putative active site [active]
886293001047	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
886293001048	HIT family signature motif; other site
886293001049	catalytic residue [active]
886293001050	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
886293001051	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
886293001052	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
886293001053	alphaNTD homodimer interface [polypeptide binding]; other site
886293001054	alphaNTD - beta interaction site [polypeptide binding]; other site
886293001055	alphaNTD - beta' interaction site [polypeptide binding]; other site
886293001056	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
886293001057	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
886293001058	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
886293001059	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
886293001060	RNA binding surface [nucleotide binding]; other site
886293001061	30S ribosomal protein S11; Validated; Region: PRK05309
886293001062	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
886293001063	30S ribosomal protein S13; Region: bact_S13; TIGR03631
886293001064	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
886293001065	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
886293001066	active site
886293001067	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
886293001068	SecY translocase; Region: SecY; pfam00344
886293001069	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
886293001070	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
886293001071	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
886293001072	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
886293001073	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
886293001074	23S rRNA interface [nucleotide binding]; other site
886293001075	5S rRNA interface [nucleotide binding]; other site
886293001076	L27 interface [polypeptide binding]; other site
886293001077	L5 interface [polypeptide binding]; other site
886293001078	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
886293001079	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
886293001080	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
886293001081	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
886293001082	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
886293001083	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
886293001084	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
886293001085	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
886293001086	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
886293001087	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
886293001088	RNA binding site [nucleotide binding]; other site
886293001089	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
886293001090	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
886293001091	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
886293001092	23S rRNA interface [nucleotide binding]; other site
886293001093	putative translocon interaction site; other site
886293001094	signal recognition particle (SRP54) interaction site; other site
886293001095	L23 interface [polypeptide binding]; other site
886293001096	trigger factor interaction site; other site
886293001097	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
886293001098	23S rRNA interface [nucleotide binding]; other site
886293001099	5S rRNA interface [nucleotide binding]; other site
886293001100	putative antibiotic binding site [chemical binding]; other site
886293001101	L25 interface [polypeptide binding]; other site
886293001102	L27 interface [polypeptide binding]; other site
886293001103	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
886293001104	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
886293001105	G-X-X-G motif; other site
886293001106	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
886293001107	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
886293001108	protein-rRNA interface [nucleotide binding]; other site
886293001109	putative translocon binding site; other site
886293001110	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
886293001111	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
886293001112	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
886293001113	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
886293001114	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
886293001115	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
886293001116	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
886293001117	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
886293001118	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
886293001119	putative active site [active]
886293001120	elongation factor G; Reviewed; Region: PRK00007
886293001121	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
886293001122	G1 box; other site
886293001123	putative GEF interaction site [polypeptide binding]; other site
886293001124	GTP/Mg2+ binding site [chemical binding]; other site
886293001125	Switch I region; other site
886293001126	G2 box; other site
886293001127	G3 box; other site
886293001128	Switch II region; other site
886293001129	G4 box; other site
886293001130	G5 box; other site
886293001131	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
886293001132	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
886293001133	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
886293001134	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
886293001135	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
886293001136	Beta-lactamase; Region: Beta-lactamase; pfam00144
886293001137	30S ribosomal protein S7; Validated; Region: PRK05302
886293001138	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
886293001139	S17 interaction site [polypeptide binding]; other site
886293001140	S8 interaction site; other site
886293001141	16S rRNA interaction site [nucleotide binding]; other site
886293001142	streptomycin interaction site [chemical binding]; other site
886293001143	23S rRNA interaction site [nucleotide binding]; other site
886293001144	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
886293001145	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293001146	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
886293001147	hypothetical protein; Provisional; Region: PRK02237
886293001148	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
886293001149	active site
886293001150	Fe-S cluster binding site [ion binding]; other site
886293001151	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
886293001152	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
886293001153	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
886293001154	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
886293001155	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
886293001156	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
886293001157	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
886293001158	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
886293001159	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
886293001160	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
886293001161	DNA binding site [nucleotide binding]
886293001162	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
886293001163	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
886293001164	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
886293001165	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
886293001166	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
886293001167	RPB11 interaction site [polypeptide binding]; other site
886293001168	RPB12 interaction site [polypeptide binding]; other site
886293001169	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
886293001170	RPB3 interaction site [polypeptide binding]; other site
886293001171	RPB1 interaction site [polypeptide binding]; other site
886293001172	RPB11 interaction site [polypeptide binding]; other site
886293001173	RPB10 interaction site [polypeptide binding]; other site
886293001174	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
886293001175	peripheral dimer interface [polypeptide binding]; other site
886293001176	core dimer interface [polypeptide binding]; other site
886293001177	L10 interface [polypeptide binding]; other site
886293001178	L11 interface [polypeptide binding]; other site
886293001179	putative EF-Tu interaction site [polypeptide binding]; other site
886293001180	putative EF-G interaction site [polypeptide binding]; other site
886293001181	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
886293001182	23S rRNA interface [nucleotide binding]; other site
886293001183	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
886293001184	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
886293001185	mRNA/rRNA interface [nucleotide binding]; other site
886293001186	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
886293001187	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
886293001188	23S rRNA interface [nucleotide binding]; other site
886293001189	L7/L12 interface [polypeptide binding]; other site
886293001190	putative thiostrepton binding site; other site
886293001191	L25 interface [polypeptide binding]; other site
886293001192	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
886293001193	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
886293001194	putative homodimer interface [polypeptide binding]; other site
886293001195	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
886293001196	heterodimer interface [polypeptide binding]; other site
886293001197	homodimer interface [polypeptide binding]; other site
886293001198	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
886293001199	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
886293001200	elongation factor Tu; Reviewed; Region: PRK00049
886293001201	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
886293001202	G1 box; other site
886293001203	GEF interaction site [polypeptide binding]; other site
886293001204	GTP/Mg2+ binding site [chemical binding]; other site
886293001205	Switch I region; other site
886293001206	G2 box; other site
886293001207	G3 box; other site
886293001208	Switch II region; other site
886293001209	G4 box; other site
886293001210	G5 box; other site
886293001211	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
886293001212	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
886293001213	Antibiotic Binding Site [chemical binding]; other site
886293001214	Helix-turn-helix domain; Region: HTH_17; pfam12728
886293001215	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; Region: RpoD; COG0568
886293001216	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293001217	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293001218	DNA binding residues [nucleotide binding]
886293001219	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293001220	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
886293001221	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
886293001222	catalytic residues [active]
886293001223	catalytic nucleophile [active]
886293001224	Recombinase; Region: Recombinase; pfam07508
886293001225	Homeodomain-like domain; Region: HTH_23; pfam13384
886293001226	Winged helix-turn helix; Region: HTH_29; pfam13551
886293001227	Homeodomain-like domain; Region: HTH_32; pfam13565
886293001228	DDE superfamily endonuclease; Region: DDE_3; pfam13358
886293001229	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
886293001230	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
886293001231	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
886293001232	RibD C-terminal domain; Region: RibD_C; cl17279
886293001233	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
886293001234	active site
886293001235	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
886293001236	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293001237	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
886293001238	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
886293001239	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293001240	non-specific DNA binding site [nucleotide binding]; other site
886293001241	salt bridge; other site
886293001242	sequence-specific DNA binding site [nucleotide binding]; other site
886293001243	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
886293001244	dimer interface [polypeptide binding]; other site
886293001245	active site
886293001246	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
886293001247	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293001248	motif II; other site
886293001249	Uncharacterized conserved protein [Function unknown]; Region: COG1915
886293001250	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
886293001251	substrate binding site [chemical binding]; other site
886293001252	ATP binding site [chemical binding]; other site
886293001253	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
886293001254	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293001255	Coenzyme A binding pocket [chemical binding]; other site
886293001256	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
886293001257	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
886293001258	active site
886293001259	DNA binding site [nucleotide binding]
886293001260	Protein of unknown function DUF72; Region: DUF72; pfam01904
886293001261	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
886293001262	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
886293001263	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
886293001264	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
886293001265	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293001266	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
886293001267	phosphopeptide binding site; other site
886293001268	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293001269	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293001270	active site
886293001271	ATP binding site [chemical binding]; other site
886293001272	substrate binding site [chemical binding]; other site
886293001273	activation loop (A-loop); other site
886293001274	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293001275	Sulfatase; Region: Sulfatase; pfam00884
886293001276	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293001277	Putative molybdenum carrier; Region: MoCo_carrier; pfam12694
886293001278	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
886293001279	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
886293001280	Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440
886293001281	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
886293001282	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
886293001283	Cu(I) binding site [ion binding]; other site
886293001284	56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694
886293001285	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
886293001286	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
886293001287	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
886293001288	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
886293001289	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
886293001290	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
886293001291	S-adenosylmethionine synthetase; Validated; Region: PRK05250
886293001292	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
886293001293	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
886293001294	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
886293001295	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293001296	Tetratricopeptide repeat; Region: TPR_16; pfam13432
886293001297	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293001298	TPR motif; other site
886293001299	binding surface
886293001300	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
886293001301	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
886293001302	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293001303	TPR motif; other site
886293001304	binding surface
886293001305	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
886293001306	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
886293001307	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
886293001308	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535
886293001309	metal binding site [ion binding]; metal-binding site
886293001310	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
886293001311	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
886293001312	Walker A/P-loop; other site
886293001313	ATP binding site [chemical binding]; other site
886293001314	Q-loop/lid; other site
886293001315	ABC transporter signature motif; other site
886293001316	Walker B; other site
886293001317	D-loop; other site
886293001318	H-loop/switch region; other site
886293001319	hypothetical protein; Provisional; Region: PRK08912
886293001320	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
886293001321	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293001322	homodimer interface [polypeptide binding]; other site
886293001323	catalytic residue [active]
886293001324	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
886293001325	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cd02106
886293001326	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
886293001327	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
886293001328	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
886293001329	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
886293001330	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
886293001331	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
886293001332	putative NAD(P) binding site [chemical binding]; other site
886293001333	putative substrate binding site [chemical binding]; other site
886293001334	catalytic Zn binding site [ion binding]; other site
886293001335	structural Zn binding site [ion binding]; other site
886293001336	dimer interface [polypeptide binding]; other site
886293001337	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
886293001338	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
886293001339	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
886293001340	dimerization interface [polypeptide binding]; other site
886293001341	NAD binding site [chemical binding]; other site
886293001342	ligand binding site [chemical binding]; other site
886293001343	catalytic site [active]
886293001344	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
886293001345	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293001346	NAD(P) binding site [chemical binding]; other site
886293001347	active site
886293001348	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
886293001349	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
886293001350	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
886293001351	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
886293001352	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
886293001353	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
886293001354	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
886293001355	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
886293001356	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
886293001357	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
886293001358	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
886293001359	Predicted membrane protein [Function unknown]; Region: COG2323
886293001360	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
886293001361	HEAT repeats; Region: HEAT_2; pfam13646
886293001362	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
886293001363	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293001364	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293001365	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
886293001366	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
886293001367	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
886293001368	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
886293001369	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
886293001370	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
886293001371	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293001372	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293001373	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293001374	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293001375	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293001376	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293001377	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293001378	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
886293001379	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
886293001380	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
886293001381	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
886293001382	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
886293001383	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
886293001384	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
886293001385	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293001386	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
886293001387	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
886293001388	Walker A/P-loop; other site
886293001389	ATP binding site [chemical binding]; other site
886293001390	Q-loop/lid; other site
886293001391	ABC transporter signature motif; other site
886293001392	Walker B; other site
886293001393	D-loop; other site
886293001394	H-loop/switch region; other site
886293001395	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
886293001396	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
886293001397	dimer interface [polypeptide binding]; other site
886293001398	conserved gate region; other site
886293001399	putative PBP binding loops; other site
886293001400	ABC-ATPase subunit interface; other site
886293001401	sulfate transport protein; Provisional; Region: cysT; CHL00187
886293001402	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
886293001403	dimer interface [polypeptide binding]; other site
886293001404	conserved gate region; other site
886293001405	putative PBP binding loops; other site
886293001406	ABC-ATPase subunit interface; other site
886293001407	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
886293001408	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
886293001409	Predicted transcriptional regulator [Transcription]; Region: COG1959
886293001410	Transcriptional regulator; Region: Rrf2; cl17282
886293001411	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
886293001412	Protein of unknown function, DUF393; Region: DUF393; pfam04134
886293001413	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
886293001414	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
886293001415	Ligand binding site; other site
886293001416	Putative Catalytic site; other site
886293001417	DXD motif; other site
886293001418	Methyltransferase domain; Region: Methyltransf_31; pfam13847
886293001419	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293001420	S-adenosylmethionine binding site [chemical binding]; other site
886293001421	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
886293001422	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
886293001423	RNA binding surface [nucleotide binding]; other site
886293001424	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
886293001425	active site
886293001426	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
886293001427	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
886293001428	active site
886293001429	Domain of unknown function (DUF4188); Region: DUF4188; pfam13826
886293001430	Protein of unknown function (DUF1569); Region: DUF1569; pfam07606
886293001431	Domain of unknown function (DUF427); Region: DUF427; cl00998
886293001432	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293001433	Sulfatase; Region: Sulfatase; pfam00884
886293001434	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293001435	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293001436	Bax inhibitor 1 like; Region: BaxI_1; cl17691
886293001437	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293001438	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
886293001439	Methyltransferase domain; Region: Methyltransf_23; pfam13489
886293001440	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293001441	S-adenosylmethionine binding site [chemical binding]; other site
886293001442	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
886293001443	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
886293001444	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
886293001445	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
886293001446	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
886293001447	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
886293001448	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293001449	Interdomain contacts; other site
886293001450	Cytokine receptor motif; other site
886293001451	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
886293001452	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
886293001453	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
886293001454	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
886293001455	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
886293001456	catalytic residue [active]
886293001457	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293001458	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293001459	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
886293001460	Class I aldolases; Region: Aldolase_Class_I; cl17187
886293001461	catalytic residue [active]
886293001462	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
886293001463	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293001464	active site
886293001465	Protein of unknown function (DUF3050); Region: DUF3050; pfam11251
886293001466	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
886293001467	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
886293001468	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
886293001469	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
886293001470	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
886293001471	RNA binding site [nucleotide binding]; other site
886293001472	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
886293001473	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
886293001474	FtsX-like permease family; Region: FtsX; pfam02687
886293001475	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
886293001476	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
886293001477	Walker A/P-loop; other site
886293001478	ATP binding site [chemical binding]; other site
886293001479	Q-loop/lid; other site
886293001480	ABC transporter signature motif; other site
886293001481	Walker B; other site
886293001482	D-loop; other site
886293001483	H-loop/switch region; other site
886293001484	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
886293001485	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
886293001486	NAD(P) binding site [chemical binding]; other site
886293001487	Family description; Region: VCBS; pfam13517
886293001488	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
886293001489	Family description; Region: VCBS; pfam13517
886293001490	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
886293001491	dimerization interface [polypeptide binding]; other site
886293001492	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293001493	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
886293001494	putative deacylase active site [active]
886293001495	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293001496	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
886293001497	catalytic triad [active]
886293001498	putative active site [active]
886293001499	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
886293001500	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
886293001501	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
886293001502	nickel responsive regulator; Provisional; Region: PRK04460
886293001503	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
886293001504	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293001505	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293001506	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293001507	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293001508	Sulfatase; Region: Sulfatase; pfam00884
886293001509	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293001510	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293001511	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293001512	Transmembrane proteins 14C; Region: Tmemb_14; pfam03647
886293001513	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293001514	S-adenosylmethionine binding site [chemical binding]; other site
886293001515	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
886293001516	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
886293001517	dimer interface [polypeptide binding]; other site
886293001518	putative functional site; other site
886293001519	putative MPT binding site; other site
886293001520	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293001521	S-adenosylmethionine binding site [chemical binding]; other site
886293001522	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293001523	TPR motif; other site
886293001524	TPR repeat; Region: TPR_11; pfam13414
886293001525	binding surface
886293001526	MULE transposase domain; Region: MULE; pfam10551
886293001527	HTH-like domain; Region: HTH_21; pfam13276
886293001528	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
886293001529	Integrase core domain; Region: rve; pfam00665
886293001530	Integrase core domain; Region: rve_3; pfam13683
886293001531	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
886293001532	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
886293001533	metal ion-dependent adhesion site (MIDAS); other site
886293001534	tail sheath protein; Provisional; Region: 18; PHA02539
886293001535	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
886293001536	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
886293001537	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293001538	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293001539	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293001540	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
886293001541	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
886293001542	active site
886293001543	metal binding site [ion binding]; metal-binding site
886293001544	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
886293001545	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
886293001546	active site
886293001547	metal binding site [ion binding]; metal-binding site
886293001548	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
886293001549	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
886293001550	acyl-activating enzyme (AAE) consensus motif; other site
886293001551	AMP binding site [chemical binding]; other site
886293001552	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
886293001553	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293001554	non-specific DNA binding site [nucleotide binding]; other site
886293001555	salt bridge; other site
886293001556	sequence-specific DNA binding site [nucleotide binding]; other site
886293001557	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
886293001558	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
886293001559	putative dimer interface [polypeptide binding]; other site
886293001560	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293001561	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
886293001562	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
886293001563	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
886293001564	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
886293001565	protein binding site [polypeptide binding]; other site
886293001566	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
886293001567	Active site serine [active]
886293001568	Uncharacterized conserved protein [Function unknown]; Region: COG3391
886293001569	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
886293001570	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
886293001571	Cytochrome c; Region: Cytochrom_C; cl11414
886293001572	Cytochrome c; Region: Cytochrom_C; pfam00034
886293001573	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
886293001574	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
886293001575	Walker A/P-loop; other site
886293001576	ATP binding site [chemical binding]; other site
886293001577	Q-loop/lid; other site
886293001578	ABC transporter signature motif; other site
886293001579	Walker B; other site
886293001580	D-loop; other site
886293001581	H-loop/switch region; other site
886293001582	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
886293001583	extended (e) SDRs; Region: SDR_e; cd08946
886293001584	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293001585	NAD(P) binding site [chemical binding]; other site
886293001586	active site
886293001587	substrate binding site [chemical binding]; other site
886293001588	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
886293001589	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
886293001590	FAD binding domain; Region: FAD_binding_4; pfam01565
886293001591	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
886293001592	Cysteine-rich domain; Region: CCG; pfam02754
886293001593	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
886293001594	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
886293001595	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
886293001596	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
886293001597	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
886293001598	heterodimer interface [polypeptide binding]; other site
886293001599	active site
886293001600	FMN binding site [chemical binding]; other site
886293001601	homodimer interface [polypeptide binding]; other site
886293001602	substrate binding site [chemical binding]; other site
886293001603	Putative methyltransferase; Region: Methyltransf_16; pfam10294
886293001604	Protein of unknown function (DUF2012); Region: DUF2012; pfam09430
886293001605	Iron permease FTR1 family; Region: FTR1; cl00475
886293001606	Fe2+ transport protein; Region: Iron_transport; pfam10634
886293001607	Sulfatase; Region: Sulfatase; cl17466
886293001608	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293001609	Sulfatase; Region: Sulfatase; cl17466
886293001610	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
886293001611	twin arginine translocase protein A; Provisional; Region: tatA; PRK00191
886293001612	twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411
886293001613	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
886293001614	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
886293001615	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
886293001616	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
886293001617	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
886293001618	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293001619	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293001620	dimer interface [polypeptide binding]; other site
886293001621	phosphorylation site [posttranslational modification]
886293001622	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293001623	ATP binding site [chemical binding]; other site
886293001624	Mg2+ binding site [ion binding]; other site
886293001625	G-X-G motif; other site
886293001626	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293001627	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293001628	active site
886293001629	phosphorylation site [posttranslational modification]
886293001630	intermolecular recognition site; other site
886293001631	dimerization interface [polypeptide binding]; other site
886293001632	Response regulator receiver domain; Region: Response_reg; pfam00072
886293001633	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293001634	active site
886293001635	phosphorylation site [posttranslational modification]
886293001636	intermolecular recognition site; other site
886293001637	dimerization interface [polypeptide binding]; other site
886293001638	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
886293001639	Response regulator receiver domain; Region: Response_reg; pfam00072
886293001640	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293001641	active site
886293001642	phosphorylation site [posttranslational modification]
886293001643	intermolecular recognition site; other site
886293001644	dimerization interface [polypeptide binding]; other site
886293001645	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
886293001646	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
886293001647	metal binding site [ion binding]; metal-binding site
886293001648	active site
886293001649	I-site; other site
886293001650	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
886293001651	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
886293001652	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
886293001653	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293001654	Walker A/P-loop; other site
886293001655	ATP binding site [chemical binding]; other site
886293001656	Q-loop/lid; other site
886293001657	ABC transporter signature motif; other site
886293001658	Walker B; other site
886293001659	D-loop; other site
886293001660	H-loop/switch region; other site
886293001661	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
886293001662	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
886293001663	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
886293001664	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
886293001665	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
886293001666	ATP binding site [chemical binding]; other site
886293001667	Mg2+ binding site [ion binding]; other site
886293001668	G-X-G motif; other site
886293001669	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
886293001670	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
886293001671	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293001672	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293001673	dimer interface [polypeptide binding]; other site
886293001674	phosphorylation site [posttranslational modification]
886293001675	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293001676	ATP binding site [chemical binding]; other site
886293001677	Mg2+ binding site [ion binding]; other site
886293001678	G-X-G motif; other site
886293001679	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293001680	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293001681	active site
886293001682	phosphorylation site [posttranslational modification]
886293001683	intermolecular recognition site; other site
886293001684	dimerization interface [polypeptide binding]; other site
886293001685	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293001686	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293001687	active site
886293001688	phosphorylation site [posttranslational modification]
886293001689	intermolecular recognition site; other site
886293001690	dimerization interface [polypeptide binding]; other site
886293001691	Response regulator receiver domain; Region: Response_reg; pfam00072
886293001692	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293001693	active site
886293001694	phosphorylation site [posttranslational modification]
886293001695	intermolecular recognition site; other site
886293001696	dimerization interface [polypeptide binding]; other site
886293001697	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
886293001698	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293001699	putative active site [active]
886293001700	heme pocket [chemical binding]; other site
886293001701	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293001702	dimer interface [polypeptide binding]; other site
886293001703	phosphorylation site [posttranslational modification]
886293001704	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293001705	ATP binding site [chemical binding]; other site
886293001706	Mg2+ binding site [ion binding]; other site
886293001707	G-X-G motif; other site
886293001708	Response regulator receiver domain; Region: Response_reg; pfam00072
886293001709	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293001710	active site
886293001711	phosphorylation site [posttranslational modification]
886293001712	intermolecular recognition site; other site
886293001713	dimerization interface [polypeptide binding]; other site
886293001714	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293001715	Chalcone-flavanone isomerase; Region: Chalcone; cl03589
886293001716	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
886293001717	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293001718	active site
886293001719	phosphorylation site [posttranslational modification]
886293001720	intermolecular recognition site; other site
886293001721	dimerization interface [polypeptide binding]; other site
886293001722	CheB methylesterase; Region: CheB_methylest; pfam01339
886293001723	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293001724	S-adenosylmethionine binding site [chemical binding]; other site
886293001725	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
886293001726	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
886293001727	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
886293001728	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
886293001729	dimerization interface [polypeptide binding]; other site
886293001730	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
886293001731	dimer interface [polypeptide binding]; other site
886293001732	putative CheW interface [polypeptide binding]; other site
886293001733	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
886293001734	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
886293001735	putative binding surface; other site
886293001736	active site
886293001737	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
886293001738	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293001739	ATP binding site [chemical binding]; other site
886293001740	Mg2+ binding site [ion binding]; other site
886293001741	G-X-G motif; other site
886293001742	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
886293001743	Response regulator receiver domain; Region: Response_reg; pfam00072
886293001744	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293001745	active site
886293001746	phosphorylation site [posttranslational modification]
886293001747	intermolecular recognition site; other site
886293001748	dimerization interface [polypeptide binding]; other site
886293001749	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
886293001750	anti sigma factor interaction site; other site
886293001751	regulatory phosphorylation site [posttranslational modification]; other site
886293001752	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293001753	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293001754	active site
886293001755	phosphorylation site [posttranslational modification]
886293001756	intermolecular recognition site; other site
886293001757	dimerization interface [polypeptide binding]; other site
886293001758	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
886293001759	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
886293001760	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
886293001761	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
886293001762	putative active site [active]
886293001763	metal binding site [ion binding]; metal-binding site
886293001764	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
886293001765	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
886293001766	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293001767	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293001768	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293001769	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
886293001770	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
886293001771	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293001772	active site
886293001773	phosphorylation site [posttranslational modification]
886293001774	intermolecular recognition site; other site
886293001775	dimerization interface [polypeptide binding]; other site
886293001776	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293001777	Walker A motif; other site
886293001778	ATP binding site [chemical binding]; other site
886293001779	Walker B motif; other site
886293001780	arginine finger; other site
886293001781	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
886293001782	CHASE3 domain; Region: CHASE3; cl05000
886293001783	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293001784	dimer interface [polypeptide binding]; other site
886293001785	phosphorylation site [posttranslational modification]
886293001786	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293001787	ATP binding site [chemical binding]; other site
886293001788	Mg2+ binding site [ion binding]; other site
886293001789	G-X-G motif; other site
886293001790	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
886293001791	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
886293001792	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
886293001793	SnoaL-like domain; Region: SnoaL_3; pfam13474
886293001794	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
886293001795	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
886293001796	TPR motif; other site
886293001797	binding surface
886293001798	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
886293001799	CAAX protease self-immunity; Region: Abi; pfam02517
886293001800	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
886293001801	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293001802	Walker A motif; other site
886293001803	ATP binding site [chemical binding]; other site
886293001804	Walker B motif; other site
886293001805	arginine finger; other site
886293001806	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
886293001807	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
886293001808	TAP-like protein; Region: Abhydrolase_4; pfam08386
886293001809	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
886293001810	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
886293001811	Zn2+ binding site [ion binding]; other site
886293001812	Mg2+ binding site [ion binding]; other site
886293001813	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
886293001814	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
886293001815	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; pfam13366
886293001816	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
886293001817	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
886293001818	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
886293001819	G1 box; other site
886293001820	GTP/Mg2+ binding site [chemical binding]; other site
886293001821	G2 box; other site
886293001822	Switch I region; other site
886293001823	G3 box; other site
886293001824	Switch II region; other site
886293001825	G4 box; other site
886293001826	G5 box; other site
886293001827	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
886293001828	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
886293001829	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
886293001830	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
886293001831	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
886293001832	active site
886293001833	metal binding site [ion binding]; metal-binding site
886293001834	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
886293001835	Glycoprotease family; Region: Peptidase_M22; pfam00814
886293001836	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293001837	Methyltransferase domain; Region: Methyltransf_31; pfam13847
886293001838	S-adenosylmethionine binding site [chemical binding]; other site
886293001839	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
886293001840	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
886293001841	Protein of unknown function (DUF962); Region: DUF962; pfam06127
886293001842	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
886293001843	putative active site [active]
886293001844	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
886293001845	active site
886293001846	NTP binding site [chemical binding]; other site
886293001847	metal binding triad [ion binding]; metal-binding site
886293001848	antibiotic binding site [chemical binding]; other site
886293001849	Uncharacterized conserved protein [Function unknown]; Region: COG2361
886293001850	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293001851	S-adenosylmethionine binding site [chemical binding]; other site
886293001852	Putative esterase; Region: Esterase; pfam00756
886293001853	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
886293001854	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293001855	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
886293001856	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293001857	Walker A/P-loop; other site
886293001858	ATP binding site [chemical binding]; other site
886293001859	Q-loop/lid; other site
886293001860	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
886293001861	ABC transporter signature motif; other site
886293001862	Walker B; other site
886293001863	D-loop; other site
886293001864	H-loop/switch region; other site
886293001865	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
886293001866	dimer interface [polypeptide binding]; other site
886293001867	ADP-ribose binding site [chemical binding]; other site
886293001868	active site
886293001869	nudix motif; other site
886293001870	metal binding site [ion binding]; metal-binding site
886293001871	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293001872	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
886293001873	active site
886293001874	motif I; other site
886293001875	motif II; other site
886293001876	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293001877	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
886293001878	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
886293001879	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
886293001880	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
886293001881	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
886293001882	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
886293001883	manganese transport protein MntH; Reviewed; Region: PRK00701
886293001884	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
886293001885	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
886293001886	Ligand Binding Site [chemical binding]; other site
886293001887	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
886293001888	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293001889	Coenzyme A binding pocket [chemical binding]; other site
886293001890	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
886293001891	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
886293001892	DDE superfamily endonuclease; Region: DDE_5; cl17874
886293001893	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293001894	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293001895	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
886293001896	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
886293001897	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
886293001898	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
886293001899	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
886293001900	cobalamin binding residues [chemical binding]; other site
886293001901	putative BtuC binding residues; other site
886293001902	dimer interface [polypeptide binding]; other site
886293001903	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
886293001904	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
886293001905	5S rRNA interface [nucleotide binding]; other site
886293001906	CTC domain interface [polypeptide binding]; other site
886293001907	L16 interface [polypeptide binding]; other site
886293001908	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
886293001909	putative active site [active]
886293001910	catalytic residue [active]
886293001911	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
886293001912	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
886293001913	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
886293001914	dimer interface [polypeptide binding]; other site
886293001915	ssDNA binding site [nucleotide binding]; other site
886293001916	tetramer (dimer of dimers) interface [polypeptide binding]; other site
886293001917	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
886293001918	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
886293001919	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
886293001920	replicative DNA helicase; Region: DnaB; TIGR00665
886293001921	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
886293001922	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
886293001923	Walker A motif; other site
886293001924	ATP binding site [chemical binding]; other site
886293001925	Walker B motif; other site
886293001926	DNA binding loops [nucleotide binding]
886293001927	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
886293001928	proposed catalytic triad [active]
886293001929	active site nucleophile [active]
886293001930	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
886293001931	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
886293001932	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
886293001933	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
886293001934	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
886293001935	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
886293001936	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
886293001937	active site
886293001938	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
886293001939	domain_subunit interface; other site
886293001940	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
886293001941	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
886293001942	active site
886293001943	FMN binding site [chemical binding]; other site
886293001944	substrate binding site [chemical binding]; other site
886293001945	3Fe-4S cluster binding site [ion binding]; other site
886293001946	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
886293001947	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
886293001948	Walker A/P-loop; other site
886293001949	ATP binding site [chemical binding]; other site
886293001950	Q-loop/lid; other site
886293001951	ABC transporter signature motif; other site
886293001952	Walker B; other site
886293001953	D-loop; other site
886293001954	H-loop/switch region; other site
886293001955	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
886293001956	cobalt transport protein CbiM; Validated; Region: PRK06265
886293001957	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
886293001958	PDGLE domain; Region: PDGLE; pfam13190
886293001959	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293001960	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
886293001961	CAAX protease self-immunity; Region: Abi; cl00558
886293001962	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
886293001963	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293001964	motif II; other site
886293001965	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293001966	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
886293001967	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
886293001968	CARDB; Region: CARDB; pfam07705
886293001969	CARDB; Region: CARDB; pfam07705
886293001970	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
886293001971	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
886293001972	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
886293001973	dimer interface [polypeptide binding]; other site
886293001974	motif 1; other site
886293001975	active site
886293001976	motif 2; other site
886293001977	motif 3; other site
886293001978	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
886293001979	anticodon binding site; other site
886293001980	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
886293001981	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
886293001982	dimer interface [polypeptide binding]; other site
886293001983	motif 1; other site
886293001984	motif 2; other site
886293001985	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
886293001986	active site
886293001987	motif 3; other site
886293001988	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
886293001989	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
886293001990	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
886293001991	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
886293001992	active site
886293001993	catalytic site [active]
886293001994	substrate binding site [chemical binding]; other site
886293001995	ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187
886293001996	ATP-grasp domain; Region: ATP-grasp_4; cl17255
886293001997	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293001998	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293001999	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293002000	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
886293002001	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293002002	active site
886293002003	ATP binding site [chemical binding]; other site
886293002004	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293002005	substrate binding site [chemical binding]; other site
886293002006	activation loop (A-loop); other site
886293002007	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293002008	Tetratricopeptide repeat; Region: TPR_16; pfam13432
886293002009	TPR motif; other site
886293002010	binding surface
886293002011	TPR repeat; Region: TPR_11; pfam13414
886293002012	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293002013	binding surface
886293002014	TPR motif; other site
886293002015	TPR repeat; Region: TPR_11; pfam13414
886293002016	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
886293002017	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
886293002018	Zn2+ binding site [ion binding]; other site
886293002019	Mg2+ binding site [ion binding]; other site
886293002020	NIPSNAP; Region: NIPSNAP; pfam07978
886293002021	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293002022	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293002023	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293002024	DNA binding residues [nucleotide binding]
886293002025	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
886293002026	MG2 domain; Region: A2M_N; pfam01835
886293002027	Alpha-2-macroglobulin family; Region: A2M; pfam00207
886293002028	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293002029	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293002030	active site
886293002031	ATP binding site [chemical binding]; other site
886293002032	substrate binding site [chemical binding]; other site
886293002033	activation loop (A-loop); other site
886293002034	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293002035	TPR motif; other site
886293002036	Tetratricopeptide repeat; Region: TPR_16; pfam13432
886293002037	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
886293002038	TPR motif; other site
886293002039	TPR repeat; Region: TPR_11; pfam13414
886293002040	binding surface
886293002041	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293002042	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
886293002043	DNA binding residues [nucleotide binding]
886293002044	CRISPR-associated protein; Region: TIGR03986
886293002045	GAF domain; Region: GAF; pfam01590
886293002046	GAF domain; Region: GAF_2; pfam13185
886293002047	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
886293002048	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
886293002049	metal binding site [ion binding]; metal-binding site
886293002050	active site
886293002051	I-site; other site
886293002052	Predicted membrane protein [Function unknown]; Region: COG2259
886293002053	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
886293002054	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
886293002055	catalytic site [active]
886293002056	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
886293002057	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
886293002058	substrate binding pocket [chemical binding]; other site
886293002059	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293002060	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
886293002061	SnoaL-like domain; Region: SnoaL_2; pfam12680
886293002062	HAMP domain; Region: HAMP; pfam00672
886293002063	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293002064	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293002065	dimer interface [polypeptide binding]; other site
886293002066	phosphorylation site [posttranslational modification]
886293002067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293002068	ATP binding site [chemical binding]; other site
886293002069	Mg2+ binding site [ion binding]; other site
886293002070	G-X-G motif; other site
886293002071	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
886293002072	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293002073	active site
886293002074	phosphorylation site [posttranslational modification]
886293002075	intermolecular recognition site; other site
886293002076	dimerization interface [polypeptide binding]; other site
886293002077	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
886293002078	DNA binding site [nucleotide binding]
886293002079	PhoD-like phosphatase; Region: PhoD; pfam09423
886293002080	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
886293002081	putative active site [active]
886293002082	putative metal binding site [ion binding]; other site
886293002083	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
886293002084	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
886293002085	catalytic triad [active]
886293002086	conserved cis-peptide bond; other site
886293002087	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293002088	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293002089	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
886293002090	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
886293002091	THF binding site; other site
886293002092	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
886293002093	substrate binding site [chemical binding]; other site
886293002094	THF binding site; other site
886293002095	zinc-binding site [ion binding]; other site
886293002096	ribonucleoside--diphosphate reductase large subunit; Region: PLN02437
886293002097	ATP cone domain; Region: ATP-cone; pfam03477
886293002098	Class I ribonucleotide reductase; Region: RNR_I; cd01679
886293002099	active site
886293002100	dimer interface [polypeptide binding]; other site
886293002101	catalytic residues [active]
886293002102	effector binding site; other site
886293002103	R2 peptide binding site; other site
886293002104	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
886293002105	dimer interface [polypeptide binding]; other site
886293002106	putative radical transfer pathway; other site
886293002107	diiron center [ion binding]; other site
886293002108	tyrosyl radical; other site
886293002109	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293002110	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293002111	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293002112	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293002113	active site
886293002114	ATP binding site [chemical binding]; other site
886293002115	substrate binding site [chemical binding]; other site
886293002116	activation loop (A-loop); other site
886293002117	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293002118	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293002119	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293002120	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
886293002121	active site
886293002122	Domain of unknown function (DUF336); Region: DUF336; cl01249
886293002123	Domain of unknown function (DUF336); Region: DUF336; cl01249
886293002124	Uncharacterized conserved protein [Function unknown]; Region: COG5276
886293002125	LVIVD repeat; Region: LVIVD; pfam08309
886293002126	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
886293002127	GAF domain; Region: GAF; pfam01590
886293002128	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293002129	PAS domain; Region: PAS_9; pfam13426
886293002130	putative active site [active]
886293002131	heme pocket [chemical binding]; other site
886293002132	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
886293002133	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
886293002134	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293002135	putative active site [active]
886293002136	heme pocket [chemical binding]; other site
886293002137	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293002138	dimer interface [polypeptide binding]; other site
886293002139	phosphorylation site [posttranslational modification]
886293002140	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293002141	ATP binding site [chemical binding]; other site
886293002142	Mg2+ binding site [ion binding]; other site
886293002143	G-X-G motif; other site
886293002144	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293002145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293002146	active site
886293002147	phosphorylation site [posttranslational modification]
886293002148	intermolecular recognition site; other site
886293002149	dimerization interface [polypeptide binding]; other site
886293002150	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
886293002151	HSP70 interaction site [polypeptide binding]; other site
886293002152	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
886293002153	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293002154	putative substrate translocation pore; other site
886293002155	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
886293002156	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293002157	Coenzyme A binding pocket [chemical binding]; other site
886293002158	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
886293002159	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
886293002160	active site pocket [active]
886293002161	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293002162	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293002163	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
886293002164	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
886293002165	putative active site [active]
886293002166	putative metal binding site [ion binding]; other site
886293002167	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293002168	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293002169	BNR repeat-like domain; Region: BNR_2; pfam13088
886293002170	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
886293002171	Asp-box motif; other site
886293002172	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
886293002173	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
886293002174	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293002175	D-galactonate transporter; Region: 2A0114; TIGR00893
886293002176	putative substrate translocation pore; other site
886293002177	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293002178	HEAT repeats; Region: HEAT_2; pfam13646
886293002179	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293002180	Cytochrome c; Region: Cytochrom_C; pfam00034
886293002181	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293002182	Sulfatase; Region: Sulfatase; pfam00884
886293002183	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293002184	Sulfatase; Region: Sulfatase; pfam00884
886293002185	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293002186	Sulfatase; Region: Sulfatase; pfam00884
886293002187	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
886293002188	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
886293002189	catalytic residues [active]
886293002190	catalytic nucleophile [active]
886293002191	Recombinase; Region: Recombinase; pfam07508
886293002192	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
886293002193	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
886293002194	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
886293002195	catalytic residues [active]
886293002196	catalytic nucleophile [active]
886293002197	Recombinase; Region: Recombinase; pfam07508
886293002198	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
886293002199	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
886293002200	von Willebrand factor type A domain; Region: VWA_2; pfam13519
886293002201	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293002202	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293002203	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293002204	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293002205	DNA binding residues [nucleotide binding]
886293002206	Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586
886293002207	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
886293002208	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
886293002209	Protein of unknown function (DUF1595); Region: PSD5; pfam07637
886293002210	Protein of unknown function (DUF1592); Region: PSD4; pfam07631
886293002211	Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627
886293002212	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
886293002213	M28 Zn-Peptidases; Region: M28_like_4; cd08015
886293002214	Peptidase family M28; Region: Peptidase_M28; pfam04389
886293002215	metal binding site [ion binding]; metal-binding site
886293002216	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293002217	Sulfatase; Region: Sulfatase; pfam00884
886293002218	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
886293002219	active site
886293002220	NAD binding site [chemical binding]; other site
886293002221	metal binding site [ion binding]; metal-binding site
886293002222	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
886293002223	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
886293002224	active site
886293002225	dimer interface [polypeptide binding]; other site
886293002226	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
886293002227	dimer interface [polypeptide binding]; other site
886293002228	active site
886293002229	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
886293002230	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
886293002231	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293002232	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293002233	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
886293002234	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293002235	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293002236	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
886293002237	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
886293002238	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
886293002239	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
886293002240	calcium/proton exchanger (cax); Region: cax; TIGR00378
886293002241	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
886293002242	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
886293002243	catalytic triad [active]
886293002244	conserved cis-peptide bond; other site
886293002245	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
886293002246	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293002247	HEAT repeats; Region: HEAT_2; pfam13646
886293002248	Cytochrome c; Region: Cytochrom_C; cl11414
886293002249	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293002250	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
886293002251	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293002252	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293002253	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293002254	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
886293002255	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293002256	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
886293002257	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293002258	putative catalytic residue [active]
886293002259	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293002260	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293002261	catalytic residues [active]
886293002262	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293002263	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293002264	transaldolase-like protein; Provisional; Region: PTZ00411
886293002265	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
886293002266	active site
886293002267	dimer interface [polypeptide binding]; other site
886293002268	catalytic residue [active]
886293002269	DDE superfamily endonuclease; Region: DDE_5; cl17874
886293002270	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293002271	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
886293002272	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293002273	AAA ATPase domain; Region: AAA_16; pfam13191
886293002274	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
886293002275	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
886293002276	active site
886293002277	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
886293002278	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
886293002279	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293002280	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
886293002281	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293002282	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
886293002283	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293002284	extended (e) SDRs; Region: SDR_e; cd08946
886293002285	NAD(P) binding site [chemical binding]; other site
886293002286	active site
886293002287	substrate binding site [chemical binding]; other site
886293002288	SurA N-terminal domain; Region: SurA_N; pfam09312
886293002289	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
886293002290	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
886293002291	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
886293002292	Domain of unknown function (DUF202); Region: DUF202; pfam02656
886293002293	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
886293002294	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
886293002295	serine racemase; Region: PLN02970
886293002296	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
886293002297	tetramer interface [polypeptide binding]; other site
886293002298	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293002299	catalytic residue [active]
886293002300	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
886293002301	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
886293002302	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
886293002303	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
886293002304	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
886293002305	motif 1; other site
886293002306	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
886293002307	active site
886293002308	motif 2; other site
886293002309	motif 3; other site
886293002310	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
886293002311	anticodon binding site; other site
886293002312	translation initiation factor IF-3; Region: infC; TIGR00168
886293002313	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
886293002314	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
886293002315	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
886293002316	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
886293002317	23S rRNA binding site [nucleotide binding]; other site
886293002318	L21 binding site [polypeptide binding]; other site
886293002319	L13 binding site [polypeptide binding]; other site
886293002320	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
886293002321	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
886293002322	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
886293002323	dimer interface [polypeptide binding]; other site
886293002324	motif 1; other site
886293002325	active site
886293002326	motif 2; other site
886293002327	motif 3; other site
886293002328	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
886293002329	Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072
886293002330	B3/4 domain; Region: B3_4; pfam03483
886293002331	tRNA synthetase B5 domain; Region: B5; smart00874
886293002332	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
886293002333	motif 1; other site
886293002334	dimer interface [polypeptide binding]; other site
886293002335	active site
886293002336	motif 2; other site
886293002337	motif 3; other site
886293002338	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
886293002339	SEC-C motif; Region: SEC-C; pfam02810
886293002340	Small integral membrane protein [Function unknown]; Region: COG5487; cl17674
886293002341	CsbD-like; Region: CsbD; cl17424
886293002342	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
886293002343	G3 box; other site
886293002344	Switch II region; other site
886293002345	G4 box; other site
886293002346	limonoid glucosyltransferase; Region: PLN02555
886293002347	FOG: CBS domain [General function prediction only]; Region: COG0517
886293002348	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
886293002349	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
886293002350	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293002351	active site
886293002352	phosphorylation site [posttranslational modification]
886293002353	intermolecular recognition site; other site
886293002354	dimerization interface [polypeptide binding]; other site
886293002355	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293002356	Walker A motif; other site
886293002357	ATP binding site [chemical binding]; other site
886293002358	Walker B motif; other site
886293002359	arginine finger; other site
886293002360	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
886293002361	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
886293002362	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293002363	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293002364	dimer interface [polypeptide binding]; other site
886293002365	phosphorylation site [posttranslational modification]
886293002366	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293002367	ATP binding site [chemical binding]; other site
886293002368	Mg2+ binding site [ion binding]; other site
886293002369	G-X-G motif; other site
886293002370	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
886293002371	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293002372	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293002373	threonine dehydratase; Reviewed; Region: PRK09224
886293002374	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
886293002375	tetramer interface [polypeptide binding]; other site
886293002376	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293002377	catalytic residue [active]
886293002378	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
886293002379	putative Ile/Val binding site [chemical binding]; other site
886293002380	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
886293002381	putative Ile/Val binding site [chemical binding]; other site
886293002382	Cupin-like domain; Region: Cupin_8; pfam13621
886293002383	MULE transposase domain; Region: MULE; pfam10551
886293002384	Methyltransferase domain; Region: Methyltransf_23; pfam13489
886293002385	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293002386	S-adenosylmethionine binding site [chemical binding]; other site
886293002387	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293002388	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293002389	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
886293002390	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293002391	binding surface
886293002392	TPR motif; other site
886293002393	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
886293002394	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
886293002395	active site
886293002396	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
886293002397	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
886293002398	Immunoglobulin I-set domain; Region: I-set; pfam07679
886293002399	Immunoglobulin like; Region: IG_like; smart00410
886293002400	Putative phosphatase (DUF442); Region: DUF442; cl17385
886293002401	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
886293002402	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
886293002403	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293002404	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
886293002405	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293002406	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
886293002407	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
886293002408	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
886293002409	active site
886293002410	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
886293002411	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
886293002412	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
886293002413	Dicarboxylate transport; Region: DctA-YdbH; cl14674
886293002414	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
886293002415	Phage protein; Region: DUF3647; cl10335
886293002416	HEAT repeats; Region: HEAT_2; pfam13646
886293002417	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293002418	D-galactonate transporter; Region: 2A0114; TIGR00893
886293002419	putative substrate translocation pore; other site
886293002420	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
886293002421	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
886293002422	Planctomycetes uncharacterized domain TIGR03009; Region: plancto_dom_2
886293002423	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
886293002424	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293002425	active site
886293002426	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
886293002427	oligomerisation interface [polypeptide binding]; other site
886293002428	mobile loop; other site
886293002429	roof hairpin; other site
886293002430	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
886293002431	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
886293002432	ring oligomerisation interface [polypeptide binding]; other site
886293002433	ATP/Mg binding site [chemical binding]; other site
886293002434	stacking interactions; other site
886293002435	hinge regions; other site
886293002436	Protein of unknown function (DUF502); Region: DUF502; cl01107
886293002437	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
886293002438	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293002439	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
886293002440	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
886293002441	active site
886293002442	Riboflavin kinase; Region: Flavokinase; pfam01687
886293002443	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293002444	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293002445	active site
886293002446	ATP binding site [chemical binding]; other site
886293002447	substrate binding site [chemical binding]; other site
886293002448	activation loop (A-loop); other site
886293002449	ECF sigma factor; Region: Sigma70_ECF; pfam07638
886293002450	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
886293002451	RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989
886293002452	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293002453	FecR protein; Region: FecR; pfam04773
886293002454	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
886293002455	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293002456	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
886293002457	proposed catalytic triad [active]
886293002458	active site nucleophile [active]
886293002459	Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751
886293002460	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293002461	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
886293002462	Walker A/P-loop; other site
886293002463	ATP binding site [chemical binding]; other site
886293002464	Q-loop/lid; other site
886293002465	ABC transporter signature motif; other site
886293002466	Walker B; other site
886293002467	D-loop; other site
886293002468	H-loop/switch region; other site
886293002469	TOBE domain; Region: TOBE; pfam03459
886293002470	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
886293002471	putative PBP binding loops; other site
886293002472	ABC-ATPase subunit interface; other site
886293002473	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
886293002474	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
886293002475	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
886293002476	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
886293002477	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
886293002478	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
886293002479	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
886293002480	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
886293002481	dimer interface [polypeptide binding]; other site
886293002482	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
886293002483	active site
886293002484	Fe binding site [ion binding]; other site
886293002485	ribulokinase; Provisional; Region: PRK04123
886293002486	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
886293002487	nucleotide binding site [chemical binding]; other site
886293002488	polyol permease family; Region: 2A0118; TIGR00897
886293002489	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293002490	putative substrate translocation pore; other site
886293002491	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
886293002492	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
886293002493	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293002494	active site
886293002495	motif I; other site
886293002496	motif II; other site
886293002497	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293002498	Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175
886293002499	active site
886293002500	metal binding site [ion binding]; metal-binding site
886293002501	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
886293002502	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
886293002503	DNA binding residues [nucleotide binding]
886293002504	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
886293002505	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
886293002506	pseudouridine synthase; Region: TIGR00093
886293002507	active site
886293002508	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
886293002509	putative active site [active]
886293002510	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
886293002511	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
886293002512	ATP binding site [chemical binding]; other site
886293002513	putative Mg++ binding site [ion binding]; other site
886293002514	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293002515	nucleotide binding region [chemical binding]; other site
886293002516	ATP-binding site [chemical binding]; other site
886293002517	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
886293002518	Protein of unknown function (DUF790); Region: DUF790; pfam05626
886293002519	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
886293002520	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
886293002521	active site
886293002522	intersubunit interface [polypeptide binding]; other site
886293002523	catalytic residue [active]
886293002524	cobalamin synthase; Reviewed; Region: cobS; PRK00235
886293002525	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
886293002526	homotrimer interface [polypeptide binding]; other site
886293002527	Walker A motif; other site
886293002528	GTP binding site [chemical binding]; other site
886293002529	Walker B motif; other site
886293002530	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293002531	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293002532	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293002533	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
886293002534	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
886293002535	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
886293002536	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293002537	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
886293002538	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
886293002539	protein-splicing catalytic site; other site
886293002540	thioester formation/cholesterol transfer; other site
886293002541	Pretoxin HINT domain; Region: PT-HINT; pfam07591
886293002542	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
886293002543	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293002544	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293002545	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293002546	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293002547	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
886293002548	Ligand binding site; other site
886293002549	Putative Catalytic site; other site
886293002550	DXD motif; other site
886293002551	PAS domain; Region: PAS; smart00091
886293002552	PAS fold; Region: PAS; pfam00989
886293002553	PAS domain S-box; Region: sensory_box; TIGR00229
886293002554	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293002555	putative active site [active]
886293002556	heme pocket [chemical binding]; other site
886293002557	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
886293002558	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293002559	putative active site [active]
886293002560	heme pocket [chemical binding]; other site
886293002561	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293002562	dimer interface [polypeptide binding]; other site
886293002563	phosphorylation site [posttranslational modification]
886293002564	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293002565	ATP binding site [chemical binding]; other site
886293002566	Mg2+ binding site [ion binding]; other site
886293002567	G-X-G motif; other site
886293002568	Response regulator receiver domain; Region: Response_reg; pfam00072
886293002569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293002570	active site
886293002571	phosphorylation site [posttranslational modification]
886293002572	intermolecular recognition site; other site
886293002573	dimerization interface [polypeptide binding]; other site
886293002574	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293002575	HEAT repeats; Region: HEAT_2; pfam13646
886293002576	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
886293002577	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
886293002578	protein binding surface [polypeptide binding]; other site
886293002579	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293002580	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
886293002581	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293002582	putative substrate translocation pore; other site
886293002583	malate dehydrogenase; Provisional; Region: PRK05442
886293002584	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
886293002585	NAD(P) binding site [chemical binding]; other site
886293002586	dimer interface [polypeptide binding]; other site
886293002587	malate binding site [chemical binding]; other site
886293002588	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293002589	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293002590	catalytic residues [active]
886293002591	Family description; Region: VCBS; pfam13517
886293002592	Family description; Region: VCBS; pfam13517
886293002593	Family description; Region: VCBS; pfam13517
886293002594	Family description; Region: VCBS; pfam13517
886293002595	Family description; Region: VCBS; pfam13517
886293002596	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
886293002597	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
886293002598	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
886293002599	Predicted permease [General function prediction only]; Region: COG3329
886293002600	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
886293002601	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
886293002602	active site
886293002603	DNA binding site [nucleotide binding]
886293002604	Int/Topo IB signature motif; other site
886293002605	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
886293002606	active site
886293002607	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293002608	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
886293002609	NAD(P) binding site [chemical binding]; other site
886293002610	active site
886293002611	CopC domain; Region: CopC; cl01012
886293002612	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
886293002613	AAA domain; Region: AAA_31; pfam13614
886293002614	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
886293002615	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293002616	Walker A motif; other site
886293002617	ATP binding site [chemical binding]; other site
886293002618	Walker B motif; other site
886293002619	arginine finger; other site
886293002620	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
886293002621	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
886293002622	ATP-dependent helicase; Provisional; Region: PRK13767
886293002623	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
886293002624	ATP binding site [chemical binding]; other site
886293002625	putative Mg++ binding site [ion binding]; other site
886293002626	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293002627	nucleotide binding region [chemical binding]; other site
886293002628	ATP-binding site [chemical binding]; other site
886293002629	DEAD/H associated; Region: DEAD_assoc; pfam08494
886293002630	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
886293002631	active site
886293002632	metal binding site [ion binding]; metal-binding site
886293002633	Domain of unknown function (DUF362); Region: DUF362; pfam04015
886293002634	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293002635	HEAT repeats; Region: HEAT_2; pfam13646
886293002636	L-type amino acid transporter; Region: 2A0308; TIGR00911
886293002637	HEAT repeats; Region: HEAT_2; pfam13646
886293002638	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
886293002639	ribonuclease R; Region: RNase_R; TIGR02063
886293002640	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
886293002641	RNB domain; Region: RNB; pfam00773
886293002642	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
886293002643	RNA binding site [nucleotide binding]; other site
886293002644	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
886293002645	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
886293002646	generic binding surface II; other site
886293002647	generic binding surface I; other site
886293002648	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
886293002649	Zn2+ binding site [ion binding]; other site
886293002650	Mg2+ binding site [ion binding]; other site
886293002651	CARDB; Region: CARDB; pfam07705
886293002652	prolyl-tRNA synthetase; Provisional; Region: PRK09194
886293002653	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
886293002654	dimer interface [polypeptide binding]; other site
886293002655	motif 1; other site
886293002656	active site
886293002657	motif 2; other site
886293002658	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
886293002659	putative deacylase active site [active]
886293002660	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
886293002661	active site
886293002662	motif 3; other site
886293002663	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
886293002664	anticodon binding site; other site
886293002665	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
886293002666	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
886293002667	FeS/SAM binding site; other site
886293002668	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293002669	Methyltransferase domain; Region: Methyltransf_23; pfam13489
886293002670	Uncharacterized conserved protein [Function unknown]; Region: COG3379
886293002671	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
886293002672	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
886293002673	metal binding site 2 [ion binding]; metal-binding site
886293002674	putative DNA binding helix; other site
886293002675	metal binding site 1 [ion binding]; metal-binding site
886293002676	dimer interface [polypeptide binding]; other site
886293002677	structural Zn2+ binding site [ion binding]; other site
886293002678	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
886293002679	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
886293002680	mce related protein; Region: MCE; pfam02470
886293002681	HEAT repeats; Region: HEAT_2; pfam13646
886293002682	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
886293002683	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
886293002684	tetramer interface [polypeptide binding]; other site
886293002685	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293002686	catalytic residue [active]
886293002687	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
886293002688	histidinol dehydrogenase; Region: hisD; TIGR00069
886293002689	NAD binding site [chemical binding]; other site
886293002690	dimerization interface [polypeptide binding]; other site
886293002691	product binding site; other site
886293002692	substrate binding site [chemical binding]; other site
886293002693	zinc binding site [ion binding]; other site
886293002694	catalytic residues [active]
886293002695	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
886293002696	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293002697	Coenzyme A binding pocket [chemical binding]; other site
886293002698	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
886293002699	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
886293002700	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293002701	homodimer interface [polypeptide binding]; other site
886293002702	catalytic residue [active]
886293002703	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293002704	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
886293002705	putative active site pocket [active]
886293002706	4-fold oligomerization interface [polypeptide binding]; other site
886293002707	metal binding residues [ion binding]; metal-binding site
886293002708	3-fold/trimer interface [polypeptide binding]; other site
886293002709	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
886293002710	amino acid transporter; Region: 2A0306; TIGR00909
886293002711	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
886293002712	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293002713	Protein of unknown function (DUF1587); Region: PSD3; pfam07626
886293002714	Protein of unknown function (DUF1595); Region: PSD5; pfam07637
886293002715	Protein of unknown function (DUF1592); Region: PSD4; pfam07631
886293002716	Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627
886293002717	Protein of unknown function (DUF1585); Region: PSD2; pfam07624
886293002718	Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586
886293002719	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
886293002720	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
886293002721	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
886293002722	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
886293002723	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
886293002724	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
886293002725	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
886293002726	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
886293002727	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
886293002728	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293002729	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293002730	active site
886293002731	ATP binding site [chemical binding]; other site
886293002732	substrate binding site [chemical binding]; other site
886293002733	activation loop (A-loop); other site
886293002734	Predicted ATPase [General function prediction only]; Region: COG3899
886293002735	AAA ATPase domain; Region: AAA_16; pfam13191
886293002736	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293002737	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293002738	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
886293002739	active site
886293002740	HIGH motif; other site
886293002741	nucleotide binding site [chemical binding]; other site
886293002742	active site
886293002743	KMSKS motif; other site
886293002744	peptide chain release factor 2; Validated; Region: prfB; PRK00578
886293002745	This domain is found in peptide chain release factors; Region: PCRF; smart00937
886293002746	RF-1 domain; Region: RF-1; pfam00472
886293002747	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
886293002748	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
886293002749	dimer interface [polypeptide binding]; other site
886293002750	active site
886293002751	glycine-pyridoxal phosphate binding site [chemical binding]; other site
886293002752	folate binding site [chemical binding]; other site
886293002753	Colicin V production protein; Region: Colicin_V; pfam02674
886293002754	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
886293002755	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
886293002756	Acyltransferase family; Region: Acyl_transf_3; pfam01757
886293002757	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
886293002758	Methane oxygenase PmoA; Region: PmoA; pfam14100
886293002759	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
886293002760	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
886293002761	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
886293002762	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
886293002763	SPFH domain / Band 7 family; Region: Band_7; pfam01145
886293002764	SPFH domain / Band 7 family; Region: Band_7; pfam01145
886293002765	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
886293002766	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
886293002767	homodimer interface [polypeptide binding]; other site
886293002768	putative substrate binding pocket [chemical binding]; other site
886293002769	diiron center [ion binding]; other site
886293002770	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
886293002771	UreD urease accessory protein; Region: UreD; pfam01774
886293002772	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
886293002773	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
886293002774	UreF; Region: UreF; pfam01730
886293002775	urease accessory protein UreE; Provisional; Region: ureE; PRK14711
886293002776	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
886293002777	dimer interface [polypeptide binding]; other site
886293002778	catalytic residues [active]
886293002779	urease subunit alpha; Reviewed; Region: ureC; PRK13207
886293002780	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
886293002781	subunit interactions [polypeptide binding]; other site
886293002782	active site
886293002783	flap region; other site
886293002784	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
886293002785	alpha-beta subunit interface [polypeptide binding]; other site
886293002786	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
886293002787	alpha-gamma subunit interface [polypeptide binding]; other site
886293002788	beta-gamma subunit interface [polypeptide binding]; other site
886293002789	Urea transporter; Region: UT; pfam03253
886293002790	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
886293002791	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
886293002792	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293002793	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
886293002794	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
886293002795	catalytic site [active]
886293002796	putative active site [active]
886293002797	putative substrate binding site [chemical binding]; other site
886293002798	HRDC domain; Region: HRDC; pfam00570
886293002799	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
886293002800	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
886293002801	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
886293002802	catalytic site [active]
886293002803	TAP-like protein; Region: Abhydrolase_4; pfam08386
886293002804	TPR repeat; Region: TPR_11; pfam13414
886293002805	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293002806	binding surface
886293002807	TPR motif; other site
886293002808	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
886293002809	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
886293002810	metal binding site [ion binding]; metal-binding site
886293002811	putative dimer interface [polypeptide binding]; other site
886293002812	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme D-Threonine Aldolase; Region: PLPDE_III_D-TA; cd06821
886293002813	dimer interface [polypeptide binding]; other site
886293002814	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
886293002815	active site
886293002816	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
886293002817	substrate binding site [chemical binding]; other site
886293002818	catalytic residue [active]
886293002819	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
886293002820	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293002821	non-specific DNA binding site [nucleotide binding]; other site
886293002822	salt bridge; other site
886293002823	sequence-specific DNA binding site [nucleotide binding]; other site
886293002824	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
886293002825	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293002826	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
886293002827	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
886293002828	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
886293002829	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
886293002830	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293002831	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293002832	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293002833	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293002834	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
886293002835	active site
886293002836	catalytic site [active]
886293002837	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293002838	S-adenosylmethionine binding site [chemical binding]; other site
886293002839	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
886293002840	nucleotide binding site [chemical binding]; other site
886293002841	substrate binding site [chemical binding]; other site
886293002842	Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668
886293002843	ATP-grasp domain; Region: ATP-grasp_4; cl17255
886293002844	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
886293002845	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
886293002846	phosphate binding site [ion binding]; other site
886293002847	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293002848	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293002849	active site
886293002850	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
886293002851	Stf0 sulphotransferase; Region: Sulphotransf; cl01835
886293002852	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
886293002853	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293002854	active site
886293002855	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
886293002856	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
886293002857	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
886293002858	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
886293002859	trimerization site [polypeptide binding]; other site
886293002860	active site
886293002861	DDE superfamily endonuclease; Region: DDE_5; cl17874
886293002862	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
886293002863	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
886293002864	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874
886293002865	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
886293002866	ATP-grasp domain; Region: ATP-grasp_4; cl17255
886293002867	Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria.  It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545
886293002868	N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264
886293002869	trimer interface I [polypeptide binding]; other site
886293002870	putative substrate binding pocket [chemical binding]; other site
886293002871	trimer interface II [polypeptide binding]; other site
886293002872	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
886293002873	domain_subunit interface; other site
886293002874	HflK protein; Region: hflK; TIGR01933
886293002875	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
886293002876	formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114
886293002877	Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913
886293002878	FTR, proximal lobe; Region: FTR_C; pfam02741
886293002879	formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121
886293002880	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293002881	active site
886293002882	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
886293002883	formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129
886293002884	molybdopterin cofactor binding site; other site
886293002885	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
886293002886	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293002887	NAD(P) binding site [chemical binding]; other site
886293002888	active site
886293002889	dihydropteroate synthase-related protein; Region: TIGR00284
886293002890	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
886293002891	substrate binding pocket [chemical binding]; other site
886293002892	inhibitor binding site; inhibition site
886293002893	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
886293002894	Protein of unknown function (DUF447); Region: DUF447; pfam04289
886293002895	Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907
886293002896	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
886293002897	Domain of unknown function (DUF4380); Region: DUF4380; pfam14315
886293002898	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
886293002899	Putative glucoamylase; Region: Glycoamylase; pfam10091
886293002900	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
886293002901	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
886293002902	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
886293002903	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
886293002904	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
886293002905	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293002906	Walker A/P-loop; other site
886293002907	ATP binding site [chemical binding]; other site
886293002908	Q-loop/lid; other site
886293002909	ABC transporter signature motif; other site
886293002910	Walker B; other site
886293002911	D-loop; other site
886293002912	H-loop/switch region; other site
886293002913	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293002914	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
886293002915	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293002916	active site
886293002917	ATP binding site [chemical binding]; other site
886293002918	substrate binding site [chemical binding]; other site
886293002919	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293002920	TPR motif; other site
886293002921	binding surface
886293002922	TPR repeat; Region: TPR_11; pfam13414
886293002923	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293002924	binding surface
886293002925	TPR motif; other site
886293002926	Uncharacterized conserved protein [Function unknown]; Region: COG0393
886293002927	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
886293002928	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
886293002929	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
886293002930	active site
886293002931	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
886293002932	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
886293002933	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
886293002934	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
886293002935	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
886293002936	FMN binding site [chemical binding]; other site
886293002937	active site
886293002938	substrate binding site [chemical binding]; other site
886293002939	catalytic residue [active]
886293002940	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
886293002941	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
886293002942	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
886293002943	catalytic residue [active]
886293002944	Fe-S metabolism associated domain; Region: SufE; cl00951
886293002945	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
886293002946	Predicted amidohydrolase [General function prediction only]; Region: COG0388
886293002947	putative active site [active]
886293002948	catalytic triad [active]
886293002949	putative dimer interface [polypeptide binding]; other site
886293002950	Protein of unknown function (DUF983); Region: DUF983; cl02211
886293002951	Cupin domain; Region: Cupin_2; pfam07883
886293002952	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
886293002953	GAF domain; Region: GAF; cl17456
886293002954	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293002955	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
886293002956	Walker A motif; other site
886293002957	ATP binding site [chemical binding]; other site
886293002958	Walker B motif; other site
886293002959	arginine finger; other site
886293002960	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293002961	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
886293002962	putative dimerization interface [polypeptide binding]; other site
886293002963	putative ligand binding site [chemical binding]; other site
886293002964	Transcriptional regulators [Transcription]; Region: PurR; COG1609
886293002965	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293002966	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
886293002967	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293002968	Repair protein; Region: Repair_PSII; pfam04536
886293002969	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
886293002970	30S subunit binding site; other site
886293002971	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
886293002972	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
886293002973	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293002974	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293002975	structural tetrad; other site
886293002976	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
886293002977	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293002978	active site
886293002979	phosphorylation site [posttranslational modification]
886293002980	intermolecular recognition site; other site
886293002981	dimerization interface [polypeptide binding]; other site
886293002982	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293002983	Walker A motif; other site
886293002984	ATP binding site [chemical binding]; other site
886293002985	Walker B motif; other site
886293002986	arginine finger; other site
886293002987	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
886293002988	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293002989	dimer interface [polypeptide binding]; other site
886293002990	phosphorylation site [posttranslational modification]
886293002991	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293002992	ATP binding site [chemical binding]; other site
886293002993	G-X-G motif; other site
886293002994	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
886293002995	30S subunit binding site; other site
886293002996	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
886293002997	active site clefts [active]
886293002998	zinc binding site [ion binding]; other site
886293002999	dimer interface [polypeptide binding]; other site
886293003000	Urea transporter; Region: UT; pfam03253
886293003001	Urea transporter; Region: UT; pfam03253
886293003002	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
886293003003	alpha-gamma subunit interface [polypeptide binding]; other site
886293003004	beta-gamma subunit interface [polypeptide binding]; other site
886293003005	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
886293003006	gamma-beta subunit interface [polypeptide binding]; other site
886293003007	alpha-beta subunit interface [polypeptide binding]; other site
886293003008	urease subunit alpha; Reviewed; Region: ureC; PRK13207
886293003009	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
886293003010	subunit interactions [polypeptide binding]; other site
886293003011	active site
886293003012	flap region; other site
886293003013	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
886293003014	UreF; Region: UreF; pfam01730
886293003015	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
886293003016	G1 box; other site
886293003017	GTP/Mg2+ binding site [chemical binding]; other site
886293003018	G2 box; other site
886293003019	Switch I region; other site
886293003020	G3 box; other site
886293003021	Switch II region; other site
886293003022	G4 box; other site
886293003023	G5 box; other site
886293003024	UreD urease accessory protein; Region: UreD; pfam01774
886293003025	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
886293003026	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293003027	Tetratricopeptide repeat; Region: TPR_10; pfam13374
886293003028	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293003029	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293003030	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293003031	binding surface
886293003032	TPR motif; other site
886293003033	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293003034	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293003035	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293003036	TPR motif; other site
886293003037	binding surface
886293003038	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293003039	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
886293003040	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
886293003041	SnoaL-like domain; Region: SnoaL_3; pfam13474
886293003042	Tetratricopeptide repeat; Region: TPR_16; pfam13432
886293003043	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293003044	TPR motif; other site
886293003045	binding surface
886293003046	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
886293003047	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293003048	NAD(P) binding site [chemical binding]; other site
886293003049	active site
886293003050	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293003051	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293003052	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293003053	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293003054	TPR motif; other site
886293003055	TPR repeat; Region: TPR_11; pfam13414
886293003056	binding surface
886293003057	purine nucleoside phosphorylase; Provisional; Region: PRK08202
886293003058	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
886293003059	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
886293003060	active site
886293003061	HIGH motif; other site
886293003062	nucleotide binding site [chemical binding]; other site
886293003063	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
886293003064	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
886293003065	active site
886293003066	KMSKS motif; other site
886293003067	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
886293003068	tRNA binding surface [nucleotide binding]; other site
886293003069	anticodon binding site; other site
886293003070	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
886293003071	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
886293003072	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
886293003073	Mg++ binding site [ion binding]; other site
886293003074	putative catalytic motif [active]
886293003075	substrate binding site [chemical binding]; other site
886293003076	O-Antigen ligase; Region: Wzy_C; pfam04932
886293003077	Haem-binding domain; Region: Haem_bd; pfam14376
886293003078	Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712
886293003079	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
886293003080	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
886293003081	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
886293003082	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
886293003083	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
886293003084	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
886293003085	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
886293003086	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293003087	Walker A motif; other site
886293003088	ATP binding site [chemical binding]; other site
886293003089	Walker B motif; other site
886293003090	arginine finger; other site
886293003091	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
886293003092	hypothetical protein; Validated; Region: PRK00153
886293003093	recombination protein RecR; Reviewed; Region: recR; PRK00076
886293003094	RecR protein; Region: RecR; pfam02132
886293003095	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
886293003096	putative active site [active]
886293003097	putative metal-binding site [ion binding]; other site
886293003098	tetramer interface [polypeptide binding]; other site
886293003099	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
886293003100	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
886293003101	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
886293003102	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
886293003103	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293003104	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
886293003105	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293003106	active site
886293003107	phosphorylation site [posttranslational modification]
886293003108	intermolecular recognition site; other site
886293003109	dimerization interface [polypeptide binding]; other site
886293003110	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293003111	Walker A motif; other site
886293003112	ATP binding site [chemical binding]; other site
886293003113	Walker B motif; other site
886293003114	arginine finger; other site
886293003115	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
886293003116	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
886293003117	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
886293003118	active site
886293003119	DNA binding site [nucleotide binding]
886293003120	Int/Topo IB signature motif; other site
886293003121	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
886293003122	active site 2 [active]
886293003123	active site 1 [active]
886293003124	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293003125	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293003126	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293003127	DNA binding residues [nucleotide binding]
886293003128	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293003129	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
886293003130	phosphopeptide binding site; other site
886293003131	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
886293003132	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
886293003133	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293003134	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293003135	ATP binding site [chemical binding]; other site
886293003136	Mg2+ binding site [ion binding]; other site
886293003137	G-X-G motif; other site
886293003138	mce related protein; Region: MCE; pfam02470
886293003139	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
886293003140	ligand binding site [chemical binding]; other site
886293003141	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
886293003142	Permease; Region: Permease; pfam02405
886293003143	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
886293003144	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
886293003145	active site
886293003146	catalytic residues [active]
886293003147	metal binding site [ion binding]; metal-binding site
886293003148	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
886293003149	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
886293003150	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
886293003151	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
886293003152	Beta-Casp domain; Region: Beta-Casp; smart01027
886293003153	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
886293003154	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
886293003155	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
886293003156	substrate binding site [chemical binding]; other site
886293003157	active site
886293003158	catalytic residues [active]
886293003159	heterodimer interface [polypeptide binding]; other site
886293003160	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
886293003161	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
886293003162	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293003163	catalytic residue [active]
886293003164	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293003165	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
886293003166	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
886293003167	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
886293003168	active site
886293003169	dimer interface [polypeptide binding]; other site
886293003170	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
886293003171	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
886293003172	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293003173	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293003174	binding surface
886293003175	TPR motif; other site
886293003176	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293003177	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293003178	binding surface
886293003179	TPR motif; other site
886293003180	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
886293003181	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
886293003182	catalytic loop [active]
886293003183	iron binding site [ion binding]; other site
886293003184	Bacterial PH domain; Region: DUF304; pfam03703
886293003185	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293003186	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
886293003187	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
886293003188	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293003189	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293003190	active site
886293003191	ATP binding site [chemical binding]; other site
886293003192	substrate binding site [chemical binding]; other site
886293003193	activation loop (A-loop); other site
886293003194	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
886293003195	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
886293003196	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
886293003197	active site
886293003198	PHP Thumb interface [polypeptide binding]; other site
886293003199	metal binding site [ion binding]; metal-binding site
886293003200	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
886293003201	generic binding surface II; other site
886293003202	generic binding surface I; other site
886293003203	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293003204	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293003205	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
886293003206	NAD(P) binding site [chemical binding]; other site
886293003207	active site
886293003208	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
886293003209	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
886293003210	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
886293003211	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
886293003212	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
886293003213	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
886293003214	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
886293003215	dimer interface [polypeptide binding]; other site
886293003216	active site
886293003217	acyl carrier protein; Provisional; Region: acpP; PRK00982
886293003218	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
886293003219	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
886293003220	NAD(P) binding site [chemical binding]; other site
886293003221	homotetramer interface [polypeptide binding]; other site
886293003222	homodimer interface [polypeptide binding]; other site
886293003223	active site
886293003224	[acyl-carrier protein] S-malonyltransferase; Region: PLN02752
886293003225	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
886293003226	putative phosphate acyltransferase; Provisional; Region: PRK05331
886293003227	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
886293003228	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
886293003229	GTPase RsgA; Reviewed; Region: PRK00098
886293003230	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
886293003231	RNA binding site [nucleotide binding]; other site
886293003232	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
886293003233	GTPase/Zn-binding domain interface [polypeptide binding]; other site
886293003234	GTP/Mg2+ binding site [chemical binding]; other site
886293003235	G4 box; other site
886293003236	G5 box; other site
886293003237	G1 box; other site
886293003238	Switch I region; other site
886293003239	G2 box; other site
886293003240	G3 box; other site
886293003241	Switch II region; other site
886293003242	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293003243	PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; pfam10142
886293003244	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
886293003245	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
886293003246	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
886293003247	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
886293003248	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293003249	HEAT repeats; Region: HEAT_2; pfam13646
886293003250	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293003251	Cytochrome c; Region: Cytochrom_C; pfam00034
886293003252	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
886293003253	metal binding site [ion binding]; metal-binding site
886293003254	amino acid transporter; Region: 2A0306; TIGR00909
886293003255	Transcriptional regulator; Region: Rrf2; cl17282
886293003256	Rrf2 family protein; Region: rrf2_super; TIGR00738
886293003257	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
886293003258	TIGR00159 family protein; Region: TIGR00159
886293003259	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
886293003260	Penicillinase repressor; Region: Pencillinase_R; cl17580
886293003261	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
886293003262	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
886293003263	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
886293003264	Zn binding site [ion binding]; other site
886293003265	Surface antigen; Region: Bac_surface_Ag; pfam01103
886293003266	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
886293003267	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
886293003268	dimer interface [polypeptide binding]; other site
886293003269	active site
886293003270	aspartate aminotransferase; Provisional; Region: PRK05764
886293003271	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
886293003272	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293003273	homodimer interface [polypeptide binding]; other site
886293003274	catalytic residue [active]
886293003275	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293003276	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293003277	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293003278	DNA binding residues [nucleotide binding]
886293003279	Response regulator receiver domain; Region: Response_reg; pfam00072
886293003280	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293003281	active site
886293003282	phosphorylation site [posttranslational modification]
886293003283	intermolecular recognition site; other site
886293003284	dimerization interface [polypeptide binding]; other site
886293003285	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
886293003286	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
886293003287	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
886293003288	putative RNA binding site [nucleotide binding]; other site
886293003289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293003290	S-adenosylmethionine binding site [chemical binding]; other site
886293003291	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
886293003292	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
886293003293	Penicillinase repressor; Region: Pencillinase_R; pfam03965
886293003294	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293003295	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
886293003296	Predicted membrane protein [Function unknown]; Region: COG4485
886293003297	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293003298	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293003299	active site
886293003300	ATP binding site [chemical binding]; other site
886293003301	substrate binding site [chemical binding]; other site
886293003302	activation loop (A-loop); other site
886293003303	tartrate dehydrogenase; Region: TTC; TIGR02089
886293003304	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
886293003305	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
886293003306	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
886293003307	active site
886293003308	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293003309	Ferredoxin [Energy production and conversion]; Region: COG1146
886293003310	4Fe-4S binding domain; Region: Fer4; cl02805
886293003311	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
886293003312	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
886293003313	substrate binding site [chemical binding]; other site
886293003314	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
886293003315	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
886293003316	ATP binding site [chemical binding]; other site
886293003317	putative Mg++ binding site [ion binding]; other site
886293003318	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293003319	nucleotide binding region [chemical binding]; other site
886293003320	ATP-binding site [chemical binding]; other site
886293003321	DEAD/H associated; Region: DEAD_assoc; pfam08494
886293003322	MarR family; Region: MarR_2; pfam12802
886293003323	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293003324	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293003325	active site
886293003326	ATP binding site [chemical binding]; other site
886293003327	substrate binding site [chemical binding]; other site
886293003328	activation loop (A-loop); other site
886293003329	Protein phosphatase 2C; Region: PP2C; pfam00481
886293003330	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
886293003331	active site
886293003332	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
886293003333	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
886293003334	active site
886293003335	putative homodimer interface [polypeptide binding]; other site
886293003336	SAM binding site [chemical binding]; other site
886293003337	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
886293003338	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293003339	S-adenosylmethionine binding site [chemical binding]; other site
886293003340	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
886293003341	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
886293003342	putative ligand binding pocket/active site [active]
886293003343	putative metal binding site [ion binding]; other site
886293003344	Planctomycetes uncharacterized domain TIGR03009; Region: plancto_dom_2
886293003345	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
886293003346	active site
886293003347	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
886293003348	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
886293003349	active site
886293003350	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
886293003351	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
886293003352	hypothetical protein; Provisional; Region: PRK13665
886293003353	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
886293003354	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
886293003355	catalytic residues [active]
886293003356	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
886293003357	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
886293003358	NAD(P) binding site [chemical binding]; other site
886293003359	catalytic residues [active]
886293003360	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
886293003361	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
886293003362	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
886293003363	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
886293003364	dimer interface [polypeptide binding]; other site
886293003365	PYR/PP interface [polypeptide binding]; other site
886293003366	TPP binding site [chemical binding]; other site
886293003367	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
886293003368	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
886293003369	TPP-binding site [chemical binding]; other site
886293003370	dimer interface [polypeptide binding]; other site
886293003371	purine nucleoside phosphorylase; Provisional; Region: PRK08202
886293003372	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
886293003373	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
886293003374	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
886293003375	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
886293003376	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
886293003377	active site
886293003378	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
886293003379	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
886293003380	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
886293003381	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
886293003382	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
886293003383	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
886293003384	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293003385	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
886293003386	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293003387	DNA binding residues [nucleotide binding]
886293003388	PilZ domain; Region: PilZ; pfam07238
886293003389	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293003390	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293003391	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
886293003392	Moco binding site; other site
886293003393	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135
886293003394	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
886293003395	fumarate hydratase; Reviewed; Region: fumC; PRK00485
886293003396	Class II fumarases; Region: Fumarase_classII; cd01362
886293003397	active site
886293003398	tetramer interface [polypeptide binding]; other site
886293003399	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
886293003400	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
886293003401	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293003402	TPR motif; other site
886293003403	binding surface
886293003404	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293003405	TPR motif; other site
886293003406	binding surface
886293003407	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
886293003408	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
886293003409	Cysteine-rich domain; Region: CCG; pfam02754
886293003410	Cysteine-rich domain; Region: CCG; pfam02754
886293003411	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
886293003412	FAD binding domain; Region: FAD_binding_4; pfam01565
886293003413	FAD binding domain; Region: FAD_binding_4; pfam01565
886293003414	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
886293003415	Domain of unknown function (DUF4393); Region: DUF4393; pfam14337
886293003416	DEAD-like helicases superfamily; Region: DEXDc; smart00487
886293003417	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
886293003418	ATP binding site [chemical binding]; other site
886293003419	putative Mg++ binding site [ion binding]; other site
886293003420	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293003421	nucleotide binding region [chemical binding]; other site
886293003422	ATP-binding site [chemical binding]; other site
886293003423	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
886293003424	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293003425	putative ADP-binding pocket [chemical binding]; other site
886293003426	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
886293003427	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
886293003428	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
886293003429	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
886293003430	Acyltransferase family; Region: Acyl_transf_3; pfam01757
886293003431	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
886293003432	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293003433	active site
886293003434	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293003435	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
886293003436	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
886293003437	active site
886293003438	Trehalose utilisation; Region: ThuA; pfam06283
886293003439	DDE superfamily endonuclease; Region: DDE_5; pfam13546
886293003440	AhpC/TSA family; Region: AhpC-TSA; pfam00578
886293003441	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293003442	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
886293003443	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
886293003444	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
886293003445	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
886293003446	Walker A/P-loop; other site
886293003447	ATP binding site [chemical binding]; other site
886293003448	Q-loop/lid; other site
886293003449	ABC transporter signature motif; other site
886293003450	Walker B; other site
886293003451	D-loop; other site
886293003452	H-loop/switch region; other site
886293003453	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
886293003454	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
886293003455	Ligand binding site; other site
886293003456	Putative Catalytic site; other site
886293003457	DXD motif; other site
886293003458	AAA ATPase domain; Region: AAA_16; pfam13191
886293003459	AAA domain; Region: AAA_22; pfam13401
886293003460	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
886293003461	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
886293003462	Walker A/P-loop; other site
886293003463	ATP binding site [chemical binding]; other site
886293003464	Q-loop/lid; other site
886293003465	ABC transporter signature motif; other site
886293003466	Walker B; other site
886293003467	D-loop; other site
886293003468	H-loop/switch region; other site
886293003469	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
886293003470	ABC-2 type transporter; Region: ABC2_membrane; cl17235
886293003471	ABC-2 type transporter; Region: ABC2_membrane; cl17235
886293003472	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
886293003473	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
886293003474	homodimer interface [polypeptide binding]; other site
886293003475	substrate-cofactor binding pocket; other site
886293003476	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293003477	catalytic residue [active]
886293003478	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
886293003479	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293003480	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293003481	catalytic residues [active]
886293003482	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293003483	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
886293003484	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293003485	active site
886293003486	phosphorylation site [posttranslational modification]
886293003487	intermolecular recognition site; other site
886293003488	dimerization interface [polypeptide binding]; other site
886293003489	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293003490	Walker A motif; other site
886293003491	ATP binding site [chemical binding]; other site
886293003492	Walker B motif; other site
886293003493	arginine finger; other site
886293003494	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
886293003495	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293003496	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
886293003497	Clp amino terminal domain; Region: Clp_N; pfam02861
886293003498	Clp amino terminal domain; Region: Clp_N; pfam02861
886293003499	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293003500	Walker A motif; other site
886293003501	ATP binding site [chemical binding]; other site
886293003502	Walker B motif; other site
886293003503	arginine finger; other site
886293003504	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293003505	Walker A motif; other site
886293003506	ATP binding site [chemical binding]; other site
886293003507	Walker B motif; other site
886293003508	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
886293003509	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
886293003510	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
886293003511	nucleotide binding site [chemical binding]; other site
886293003512	NEF interaction site [polypeptide binding]; other site
886293003513	SBD interface [polypeptide binding]; other site
886293003514	Chorismate mutase type II; Region: CM_2; smart00830
886293003515	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
886293003516	Prephenate dehydratase; Region: PDT; pfam00800
886293003517	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
886293003518	putative L-Phe binding site [chemical binding]; other site
886293003519	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
886293003520	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
886293003521	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
886293003522	triosephosphate isomerase; Provisional; Region: PRK14567
886293003523	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
886293003524	substrate binding site [chemical binding]; other site
886293003525	dimer interface [polypeptide binding]; other site
886293003526	catalytic triad [active]
886293003527	Preprotein translocase SecG subunit; Region: SecG; cl09123
886293003528	hypothetical protein; Provisional; Region: PRK11820
886293003529	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
886293003530	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
886293003531	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
886293003532	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
886293003533	catalytic site [active]
886293003534	G-X2-G-X-G-K; other site
886293003535	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; pfam01192
886293003536	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
886293003537	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
886293003538	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
886293003539	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
886293003540	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293003541	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293003542	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293003543	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293003544	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
886293003545	catalytic core [active]
886293003546	adenylate kinase; Region: adk; TIGR01351
886293003547	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
886293003548	AMP-binding site [chemical binding]; other site
886293003549	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
886293003550	OPT oligopeptide transporter protein; Region: OPT; cl14607
886293003551	OPT oligopeptide transporter protein; Region: OPT; cl14607
886293003552	Peptidase S46; Region: Peptidase_S46; pfam10459
886293003553	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293003554	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293003555	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293003556	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293003557	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293003558	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293003559	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293003560	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293003561	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293003562	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293003563	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293003564	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293003565	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
886293003566	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
886293003567	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293003568	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293003569	active site
886293003570	ATP binding site [chemical binding]; other site
886293003571	substrate binding site [chemical binding]; other site
886293003572	activation loop (A-loop); other site
886293003573	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
886293003574	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
886293003575	ligand binding site; other site
886293003576	oligomer interface; other site
886293003577	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293003578	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
886293003579	dimer interface [polypeptide binding]; other site
886293003580	N-terminal domain interface [polypeptide binding]; other site
886293003581	sulfate 1 binding site; other site
886293003582	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293003583	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
886293003584	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293003585	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293003586	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
886293003587	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293003588	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293003589	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293003590	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293003591	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293003592	structural tetrad; other site
886293003593	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
886293003594	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
886293003595	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
886293003596	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
886293003597	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
886293003598	active site
886293003599	Zn binding site [ion binding]; other site
886293003600	Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945
886293003601	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
886293003602	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
886293003603	ApbE family; Region: ApbE; pfam02424
886293003604	Predicted membrane protein [Function unknown]; Region: COG2259
886293003605	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293003606	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293003607	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
886293003608	Permease; Region: Permease; pfam02405
886293003609	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
886293003610	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
886293003611	Walker A/P-loop; other site
886293003612	ATP binding site [chemical binding]; other site
886293003613	Q-loop/lid; other site
886293003614	ABC transporter signature motif; other site
886293003615	Walker B; other site
886293003616	D-loop; other site
886293003617	H-loop/switch region; other site
886293003618	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
886293003619	mce related protein; Region: MCE; pfam02470
886293003620	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
886293003621	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
886293003622	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
886293003623	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
886293003624	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
886293003625	putative dimer interface [polypeptide binding]; other site
886293003626	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
886293003627	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
886293003628	RNA methyltransferase, RsmE family; Region: TIGR00046
886293003629	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
886293003630	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
886293003631	Putative phosphatase (DUF442); Region: DUF442; cl17385
886293003632	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
886293003633	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
886293003634	active site
886293003635	Uncharacterized conserved protein [Function unknown]; Region: COG0585
886293003636	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
886293003637	active site
886293003638	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
886293003639	competence damage-inducible protein A; Provisional; Region: PRK00549
886293003640	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
886293003641	putative MPT binding site; other site
886293003642	Competence-damaged protein; Region: CinA; pfam02464
886293003643	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
886293003644	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
886293003645	putative active site [active]
886293003646	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293003647	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293003648	catalytic residues [active]
886293003649	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293003650	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293003651	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293003652	DNA binding residues [nucleotide binding]
886293003653	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
886293003654	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
886293003655	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293003656	Walker A/P-loop; other site
886293003657	ATP binding site [chemical binding]; other site
886293003658	Q-loop/lid; other site
886293003659	ABC transporter signature motif; other site
886293003660	Walker B; other site
886293003661	D-loop; other site
886293003662	H-loop/switch region; other site
886293003663	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
886293003664	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
886293003665	Walker A/P-loop; other site
886293003666	ATP binding site [chemical binding]; other site
886293003667	Q-loop/lid; other site
886293003668	ABC transporter signature motif; other site
886293003669	Walker B; other site
886293003670	D-loop; other site
886293003671	H-loop/switch region; other site
886293003672	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
886293003673	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293003674	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293003675	protein binding site [polypeptide binding]; other site
886293003676	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293003677	DNA primase; Validated; Region: dnaG; PRK05667
886293003678	CHC2 zinc finger; Region: zf-CHC2; cl17510
886293003679	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
886293003680	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
886293003681	active site
886293003682	metal binding site [ion binding]; metal-binding site
886293003683	interdomain interaction site; other site
886293003684	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
886293003685	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
886293003686	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
886293003687	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293003688	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
886293003689	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293003690	DNA binding residues [nucleotide binding]
886293003691	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
886293003692	Putative zinc ribbon domain; Region: DUF164; pfam02591
886293003693	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
886293003694	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293003695	catalytic residues [active]
886293003696	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
886293003697	active site
886293003698	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
886293003699	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
886293003700	homotetramer interface [polypeptide binding]; other site
886293003701	ligand binding site [chemical binding]; other site
886293003702	catalytic site [active]
886293003703	NAD binding site [chemical binding]; other site
886293003704	Uncharacterized conserved protein [Function unknown]; Region: COG4198
886293003705	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
886293003706	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
886293003707	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
886293003708	active site
886293003709	substrate binding site [chemical binding]; other site
886293003710	cosubstrate binding site; other site
886293003711	catalytic site [active]
886293003712	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
886293003713	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
886293003714	[2Fe-2S] cluster binding site [ion binding]; other site
886293003715	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293003716	Coenzyme A binding pocket [chemical binding]; other site
886293003717	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
886293003718	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293003719	NAD(P) binding site [chemical binding]; other site
886293003720	active site
886293003721	acetolactate synthase; Region: PLN02470
886293003722	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
886293003723	PYR/PP interface [polypeptide binding]; other site
886293003724	dimer interface [polypeptide binding]; other site
886293003725	TPP binding site [chemical binding]; other site
886293003726	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
886293003727	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
886293003728	TPP-binding site [chemical binding]; other site
886293003729	dimer interface [polypeptide binding]; other site
886293003730	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
886293003731	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
886293003732	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
886293003733	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
886293003734	H+ Antiporter protein; Region: 2A0121; TIGR00900
886293003735	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293003736	putative substrate translocation pore; other site
886293003737	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
886293003738	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293003739	Major Facilitator Superfamily; Region: MFS_1; pfam07690
886293003740	putative substrate translocation pore; other site
886293003741	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293003742	Sulfatase; Region: Sulfatase; pfam00884
886293003743	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
886293003744	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
886293003745	active site
886293003746	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
886293003747	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
886293003748	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
886293003749	CCC1; Region: CCC1; cd02435
886293003750	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
886293003751	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
886293003752	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
886293003753	metal ion-dependent adhesion site (MIDAS); other site
886293003754	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
886293003755	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
886293003756	homodimer interface [polypeptide binding]; other site
886293003757	Walker A motif; other site
886293003758	ATP binding site [chemical binding]; other site
886293003759	hydroxycobalamin binding site [chemical binding]; other site
886293003760	Walker B motif; other site
886293003761	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
886293003762	dimer interface [polypeptide binding]; other site
886293003763	[2Fe-2S] cluster binding site [ion binding]; other site
886293003764	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
886293003765	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
886293003766	Uncharacterized conserved protein [Function unknown]; Region: COG3379
886293003767	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
886293003768	GH3 auxin-responsive promoter; Region: GH3; pfam03321
886293003769	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293003770	S-adenosylmethionine binding site [chemical binding]; other site
886293003771	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
886293003772	Putative serine esterase (DUF676); Region: DUF676; pfam05057
886293003773	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
886293003774	TIGR01777 family protein; Region: yfcH
886293003775	putative NAD(P) binding site [chemical binding]; other site
886293003776	putative active site [active]
886293003777	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
886293003778	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
886293003779	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293003780	homodimer interface [polypeptide binding]; other site
886293003781	catalytic residue [active]
886293003782	cobyric acid synthase; Provisional; Region: PRK00784
886293003783	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
886293003784	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
886293003785	catalytic triad [active]
886293003786	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
886293003787	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
886293003788	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
886293003789	putative active site [active]
886293003790	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
886293003791	putative active site [active]
886293003792	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
886293003793	active site
886293003794	SAM binding site [chemical binding]; other site
886293003795	homodimer interface [polypeptide binding]; other site
886293003796	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
886293003797	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
886293003798	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877
886293003799	Peptidase family M28; Region: Peptidase_M28; pfam04389
886293003800	metal binding site [ion binding]; metal-binding site
886293003801	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
886293003802	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293003803	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293003804	active site
886293003805	ATP binding site [chemical binding]; other site
886293003806	substrate binding site [chemical binding]; other site
886293003807	activation loop (A-loop); other site
886293003808	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293003809	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293003810	structural tetrad; other site
886293003811	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293003812	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293003813	structural tetrad; other site
886293003814	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293003815	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293003816	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
886293003817	homodimer interface [polypeptide binding]; other site
886293003818	active site
886293003819	SAM binding site [chemical binding]; other site
886293003820	Precorrin-8X methylmutase; Region: CbiC; pfam02570
886293003821	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
886293003822	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
886293003823	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
886293003824	active site
886293003825	putative homodimer interface [polypeptide binding]; other site
886293003826	SAM binding site [chemical binding]; other site
886293003827	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
886293003828	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293003829	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293003830	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293003831	active site
886293003832	ATP binding site [chemical binding]; other site
886293003833	substrate binding site [chemical binding]; other site
886293003834	activation loop (A-loop); other site
886293003835	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
886293003836	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
886293003837	active site
886293003838	ADP/pyrophosphate binding site [chemical binding]; other site
886293003839	allosteric effector site; other site
886293003840	dimerization interface [polypeptide binding]; other site
886293003841	fructose-1,6-bisphosphate binding site; other site
886293003842	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
886293003843	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
886293003844	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
886293003845	Peptidase family M48; Region: Peptidase_M48; cl12018
886293003846	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293003847	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293003848	active site
886293003849	ATP binding site [chemical binding]; other site
886293003850	substrate binding site [chemical binding]; other site
886293003851	activation loop (A-loop); other site
886293003852	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
886293003853	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
886293003854	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293003855	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293003856	Interdomain contacts; other site
886293003857	Cytokine receptor motif; other site
886293003858	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
886293003859	active site
886293003860	catalytic residues [active]
886293003861	DNA binding site [nucleotide binding]
886293003862	Int/Topo IB signature motif; other site
886293003863	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
886293003864	active site
886293003865	metal binding site [ion binding]; metal-binding site
886293003866	interdomain interaction site; other site
886293003867	Helix-turn-helix; Region: HTH_3; pfam01381
886293003868	Domain of unknown function (DUF4325); Region: DUF4325; pfam14213
886293003869	Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293
886293003870	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293003871	non-specific DNA binding site [nucleotide binding]; other site
886293003872	salt bridge; other site
886293003873	sequence-specific DNA binding site [nucleotide binding]; other site
886293003874	DDE superfamily endonuclease; Region: DDE_5; pfam13546
886293003875	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293003876	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
886293003877	putative active site [active]
886293003878	heme pocket [chemical binding]; other site
886293003879	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
886293003880	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293003881	putative active site [active]
886293003882	heme pocket [chemical binding]; other site
886293003883	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293003884	dimer interface [polypeptide binding]; other site
886293003885	phosphorylation site [posttranslational modification]
886293003886	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293003887	ATP binding site [chemical binding]; other site
886293003888	Mg2+ binding site [ion binding]; other site
886293003889	G-X-G motif; other site
886293003890	Response regulator receiver domain; Region: Response_reg; pfam00072
886293003891	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293003892	active site
886293003893	phosphorylation site [posttranslational modification]
886293003894	intermolecular recognition site; other site
886293003895	dimerization interface [polypeptide binding]; other site
886293003896	Lsr2; Region: Lsr2; pfam11774
886293003897	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
886293003898	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
886293003899	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
886293003900	dimer interface [polypeptide binding]; other site
886293003901	active site
886293003902	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293003903	putative substrate translocation pore; other site
886293003904	Major Facilitator Superfamily; Region: MFS_1; pfam07690
886293003905	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
886293003906	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
886293003907	classical (c) SDRs; Region: SDR_c; cd05233
886293003908	NAD(P) binding site [chemical binding]; other site
886293003909	active site
886293003910	Uncharacterized conserved protein [Function unknown]; Region: COG2128
886293003911	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
886293003912	tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238
886293003913	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
886293003914	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
886293003915	catalytic residue [active]
886293003916	acetyl-CoA synthetase; Provisional; Region: PRK00174
886293003917	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
886293003918	Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968
886293003919	acyl-activating enzyme (AAE) consensus motif; other site
886293003920	putative active site [active]
886293003921	putative AMP binding site [chemical binding]; other site
886293003922	putative CoA binding site [chemical binding]; other site
886293003923	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
886293003924	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293003925	Sulfatase; Region: Sulfatase; pfam00884
886293003926	Uncharacterized conserved protein [Function unknown]; Region: COG3379
886293003927	Uncharacterized conserved protein [Function unknown]; Region: COG3379
886293003928	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
886293003929	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
886293003930	B12 binding site [chemical binding]; other site
886293003931	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
886293003932	FeS/SAM binding site; other site
886293003933	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
886293003934	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
886293003935	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
886293003936	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293003937	S-adenosylmethionine binding site [chemical binding]; other site
886293003938	aromatic acid decarboxylase; Validated; Region: PRK05920
886293003939	Flavoprotein; Region: Flavoprotein; pfam02441
886293003940	short chain dehydrogenase; Provisional; Region: PRK08251
886293003941	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293003942	NAD(P) binding site [chemical binding]; other site
886293003943	active site
886293003944	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
886293003945	UbiA prenyltransferase family; Region: UbiA; pfam01040
886293003946	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
886293003947	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293003948	binding surface
886293003949	TPR motif; other site
886293003950	Family description; Region: VCBS; pfam13517
886293003951	Family description; Region: VCBS; pfam13517
886293003952	Family description; Region: VCBS; pfam13517
886293003953	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
886293003954	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
886293003955	Predicted amidohydrolase [General function prediction only]; Region: COG0388
886293003956	active site
886293003957	catalytic triad [active]
886293003958	dimer interface [polypeptide binding]; other site
886293003959	TPR repeat; Region: TPR_11; pfam13414
886293003960	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293003961	TPR motif; other site
886293003962	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293003963	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293003964	active site
886293003965	ATP binding site [chemical binding]; other site
886293003966	substrate binding site [chemical binding]; other site
886293003967	activation loop (A-loop); other site
886293003968	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293003969	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
886293003970	NAD(P) binding site [chemical binding]; other site
886293003971	active site
886293003972	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293003973	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293003974	Transcription factor Tfb2; Region: Tfb2; cl04289
886293003975	carbon storage regulator; Provisional; Region: PRK01712
886293003976	intracellular protease, PfpI family; Region: PfpI; TIGR01382
886293003977	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
886293003978	conserved cys residue [active]
886293003979	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
886293003980	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
886293003981	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
886293003982	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
886293003983	active site
886293003984	Zn binding site [ion binding]; other site
886293003985	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
886293003986	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
886293003987	active site
886293003988	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
886293003989	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
886293003990	P-loop; other site
886293003991	Magnesium ion binding site [ion binding]; other site
886293003992	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
886293003993	Magnesium ion binding site [ion binding]; other site
886293003994	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
886293003995	ParB-like nuclease domain; Region: ParB; smart00470
886293003996	KorB domain; Region: KorB; pfam08535
886293003997	Response regulator receiver domain; Region: Response_reg; pfam00072
886293003998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293003999	active site
886293004000	phosphorylation site [posttranslational modification]
886293004001	intermolecular recognition site; other site
886293004002	dimerization interface [polypeptide binding]; other site
886293004003	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
886293004004	tetramer (dimer of dimers) interface [polypeptide binding]; other site
886293004005	active site
886293004006	dimer interface [polypeptide binding]; other site
886293004007	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
886293004008	intersubunit interface [polypeptide binding]; other site
886293004009	active site
886293004010	catalytic residue [active]
886293004011	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
886293004012	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
886293004013	dimerization interface [polypeptide binding]; other site
886293004014	active site
886293004015	metal binding site [ion binding]; metal-binding site
886293004016	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
886293004017	dsRNA binding site [nucleotide binding]; other site
886293004018	elongation factor P; Provisional; Region: PRK04542
886293004019	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
886293004020	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
886293004021	RNA binding site [nucleotide binding]; other site
886293004022	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
886293004023	RNA binding site [nucleotide binding]; other site
886293004024	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
886293004025	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
886293004026	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
886293004027	DNA binding site [nucleotide binding]
886293004028	active site
886293004029	Transport protein; Region: actII; TIGR00833
886293004030	Peptidase family M48; Region: Peptidase_M48; pfam01435
886293004031	JAB/MPN domain; Region: JAB_MPN; smart00232
886293004032	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
886293004033	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
886293004034	ATP binding site [chemical binding]; other site
886293004035	substrate interface [chemical binding]; other site
886293004036	Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; Region: UBCc; cl00154
886293004037	E3 interaction residues; other site
886293004038	Ub thioester intermediate interaction residues; other site
886293004039	active site cysteine
886293004040	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817
886293004041	Prokaryotic RING finger family 1; Region: Prok-RING_1; pfam14446
886293004042	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
886293004043	EamA-like transporter family; Region: EamA; pfam00892
886293004044	EamA-like transporter family; Region: EamA; pfam00892
886293004045	threonine synthase; Validated; Region: PRK08197
886293004046	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
886293004047	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
886293004048	catalytic residue [active]
886293004049	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
886293004050	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293004051	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293004052	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293004053	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
886293004054	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
886293004055	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293004056	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293004057	Cna protein B-type domain; Region: Cna_B_2; pfam13715
886293004058	Predicted membrane protein [Function unknown]; Region: COG3059
886293004059	Helix-turn-helix domain; Region: HTH_18; pfam12833
886293004060	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293004061	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
886293004062	TatD related DNase; Region: TatD_DNase; pfam01026
886293004063	active site
886293004064	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293004065	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
886293004066	UbiA prenyltransferase family; Region: UbiA; pfam01040
886293004067	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293004068	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
886293004069	DNA interaction; other site
886293004070	Metal-binding active site; metal-binding site
886293004071	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
886293004072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
886293004073	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293004074	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
886293004075	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293004076	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
886293004077	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
886293004078	Walker A/P-loop; other site
886293004079	ATP binding site [chemical binding]; other site
886293004080	Q-loop/lid; other site
886293004081	ABC transporter signature motif; other site
886293004082	Walker B; other site
886293004083	D-loop; other site
886293004084	H-loop/switch region; other site
886293004085	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
886293004086	FtsX-like permease family; Region: FtsX; pfam02687
886293004087	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
886293004088	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
886293004089	FtsX-like permease family; Region: FtsX; pfam02687
886293004090	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
886293004091	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
886293004092	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293004093	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293004094	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293004095	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293004096	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293004097	L-lactate dehydrogenase-like enzymes; Region: LDH_like; cd00300
886293004098	Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039
886293004099	dimer interface [polypeptide binding]; other site
886293004100	NAD(P) binding site [chemical binding]; other site
886293004101	tetramer (dimer of dimers) interface [polypeptide binding]; other site
886293004102	substrate binding site [chemical binding]; other site
886293004103	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
886293004104	intersubunit interface [polypeptide binding]; other site
886293004105	active site
886293004106	Zn2+ binding site [ion binding]; other site
886293004107	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
886293004108	Hexamer/Pentamer interface [polypeptide binding]; other site
886293004109	central pore; other site
886293004110	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
886293004111	Hexamer/Pentamer interface [polypeptide binding]; other site
886293004112	central pore; other site
886293004113	aldehyde dehydrogenase EutE; Provisional; Region: PRK15398
886293004114	NAD(P) binding site [chemical binding]; other site
886293004115	catalytic residues [active]
886293004116	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
886293004117	Hexamer/Pentamer interface [polypeptide binding]; other site
886293004118	central pore; other site
886293004119	Acetokinase family; Region: Acetate_kinase; cl17229
886293004120	propionate/acetate kinase; Provisional; Region: PRK12379
886293004121	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
886293004122	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
886293004123	Hexamer interface [polypeptide binding]; other site
886293004124	Hexagonal pore residue; other site
886293004125	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
886293004126	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
886293004127	Hexamer interface [polypeptide binding]; other site
886293004128	Hexagonal pore residue; other site
886293004129	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
886293004130	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
886293004131	Hexamer interface [polypeptide binding]; other site
886293004132	Hexagonal pore residue; other site
886293004133	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
886293004134	Propanediol utilisation protein PduL; Region: PduL; pfam06130
886293004135	Propanediol utilisation protein PduL; Region: PduL; pfam06130
886293004136	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
886293004137	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
886293004138	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
886293004139	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
886293004140	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
886293004141	DNA binding site [nucleotide binding]
886293004142	catalytic residue [active]
886293004143	H2TH interface [polypeptide binding]; other site
886293004144	putative catalytic residues [active]
886293004145	turnover-facilitating residue; other site
886293004146	intercalation triad [nucleotide binding]; other site
886293004147	8OG recognition residue [nucleotide binding]; other site
886293004148	putative reading head residues; other site
886293004149	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
886293004150	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
886293004151	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
886293004152	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293004153	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
886293004154	dimerization interface [polypeptide binding]; other site
886293004155	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293004156	dimer interface [polypeptide binding]; other site
886293004157	phosphorylation site [posttranslational modification]
886293004158	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293004159	ATP binding site [chemical binding]; other site
886293004160	Mg2+ binding site [ion binding]; other site
886293004161	G-X-G motif; other site
886293004162	FtsH Extracellular; Region: FtsH_ext; pfam06480
886293004163	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
886293004164	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293004165	Walker A motif; other site
886293004166	ATP binding site [chemical binding]; other site
886293004167	Walker B motif; other site
886293004168	arginine finger; other site
886293004169	Peptidase family M41; Region: Peptidase_M41; pfam01434
886293004170	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
886293004171	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
886293004172	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
886293004173	metal ion-dependent adhesion site (MIDAS); other site
886293004174	PilZ domain; Region: PilZ; pfam07238
886293004175	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293004176	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
886293004177	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
886293004178	Double zinc ribbon; Region: DZR; pfam12773
886293004179	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
886293004180	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
886293004181	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
886293004182	nucleotide binding site [chemical binding]; other site
886293004183	Protein of unknown function (DUF1444); Region: DUF1444; cl02011
886293004184	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
886293004185	sulfite oxidase; Provisional; Region: PLN00177
886293004186	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
886293004187	Moco binding site; other site
886293004188	metal coordination site [ion binding]; other site
886293004189	dimerization interface [polypeptide binding]; other site
886293004190	Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
886293004191	HDOD domain; Region: HDOD; pfam08668
886293004192	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
886293004193	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293004194	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293004195	dimer interface [polypeptide binding]; other site
886293004196	phosphorylation site [posttranslational modification]
886293004197	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293004198	ATP binding site [chemical binding]; other site
886293004199	Mg2+ binding site [ion binding]; other site
886293004200	G-X-G motif; other site
886293004201	Helix-turn-helix domain; Region: HTH_17; pfam12728
886293004202	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293004203	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293004204	active site
886293004205	phosphorylation site [posttranslational modification]
886293004206	intermolecular recognition site; other site
886293004207	dimerization interface [polypeptide binding]; other site
886293004208	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
886293004209	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
886293004210	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
886293004211	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
886293004212	dimer interface [polypeptide binding]; other site
886293004213	catalytic triad [active]
886293004214	peroxidatic and resolving cysteines [active]
886293004215	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
886293004216	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
886293004217	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
886293004218	active site
886293004219	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293004220	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
886293004221	BON domain; Region: BON; pfam04972
886293004222	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
886293004223	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
886293004224	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
886293004225	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
886293004226	dimer interface [polypeptide binding]; other site
886293004227	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
886293004228	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
886293004229	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
886293004230	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
886293004231	metal ion-dependent adhesion site (MIDAS); other site
886293004232	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
886293004233	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
886293004234	nucleotide binding site [chemical binding]; other site
886293004235	putative NEF/HSP70 interaction site [polypeptide binding]; other site
886293004236	SBD interface [polypeptide binding]; other site
886293004237	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
886293004238	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
886293004239	nucleotide binding site [chemical binding]; other site
886293004240	putative NEF/HSP70 interaction site [polypeptide binding]; other site
886293004241	SBD interface [polypeptide binding]; other site
886293004242	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
886293004243	metal ion-dependent adhesion site (MIDAS); other site
886293004244	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293004245	phosphopeptide binding site; other site
886293004246	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293004247	phosphopeptide binding site; other site
886293004248	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
886293004249	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
886293004250	metal ion-dependent adhesion site (MIDAS); other site
886293004251	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
886293004252	DDE superfamily endonuclease; Region: DDE_5; cl17874
886293004253	recombination factor protein RarA; Reviewed; Region: PRK13342
886293004254	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293004255	Walker A motif; other site
886293004256	ATP binding site [chemical binding]; other site
886293004257	Walker B motif; other site
886293004258	arginine finger; other site
886293004259	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
886293004260	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
886293004261	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
886293004262	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
886293004263	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
886293004264	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
886293004265	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
886293004266	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
886293004267	iron-sulfur cluster [ion binding]; other site
886293004268	[2Fe-2S] cluster binding site [ion binding]; other site
886293004269	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
886293004270	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
886293004271	heme bH binding site [chemical binding]; other site
886293004272	intrachain domain interface; other site
886293004273	Qi binding site; other site
886293004274	heme bL binding site [chemical binding]; other site
886293004275	interchain domain interface [polypeptide binding]; other site
886293004276	Qo binding site; other site
886293004277	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
886293004278	Cytochrome c; Region: Cytochrom_C; pfam00034
886293004279	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293004280	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293004281	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
886293004282	Trp docking motif [polypeptide binding]; other site
886293004283	active site
886293004284	PQQ-like domain; Region: PQQ_2; pfam13360
886293004285	Tetratricopeptide repeat; Region: TPR_16; pfam13432
886293004286	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
886293004287	MoxR-like ATPases [General function prediction only]; Region: COG0714
886293004288	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293004289	Walker A motif; other site
886293004290	ATP binding site [chemical binding]; other site
886293004291	Walker B motif; other site
886293004292	arginine finger; other site
886293004293	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
886293004294	Protein of unknown function DUF58; Region: DUF58; pfam01882
886293004295	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
886293004296	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
886293004297	metal ion-dependent adhesion site (MIDAS); other site
886293004298	CARDB; Region: CARDB; pfam07705
886293004299	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
886293004300	metal ion-dependent adhesion site (MIDAS); other site
886293004301	Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795
886293004302	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
886293004303	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293004304	Prenyltransferase-like; Region: Prenyltrans_1; pfam13243
886293004305	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
886293004306	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293004307	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293004308	ATP binding site [chemical binding]; other site
886293004309	Mg2+ binding site [ion binding]; other site
886293004310	G-X-G motif; other site
886293004311	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293004312	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
886293004313	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293004314	ATP binding site [chemical binding]; other site
886293004315	Mg2+ binding site [ion binding]; other site
886293004316	G-X-G motif; other site
886293004317	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
886293004318	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293004319	active site
886293004320	phosphorylation site [posttranslational modification]
886293004321	intermolecular recognition site; other site
886293004322	dimerization interface [polypeptide binding]; other site
886293004323	ANTAR domain; Region: ANTAR; pfam03861
886293004324	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
886293004325	active site 2 [active]
886293004326	active site 1 [active]
886293004327	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370
886293004328	hypothetical protein; Provisional; Region: PRK02399
886293004329	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
886293004330	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
886293004331	classical (c) SDRs; Region: SDR_c; cd05233
886293004332	NAD(P) binding site [chemical binding]; other site
886293004333	active site
886293004334	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293004335	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
886293004336	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293004337	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293004338	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
886293004339	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
886293004340	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
886293004341	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
886293004342	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
886293004343	PA/protease or protease-like domain interface [polypeptide binding]; other site
886293004344	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
886293004345	metal binding site [ion binding]; metal-binding site
886293004346	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
886293004347	Haem-binding domain; Region: Haem_bd; pfam14376
886293004348	Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712
886293004349	multidrug efflux protein; Reviewed; Region: PRK09577
886293004350	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
886293004351	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293004352	dimer interface [polypeptide binding]; other site
886293004353	phosphorylation site [posttranslational modification]
886293004354	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293004355	ATP binding site [chemical binding]; other site
886293004356	Mg2+ binding site [ion binding]; other site
886293004357	G-X-G motif; other site
886293004358	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
886293004359	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293004360	active site
886293004361	phosphorylation site [posttranslational modification]
886293004362	intermolecular recognition site; other site
886293004363	dimerization interface [polypeptide binding]; other site
886293004364	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293004365	Walker A motif; other site
886293004366	ATP binding site [chemical binding]; other site
886293004367	Walker B motif; other site
886293004368	arginine finger; other site
886293004369	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
886293004370	putative dimer interface [polypeptide binding]; other site
886293004371	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
886293004372	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293004373	dimerization interface [polypeptide binding]; other site
886293004374	putative DNA binding site [nucleotide binding]; other site
886293004375	putative Zn2+ binding site [ion binding]; other site
886293004376	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826
886293004377	putative hydrophobic ligand binding site [chemical binding]; other site
886293004378	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
886293004379	short chain dehydrogenase; Provisional; Region: PRK06500
886293004380	classical (c) SDRs; Region: SDR_c; cd05233
886293004381	NAD(P) binding site [chemical binding]; other site
886293004382	active site
886293004383	Predicted transcriptional regulators [Transcription]; Region: COG1733
886293004384	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
886293004385	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
886293004386	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
886293004387	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
886293004388	FIST N domain; Region: FIST; pfam08495
886293004389	FIST C domain; Region: FIST_C; pfam10442
886293004390	Protein of unknown function (DUF1574); Region: DUF1574; pfam07611
886293004391	GTP-binding protein LepA; Provisional; Region: PRK05433
886293004392	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
886293004393	G1 box; other site
886293004394	putative GEF interaction site [polypeptide binding]; other site
886293004395	GTP/Mg2+ binding site [chemical binding]; other site
886293004396	Switch I region; other site
886293004397	G2 box; other site
886293004398	G3 box; other site
886293004399	Switch II region; other site
886293004400	G4 box; other site
886293004401	G5 box; other site
886293004402	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
886293004403	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
886293004404	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
886293004405	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
886293004406	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
886293004407	Catalytic site [active]
886293004408	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
886293004409	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
886293004410	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
886293004411	Catalytic site [active]
886293004412	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
886293004413	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
886293004414	Walker A/P-loop; other site
886293004415	ATP binding site [chemical binding]; other site
886293004416	Q-loop/lid; other site
886293004417	ABC transporter signature motif; other site
886293004418	Walker B; other site
886293004419	D-loop; other site
886293004420	H-loop/switch region; other site
886293004421	Protein of unknown function (DUF1579); Region: DUF1579; pfam07617
886293004422	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293004423	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293004424	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293004425	active site
886293004426	ATP binding site [chemical binding]; other site
886293004427	substrate binding site [chemical binding]; other site
886293004428	activation loop (A-loop); other site
886293004429	RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984
886293004430	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293004431	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293004432	DNA binding residues [nucleotide binding]
886293004433	DNA polymerase II large subunit; Provisional; Region: PRK14714
886293004434	Protein of unknown function, DUF393; Region: DUF393; cl01136
886293004435	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
886293004436	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
886293004437	substrate binding site [chemical binding]; other site
886293004438	active site
886293004439	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
886293004440	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293004441	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
886293004442	Peptidase family M50; Region: Peptidase_M50; pfam02163
886293004443	active site
886293004444	putative substrate binding region [chemical binding]; other site
886293004445	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293004446	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
886293004447	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
886293004448	active site
886293004449	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
886293004450	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
886293004451	substrate binding pocket [chemical binding]; other site
886293004452	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293004453	Response regulator receiver domain; Region: Response_reg; pfam00072
886293004454	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293004455	active site
886293004456	phosphorylation site [posttranslational modification]
886293004457	intermolecular recognition site; other site
886293004458	dimerization interface [polypeptide binding]; other site
886293004459	L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196
886293004460	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293004461	binding surface
886293004462	TPR motif; other site
886293004463	TPR repeat; Region: TPR_11; pfam13414
886293004464	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
886293004465	Methyltransferase domain; Region: Methyltransf_31; pfam13847
886293004466	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293004467	S-adenosylmethionine binding site [chemical binding]; other site
886293004468	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
886293004469	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
886293004470	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
886293004471	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293004472	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293004473	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293004474	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293004475	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
886293004476	dimer interface [polypeptide binding]; other site
886293004477	conserved gate region; other site
886293004478	putative PBP binding loops; other site
886293004479	ABC-ATPase subunit interface; other site
886293004480	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
886293004481	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
886293004482	active site
886293004483	HIGH motif; other site
886293004484	KMSKS motif; other site
886293004485	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
886293004486	tRNA binding surface [nucleotide binding]; other site
886293004487	anticodon binding site; other site
886293004488	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
886293004489	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
886293004490	tetramerization interface [polypeptide binding]; other site
886293004491	NAD(P) binding site [chemical binding]; other site
886293004492	catalytic residues [active]
886293004493	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
886293004494	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
886293004495	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
886293004496	Methyltransferase domain; Region: Methyltransf_31; pfam13847
886293004497	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293004498	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
886293004499	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
886293004500	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
886293004501	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
886293004502	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293004503	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293004504	Family description; Region: VCBS; pfam13517
886293004505	Family description; Region: VCBS; pfam13517
886293004506	Family description; Region: VCBS; pfam13517
886293004507	Family description; Region: VCBS; pfam13517
886293004508	Family description; Region: VCBS; pfam13517
886293004509	Uncharacterized conserved protein [Function unknown]; Region: COG2006
886293004510	Domain of unknown function (DUF362); Region: DUF362; pfam04015
886293004511	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293004512	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
886293004513	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
886293004514	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
886293004515	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
886293004516	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
886293004517	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
886293004518	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
886293004519	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
886293004520	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
886293004521	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
886293004522	ATP binding site [chemical binding]; other site
886293004523	Walker A motif; other site
886293004524	hexamer interface [polypeptide binding]; other site
886293004525	Walker B motif; other site
886293004526	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
886293004527	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
886293004528	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
886293004529	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
886293004530	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
886293004531	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
886293004532	active site residue [active]
886293004533	RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989
886293004534	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293004535	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
886293004536	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
886293004537	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
886293004538	active site
886293004539	catalytic residues [active]
886293004540	DNA binding site [nucleotide binding]
886293004541	Int/Topo IB signature motif; other site
886293004542	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
886293004543	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
886293004544	ATP binding site [chemical binding]; other site
886293004545	putative Mg++ binding site [ion binding]; other site
886293004546	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293004547	nucleotide binding region [chemical binding]; other site
886293004548	ATP-binding site [chemical binding]; other site
886293004549	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
886293004550	PglZ domain; Region: PglZ; pfam08665
886293004551	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
886293004552	oligomeric interface; other site
886293004553	putative active site [active]
886293004554	homodimer interface [polypeptide binding]; other site
886293004555	Methyltransferase domain; Region: Methyltransf_26; pfam13659
886293004556	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
886293004557	Nuclease-related domain; Region: NERD; pfam08378
886293004558	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293004559	active site
886293004560	ATP binding site [chemical binding]; other site
886293004561	substrate binding site [chemical binding]; other site
886293004562	activation loop (A-loop); other site
886293004563	Protein kinase domain; Region: Pkinase; pfam00069
886293004564	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293004565	active site
886293004566	ATP binding site [chemical binding]; other site
886293004567	substrate binding site [chemical binding]; other site
886293004568	activation loop (A-loop); other site
886293004569	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
886293004570	Protein of unknown function (DUF1257); Region: DUF1257; cl06088
886293004571	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
886293004572	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
886293004573	catalytic residues [active]
886293004574	catalytic nucleophile [active]
886293004575	Recombinase; Region: Recombinase; pfam07508
886293004576	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
886293004577	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
886293004578	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293004579	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293004580	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293004581	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
886293004582	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
886293004583	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
886293004584	catalytic residues [active]
886293004585	catalytic nucleophile [active]
886293004586	Recombinase; Region: Recombinase; pfam07508
886293004587	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
886293004588	DNA binding residues [nucleotide binding]
886293004589	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
886293004590	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
886293004591	putative active site [active]
886293004592	putative NTP binding site [chemical binding]; other site
886293004593	putative nucleic acid binding site [nucleotide binding]; other site
886293004594	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
886293004595	Walker A motif; other site
886293004596	ATP binding site [chemical binding]; other site
886293004597	Walker B motif; other site
886293004598	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
886293004599	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
886293004600	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
886293004601	DDE domain; Region: DDE_Tnp_IS240; pfam13610
886293004602	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
886293004603	CsbD-like; Region: CsbD; cl17424
886293004604	Predicted membrane protein [Function unknown]; Region: COG1470
886293004605	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
886293004606	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
886293004607	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
886293004608	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
886293004609	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
886293004610	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293004611	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
886293004612	BON domain; Region: BON; pfam04972
886293004613	BON domain; Region: BON; pfam04972
886293004614	BON domain; Region: BON; pfam04972
886293004615	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
886293004616	Ion channel; Region: Ion_trans_2; pfam07885
886293004617	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
886293004618	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
886293004619	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
886293004620	Eukaryotic phosphomannomutase; Region: PMM; cl17107
886293004621	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
886293004622	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
886293004623	active site
886293004624	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
886293004625	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
886293004626	TPP-binding site [chemical binding]; other site
886293004627	dimer interface [polypeptide binding]; other site
886293004628	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
886293004629	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
886293004630	PYR/PP interface [polypeptide binding]; other site
886293004631	dimer interface [polypeptide binding]; other site
886293004632	TPP binding site [chemical binding]; other site
886293004633	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
886293004634	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
886293004635	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
886293004636	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
886293004637	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
886293004638	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
886293004639	putative active site [active]
886293004640	catalytic residue [active]
886293004641	alternate F1F0 ATPase, F1 subunit beta; Region: alt_F1F0_F1_bet; TIGR03305
886293004642	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
886293004643	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
886293004644	alpha subunit interaction interface [polypeptide binding]; other site
886293004645	Walker A motif; other site
886293004646	ATP binding site [chemical binding]; other site
886293004647	Walker B motif; other site
886293004648	inhibitor binding site; inhibition site
886293004649	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
886293004650	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
886293004651	F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228
886293004652	LBP interface [polypeptide binding]; other site
886293004653	epsilon subunit interface [polypeptide binding]; other site
886293004654	gamma subunit interface [polypeptide binding]; other site
886293004655	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
886293004656	F1/F0 ATPase, Methanosarcina type, subunit 2; Region: F1F0_chp_2; TIGR03165
886293004657	alternate F1F0 ATPase, F0 subunit A; Region: altF1_A; TIGR03306
886293004658	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
886293004659	alternate F1F0 ATPase, F0 subunit C; Region: alt_F1F0_F0_C; TIGR03322
886293004660	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
886293004661	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
886293004662	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293004663	alternate F1F0 ATPase, F1 subunit alpha; Region: alt_F1F0_F1_al; TIGR03324
886293004664	active site
886293004665	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
886293004666	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
886293004667	Walker A motif; other site
886293004668	ATP binding site [chemical binding]; other site
886293004669	Walker B motif; other site
886293004670	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
886293004671	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
886293004672	core domain interface [polypeptide binding]; other site
886293004673	delta subunit interface [polypeptide binding]; other site
886293004674	epsilon subunit interface [polypeptide binding]; other site
886293004675	propionate/acetate kinase; Provisional; Region: PRK12379
886293004676	Acetokinase family; Region: Acetate_kinase; cl17229
886293004677	putative phosphoketolase; Provisional; Region: PRK05261
886293004678	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
886293004679	TPP-binding site; other site
886293004680	XFP C-terminal domain; Region: XFP_C; pfam09363
886293004681	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
886293004682	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
886293004683	catalytic residues [active]
886293004684	catalytic nucleophile [active]
886293004685	Recombinase; Region: Recombinase; pfam07508
886293004686	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
886293004687	Helix-turn-helix domain; Region: HTH_17; cl17695
886293004688	DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033
886293004689	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
886293004690	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
886293004691	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
886293004692	hypothetical protein; Provisional; Region: PRK06834
886293004693	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
886293004694	Cupin domain; Region: Cupin_2; cl17218
886293004695	Helix-turn-helix domain; Region: HTH_18; pfam12833
886293004696	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293004697	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
886293004698	Methyltransferase domain; Region: Methyltransf_24; pfam13578
886293004699	Cupin domain; Region: Cupin_2; cl17218
886293004700	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
886293004701	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
886293004702	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293004703	Walker A/P-loop; other site
886293004704	ATP binding site [chemical binding]; other site
886293004705	Q-loop/lid; other site
886293004706	ABC transporter signature motif; other site
886293004707	Walker B; other site
886293004708	D-loop; other site
886293004709	H-loop/switch region; other site
886293004710	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
886293004711	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
886293004712	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
886293004713	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
886293004714	EamA-like transporter family; Region: EamA; pfam00892
886293004715	EamA-like transporter family; Region: EamA; pfam00892
886293004716	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
886293004717	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293004718	putative DNA binding site [nucleotide binding]; other site
886293004719	putative Zn2+ binding site [ion binding]; other site
886293004720	AsnC family; Region: AsnC_trans_reg; pfam01037
886293004721	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
886293004722	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
886293004723	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
886293004724	acyl-activating enzyme (AAE) consensus motif; other site
886293004725	AMP binding site [chemical binding]; other site
886293004726	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
886293004727	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
886293004728	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
886293004729	active site
886293004730	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
886293004731	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
886293004732	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293004733	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
886293004734	Enoylreductase; Region: PKS_ER; smart00829
886293004735	NAD(P) binding site [chemical binding]; other site
886293004736	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
886293004737	KR domain; Region: KR; pfam08659
886293004738	putative NADP binding site [chemical binding]; other site
886293004739	active site
886293004740	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
886293004741	Putative ammonia monooxygenase; Region: AmoA; pfam05145
886293004742	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
886293004743	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
886293004744	Isochorismatase family; Region: Isochorismatase; pfam00857
886293004745	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
886293004746	catalytic triad [active]
886293004747	conserved cis-peptide bond; other site
886293004748	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
886293004749	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
886293004750	FtsX-like permease family; Region: FtsX; pfam02687
886293004751	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
886293004752	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
886293004753	Walker A/P-loop; other site
886293004754	ATP binding site [chemical binding]; other site
886293004755	Q-loop/lid; other site
886293004756	ABC transporter signature motif; other site
886293004757	Walker B; other site
886293004758	D-loop; other site
886293004759	H-loop/switch region; other site
886293004760	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
886293004761	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
886293004762	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293004763	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
886293004764	Predicted transcriptional regulators [Transcription]; Region: COG1733
886293004765	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
886293004766	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
886293004767	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293004768	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293004769	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293004770	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
886293004771	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
886293004772	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293004773	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
886293004774	EF-hand domain pair; Region: EF_hand_5; pfam13499
886293004775	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
886293004776	Ca2+ binding site [ion binding]; other site
886293004777	Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459
886293004778	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
886293004779	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293004780	ATP binding site [chemical binding]; other site
886293004781	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293004782	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293004783	substrate binding site [chemical binding]; other site
886293004784	activation loop (A-loop); other site
886293004785	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293004786	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293004787	binding surface
886293004788	TPR motif; other site
886293004789	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293004790	RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984
886293004791	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293004792	DNA binding residues [nucleotide binding]
886293004793	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
886293004794	Beta-lactamase; Region: Beta-lactamase; pfam00144
886293004795	Transcriptional regulators [Transcription]; Region: GntR; COG1802
886293004796	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
886293004797	DNA-binding site [nucleotide binding]; DNA binding site
886293004798	FCD domain; Region: FCD; pfam07729
886293004799	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
886293004800	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293004801	putative substrate translocation pore; other site
886293004802	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
886293004803	Class I aldolases; Region: Aldolase_Class_I; cl17187
886293004804	catalytic residue [active]
886293004805	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
886293004806	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
886293004807	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
886293004808	oligomeric interface; other site
886293004809	putative active site [active]
886293004810	homodimer interface [polypeptide binding]; other site
886293004811	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
886293004812	dimerization interface [polypeptide binding]; other site
886293004813	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293004814	dimer interface [polypeptide binding]; other site
886293004815	phosphorylation site [posttranslational modification]
886293004816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293004817	ATP binding site [chemical binding]; other site
886293004818	G-X-G motif; other site
886293004819	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
886293004820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293004821	active site
886293004822	phosphorylation site [posttranslational modification]
886293004823	intermolecular recognition site; other site
886293004824	dimerization interface [polypeptide binding]; other site
886293004825	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
886293004826	DNA binding site [nucleotide binding]
886293004827	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293004828	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293004829	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
886293004830	Protein export membrane protein; Region: SecD_SecF; cl14618
886293004831	Uncharacterized conserved protein [Function unknown]; Region: COG3379
886293004832	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
886293004833	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
886293004834	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
886293004835	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
886293004836	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
886293004837	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
886293004838	TPR repeat; Region: TPR_11; pfam13414
886293004839	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
886293004840	Walker A motif; other site
886293004841	ATP binding site [chemical binding]; other site
886293004842	Walker B motif; other site
886293004843	arginine finger; other site
886293004844	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
886293004845	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
886293004846	active site
886293004847	Zn binding site [ion binding]; other site
886293004848	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
886293004849	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
886293004850	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
886293004851	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
886293004852	DDE domain; Region: DDE_Tnp_IS240; pfam13610
886293004853	HEAT repeats; Region: HEAT_2; pfam13646
886293004854	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
886293004855	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
886293004856	MoxR-like ATPases [General function prediction only]; Region: COG0714
886293004857	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293004858	Walker A motif; other site
886293004859	ATP binding site [chemical binding]; other site
886293004860	Walker B motif; other site
886293004861	arginine finger; other site
886293004862	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
886293004863	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
886293004864	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
886293004865	Protein of unknown function DUF58; Region: DUF58; pfam01882
886293004866	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293004867	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293004868	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293004869	DNA binding residues [nucleotide binding]
886293004870	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293004871	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293004872	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293004873	DNA binding residues [nucleotide binding]
886293004874	MoxR-like ATPases [General function prediction only]; Region: COG0714
886293004875	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293004876	Walker A motif; other site
886293004877	ATP binding site [chemical binding]; other site
886293004878	Walker B motif; other site
886293004879	arginine finger; other site
886293004880	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
886293004881	Protein of unknown function DUF58; Region: DUF58; pfam01882
886293004882	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
886293004883	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
886293004884	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
886293004885	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293004886	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
886293004887	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293004888	DNA binding residues [nucleotide binding]
886293004889	DDE superfamily endonuclease; Region: DDE_5; cl17874
886293004890	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
886293004891	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293004892	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
886293004893	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
886293004894	DDE superfamily endonuclease; Region: DDE_5; cl17874
886293004895	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
886293004896	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
886293004897	catalytic residue [active]
886293004898	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
886293004899	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
886293004900	catalytic residues [active]
886293004901	catalytic nucleophile [active]
886293004902	Recombinase; Region: Recombinase; pfam07508
886293004903	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
886293004904	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
886293004905	Homeodomain-like domain; Region: HTH_23; pfam13384
886293004906	Winged helix-turn helix; Region: HTH_29; pfam13551
886293004907	DDE superfamily endonuclease; Region: DDE_3; pfam13358
886293004908	Predicted ATPase [General function prediction only]; Region: COG5293
886293004909	Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088
886293004910	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
886293004911	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
886293004912	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
886293004913	active site
886293004914	DNA binding site [nucleotide binding]
886293004915	Int/Topo IB signature motif; other site
886293004916	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
886293004917	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
886293004918	active site
886293004919	DNA binding site [nucleotide binding]
886293004920	Int/Topo IB signature motif; other site
886293004921	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
886293004922	INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190
886293004923	Int/Topo IB signature motif; other site
886293004924	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
886293004925	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
886293004926	Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215
886293004927	DDE superfamily endonuclease; Region: DDE_5; pfam13546
886293004928	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
886293004929	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
886293004930	catalytic residues [active]
886293004931	catalytic nucleophile [active]
886293004932	Recombinase; Region: Recombinase; pfam07508
886293004933	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
886293004934	Homeodomain-like domain; Region: HTH_23; pfam13384
886293004935	Winged helix-turn helix; Region: HTH_29; pfam13551
886293004936	Homeodomain-like domain; Region: HTH_32; pfam13565
886293004937	DDE superfamily endonuclease; Region: DDE_3; pfam13358
886293004938	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
886293004939	Cation efflux family; Region: Cation_efflux; cl00316
886293004940	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
886293004941	Transposase domain (DUF772); Region: DUF772; pfam05598
886293004942	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
886293004943	transposase/IS protein; Provisional; Region: PRK09183
886293004944	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293004945	Walker A motif; other site
886293004946	ATP binding site [chemical binding]; other site
886293004947	Walker B motif; other site
886293004948	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
886293004949	Integrase core domain; Region: rve; pfam00665
886293004950	Homeodomain-like domain; Region: HTH_23; pfam13384
886293004951	Winged helix-turn helix; Region: HTH_29; pfam13551
886293004952	Homeodomain-like domain; Region: HTH_32; pfam13565
886293004953	DDE superfamily endonuclease; Region: DDE_3; pfam13358
886293004954	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
886293004955	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
886293004956	hypothetical protein; Provisional; Region: PRK14709
886293004957	D5 N terminal like; Region: D5_N; smart00885
886293004958	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
886293004959	Helix-turn-helix domain; Region: HTH_17; pfam12728
886293004960	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
886293004961	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293004962	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
886293004963	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
886293004964	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293004965	dimer interface [polypeptide binding]; other site
886293004966	phosphorylation site [posttranslational modification]
886293004967	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293004968	ATP binding site [chemical binding]; other site
886293004969	Mg2+ binding site [ion binding]; other site
886293004970	G-X-G motif; other site
886293004971	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293004972	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293004973	active site
886293004974	phosphorylation site [posttranslational modification]
886293004975	intermolecular recognition site; other site
886293004976	dimerization interface [polypeptide binding]; other site
886293004977	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293004978	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293004979	active site
886293004980	phosphorylation site [posttranslational modification]
886293004981	intermolecular recognition site; other site
886293004982	dimerization interface [polypeptide binding]; other site
886293004983	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
886293004984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293004985	active site
886293004986	phosphorylation site [posttranslational modification]
886293004987	intermolecular recognition site; other site
886293004988	dimerization interface [polypeptide binding]; other site
886293004989	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293004990	Walker A motif; other site
886293004991	ATP binding site [chemical binding]; other site
886293004992	Walker B motif; other site
886293004993	arginine finger; other site
886293004994	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
886293004995	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293004996	Major Facilitator Superfamily; Region: MFS_1; pfam07690
886293004997	putative substrate translocation pore; other site
886293004998	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
886293004999	transmembrane helices; other site
886293005000	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
886293005001	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
886293005002	active site
886293005003	Predicted acyl esterases [General function prediction only]; Region: COG2936
886293005004	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293005005	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
886293005006	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
886293005007	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293005008	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293005009	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293005010	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293005011	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293005012	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293005013	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293005014	TPR motif; other site
886293005015	binding surface
886293005016	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293005017	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
886293005018	active site
886293005019	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
886293005020	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
886293005021	classical (c) SDRs; Region: SDR_c; cd05233
886293005022	short chain dehydrogenase; Provisional; Region: PRK06181
886293005023	NAD(P) binding site [chemical binding]; other site
886293005024	active site
886293005025	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
886293005026	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
886293005027	putative acyl-acceptor binding pocket; other site
886293005028	cytidylate kinase; Provisional; Region: cmk; PRK00023
886293005029	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
886293005030	CMP-binding site; other site
886293005031	The sites determining sugar specificity; other site
886293005032	Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969
886293005033	hypothetical protein; Provisional; Region: PRK08609
886293005034	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
886293005035	active site
886293005036	primer binding site [nucleotide binding]; other site
886293005037	NTP  binding site [chemical binding]; other site
886293005038	metal binding triad [ion binding]; metal-binding site
886293005039	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
886293005040	active site
886293005041	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
886293005042	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
886293005043	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
886293005044	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293005045	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293005046	DNA binding residues [nucleotide binding]
886293005047	ribosomal protein S1; Region: rpsA; TIGR00717
886293005048	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
886293005049	RNA binding site [nucleotide binding]; other site
886293005050	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
886293005051	RNA binding site [nucleotide binding]; other site
886293005052	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
886293005053	RNA binding site [nucleotide binding]; other site
886293005054	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
886293005055	RNA binding site [nucleotide binding]; other site
886293005056	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
886293005057	RNA binding site [nucleotide binding]; other site
886293005058	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
886293005059	RNA binding site [nucleotide binding]; other site
886293005060	domain interface; other site
886293005061	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
886293005062	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
886293005063	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
886293005064	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
886293005065	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
886293005066	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
886293005067	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
886293005068	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293005069	homodimer interface [polypeptide binding]; other site
886293005070	catalytic residue [active]
886293005071	Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162
886293005072	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
886293005073	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
886293005074	putative acyl-acceptor binding pocket; other site
886293005075	acyl carrier protein; Provisional; Region: acpP; PRK00982
886293005076	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
886293005077	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
886293005078	dimer interface [polypeptide binding]; other site
886293005079	active site
886293005080	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
886293005081	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
886293005082	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
886293005083	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
886293005084	putative acyl-acceptor binding pocket; other site
886293005085	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
886293005086	active site
886293005087	ATP binding site [chemical binding]; other site
886293005088	substrate binding site [chemical binding]; other site
886293005089	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
886293005090	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
886293005091	putative active site [active]
886293005092	metal binding site [ion binding]; metal-binding site
886293005093	homodimer binding site [polypeptide binding]; other site
886293005094	phosphodiesterase; Provisional; Region: PRK12704
886293005095	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
886293005096	Zn2+ binding site [ion binding]; other site
886293005097	Mg2+ binding site [ion binding]; other site
886293005098	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
886293005099	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
886293005100	tetramer interface [polypeptide binding]; other site
886293005101	active site
886293005102	Mg2+/Mn2+ binding site [ion binding]; other site
886293005103	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
886293005104	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293005105	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293005106	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293005107	Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171
886293005108	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
886293005109	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293005110	S-adenosylmethionine binding site [chemical binding]; other site
886293005111	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
886293005112	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG1665
886293005113	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293005114	S-adenosylmethionine binding site [chemical binding]; other site
886293005115	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
886293005116	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
886293005117	Walker A/P-loop; other site
886293005118	ATP binding site [chemical binding]; other site
886293005119	Q-loop/lid; other site
886293005120	ABC transporter signature motif; other site
886293005121	Walker B; other site
886293005122	D-loop; other site
886293005123	H-loop/switch region; other site
886293005124	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
886293005125	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
886293005126	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
886293005127	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
886293005128	PYR/PP interface [polypeptide binding]; other site
886293005129	dimer interface [polypeptide binding]; other site
886293005130	TPP binding site [chemical binding]; other site
886293005131	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
886293005132	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
886293005133	TPP-binding site [chemical binding]; other site
886293005134	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
886293005135	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
886293005136	Metal-binding active site; metal-binding site
886293005137	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
886293005138	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
886293005139	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293005140	binding surface
886293005141	TPR motif; other site
886293005142	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293005143	binding surface
886293005144	TPR motif; other site
886293005145	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293005146	S-adenosylmethionine binding site [chemical binding]; other site
886293005147	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
886293005148	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
886293005149	active site
886293005150	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
886293005151	active site
886293005152	gamma-glutamyl kinase; Provisional; Region: PRK05429
886293005153	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
886293005154	nucleotide binding site [chemical binding]; other site
886293005155	homotetrameric interface [polypeptide binding]; other site
886293005156	putative phosphate binding site [ion binding]; other site
886293005157	putative allosteric binding site; other site
886293005158	PUA domain; Region: PUA; pfam01472
886293005159	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
886293005160	NADH dehydrogenase subunit B; Validated; Region: PRK06411
886293005161	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
886293005162	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
886293005163	NADH dehydrogenase subunit D; Validated; Region: PRK06075
886293005164	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
886293005165	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
886293005166	[2Fe-2S] cluster binding site [ion binding]; other site
886293005167	putative dimer interface [polypeptide binding]; other site
886293005168	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
886293005169	SLBB domain; Region: SLBB; pfam10531
886293005170	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
886293005171	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
886293005172	catalytic loop [active]
886293005173	iron binding site [ion binding]; other site
886293005174	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
886293005175	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
886293005176	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
886293005177	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
886293005178	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
886293005179	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
886293005180	4Fe-4S binding domain; Region: Fer4; pfam00037
886293005181	NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; pfam00499
886293005182	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
886293005183	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
886293005184	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
886293005185	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
886293005186	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
886293005187	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
886293005188	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
886293005189	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
886293005190	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
886293005191	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
886293005192	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
886293005193	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
886293005194	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293005195	S-adenosylmethionine binding site [chemical binding]; other site
886293005196	uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904
886293005197	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
886293005198	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
886293005199	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
886293005200	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293005201	active site
886293005202	Protein of unknown function (DUF971); Region: DUF971; pfam06155
886293005203	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293005204	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
886293005205	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
886293005206	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
886293005207	catalytic residues [active]
886293005208	catalytic nucleophile [active]
886293005209	Recombinase; Region: Recombinase; pfam07508
886293005210	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293005211	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293005212	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293005213	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
886293005214	putative active site [active]
886293005215	putative catalytic triad [active]
886293005216	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
886293005217	catalytic residues [active]
886293005218	Bacterial Ig-like domain; Region: Big_5; pfam13205
886293005219	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
886293005220	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
886293005221	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293005222	motif II; other site
886293005223	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293005224	Cytochrome c; Region: Cytochrom_C; pfam00034
886293005225	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
886293005226	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293005227	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
886293005228	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
886293005229	dimer interface [polypeptide binding]; other site
886293005230	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293005231	catalytic residue [active]
886293005232	Uncharacterized conserved protein [Function unknown]; Region: COG0432
886293005233	aldehyde dehydrogenase family 7 member; Region: PLN02315
886293005234	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
886293005235	tetrameric interface [polypeptide binding]; other site
886293005236	NAD binding site [chemical binding]; other site
886293005237	catalytic residues [active]
886293005238	hypothetical protein; Provisional; Region: PRK02227
886293005239	Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752
886293005240	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293005241	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293005242	catalytic residues [active]
886293005243	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
886293005244	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
886293005245	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
886293005246	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
886293005247	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
886293005248	active site
886293005249	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
886293005250	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
886293005251	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
886293005252	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
886293005253	putative substrate binding region [chemical binding]; other site
886293005254	Protein of unknown function (DUF433); Region: DUF433; cl01030
886293005255	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
886293005256	ABC1 family; Region: ABC1; cl17513
886293005257	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
886293005258	Peptidase family M48; Region: Peptidase_M48; cl12018
886293005259	Penicillinase repressor; Region: Pencillinase_R; pfam03965
886293005260	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
886293005261	active site
886293005262	GMP synthase; Reviewed; Region: guaA; PRK00074
886293005263	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
886293005264	AMP/PPi binding site [chemical binding]; other site
886293005265	candidate oxyanion hole; other site
886293005266	catalytic triad [active]
886293005267	potential glutamine specificity residues [chemical binding]; other site
886293005268	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
886293005269	ATP Binding subdomain [chemical binding]; other site
886293005270	Dimerization subdomain; other site
886293005271	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
886293005272	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
886293005273	active site
886293005274	metal binding site [ion binding]; metal-binding site
886293005275	pyrroline-5-carboxylate reductase; Region: PLN02688
886293005276	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
886293005277	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
886293005278	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
886293005279	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293005280	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293005281	LssY C-terminus; Region: LssY_C; pfam14067
886293005282	acetyl-CoA synthetase; Provisional; Region: PRK00174
886293005283	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
886293005284	active site
886293005285	CoA binding site [chemical binding]; other site
886293005286	acyl-activating enzyme (AAE) consensus motif; other site
886293005287	AMP binding site [chemical binding]; other site
886293005288	acetate binding site [chemical binding]; other site
886293005289	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
886293005290	putative FMN binding site [chemical binding]; other site
886293005291	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
886293005292	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
886293005293	ferrochelatase; Reviewed; Region: hemH; PRK00035
886293005294	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
886293005295	C-terminal domain interface [polypeptide binding]; other site
886293005296	active site
886293005297	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
886293005298	active site
886293005299	N-terminal domain interface [polypeptide binding]; other site
886293005300	Peptidase family M48; Region: Peptidase_M48; pfam01435
886293005301	hypothetical protein; Provisional; Region: PRK04194
886293005302	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
886293005303	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
886293005304	active site
886293005305	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293005306	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
886293005307	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
886293005308	NAD(P) binding site [chemical binding]; other site
886293005309	catalytic residues [active]
886293005310	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
886293005311	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
886293005312	minor groove reading motif; other site
886293005313	helix-hairpin-helix signature motif; other site
886293005314	substrate binding pocket [chemical binding]; other site
886293005315	active site
886293005316	heat shock protein 90; Provisional; Region: PRK05218
886293005317	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293005318	ATP binding site [chemical binding]; other site
886293005319	Mg2+ binding site [ion binding]; other site
886293005320	G-X-G motif; other site
886293005321	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
886293005322	GTP/Mg2+ binding site [chemical binding]; other site
886293005323	G2 box; other site
886293005324	Switch I region; other site
886293005325	G3 box; other site
886293005326	Switch II region; other site
886293005327	G4 box; other site
886293005328	G5 box; other site
886293005329	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
886293005330	Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258
886293005331	active site
886293005332	Zn binding site [ion binding]; other site
886293005333	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
886293005334	Metal-binding active site; metal-binding site
886293005335	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
886293005336	UMP phosphatase; Provisional; Region: PRK10444
886293005337	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293005338	active site
886293005339	motif I; other site
886293005340	motif II; other site
886293005341	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293005342	motif II; other site
886293005343	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293005344	phosphorylation site [posttranslational modification]
886293005345	dimer interface [polypeptide binding]; other site
886293005346	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293005347	ATP binding site [chemical binding]; other site
886293005348	Mg2+ binding site [ion binding]; other site
886293005349	G-X-G motif; other site
886293005350	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
886293005351	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293005352	active site
886293005353	phosphorylation site [posttranslational modification]
886293005354	intermolecular recognition site; other site
886293005355	dimerization interface [polypeptide binding]; other site
886293005356	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293005357	Walker A motif; other site
886293005358	ATP binding site [chemical binding]; other site
886293005359	Walker B motif; other site
886293005360	arginine finger; other site
886293005361	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
886293005362	methionine sulfoxide reductase B; Provisional; Region: PRK00222
886293005363	SelR domain; Region: SelR; pfam01641
886293005364	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
886293005365	Protein kinase domain; Region: Pkinase; pfam00069
886293005366	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293005367	active site
886293005368	ATP binding site [chemical binding]; other site
886293005369	substrate binding site [chemical binding]; other site
886293005370	activation loop (A-loop); other site
886293005371	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293005372	TPR repeat; Region: TPR_11; pfam13414
886293005373	binding surface
886293005374	TPR motif; other site
886293005375	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293005376	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293005377	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
886293005378	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
886293005379	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
886293005380	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
886293005381	Putative esterase; Region: Esterase; pfam00756
886293005382	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
886293005383	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
886293005384	dimer interface [polypeptide binding]; other site
886293005385	Citrate synthase; Region: Citrate_synt; pfam00285
886293005386	active site
886293005387	citrylCoA binding site [chemical binding]; other site
886293005388	NADH binding [chemical binding]; other site
886293005389	cationic pore residues; other site
886293005390	oxalacetate/citrate binding site [chemical binding]; other site
886293005391	coenzyme A binding site [chemical binding]; other site
886293005392	catalytic triad [active]
886293005393	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
886293005394	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293005395	Sulfatase; Region: Sulfatase; cl17466
886293005396	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293005397	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
886293005398	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293005399	Coenzyme A binding pocket [chemical binding]; other site
886293005400	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293005401	dimerization interface [polypeptide binding]; other site
886293005402	putative DNA binding site [nucleotide binding]; other site
886293005403	putative Zn2+ binding site [ion binding]; other site
886293005404	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
886293005405	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
886293005406	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
886293005407	NAD(P) binding site [chemical binding]; other site
886293005408	short chain dehydrogenase; Provisional; Region: PRK07677
886293005409	substrate binding site [chemical binding]; other site
886293005410	homotetramer interface [polypeptide binding]; other site
886293005411	active site
886293005412	homodimer interface [polypeptide binding]; other site
886293005413	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
886293005414	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
886293005415	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
886293005416	Cytochrome c; Region: Cytochrom_C; pfam00034
886293005417	phosphodiesterase YaeI; Provisional; Region: PRK11340
886293005418	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
886293005419	putative active site [active]
886293005420	putative metal binding site [ion binding]; other site
886293005421	Methyltransferase domain; Region: Methyltransf_31; pfam13847
886293005422	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293005423	S-adenosylmethionine binding site [chemical binding]; other site
886293005424	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
886293005425	Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797
886293005426	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
886293005427	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
886293005428	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
886293005429	PAAR motif; Region: PAAR_motif; pfam05488
886293005430	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
886293005431	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
886293005432	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
886293005433	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
886293005434	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
886293005435	Protein of unknown function (DUF796); Region: DUF796; pfam05638
886293005436	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
886293005437	Protein of unknown function (DUF877); Region: DUF877; pfam05943
886293005438	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3516
886293005439	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
886293005440	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
886293005441	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
886293005442	Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455
886293005443	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
886293005444	TPR motif; other site
886293005445	binding surface
886293005446	ImpE protein; Region: ImpE; pfam07024
886293005447	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
886293005448	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
886293005449	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
886293005450	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293005451	phosphopeptide binding site; other site
886293005452	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
886293005453	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
886293005454	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
886293005455	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522; cl01406
886293005456	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
886293005457	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
886293005458	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293005459	Walker A motif; other site
886293005460	ATP binding site [chemical binding]; other site
886293005461	Walker B motif; other site
886293005462	arginine finger; other site
886293005463	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293005464	Walker A motif; other site
886293005465	ATP binding site [chemical binding]; other site
886293005466	Walker B motif; other site
886293005467	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
886293005468	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293005469	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293005470	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
886293005471	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
886293005472	putative dimer interface [polypeptide binding]; other site
886293005473	putative anticodon binding site; other site
886293005474	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
886293005475	homodimer interface [polypeptide binding]; other site
886293005476	motif 1; other site
886293005477	motif 2; other site
886293005478	active site
886293005479	motif 3; other site
886293005480	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293005481	Coenzyme A binding pocket [chemical binding]; other site
886293005482	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
886293005483	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293005484	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293005485	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
886293005486	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293005487	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
886293005488	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
886293005489	active site
886293005490	catalytic tetrad [active]
886293005491	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
886293005492	DinB superfamily; Region: DinB_2; pfam12867
886293005493	DinB family; Region: DinB; cl17821
886293005494	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
886293005495	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
886293005496	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
886293005497	classical (c) SDRs; Region: SDR_c; cd05233
886293005498	NAD(P) binding site [chemical binding]; other site
886293005499	active site
886293005500	Uncharacterized conserved protein [Function unknown]; Region: COG3391
886293005501	Phosphoesterase family; Region: Phosphoesterase; pfam04185
886293005502	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
886293005503	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293005504	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293005505	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293005506	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293005507	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
886293005508	active site
886293005509	catalytic triad [active]
886293005510	oxyanion hole [active]
886293005511	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
886293005512	active site
886293005513	catalytic triad [active]
886293005514	oxyanion hole [active]
886293005515	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293005516	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293005517	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293005518	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293005519	Predicted acyl esterases [General function prediction only]; Region: COG2936
886293005520	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293005521	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
886293005522	Predicted esterase [General function prediction only]; Region: COG0400
886293005523	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293005524	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
886293005525	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
886293005526	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
886293005527	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293005528	Cytochrome c; Region: Cytochrom_C; pfam00034
886293005529	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
886293005530	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
886293005531	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
886293005532	Walker A/P-loop; other site
886293005533	ATP binding site [chemical binding]; other site
886293005534	Q-loop/lid; other site
886293005535	ABC transporter signature motif; other site
886293005536	Walker B; other site
886293005537	D-loop; other site
886293005538	H-loop/switch region; other site
886293005539	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
886293005540	putative carbohydrate binding site [chemical binding]; other site
886293005541	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
886293005542	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
886293005543	active site
886293005544	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
886293005545	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
886293005546	putative trimer interface [polypeptide binding]; other site
886293005547	putative CoA binding site [chemical binding]; other site
886293005548	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
886293005549	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
886293005550	inhibitor-cofactor binding pocket; inhibition site
886293005551	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293005552	catalytic residue [active]
886293005553	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293005554	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293005555	NAD(P) binding site [chemical binding]; other site
886293005556	active site
886293005557	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
886293005558	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
886293005559	inhibitor-cofactor binding pocket; inhibition site
886293005560	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293005561	catalytic residue [active]
886293005562	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
886293005563	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
886293005564	putative trimer interface [polypeptide binding]; other site
886293005565	putative active site [active]
886293005566	putative substrate binding site [chemical binding]; other site
886293005567	putative CoA binding site [chemical binding]; other site
886293005568	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293005569	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293005570	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293005571	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
886293005572	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
886293005573	Transcription antiterminator [Transcription]; Region: NusG; COG0250
886293005574	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
886293005575	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
886293005576	heterodimer interface [polypeptide binding]; other site
886293005577	homodimer interface [polypeptide binding]; other site
886293005578	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293005579	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293005580	Ubiquitin-like proteins; Region: UBQ; cl00155
886293005581	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293005582	TPR motif; other site
886293005583	binding surface
886293005584	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293005585	binding surface
886293005586	TPR motif; other site
886293005587	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
886293005588	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293005589	binding surface
886293005590	TPR motif; other site
886293005591	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293005592	TPR motif; other site
886293005593	binding surface
886293005594	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
886293005595	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
886293005596	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
886293005597	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
886293005598	Methyltransferase domain; Region: Methyltransf_31; pfam13847
886293005599	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293005600	S-adenosylmethionine binding site [chemical binding]; other site
886293005601	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
886293005602	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
886293005603	DXD motif; other site
886293005604	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293005605	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
886293005606	putative ADP-binding pocket [chemical binding]; other site
886293005607	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
886293005608	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
886293005609	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
886293005610	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
886293005611	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
886293005612	active site
886293005613	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
886293005614	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
886293005615	active site
886293005616	cosubstrate binding site; other site
886293005617	substrate binding site [chemical binding]; other site
886293005618	catalytic site [active]
886293005619	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
886293005620	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
886293005621	putative active site [active]
886293005622	putative metal binding site [ion binding]; other site
886293005623	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
886293005624	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
886293005625	active site
886293005626	dimer interface [polypeptide binding]; other site
886293005627	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
886293005628	Ligand Binding Site [chemical binding]; other site
886293005629	Molecular Tunnel; other site
886293005630	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
886293005631	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
886293005632	putative ADP-binding pocket [chemical binding]; other site
886293005633	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
886293005634	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
886293005635	dimer interface [polypeptide binding]; other site
886293005636	substrate binding site [chemical binding]; other site
886293005637	metal binding site [ion binding]; metal-binding site
886293005638	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
886293005639	FkbH-like domain; Region: FkbH; TIGR01686
886293005640	Acid Phosphatase; Region: Acid_PPase; cl17256
886293005641	putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ; Provisional; Region: PRK09677
886293005642	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
886293005643	trimer interface [polypeptide binding]; other site
886293005644	active site
886293005645	substrate binding site [chemical binding]; other site
886293005646	CoA binding site [chemical binding]; other site
886293005647	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
886293005648	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
886293005649	active site
886293005650	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293005651	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293005652	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
886293005653	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293005654	active site
886293005655	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
886293005656	Protein of unknown function (DUF3485); Region: DUF3485; cl11827
886293005657	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
886293005658	Chain length determinant protein; Region: Wzz; cl15801
886293005659	AAA domain; Region: AAA_31; pfam13614
886293005660	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
886293005661	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
886293005662	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293005663	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293005664	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293005665	DNA binding residues [nucleotide binding]
886293005666	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
886293005667	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293005668	putative substrate translocation pore; other site
886293005669	Double zinc ribbon; Region: DZR; pfam12773
886293005670	Glyco_18 domain; Region: Glyco_18; smart00636
886293005671	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
886293005672	active site
886293005673	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293005674	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293005675	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293005676	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293005677	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293005678	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
886293005679	Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316
886293005680	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
886293005681	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
886293005682	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
886293005683	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
886293005684	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
886293005685	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
886293005686	Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199
886293005687	ribosomal protein S1; Region: rpsA; TIGR00717
886293005688	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
886293005689	RNA binding site [nucleotide binding]; other site
886293005690	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
886293005691	RNA binding site [nucleotide binding]; other site
886293005692	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
886293005693	RNA binding site [nucleotide binding]; other site
886293005694	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
886293005695	RNA binding site [nucleotide binding]; other site
886293005696	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
886293005697	RNA binding site [nucleotide binding]; other site
886293005698	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
886293005699	RNA binding site [nucleotide binding]; other site
886293005700	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293005701	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293005702	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293005703	DNA binding residues [nucleotide binding]
886293005704	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
886293005705	Protein of unknown function (DUF796); Region: DUF796; pfam05638
886293005706	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293005707	DNA topoisomerase III; Provisional; Region: PRK07726
886293005708	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
886293005709	active site
886293005710	putative interdomain interaction site [polypeptide binding]; other site
886293005711	putative metal-binding site [ion binding]; other site
886293005712	putative nucleotide binding site [chemical binding]; other site
886293005713	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
886293005714	domain I; other site
886293005715	DNA binding groove [nucleotide binding]
886293005716	phosphate binding site [ion binding]; other site
886293005717	domain II; other site
886293005718	domain III; other site
886293005719	nucleotide binding site [chemical binding]; other site
886293005720	catalytic site [active]
886293005721	domain IV; other site
886293005722	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
886293005723	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
886293005724	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
886293005725	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
886293005726	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
886293005727	DNA polymerase III subunit epsilon; Validated; Region: PRK06309
886293005728	active site
886293005729	catalytic site [active]
886293005730	substrate binding site [chemical binding]; other site
886293005731	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
886293005732	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
886293005733	Indoleamine 2,3-dioxygenase; Region: IDO; pfam01231
886293005734	K+ potassium transporter; Region: K_trans; pfam02705
886293005735	Uncharacterized conserved protein [Function unknown]; Region: COG3350
886293005736	Uncharacterized conserved protein [Function unknown]; Region: COG3350
886293005737	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
886293005738	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
886293005739	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293005740	motif II; other site
886293005741	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
886293005742	putative homotetramer interface [polypeptide binding]; other site
886293005743	putative homodimer interface [polypeptide binding]; other site
886293005744	putative allosteric switch controlling residues; other site
886293005745	putative metal binding site [ion binding]; other site
886293005746	putative homodimer-homodimer interface [polypeptide binding]; other site
886293005747	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293005748	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293005749	catalytic residues [active]
886293005750	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
886293005751	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
886293005752	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
886293005753	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293005754	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293005755	Outer membrane efflux protein; Region: OEP; pfam02321
886293005756	Outer membrane efflux protein; Region: OEP; pfam02321
886293005757	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
886293005758	Ligand Binding Site [chemical binding]; other site
886293005759	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
886293005760	Ligand Binding Site [chemical binding]; other site
886293005761	Global regulator protein family; Region: CsrA; pfam02599
886293005762	BON domain; Region: BON; pfam04972
886293005763	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293005764	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
886293005765	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
886293005766	Walker A/P-loop; other site
886293005767	ATP binding site [chemical binding]; other site
886293005768	Q-loop/lid; other site
886293005769	ABC transporter signature motif; other site
886293005770	Walker B; other site
886293005771	D-loop; other site
886293005772	H-loop/switch region; other site
886293005773	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293005774	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
886293005775	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293005776	active site
886293005777	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
886293005778	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
886293005779	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
886293005780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293005781	active site
886293005782	phosphorylation site [posttranslational modification]
886293005783	intermolecular recognition site; other site
886293005784	dimerization interface [polypeptide binding]; other site
886293005785	ANTAR domain; Region: ANTAR; pfam03861
886293005786	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
886293005787	heme-binding site [chemical binding]; other site
886293005788	PAS domain S-box; Region: sensory_box; TIGR00229
886293005789	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293005790	putative active site [active]
886293005791	heme pocket [chemical binding]; other site
886293005792	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293005793	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293005794	putative active site [active]
886293005795	heme pocket [chemical binding]; other site
886293005796	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
886293005797	dimer interface [polypeptide binding]; other site
886293005798	phosphorylation site [posttranslational modification]
886293005799	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293005800	ATP binding site [chemical binding]; other site
886293005801	Mg2+ binding site [ion binding]; other site
886293005802	G-X-G motif; other site
886293005803	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
886293005804	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293005805	diaminopimelate decarboxylase; Provisional; Region: PRK11165
886293005806	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
886293005807	active site
886293005808	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
886293005809	substrate binding site [chemical binding]; other site
886293005810	catalytic residues [active]
886293005811	dimer interface [polypeptide binding]; other site
886293005812	multidrug efflux protein; Reviewed; Region: PRK09579
886293005813	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293005814	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
886293005815	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293005816	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
886293005817	Transposase domain (DUF772); Region: DUF772; pfam05598
886293005818	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
886293005819	Thioredoxin-like; Region: Thioredoxin_7; pfam13899
886293005820	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
886293005821	TROVE domain; Region: TROVE; pfam05731
886293005822	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
886293005823	metal ion-dependent adhesion site (MIDAS); other site
886293005824	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
886293005825	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
886293005826	Outer membrane efflux protein; Region: OEP; pfam02321
886293005827	Outer membrane efflux protein; Region: OEP; pfam02321
886293005828	alpha-glucosidase; Provisional; Region: PRK10137
886293005829	Global regulator protein family; Region: CsrA; pfam02599
886293005830	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
886293005831	Nitrogen regulatory protein P-II; Region: P-II; smart00938
886293005832	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293005833	sequence-specific DNA binding site [nucleotide binding]; other site
886293005834	salt bridge; other site
886293005835	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293005836	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
886293005837	phosphopeptide binding site; other site
886293005838	trigger factor; Region: tig; TIGR00115
886293005839	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
886293005840	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
886293005841	Clp protease; Region: CLP_protease; pfam00574
886293005842	oligomer interface [polypeptide binding]; other site
886293005843	active site residues [active]
886293005844	Clp protease; Region: CLP_protease; pfam00574
886293005845	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
886293005846	oligomer interface [polypeptide binding]; other site
886293005847	active site residues [active]
886293005848	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
886293005849	active site
886293005850	8-oxo-dGMP binding site [chemical binding]; other site
886293005851	nudix motif; other site
886293005852	metal binding site [ion binding]; metal-binding site
886293005853	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
886293005854	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
886293005855	NAD binding site [chemical binding]; other site
886293005856	homotetramer interface [polypeptide binding]; other site
886293005857	homodimer interface [polypeptide binding]; other site
886293005858	substrate binding site [chemical binding]; other site
886293005859	active site
886293005860	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
886293005861	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
886293005862	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
886293005863	putative active site [active]
886293005864	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
886293005865	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293005866	Cupin domain; Region: Cupin_2; pfam07883
886293005867	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
886293005868	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
886293005869	substrate binding site [chemical binding]; other site
886293005870	dimer interface [polypeptide binding]; other site
886293005871	ATP binding site [chemical binding]; other site
886293005872	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
886293005873	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
886293005874	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
886293005875	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
886293005876	nucleotide binding pocket [chemical binding]; other site
886293005877	K-X-D-G motif; other site
886293005878	catalytic site [active]
886293005879	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
886293005880	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
886293005881	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
886293005882	Dimer interface [polypeptide binding]; other site
886293005883	BRCT sequence motif; other site
886293005884	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
886293005885	active site
886293005886	multimer interface [polypeptide binding]; other site
886293005887	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
886293005888	MPN+ (JAMM) motif; other site
886293005889	Zinc-binding site [ion binding]; other site
886293005890	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
886293005891	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
886293005892	dimer interface [polypeptide binding]; other site
886293005893	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293005894	catalytic residue [active]
886293005895	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293005896	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293005897	active site
886293005898	phosphorylation site [posttranslational modification]
886293005899	intermolecular recognition site; other site
886293005900	dimerization interface [polypeptide binding]; other site
886293005901	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293005902	dimer interface [polypeptide binding]; other site
886293005903	phosphorylation site [posttranslational modification]
886293005904	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293005905	ATP binding site [chemical binding]; other site
886293005906	Mg2+ binding site [ion binding]; other site
886293005907	G-X-G motif; other site
886293005908	Chlorite dismutase; Region: Chlor_dismutase; cl01280
886293005909	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
886293005910	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
886293005911	Maf-like protein; Region: Maf; pfam02545
886293005912	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
886293005913	active site
886293005914	dimer interface [polypeptide binding]; other site
886293005915	Response regulator receiver domain; Region: Response_reg; pfam00072
886293005916	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293005917	active site
886293005918	phosphorylation site [posttranslational modification]
886293005919	intermolecular recognition site; other site
886293005920	dimerization interface [polypeptide binding]; other site
886293005921	BON domain; Region: BON; pfam04972
886293005922	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
886293005923	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
886293005924	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
886293005925	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
886293005926	homodimer interface [polypeptide binding]; other site
886293005927	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293005928	catalytic residue [active]
886293005929	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
886293005930	Isochorismatase family; Region: Isochorismatase; pfam00857
886293005931	catalytic triad [active]
886293005932	dimer interface [polypeptide binding]; other site
886293005933	conserved cis-peptide bond; other site
886293005934	PAS domain; Region: PAS; smart00091
886293005935	PAS fold; Region: PAS_4; pfam08448
886293005936	putative active site [active]
886293005937	heme pocket [chemical binding]; other site
886293005938	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
886293005939	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
886293005940	Response regulator receiver domain; Region: Response_reg; pfam00072
886293005941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293005942	active site
886293005943	phosphorylation site [posttranslational modification]
886293005944	intermolecular recognition site; other site
886293005945	dimerization interface [polypeptide binding]; other site
886293005946	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
886293005947	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
886293005948	putative active site [active]
886293005949	putative metal binding site [ion binding]; other site
886293005950	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
886293005951	von Willebrand factor type A domain; Region: VWA_2; pfam13519
886293005952	metal ion-dependent adhesion site (MIDAS); other site
886293005953	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
886293005954	Protein of unknown function DUF58; Region: DUF58; pfam01882
886293005955	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
886293005956	metal ion-dependent adhesion site (MIDAS); other site
886293005957	MoxR-like ATPases [General function prediction only]; Region: COG0714
886293005958	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293005959	Walker A motif; other site
886293005960	ATP binding site [chemical binding]; other site
886293005961	Walker B motif; other site
886293005962	arginine finger; other site
886293005963	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
886293005964	metal ion-dependent adhesion site (MIDAS); other site
886293005965	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
886293005966	von Willebrand factor type A domain; Region: VWA_2; pfam13519
886293005967	metal ion-dependent adhesion site (MIDAS); other site
886293005968	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
886293005969	FixH; Region: FixH; pfam05751
886293005970	Uncharacterized conserved protein [Function unknown]; Region: COG3391
886293005971	NHL repeat; Region: NHL; pfam01436
886293005972	NHL repeat; Region: NHL; pfam01436
886293005973	NHL repeat; Region: NHL; pfam01436
886293005974	NHL repeat; Region: NHL; pfam01436
886293005975	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
886293005976	iron-sulfur cluster [ion binding]; other site
886293005977	[2Fe-2S] cluster binding site [ion binding]; other site
886293005978	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
886293005979	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
886293005980	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
886293005981	ATP binding site [chemical binding]; other site
886293005982	substrate binding site [chemical binding]; other site
886293005983	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
886293005984	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
886293005985	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
886293005986	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
886293005987	FeS/SAM binding site; other site
886293005988	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
886293005989	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
886293005990	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
886293005991	16S/18S rRNA binding site [nucleotide binding]; other site
886293005992	S13e-L30e interaction site [polypeptide binding]; other site
886293005993	25S rRNA binding site [nucleotide binding]; other site
886293005994	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
886293005995	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
886293005996	RNase E interface [polypeptide binding]; other site
886293005997	trimer interface [polypeptide binding]; other site
886293005998	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
886293005999	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
886293006000	oligomer interface [polypeptide binding]; other site
886293006001	RNA binding site [nucleotide binding]; other site
886293006002	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
886293006003	putative nucleic acid binding region [nucleotide binding]; other site
886293006004	G-X-X-G motif; other site
886293006005	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
886293006006	RNA binding site [nucleotide binding]; other site
886293006007	domain interface; other site
886293006008	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293006009	dimer interface [polypeptide binding]; other site
886293006010	phosphorylation site [posttranslational modification]
886293006011	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293006012	ATP binding site [chemical binding]; other site
886293006013	Mg2+ binding site [ion binding]; other site
886293006014	G-X-G motif; other site
886293006015	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
886293006016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293006017	active site
886293006018	phosphorylation site [posttranslational modification]
886293006019	intermolecular recognition site; other site
886293006020	dimerization interface [polypeptide binding]; other site
886293006021	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293006022	Walker A motif; other site
886293006023	ATP binding site [chemical binding]; other site
886293006024	Walker B motif; other site
886293006025	arginine finger; other site
886293006026	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
886293006027	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
886293006028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293006029	ATP binding site [chemical binding]; other site
886293006030	Mg2+ binding site [ion binding]; other site
886293006031	G-X-G motif; other site
886293006032	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
886293006033	ATP binding site [chemical binding]; other site
886293006034	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
886293006035	bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase; Region: PLN02520
886293006036	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
886293006037	active site
886293006038	catalytic residue [active]
886293006039	dimer interface [polypeptide binding]; other site
886293006040	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
886293006041	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
886293006042	shikimate binding site; other site
886293006043	NAD(P) binding site [chemical binding]; other site
886293006044	shikimate kinase; Reviewed; Region: aroK; PRK00131
886293006045	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
886293006046	ADP binding site [chemical binding]; other site
886293006047	magnesium binding site [ion binding]; other site
886293006048	putative shikimate binding site; other site
886293006049	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
886293006050	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
886293006051	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
886293006052	rod shape-determining protein MreC; Provisional; Region: PRK13922
886293006053	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
886293006054	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
886293006055	putative active site [active]
886293006056	oxyanion strand; other site
886293006057	catalytic triad [active]
886293006058	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
886293006059	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
886293006060	catalytic residues [active]
886293006061	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
886293006062	elongation factor G; Reviewed; Region: PRK12740
886293006063	G1 box; other site
886293006064	putative GEF interaction site [polypeptide binding]; other site
886293006065	GTP/Mg2+ binding site [chemical binding]; other site
886293006066	Switch I region; other site
886293006067	G2 box; other site
886293006068	G3 box; other site
886293006069	Switch II region; other site
886293006070	G4 box; other site
886293006071	G5 box; other site
886293006072	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
886293006073	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
886293006074	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
886293006075	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
886293006076	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
886293006077	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
886293006078	substrate binding pocket [chemical binding]; other site
886293006079	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
886293006080	B12 binding site [chemical binding]; other site
886293006081	cobalt ligand [ion binding]; other site
886293006082	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
886293006083	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
886293006084	feedback inhibition sensing region; other site
886293006085	homohexameric interface [polypeptide binding]; other site
886293006086	nucleotide binding site [chemical binding]; other site
886293006087	N-acetyl-L-glutamate binding site [chemical binding]; other site
886293006088	acetylornithine aminotransferase; Provisional; Region: PRK02627
886293006089	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
886293006090	inhibitor-cofactor binding pocket; inhibition site
886293006091	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293006092	catalytic residue [active]
886293006093	ornithine carbamoyltransferase; Provisional; Region: PRK00779
886293006094	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
886293006095	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
886293006096	ribonuclease PH; Reviewed; Region: rph; PRK00173
886293006097	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
886293006098	oligomer interface [polypeptide binding]; other site
886293006099	RNA binding site [nucleotide binding]; other site
886293006100	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
886293006101	active site
886293006102	dimerization interface [polypeptide binding]; other site
886293006103	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293006104	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
886293006105	NAD(P) binding site [chemical binding]; other site
886293006106	active site
886293006107	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
886293006108	heterotetramer interface [polypeptide binding]; other site
886293006109	active site pocket [active]
886293006110	cleavage site
886293006111	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
886293006112	putative substrate binding site [chemical binding]; other site
886293006113	putative ATP binding site [chemical binding]; other site
886293006114	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
886293006115	AIR carboxylase; Region: AIRC; smart01001
886293006116	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
886293006117	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293006118	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
886293006119	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
886293006120	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
886293006121	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
886293006122	active site
886293006123	dimer interface [polypeptide binding]; other site
886293006124	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
886293006125	Ligand Binding Site [chemical binding]; other site
886293006126	Molecular Tunnel; other site
886293006127	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
886293006128	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
886293006129	active site
886293006130	metal binding site [ion binding]; metal-binding site
886293006131	homotetramer interface [polypeptide binding]; other site
886293006132	transcriptional repressor DicA; Reviewed; Region: PRK09706
886293006133	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293006134	sequence-specific DNA binding site [nucleotide binding]; other site
886293006135	salt bridge; other site
886293006136	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
886293006137	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
886293006138	substrate binding pocket [chemical binding]; other site
886293006139	chain length determination region; other site
886293006140	substrate-Mg2+ binding site; other site
886293006141	catalytic residues [active]
886293006142	aspartate-rich region 1; other site
886293006143	active site lid residues [active]
886293006144	aspartate-rich region 2; other site
886293006145	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
886293006146	trimer interface [polypeptide binding]; other site
886293006147	dimer interface [polypeptide binding]; other site
886293006148	putative active site [active]
886293006149	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
886293006150	DNA binding residues [nucleotide binding]
886293006151	Response regulator receiver domain; Region: Response_reg; pfam00072
886293006152	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293006153	active site
886293006154	phosphorylation site [posttranslational modification]
886293006155	intermolecular recognition site; other site
886293006156	dimerization interface [polypeptide binding]; other site
886293006157	Flagellar basal-body P-ring protein [Cell motility and secretion]; Region: FlgI; COG1706
886293006158	MoxR-like ATPases [General function prediction only]; Region: COG0714
886293006159	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293006160	Walker A motif; other site
886293006161	ATP binding site [chemical binding]; other site
886293006162	Walker B motif; other site
886293006163	arginine finger; other site
886293006164	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
886293006165	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
886293006166	metal ion-dependent adhesion site (MIDAS); other site
886293006167	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
886293006168	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
886293006169	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
886293006170	metal ion-dependent adhesion site (MIDAS); other site
886293006171	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
886293006172	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
886293006173	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293006174	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293006175	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
886293006176	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
886293006177	Uncharacterized conserved protein [Function unknown]; Region: COG2968
886293006178	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
886293006179	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
886293006180	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
886293006181	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
886293006182	TM-ABC transporter signature motif; other site
886293006183	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
886293006184	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
886293006185	Walker A/P-loop; other site
886293006186	ATP binding site [chemical binding]; other site
886293006187	Q-loop/lid; other site
886293006188	ABC transporter signature motif; other site
886293006189	Walker B; other site
886293006190	D-loop; other site
886293006191	H-loop/switch region; other site
886293006192	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
886293006193	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
886293006194	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
886293006195	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
886293006196	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
886293006197	putative ligand binding site [chemical binding]; other site
886293006198	short chain dehydrogenase; Validated; Region: PRK06484
886293006199	Uncharacterized conserved protein [Function unknown]; Region: COG3379
886293006200	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
886293006201	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293006202	Sulfatase; Region: Sulfatase; pfam00884
886293006203	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
886293006204	Tetratricopeptide repeat; Region: TPR_16; pfam13432
886293006205	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293006206	TPR motif; other site
886293006207	binding surface
886293006208	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293006209	binding surface
886293006210	TPR motif; other site
886293006211	TPR repeat; Region: TPR_11; pfam13414
886293006212	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293006213	binding surface
886293006214	TPR motif; other site
886293006215	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
886293006216	Tetratricopeptide repeat; Region: TPR_1; pfam00515
886293006217	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293006218	binding surface
886293006219	TPR motif; other site
886293006220	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
886293006221	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293006222	binding surface
886293006223	TPR motif; other site
886293006224	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293006225	binding surface
886293006226	TPR motif; other site
886293006227	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
886293006228	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
886293006229	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
886293006230	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
886293006231	DNA binding site [nucleotide binding]
886293006232	active site
886293006233	AlkA N-terminal domain; Region: AlkA_N; pfam06029
886293006234	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
886293006235	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
886293006236	minor groove reading motif; other site
886293006237	helix-hairpin-helix signature motif; other site
886293006238	substrate binding pocket [chemical binding]; other site
886293006239	active site
886293006240	Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859
886293006241	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
886293006242	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
886293006243	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293006244	ABC transporter signature motif; other site
886293006245	Walker B; other site
886293006246	D-loop; other site
886293006247	H-loop/switch region; other site
886293006248	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293006249	Walker A/P-loop; other site
886293006250	ATP binding site [chemical binding]; other site
886293006251	Q-loop/lid; other site
886293006252	ABC transporter signature motif; other site
886293006253	Walker B; other site
886293006254	D-loop; other site
886293006255	H-loop/switch region; other site
886293006256	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
886293006257	Calx-beta domain; Region: Calx-beta; pfam03160
886293006258	Calx-beta domain; Region: Calx-beta; pfam03160
886293006259	PilZ domain; Region: PilZ; cl01260
886293006260	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
886293006261	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
886293006262	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
886293006263	putative active site [active]
886293006264	putative metal binding site [ion binding]; other site
886293006265	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
886293006266	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
886293006267	active site
886293006268	PHP-associated; Region: PHP_C; pfam13263
886293006269	Rhomboid family; Region: Rhomboid; pfam01694
886293006270	Domain of unknown function (DUF1802); Region: DUF1802; pfam08819
886293006271	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
886293006272	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
886293006273	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
886293006274	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
886293006275	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293006276	motif II; other site
886293006277	Family description; Region: VCBS; pfam13517
886293006278	Family description; Region: VCBS; pfam13517
886293006279	Family description; Region: VCBS; pfam13517
886293006280	Family description; Region: VCBS; pfam13517
886293006281	Family description; Region: VCBS; pfam13517
886293006282	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
886293006283	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293006284	active site
886293006285	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
886293006286	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
886293006287	active site
886293006288	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293006289	Predicted amidohydrolase [General function prediction only]; Region: COG0388
886293006290	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585
886293006291	putative active site [active]
886293006292	catalytic triad [active]
886293006293	putative dimer interface [polypeptide binding]; other site
886293006294	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
886293006295	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
886293006296	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293006297	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293006298	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293006299	Uncharacterized conserved protein [Function unknown]; Region: COG1262
886293006300	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
886293006301	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
886293006302	ApbE family; Region: ApbE; pfam02424
886293006303	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322
886293006304	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322
886293006305	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
886293006306	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
886293006307	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
886293006308	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293006309	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293006310	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293006311	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293006312	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293006313	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
886293006314	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293006315	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293006316	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293006317	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293006318	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293006319	structural tetrad; other site
886293006320	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293006321	structural tetrad; other site
886293006322	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293006323	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293006324	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293006325	structural tetrad; other site
886293006326	Rrf2 family protein; Region: rrf2_super; TIGR00738
886293006327	Transcriptional regulator; Region: Rrf2; pfam02082
886293006328	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
886293006329	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
886293006330	active site residue [active]
886293006331	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
886293006332	active site residue [active]
886293006333	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
886293006334	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293006335	putative active site [active]
886293006336	heme pocket [chemical binding]; other site
886293006337	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293006338	dimer interface [polypeptide binding]; other site
886293006339	phosphorylation site [posttranslational modification]
886293006340	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293006341	ATP binding site [chemical binding]; other site
886293006342	Mg2+ binding site [ion binding]; other site
886293006343	G-X-G motif; other site
886293006344	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293006345	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293006346	active site
886293006347	phosphorylation site [posttranslational modification]
886293006348	intermolecular recognition site; other site
886293006349	dimerization interface [polypeptide binding]; other site
886293006350	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
886293006351	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
886293006352	active site
886293006353	catalytic tetrad [active]
886293006354	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293006355	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
886293006356	NAD(P) binding site [chemical binding]; other site
886293006357	active site
886293006358	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293006359	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
886293006360	NAD(P) binding site [chemical binding]; other site
886293006361	active site
886293006362	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
886293006363	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
886293006364	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293006365	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293006366	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293006367	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293006368	galactonate dehydratase; Provisional; Region: PRK14017
886293006369	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
886293006370	metal binding site [ion binding]; metal-binding site
886293006371	substrate binding pocket [chemical binding]; other site
886293006372	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
886293006373	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293006374	D-galactonate transporter; Region: 2A0114; TIGR00893
886293006375	putative substrate translocation pore; other site
886293006376	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293006377	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293006378	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293006379	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293006380	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293006381	Transcriptional regulators [Transcription]; Region: PurR; COG1609
886293006382	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
886293006383	DNA binding site [nucleotide binding]
886293006384	domain linker motif; other site
886293006385	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
886293006386	dimerization interface [polypeptide binding]; other site
886293006387	ligand binding site [chemical binding]; other site
886293006388	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293006389	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293006390	structural tetrad; other site
886293006391	NAD-dependent deacetylase; Provisional; Region: PRK00481
886293006392	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
886293006393	NAD+ binding site [chemical binding]; other site
886293006394	substrate binding site [chemical binding]; other site
886293006395	Zn binding site [ion binding]; other site
886293006396	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
886293006397	CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621
886293006398	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
886293006399	CRISPR-associated protein Csx17, subtype Dpsyc; Region: cas_csx17; TIGR04113
886293006400	CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767
886293006401	CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834
886293006402	CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827
886293006403	hypothetical protein; Validated; Region: PRK00029
886293006404	Uncharacterized conserved protein [Function unknown]; Region: COG0397
886293006405	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293006406	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293006407	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293006408	active site
886293006409	ATP binding site [chemical binding]; other site
886293006410	substrate binding site [chemical binding]; other site
886293006411	activation loop (A-loop); other site
886293006412	Tetratricopeptide repeat; Region: TPR_16; pfam13432
886293006413	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293006414	TPR motif; other site
886293006415	binding surface
886293006416	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293006417	binding surface
886293006418	TPR motif; other site
886293006419	Trehalose utilisation; Region: ThuA; pfam06283
886293006420	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293006421	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293006422	Cytochrome c; Region: Cytochrom_C; pfam00034
886293006423	N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858
886293006424	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
886293006425	Putative esterase; Region: Esterase; pfam00756
886293006426	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
886293006427	Putative esterase; Region: Esterase; pfam00756
886293006428	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293006429	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293006430	Uncharacterized conserved protein [Function unknown]; Region: COG1284
886293006431	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
886293006432	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
886293006433	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293006434	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293006435	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
886293006436	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293006437	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293006438	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
886293006439	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293006440	Haem-binding domain; Region: Haem_bd; pfam14376
886293006441	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
886293006442	Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712
886293006443	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
886293006444	HEAT repeats; Region: HEAT_2; pfam13646
886293006445	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
886293006446	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
886293006447	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
886293006448	Uncharacterized conserved protein [Function unknown]; Region: COG1262
886293006449	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293006450	Sulfatase; Region: Sulfatase; pfam00884
886293006451	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
886293006452	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
886293006453	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293006454	Sulfatase; Region: Sulfatase; pfam00884
886293006455	Laminin G domain; Region: Laminin_G_2; pfam02210
886293006456	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293006457	Sulfatase; Region: Sulfatase; pfam00884
886293006458	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
886293006459	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
886293006460	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
886293006461	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
886293006462	Walker A/P-loop; other site
886293006463	ATP binding site [chemical binding]; other site
886293006464	Q-loop/lid; other site
886293006465	ABC transporter signature motif; other site
886293006466	Walker B; other site
886293006467	D-loop; other site
886293006468	H-loop/switch region; other site
886293006469	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
886293006470	Walker A/P-loop; other site
886293006471	ATP binding site [chemical binding]; other site
886293006472	Q-loop/lid; other site
886293006473	ABC transporter signature motif; other site
886293006474	Walker B; other site
886293006475	D-loop; other site
886293006476	H-loop/switch region; other site
886293006477	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
886293006478	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
886293006479	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
886293006480	E3 interaction surface; other site
886293006481	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293006482	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
886293006483	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
886293006484	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
886293006485	putative ligand binding site [chemical binding]; other site
886293006486	putative NAD binding site [chemical binding]; other site
886293006487	catalytic site [active]
886293006488	putative phosphoketolase; Provisional; Region: PRK05261
886293006489	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
886293006490	TPP-binding site; other site
886293006491	XFP C-terminal domain; Region: XFP_C; pfam09363
886293006492	Acetokinase family; Region: Acetate_kinase; cl17229
886293006493	propionate/acetate kinase; Provisional; Region: PRK12379
886293006494	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
886293006495	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293006496	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293006497	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293006498	DNA binding residues [nucleotide binding]
886293006499	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293006500	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293006501	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
886293006502	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293006503	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
886293006504	active site
886293006505	catalytic triad [active]
886293006506	oxyanion hole [active]
886293006507	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
886293006508	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
886293006509	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
886293006510	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
886293006511	active site
886293006512	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
886293006513	Ca binding site [ion binding]; other site
886293006514	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293006515	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293006516	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293006517	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293006518	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293006519	DNA binding residues [nucleotide binding]
886293006520	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293006521	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293006522	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1; cd01653
886293006523	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
886293006524	conserved cys residue [active]
886293006525	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293006526	HEAT repeats; Region: HEAT_2; pfam13646
886293006527	HEAT repeats; Region: HEAT_2; pfam13646
886293006528	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293006529	Cytochrome c; Region: Cytochrom_C; pfam00034
886293006530	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293006531	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293006532	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
886293006533	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293006534	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293006535	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
886293006536	catalytic site [active]
886293006537	BNR repeat-like domain; Region: BNR_2; pfam13088
886293006538	Asp-box motif; other site
886293006539	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
886293006540	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
886293006541	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
886293006542	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
886293006543	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293006544	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
886293006545	DNA interaction; other site
886293006546	DDE superfamily endonuclease; Region: DDE_5; cl17874
886293006547	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293006548	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
886293006549	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293006550	NAD(P) binding site [chemical binding]; other site
886293006551	active site
886293006552	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
886293006553	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
886293006554	putative NAD(P) binding site [chemical binding]; other site
886293006555	catalytic Zn binding site [ion binding]; other site
886293006556	structural Zn binding site [ion binding]; other site
886293006557	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
886293006558	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
886293006559	active site
886293006560	catalytic tetrad [active]
886293006561	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
886293006562	active site
886293006563	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
886293006564	RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984
886293006565	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293006566	DNA binding residues [nucleotide binding]
886293006567	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293006568	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293006569	active site
886293006570	ATP binding site [chemical binding]; other site
886293006571	substrate binding site [chemical binding]; other site
886293006572	activation loop (A-loop); other site
886293006573	Trehalose utilisation; Region: ThuA; pfam06283
886293006574	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293006575	HEAT repeats; Region: HEAT_2; pfam13646
886293006576	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293006577	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
886293006578	Quinolinate synthetase A protein; Region: NadA; pfam02445
886293006579	TPR repeat; Region: TPR_11; pfam13414
886293006580	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293006581	binding surface
886293006582	TPR motif; other site
886293006583	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
886293006584	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293006585	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293006586	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293006587	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
886293006588	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
886293006589	Uncharacterized conserved protein [Function unknown]; Region: COG1359
886293006590	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
886293006591	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
886293006592	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
886293006593	IHF dimer interface [polypeptide binding]; other site
886293006594	IHF - DNA interface [nucleotide binding]; other site
886293006595	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
886293006596	putative acyl-acceptor binding pocket; other site
886293006597	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
886293006598	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
886293006599	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293006600	non-specific DNA binding site [nucleotide binding]; other site
886293006601	salt bridge; other site
886293006602	sequence-specific DNA binding site [nucleotide binding]; other site
886293006603	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
886293006604	homodimer interface [polypeptide binding]; other site
886293006605	chemical substrate binding site [chemical binding]; other site
886293006606	oligomer interface [polypeptide binding]; other site
886293006607	metal binding site [ion binding]; metal-binding site
886293006608	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
886293006609	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
886293006610	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
886293006611	catalytic site [active]
886293006612	active site
886293006613	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
886293006614	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
886293006615	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
886293006616	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
886293006617	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293006618	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293006619	active site
886293006620	ATP binding site [chemical binding]; other site
886293006621	substrate binding site [chemical binding]; other site
886293006622	activation loop (A-loop); other site
886293006623	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
886293006624	beta-galactosidase; Region: BGL; TIGR03356
886293006625	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293006626	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293006627	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293006628	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293006629	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
886293006630	phosphorylation site [posttranslational modification]
886293006631	intermolecular recognition site; other site
886293006632	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
886293006633	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
886293006634	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
886293006635	Beta-lactamase; Region: Beta-lactamase; pfam00144
886293006636	D-aminopeptidase; Reviewed; Region: PRK13128
886293006637	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
886293006638	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
886293006639	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293006640	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293006641	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293006642	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293006643	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293006644	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293006645	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293006646	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293006647	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293006648	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
886293006649	catalytic motif [active]
886293006650	Catalytic residue [active]
886293006651	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293006652	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293006653	active site
886293006654	ATP binding site [chemical binding]; other site
886293006655	substrate binding site [chemical binding]; other site
886293006656	activation loop (A-loop); other site
886293006657	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293006658	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293006659	structural tetrad; other site
886293006660	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493
886293006661	Na binding site [ion binding]; other site
886293006662	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
886293006663	Beta-lactamase; Region: Beta-lactamase; pfam00144
886293006664	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
886293006665	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
886293006666	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
886293006667	putative active site [active]
886293006668	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
886293006669	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293006670	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293006671	active site
886293006672	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293006673	active site
886293006674	Protein of unknown function (DUF1574); Region: DUF1574; pfam07611
886293006675	Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632
886293006676	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
886293006677	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293006678	Walker A motif; other site
886293006679	ATP binding site [chemical binding]; other site
886293006680	Walker B motif; other site
886293006681	arginine finger; other site
886293006682	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
886293006683	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
886293006684	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
886293006685	Deoxyhypusine synthase; Region: DS; cl00826
886293006686	deoxyhypusine synthase; Region: dhys; TIGR00321
886293006687	pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285
886293006688	Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513
886293006689	active site
886293006690	dimer interface [polypeptide binding]; other site
886293006691	catalytic nucleophile [active]
886293006692	HEAT repeats; Region: HEAT_2; pfam13646
886293006693	HEAT repeats; Region: HEAT_2; pfam13646
886293006694	MutS domain III; Region: MutS_III; pfam05192
886293006695	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
886293006696	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
886293006697	Walker A/P-loop; other site
886293006698	ATP binding site [chemical binding]; other site
886293006699	Q-loop/lid; other site
886293006700	ABC transporter signature motif; other site
886293006701	Walker B; other site
886293006702	D-loop; other site
886293006703	H-loop/switch region; other site
886293006704	glycogen branching enzyme; Provisional; Region: PRK05402
886293006705	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
886293006706	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
886293006707	active site
886293006708	catalytic site [active]
886293006709	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
886293006710	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
886293006711	putative catalytic site [active]
886293006712	putative metal binding site [ion binding]; other site
886293006713	putative phosphate binding site [ion binding]; other site
886293006714	Response regulator receiver domain; Region: Response_reg; pfam00072
886293006715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293006716	active site
886293006717	phosphorylation site [posttranslational modification]
886293006718	intermolecular recognition site; other site
886293006719	dimerization interface [polypeptide binding]; other site
886293006720	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293006721	dimer interface [polypeptide binding]; other site
886293006722	phosphorylation site [posttranslational modification]
886293006723	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293006724	ATP binding site [chemical binding]; other site
886293006725	Mg2+ binding site [ion binding]; other site
886293006726	G-X-G motif; other site
886293006727	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
886293006728	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293006729	putative active site [active]
886293006730	heme pocket [chemical binding]; other site
886293006731	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293006732	putative active site [active]
886293006733	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293006734	heme pocket [chemical binding]; other site
886293006735	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293006736	dimer interface [polypeptide binding]; other site
886293006737	phosphorylation site [posttranslational modification]
886293006738	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293006739	ATP binding site [chemical binding]; other site
886293006740	Mg2+ binding site [ion binding]; other site
886293006741	G-X-G motif; other site
886293006742	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293006743	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293006744	active site
886293006745	phosphorylation site [posttranslational modification]
886293006746	intermolecular recognition site; other site
886293006747	dimerization interface [polypeptide binding]; other site
886293006748	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293006749	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
886293006750	active site clefts [active]
886293006751	zinc binding site [ion binding]; other site
886293006752	dimer interface [polypeptide binding]; other site
886293006753	Helix-turn-helix domain; Region: HTH_17; pfam12728
886293006754	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
886293006755	active site
886293006756	phosphorylation site [posttranslational modification]
886293006757	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293006758	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
886293006759	putative ADP-binding pocket [chemical binding]; other site
886293006760	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
886293006761	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
886293006762	active site
886293006763	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
886293006764	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
886293006765	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
886293006766	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293006767	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293006768	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293006769	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293006770	catalytic residues [active]
886293006771	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293006772	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293006773	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293006774	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
886293006775	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
886293006776	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
886293006777	TAP-like protein; Region: Abhydrolase_4; pfam08386
886293006778	4-alpha-glucanotransferase; Provisional; Region: PRK14508
886293006779	FOG: CBS domain [General function prediction only]; Region: COG0517
886293006780	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
886293006781	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
886293006782	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
886293006783	oligomerization interface [polypeptide binding]; other site
886293006784	active site
886293006785	metal binding site [ion binding]; metal-binding site
886293006786	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
886293006787	aromatic arch; other site
886293006788	DCoH dimer interaction site [polypeptide binding]; other site
886293006789	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
886293006790	DCoH tetramer interaction site [polypeptide binding]; other site
886293006791	substrate binding site [chemical binding]; other site
886293006792	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
886293006793	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
886293006794	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
886293006795	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293006796	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
886293006797	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
886293006798	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
886293006799	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293006800	Walker A/P-loop; other site
886293006801	ATP binding site [chemical binding]; other site
886293006802	Q-loop/lid; other site
886293006803	ABC transporter signature motif; other site
886293006804	Walker B; other site
886293006805	D-loop; other site
886293006806	H-loop/switch region; other site
886293006807	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293006808	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293006809	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293006810	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
886293006811	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
886293006812	active site
886293006813	dimerization interface [polypeptide binding]; other site
886293006814	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
886293006815	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
886293006816	dimer interface [polypeptide binding]; other site
886293006817	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
886293006818	active site
886293006819	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
886293006820	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
886293006821	nucleotide binding site [chemical binding]; other site
886293006822	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
886293006823	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
886293006824	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
886293006825	active site
886293006826	catalytic site [active]
886293006827	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
886293006828	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
886293006829	active site
886293006830	metal binding site [ion binding]; metal-binding site
886293006831	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
886293006832	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293006833	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
886293006834	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
886293006835	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
886293006836	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293006837	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
886293006838	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
886293006839	asparagine synthetase-like protein; Provisional; Region: PTZ00077
886293006840	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293006841	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293006842	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
886293006843	DNA binding residues [nucleotide binding]
886293006844	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
886293006845	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
886293006846	DNA binding residues [nucleotide binding]
886293006847	dimer interface [polypeptide binding]; other site
886293006848	[2Fe-2S] cluster binding site [ion binding]; other site
886293006849	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293006850	NADH(P)-binding; Region: NAD_binding_10; pfam13460
886293006851	NAD(P) binding site [chemical binding]; other site
886293006852	active site
886293006853	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
886293006854	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
886293006855	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
886293006856	putative active site [active]
886293006857	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
886293006858	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
886293006859	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
886293006860	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
886293006861	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293006862	S-adenosylmethionine binding site [chemical binding]; other site
886293006863	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
886293006864	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
886293006865	putative metal binding site; other site
886293006866	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
886293006867	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
886293006868	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
886293006869	Probable Catalytic site; other site
886293006870	metal-binding site
886293006871	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293006872	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
886293006873	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
886293006874	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
886293006875	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
886293006876	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
886293006877	FeS/SAM binding site; other site
886293006878	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
886293006879	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
886293006880	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
886293006881	Active site cavity [active]
886293006882	catalytic acid [active]
886293006883	BON domain; Region: BON; pfam04972
886293006884	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
886293006885	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
886293006886	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
886293006887	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293006888	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
886293006889	Cytochrome c; Region: Cytochrom_C; pfam00034
886293006890	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
886293006891	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
886293006892	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
886293006893	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
886293006894	dimer interface [polypeptide binding]; other site
886293006895	active site
886293006896	CoA binding pocket [chemical binding]; other site
886293006897	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
886293006898	anti sigma factor interaction site; other site
886293006899	regulatory phosphorylation site [posttranslational modification]; other site
886293006900	Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
886293006901	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
886293006902	nucleotide binding site [chemical binding]; other site
886293006903	putative NEF/HSP70 interaction site [polypeptide binding]; other site
886293006904	SBD interface [polypeptide binding]; other site
886293006905	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
886293006906	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
886293006907	FAD binding domain; Region: FAD_binding_4; pfam01565
886293006908	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
886293006909	Cysteine-rich domain; Region: CCG; pfam02754
886293006910	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
886293006911	homodecamer interface [polypeptide binding]; other site
886293006912	GTP cyclohydrolase I; Provisional; Region: PLN03044
886293006913	active site
886293006914	putative catalytic site residues [active]
886293006915	zinc binding site [ion binding]; other site
886293006916	GTP-CH-I/GFRP interaction surface; other site
886293006917	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
886293006918	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
886293006919	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
886293006920	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293006921	putative substrate translocation pore; other site
886293006922	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293006923	HlyD family secretion protein; Region: HlyD; pfam00529
886293006924	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
886293006925	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
886293006926	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293006927	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
886293006928	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
886293006929	minor groove reading motif; other site
886293006930	helix-hairpin-helix signature motif; other site
886293006931	substrate binding pocket [chemical binding]; other site
886293006932	active site
886293006933	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
886293006934	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
886293006935	FAD binding site [chemical binding]; other site
886293006936	epoxyqueuosine reductase; Region: TIGR00276
886293006937	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
886293006938	HEAT repeats; Region: HEAT_2; pfam13646
886293006939	EF-hand domain pair; Region: EF_hand_5; pfam13499
886293006940	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
886293006941	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
886293006942	Fatty acid desaturase; Region: FA_desaturase; pfam00487
886293006943	Di-iron ligands [ion binding]; other site
886293006944	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242
886293006945	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
886293006946	putative NAD(P) binding site [chemical binding]; other site
886293006947	catalytic Zn binding site [ion binding]; other site
886293006948	structural Zn binding site [ion binding]; other site
886293006949	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
886293006950	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293006951	ATP binding site [chemical binding]; other site
886293006952	Mg2+ binding site [ion binding]; other site
886293006953	G-X-G motif; other site
886293006954	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
886293006955	anchoring element; other site
886293006956	dimer interface [polypeptide binding]; other site
886293006957	ATP binding site [chemical binding]; other site
886293006958	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
886293006959	active site
886293006960	metal binding site [ion binding]; metal-binding site
886293006961	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
886293006962	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
886293006963	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
886293006964	CAP-like domain; other site
886293006965	active site
886293006966	primary dimer interface [polypeptide binding]; other site
886293006967	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
886293006968	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293006969	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
886293006970	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
886293006971	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
886293006972	homodimer interface [polypeptide binding]; other site
886293006973	NADP binding site [chemical binding]; other site
886293006974	substrate binding site [chemical binding]; other site
886293006975	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
886293006976	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
886293006977	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
886293006978	anti sigma factor interaction site; other site
886293006979	regulatory phosphorylation site [posttranslational modification]; other site
886293006980	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
886293006981	anti sigma factor interaction site; other site
886293006982	regulatory phosphorylation site [posttranslational modification]; other site
886293006983	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293006984	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
886293006985	putative homodimer interface [polypeptide binding]; other site
886293006986	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
886293006987	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293006988	putative substrate translocation pore; other site
886293006989	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
886293006990	dimer interface [polypeptide binding]; other site
886293006991	conserved gate region; other site
886293006992	putative PBP binding loops; other site
886293006993	ABC-ATPase subunit interface; other site
886293006994	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
886293006995	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
886293006996	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293006997	Walker A/P-loop; other site
886293006998	ATP binding site [chemical binding]; other site
886293006999	Q-loop/lid; other site
886293007000	ABC transporter signature motif; other site
886293007001	Walker B; other site
886293007002	D-loop; other site
886293007003	H-loop/switch region; other site
886293007004	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
886293007005	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293007006	non-specific DNA binding site [nucleotide binding]; other site
886293007007	salt bridge; other site
886293007008	sequence-specific DNA binding site [nucleotide binding]; other site
886293007009	hypothetical protein; Provisional; Region: PRK09256
886293007010	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
886293007011	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
886293007012	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
886293007013	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293007014	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
886293007015	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
886293007016	Walker A/P-loop; other site
886293007017	ATP binding site [chemical binding]; other site
886293007018	Q-loop/lid; other site
886293007019	ABC transporter signature motif; other site
886293007020	Walker B; other site
886293007021	D-loop; other site
886293007022	H-loop/switch region; other site
886293007023	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
886293007024	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
886293007025	FtsX-like permease family; Region: FtsX; pfam02687
886293007026	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
886293007027	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
886293007028	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
886293007029	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
886293007030	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
886293007031	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
886293007032	active site
886293007033	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
886293007034	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
886293007035	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
886293007036	dihydroorotase; Validated; Region: pyrC; PRK09357
886293007037	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293007038	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
886293007039	active site
886293007040	YacP-like NYN domain; Region: NYN_YacP; cl01491
886293007041	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
886293007042	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
886293007043	CoA-ligase; Region: Ligase_CoA; pfam00549
886293007044	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
886293007045	CoA binding domain; Region: CoA_binding; smart00881
886293007046	CoA-ligase; Region: Ligase_CoA; pfam00549
886293007047	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
886293007048	dimer interface [polypeptide binding]; other site
886293007049	ADP-ribose binding site [chemical binding]; other site
886293007050	active site
886293007051	nudix motif; other site
886293007052	metal binding site [ion binding]; metal-binding site
886293007053	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
886293007054	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293007055	NAD(P) binding site [chemical binding]; other site
886293007056	active site
886293007057	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
886293007058	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
886293007059	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293007060	S-adenosylmethionine binding site [chemical binding]; other site
886293007061	Helix-turn-helix domain; Region: HTH_28; pfam13518
886293007062	Winged helix-turn helix; Region: HTH_29; pfam13551
886293007063	Homeodomain-like domain; Region: HTH_32; pfam13565
886293007064	DDE superfamily endonuclease; Region: DDE_3; pfam13358
886293007065	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
886293007066	amidase catalytic site [active]
886293007067	Zn binding residues [ion binding]; other site
886293007068	substrate binding site [chemical binding]; other site
886293007069	aminoacyl-tRNA ligase; Region: PLN02563
886293007070	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
886293007071	HIGH motif; other site
886293007072	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
886293007073	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
886293007074	active site
886293007075	KMSKS motif; other site
886293007076	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
886293007077	tRNA binding surface [nucleotide binding]; other site
886293007078	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
886293007079	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
886293007080	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
886293007081	nucleotide binding site [chemical binding]; other site
886293007082	putative NEF/HSP70 interaction site [polypeptide binding]; other site
886293007083	SBD interface [polypeptide binding]; other site
886293007084	DNA-K related protein; Region: DUF3731; pfam12531
886293007085	MULE transposase domain; Region: MULE; pfam10551
886293007086	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
886293007087	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293007088	NHL repeat; Region: NHL; pfam01436
886293007089	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
886293007090	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
886293007091	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
886293007092	active site
886293007093	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
886293007094	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
886293007095	metal ion-dependent adhesion site (MIDAS); other site
886293007096	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
886293007097	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
886293007098	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
886293007099	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
886293007100	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
886293007101	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
886293007102	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
886293007103	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
886293007104	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293007105	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
886293007106	putative ADP-binding pocket [chemical binding]; other site
886293007107	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
886293007108	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
886293007109	dimerization interface 3.5A [polypeptide binding]; other site
886293007110	active site
886293007111	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
886293007112	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
886293007113	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
886293007114	ATP-grasp domain; Region: ATP-grasp_4; cl17255
886293007115	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
886293007116	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
886293007117	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293007118	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
886293007119	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
886293007120	LicD family; Region: LicD; pfam04991
886293007121	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323
886293007122	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293007123	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
886293007124	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
886293007125	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
886293007126	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
886293007127	Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919
886293007128	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
886293007129	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293007130	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293007131	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293007132	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
886293007133	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
886293007134	ring oligomerisation interface [polypeptide binding]; other site
886293007135	ATP/Mg binding site [chemical binding]; other site
886293007136	stacking interactions; other site
886293007137	hinge regions; other site
886293007138	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
886293007139	oligomerisation interface [polypeptide binding]; other site
886293007140	mobile loop; other site
886293007141	roof hairpin; other site
886293007142	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
886293007143	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
886293007144	ring oligomerisation interface [polypeptide binding]; other site
886293007145	ATP/Mg binding site [chemical binding]; other site
886293007146	stacking interactions; other site
886293007147	hinge regions; other site
886293007148	chaperone protein DnaJ; Provisional; Region: PRK10767
886293007149	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
886293007150	HSP70 interaction site [polypeptide binding]; other site
886293007151	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
886293007152	substrate binding site [polypeptide binding]; other site
886293007153	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
886293007154	Zn binding sites [ion binding]; other site
886293007155	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
886293007156	dimer interface [polypeptide binding]; other site
886293007157	GrpE; Region: GrpE; pfam01025
886293007158	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
886293007159	dimer interface [polypeptide binding]; other site
886293007160	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
886293007161	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
886293007162	Domain of unknown function (DUF329); Region: DUF329; cl01144
886293007163	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
886293007164	active site
886293007165	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
886293007166	catalytic tetrad [active]
886293007167	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
886293007168	Outer membrane efflux protein; Region: OEP; pfam02321
886293007169	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
886293007170	isocitrate dehydrogenase; Validated; Region: PRK06451
886293007171	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
886293007172	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
886293007173	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
886293007174	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
886293007175	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
886293007176	putative active site [active]
886293007177	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293007178	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293007179	NAD(P) binding site [chemical binding]; other site
886293007180	active site
886293007181	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
886293007182	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
886293007183	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293007184	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293007185	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
886293007186	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293007187	active site
886293007188	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
886293007189	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293007190	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
886293007191	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
886293007192	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
886293007193	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
886293007194	DNA interaction; other site
886293007195	VanZ like family; Region: VanZ; cl01971
886293007196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
886293007197	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
886293007198	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
886293007199	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293007200	putative DNA binding site [nucleotide binding]; other site
886293007201	Predicted transcriptional regulator [Transcription]; Region: COG2345
886293007202	putative Zn2+ binding site [ion binding]; other site
886293007203	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
886293007204	putative hydrophobic ligand binding site [chemical binding]; other site
886293007205	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
886293007206	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
886293007207	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293007208	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293007209	active site
886293007210	ATP binding site [chemical binding]; other site
886293007211	substrate binding site [chemical binding]; other site
886293007212	activation loop (A-loop); other site
886293007213	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293007214	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293007215	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293007216	structural tetrad; other site
886293007217	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293007218	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293007219	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293007220	Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374
886293007221	HEAT repeats; Region: HEAT_2; pfam13646
886293007222	Cytochrome c; Region: Cytochrom_C; cl11414
886293007223	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293007224	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293007225	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
886293007226	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
886293007227	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
886293007228	HNH endonuclease; Region: HNH_3; pfam13392
886293007229	putative transcriptional regulator; Provisional; Region: tfx; cl17550
886293007230	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
886293007231	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293007232	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
886293007233	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
886293007234	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
886293007235	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293007236	Prenyltransferase-like; Region: Prenyltrans_1; pfam13243
886293007237	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
886293007238	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293007239	MoxR-like ATPases [General function prediction only]; Region: COG0714
886293007240	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293007241	Walker A motif; other site
886293007242	ATP binding site [chemical binding]; other site
886293007243	Walker B motif; other site
886293007244	arginine finger; other site
886293007245	Sodium Bile acid symporter family; Region: SBF; cl17470
886293007246	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
886293007247	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
886293007248	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293007249	homodimer interface [polypeptide binding]; other site
886293007250	catalytic residue [active]
886293007251	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
886293007252	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293007253	Walker A motif; other site
886293007254	ATP binding site [chemical binding]; other site
886293007255	Walker B motif; other site
886293007256	arginine finger; other site
886293007257	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
886293007258	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
886293007259	active site
886293007260	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
886293007261	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
886293007262	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
886293007263	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
886293007264	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
886293007265	putative catalytic site [active]
886293007266	putative metal binding site [ion binding]; other site
886293007267	putative phosphate binding site [ion binding]; other site
886293007268	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293007269	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293007270	active site
886293007271	ATP binding site [chemical binding]; other site
886293007272	substrate binding site [chemical binding]; other site
886293007273	activation loop (A-loop); other site
886293007274	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293007275	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293007276	structural tetrad; other site
886293007277	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293007278	structural tetrad; other site
886293007279	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293007280	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293007281	structural tetrad; other site
886293007282	CHAD domain; Region: CHAD; pfam05235
886293007283	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293007284	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293007285	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293007286	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293007287	Mitochondrial K+-H+ exchange-related; Region: Mit_KHE1; pfam10173
886293007288	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
886293007289	putative acyl-acceptor binding pocket; other site
886293007290	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
886293007291	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
886293007292	active site
886293007293	catalytic motif [active]
886293007294	Zn binding site [ion binding]; other site
886293007295	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
886293007296	conserved cys residue [active]
886293007297	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
886293007298	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293007299	putative catalytic residue [active]
886293007300	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293007301	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293007302	catalytic residues [active]
886293007303	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
886293007304	peptide chain release factor 1; Validated; Region: prfA; PRK00591
886293007305	PCRF domain; Region: PCRF; pfam03462
886293007306	RF-1 domain; Region: RF-1; pfam00472
886293007307	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
886293007308	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293007309	S-adenosylmethionine binding site [chemical binding]; other site
886293007310	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293007311	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293007312	active site
886293007313	ATP binding site [chemical binding]; other site
886293007314	substrate binding site [chemical binding]; other site
886293007315	activation loop (A-loop); other site
886293007316	Putative phosphatase (DUF442); Region: DUF442; cl17385
886293007317	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
886293007318	metal ion-dependent adhesion site (MIDAS); other site
886293007319	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
886293007320	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
886293007321	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
886293007322	ligand binding site [chemical binding]; other site
886293007323	NAD binding site [chemical binding]; other site
886293007324	dimerization interface [polypeptide binding]; other site
886293007325	catalytic site [active]
886293007326	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
886293007327	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
886293007328	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
886293007329	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
886293007330	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
886293007331	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
886293007332	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293007333	DDE superfamily endonuclease; Region: DDE_5; cl17874
886293007334	FecR protein; Region: FecR; pfam04773
886293007335	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
886293007336	RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989
886293007337	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293007338	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
886293007339	DNA binding residues [nucleotide binding]
886293007340	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293007341	DDE superfamily endonuclease; Region: DDE_5; cl17874
886293007342	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293007343	Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112
886293007344	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
886293007345	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
886293007346	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293007347	Sulfatase; Region: Sulfatase; cl17466
886293007348	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
886293007349	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
886293007350	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
886293007351	putative ADP-binding pocket [chemical binding]; other site
886293007352	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
886293007353	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
886293007354	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
886293007355	RNA/DNA hybrid binding site [nucleotide binding]; other site
886293007356	active site
886293007357	Ribosomal protein S27; Region: Ribosomal_S27e; cl00897
886293007358	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
886293007359	active site
886293007360	DNA polymerase IV; Validated; Region: PRK02406
886293007361	DNA binding site [nucleotide binding]
886293007362	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
886293007363	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
886293007364	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293007365	active site
886293007366	phosphorylation site [posttranslational modification]
886293007367	intermolecular recognition site; other site
886293007368	dimerization interface [polypeptide binding]; other site
886293007369	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293007370	Walker A motif; other site
886293007371	ATP binding site [chemical binding]; other site
886293007372	Walker B motif; other site
886293007373	arginine finger; other site
886293007374	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
886293007375	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293007376	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
886293007377	dimerization interface [polypeptide binding]; other site
886293007378	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293007379	phosphorylation site [posttranslational modification]
886293007380	dimer interface [polypeptide binding]; other site
886293007381	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293007382	ATP binding site [chemical binding]; other site
886293007383	Mg2+ binding site [ion binding]; other site
886293007384	G-X-G motif; other site
886293007385	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
886293007386	Protein of unknown function (DUF1326); Region: DUF1326; cl02375
886293007387	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
886293007388	ligand binding site [chemical binding]; other site
886293007389	Helix-turn-helix domain; Region: HTH_17; pfam12728
886293007390	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
886293007391	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293007392	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293007393	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
886293007394	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
886293007395	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
886293007396	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
886293007397	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
886293007398	MraW methylase family; Region: Methyltransf_5; cl17771
886293007399	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
886293007400	Protein of unknown function (DUF1637); Region: DUF1637; pfam07847
886293007401	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293007402	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293007403	active site
886293007404	ATP binding site [chemical binding]; other site
886293007405	substrate binding site [chemical binding]; other site
886293007406	activation loop (A-loop); other site
886293007407	LexA repressor; Validated; Region: PRK00215
886293007408	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
886293007409	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
886293007410	Catalytic site [active]
886293007411	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
886293007412	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
886293007413	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
886293007414	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
886293007415	catalytic core [active]
886293007416	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
886293007417	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
886293007418	substrate binding site [chemical binding]; other site
886293007419	hexamer interface [polypeptide binding]; other site
886293007420	metal binding site [ion binding]; metal-binding site
886293007421	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
886293007422	Phosphoglycerate kinase; Region: PGK; pfam00162
886293007423	substrate binding site [chemical binding]; other site
886293007424	hinge regions; other site
886293007425	ADP binding site [chemical binding]; other site
886293007426	catalytic site [active]
886293007427	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
886293007428	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
886293007429	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
886293007430	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
886293007431	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293007432	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
886293007433	phosphopeptide binding site; other site
886293007434	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293007435	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
886293007436	phosphopeptide binding site; other site
886293007437	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
886293007438	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
886293007439	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
886293007440	putative NADP binding site [chemical binding]; other site
886293007441	putative substrate binding site [chemical binding]; other site
886293007442	active site
886293007443	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
886293007444	galactarate dehydratase; Region: galactar-dH20; TIGR03248
886293007445	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
886293007446	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293007447	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293007448	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293007449	active site
886293007450	ATP binding site [chemical binding]; other site
886293007451	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293007452	substrate binding site [chemical binding]; other site
886293007453	activation loop (A-loop); other site
886293007454	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
886293007455	Beta-lactamase; Region: Beta-lactamase; pfam00144
886293007456	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
886293007457	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293007458	HEAT repeats; Region: HEAT_2; pfam13646
886293007459	Cytochrome c; Region: Cytochrom_C; cl11414
886293007460	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293007461	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
886293007462	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293007463	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
886293007464	putative dimerization interface [polypeptide binding]; other site
886293007465	putative ligand binding site [chemical binding]; other site
886293007466	Transcriptional regulators [Transcription]; Region: PurR; COG1609
886293007467	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
886293007468	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293007469	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
886293007470	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
886293007471	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
886293007472	N- and C-terminal domain interface [polypeptide binding]; other site
886293007473	active site
886293007474	MgATP binding site [chemical binding]; other site
886293007475	catalytic site [active]
886293007476	metal binding site [ion binding]; metal-binding site
886293007477	glycerol binding site [chemical binding]; other site
886293007478	homotetramer interface [polypeptide binding]; other site
886293007479	homodimer interface [polypeptide binding]; other site
886293007480	FBP binding site [chemical binding]; other site
886293007481	protein IIAGlc interface [polypeptide binding]; other site
886293007482	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620
886293007483	putative ligand binding site [chemical binding]; other site
886293007484	Protein kinase domain; Region: Pkinase; pfam00069
886293007485	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293007486	active site
886293007487	ATP binding site [chemical binding]; other site
886293007488	substrate binding site [chemical binding]; other site
886293007489	activation loop (A-loop); other site
886293007490	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293007491	TPR motif; other site
886293007492	TPR repeat; Region: TPR_11; pfam13414
886293007493	binding surface
886293007494	TPR repeat; Region: TPR_11; pfam13414
886293007495	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293007496	binding surface
886293007497	TPR motif; other site
886293007498	PSP1 C-terminal conserved region; Region: PSP1; cl00770
886293007499	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
886293007500	Heavy-metal-associated domain; Region: HMA; pfam00403
886293007501	metal-binding site [ion binding]
886293007502	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
886293007503	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
886293007504	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
886293007505	active site
886293007506	catalytic residues [active]
886293007507	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
886293007508	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
886293007509	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
886293007510	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
886293007511	active site
886293007512	dimer interface [polypeptide binding]; other site
886293007513	effector binding site; other site
886293007514	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
886293007515	TSCPD domain; Region: TSCPD; pfam12637
886293007516	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293007517	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293007518	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293007519	DNA binding residues [nucleotide binding]
886293007520	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
886293007521	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
886293007522	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
886293007523	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
886293007524	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
886293007525	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
886293007526	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
886293007527	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
886293007528	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
886293007529	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
886293007530	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
886293007531	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
886293007532	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
886293007533	dimerization domain swap beta strand [polypeptide binding]; other site
886293007534	regulatory protein interface [polypeptide binding]; other site
886293007535	active site
886293007536	regulatory phosphorylation site [posttranslational modification]; other site
886293007537	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
886293007538	active site
886293007539	phosphorylation site [posttranslational modification]
886293007540	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
886293007541	30S subunit binding site; other site
886293007542	L-lactate permease; Region: Lactate_perm; cl00701
886293007543	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
886293007544	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
886293007545	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
886293007546	active site
886293007547	metal binding site [ion binding]; metal-binding site
886293007548	homotetramer interface [polypeptide binding]; other site
886293007549	Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562
886293007550	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
886293007551	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
886293007552	putative trimer interface [polypeptide binding]; other site
886293007553	putative CoA binding site [chemical binding]; other site
886293007554	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
886293007555	EamA-like transporter family; Region: EamA; pfam00892
886293007556	Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171
886293007557	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
886293007558	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
886293007559	NAD binding site [chemical binding]; other site
886293007560	ligand binding site [chemical binding]; other site
886293007561	catalytic site [active]
886293007562	Peptidase family M48; Region: Peptidase_M48; cl12018
886293007563	Penicillinase repressor; Region: Pencillinase_R; cl17580
886293007564	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
886293007565	Creatinine amidohydrolase; Region: Creatininase; pfam02633
886293007566	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
886293007567	MgtE intracellular N domain; Region: MgtE_N; pfam03448
886293007568	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
886293007569	Divalent cation transporter; Region: MgtE; pfam01769
886293007570	seryl-tRNA synthetase; Provisional; Region: PRK05431
886293007571	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
886293007572	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
886293007573	dimer interface [polypeptide binding]; other site
886293007574	active site
886293007575	motif 1; other site
886293007576	motif 2; other site
886293007577	motif 3; other site
886293007578	hypothetical protein; Provisional; Region: PRK08201
886293007579	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
886293007580	metal binding site [ion binding]; metal-binding site
886293007581	putative dimer interface [polypeptide binding]; other site
886293007582	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
886293007583	VanZ like family; Region: VanZ; cl01971
886293007584	Family description; Region: VCBS; pfam13517
886293007585	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
886293007586	putative active site [active]
886293007587	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293007588	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293007589	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293007590	DNA binding residues [nucleotide binding]
886293007591	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
886293007592	putative active site [active]
886293007593	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
886293007594	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
886293007595	inhibitor-cofactor binding pocket; inhibition site
886293007596	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293007597	catalytic residue [active]
886293007598	A/G-specific adenine glycosylase; Region: mutY; TIGR01084
886293007599	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
886293007600	minor groove reading motif; other site
886293007601	helix-hairpin-helix signature motif; other site
886293007602	substrate binding pocket [chemical binding]; other site
886293007603	active site
886293007604	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
886293007605	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
886293007606	nudix motif; other site
886293007607	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
886293007608	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
886293007609	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293007610	Walker A motif; other site
886293007611	ATP binding site [chemical binding]; other site
886293007612	Walker B motif; other site
886293007613	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
886293007614	aspartate aminotransferase; Provisional; Region: PRK05764
886293007615	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
886293007616	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293007617	homodimer interface [polypeptide binding]; other site
886293007618	catalytic residue [active]
886293007619	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293007620	Major Facilitator Superfamily; Region: MFS_1; pfam07690
886293007621	putative substrate translocation pore; other site
886293007622	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
886293007623	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
886293007624	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
886293007625	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293007626	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
886293007627	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
886293007628	Walker A/P-loop; other site
886293007629	ATP binding site [chemical binding]; other site
886293007630	Q-loop/lid; other site
886293007631	ABC transporter signature motif; other site
886293007632	Walker B; other site
886293007633	D-loop; other site
886293007634	H-loop/switch region; other site
886293007635	TOBE domain; Region: TOBE_2; pfam08402
886293007636	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
886293007637	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
886293007638	XdhC Rossmann domain; Region: XdhC_C; pfam13478
886293007639	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
886293007640	Ligand binding site; other site
886293007641	metal-binding site
886293007642	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
886293007643	MoaE interaction surface [polypeptide binding]; other site
886293007644	MoeB interaction surface [polypeptide binding]; other site
886293007645	thiocarboxylated glycine; other site
886293007646	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
886293007647	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293007648	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293007649	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293007650	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
886293007651	EF-hand domain pair; Region: EF_hand_5; pfam13499
886293007652	Ca2+ binding site [ion binding]; other site
886293007653	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
886293007654	Ca2+ binding site [ion binding]; other site
886293007655	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
886293007656	Ca2+ binding site [ion binding]; other site
886293007657	EF-hand domain pair; Region: EF_hand_5; pfam13499
886293007658	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
886293007659	Ca2+ binding site [ion binding]; other site
886293007660	EF-hand domain pair; Region: EF_hand_5; pfam13499
886293007661	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
886293007662	Ca2+ binding site [ion binding]; other site
886293007663	hypothetical protein; Reviewed; Region: PRK12497
886293007664	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293007665	putative substrate translocation pore; other site
886293007666	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293007667	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
886293007668	active site
886293007669	catalytic triad [active]
886293007670	oxyanion hole [active]
886293007671	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
886293007672	active site
886293007673	catalytic residues [active]
886293007674	Predicted transcriptional regulators [Transcription]; Region: COG1725
886293007675	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
886293007676	DNA-binding site [nucleotide binding]; DNA binding site
886293007677	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
886293007678	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
886293007679	Walker A/P-loop; other site
886293007680	ATP binding site [chemical binding]; other site
886293007681	Q-loop/lid; other site
886293007682	ABC transporter signature motif; other site
886293007683	Walker B; other site
886293007684	D-loop; other site
886293007685	H-loop/switch region; other site
886293007686	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
886293007687	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
886293007688	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
886293007689	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293007690	putative hydrolase; Provisional; Region: PRK10985
886293007691	NHL repeat; Region: NHL; pfam01436
886293007692	NHL repeat; Region: NHL; pfam01436
886293007693	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
886293007694	Ferritin-like domain; Region: Ferritin; pfam00210
886293007695	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
886293007696	dinuclear metal binding motif [ion binding]; other site
886293007697	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238
886293007698	dimer interface [polypeptide binding]; other site
886293007699	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
886293007700	Methyltransferase domain; Region: Methyltransf_23; pfam13489
886293007701	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293007702	S-adenosylmethionine binding site [chemical binding]; other site
886293007703	Transposase domain (DUF772); Region: DUF772; pfam05598
886293007704	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
886293007705	Homeodomain-like domain; Region: HTH_23; pfam13384
886293007706	Winged helix-turn helix; Region: HTH_29; pfam13551
886293007707	DDE superfamily endonuclease; Region: DDE_3; pfam13358
886293007708	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293007709	fumarate hydratase; Provisional; Region: PRK15389
886293007710	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
886293007711	Fumarase C-terminus; Region: Fumerase_C; pfam05683
886293007712	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
886293007713	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
886293007714	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
886293007715	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293007716	Walker A motif; other site
886293007717	ATP binding site [chemical binding]; other site
886293007718	Walker B motif; other site
886293007719	arginine finger; other site
886293007720	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
886293007721	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
886293007722	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
886293007723	putative substrate binding site [chemical binding]; other site
886293007724	putative ATP binding site [chemical binding]; other site
886293007725	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
886293007726	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
886293007727	Sulfate transporter family; Region: Sulfate_transp; pfam00916
886293007728	Sulfate transporter family; Region: Sulfate_transp; pfam00916
886293007729	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
886293007730	active site clefts [active]
886293007731	zinc binding site [ion binding]; other site
886293007732	dimer interface [polypeptide binding]; other site
886293007733	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
886293007734	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
886293007735	PYR/PP interface [polypeptide binding]; other site
886293007736	dimer interface [polypeptide binding]; other site
886293007737	TPP binding site [chemical binding]; other site
886293007738	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
886293007739	transketolase; Reviewed; Region: PRK05899
886293007740	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
886293007741	TPP-binding site [chemical binding]; other site
886293007742	dimer interface [polypeptide binding]; other site
886293007743	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
886293007744	Fe-S cluster binding site [ion binding]; other site
886293007745	active site
886293007746	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
886293007747	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
886293007748	HEAT repeats; Region: HEAT_2; pfam13646
886293007749	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
886293007750	MPT binding site; other site
886293007751	trimer interface [polypeptide binding]; other site
886293007752	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
886293007753	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
886293007754	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
886293007755	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
886293007756	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
886293007757	dimer interface [polypeptide binding]; other site
886293007758	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
886293007759	metal binding site [ion binding]; metal-binding site
886293007760	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
886293007761	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
886293007762	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293007763	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
886293007764	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
886293007765	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
886293007766	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
886293007767	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293007768	Walker A/P-loop; other site
886293007769	ATP binding site [chemical binding]; other site
886293007770	Q-loop/lid; other site
886293007771	ABC transporter signature motif; other site
886293007772	Walker B; other site
886293007773	D-loop; other site
886293007774	H-loop/switch region; other site
886293007775	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293007776	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293007777	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293007778	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
886293007779	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293007780	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
886293007781	B12 binding site [chemical binding]; other site
886293007782	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
886293007783	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
886293007784	FeS/SAM binding site; other site
886293007785	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
886293007786	enoyl-CoA hydratase; Validated; Region: PRK08139
886293007787	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
886293007788	substrate binding site [chemical binding]; other site
886293007789	oxyanion hole (OAH) forming residues; other site
886293007790	trimer interface [polypeptide binding]; other site
886293007791	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
886293007792	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
886293007793	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
886293007794	ABC transporter; Region: ABC_tran_2; pfam12848
886293007795	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
886293007796	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
886293007797	amidase catalytic site [active]
886293007798	Zn binding residues [ion binding]; other site
886293007799	substrate binding site [chemical binding]; other site
886293007800	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293007801	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
886293007802	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
886293007803	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
886293007804	SnoaL-like domain; Region: SnoaL_2; pfam12680
886293007805	DNA ligase; Provisional; Region: PRK09125
886293007806	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
886293007807	DNA binding site [nucleotide binding]
886293007808	active site
886293007809	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
886293007810	DNA binding site [nucleotide binding]
886293007811	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
886293007812	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293007813	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
886293007814	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
886293007815	active site
886293007816	catalytic triad [active]
886293007817	oxyanion hole [active]
886293007818	Chlorophyllase enzyme; Region: Chlorophyllase2; pfam12740
886293007819	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
886293007820	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
886293007821	FtsX-like permease family; Region: FtsX; pfam02687
886293007822	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
886293007823	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
886293007824	Walker A/P-loop; other site
886293007825	ATP binding site [chemical binding]; other site
886293007826	Q-loop/lid; other site
886293007827	ABC transporter signature motif; other site
886293007828	Walker B; other site
886293007829	D-loop; other site
886293007830	H-loop/switch region; other site
886293007831	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
886293007832	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
886293007833	ATP binding site [chemical binding]; other site
886293007834	Walker B motif; other site
886293007835	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
886293007836	HSP70 interaction site [polypeptide binding]; other site
886293007837	Acyl transferase domain; Region: Acyl_transf_1; cl08282
886293007838	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
886293007839	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
886293007840	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
886293007841	active site
886293007842	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
886293007843	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
886293007844	substrate binding site [chemical binding]; other site
886293007845	oxyanion hole (OAH) forming residues; other site
886293007846	trimer interface [polypeptide binding]; other site
886293007847	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
886293007848	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
886293007849	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
886293007850	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
886293007851	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
886293007852	dimer interface [polypeptide binding]; other site
886293007853	active site
886293007854	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
886293007855	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
886293007856	DNA binding residues [nucleotide binding]
886293007857	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
886293007858	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
886293007859	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
886293007860	metal ion-dependent adhesion site (MIDAS); other site
886293007861	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293007862	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293007863	active site
886293007864	ATP binding site [chemical binding]; other site
886293007865	substrate binding site [chemical binding]; other site
886293007866	activation loop (A-loop); other site
886293007867	AAA domain; Region: AAA_22; pfam13401
886293007868	Uncharacterized conserved protein [Function unknown]; Region: COG1262
886293007869	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
886293007870	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293007871	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
886293007872	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
886293007873	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293007874	active site
886293007875	N-acetylglucosaminyltransferase II (MGAT2); Region: MGAT2; pfam05060
886293007876	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293007877	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
886293007878	protein-splicing catalytic site; other site
886293007879	thioester formation/cholesterol transfer; other site
886293007880	Pretoxin HINT domain; Region: PT-HINT; pfam07591
886293007881	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
886293007882	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
886293007883	putative active site [active]
886293007884	putative NTP binding site [chemical binding]; other site
886293007885	putative nucleic acid binding site [nucleotide binding]; other site
886293007886	SWIM zinc finger; Region: SWIM; pfam04434
886293007887	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293007888	structural tetrad; other site
886293007889	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293007890	HEAT repeats; Region: HEAT_2; pfam13646
886293007891	HEAT repeats; Region: HEAT_2; pfam13646
886293007892	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
886293007893	HEAT repeats; Region: HEAT_2; pfam13646
886293007894	HEAT repeats; Region: HEAT_2; pfam13646
886293007895	HEAT repeats; Region: HEAT_2; pfam13646
886293007896	breast cancer carboxy-terminal domain; Region: BRCT; smart00292
886293007897	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293007898	PAS domain; Region: PAS_9; pfam13426
886293007899	putative active site [active]
886293007900	heme pocket [chemical binding]; other site
886293007901	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293007902	dimer interface [polypeptide binding]; other site
886293007903	phosphorylation site [posttranslational modification]
886293007904	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293007905	ATP binding site [chemical binding]; other site
886293007906	Mg2+ binding site [ion binding]; other site
886293007907	G-X-G motif; other site
886293007908	Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607
886293007909	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293007910	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293007911	catalytic residues [active]
886293007912	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
886293007913	G1 box; other site
886293007914	GTP/Mg2+ binding site [chemical binding]; other site
886293007915	G2 box; other site
886293007916	Switch I region; other site
886293007917	G3 box; other site
886293007918	Switch II region; other site
886293007919	G4 box; other site
886293007920	Uncharacterized conserved protein [Function unknown]; Region: COG1262
886293007921	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
886293007922	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
886293007923	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
886293007924	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293007925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293007926	active site
886293007927	phosphorylation site [posttranslational modification]
886293007928	intermolecular recognition site; other site
886293007929	dimerization interface [polypeptide binding]; other site
886293007930	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
886293007931	putative binding surface; other site
886293007932	active site
886293007933	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293007934	ATP binding site [chemical binding]; other site
886293007935	Mg2+ binding site [ion binding]; other site
886293007936	G-X-G motif; other site
886293007937	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
886293007938	Response regulator receiver domain; Region: Response_reg; pfam00072
886293007939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293007940	active site
886293007941	phosphorylation site [posttranslational modification]
886293007942	intermolecular recognition site; other site
886293007943	dimerization interface [polypeptide binding]; other site
886293007944	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
886293007945	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
886293007946	dimer interface [polypeptide binding]; other site
886293007947	putative CheW interface [polypeptide binding]; other site
886293007948	CheW-like domain; Region: CheW; pfam01584
886293007949	OsmC-like protein; Region: OsmC; pfam02566
886293007950	Haemolysin-III related; Region: HlyIII; pfam03006
886293007951	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
886293007952	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
886293007953	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
886293007954	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293007955	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293007956	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293007957	DNA binding residues [nucleotide binding]
886293007958	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293007959	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293007960	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293007961	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293007962	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293007963	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293007964	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293007965	catalytic residues [active]
886293007966	methionine sulfoxide reductase A; Provisional; Region: PRK14054
886293007967	PAS fold; Region: PAS_4; pfam08448
886293007968	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293007969	putative active site [active]
886293007970	heme pocket [chemical binding]; other site
886293007971	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293007972	PAS fold; Region: PAS_3; pfam08447
886293007973	putative active site [active]
886293007974	heme pocket [chemical binding]; other site
886293007975	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293007976	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293007977	dimer interface [polypeptide binding]; other site
886293007978	phosphorylation site [posttranslational modification]
886293007979	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293007980	ATP binding site [chemical binding]; other site
886293007981	Mg2+ binding site [ion binding]; other site
886293007982	G-X-G motif; other site
886293007983	Response regulator receiver domain; Region: Response_reg; pfam00072
886293007984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293007985	active site
886293007986	phosphorylation site [posttranslational modification]
886293007987	intermolecular recognition site; other site
886293007988	dimerization interface [polypeptide binding]; other site
886293007989	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
886293007990	Suppression of tumorigenicity 7; Region: ST7; cd11557
886293007991	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
886293007992	AMP nucleosidase; Provisional; Region: PRK07115
886293007993	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293007994	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
886293007995	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
886293007996	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
886293007997	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
886293007998	putative active site [active]
886293007999	putative NTP binding site [chemical binding]; other site
886293008000	putative nucleic acid binding site [nucleotide binding]; other site
886293008001	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
886293008002	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
886293008003	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293008004	Sulfatase; Region: Sulfatase; pfam00884
886293008005	Sulfatase; Region: Sulfatase; cl17466
886293008006	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293008007	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293008008	Major Facilitator Superfamily; Region: MFS_1; pfam07690
886293008009	putative substrate translocation pore; other site
886293008010	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
886293008011	homotrimer interaction site [polypeptide binding]; other site
886293008012	putative active site [active]
886293008013	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
886293008014	homotrimer interaction site [polypeptide binding]; other site
886293008015	putative active site [active]
886293008016	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
886293008017	homotrimer interaction site [polypeptide binding]; other site
886293008018	putative active site [active]
886293008019	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
886293008020	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
886293008021	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293008022	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293008023	dimerization interface [polypeptide binding]; other site
886293008024	putative DNA binding site [nucleotide binding]; other site
886293008025	putative Zn2+ binding site [ion binding]; other site
886293008026	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
886293008027	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293008028	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
886293008029	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293008030	active site
886293008031	motif I; other site
886293008032	motif II; other site
886293008033	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293008034	Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900
886293008035	Protein of unknown function (DUF1223); Region: DUF1223; cl10501
886293008036	Transcriptional regulator [Transcription]; Region: LysR; COG0583
886293008037	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
886293008038	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
886293008039	dimerization interface [polypeptide binding]; other site
886293008040	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008041	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293008042	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293008043	catalytic residues [active]
886293008044	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
886293008045	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293008046	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
886293008047	metal ion-dependent adhesion site (MIDAS); other site
886293008048	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
886293008049	Filamin/ABP280 repeat; Region: Filamin; pfam00630
886293008050	N-terminal double-transmembrane domain; Region: two_anch; TIGR02226
886293008051	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
886293008052	Protein of unknown function DUF58; Region: DUF58; pfam01882
886293008053	von Willebrand factor type A domain; Region: VWA_2; pfam13519
886293008054	metal ion-dependent adhesion site (MIDAS); other site
886293008055	MoxR-like ATPases [General function prediction only]; Region: COG0714
886293008056	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293008057	Walker A motif; other site
886293008058	ATP binding site [chemical binding]; other site
886293008059	Walker B motif; other site
886293008060	arginine finger; other site
886293008061	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
886293008062	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
886293008063	active site
886293008064	catalytic tetrad [active]
886293008065	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008066	prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294
886293008067	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
886293008068	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293008069	non-specific DNA binding site [nucleotide binding]; other site
886293008070	salt bridge; other site
886293008071	sequence-specific DNA binding site [nucleotide binding]; other site
886293008072	PBP superfamily domain; Region: PBP_like; pfam12727
886293008073	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008074	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
886293008075	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293008076	S-adenosylmethionine binding site [chemical binding]; other site
886293008077	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
886293008078	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
886293008079	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
886293008080	potential catalytic triad [active]
886293008081	conserved cys residue [active]
886293008082	YfdX protein; Region: YfdX; pfam10938
886293008083	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
886293008084	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
886293008085	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
886293008086	nucleotide binding site [chemical binding]; other site
886293008087	NEF interaction site [polypeptide binding]; other site
886293008088	SBD interface [polypeptide binding]; other site
886293008089	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
886293008090	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293008091	S-adenosylmethionine binding site [chemical binding]; other site
886293008092	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
886293008093	active site
886293008094	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
886293008095	active site
886293008096	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
886293008097	catalytic tetrad [active]
886293008098	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
886293008099	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
886293008100	FMN binding site [chemical binding]; other site
886293008101	active site
886293008102	substrate binding site [chemical binding]; other site
886293008103	catalytic residue [active]
886293008104	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293008105	dimerization interface [polypeptide binding]; other site
886293008106	putative DNA binding site [nucleotide binding]; other site
886293008107	putative Zn2+ binding site [ion binding]; other site
886293008108	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
886293008109	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
886293008110	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293008111	Sulfatase; Region: Sulfatase; pfam00884
886293008112	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293008113	Cytochrome c; Region: Cytochrom_C; pfam00034
886293008114	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
886293008115	homotrimer interaction site [polypeptide binding]; other site
886293008116	putative active site [active]
886293008117	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
886293008118	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
886293008119	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
886293008120	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
886293008121	Metal-binding active site; metal-binding site
886293008122	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
886293008123	dimerization interface [polypeptide binding]; other site
886293008124	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008125	prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294
886293008126	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
886293008127	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
886293008128	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
886293008129	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
886293008130	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
886293008131	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
886293008132	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
886293008133	Protein phosphatase 2C; Region: PP2C; pfam00481
886293008134	active site
886293008135	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
886293008136	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
886293008137	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
886293008138	catalytic residue [active]
886293008139	Haemolytic domain; Region: Haemolytic; pfam01809
886293008140	Ribonuclease P; Region: Ribonuclease_P; pfam00825
886293008141	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
886293008142	DNA binding residues [nucleotide binding]
886293008143	chaperone protein DnaJ; Provisional; Region: PRK14299
886293008144	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
886293008145	HSP70 interaction site [polypeptide binding]; other site
886293008146	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
886293008147	substrate binding site [polypeptide binding]; other site
886293008148	dimer interface [polypeptide binding]; other site
886293008149	antiporter inner membrane protein; Provisional; Region: PRK11670
886293008150	Domain of unknown function DUF59; Region: DUF59; pfam01883
886293008151	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
886293008152	Walker A motif; other site
886293008153	G8 domain; Region: G8; pfam10162
886293008154	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008155	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293008156	binding surface
886293008157	Tetratricopeptide repeat; Region: TPR_16; pfam13432
886293008158	TPR motif; other site
886293008159	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
886293008160	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293008161	non-specific DNA binding site [nucleotide binding]; other site
886293008162	salt bridge; other site
886293008163	sequence-specific DNA binding site [nucleotide binding]; other site
886293008164	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
886293008165	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
886293008166	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
886293008167	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
886293008168	putative active site; other site
886293008169	catalytic triad [active]
886293008170	putative dimer interface [polypeptide binding]; other site
886293008171	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
886293008172	homotrimer interaction site [polypeptide binding]; other site
886293008173	putative active site [active]
886293008174	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
886293008175	classical (c) SDRs; Region: SDR_c; cd05233
886293008176	NAD(P) binding site [chemical binding]; other site
886293008177	active site
886293008178	hypothetical protein; Provisional; Region: PRK02947
886293008179	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
886293008180	putative active site [active]
886293008181	Response regulator receiver domain; Region: Response_reg; pfam00072
886293008182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293008183	active site
886293008184	phosphorylation site [posttranslational modification]
886293008185	intermolecular recognition site; other site
886293008186	dimerization interface [polypeptide binding]; other site
886293008187	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
886293008188	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
886293008189	metal binding site [ion binding]; metal-binding site
886293008190	active site
886293008191	I-site; other site
886293008192	glyoxylate reductase; Reviewed; Region: PRK13243
886293008193	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
886293008194	dimerization interface [polypeptide binding]; other site
886293008195	ligand binding site [chemical binding]; other site
886293008196	NADP binding site [chemical binding]; other site
886293008197	catalytic site [active]
886293008198	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
886293008199	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293008200	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293008201	active site
886293008202	ATP binding site [chemical binding]; other site
886293008203	substrate binding site [chemical binding]; other site
886293008204	activation loop (A-loop); other site
886293008205	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293008206	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
886293008207	phosphopeptide binding site; other site
886293008208	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
886293008209	GAF domain; Region: GAF_3; pfam13492
886293008210	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
886293008211	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
886293008212	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
886293008213	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
886293008214	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
886293008215	active site
886293008216	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293008217	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
886293008218	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
886293008219	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
886293008220	signal recognition particle protein; Provisional; Region: PRK10867
886293008221	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
886293008222	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
886293008223	P loop; other site
886293008224	GTP binding site [chemical binding]; other site
886293008225	Signal peptide binding domain; Region: SRP_SPB; pfam02978
886293008226	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
886293008227	dimer interface [polypeptide binding]; other site
886293008228	catalytic triad [active]
886293008229	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
886293008230	MraW methylase family; Region: Methyltransf_5; cl17771
886293008231	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
886293008232	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
886293008233	putative ligand binding site [chemical binding]; other site
886293008234	putative NAD binding site [chemical binding]; other site
886293008235	catalytic site [active]
886293008236	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
886293008237	Sulfate transporter family; Region: Sulfate_transp; pfam00916
886293008238	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
886293008239	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293008240	putative active site [active]
886293008241	heme pocket [chemical binding]; other site
886293008242	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293008243	dimer interface [polypeptide binding]; other site
886293008244	phosphorylation site [posttranslational modification]
886293008245	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293008246	ATP binding site [chemical binding]; other site
886293008247	Mg2+ binding site [ion binding]; other site
886293008248	G-X-G motif; other site
886293008249	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
886293008250	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293008251	active site
886293008252	phosphorylation site [posttranslational modification]
886293008253	intermolecular recognition site; other site
886293008254	dimerization interface [polypeptide binding]; other site
886293008255	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293008256	Walker A motif; other site
886293008257	ATP binding site [chemical binding]; other site
886293008258	Walker B motif; other site
886293008259	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
886293008260	Homeodomain-like domain; Region: HTH_23; pfam13384
886293008261	Winged helix-turn helix; Region: HTH_29; pfam13551
886293008262	Homeodomain-like domain; Region: HTH_32; pfam13565
886293008263	DDE superfamily endonuclease; Region: DDE_3; pfam13358
886293008264	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
886293008265	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293008266	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293008267	active site
886293008268	phosphorylation site [posttranslational modification]
886293008269	intermolecular recognition site; other site
886293008270	dimerization interface [polypeptide binding]; other site
886293008271	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
886293008272	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
886293008273	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
886293008274	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293008275	putative active site [active]
886293008276	heme pocket [chemical binding]; other site
886293008277	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293008278	dimer interface [polypeptide binding]; other site
886293008279	phosphorylation site [posttranslational modification]
886293008280	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293008281	ATP binding site [chemical binding]; other site
886293008282	Mg2+ binding site [ion binding]; other site
886293008283	G-X-G motif; other site
886293008284	Response regulator receiver domain; Region: Response_reg; pfam00072
886293008285	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293008286	active site
886293008287	phosphorylation site [posttranslational modification]
886293008288	intermolecular recognition site; other site
886293008289	dimerization interface [polypeptide binding]; other site
886293008290	Response regulator receiver domain; Region: Response_reg; pfam00072
886293008291	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293008292	active site
886293008293	phosphorylation site [posttranslational modification]
886293008294	intermolecular recognition site; other site
886293008295	dimerization interface [polypeptide binding]; other site
886293008296	Hpt domain; Region: Hpt; pfam01627
886293008297	putative binding surface; other site
886293008298	active site
886293008299	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
886293008300	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
886293008301	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
886293008302	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
886293008303	catalytic residue [active]
886293008304	Methyltransferase domain; Region: Methyltransf_31; pfam13847
886293008305	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293008306	S-adenosylmethionine binding site [chemical binding]; other site
886293008307	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
886293008308	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
886293008309	active site
886293008310	FMN binding site [chemical binding]; other site
886293008311	substrate binding site [chemical binding]; other site
886293008312	putative catalytic residue [active]
886293008313	thymidylate synthase; Reviewed; Region: thyA; PRK01827
886293008314	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
886293008315	dimerization interface [polypeptide binding]; other site
886293008316	active site
886293008317	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
886293008318	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
886293008319	folate binding site [chemical binding]; other site
886293008320	NADP+ binding site [chemical binding]; other site
886293008321	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
886293008322	cyclophilin_ABH_like: Cyclophilin  A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which...; Region: cyclophilin_ABH_like; cd01926
886293008323	active site
886293008324	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
886293008325	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293008326	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293008327	active site
886293008328	ATP binding site [chemical binding]; other site
886293008329	substrate binding site [chemical binding]; other site
886293008330	activation loop (A-loop); other site
886293008331	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
886293008332	Isochorismatase family; Region: Isochorismatase; pfam00857
886293008333	catalytic triad [active]
886293008334	metal binding site [ion binding]; metal-binding site
886293008335	conserved cis-peptide bond; other site
886293008336	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293008337	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293008338	Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586
886293008339	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293008340	Haem-binding domain; Region: Haem_bd; pfam14376
886293008341	Protein of unknown function (DUF1587); Region: PSD3; pfam07626
886293008342	Protein of unknown function (DUF1595); Region: PSD5; pfam07637
886293008343	Protein of unknown function (DUF1592); Region: PSD4; pfam07631
886293008344	Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627
886293008345	Protein of unknown function (DUF1585); Region: PSD2; pfam07624
886293008346	Pollen proteins Ole e I like; Region: Pollen_Ole_e_I; pfam01190
886293008347	Cna protein B-type domain; Region: Cna_B; pfam05738
886293008348	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293008349	Coenzyme A binding pocket [chemical binding]; other site
886293008350	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008351	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
886293008352	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
886293008353	aspartate aminotransferase; Provisional; Region: PRK05764
886293008354	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
886293008355	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293008356	homodimer interface [polypeptide binding]; other site
886293008357	catalytic residue [active]
886293008358	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
886293008359	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
886293008360	active site
886293008361	putative substrate binding pocket [chemical binding]; other site
886293008362	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293008363	Radical SAM superfamily; Region: Radical_SAM; pfam04055
886293008364	HemN C-terminal domain; Region: HemN_C; pfam06969
886293008365	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293008366	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293008367	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293008368	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293008369	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
886293008370	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293008371	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293008372	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
886293008373	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
886293008374	homodimer interface [polypeptide binding]; other site
886293008375	putative substrate binding pocket [chemical binding]; other site
886293008376	diiron center [ion binding]; other site
886293008377	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293008378	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293008379	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293008380	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
886293008381	active site
886293008382	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
886293008383	active site
886293008384	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293008385	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
886293008386	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293008387	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293008388	active site
886293008389	ATP binding site [chemical binding]; other site
886293008390	substrate binding site [chemical binding]; other site
886293008391	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293008392	substrate binding site [chemical binding]; other site
886293008393	activation loop (A-loop); other site
886293008394	activation loop (A-loop); other site
886293008395	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293008396	structural tetrad; other site
886293008397	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293008398	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293008399	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293008400	structural tetrad; other site
886293008401	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293008402	structural tetrad; other site
886293008403	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293008404	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293008405	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008406	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
886293008407	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008408	RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984
886293008409	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293008410	DNA binding residues [nucleotide binding]
886293008411	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293008412	active site
886293008413	ATP binding site [chemical binding]; other site
886293008414	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293008415	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293008416	substrate binding site [chemical binding]; other site
886293008417	activation loop (A-loop); other site
886293008418	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293008419	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293008420	DDE superfamily endonuclease; Region: DDE_5; pfam13546
886293008421	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293008422	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293008423	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293008424	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
886293008425	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
886293008426	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
886293008427	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
886293008428	Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979
886293008429	active site
886293008430	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
886293008431	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
886293008432	FMN binding site [chemical binding]; other site
886293008433	substrate binding site [chemical binding]; other site
886293008434	putative catalytic residue [active]
886293008435	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
886293008436	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
886293008437	active site
886293008438	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
886293008439	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
886293008440	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
886293008441	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
886293008442	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
886293008443	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
886293008444	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
886293008445	putative NADP binding site [chemical binding]; other site
886293008446	active site
886293008447	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
886293008448	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
886293008449	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
886293008450	active site
886293008451	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
886293008452	active site
886293008453	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
886293008454	Acyl transferase domain; Region: Acyl_transf_1; cl08282
886293008455	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
886293008456	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
886293008457	active site 2 [active]
886293008458	active site 1 [active]
886293008459	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
886293008460	active site 1 [active]
886293008461	dimer interface [polypeptide binding]; other site
886293008462	active site 2 [active]
886293008463	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
886293008464	active site 2 [active]
886293008465	active site 1 [active]
886293008466	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
886293008467	active site 2 [active]
886293008468	active site 1 [active]
886293008469	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258
886293008470	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
886293008471	dimer interface [polypeptide binding]; other site
886293008472	active site
886293008473	CoA binding pocket [chemical binding]; other site
886293008474	haloalkane dehalogenase; Provisional; Region: PRK00870
886293008475	peptide synthase; Provisional; Region: PRK09274
886293008476	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910
886293008477	acyl-activating enzyme (AAE) consensus motif; other site
886293008478	putative AMP binding site [chemical binding]; other site
886293008479	putative active site [active]
886293008480	putative CoA binding site [chemical binding]; other site
886293008481	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293008482	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
886293008483	NAD(P) binding site [chemical binding]; other site
886293008484	active site
886293008485	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
886293008486	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293008487	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
886293008488	putative substrate translocation pore; other site
886293008489	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
886293008490	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
886293008491	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293008492	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293008493	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
886293008494	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
886293008495	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008496	prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294
886293008497	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008498	prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294
886293008499	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
886293008500	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
886293008501	Subunit I/III interface [polypeptide binding]; other site
886293008502	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
886293008503	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
886293008504	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
886293008505	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
886293008506	Cytochrome c; Region: Cytochrom_C; pfam00034
886293008507	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
886293008508	Cu(I) binding site [ion binding]; other site
886293008509	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
886293008510	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
886293008511	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
886293008512	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
886293008513	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
886293008514	molybdopterin cofactor binding site; other site
886293008515	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
886293008516	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
886293008517	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
886293008518	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
886293008519	heme-binding residues [chemical binding]; other site
886293008520	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
886293008521	putative efflux protein, MATE family; Region: matE; TIGR00797
886293008522	cation binding site [ion binding]; other site
886293008523	Transposase domain (DUF772); Region: DUF772; pfam05598
886293008524	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
886293008525	DDE superfamily endonuclease; Region: DDE_5; cl17874
886293008526	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
886293008527	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
886293008528	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
886293008529	Leucine rich repeat; Region: LRR_8; pfam13855
886293008530	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
886293008531	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
886293008532	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293008533	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
886293008534	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
886293008535	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
886293008536	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
886293008537	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
886293008538	CheB methylesterase; Region: CheB_methylest; pfam01339
886293008539	Response regulator receiver domain; Region: Response_reg; pfam00072
886293008540	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293008541	active site
886293008542	phosphorylation site [posttranslational modification]
886293008543	intermolecular recognition site; other site
886293008544	dimerization interface [polypeptide binding]; other site
886293008545	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
886293008546	dimerization interface [polypeptide binding]; other site
886293008547	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
886293008548	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
886293008549	dimer interface [polypeptide binding]; other site
886293008550	putative CheW interface [polypeptide binding]; other site
886293008551	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
886293008552	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
886293008553	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
886293008554	putative binding surface; other site
886293008555	active site
886293008556	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
886293008557	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293008558	ATP binding site [chemical binding]; other site
886293008559	Mg2+ binding site [ion binding]; other site
886293008560	G-X-G motif; other site
886293008561	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
886293008562	CheW-like domain; Region: CheW; pfam01584
886293008563	PAS fold; Region: PAS_4; pfam08448
886293008564	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293008565	putative active site [active]
886293008566	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
886293008567	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
886293008568	metal binding site [ion binding]; metal-binding site
886293008569	active site
886293008570	I-site; other site
886293008571	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
886293008572	CheC-like family; Region: CheC; pfam04509
886293008573	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293008574	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293008575	active site
886293008576	phosphorylation site [posttranslational modification]
886293008577	intermolecular recognition site; other site
886293008578	dimerization interface [polypeptide binding]; other site
886293008579	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
886293008580	putative catalytic site [active]
886293008581	putative metal binding site [ion binding]; other site
886293008582	putative phosphate binding site [ion binding]; other site
886293008583	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293008584	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008585	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
886293008586	active site
886293008587	ribulose/triose binding site [chemical binding]; other site
886293008588	phosphate binding site [ion binding]; other site
886293008589	substrate (anthranilate) binding pocket [chemical binding]; other site
886293008590	product (indole) binding pocket [chemical binding]; other site
886293008591	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
886293008592	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
886293008593	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
886293008594	Ligand binding site; other site
886293008595	Putative Catalytic site; other site
886293008596	DXD motif; other site
886293008597	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
886293008598	ParB-like nuclease domain; Region: ParB; smart00470
886293008599	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
886293008600	DNA methylase; Region: N6_N4_Mtase; cl17433
886293008601	Methyltransferase domain; Region: Methyltransf_26; pfam13659
886293008602	Helix-turn-helix domain; Region: HTH_36; pfam13730
886293008603	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
886293008604	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
886293008605	MoaE homodimer interface [polypeptide binding]; other site
886293008606	MoaD interaction [polypeptide binding]; other site
886293008607	active site residues [active]
886293008608	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
886293008609	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
886293008610	FeS/SAM binding site; other site
886293008611	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
886293008612	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
886293008613	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
886293008614	metal binding site [ion binding]; metal-binding site
886293008615	substrate binding pocket [chemical binding]; other site
886293008616	Flagellin N-methylase; Region: FliB; pfam03692
886293008617	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
886293008618	IHF dimer interface [polypeptide binding]; other site
886293008619	IHF - DNA interface [nucleotide binding]; other site
886293008620	active site
886293008621	catalytic site [active]
886293008622	substrate binding site [chemical binding]; other site
886293008623	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
886293008624	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293008625	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293008626	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
886293008627	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
886293008628	active site
886293008629	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
886293008630	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
886293008631	catalytic motif [active]
886293008632	Zn binding site [ion binding]; other site
886293008633	RibD C-terminal domain; Region: RibD_C; cl17279
886293008634	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
886293008635	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
886293008636	CoA binding domain; Region: CoA_binding; smart00881
886293008637	Caspase domain; Region: Peptidase_C14; pfam00656
886293008638	CHAT domain; Region: CHAT; pfam12770
886293008639	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
886293008640	Caspase domain; Region: Peptidase_C14; pfam00656
886293008641	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
886293008642	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
886293008643	substrate binding site [chemical binding]; other site
886293008644	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
886293008645	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
886293008646	substrate binding site [chemical binding]; other site
886293008647	ligand binding site [chemical binding]; other site
886293008648	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
886293008649	amphipathic channel; other site
886293008650	Asn-Pro-Ala signature motifs; other site
886293008651	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008652	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293008653	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
886293008654	DNA binding residues [nucleotide binding]
886293008655	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293008656	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293008657	active site
886293008658	ATP binding site [chemical binding]; other site
886293008659	substrate binding site [chemical binding]; other site
886293008660	activation loop (A-loop); other site
886293008661	The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693
886293008662	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
886293008663	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293008664	putative catalytic residue [active]
886293008665	Haem-binding domain; Region: Haem_bd; pfam14376
886293008666	Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712
886293008667	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
886293008668	glycogen binding site [chemical binding]; other site
886293008669	Right handed beta helix region; Region: Beta_helix; pfam13229
886293008670	Pirin-related protein [General function prediction only]; Region: COG1741
886293008671	Pirin; Region: Pirin; pfam02678
886293008672	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
886293008673	Predicted flavoprotein [General function prediction only]; Region: COG0431
886293008674	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
886293008675	Isochorismatase family; Region: Isochorismatase; pfam00857
886293008676	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
886293008677	catalytic triad [active]
886293008678	dimer interface [polypeptide binding]; other site
886293008679	conserved cis-peptide bond; other site
886293008680	Predicted transcriptional regulators [Transcription]; Region: COG1733
886293008681	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293008682	dimerization interface [polypeptide binding]; other site
886293008683	putative DNA binding site [nucleotide binding]; other site
886293008684	putative Zn2+ binding site [ion binding]; other site
886293008685	lipoyl synthase; Provisional; Region: PRK05481
886293008686	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
886293008687	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293008688	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293008689	NAD(P) binding site [chemical binding]; other site
886293008690	active site
886293008691	mercuric reductase; Validated; Region: PRK06370
886293008692	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
886293008693	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
886293008694	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
886293008695	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
886293008696	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008697	Transthyretin_like.  This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase).  TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222
886293008698	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
886293008699	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
886293008700	chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465
886293008701	active site
886293008702	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
886293008703	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
886293008704	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
886293008705	NAD(P) binding site [chemical binding]; other site
886293008706	Beta-lactamase; Region: Beta-lactamase; pfam00144
886293008707	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
886293008708	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
886293008709	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
886293008710	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293008711	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293008712	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
886293008713	DHH family; Region: DHH; pfam01368
886293008714	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
886293008715	Repair protein; Region: Repair_PSII; pfam04536
886293008716	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293008717	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
886293008718	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
886293008719	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
886293008720	active site
886293008721	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
886293008722	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
886293008723	carboxyltransferase (CT) interaction site; other site
886293008724	biotinylation site [posttranslational modification]; other site
886293008725	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
886293008726	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
886293008727	ATP-grasp domain; Region: ATP-grasp_4; cl17255
886293008728	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
886293008729	phosphofructokinase; Region: PFK_mixed; TIGR02483
886293008730	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
886293008731	active site
886293008732	ADP/pyrophosphate binding site [chemical binding]; other site
886293008733	dimerization interface [polypeptide binding]; other site
886293008734	allosteric effector site; other site
886293008735	fructose-1,6-bisphosphate binding site; other site
886293008736	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
886293008737	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
886293008738	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293008739	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293008740	DNA binding residues [nucleotide binding]
886293008741	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
886293008742	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
886293008743	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
886293008744	domain interfaces; other site
886293008745	active site
886293008746	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
886293008747	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
886293008748	Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152
886293008749	Phosphotransferase enzyme family; Region: APH; pfam01636
886293008750	putative active site [active]
886293008751	putative substrate binding site [chemical binding]; other site
886293008752	ATP binding site [chemical binding]; other site
886293008753	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
886293008754	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
886293008755	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
886293008756	Walker A/P-loop; other site
886293008757	ATP binding site [chemical binding]; other site
886293008758	Q-loop/lid; other site
886293008759	ABC transporter signature motif; other site
886293008760	Walker B; other site
886293008761	D-loop; other site
886293008762	H-loop/switch region; other site
886293008763	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
886293008764	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293008765	NAD(P) binding site [chemical binding]; other site
886293008766	active site
886293008767	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293008768	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293008769	Trehalose utilisation; Region: ThuA; pfam06283
886293008770	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
886293008771	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
886293008772	AP (apurinic/apyrimidinic) site pocket; other site
886293008773	DNA interaction; other site
886293008774	Metal-binding active site; metal-binding site
886293008775	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293008776	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293008777	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293008778	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
886293008779	Transcriptional regulator [Transcription]; Region: IclR; COG1414
886293008780	Bacterial transcriptional regulator; Region: IclR; pfam01614
886293008781	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
886293008782	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
886293008783	active site pocket [active]
886293008784	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
886293008785	active site
886293008786	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
886293008787	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
886293008788	Ligand binding site; other site
886293008789	Putative Catalytic site; other site
886293008790	DXD motif; other site
886293008791	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008792	Protein of unknown function (DUF1583); Region: DUF1583; pfam07622
886293008793	DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188
886293008794	Ligand binding site; other site
886293008795	Ligand binding site; other site
886293008796	Ligand binding site; other site
886293008797	Putative Catalytic site; other site
886293008798	DXD motif; other site
886293008799	Uncharacterized conserved protein [Function unknown]; Region: COG2006
886293008800	Domain of unknown function (DUF362); Region: DUF362; pfam04015
886293008801	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
886293008802	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293008803	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
886293008804	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
886293008805	putative active site [active]
886293008806	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
886293008807	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
886293008808	active site
886293008809	catalytic residues [active]
886293008810	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
886293008811	Bulb-type mannose-specific lectin; Region: B_lectin; smart00108
886293008812	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
886293008813	dimerization interface [polypeptide binding]; other site
886293008814	mannose binding site [chemical binding]; other site
886293008815	Bulb-type mannose-specific lectin; Region: B_lectin; smart00108
886293008816	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
886293008817	dimerization interface [polypeptide binding]; other site
886293008818	mannose binding site [chemical binding]; other site
886293008819	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293008820	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293008821	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293008822	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293008823	active site
886293008824	ATP binding site [chemical binding]; other site
886293008825	substrate binding site [chemical binding]; other site
886293008826	activation loop (A-loop); other site
886293008827	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293008828	phosphopeptide binding site; other site
886293008829	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
886293008830	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
886293008831	methionine sulfoxide reductase A; Provisional; Region: PRK14054
886293008832	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
886293008833	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
886293008834	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293008835	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293008836	active site
886293008837	ATP binding site [chemical binding]; other site
886293008838	substrate binding site [chemical binding]; other site
886293008839	activation loop (A-loop); other site
886293008840	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
886293008841	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
886293008842	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293008843	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
886293008844	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293008845	DNA binding residues [nucleotide binding]
886293008846	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
886293008847	active site
886293008848	catalytic triad [active]
886293008849	oxyanion hole [active]
886293008850	Caspase domain; Region: Peptidase_C14; pfam00656
886293008851	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
886293008852	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293008853	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293008854	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293008855	DNA binding residues [nucleotide binding]
886293008856	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
886293008857	Domain of unknown function (DUF4394); Region: DUF4394; pfam14339
886293008858	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
886293008859	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
886293008860	active site residue [active]
886293008861	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
886293008862	active site residue [active]
886293008863	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293008864	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293008865	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293008866	DNA binding residues [nucleotide binding]
886293008867	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
886293008868	Nitrogen regulatory protein P-II; Region: P-II; smart00938
886293008869	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
886293008870	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293008871	motif II; other site
886293008872	TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956
886293008873	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
886293008874	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
886293008875	Protein export membrane protein; Region: SecD_SecF; cl14618
886293008876	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293008877	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293008878	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
886293008879	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
886293008880	dihydroxyacetone kinase; Provisional; Region: PRK14479
886293008881	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
886293008882	DAK2 domain; Region: Dak2; pfam02734
886293008883	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293008884	TPR repeat; Region: TPR_11; pfam13414
886293008885	binding surface
886293008886	TPR motif; other site
886293008887	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
886293008888	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293008889	TPR motif; other site
886293008890	binding surface
886293008891	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293008892	binding surface
886293008893	TPR motif; other site
886293008894	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293008895	Walker A/P-loop; other site
886293008896	ATP binding site [chemical binding]; other site
886293008897	Q-loop/lid; other site
886293008898	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008899	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
886293008900	active site
886293008901	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
886293008902	hexokinase; Provisional; Region: PTZ00107
886293008903	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008904	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008905	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
886293008906	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
886293008907	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293008908	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
886293008909	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293008910	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008911	prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294
886293008912	DDE superfamily endonuclease; Region: DDE_5; pfam13546
886293008913	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
886293008914	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008915	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008916	Phytase; Region: Phytase; cl17685
886293008917	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008918	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293008919	Sulfatase; Region: Sulfatase; pfam00884
886293008920	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293008921	The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918
886293008922	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
886293008923	acyl-activating enzyme (AAE) consensus motif; other site
886293008924	AMP binding site [chemical binding]; other site
886293008925	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
886293008926	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
886293008927	putative trimer interface [polypeptide binding]; other site
886293008928	putative CoA binding site [chemical binding]; other site
886293008929	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
886293008930	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
886293008931	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
886293008932	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293008933	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293008934	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293008935	catalytic residues [active]
886293008936	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
886293008937	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
886293008938	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
886293008939	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
886293008940	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
886293008941	Ligand binding site; other site
886293008942	Putative Catalytic site; other site
886293008943	DXD motif; other site
886293008944	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
886293008945	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
886293008946	active site
886293008947	homodimer interface [polypeptide binding]; other site
886293008948	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
886293008949	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
886293008950	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
886293008951	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293008952	extended (e) SDRs; Region: SDR_e; cd08946
886293008953	NAD(P) binding site [chemical binding]; other site
886293008954	active site
886293008955	substrate binding site [chemical binding]; other site
886293008956	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293008957	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
886293008958	NAD binding site [chemical binding]; other site
886293008959	substrate binding site [chemical binding]; other site
886293008960	homodimer interface [polypeptide binding]; other site
886293008961	active site
886293008962	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
886293008963	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
886293008964	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293008965	active site
886293008966	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293008967	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293008968	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293008969	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293008970	Methyltransferase domain; Region: Methyltransf_23; pfam13489
886293008971	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293008972	S-adenosylmethionine binding site [chemical binding]; other site
886293008973	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
886293008974	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293008975	active site
886293008976	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293008977	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293008978	NAD(P) binding site [chemical binding]; other site
886293008979	active site
886293008980	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
886293008981	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
886293008982	NAD(P) binding site [chemical binding]; other site
886293008983	homodimer interface [polypeptide binding]; other site
886293008984	substrate binding site [chemical binding]; other site
886293008985	active site
886293008986	Chain length determinant protein; Region: Wzz; cl15801
886293008987	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
886293008988	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
886293008989	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
886293008990	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
886293008991	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
886293008992	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
886293008993	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
886293008994	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
886293008995	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
886293008996	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
886293008997	putative ADP-binding pocket [chemical binding]; other site
886293008998	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293008999	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293009000	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
886293009001	putative ADP-binding pocket [chemical binding]; other site
886293009002	O-Antigen ligase; Region: Wzy_C; pfam04932
886293009003	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293009004	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
886293009005	putative ADP-binding pocket [chemical binding]; other site
886293009006	Methyltransferase domain; Region: Methyltransf_31; pfam13847
886293009007	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293009008	S-adenosylmethionine binding site [chemical binding]; other site
886293009009	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
886293009010	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
886293009011	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
886293009012	active site
886293009013	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
886293009014	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
886293009015	active site
886293009016	dimer interface [polypeptide binding]; other site
886293009017	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
886293009018	Ligand Binding Site [chemical binding]; other site
886293009019	Molecular Tunnel; other site
886293009020	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293009021	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
886293009022	putative ADP-binding pocket [chemical binding]; other site
886293009023	Homeodomain-like domain; Region: HTH_23; pfam13384
886293009024	Winged helix-turn helix; Region: HTH_29; pfam13551
886293009025	Homeodomain-like domain; Region: HTH_32; pfam13565
886293009026	DDE superfamily endonuclease; Region: DDE_3; pfam13358
886293009027	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
886293009028	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293009029	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293009030	NAD(P) binding site [chemical binding]; other site
886293009031	active site
886293009032	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
886293009033	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
886293009034	Mg++ binding site [ion binding]; other site
886293009035	putative catalytic motif [active]
886293009036	putative substrate binding site [chemical binding]; other site
886293009037	Homeodomain-like domain; Region: HTH_23; pfam13384
886293009038	Winged helix-turn helix; Region: HTH_29; pfam13551
886293009039	Homeodomain-like domain; Region: HTH_32; pfam13565
886293009040	DDE superfamily endonuclease; Region: DDE_3; pfam13358
886293009041	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
886293009042	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
886293009043	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
886293009044	Ligand binding site; other site
886293009045	Putative Catalytic site; other site
886293009046	DXD motif; other site
886293009047	Methyltransferase domain; Region: Methyltransf_23; pfam13489
886293009048	Methyltransferase domain; Region: Methyltransf_11; pfam08241
886293009049	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293009050	S-adenosylmethionine binding site [chemical binding]; other site
886293009051	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293009052	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
886293009053	NAD binding site [chemical binding]; other site
886293009054	substrate binding site [chemical binding]; other site
886293009055	homodimer interface [polypeptide binding]; other site
886293009056	active site
886293009057	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
886293009058	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
886293009059	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
886293009060	NAD binding site [chemical binding]; other site
886293009061	substrate binding site [chemical binding]; other site
886293009062	homodimer interface [polypeptide binding]; other site
886293009063	active site
886293009064	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
886293009065	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
886293009066	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
886293009067	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
886293009068	DNA-binding site [nucleotide binding]; DNA binding site
886293009069	UTRA domain; Region: UTRA; pfam07702
886293009070	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
886293009071	Penicillinase repressor; Region: Pencillinase_R; pfam03965
886293009072	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
886293009073	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293009074	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293009075	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293009076	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
886293009077	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
886293009078	substrate binding site; other site
886293009079	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293009080	NAD(P) binding site [chemical binding]; other site
886293009081	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293009082	active site
886293009083	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
886293009084	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
886293009085	inhibitor-cofactor binding pocket; inhibition site
886293009086	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293009087	catalytic residue [active]
886293009088	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293009089	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293009090	NAD(P) binding site [chemical binding]; other site
886293009091	active site
886293009092	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
886293009093	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
886293009094	Ligand binding site; other site
886293009095	Putative Catalytic site; other site
886293009096	DXD motif; other site
886293009097	Methyltransferase domain; Region: Methyltransf_23; pfam13489
886293009098	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293009099	S-adenosylmethionine binding site [chemical binding]; other site
886293009100	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
886293009101	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
886293009102	PYR/PP interface [polypeptide binding]; other site
886293009103	dimer interface [polypeptide binding]; other site
886293009104	TPP binding site [chemical binding]; other site
886293009105	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
886293009106	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
886293009107	TPP-binding site [chemical binding]; other site
886293009108	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
886293009109	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
886293009110	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293009111	NAD(P) binding site [chemical binding]; other site
886293009112	active site
886293009113	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
886293009114	active site
886293009115	NAD binding site [chemical binding]; other site
886293009116	metal binding site [ion binding]; metal-binding site
886293009117	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
886293009118	Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241
886293009119	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293009120	active site
886293009121	motif I; other site
886293009122	motif II; other site
886293009123	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
886293009124	FHA domain; Region: FHA; pfam00498
886293009125	phosphopeptide binding site; other site
886293009126	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293009127	phosphopeptide binding site; other site
886293009128	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293009129	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293009130	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
886293009131	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293009132	dimerization interface [polypeptide binding]; other site
886293009133	putative DNA binding site [nucleotide binding]; other site
886293009134	putative Zn2+ binding site [ion binding]; other site
886293009135	RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984
886293009136	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293009137	DNA binding residues [nucleotide binding]
886293009138	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293009139	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293009140	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293009141	substrate binding site [chemical binding]; other site
886293009142	activation loop (A-loop); other site
886293009143	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293009144	WD40 repeats; Region: WD40; smart00320
886293009145	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293009146	structural tetrad; other site
886293009147	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293009148	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293009149	structural tetrad; other site
886293009150	WD domain, G-beta repeat; Region: WD40; pfam00400
886293009151	WD domain, G-beta repeat; Region: WD40; pfam00400
886293009152	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293009153	TPR motif; other site
886293009154	binding surface
886293009155	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
886293009156	Right handed beta helix region; Region: Beta_helix; pfam13229
886293009157	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
886293009158	CoA binding domain; Region: CoA_binding_2; pfam13380
886293009159	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
886293009160	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
886293009161	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
886293009162	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
886293009163	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
886293009164	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
886293009165	putative active site [active]
886293009166	catalytic site [active]
886293009167	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
886293009168	putative active site [active]
886293009169	catalytic site [active]
886293009170	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293009171	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293009172	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293009173	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293009174	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293009175	Helix-turn-helix domain; Region: HTH_17; cl17695
886293009176	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
886293009177	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
886293009178	putative heme binding pocket [chemical binding]; other site
886293009179	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
886293009180	TIGR03032 family protein; Region: TIGR03032
886293009181	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
886293009182	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
886293009183	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
886293009184	PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_1; cd04820
886293009185	PA/protease or protease-like domain interface [polypeptide binding]; other site
886293009186	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661
886293009187	Peptidase family M28; Region: Peptidase_M28; pfam04389
886293009188	metal binding site [ion binding]; metal-binding site
886293009189	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
886293009190	PAS fold; Region: PAS_4; pfam08448
886293009191	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293009192	putative active site [active]
886293009193	heme pocket [chemical binding]; other site
886293009194	PAS domain S-box; Region: sensory_box; TIGR00229
886293009195	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293009196	putative active site [active]
886293009197	heme pocket [chemical binding]; other site
886293009198	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
886293009199	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293009200	putative active site [active]
886293009201	heme pocket [chemical binding]; other site
886293009202	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293009203	dimer interface [polypeptide binding]; other site
886293009204	phosphorylation site [posttranslational modification]
886293009205	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293009206	ATP binding site [chemical binding]; other site
886293009207	Mg2+ binding site [ion binding]; other site
886293009208	G-X-G motif; other site
886293009209	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293009210	Response regulator receiver domain; Region: Response_reg; pfam00072
886293009211	active site
886293009212	phosphorylation site [posttranslational modification]
886293009213	intermolecular recognition site; other site
886293009214	dimerization interface [polypeptide binding]; other site
886293009215	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
886293009216	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293009217	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293009218	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293009219	transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309
886293009220	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
886293009221	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
886293009222	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
886293009223	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
886293009224	metal ion-dependent adhesion site (MIDAS); other site
886293009225	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
886293009226	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
886293009227	Protein of unknown function DUF58; Region: DUF58; pfam01882
886293009228	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
886293009229	metal ion-dependent adhesion site (MIDAS); other site
886293009230	MoxR-like ATPases [General function prediction only]; Region: COG0714
886293009231	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293009232	Walker A motif; other site
886293009233	ATP binding site [chemical binding]; other site
886293009234	Walker B motif; other site
886293009235	arginine finger; other site
886293009236	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
886293009237	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293009238	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293009239	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
886293009240	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
886293009241	PQQ-like domain; Region: PQQ_2; pfam13360
886293009242	Trp docking motif [polypeptide binding]; other site
886293009243	active site
886293009244	PQQ-like domain; Region: PQQ_2; pfam13360
886293009245	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293009246	non-specific DNA binding site [nucleotide binding]; other site
886293009247	salt bridge; other site
886293009248	sequence-specific DNA binding site [nucleotide binding]; other site
886293009249	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
886293009250	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
886293009251	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
886293009252	generic binding surface II; other site
886293009253	generic binding surface I; other site
886293009254	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293009255	Coenzyme A binding pocket [chemical binding]; other site
886293009256	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293009257	prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294
886293009258	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
886293009259	active site
886293009260	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
886293009261	ADP-ribose binding site [chemical binding]; other site
886293009262	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
886293009263	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
886293009264	putative active site [active]
886293009265	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
886293009266	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293009267	active site
886293009268	Methyltransferase domain; Region: Methyltransf_23; pfam13489
886293009269	Methyltransferase domain; Region: Methyltransf_11; pfam08241
886293009270	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
886293009271	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293009272	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293009273	active site
886293009274	ATP binding site [chemical binding]; other site
886293009275	substrate binding site [chemical binding]; other site
886293009276	activation loop (A-loop); other site
886293009277	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
886293009278	TPR motif; other site
886293009279	binding surface
886293009280	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293009281	TPR motif; other site
886293009282	TPR repeat; Region: TPR_11; pfam13414
886293009283	binding surface
886293009284	TPR repeat; Region: TPR_11; pfam13414
886293009285	TPR repeat; Region: TPR_11; pfam13414
886293009286	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293009287	binding surface
886293009288	TPR motif; other site
886293009289	TPR repeat; Region: TPR_11; pfam13414
886293009290	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293009291	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293009292	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
886293009293	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
886293009294	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
886293009295	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293009296	Calx-beta domain; Region: Calx-beta; pfam03160
886293009297	Calx-beta domain; Region: Calx-beta; pfam03160
886293009298	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293009299	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293009300	active site
886293009301	ATP binding site [chemical binding]; other site
886293009302	substrate binding site [chemical binding]; other site
886293009303	activation loop (A-loop); other site
886293009304	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
886293009305	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293009306	TPR motif; other site
886293009307	binding surface
886293009308	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293009309	binding surface
886293009310	TPR motif; other site
886293009311	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
886293009312	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293009313	TPR motif; other site
886293009314	binding surface
886293009315	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293009316	binding surface
886293009317	TPR motif; other site
886293009318	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293009319	binding surface
886293009320	TPR motif; other site
886293009321	TPR repeat; Region: TPR_11; pfam13414
886293009322	RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6
886293009323	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
886293009324	Cupin domain; Region: Cupin_2; cl17218
886293009325	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293009326	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
886293009327	NAD(P) binding site [chemical binding]; other site
886293009328	active site
886293009329	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
886293009330	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
886293009331	ligand binding site [chemical binding]; other site
886293009332	flexible hinge region; other site
886293009333	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
886293009334	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
886293009335	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
886293009336	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
886293009337	Right handed beta helix region; Region: Beta_helix; pfam13229
886293009338	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293009339	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293009340	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293009341	DNA binding residues [nucleotide binding]
886293009342	SnoaL-like domain; Region: SnoaL_2; pfam12680
886293009343	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
886293009344	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
886293009345	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
886293009346	dimerization interface [polypeptide binding]; other site
886293009347	DPS ferroxidase diiron center [ion binding]; other site
886293009348	ion pore; other site
886293009349	RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6
886293009350	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293009351	DNA binding residues [nucleotide binding]
886293009352	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293009353	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293009354	active site
886293009355	ATP binding site [chemical binding]; other site
886293009356	substrate binding site [chemical binding]; other site
886293009357	activation loop (A-loop); other site
886293009358	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
886293009359	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293009360	Coenzyme A binding pocket [chemical binding]; other site
886293009361	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
886293009362	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
886293009363	Active Sites [active]
886293009364	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
886293009365	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
886293009366	CysD dimerization site [polypeptide binding]; other site
886293009367	G1 box; other site
886293009368	putative GEF interaction site [polypeptide binding]; other site
886293009369	GTP/Mg2+ binding site [chemical binding]; other site
886293009370	Switch I region; other site
886293009371	G2 box; other site
886293009372	G3 box; other site
886293009373	Switch II region; other site
886293009374	G4 box; other site
886293009375	G5 box; other site
886293009376	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
886293009377	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
886293009378	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
886293009379	ligand-binding site [chemical binding]; other site
886293009380	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293009381	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
886293009382	active site flap/lid [active]
886293009383	nucleophilic elbow; other site
886293009384	catalytic triad [active]
886293009385	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
886293009386	active site
886293009387	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293009388	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
886293009389	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293009390	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
886293009391	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
886293009392	oxidoreductase; Provisional; Region: PRK06196
886293009393	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
886293009394	putative NAD(P) binding site [chemical binding]; other site
886293009395	active site
886293009396	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
886293009397	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
886293009398	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
886293009399	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
886293009400	homotetramer interface [polypeptide binding]; other site
886293009401	ligand binding site [chemical binding]; other site
886293009402	catalytic site [active]
886293009403	NAD binding site [chemical binding]; other site
886293009404	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
886293009405	Beta-lactamase; Region: Beta-lactamase; pfam00144
886293009406	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293009407	Walker A/P-loop; other site
886293009408	ATP binding site [chemical binding]; other site
886293009409	Q-loop/lid; other site
886293009410	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
886293009411	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
886293009412	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293009413	Walker A/P-loop; other site
886293009414	ATP binding site [chemical binding]; other site
886293009415	Q-loop/lid; other site
886293009416	ABC transporter signature motif; other site
886293009417	Walker B; other site
886293009418	D-loop; other site
886293009419	H-loop/switch region; other site
886293009420	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
886293009421	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293009422	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
886293009423	DNA binding residues [nucleotide binding]
886293009424	YCII-related domain; Region: YCII; cl00999
886293009425	Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802
886293009426	putative active site [active]
886293009427	YdjC motif; other site
886293009428	Mg binding site [ion binding]; other site
886293009429	homodimer interface [polypeptide binding]; other site
886293009430	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
886293009431	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293009432	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
886293009433	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
886293009434	putative active site [active]
886293009435	homotetrameric interface [polypeptide binding]; other site
886293009436	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
886293009437	Transcriptional regulator [Transcription]; Region: LysR; COG0583
886293009438	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
886293009439	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
886293009440	putative dimerization interface [polypeptide binding]; other site
886293009441	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
886293009442	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
886293009443	active site
886293009444	metal binding site [ion binding]; metal-binding site
886293009445	homotetramer interface [polypeptide binding]; other site
886293009446	TIGR03118 family protein; Region: PEPCTERM_chp_1
886293009447	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
886293009448	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293009449	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
886293009450	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
886293009451	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
886293009452	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
886293009453	Zn2+ binding site [ion binding]; other site
886293009454	Mg2+ binding site [ion binding]; other site
886293009455	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
886293009456	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
886293009457	conserved cys residue [active]
886293009458	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293009459	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
886293009460	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
886293009461	putative active site [active]
886293009462	putative metal binding site [ion binding]; other site
886293009463	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293009464	S-adenosylmethionine binding site [chemical binding]; other site
886293009465	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
886293009466	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
886293009467	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
886293009468	catalytic residue [active]
886293009469	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666
886293009470	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
886293009471	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
886293009472	Predicted transcriptional regulators [Transcription]; Region: COG1695
886293009473	Transcriptional regulator PadR-like family; Region: PadR; cl17335
886293009474	Clp amino terminal domain; Region: Clp_N; pfam02861
886293009475	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
886293009476	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
886293009477	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
886293009478	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
886293009479	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
886293009480	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
886293009481	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
886293009482	Domain of unknown function (DU1801); Region: DUF1801; cl17490
886293009483	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
886293009484	conserved cys residue [active]
886293009485	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
886293009486	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
886293009487	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
886293009488	agmatinase; Region: agmatinase; TIGR01230
886293009489	oligomer interface [polypeptide binding]; other site
886293009490	putative active site [active]
886293009491	Mn binding site [ion binding]; other site
886293009492	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
886293009493	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
886293009494	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
886293009495	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
886293009496	classical (c) SDRs; Region: SDR_c; cd05233
886293009497	NAD(P) binding site [chemical binding]; other site
886293009498	active site
886293009499	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
886293009500	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293009501	NAD(P) binding site [chemical binding]; other site
886293009502	active site
886293009503	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
886293009504	cyclase homology domain; Region: CHD; cd07302
886293009505	nucleotidyl binding site; other site
886293009506	metal binding site [ion binding]; metal-binding site
886293009507	dimer interface [polypeptide binding]; other site
886293009508	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293009509	active site
886293009510	ATP binding site [chemical binding]; other site
886293009511	substrate binding site [chemical binding]; other site
886293009512	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293009513	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293009514	substrate binding site [chemical binding]; other site
886293009515	activation loop (A-loop); other site
886293009516	activation loop (A-loop); other site
886293009517	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293009518	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293009519	structural tetrad; other site
886293009520	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293009521	structural tetrad; other site
886293009522	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
886293009523	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293009524	DNA binding residues [nucleotide binding]
886293009525	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
886293009526	Ca2+ binding site [ion binding]; other site
886293009527	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
886293009528	Ca2+ binding site [ion binding]; other site
886293009529	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
886293009530	Ca2+ binding site [ion binding]; other site
886293009531	Cna protein B-type domain; Region: Cna_B; pfam05738
886293009532	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293009533	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293009534	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293009535	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
886293009536	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
886293009537	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
886293009538	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293009539	maltose O-acetyltransferase; Provisional; Region: PRK10092
886293009540	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
886293009541	trimer interface [polypeptide binding]; other site
886293009542	active site
886293009543	substrate binding site [chemical binding]; other site
886293009544	CoA binding site [chemical binding]; other site
886293009545	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
886293009546	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
886293009547	substrate binding site [chemical binding]; other site
886293009548	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
886293009549	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
886293009550	putative dimer interface [polypeptide binding]; other site
886293009551	Tetratricopeptide repeat; Region: TPR_16; pfam13432
886293009552	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293009553	TPR motif; other site
886293009554	binding surface
886293009555	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293009556	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293009557	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293009558	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293009559	Sel1-like repeats; Region: SEL1; smart00671
886293009560	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
886293009561	Sel1-like repeats; Region: SEL1; smart00671
886293009562	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
886293009563	Right handed beta helix region; Region: Beta_helix; pfam13229
886293009564	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
886293009565	Phage capsid family; Region: Phage_capsid; pfam05065
886293009566	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
886293009567	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
886293009568	Phage portal protein; Region: Phage_portal; pfam04860
886293009569	cell division protein DamX; Validated; Region: PRK10905
886293009570	Phage terminase large subunit; Region: Terminase_3; cl12054
886293009571	TIGR04255 family protein; Region: sporadTIGR04255
886293009572	TIGR04255 family protein; Region: sporadTIGR04255
886293009573	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298
886293009574	active site
886293009575	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
886293009576	DNA-binding interface [nucleotide binding]; DNA binding site
886293009577	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293009578	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293009579	DNA binding residues [nucleotide binding]
886293009580	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
886293009581	polymerase nucleotide-binding site; other site
886293009582	DNA-binding residues [nucleotide binding]; DNA binding site
886293009583	nucleotide binding site [chemical binding]; other site
886293009584	primase nucleotide-binding site [nucleotide binding]; other site
886293009585	D5 N terminal like; Region: D5_N; smart00885
886293009586	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
886293009587	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
886293009588	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
886293009589	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293009590	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293009591	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293009592	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
886293009593	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
886293009594	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
886293009595	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
886293009596	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
886293009597	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
886293009598	Homeodomain-like domain; Region: HTH_23; cl17451
886293009599	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
886293009600	Uncharacterized conserved protein [Function unknown]; Region: COG5361
886293009601	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
886293009602	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293009603	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
886293009604	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
886293009605	active site
886293009606	Zn binding site [ion binding]; other site
886293009607	Methyltransferase domain; Region: Methyltransf_23; pfam13489
886293009608	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293009609	S-adenosylmethionine binding site [chemical binding]; other site
886293009610	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293009611	non-specific DNA binding site [nucleotide binding]; other site
886293009612	salt bridge; other site
886293009613	sequence-specific DNA binding site [nucleotide binding]; other site
886293009614	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
886293009615	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
886293009616	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
886293009617	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
886293009618	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
886293009619	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
886293009620	SPRY domain; Region: SPRY; cl02614
886293009621	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
886293009622	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
886293009623	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293009624	Coenzyme A binding pocket [chemical binding]; other site
886293009625	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
886293009626	Beta-lactamase; Region: Beta-lactamase; pfam00144
886293009627	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
886293009628	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
886293009629	Beta-lactamase; Region: Beta-lactamase; pfam00144
886293009630	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
886293009631	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293009632	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293009633	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293009634	DNA binding residues [nucleotide binding]
886293009635	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
886293009636	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293009637	Patatin-like phospholipase; Region: Patatin; pfam01734
886293009638	Caspase domain; Region: Peptidase_C14; pfam00656
886293009639	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293009640	protein binding site [polypeptide binding]; other site
886293009641	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293009642	protein binding site [polypeptide binding]; other site
886293009643	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844
886293009644	active site
886293009645	catalytic triad [active]
886293009646	oxyanion hole [active]
886293009647	G8 domain; Region: G8; pfam10162
886293009648	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293009649	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
886293009650	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
886293009651	ATP binding site [chemical binding]; other site
886293009652	Mg2+ binding site [ion binding]; other site
886293009653	G-X-G motif; other site
886293009654	Domain of unknown function (DUF4325); Region: DUF4325; pfam14213
886293009655	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
886293009656	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
886293009657	active site
886293009658	catalytic tetrad [active]
886293009659	putative active site [active]
886293009660	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
886293009661	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
886293009662	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
886293009663	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293009664	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293009665	DNA binding residues [nucleotide binding]
886293009666	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
886293009667	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
886293009668	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
886293009669	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
886293009670	homodimer interface [polypeptide binding]; other site
886293009671	active site
886293009672	TDP-binding site; other site
886293009673	acceptor substrate-binding pocket; other site
886293009674	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
886293009675	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
886293009676	PAS fold; Region: PAS_4; pfam08448
886293009677	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293009678	putative active site [active]
886293009679	heme pocket [chemical binding]; other site
886293009680	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
886293009681	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293009682	dimer interface [polypeptide binding]; other site
886293009683	phosphorylation site [posttranslational modification]
886293009684	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293009685	ATP binding site [chemical binding]; other site
886293009686	Mg2+ binding site [ion binding]; other site
886293009687	G-X-G motif; other site
886293009688	Methyltransferase domain; Region: Methyltransf_23; pfam13489
886293009689	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293009690	S-adenosylmethionine binding site [chemical binding]; other site
886293009691	Probable zinc-binding domain; Region: zf-trcl; pfam13451
886293009692	Predicted transcriptional regulators [Transcription]; Region: COG1733
886293009693	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
886293009694	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
886293009695	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
886293009696	NAD(P) binding site [chemical binding]; other site
886293009697	active site
886293009698	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293009699	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
886293009700	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
886293009701	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
886293009702	putative NAD(P) binding site [chemical binding]; other site
886293009703	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
886293009704	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
886293009705	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
886293009706	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
886293009707	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
886293009708	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
886293009709	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
886293009710	active site
886293009711	Domain of unknown function (DUF362); Region: DUF362; pfam04015
886293009712	agmatinase; Region: agmatinase; TIGR01230
886293009713	Agmatinase-like family; Region: Agmatinase-like; cd09990
886293009714	active site
886293009715	oligomer interface [polypeptide binding]; other site
886293009716	Mn binding site [ion binding]; other site
886293009717	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
886293009718	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
886293009719	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
886293009720	tetramer interface [polypeptide binding]; other site
886293009721	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293009722	catalytic residue [active]
886293009723	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
886293009724	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
886293009725	RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643
886293009726	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293009727	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293009728	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293009729	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
886293009730	Beta-lactamase; Region: Beta-lactamase; pfam00144
886293009731	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
886293009732	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
886293009733	Penicillinase repressor; Region: Pencillinase_R; pfam03965
886293009734	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
886293009735	HEAT repeats; Region: HEAT_2; pfam13646
886293009736	HEAT repeats; Region: HEAT_2; pfam13646
886293009737	Low molecular weight phosphatase family; Region: LMWPc; cl00105
886293009738	active site
886293009739	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
886293009740	arsenical-resistance protein; Region: acr3; TIGR00832
886293009741	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293009742	dimerization interface [polypeptide binding]; other site
886293009743	putative DNA binding site [nucleotide binding]; other site
886293009744	putative Zn2+ binding site [ion binding]; other site
886293009745	Ribosomal protein L37e; Region: Ribosomal_L37e; cl00932
886293009746	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
886293009747	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293009748	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
886293009749	Fic family protein [Function unknown]; Region: COG3177
886293009750	Fic/DOC family; Region: Fic; pfam02661
886293009751	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
886293009752	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
886293009753	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
886293009754	Methyltransferase domain; Region: Methyltransf_26; pfam13659
886293009755	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
886293009756	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
886293009757	SNF2 Helicase protein; Region: DUF3670; pfam12419
886293009758	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
886293009759	ATP binding site [chemical binding]; other site
886293009760	putative Mg++ binding site [ion binding]; other site
886293009761	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293009762	nucleotide binding region [chemical binding]; other site
886293009763	ATP-binding site [chemical binding]; other site
886293009764	Uncharacterized conserved protein [Function unknown]; Region: COG4279
886293009765	SWIM zinc finger; Region: SWIM; pfam04434
886293009766	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
886293009767	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
886293009768	Walker A/P-loop; other site
886293009769	ATP binding site [chemical binding]; other site
886293009770	Q-loop/lid; other site
886293009771	ABC transporter signature motif; other site
886293009772	Walker B; other site
886293009773	D-loop; other site
886293009774	H-loop/switch region; other site
886293009775	Protein of unknown function (DUF1444); Region: DUF1444; cl02011
886293009776	AAA ATPase domain; Region: AAA_16; pfam13191
886293009777	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293009778	dimerization interface [polypeptide binding]; other site
886293009779	putative Zn2+ binding site [ion binding]; other site
886293009780	putative DNA binding site [nucleotide binding]; other site
886293009781	TPR repeat; Region: TPR_11; pfam13414
886293009782	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293009783	TPR motif; other site
886293009784	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
886293009785	Beta-lactamase; Region: Beta-lactamase; pfam00144
886293009786	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
886293009787	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
886293009788	putative active site [active]
886293009789	putative NTP binding site [chemical binding]; other site
886293009790	putative nucleic acid binding site [nucleotide binding]; other site
886293009791	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
886293009792	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
886293009793	FtsX-like permease family; Region: FtsX; pfam02687
886293009794	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
886293009795	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
886293009796	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
886293009797	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
886293009798	NAD binding site [chemical binding]; other site
886293009799	homodimer interface [polypeptide binding]; other site
886293009800	active site
886293009801	substrate binding site [chemical binding]; other site
886293009802	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
886293009803	active site
886293009804	ATP binding site [chemical binding]; other site
886293009805	Phosphotransferase enzyme family; Region: APH; pfam01636
886293009806	substrate binding site [chemical binding]; other site
886293009807	YdjC-like protein; Region: YdjC; pfam04794
886293009808	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
886293009809	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
886293009810	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
886293009811	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
886293009812	Probable Catalytic site; other site
886293009813	metal-binding site
886293009814	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
886293009815	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
886293009816	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
886293009817	Probable Catalytic site; other site
886293009818	metal-binding site
886293009819	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
886293009820	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
886293009821	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
886293009822	Walker A/P-loop; other site
886293009823	ATP binding site [chemical binding]; other site
886293009824	Q-loop/lid; other site
886293009825	ABC transporter signature motif; other site
886293009826	Walker B; other site
886293009827	D-loop; other site
886293009828	H-loop/switch region; other site
886293009829	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
886293009830	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
886293009831	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293009832	active site
886293009833	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293009834	Uncharacterized conserved protein [Function unknown]; Region: COG1262
886293009835	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
886293009836	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293009837	structural tetrad; other site
886293009838	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293009839	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293009840	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
886293009841	Right handed beta helix region; Region: Beta_helix; pfam13229
886293009842	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293009843	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
886293009844	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293009845	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293009846	extended (e) SDRs; Region: SDR_e; cd08946
886293009847	NAD(P) binding site [chemical binding]; other site
886293009848	active site
886293009849	substrate binding site [chemical binding]; other site
886293009850	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
886293009851	substrate binding site [chemical binding]; other site
886293009852	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712
886293009853	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
886293009854	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
886293009855	NADP binding site [chemical binding]; other site
886293009856	active site
886293009857	putative substrate binding site [chemical binding]; other site
886293009858	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
886293009859	dimer interface [polypeptide binding]; other site
886293009860	substrate binding site [chemical binding]; other site
886293009861	metal binding sites [ion binding]; metal-binding site
886293009862	SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320
886293009863	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293009864	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293009865	active site
886293009866	ATP binding site [chemical binding]; other site
886293009867	substrate binding site [chemical binding]; other site
886293009868	activation loop (A-loop); other site
886293009869	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293009870	binding surface
886293009871	Tetratricopeptide repeat; Region: TPR_16; pfam13432
886293009872	TPR motif; other site
886293009873	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293009874	TPR motif; other site
886293009875	binding surface
886293009876	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293009877	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293009878	DNA binding residues [nucleotide binding]
886293009879	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
886293009880	Isochorismatase family; Region: Isochorismatase; pfam00857
886293009881	catalytic triad [active]
886293009882	dimer interface [polypeptide binding]; other site
886293009883	conserved cis-peptide bond; other site
886293009884	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
886293009885	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
886293009886	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
886293009887	active site
886293009888	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
886293009889	Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789
886293009890	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
886293009891	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
886293009892	FMN binding site [chemical binding]; other site
886293009893	active site
886293009894	substrate binding site [chemical binding]; other site
886293009895	catalytic residue [active]
886293009896	short chain dehydrogenase; Provisional; Region: PRK06172
886293009897	classical (c) SDRs; Region: SDR_c; cd05233
886293009898	NAD(P) binding site [chemical binding]; other site
886293009899	active site
886293009900	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
886293009901	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293009902	active site
886293009903	phosphorylation site [posttranslational modification]
886293009904	intermolecular recognition site; other site
886293009905	dimerization interface [polypeptide binding]; other site
886293009906	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
886293009907	DNA binding site [nucleotide binding]
886293009908	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
886293009909	dimerization interface [polypeptide binding]; other site
886293009910	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293009911	dimer interface [polypeptide binding]; other site
886293009912	phosphorylation site [posttranslational modification]
886293009913	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293009914	ATP binding site [chemical binding]; other site
886293009915	Mg2+ binding site [ion binding]; other site
886293009916	G-X-G motif; other site
886293009917	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
886293009918	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
886293009919	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
886293009920	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293009921	non-specific DNA binding site [nucleotide binding]; other site
886293009922	salt bridge; other site
886293009923	sequence-specific DNA binding site [nucleotide binding]; other site
886293009924	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
886293009925	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293009926	NAD(P) binding site [chemical binding]; other site
886293009927	active site
886293009928	Putative phosphatase (DUF442); Region: DUF442; cl17385
886293009929	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
886293009930	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293009931	PAS domain; Region: PAS_9; pfam13426
886293009932	putative active site [active]
886293009933	heme pocket [chemical binding]; other site
886293009934	PAS domain S-box; Region: sensory_box; TIGR00229
886293009935	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293009936	putative active site [active]
886293009937	heme pocket [chemical binding]; other site
886293009938	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
886293009939	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
886293009940	PAS fold; Region: PAS_4; pfam08448
886293009941	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293009942	putative active site [active]
886293009943	heme pocket [chemical binding]; other site
886293009944	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
886293009945	GAF domain; Region: GAF; pfam01590
886293009946	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
886293009947	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293009948	putative active site [active]
886293009949	heme pocket [chemical binding]; other site
886293009950	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293009951	dimer interface [polypeptide binding]; other site
886293009952	phosphorylation site [posttranslational modification]
886293009953	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293009954	ATP binding site [chemical binding]; other site
886293009955	Mg2+ binding site [ion binding]; other site
886293009956	G-X-G motif; other site
886293009957	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293009958	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293009959	active site
886293009960	phosphorylation site [posttranslational modification]
886293009961	intermolecular recognition site; other site
886293009962	dimerization interface [polypeptide binding]; other site
886293009963	repeat-companion domain TIGR02996; Region: rpt_mate_G_obs
886293009964	Leucine rich repeat; Region: LRR_8; pfam13855
886293009965	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
886293009966	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
886293009967	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293009968	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293009969	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293009970	DNA binding residues [nucleotide binding]
886293009971	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293009972	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293009973	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293009974	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293009975	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293009976	DNA binding residues [nucleotide binding]
886293009977	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
886293009978	IHF - DNA interface [nucleotide binding]; other site
886293009979	IHF dimer interface [polypeptide binding]; other site
886293009980	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
886293009981	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
886293009982	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293009983	Walker A motif; other site
886293009984	ATP binding site [chemical binding]; other site
886293009985	Walker B motif; other site
886293009986	arginine finger; other site
886293009987	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
886293009988	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
886293009989	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
886293009990	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
886293009991	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
886293009992	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
886293009993	active site
886293009994	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
886293009995	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293009996	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293009997	structural tetrad; other site
886293009998	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293009999	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293010000	structural tetrad; other site
886293010001	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293010002	Family description; Region: VCBS; pfam13517
886293010003	Family description; Region: VCBS; pfam13517
886293010004	Family description; Region: VCBS; pfam13517
886293010005	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
886293010006	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
886293010007	RHS Repeat; Region: RHS_repeat; pfam05593
886293010008	RHS Repeat; Region: RHS_repeat; pfam05593
886293010009	RHS Repeat; Region: RHS_repeat; pfam05593
886293010010	RHS Repeat; Region: RHS_repeat; pfam05593
886293010011	RHS Repeat; Region: RHS_repeat; pfam05593
886293010012	RHS Repeat; Region: RHS_repeat; pfam05593
886293010013	RHS Repeat; Region: RHS_repeat; pfam05593
886293010014	RHS Repeat; Region: RHS_repeat; pfam05593
886293010015	RHS Repeat; Region: RHS_repeat; pfam05593
886293010016	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
886293010017	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
886293010018	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
886293010019	active site
886293010020	TDP-binding site; other site
886293010021	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
886293010022	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
886293010023	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
886293010024	putative molybdopterin cofactor binding site [chemical binding]; other site
886293010025	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
886293010026	putative molybdopterin cofactor binding site; other site
886293010027	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293010028	Acylphosphatase; Region: Acylphosphatase; pfam00708
886293010029	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
886293010030	HypF finger; Region: zf-HYPF; pfam07503
886293010031	HypF finger; Region: zf-HYPF; pfam07503
886293010032	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
886293010033	HupF/HypC family; Region: HupF_HypC; pfam01455
886293010034	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
886293010035	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
886293010036	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
886293010037	dimerization interface [polypeptide binding]; other site
886293010038	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
886293010039	ATP binding site [chemical binding]; other site
886293010040	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
886293010041	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
886293010042	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
886293010043	NifU-like domain; Region: NifU; cl00484
886293010044	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
886293010045	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
886293010046	nickel binding site [ion binding]; other site
886293010047	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
886293010048	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
886293010049	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
886293010050	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
886293010051	minor groove reading motif; other site
886293010052	helix-hairpin-helix signature motif; other site
886293010053	active site
886293010054	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
886293010055	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
886293010056	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
886293010057	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
886293010058	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
886293010059	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
886293010060	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
886293010061	active site
886293010062	catalytic triad [active]
886293010063	oxyanion hole [active]
886293010064	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293010065	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293010066	Cytochrome c; Region: Cytochrom_C; pfam00034
886293010067	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293010068	AAA domain; Region: AAA_27; pfam13514
886293010069	Walker A/P-loop; other site
886293010070	ATP binding site [chemical binding]; other site
886293010071	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
886293010072	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
886293010073	active site
886293010074	metal binding site [ion binding]; metal-binding site
886293010075	DNA binding site [nucleotide binding]
886293010076	AAA domain; Region: AAA_30; pfam13604
886293010077	Family description; Region: UvrD_C_2; pfam13538
886293010078	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
886293010079	Part of AAA domain; Region: AAA_19; pfam13245
886293010080	Family description; Region: UvrD_C_2; pfam13538
886293010081	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
886293010082	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
886293010083	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
886293010084	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
886293010085	putative active site [active]
886293010086	MgtC family; Region: MgtC; pfam02308
886293010087	Predicted membrane protein [Function unknown]; Region: COG3174
886293010088	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
886293010089	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293010090	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293010091	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
886293010092	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
886293010093	putative active site [active]
886293010094	putative NTP binding site [chemical binding]; other site
886293010095	putative nucleic acid binding site [nucleotide binding]; other site
886293010096	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
886293010097	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
886293010098	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
886293010099	active site
886293010100	Phage capsid family; Region: Phage_capsid; pfam05065
886293010101	Helix-turn-helix domain; Region: HTH_17; cl17695
886293010102	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
886293010103	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293010104	non-specific DNA binding site [nucleotide binding]; other site
886293010105	salt bridge; other site
886293010106	sequence-specific DNA binding site [nucleotide binding]; other site
886293010107	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
886293010108	AAA domain; Region: AAA_25; pfam13481
886293010109	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
886293010110	Walker A motif; other site
886293010111	ATP binding site [chemical binding]; other site
886293010112	Walker B motif; other site
886293010113	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
886293010114	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
886293010115	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
886293010116	active site
886293010117	DNA binding site [nucleotide binding]
886293010118	Int/Topo IB signature motif; other site
886293010119	UvrB/uvrC motif; Region: UVR; pfam02151
886293010120	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
886293010121	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
886293010122	FAD binding pocket [chemical binding]; other site
886293010123	FAD binding motif [chemical binding]; other site
886293010124	phosphate binding motif [ion binding]; other site
886293010125	beta-alpha-beta structure motif; other site
886293010126	NAD binding pocket [chemical binding]; other site
886293010127	Iron coordination center [ion binding]; other site
886293010128	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
886293010129	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293010130	Coenzyme A binding pocket [chemical binding]; other site
886293010131	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
886293010132	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293010133	catalytic triad [active]
886293010134	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293010135	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293010136	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
886293010137	DNA binding residues [nucleotide binding]
886293010138	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
886293010139	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
886293010140	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293010141	S-adenosylmethionine binding site [chemical binding]; other site
886293010142	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
886293010143	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
886293010144	active site 1 [active]
886293010145	dimer interface [polypeptide binding]; other site
886293010146	hexamer interface [polypeptide binding]; other site
886293010147	active site 2 [active]
886293010148	GAF domain; Region: GAF; pfam01590
886293010149	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
886293010150	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
886293010151	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
886293010152	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
886293010153	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293010154	motif II; other site
886293010155	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
886293010156	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293010157	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
886293010158	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293010159	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
886293010160	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293010161	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
886293010162	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
886293010163	Walker A/P-loop; other site
886293010164	ATP binding site [chemical binding]; other site
886293010165	Q-loop/lid; other site
886293010166	ABC transporter signature motif; other site
886293010167	Walker B; other site
886293010168	D-loop; other site
886293010169	H-loop/switch region; other site
886293010170	Nuclease-related domain; Region: NERD; pfam08378
886293010171	UV-endonuclease UvdE; Region: UvdE; cl10036
886293010172	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293010173	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293010174	protein binding site [polypeptide binding]; other site
886293010175	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293010176	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293010177	Sulfatase; Region: Sulfatase; pfam00884
886293010178	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293010179	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293010180	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
886293010181	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293010182	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
886293010183	Domain of unknown function (DUF2382); Region: DUF2382; cl01590
886293010184	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293010185	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293010186	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293010187	Haem-binding domain; Region: Haem_bd; pfam14376
886293010188	Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712
886293010189	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
886293010190	EF-hand domain pair; Region: EF_hand_5; pfam13499
886293010191	Ca2+ binding site [ion binding]; other site
886293010192	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
886293010193	homodimer interface [polypeptide binding]; other site
886293010194	homotetramer interface [polypeptide binding]; other site
886293010195	active site pocket [active]
886293010196	cleavage site
886293010197	Right handed beta helix region; Region: Beta_helix; pfam13229
886293010198	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
886293010199	Methyltransferase domain; Region: Methyltransf_31; pfam13847
886293010200	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293010201	Low molecular weight phosphatase family; Region: LMWPc; cl00105
886293010202	active site
886293010203	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293010204	putative DNA binding site [nucleotide binding]; other site
886293010205	putative Zn2+ binding site [ion binding]; other site
886293010206	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
886293010207	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
886293010208	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
886293010209	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293010210	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
886293010211	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
886293010212	Cl- selectivity filter; other site
886293010213	Cl- binding residues [ion binding]; other site
886293010214	pore gating glutamate residue; other site
886293010215	dimer interface [polypeptide binding]; other site
886293010216	FOG: CBS domain [General function prediction only]; Region: COG0517
886293010217	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
886293010218	Methyltransferase domain; Region: Methyltransf_23; pfam13489
886293010219	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293010220	S-adenosylmethionine binding site [chemical binding]; other site
886293010221	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
886293010222	catalytic residues [active]
886293010223	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
886293010224	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
886293010225	Part of AAA domain; Region: AAA_19; pfam13245
886293010226	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
886293010227	AAA domain; Region: AAA_12; pfam13087
886293010228	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
886293010229	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293010230	Sulfatase; Region: Sulfatase; pfam00884
886293010231	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
886293010232	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
886293010233	substrate binding [chemical binding]; other site
886293010234	active site
886293010235	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
886293010236	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
886293010237	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
886293010238	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
886293010239	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
886293010240	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293010241	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293010242	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293010243	Family description; Region: VCBS; pfam13517
886293010244	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
886293010245	Beta-lactamase; Region: Beta-lactamase; pfam00144
886293010246	hypothetical protein; Provisional; Region: PRK12378
886293010247	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293010248	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293010249	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293010250	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
886293010251	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293010252	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293010253	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293010254	structural tetrad; other site
886293010255	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293010256	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293010257	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293010258	SET domain; Region: SET; pfam00856
886293010259	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293010260	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293010261	catalytic residues [active]
886293010262	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
886293010263	active site
886293010264	DNA binding site [nucleotide binding]
886293010265	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
886293010266	active site
886293010267	homotetramer interface [polypeptide binding]; other site
886293010268	urate oxidase; Region: urate_oxi; TIGR03383
886293010269	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
886293010270	active site
886293010271	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
886293010272	homotrimer interaction site [polypeptide binding]; other site
886293010273	putative active site [active]
886293010274	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293010275	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293010276	PcfJ-like protein; Region: PcfJ; pfam14284
886293010277	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
886293010278	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
886293010279	Na binding site [ion binding]; other site
886293010280	Protein of unknown function, DUF485; Region: DUF485; pfam04341
886293010281	Protein kinase domain; Region: Pkinase; pfam00069
886293010282	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293010283	substrate binding site [chemical binding]; other site
886293010284	activation loop (A-loop); other site
886293010285	BON domain; Region: BON; pfam04972
886293010286	NAD synthetase; Reviewed; Region: nadE; PRK02628
886293010287	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
886293010288	multimer interface [polypeptide binding]; other site
886293010289	active site
886293010290	catalytic triad [active]
886293010291	protein interface 1 [polypeptide binding]; other site
886293010292	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
886293010293	homodimer interface [polypeptide binding]; other site
886293010294	NAD binding pocket [chemical binding]; other site
886293010295	ATP binding pocket [chemical binding]; other site
886293010296	Mg binding site [ion binding]; other site
886293010297	active-site loop [active]
886293010298	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
886293010299	active site
886293010300	metal binding site [ion binding]; metal-binding site
886293010301	Small integral membrane protein [Function unknown]; Region: COG5487; cl17674
886293010302	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
886293010303	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
886293010304	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
886293010305	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
886293010306	active site
886293010307	TDP-binding site; other site
886293010308	acceptor substrate-binding pocket; other site
886293010309	homodimer interface [polypeptide binding]; other site
886293010310	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
886293010311	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
886293010312	active site
886293010313	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
886293010314	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
886293010315	ATP binding site [chemical binding]; other site
886293010316	putative Mg++ binding site [ion binding]; other site
886293010317	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293010318	nucleotide binding region [chemical binding]; other site
886293010319	ATP-binding site [chemical binding]; other site
886293010320	Yqey-like protein; Region: YqeY; cl17540
886293010321	Uncharacterized conserved protein [Function unknown]; Region: COG3391
886293010322	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
886293010323	active site
886293010324	Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722
886293010325	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
886293010326	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
886293010327	active site
886293010328	metal binding site [ion binding]; metal-binding site
886293010329	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
886293010330	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
886293010331	active site
886293010332	catalytic site [active]
886293010333	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
886293010334	PAS fold; Region: PAS_4; pfam08448
886293010335	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293010336	putative active site [active]
886293010337	heme pocket [chemical binding]; other site
886293010338	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
886293010339	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293010340	putative active site [active]
886293010341	heme pocket [chemical binding]; other site
886293010342	PAS domain; Region: PAS; smart00091
886293010343	putative active site [active]
886293010344	heme pocket [chemical binding]; other site
886293010345	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293010346	dimer interface [polypeptide binding]; other site
886293010347	phosphorylation site [posttranslational modification]
886293010348	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293010349	ATP binding site [chemical binding]; other site
886293010350	Mg2+ binding site [ion binding]; other site
886293010351	G-X-G motif; other site
886293010352	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
886293010353	Cna protein B-type domain; Region: Cna_B; pfam05738
886293010354	Cna protein B-type domain; Region: Cna_B; pfam05738
886293010355	Cna protein B-type domain; Region: Cna_B; pfam05738
886293010356	Cna protein B-type domain; Region: Cna_B; pfam05738
886293010357	Cna protein B-type domain; Region: Cna_B; pfam05738
886293010358	Cna protein B-type domain; Region: Cna_B; pfam05738
886293010359	Cna protein B-type domain; Region: Cna_B; pfam05738
886293010360	Cna protein B-type domain; Region: Cna_B; pfam05738
886293010361	exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178
886293010362	CAAX protease self-immunity; Region: Abi; cl00558
886293010363	Peptidase family M49; Region: Peptidase_M49; pfam03571
886293010364	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
886293010365	Putative glucoamylase; Region: Glycoamylase; pfam10091
886293010366	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
886293010367	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293010368	active site
886293010369	phosphorylation site [posttranslational modification]
886293010370	intermolecular recognition site; other site
886293010371	dimerization interface [polypeptide binding]; other site
886293010372	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293010373	Walker A motif; other site
886293010374	ATP binding site [chemical binding]; other site
886293010375	Walker B motif; other site
886293010376	arginine finger; other site
886293010377	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
886293010378	methionine sulfoxide reductase B; Provisional; Region: PRK00222
886293010379	SelR domain; Region: SelR; pfam01641
886293010380	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
886293010381	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
886293010382	TPR repeat; Region: TPR_11; pfam13414
886293010383	NYN domain; Region: NYN; pfam01936
886293010384	putative metal binding site [ion binding]; other site
886293010385	Uncharacterized conserved protein [Function unknown]; Region: COG1432
886293010386	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
886293010387	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
886293010388	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
886293010389	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293010390	binding surface
886293010391	TPR motif; other site
886293010392	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293010393	binding surface
886293010394	TPR motif; other site
886293010395	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
886293010396	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293010397	binding surface
886293010398	TPR motif; other site
886293010399	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
886293010400	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
886293010401	binding surface
886293010402	TPR motif; other site
886293010403	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
886293010404	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293010405	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
886293010406	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
886293010407	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
886293010408	metal ion-dependent adhesion site (MIDAS); other site
886293010409	SpoVR like protein; Region: SpoVR; pfam04293
886293010410	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
886293010411	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
886293010412	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
886293010413	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
886293010414	malate dehydrogenase; Provisional; Region: PRK13529
886293010415	Malic enzyme, N-terminal domain; Region: malic; pfam00390
886293010416	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
886293010417	NAD(P) binding site [chemical binding]; other site
886293010418	MarR family; Region: MarR_2; cl17246
886293010419	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
886293010420	YceI-like domain; Region: YceI; cl01001
886293010421	Protein of unknown function (DUF1290); Region: DUF1290; cl01587
886293010422	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
886293010423	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
886293010424	putative NAD(P) binding site [chemical binding]; other site
886293010425	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; Region: RpoD; COG0568
886293010426	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293010427	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293010428	DNA binding residues [nucleotide binding]
886293010429	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
886293010430	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
886293010431	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
886293010432	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
886293010433	ATP binding site [chemical binding]; other site
886293010434	putative Mg++ binding site [ion binding]; other site
886293010435	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293010436	nucleotide binding region [chemical binding]; other site
886293010437	ATP-binding site [chemical binding]; other site
886293010438	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
886293010439	Ligand Binding Site [chemical binding]; other site
886293010440	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
886293010441	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
886293010442	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
886293010443	Walker A/P-loop; other site
886293010444	ATP binding site [chemical binding]; other site
886293010445	Q-loop/lid; other site
886293010446	ABC transporter signature motif; other site
886293010447	Walker B; other site
886293010448	D-loop; other site
886293010449	H-loop/switch region; other site
886293010450	Homeodomain-like domain; Region: HTH_23; pfam13384
886293010451	Winged helix-turn helix; Region: HTH_29; pfam13551
886293010452	Homeodomain-like domain; Region: HTH_32; pfam13565
886293010453	DDE superfamily endonuclease; Region: DDE_3; pfam13358
886293010454	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
886293010455	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
886293010456	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
886293010457	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
886293010458	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
886293010459	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
886293010460	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
886293010461	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
886293010462	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
886293010463	active site
886293010464	catalytic triad [active]
886293010465	oxyanion hole [active]
886293010466	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
886293010467	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293010468	structural tetrad; other site
886293010469	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
886293010470	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
886293010471	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
886293010472	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
886293010473	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
886293010474	protein binding site [polypeptide binding]; other site
886293010475	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
886293010476	Domain interface; other site
886293010477	Peptide binding site; other site
886293010478	Active site tetrad [active]
886293010479	DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188
886293010480	Ligand binding site; other site
886293010481	Ligand binding site; other site
886293010482	Ligand binding site; other site
886293010483	Putative Catalytic site; other site
886293010484	DXD motif; other site
886293010485	Methyltransferase domain; Region: Methyltransf_31; pfam13847
886293010486	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293010487	S-adenosylmethionine binding site [chemical binding]; other site
886293010488	CHASE3 domain; Region: CHASE3; pfam05227
886293010489	PAS fold; Region: PAS_4; pfam08448
886293010490	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293010491	PAS fold; Region: PAS_3; pfam08447
886293010492	putative active site [active]
886293010493	heme pocket [chemical binding]; other site
886293010494	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
886293010495	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
886293010496	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
886293010497	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
886293010498	Zn2+ binding site [ion binding]; other site
886293010499	Mg2+ binding site [ion binding]; other site
886293010500	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293010501	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293010502	active site
886293010503	phosphorylation site [posttranslational modification]
886293010504	intermolecular recognition site; other site
886293010505	dimerization interface [polypeptide binding]; other site
886293010506	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
886293010507	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
886293010508	metal binding site [ion binding]; metal-binding site
886293010509	active site
886293010510	I-site; other site
886293010511	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293010512	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
886293010513	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
886293010514	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
886293010515	active site
886293010516	Zn binding site [ion binding]; other site
886293010517	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293010518	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
886293010519	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293010520	The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; Region: Luminal_IRE1_like; cl14874
886293010521	HEAT repeats; Region: HEAT_2; pfam13646
886293010522	Cytochrome c; Region: Cytochrom_C; cl11414
886293010523	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293010524	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
886293010525	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
886293010526	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
886293010527	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
886293010528	active site
886293010529	catalytic tetrad [active]
886293010530	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
886293010531	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
886293010532	tetrameric interface [polypeptide binding]; other site
886293010533	NAD binding site [chemical binding]; other site
886293010534	catalytic residues [active]
886293010535	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
886293010536	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
886293010537	active site
886293010538	catalytic tetrad [active]
886293010539	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
886293010540	active site 1 [active]
886293010541	dimer interface [polypeptide binding]; other site
886293010542	hexamer interface [polypeptide binding]; other site
886293010543	active site 2 [active]
886293010544	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
886293010545	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
886293010546	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
886293010547	DNA-binding site [nucleotide binding]; DNA binding site
886293010548	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
886293010549	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293010550	homodimer interface [polypeptide binding]; other site
886293010551	catalytic residue [active]
886293010552	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293010553	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
886293010554	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
886293010555	putative active site [active]
886293010556	catalytic site [active]
886293010557	putative metal binding site [ion binding]; other site
886293010558	oligomer interface [polypeptide binding]; other site
886293010559	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
886293010560	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
886293010561	putative active site [active]
886293010562	catalytic site [active]
886293010563	putative metal binding site [ion binding]; other site
886293010564	oligomer interface [polypeptide binding]; other site
886293010565	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; Region: RpoD; COG0568
886293010566	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293010567	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293010568	DNA binding residues [nucleotide binding]
886293010569	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
886293010570	putative ligand binding site [chemical binding]; other site
886293010571	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
886293010572	Beta-lactamase; Region: Beta-lactamase; pfam00144
886293010573	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293010574	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293010575	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
886293010576	Putative zinc-finger; Region: zf-HC2; pfam13490
886293010577	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293010578	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293010579	active site
886293010580	ATP binding site [chemical binding]; other site
886293010581	substrate binding site [chemical binding]; other site
886293010582	activation loop (A-loop); other site
886293010583	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
886293010584	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
886293010585	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
886293010586	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
886293010587	NAD binding site [chemical binding]; other site
886293010588	substrate binding site [chemical binding]; other site
886293010589	catalytic Zn binding site [ion binding]; other site
886293010590	tetramer interface [polypeptide binding]; other site
886293010591	structural Zn binding site [ion binding]; other site
886293010592	transposase; Provisional; Region: PRK06526
886293010593	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293010594	Walker A motif; other site
886293010595	ATP binding site [chemical binding]; other site
886293010596	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
886293010597	Integrase core domain; Region: rve; pfam00665
886293010598	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
886293010599	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
886293010600	catalytic residues [active]
886293010601	catalytic nucleophile [active]
886293010602	Recombinase; Region: Recombinase; pfam07508
886293010603	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
886293010604	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166
886293010605	Right handed beta helix region; Region: Beta_helix; pfam13229
886293010606	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010607	Interdomain contacts; other site
886293010608	Cytokine receptor motif; other site
886293010609	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010610	Interdomain contacts; other site
886293010611	Cytokine receptor motif; other site
886293010612	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010613	Interdomain contacts; other site
886293010614	Cytokine receptor motif; other site
886293010615	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010616	Interdomain contacts; other site
886293010617	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010618	Interdomain contacts; other site
886293010619	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010620	Interdomain contacts; other site
886293010621	Cytokine receptor motif; other site
886293010622	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010623	Interdomain contacts; other site
886293010624	Cytokine receptor motif; other site
886293010625	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010626	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010627	Interdomain contacts; other site
886293010628	Cytokine receptor motif; other site
886293010629	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010630	Interdomain contacts; other site
886293010631	Cytokine receptor motif; other site
886293010632	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010633	Interdomain contacts; other site
886293010634	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010635	Interdomain contacts; other site
886293010636	Cytokine receptor motif; other site
886293010637	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010638	Interdomain contacts; other site
886293010639	Cytokine receptor motif; other site
886293010640	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010641	Interdomain contacts; other site
886293010642	Cytokine receptor motif; other site
886293010643	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010644	Interdomain contacts; other site
886293010645	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010646	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010647	Interdomain contacts; other site
886293010648	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010649	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010650	Interdomain contacts; other site
886293010651	Cytokine receptor motif; other site
886293010652	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010653	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010654	Interdomain contacts; other site
886293010655	Cytokine receptor motif; other site
886293010656	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010657	Interdomain contacts; other site
886293010658	Cytokine receptor motif; other site
886293010659	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010660	Interdomain contacts; other site
886293010661	Cytokine receptor motif; other site
886293010662	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010663	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010664	Interdomain contacts; other site
886293010665	Cytokine receptor motif; other site
886293010666	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010667	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010668	Interdomain contacts; other site
886293010669	Cytokine receptor motif; other site
886293010670	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010671	Interdomain contacts; other site
886293010672	Cytokine receptor motif; other site
886293010673	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010674	Interdomain contacts; other site
886293010675	Cytokine receptor motif; other site
886293010676	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010677	Interdomain contacts; other site
886293010678	Cytokine receptor motif; other site
886293010679	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010680	Interdomain contacts; other site
886293010681	Cytokine receptor motif; other site
886293010682	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010683	Interdomain contacts; other site
886293010684	Cytokine receptor motif; other site
886293010685	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010686	Interdomain contacts; other site
886293010687	Cytokine receptor motif; other site
886293010688	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010689	Interdomain contacts; other site
886293010690	Cytokine receptor motif; other site
886293010691	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010692	Interdomain contacts; other site
886293010693	Cytokine receptor motif; other site
886293010694	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010695	Interdomain contacts; other site
886293010696	Cytokine receptor motif; other site
886293010697	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010698	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010699	Interdomain contacts; other site
886293010700	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010701	Interdomain contacts; other site
886293010702	Cytokine receptor motif; other site
886293010703	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010704	Interdomain contacts; other site
886293010705	Cytokine receptor motif; other site
886293010706	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010707	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010708	Interdomain contacts; other site
886293010709	Cytokine receptor motif; other site
886293010710	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010711	Interdomain contacts; other site
886293010712	Cytokine receptor motif; other site
886293010713	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010714	Cytokine receptor motif; other site
886293010715	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010716	Interdomain contacts; other site
886293010717	Cytokine receptor motif; other site
886293010718	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010719	Interdomain contacts; other site
886293010720	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010721	Interdomain contacts; other site
886293010722	Cytokine receptor motif; other site
886293010723	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010724	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010725	Interdomain contacts; other site
886293010726	Cytokine receptor motif; other site
886293010727	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010728	Interdomain contacts; other site
886293010729	Cytokine receptor motif; other site
886293010730	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010731	Interdomain contacts; other site
886293010732	Cytokine receptor motif; other site
886293010733	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010734	Interdomain contacts; other site
886293010735	Cytokine receptor motif; other site
886293010736	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293010737	Interdomain contacts; other site
886293010738	Cytokine receptor motif; other site
886293010739	VCBS repeat; Region: VCBS_repeat; TIGR01965
886293010740	VCBS repeat; Region: VCBS_repeat; TIGR01965
886293010741	A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414
886293010742	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
886293010743	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
886293010744	Transposase IS200 like; Region: Y1_Tnp; cl00848
886293010745	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
886293010746	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
886293010747	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
886293010748	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
886293010749	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
886293010750	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
886293010751	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293010752	salt bridge; other site
886293010753	non-specific DNA binding site [nucleotide binding]; other site
886293010754	sequence-specific DNA binding site [nucleotide binding]; other site
886293010755	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293010756	binding surface
886293010757	TPR motif; other site
886293010758	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293010759	binding surface
886293010760	TPR motif; other site
886293010761	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
886293010762	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293010763	binding surface
886293010764	TPR motif; other site
886293010765	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293010766	binding surface
886293010767	TPR motif; other site
886293010768	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293010769	binding surface
886293010770	Tetratricopeptide repeat; Region: TPR_16; pfam13432
886293010771	TPR motif; other site
886293010772	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
886293010773	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
886293010774	active site
886293010775	nucleotide binding site [chemical binding]; other site
886293010776	HIGH motif; other site
886293010777	KMSKS motif; other site
886293010778	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
886293010779	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
886293010780	thiamine phosphate binding site [chemical binding]; other site
886293010781	active site
886293010782	pyrophosphate binding site [ion binding]; other site
886293010783	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
886293010784	catalytic residues [active]
886293010785	dimer interface [polypeptide binding]; other site
886293010786	HlyD family secretion protein; Region: HlyD; pfam00529
886293010787	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293010788	Matrixin; Region: Peptidase_M10; pfam00413
886293010789	active site
886293010790	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
886293010791	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
886293010792	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
886293010793	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
886293010794	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
886293010795	active site
886293010796	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
886293010797	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
886293010798	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
886293010799	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
886293010800	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
886293010801	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
886293010802	FtsX-like permease family; Region: FtsX; pfam02687
886293010803	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
886293010804	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
886293010805	Walker A/P-loop; other site
886293010806	ATP binding site [chemical binding]; other site
886293010807	Q-loop/lid; other site
886293010808	ABC transporter signature motif; other site
886293010809	Walker B; other site
886293010810	D-loop; other site
886293010811	H-loop/switch region; other site
886293010812	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293010813	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293010814	Outer membrane efflux protein; Region: OEP; pfam02321
886293010815	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
886293010816	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
886293010817	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
886293010818	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
886293010819	dimer interface [polypeptide binding]; other site
886293010820	PYR/PP interface [polypeptide binding]; other site
886293010821	TPP binding site [chemical binding]; other site
886293010822	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
886293010823	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
886293010824	TPP-binding site [chemical binding]; other site
886293010825	dimer interface [polypeptide binding]; other site
886293010826	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
886293010827	putative active site pocket [active]
886293010828	dimerization interface [polypeptide binding]; other site
886293010829	putative catalytic residue [active]
886293010830	Bacterial Ig-like domain; Region: Big_5; pfam13205
886293010831	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
886293010832	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
886293010833	thymidylate kinase; Validated; Region: tmk; PRK00698
886293010834	TMP-binding site; other site
886293010835	ATP-binding site [chemical binding]; other site
886293010836	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293010837	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293010838	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293010839	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
886293010840	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312
886293010841	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293010842	putative DNA binding site [nucleotide binding]; other site
886293010843	dimerization interface [polypeptide binding]; other site
886293010844	putative Zn2+ binding site [ion binding]; other site
886293010845	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
886293010846	putative hydrophobic ligand binding site [chemical binding]; other site
886293010847	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
886293010848	nudix motif; other site
886293010849	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
886293010850	E3 interaction surface; other site
886293010851	lipoyl attachment site [posttranslational modification]; other site
886293010852	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
886293010853	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293010854	putative catalytic residue [active]
886293010855	Haem-binding domain; Region: Haem_bd; pfam14376
886293010856	Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712
886293010857	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
886293010858	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293010859	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
886293010860	Metal-binding active site; metal-binding site
886293010861	periplasmic protein; Provisional; Region: PRK10568
886293010862	BON domain; Region: BON; pfam04972
886293010863	threonine synthase; Validated; Region: PRK06260
886293010864	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
886293010865	homodimer interface [polypeptide binding]; other site
886293010866	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293010867	catalytic residue [active]
886293010868	Response regulator receiver domain; Region: Response_reg; pfam00072
886293010869	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293010870	active site
886293010871	phosphorylation site [posttranslational modification]
886293010872	intermolecular recognition site; other site
886293010873	dimerization interface [polypeptide binding]; other site
886293010874	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
886293010875	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
886293010876	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
886293010877	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293010878	active site
886293010879	phosphorylation site [posttranslational modification]
886293010880	intermolecular recognition site; other site
886293010881	CheB methylesterase; Region: CheB_methylest; pfam01339
886293010882	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
886293010883	putative binding surface; other site
886293010884	active site
886293010885	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
886293010886	putative binding surface; other site
886293010887	active site
886293010888	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
886293010889	putative binding surface; other site
886293010890	active site
886293010891	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
886293010892	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293010893	ATP binding site [chemical binding]; other site
886293010894	Mg2+ binding site [ion binding]; other site
886293010895	G-X-G motif; other site
886293010896	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
886293010897	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293010898	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293010899	active site
886293010900	phosphorylation site [posttranslational modification]
886293010901	intermolecular recognition site; other site
886293010902	dimerization interface [polypeptide binding]; other site
886293010903	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
886293010904	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
886293010905	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
886293010906	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293010907	TPR motif; other site
886293010908	TPR repeat; Region: TPR_11; pfam13414
886293010909	binding surface
886293010910	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
886293010911	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
886293010912	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
886293010913	dimer interface [polypeptide binding]; other site
886293010914	putative CheW interface [polypeptide binding]; other site
886293010915	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
886293010916	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
886293010917	putative ligand binding site [chemical binding]; other site
886293010918	dihydrodipicolinate reductase; Provisional; Region: PRK00048
886293010919	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
886293010920	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
886293010921	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293010922	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
886293010923	NAD binding site [chemical binding]; other site
886293010924	putative substrate binding site 2 [chemical binding]; other site
886293010925	putative substrate binding site 1 [chemical binding]; other site
886293010926	active site
886293010927	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293010928	binding surface
886293010929	Tetratricopeptide repeat; Region: TPR_16; pfam13432
886293010930	TPR motif; other site
886293010931	Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063
886293010932	Family description; Region: VCBS; pfam13517
886293010933	Family description; Region: VCBS; pfam13517
886293010934	Family description; Region: VCBS; pfam13517
886293010935	Family description; Region: VCBS; pfam13517
886293010936	Family description; Region: VCBS; pfam13517
886293010937	Family description; Region: VCBS; pfam13517
886293010938	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
886293010939	Family description; Region: VCBS; pfam13517
886293010940	Family description; Region: VCBS; pfam13517
886293010941	Family description; Region: VCBS; pfam13517
886293010942	Family description; Region: VCBS; pfam13517
886293010943	Family description; Region: VCBS; pfam13517
886293010944	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
886293010945	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293010946	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293010947	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293010948	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293010949	DNA binding residues [nucleotide binding]
886293010950	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
886293010951	Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050
886293010952	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293010953	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293010954	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293010955	catalytic residues [active]
886293010956	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
886293010957	active site
886293010958	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
886293010959	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
886293010960	P-loop; other site
886293010961	Magnesium ion binding site [ion binding]; other site
886293010962	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
886293010963	Magnesium ion binding site [ion binding]; other site
886293010964	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
886293010965	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
886293010966	Walker A/P-loop; other site
886293010967	ATP binding site [chemical binding]; other site
886293010968	Q-loop/lid; other site
886293010969	ABC transporter signature motif; other site
886293010970	Walker B; other site
886293010971	D-loop; other site
886293010972	H-loop/switch region; other site
886293010973	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
886293010974	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
886293010975	FtsX-like permease family; Region: FtsX; pfam02687
886293010976	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
886293010977	Protein of unknown function (DUF3299); Region: DUF3299; cl01387
886293010978	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
886293010979	Strictosidine synthase; Region: Str_synth; pfam03088
886293010980	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
886293010981	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
886293010982	endonuclease III; Region: ENDO3c; smart00478
886293010983	minor groove reading motif; other site
886293010984	helix-hairpin-helix signature motif; other site
886293010985	active site
886293010986	Domain of unknown function DUF11; Region: DUF11; cl17728
886293010987	RDD family; Region: RDD; pfam06271
886293010988	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293010989	Amidohydrolase; Region: Amidohydro_2; pfam04909
886293010990	active site
886293010991	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
886293010992	substrate binding site; other site
886293010993	dimer interface; other site
886293010994	Restriction endonuclease; Region: Mrr_cat; pfam04471
886293010995	phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313
886293010996	Flavoprotein; Region: Flavoprotein; pfam02441
886293010997	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
886293010998	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
886293010999	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
886293011000	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
886293011001	active site
886293011002	dimer interface [polypeptide binding]; other site
886293011003	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
886293011004	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
886293011005	active site
886293011006	FMN binding site [chemical binding]; other site
886293011007	substrate binding site [chemical binding]; other site
886293011008	3Fe-4S cluster binding site [ion binding]; other site
886293011009	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
886293011010	domain interface; other site
886293011011	Transcriptional regulator [Transcription]; Region: LysR; COG0583
886293011012	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
886293011013	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
886293011014	dimerization interface [polypeptide binding]; other site
886293011015	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
886293011016	EF-hand domain pair; Region: EF_hand_5; pfam13499
886293011017	Ca2+ binding site [ion binding]; other site
886293011018	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293011019	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293011020	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293011021	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293011022	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
886293011023	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
886293011024	RNA binding surface [nucleotide binding]; other site
886293011025	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
886293011026	active site
886293011027	PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate...; Region: PAF_acetylesterase_like; cd01820
886293011028	active site
886293011029	catalytic triad [active]
886293011030	oxyanion hole [active]
886293011031	specificity pocket; other site
886293011032	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
886293011033	dimer interface [polypeptide binding]; other site
886293011034	FMN binding site [chemical binding]; other site
886293011035	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293011036	amino acid transporter; Region: 2A0306; TIGR00909
886293011037	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
886293011038	Carbon starvation protein CstA; Region: CstA; pfam02554
886293011039	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
886293011040	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
886293011041	Carbon starvation protein CstA; Region: CstA; pfam02554
886293011042	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
886293011043	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
886293011044	putative rRNA binding site [nucleotide binding]; other site
886293011045	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293011046	OpgC protein; Region: OpgC_C; pfam10129
886293011047	Acyltransferase family; Region: Acyl_transf_3; pfam01757
886293011048	DDE superfamily endonuclease; Region: DDE_5; cl17874
886293011049	DDE superfamily endonuclease; Region: DDE_3; pfam13358
886293011050	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293011051	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293011052	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293011053	DNA binding residues [nucleotide binding]
886293011054	Bacterial Ig-like domain; Region: Big_5; pfam13205
886293011055	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
886293011056	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
886293011057	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
886293011058	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
886293011059	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
886293011060	Zn2+ binding site [ion binding]; other site
886293011061	Mg2+ binding site [ion binding]; other site
886293011062	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
886293011063	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
886293011064	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
886293011065	rRNA binding site [nucleotide binding]; other site
886293011066	predicted 30S ribosome binding site; other site
886293011067	sulfite reductase subunit beta; Provisional; Region: PRK13504
886293011068	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
886293011069	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
886293011070	DinB superfamily; Region: DinB_2; pfam12867
886293011071	metal-dependent hydrolase; Provisional; Region: PRK13291
886293011072	ECF sigma factor; Region: Sigma70_ECF; pfam07638
886293011073	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293011074	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293011075	active site
886293011076	ATP binding site [chemical binding]; other site
886293011077	substrate binding site [chemical binding]; other site
886293011078	activation loop (A-loop); other site
886293011079	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
886293011080	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
886293011081	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
886293011082	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
886293011083	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
886293011084	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
886293011085	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
886293011086	Cytochrome P450; Region: p450; pfam00067
886293011087	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
886293011088	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293011089	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
886293011090	putative active site [active]
886293011091	heme pocket [chemical binding]; other site
886293011092	PAS domain S-box; Region: sensory_box; TIGR00229
886293011093	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293011094	putative active site [active]
886293011095	heme pocket [chemical binding]; other site
886293011096	PAS domain S-box; Region: sensory_box; TIGR00229
886293011097	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
886293011098	Histidine kinase; Region: HisKA_3; pfam07730
886293011099	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293011100	ATP binding site [chemical binding]; other site
886293011101	Mg2+ binding site [ion binding]; other site
886293011102	G-X-G motif; other site
886293011103	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
886293011104	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
886293011105	PGAP1-like protein; Region: PGAP1; pfam07819
886293011106	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
886293011107	phosphopeptide binding site; other site
886293011108	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
886293011109	cyclase homology domain; Region: CHD; cd07302
886293011110	nucleotidyl binding site; other site
886293011111	metal binding site [ion binding]; metal-binding site
886293011112	dimer interface [polypeptide binding]; other site
886293011113	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293011114	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293011115	active site
886293011116	ATP binding site [chemical binding]; other site
886293011117	substrate binding site [chemical binding]; other site
886293011118	activation loop (A-loop); other site
886293011119	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
886293011120	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293011121	DevC protein; Region: devC; TIGR01185
886293011122	FtsX-like permease family; Region: FtsX; pfam02687
886293011123	DevC protein; Region: devC; TIGR01185
886293011124	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
886293011125	FtsX-like permease family; Region: FtsX; pfam02687
886293011126	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
886293011127	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
886293011128	Walker A/P-loop; other site
886293011129	ATP binding site [chemical binding]; other site
886293011130	Q-loop/lid; other site
886293011131	ABC transporter signature motif; other site
886293011132	Walker B; other site
886293011133	D-loop; other site
886293011134	H-loop/switch region; other site
886293011135	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
886293011136	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
886293011137	ligand binding site [chemical binding]; other site
886293011138	flexible hinge region; other site
886293011139	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
886293011140	classical (c) SDRs; Region: SDR_c; cd05233
886293011141	NAD(P) binding site [chemical binding]; other site
886293011142	active site
886293011143	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
886293011144	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
886293011145	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293011146	Walker A/P-loop; other site
886293011147	ATP binding site [chemical binding]; other site
886293011148	Q-loop/lid; other site
886293011149	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
886293011150	ABC transporter signature motif; other site
886293011151	Walker B; other site
886293011152	D-loop; other site
886293011153	ABC transporter; Region: ABC_tran_2; pfam12848
886293011154	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
886293011155	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293011156	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293011157	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
886293011158	NAD(P) binding site [chemical binding]; other site
886293011159	active site
886293011160	deoxyhypusine synthase-like protein; Provisional; Region: PRK02492
886293011161	deoxyhypusine synthase; Region: dhys; TIGR00321
886293011162	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
886293011163	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
886293011164	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293011165	Calx-beta domain; Region: Calx-beta; pfam03160
886293011166	Calx-beta domain; Region: Calx-beta; pfam03160
886293011167	Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237
886293011168	Right handed beta helix region; Region: Beta_helix; pfam13229
886293011169	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
886293011170	PEGA domain; Region: PEGA; pfam08308
886293011171	multifunctional aminopeptidase A; Provisional; Region: PRK00913
886293011172	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
886293011173	interface (dimer of trimers) [polypeptide binding]; other site
886293011174	Substrate-binding/catalytic site; other site
886293011175	Zn-binding sites [ion binding]; other site
886293011176	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
886293011177	protein binding site [polypeptide binding]; other site
886293011178	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
886293011179	Catalytic dyad [active]
886293011180	Family description; Region: VCBS; pfam13517
886293011181	Family description; Region: VCBS; pfam13517
886293011182	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
886293011183	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
886293011184	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293011185	TPR motif; other site
886293011186	binding surface
886293011187	Tetratricopeptide repeat; Region: TPR_16; pfam13432
886293011188	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293011189	TPR motif; other site
886293011190	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293011191	binding surface
886293011192	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
886293011193	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
886293011194	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
886293011195	Oligomerisation domain; Region: Oligomerisation; pfam02410
886293011196	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
886293011197	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
886293011198	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
886293011199	active site
886293011200	HIGH motif; other site
886293011201	KMSK motif region; other site
886293011202	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
886293011203	tRNA binding surface [nucleotide binding]; other site
886293011204	anticodon binding site; other site
886293011205	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
886293011206	Uncharacterized conserved protein [Function unknown]; Region: COG3391
886293011207	MoeA N-terminal region (domain I and II); Region: MoeA_N; pfam03453
886293011208	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
886293011209	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
886293011210	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
886293011211	ATP-grasp domain; Region: ATP-grasp_4; cl17255
886293011212	formaldehyde-activating enzyme; Region: one_C_fae; TIGR03126
886293011213	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
886293011214	NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078
886293011215	NADP binding site [chemical binding]; other site
886293011216	Protein of unknown function (DUF1464); Region: DUF1464; cl17839
886293011217	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
886293011218	aromatic arch; other site
886293011219	DCoH dimer interaction site [polypeptide binding]; other site
886293011220	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
886293011221	DCoH tetramer interaction site [polypeptide binding]; other site
886293011222	substrate binding site [chemical binding]; other site
886293011223	multidrug resistance protein MdtN; Provisional; Region: PRK10476
886293011224	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293011225	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
886293011226	Family description; Region: VCBS; pfam13517
886293011227	Family description; Region: VCBS; pfam13517
886293011228	Family description; Region: VCBS; pfam13517
886293011229	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
886293011230	amphipathic channel; other site
886293011231	Asn-Pro-Ala signature motifs; other site
886293011232	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
886293011233	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293011234	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
886293011235	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293011236	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293011237	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293011238	DNA binding residues [nucleotide binding]
886293011239	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293011240	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293011241	catalytic residues [active]
886293011242	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
886293011243	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
886293011244	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
886293011245	ligand binding site [chemical binding]; other site
886293011246	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
886293011247	ligand binding site [chemical binding]; other site
886293011248	flexible hinge region; other site
886293011249	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
886293011250	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
886293011251	4Fe-4S binding domain; Region: Fer4; pfam00037
886293011252	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
886293011253	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
886293011254	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
886293011255	cyclase homology domain; Region: CHD; cd07302
886293011256	nucleotidyl binding site; other site
886293011257	metal binding site [ion binding]; metal-binding site
886293011258	dimer interface [polypeptide binding]; other site
886293011259	Domain of unknown function (DUF1854); Region: DUF1854; pfam08909
886293011260	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
886293011261	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
886293011262	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
886293011263	Walker A/P-loop; other site
886293011264	ATP binding site [chemical binding]; other site
886293011265	Q-loop/lid; other site
886293011266	ABC transporter signature motif; other site
886293011267	Walker B; other site
886293011268	D-loop; other site
886293011269	H-loop/switch region; other site
886293011270	cyanophycin synthetase; Provisional; Region: PRK14016
886293011271	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
886293011272	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
886293011273	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
886293011274	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
886293011275	ketol-acid reductoisomerase; Provisional; Region: PRK05479
886293011276	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
886293011277	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
886293011278	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
886293011279	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
886293011280	putative valine binding site [chemical binding]; other site
886293011281	dimer interface [polypeptide binding]; other site
886293011282	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
886293011283	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
886293011284	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
886293011285	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
886293011286	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
886293011287	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
886293011288	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
886293011289	Walker A/P-loop; other site
886293011290	ATP binding site [chemical binding]; other site
886293011291	Q-loop/lid; other site
886293011292	ABC transporter signature motif; other site
886293011293	Walker B; other site
886293011294	D-loop; other site
886293011295	H-loop/switch region; other site
886293011296	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293011297	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293011298	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293011299	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
886293011300	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293011301	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293011302	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293011303	DNA binding residues [nucleotide binding]
886293011304	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
886293011305	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
886293011306	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293011307	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293011308	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293011309	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
886293011310	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
886293011311	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
886293011312	active site
886293011313	catalytic residues [active]
886293011314	metal binding site [ion binding]; metal-binding site
886293011315	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
886293011316	Protein of unknown function (DUF1569); Region: DUF1569; pfam07606
886293011317	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293011318	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293011319	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293011320	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
886293011321	transposase/IS protein; Provisional; Region: PRK09183
886293011322	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293011323	Walker A motif; other site
886293011324	ATP binding site [chemical binding]; other site
886293011325	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
886293011326	Integrase core domain; Region: rve; pfam00665
886293011327	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
886293011328	catalytic residues [active]
886293011329	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293011330	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293011331	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293011332	DNA binding residues [nucleotide binding]
886293011333	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293011334	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293011335	active site
886293011336	ATP binding site [chemical binding]; other site
886293011337	substrate binding site [chemical binding]; other site
886293011338	activation loop (A-loop); other site
886293011339	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293011340	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
886293011341	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
886293011342	glycyl-tRNA synthetase; Provisional; Region: PRK04173
886293011343	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
886293011344	motif 1; other site
886293011345	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
886293011346	active site
886293011347	motif 2; other site
886293011348	motif 3; other site
886293011349	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
886293011350	anticodon binding site; other site
886293011351	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293011352	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
886293011353	Metal-binding active site; metal-binding site
886293011354	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
886293011355	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293011356	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293011357	DNA binding residues [nucleotide binding]
886293011358	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
886293011359	dimer interface [polypeptide binding]; other site
886293011360	ADP-ribose binding site [chemical binding]; other site
886293011361	active site
886293011362	nudix motif; other site
886293011363	metal binding site [ion binding]; metal-binding site
886293011364	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
886293011365	Ligand Binding Site [chemical binding]; other site
886293011366	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
886293011367	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
886293011368	homodimer interface [polypeptide binding]; other site
886293011369	substrate-cofactor binding pocket; other site
886293011370	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293011371	catalytic residue [active]
886293011372	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
886293011373	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
886293011374	Walker A/P-loop; other site
886293011375	ATP binding site [chemical binding]; other site
886293011376	Q-loop/lid; other site
886293011377	ABC transporter signature motif; other site
886293011378	Walker B; other site
886293011379	D-loop; other site
886293011380	H-loop/switch region; other site
886293011381	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
886293011382	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
886293011383	FtsX-like permease family; Region: FtsX; pfam02687
886293011384	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
886293011385	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
886293011386	dimer interface [polypeptide binding]; other site
886293011387	putative anticodon binding site; other site
886293011388	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
886293011389	motif 1; other site
886293011390	active site
886293011391	motif 2; other site
886293011392	motif 3; other site
886293011393	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
886293011394	active site
886293011395	Transcriptional regulators [Transcription]; Region: PurR; COG1609
886293011396	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
886293011397	putative ligand binding site [chemical binding]; other site
886293011398	putative dimerization interface [polypeptide binding]; other site
886293011399	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
886293011400	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293011401	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293011402	prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294
886293011403	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293011404	HEAT repeats; Region: HEAT_2; pfam13646
886293011405	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293011406	Cytochrome c; Region: Cytochrom_C; pfam00034
886293011407	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
886293011408	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
886293011409	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293011410	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293011411	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293011412	catalytic residues [active]
886293011413	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
886293011414	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
886293011415	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293011416	Coenzyme A binding pocket [chemical binding]; other site
886293011417	Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162
886293011418	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
886293011419	Protein of unknown function DUF104; Region: DUF104; pfam01954
886293011420	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778
886293011421	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
886293011422	TPP-binding site [chemical binding]; other site
886293011423	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
886293011424	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
886293011425	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
886293011426	dimer interface [polypeptide binding]; other site
886293011427	PYR/PP interface [polypeptide binding]; other site
886293011428	TPP binding site [chemical binding]; other site
886293011429	substrate binding site [chemical binding]; other site
886293011430	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
886293011431	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
886293011432	Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504
886293011433	Domain of unknown function DUF11; Region: DUF11; pfam01345
886293011434	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
886293011435	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
886293011436	catalytic residues [active]
886293011437	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
886293011438	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
886293011439	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
886293011440	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293011441	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
886293011442	Transcription antiterminator [Transcription]; Region: NusG; COG0250
886293011443	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
886293011444	heterodimer interface [polypeptide binding]; other site
886293011445	homodimer interface [polypeptide binding]; other site
886293011446	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
886293011447	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
886293011448	RNA binding site [nucleotide binding]; other site
886293011449	active site
886293011450	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
886293011451	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
886293011452	HflX GTPase family; Region: HflX; cd01878
886293011453	G1 box; other site
886293011454	GTP/Mg2+ binding site [chemical binding]; other site
886293011455	Switch I region; other site
886293011456	G2 box; other site
886293011457	G3 box; other site
886293011458	Switch II region; other site
886293011459	G4 box; other site
886293011460	G5 box; other site
886293011461	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
886293011462	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
886293011463	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
886293011464	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
886293011465	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156
886293011466	putative active site [active]
886293011467	catalytic site [active]
886293011468	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162
886293011469	putative active site [active]
886293011470	catalytic site [active]
886293011471	Uncharacterized conserved protein [Function unknown]; Region: COG1262
886293011472	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
886293011473	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
886293011474	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
886293011475	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
886293011476	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
886293011477	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
886293011478	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
886293011479	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293011480	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293011481	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293011482	DNA binding residues [nucleotide binding]
886293011483	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293011484	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293011485	Catalytic domain of vertebrate phospholipase D6 and similar proteins; Region: PLDc_vPLD6_like; cd09171
886293011486	PLD-like domain; Region: PLDc_2; pfam13091
886293011487	putative active site [active]
886293011488	catalytic site [active]
886293011489	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293011490	PemK-like protein; Region: PemK; pfam02452
886293011491	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
886293011492	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
886293011493	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
886293011494	hexamer (dimer of trimers) interface [polypeptide binding]; other site
886293011495	substrate binding site [chemical binding]; other site
886293011496	trimer interface [polypeptide binding]; other site
886293011497	Mn binding site [ion binding]; other site
886293011498	mercuric reductase; Validated; Region: PRK06370
886293011499	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
886293011500	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
886293011501	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
886293011502	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
886293011503	PHB binding site; other site
886293011504	CoenzymeA binding site [chemical binding]; other site
886293011505	subunit interaction site [polypeptide binding]; other site
886293011506	4Fe-4S binding domain; Region: Fer4; pfam00037
886293011507	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
886293011508	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
886293011509	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650
886293011510	Region in Clathrin and VPS; Region: Clathrin; pfam00637
886293011511	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
886293011512	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
886293011513	Ligand binding site; other site
886293011514	Putative Catalytic site; other site
886293011515	DXD motif; other site
886293011516	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293011517	Coenzyme A binding pocket [chemical binding]; other site
886293011518	Sterol carrier protein domain; Region: SCP2_2; pfam13530
886293011519	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
886293011520	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
886293011521	putative hydrophobic ligand binding site [chemical binding]; other site
886293011522	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293011523	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293011524	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
886293011525	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
886293011526	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
886293011527	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
886293011528	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293011529	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293011530	protein binding site [polypeptide binding]; other site
886293011531	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293011532	protein binding site [polypeptide binding]; other site
886293011533	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
886293011534	TPR repeat; Region: TPR_11; pfam13414
886293011535	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293011536	TPR motif; other site
886293011537	binding surface
886293011538	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
886293011539	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
886293011540	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
886293011541	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
886293011542	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293011543	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293011544	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293011545	CTP synthetase; Validated; Region: pyrG; PRK05380
886293011546	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
886293011547	Catalytic site [active]
886293011548	active site
886293011549	UTP binding site [chemical binding]; other site
886293011550	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
886293011551	active site
886293011552	putative oxyanion hole; other site
886293011553	catalytic triad [active]
886293011554	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293011555	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
886293011556	active site
886293011557	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
886293011558	Coenzyme A binding pocket [chemical binding]; other site
886293011559	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
886293011560	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
886293011561	anti sigma factor interaction site; other site
886293011562	regulatory phosphorylation site [posttranslational modification]; other site
886293011563	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
886293011564	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
886293011565	inhibitor site; inhibition site
886293011566	active site
886293011567	dimer interface [polypeptide binding]; other site
886293011568	catalytic residue [active]
886293011569	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
886293011570	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
886293011571	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
886293011572	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
886293011573	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
886293011574	catalytic residue [active]
886293011575	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
886293011576	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293011577	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293011578	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293011579	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293011580	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
886293011581	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
886293011582	hexamer interface [polypeptide binding]; other site
886293011583	ligand binding site [chemical binding]; other site
886293011584	putative active site [active]
886293011585	NAD(P) binding site [chemical binding]; other site
886293011586	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
886293011587	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
886293011588	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
886293011589	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537
886293011590	ATP-sulfurylase; Region: ATPS; cd00517
886293011591	active site
886293011592	HXXH motif; other site
886293011593	flexible loop; other site
886293011594	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
886293011595	ligand-binding site [chemical binding]; other site
886293011596	Predicted transcriptional regulator [Transcription]; Region: COG1959
886293011597	Transcriptional regulator; Region: Rrf2; pfam02082
886293011598	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
886293011599	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
886293011600	Active Sites [active]
886293011601	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
886293011602	type IV pilus assembly protein PilM; Region: pilM; TIGR01175
886293011603	Cell division protein FtsA; Region: FtsA; pfam14450
886293011604	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
886293011605	Peptidase family M28; Region: Peptidase_M28; pfam04389
886293011606	metal binding site [ion binding]; metal-binding site
886293011607	Maf-like protein; Region: Maf; pfam02545
886293011608	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
886293011609	active site
886293011610	dimer interface [polypeptide binding]; other site
886293011611	Family description; Region: VCBS; pfam13517
886293011612	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293011613	HEAT repeats; Region: HEAT_2; pfam13646
886293011614	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293011615	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
886293011616	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
886293011617	putative metal binding site [ion binding]; other site
886293011618	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
886293011619	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
886293011620	metal binding site [ion binding]; metal-binding site
886293011621	Enolase C-terminal domain-like; Region: MR_MLE_C; pfam13378
886293011622	substrate binding pocket [chemical binding]; other site
886293011623	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293011624	Major Facilitator Superfamily; Region: MFS_1; pfam07690
886293011625	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293011626	EVE domain; Region: EVE; cl00728
886293011627	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
886293011628	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
886293011629	active site
886293011630	metal binding site [ion binding]; metal-binding site
886293011631	DEAD-like helicases superfamily; Region: DEXDc; smart00487
886293011632	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
886293011633	ATP binding site [chemical binding]; other site
886293011634	putative Mg++ binding site [ion binding]; other site
886293011635	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293011636	nucleotide binding region [chemical binding]; other site
886293011637	ATP-binding site [chemical binding]; other site
886293011638	RQC domain; Region: RQC; pfam09382
886293011639	HRDC domain; Region: HRDC; pfam00570
886293011640	Methyltransferase domain; Region: Methyltransf_23; pfam13489
886293011641	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293011642	S-adenosylmethionine binding site [chemical binding]; other site
886293011643	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
886293011644	hypothetical protein; Reviewed; Region: PRK09588
886293011645	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
886293011646	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293011647	Walker A/P-loop; other site
886293011648	ATP binding site [chemical binding]; other site
886293011649	Q-loop/lid; other site
886293011650	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
886293011651	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
886293011652	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
886293011653	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
886293011654	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
886293011655	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
886293011656	TM-ABC transporter signature motif; other site
886293011657	Ion channel; Region: Ion_trans_2; pfam07885
886293011658	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
886293011659	TrkA-N domain; Region: TrkA_N; pfam02254
886293011660	TrkA-C domain; Region: TrkA_C; pfam02080
886293011661	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
886293011662	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
886293011663	23S rRNA interface [nucleotide binding]; other site
886293011664	L3 interface [polypeptide binding]; other site
886293011665	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293011666	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293011667	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293011668	DNA binding residues [nucleotide binding]
886293011669	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
886293011670	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
886293011671	motif 1; other site
886293011672	active site
886293011673	motif 2; other site
886293011674	motif 3; other site
886293011675	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
886293011676	DHHA1 domain; Region: DHHA1; pfam02272
886293011677	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293011678	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293011679	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293011680	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
886293011681	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
886293011682	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
886293011683	Methyltransferase domain; Region: Methyltransf_31; pfam13847
886293011684	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293011685	S-adenosylmethionine binding site [chemical binding]; other site
886293011686	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293011687	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
886293011688	metal binding site [ion binding]; metal-binding site
886293011689	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
886293011690	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
886293011691	Ligand Binding Site [chemical binding]; other site
886293011692	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
886293011693	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293011694	Predicted membrane protein [Function unknown]; Region: COG2246
886293011695	GtrA-like protein; Region: GtrA; pfam04138
886293011696	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
886293011697	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
886293011698	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
886293011699	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
886293011700	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293011701	extended (e) SDRs; Region: SDR_e; cd08946
886293011702	NAD(P) binding site [chemical binding]; other site
886293011703	active site
886293011704	substrate binding site [chemical binding]; other site
886293011705	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
886293011706	camphor resistance protein CrcB; Provisional; Region: PRK14195
886293011707	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
886293011708	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
886293011709	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
886293011710	FeoA domain; Region: FeoA; pfam04023
886293011711	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
886293011712	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
886293011713	putative RNA binding site [nucleotide binding]; other site
886293011714	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293011715	S-adenosylmethionine binding site [chemical binding]; other site
886293011716	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617
886293011717	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
886293011718	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
886293011719	putative NAD(P) binding site [chemical binding]; other site
886293011720	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
886293011721	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
886293011722	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
886293011723	Substrate binding site; other site
886293011724	Cupin domain; Region: Cupin_2; cl17218
886293011725	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293011726	active site
886293011727	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
886293011728	putative hydrolase; Provisional; Region: PRK02113
886293011729	preprotein translocase, SecA subunit; Region: secA; TIGR00963
886293011730	DEAD/DEAH box helicase; Region: DEAD; pfam00270
886293011731	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
886293011732	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293011733	nucleotide binding region [chemical binding]; other site
886293011734	SEC-C motif; Region: SEC-C; pfam02810
886293011735	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
886293011736	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
886293011737	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
886293011738	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
886293011739	Domain of unknown function (DUF309); Region: DUF309; pfam03745
886293011740	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
886293011741	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
886293011742	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
886293011743	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
886293011744	active site
886293011745	dimer interface [polypeptide binding]; other site
886293011746	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
886293011747	Ligand Binding Site [chemical binding]; other site
886293011748	Molecular Tunnel; other site
886293011749	Predicted amidohydrolase [General function prediction only]; Region: COG0388
886293011750	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
886293011751	active site
886293011752	catalytic triad [active]
886293011753	dimer interface [polypeptide binding]; other site
886293011754	Predicted transcriptional regulators [Transcription]; Region: COG1510
886293011755	MarR family; Region: MarR_2; pfam12802
886293011756	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293011757	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293011758	catalytic residues [active]
886293011759	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293011760	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293011761	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
886293011762	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
886293011763	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293011764	phosphopeptide binding site; other site
886293011765	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
886293011766	active site
886293011767	PQQ-like domain; Region: PQQ_2; pfam13360
886293011768	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
886293011769	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
886293011770	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293011771	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
886293011772	hydroxyglutarate oxidase; Provisional; Region: PRK11728
886293011773	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
886293011774	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
886293011775	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
886293011776	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293011777	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
886293011778	active site
886293011779	motif I; other site
886293011780	motif II; other site
886293011781	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
886293011782	Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762
886293011783	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
886293011784	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
886293011785	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
886293011786	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
886293011787	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293011788	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
886293011789	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293011790	RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984
886293011791	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293011792	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293011793	active site
886293011794	ATP binding site [chemical binding]; other site
886293011795	substrate binding site [chemical binding]; other site
886293011796	activation loop (A-loop); other site
886293011797	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293011798	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293011799	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
886293011800	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
886293011801	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
886293011802	Protein of unknown function (DUF3754); Region: DUF3754; pfam12576
886293011803	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293011804	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
886293011805	active site lid residues [active]
886293011806	substrate binding pocket [chemical binding]; other site
886293011807	catalytic residues [active]
886293011808	substrate-Mg2+ binding site; other site
886293011809	aspartate-rich region 1; other site
886293011810	aspartate-rich region 2; other site
886293011811	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
886293011812	active site lid residues [active]
886293011813	substrate binding pocket [chemical binding]; other site
886293011814	catalytic residues [active]
886293011815	substrate-Mg2+ binding site; other site
886293011816	aspartate-rich region 1; other site
886293011817	aspartate-rich region 2; other site
886293011818	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
886293011819	Response regulator receiver domain; Region: Response_reg; pfam00072
886293011820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293011821	active site
886293011822	phosphorylation site [posttranslational modification]
886293011823	intermolecular recognition site; other site
886293011824	dimerization interface [polypeptide binding]; other site
886293011825	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
886293011826	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
886293011827	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
886293011828	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
886293011829	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
886293011830	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
886293011831	DoxX-like family; Region: DoxX_2; pfam13564
886293011832	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
886293011833	Protein of unknown function (DUF1579); Region: DUF1579; pfam07617
886293011834	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
886293011835	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
886293011836	DNA binding residues [nucleotide binding]
886293011837	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
886293011838	Fatty acid desaturase; Region: FA_desaturase; pfam00487
886293011839	putative di-iron ligands [ion binding]; other site
886293011840	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
886293011841	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
886293011842	Walker A/P-loop; other site
886293011843	ATP binding site [chemical binding]; other site
886293011844	Q-loop/lid; other site
886293011845	ABC transporter signature motif; other site
886293011846	Walker B; other site
886293011847	D-loop; other site
886293011848	H-loop/switch region; other site
886293011849	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
886293011850	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
886293011851	substrate binding pocket [chemical binding]; other site
886293011852	membrane-bound complex binding site; other site
886293011853	hinge residues; other site
886293011854	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
886293011855	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
886293011856	dimer interface [polypeptide binding]; other site
886293011857	conserved gate region; other site
886293011858	putative PBP binding loops; other site
886293011859	ABC-ATPase subunit interface; other site
886293011860	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
886293011861	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
886293011862	ligand binding site; other site
886293011863	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
886293011864	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293011865	S-adenosylmethionine binding site [chemical binding]; other site
886293011866	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
886293011867	putative active site [active]
886293011868	putative metal binding residues [ion binding]; other site
886293011869	signature motif; other site
886293011870	putative triphosphate binding site [ion binding]; other site
886293011871	dimer interface [polypeptide binding]; other site
886293011872	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
886293011873	PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750
886293011874	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
886293011875	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
886293011876	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
886293011877	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
886293011878	homodimer interface [polypeptide binding]; other site
886293011879	substrate-cofactor binding pocket; other site
886293011880	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293011881	catalytic residue [active]
886293011882	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
886293011883	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
886293011884	Type II/IV secretion system protein; Region: T2SE; pfam00437
886293011885	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
886293011886	Walker A motif; other site
886293011887	ATP binding site [chemical binding]; other site
886293011888	Walker B motif; other site
886293011889	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
886293011890	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
886293011891	Walker A motif; other site
886293011892	ATP binding site [chemical binding]; other site
886293011893	Walker B motif; other site
886293011894	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
886293011895	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
886293011896	substrate binding site [chemical binding]; other site
886293011897	glutamase interaction surface [polypeptide binding]; other site
886293011898	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
886293011899	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
886293011900	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
886293011901	bifunctional sulfur carrier protein/thiazole synthase protein; Provisional; Region: PRK11840
886293011902	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
886293011903	thiS-thiF/thiG interaction site; other site
886293011904	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
886293011905	ThiS interaction site; other site
886293011906	putative active site [active]
886293011907	tetramer interface [polypeptide binding]; other site
886293011908	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
886293011909	active site
886293011910	putative DNA-binding cleft [nucleotide binding]; other site
886293011911	dimer interface [polypeptide binding]; other site
886293011912	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
886293011913	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
886293011914	active site
886293011915	HIGH motif; other site
886293011916	nucleotide binding site [chemical binding]; other site
886293011917	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
886293011918	KMSKS motif; other site
886293011919	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
886293011920	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
886293011921	homotrimer interaction site [polypeptide binding]; other site
886293011922	zinc binding site [ion binding]; other site
886293011923	CDP-binding sites; other site
886293011924	Global regulator protein family; Region: CsrA; pfam02599
886293011925	Global regulator protein family; Region: CsrA; pfam02599
886293011926	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
886293011927	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
886293011928	active site
886293011929	catalytic tetrad [active]
886293011930	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
886293011931	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
886293011932	Ribosomal protein S21; Region: Ribosomal_S21; pfam01165
886293011933	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
886293011934	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
886293011935	tetramer interface [polypeptide binding]; other site
886293011936	active site
886293011937	glutamate dehydrogenase; Region: PLN02477
886293011938	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
886293011939	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
886293011940	NAD(P) binding site [chemical binding]; other site
886293011941	Creatinine amidohydrolase; Region: Creatininase; pfam02633
886293011942	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
886293011943	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
886293011944	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
886293011945	Cu(I) binding site [ion binding]; other site
886293011946	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293011947	dimerization interface [polypeptide binding]; other site
886293011948	putative DNA binding site [nucleotide binding]; other site
886293011949	putative Zn2+ binding site [ion binding]; other site
886293011950	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
886293011951	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293011952	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293011953	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293011954	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293011955	structural tetrad; other site
886293011956	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
886293011957	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
886293011958	putative [4Fe-4S] binding site [ion binding]; other site
886293011959	putative molybdopterin cofactor binding site [chemical binding]; other site
886293011960	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
886293011961	putative molybdopterin cofactor binding site; other site
886293011962	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
886293011963	Beta-lactamase; Region: Beta-lactamase; pfam00144
886293011964	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
886293011965	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
886293011966	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293011967	dimerization interface [polypeptide binding]; other site
886293011968	putative DNA binding site [nucleotide binding]; other site
886293011969	putative Zn2+ binding site [ion binding]; other site
886293011970	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
886293011971	CHASE3 domain; Region: CHASE3; pfam05227
886293011972	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293011973	dimer interface [polypeptide binding]; other site
886293011974	phosphorylation site [posttranslational modification]
886293011975	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293011976	ATP binding site [chemical binding]; other site
886293011977	Mg2+ binding site [ion binding]; other site
886293011978	G-X-G motif; other site
886293011979	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293011980	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293011981	active site
886293011982	phosphorylation site [posttranslational modification]
886293011983	intermolecular recognition site; other site
886293011984	dimerization interface [polypeptide binding]; other site
886293011985	Response regulator receiver domain; Region: Response_reg; pfam00072
886293011986	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293011987	active site
886293011988	phosphorylation site [posttranslational modification]
886293011989	intermolecular recognition site; other site
886293011990	dimerization interface [polypeptide binding]; other site
886293011991	Hpt domain; Region: Hpt; pfam01627
886293011992	Response regulator receiver domain; Region: Response_reg; pfam00072
886293011993	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293011994	active site
886293011995	phosphorylation site [posttranslational modification]
886293011996	intermolecular recognition site; other site
886293011997	dimerization interface [polypeptide binding]; other site
886293011998	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
886293011999	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
886293012000	metal binding site [ion binding]; metal-binding site
886293012001	active site
886293012002	I-site; other site
886293012003	MarR family; Region: MarR_2; cl17246
886293012004	Predicted transcriptional regulator [Transcription]; Region: COG2345
886293012005	FeS assembly ATPase SufC; Region: sufC; TIGR01978
886293012006	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
886293012007	Walker A/P-loop; other site
886293012008	ATP binding site [chemical binding]; other site
886293012009	Q-loop/lid; other site
886293012010	ABC transporter signature motif; other site
886293012011	Walker B; other site
886293012012	D-loop; other site
886293012013	H-loop/switch region; other site
886293012014	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
886293012015	FeS assembly protein SufB; Region: sufB; TIGR01980
886293012016	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
886293012017	FeS assembly protein SufD; Region: sufD; TIGR01981
886293012018	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
886293012019	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
886293012020	active site residue [active]
886293012021	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
886293012022	active site residue [active]
886293012023	Fe-S metabolism associated domain; Region: SufE; cl00951
886293012024	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
886293012025	[2Fe-2S] cluster binding site [ion binding]; other site
886293012026	Domain of unknown function DUF59; Region: DUF59; cl00941
886293012027	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293012028	non-specific DNA binding site [nucleotide binding]; other site
886293012029	salt bridge; other site
886293012030	sequence-specific DNA binding site [nucleotide binding]; other site
886293012031	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
886293012032	Catalytic site [active]
886293012033	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
886293012034	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
886293012035	PAS domain; Region: PAS_9; pfam13426
886293012036	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
886293012037	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293012038	Walker A motif; other site
886293012039	ATP binding site [chemical binding]; other site
886293012040	Walker B motif; other site
886293012041	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
886293012042	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
886293012043	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
886293012044	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
886293012045	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
886293012046	catalytic residues [active]
886293012047	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
886293012048	C-terminal peptidase (prc); Region: prc; TIGR00225
886293012049	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
886293012050	protein binding site [polypeptide binding]; other site
886293012051	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
886293012052	Catalytic dyad [active]
886293012053	UGMP family protein; Validated; Region: PRK09604
886293012054	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
886293012055	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
886293012056	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
886293012057	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293012058	motif II; other site
886293012059	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
886293012060	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
886293012061	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
886293012062	trimer interface [polypeptide binding]; other site
886293012063	active site
886293012064	UDP-GlcNAc binding site [chemical binding]; other site
886293012065	lipid binding site [chemical binding]; lipid-binding site
886293012066	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
886293012067	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
886293012068	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
886293012069	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
886293012070	active site
886293012071	trimer interface [polypeptide binding]; other site
886293012072	allosteric site; other site
886293012073	active site lid [active]
886293012074	hexamer (dimer of trimers) interface [polypeptide binding]; other site
886293012075	benzoate transport; Region: 2A0115; TIGR00895
886293012076	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293012077	putative substrate translocation pore; other site
886293012078	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
886293012079	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293012080	Response regulator receiver domain; Region: Response_reg; pfam00072
886293012081	active site
886293012082	phosphorylation site [posttranslational modification]
886293012083	intermolecular recognition site; other site
886293012084	dimerization interface [polypeptide binding]; other site
886293012085	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293012086	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293012087	active site
886293012088	phosphorylation site [posttranslational modification]
886293012089	intermolecular recognition site; other site
886293012090	dimerization interface [polypeptide binding]; other site
886293012091	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293012092	dimer interface [polypeptide binding]; other site
886293012093	phosphorylation site [posttranslational modification]
886293012094	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293012095	ATP binding site [chemical binding]; other site
886293012096	Mg2+ binding site [ion binding]; other site
886293012097	G-X-G motif; other site
886293012098	Response regulator receiver domain; Region: Response_reg; pfam00072
886293012099	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293012100	active site
886293012101	phosphorylation site [posttranslational modification]
886293012102	intermolecular recognition site; other site
886293012103	dimerization interface [polypeptide binding]; other site
886293012104	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293012105	PAS domain; Region: PAS_9; pfam13426
886293012106	putative active site [active]
886293012107	heme pocket [chemical binding]; other site
886293012108	PAS domain S-box; Region: sensory_box; TIGR00229
886293012109	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293012110	putative active site [active]
886293012111	heme pocket [chemical binding]; other site
886293012112	PAS domain S-box; Region: sensory_box; TIGR00229
886293012113	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293012114	putative active site [active]
886293012115	heme pocket [chemical binding]; other site
886293012116	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
886293012117	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293012118	putative active site [active]
886293012119	heme pocket [chemical binding]; other site
886293012120	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293012121	ATP binding site [chemical binding]; other site
886293012122	Mg2+ binding site [ion binding]; other site
886293012123	G-X-G motif; other site
886293012124	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
886293012125	dimer interface [polypeptide binding]; other site
886293012126	[2Fe-2S] cluster binding site [ion binding]; other site
886293012127	Pantoate-beta-alanine ligase; Region: PanC; cd00560
886293012128	pantoate--beta-alanine ligase; Region: panC; TIGR00018
886293012129	active site
886293012130	ATP-binding site [chemical binding]; other site
886293012131	pantoate-binding site; other site
886293012132	HXXH motif; other site
886293012133	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
886293012134	tetramerization interface [polypeptide binding]; other site
886293012135	active site
886293012136	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
886293012137	MoxR-like ATPases [General function prediction only]; Region: COG0714
886293012138	ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726
886293012139	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293012140	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
886293012141	phosphopeptide binding site; other site
886293012142	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
886293012143	glycine dehydrogenase subunit 2; Validated; Region: PRK04366
886293012144	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
886293012145	catalytic residue [active]
886293012146	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
886293012147	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
886293012148	tetramer interface [polypeptide binding]; other site
886293012149	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293012150	catalytic residue [active]
886293012151	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
886293012152	lipoyl attachment site [posttranslational modification]; other site
886293012153	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
886293012154	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
886293012155	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293012156	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
886293012157	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293012158	Bacterial sugar transferase; Region: Bac_transf; pfam02397
886293012159	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
886293012160	Predicted peptidase [General function prediction only]; Region: COG4099
886293012161	VanZ like family; Region: VanZ; pfam04892
886293012162	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
886293012163	putative ADP-binding pocket [chemical binding]; other site
886293012164	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293012165	Walker A/P-loop; other site
886293012166	ATP binding site [chemical binding]; other site
886293012167	Q-loop/lid; other site
886293012168	ABC transporter signature motif; other site
886293012169	Walker B; other site
886293012170	D-loop; other site
886293012171	H-loop/switch region; other site
886293012172	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293012173	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
886293012174	endonuclease IV; Provisional; Region: PRK01060
886293012175	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
886293012176	AP (apurinic/apyrimidinic) site pocket; other site
886293012177	DNA interaction; other site
886293012178	Metal-binding active site; metal-binding site
886293012179	polyphosphate kinase; Provisional; Region: PRK05443
886293012180	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
886293012181	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
886293012182	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
886293012183	putative domain interface [polypeptide binding]; other site
886293012184	putative active site [active]
886293012185	catalytic site [active]
886293012186	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
886293012187	putative domain interface [polypeptide binding]; other site
886293012188	putative active site [active]
886293012189	catalytic site [active]
886293012190	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
886293012191	catalytic core [active]
886293012192	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
886293012193	Amidinotransferase; Region: Amidinotransf; pfam02274
886293012194	Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144
886293012195	Uncharacterized conserved protein [Function unknown]; Region: COG1915
886293012196	homodimer interface [polypeptide binding]; other site
886293012197	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
886293012198	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
886293012199	active site
886293012200	HslU subunit interaction site [polypeptide binding]; other site
886293012201	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
886293012202	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293012203	Walker A motif; other site
886293012204	ATP binding site [chemical binding]; other site
886293012205	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
886293012206	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
886293012207	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
886293012208	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293012209	active site
886293012210	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293012211	flavoprotein, HI0933 family; Region: TIGR00275
886293012212	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
886293012213	Low affinity iron permease; Region: Iron_permease; pfam04120
886293012214	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
886293012215	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
886293012216	thiamine monophosphate kinase; Provisional; Region: PRK05731
886293012217	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
886293012218	ATP binding site [chemical binding]; other site
886293012219	dimerization interface [polypeptide binding]; other site
886293012220	glycerate kinase; Region: TIGR00045
886293012221	Global regulator protein family; Region: CsrA; pfam02599
886293012222	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
886293012223	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
886293012224	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
886293012225	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
886293012226	active site
886293012227	Zn binding site [ion binding]; other site
886293012228	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
886293012229	RNA binding site [nucleotide binding]; other site
886293012230	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
886293012231	RNA binding site [nucleotide binding]; other site
886293012232	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
886293012233	RNA binding site [nucleotide binding]; other site
886293012234	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
886293012235	RNA binding site [nucleotide binding]; other site
886293012236	Domon-like ligand-binding domains; Region: DOMON_like; cd00241
886293012237	putative ligand binding site [chemical binding]; other site
886293012238	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
886293012239	homopentamer interface [polypeptide binding]; other site
886293012240	active site
886293012241	transcription termination factor Rho; Provisional; Region: rho; PRK09376
886293012242	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
886293012243	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
886293012244	RNA binding site [nucleotide binding]; other site
886293012245	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
886293012246	multimer interface [polypeptide binding]; other site
886293012247	Walker A motif; other site
886293012248	ATP binding site [chemical binding]; other site
886293012249	Walker B motif; other site
886293012250	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
886293012251	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
886293012252	CoA-binding site [chemical binding]; other site
886293012253	ATP-binding [chemical binding]; other site
886293012254	DNA polymerase I; Provisional; Region: PRK05755
886293012255	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
886293012256	active site
886293012257	metal binding site 1 [ion binding]; metal-binding site
886293012258	putative 5' ssDNA interaction site; other site
886293012259	metal binding site 3; metal-binding site
886293012260	metal binding site 2 [ion binding]; metal-binding site
886293012261	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
886293012262	putative DNA binding site [nucleotide binding]; other site
886293012263	putative metal binding site [ion binding]; other site
886293012264	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
886293012265	active site
886293012266	catalytic site [active]
886293012267	substrate binding site [chemical binding]; other site
886293012268	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
886293012269	active site
886293012270	DNA binding site [nucleotide binding]
886293012271	catalytic site [active]
886293012272	Protein of unknown function (DUF812); Region: DUF812; pfam05667
886293012273	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
886293012274	Citrate synthase; Region: Citrate_synt; pfam00285
886293012275	oxalacetate binding site [chemical binding]; other site
886293012276	citrylCoA binding site [chemical binding]; other site
886293012277	coenzyme A binding site [chemical binding]; other site
886293012278	catalytic triad [active]
886293012279	Predicted transcriptional regulators [Transcription]; Region: COG1510
886293012280	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293012281	putative DNA binding site [nucleotide binding]; other site
886293012282	putative Zn2+ binding site [ion binding]; other site
886293012283	HicB family; Region: HicB; pfam05534
886293012284	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293012285	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
886293012286	nucleoside/Zn binding site; other site
886293012287	dimer interface [polypeptide binding]; other site
886293012288	catalytic motif [active]
886293012289	BON domain; Region: BON; pfam04972
886293012290	BON domain; Region: BON; pfam04972
886293012291	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
886293012292	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
886293012293	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
886293012294	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
886293012295	putative active site [active]
886293012296	catalytic site [active]
886293012297	putative metal binding site [ion binding]; other site
886293012298	Bacterial Ig-like domain; Region: Big_5; pfam13205
886293012299	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293012300	active site
886293012301	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
886293012302	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
886293012303	dimer interface [polypeptide binding]; other site
886293012304	putative functional site; other site
886293012305	putative MPT binding site; other site
886293012306	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293012307	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293012308	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293012309	DNA binding residues [nucleotide binding]
886293012310	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293012311	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293012312	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293012313	structural tetrad; other site
886293012314	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
886293012315	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293012316	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293012317	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293012318	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293012319	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
886293012320	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
886293012321	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
886293012322	Probable Catalytic site; other site
886293012323	metal-binding site
886293012324	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
886293012325	Bacterial sugar transferase; Region: Bac_transf; pfam02397
886293012326	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
886293012327	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
886293012328	Probable Catalytic site; other site
886293012329	metal-binding site
886293012330	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
886293012331	Cytochrome P450; Region: p450; pfam00067
886293012332	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
886293012333	HEAT repeats; Region: HEAT_2; pfam13646
886293012334	protein binding surface [polypeptide binding]; other site
886293012335	HEAT repeats; Region: HEAT_2; pfam13646
886293012336	HEAT repeats; Region: HEAT_2; pfam13646
886293012337	HEAT repeats; Region: HEAT_2; pfam13646
886293012338	HEAT repeats; Region: HEAT_2; pfam13646
886293012339	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
886293012340	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
886293012341	active site
886293012342	substrate binding site [chemical binding]; other site
886293012343	metal binding site [ion binding]; metal-binding site
886293012344	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
886293012345	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
886293012346	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293012347	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
886293012348	DNA binding residues [nucleotide binding]
886293012349	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
886293012350	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
886293012351	catalytic triad [active]
886293012352	Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951
886293012353	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
886293012354	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
886293012355	substrate binding site [chemical binding]; other site
886293012356	ATP binding site [chemical binding]; other site
886293012357	FtsH Extracellular; Region: FtsH_ext; pfam06480
886293012358	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
886293012359	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293012360	Walker A motif; other site
886293012361	ATP binding site [chemical binding]; other site
886293012362	Walker B motif; other site
886293012363	arginine finger; other site
886293012364	Peptidase family M41; Region: Peptidase_M41; pfam01434
886293012365	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
886293012366	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
886293012367	Global regulator protein family; Region: CsrA; pfam02599
886293012368	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
886293012369	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293012370	active site
886293012371	phosphorylation site [posttranslational modification]
886293012372	intermolecular recognition site; other site
886293012373	dimerization interface [polypeptide binding]; other site
886293012374	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
886293012375	DNA binding site [nucleotide binding]
886293012376	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
886293012377	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
886293012378	Walker A/P-loop; other site
886293012379	ATP binding site [chemical binding]; other site
886293012380	Q-loop/lid; other site
886293012381	ABC transporter signature motif; other site
886293012382	Walker B; other site
886293012383	D-loop; other site
886293012384	H-loop/switch region; other site
886293012385	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
886293012386	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
886293012387	dimer interface [polypeptide binding]; other site
886293012388	conserved gate region; other site
886293012389	putative PBP binding loops; other site
886293012390	ABC-ATPase subunit interface; other site
886293012391	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
886293012392	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
886293012393	dimer interface [polypeptide binding]; other site
886293012394	conserved gate region; other site
886293012395	putative PBP binding loops; other site
886293012396	ABC-ATPase subunit interface; other site
886293012397	PBP superfamily domain; Region: PBP_like_2; cl17296
886293012398	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
886293012399	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293012400	putative active site [active]
886293012401	heme pocket [chemical binding]; other site
886293012402	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293012403	dimer interface [polypeptide binding]; other site
886293012404	phosphorylation site [posttranslational modification]
886293012405	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293012406	ATP binding site [chemical binding]; other site
886293012407	Mg2+ binding site [ion binding]; other site
886293012408	G-X-G motif; other site
886293012409	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
886293012410	Peptidase of plants and bacteria; Region: BSP; pfam04450
886293012411	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293012412	Sulfatase; Region: Sulfatase; pfam00884
886293012413	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293012414	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
886293012415	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
886293012416	active site
886293012417	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
886293012418	TPR repeat; Region: TPR_11; pfam13414
886293012419	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
886293012420	SpoVG; Region: SpoVG; pfam04026
886293012421	Double zinc ribbon; Region: DZR; pfam12773
886293012422	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
886293012423	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293012424	CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507
886293012425	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
886293012426	putative active site [active]
886293012427	catalytic triad [active]
886293012428	LabA_like proteins; Region: LabA_like; cd06167
886293012429	Uncharacterized conserved protein [Function unknown]; Region: COG1432
886293012430	putative metal binding site [ion binding]; other site
886293012431	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
886293012432	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046
886293012433	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
886293012434	dimerization interface [polypeptide binding]; other site
886293012435	ATP binding site [chemical binding]; other site
886293012436	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
886293012437	dimerization interface [polypeptide binding]; other site
886293012438	ATP binding site [chemical binding]; other site
886293012439	Prephenate dehydrogenase; Region: PDH; pfam02153
886293012440	prephenate dehydrogenase; Validated; Region: PRK08507
886293012441	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293012442	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
886293012443	phosphopeptide binding site; other site
886293012444	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293012445	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293012446	active site
886293012447	ATP binding site [chemical binding]; other site
886293012448	substrate binding site [chemical binding]; other site
886293012449	activation loop (A-loop); other site
886293012450	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
886293012451	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
886293012452	acyl-activating enzyme (AAE) consensus motif; other site
886293012453	AMP binding site [chemical binding]; other site
886293012454	active site
886293012455	CoA binding site [chemical binding]; other site
886293012456	Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459
886293012457	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
886293012458	DNA methylase; Region: N6_N4_Mtase; cl17433
886293012459	YceI-like domain; Region: YceI; cl01001
886293012460	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
886293012461	MarR family; Region: MarR; pfam01047
886293012462	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
886293012463	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293012464	S-adenosylmethionine binding site [chemical binding]; other site
886293012465	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
886293012466	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
886293012467	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
886293012468	active site
886293012469	putative lithium-binding site [ion binding]; other site
886293012470	substrate binding site [chemical binding]; other site
886293012471	GTP-binding protein YchF; Reviewed; Region: PRK09601
886293012472	YchF GTPase; Region: YchF; cd01900
886293012473	G1 box; other site
886293012474	GTP/Mg2+ binding site [chemical binding]; other site
886293012475	Switch I region; other site
886293012476	G2 box; other site
886293012477	Switch II region; other site
886293012478	G3 box; other site
886293012479	G4 box; other site
886293012480	G5 box; other site
886293012481	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
886293012482	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293012483	Protein of unknown function (DUF1587); Region: PSD3; pfam07626
886293012484	Protein of unknown function (DUF1595); Region: PSD5; pfam07637
886293012485	Protein of unknown function (DUF1592); Region: PSD4; pfam07631
886293012486	Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627
886293012487	Protein of unknown function (DUF1585); Region: PSD2; pfam07624
886293012488	Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586
886293012489	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
886293012490	HEAT repeats; Region: HEAT_2; pfam13646
886293012491	HEAT repeats; Region: HEAT_2; pfam13646
886293012492	HEAT repeats; Region: HEAT_2; pfam13646
886293012493	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293012494	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293012495	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293012496	structural tetrad; other site
886293012497	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293012498	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293012499	active site
886293012500	ATP binding site [chemical binding]; other site
886293012501	substrate binding site [chemical binding]; other site
886293012502	activation loop (A-loop); other site
886293012503	RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6
886293012504	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
886293012505	DNA binding residues [nucleotide binding]
886293012506	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293012507	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
886293012508	putative NAD(P) binding site [chemical binding]; other site
886293012509	active site
886293012510	putative substrate binding site [chemical binding]; other site
886293012511	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
886293012512	active site
886293012513	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
886293012514	homodimer interface [polypeptide binding]; other site
886293012515	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
886293012516	polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006
886293012517	putative active site [active]
886293012518	putative catalytic site [active]
886293012519	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
886293012520	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
886293012521	Chain length determinant protein; Region: Wzz; cl15801
886293012522	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
886293012523	Protein of unknown function (DUF3485); Region: DUF3485; cl11827
886293012524	VanZ like family; Region: VanZ; pfam04892
886293012525	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
886293012526	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293012527	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
886293012528	PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063
886293012529	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
886293012530	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
886293012531	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293012532	O-Antigen ligase; Region: Wzy_C; cl04850
886293012533	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
886293012534	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
886293012535	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
886293012536	putative ADP-binding pocket [chemical binding]; other site
886293012537	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
886293012538	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
886293012539	active site
886293012540	dimer interface [polypeptide binding]; other site
886293012541	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
886293012542	Ligand Binding Site [chemical binding]; other site
886293012543	Molecular Tunnel; other site
886293012544	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
886293012545	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
886293012546	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
886293012547	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
886293012548	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293012549	S-adenosylmethionine binding site [chemical binding]; other site
886293012550	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
886293012551	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
886293012552	Acyltransferase family; Region: Acyl_transf_3; pfam01757
886293012553	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
886293012554	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
886293012555	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
886293012556	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
886293012557	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
886293012558	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
886293012559	TPR motif; other site
886293012560	binding surface
886293012561	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293012562	binding surface
886293012563	TPR motif; other site
886293012564	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
886293012565	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293012566	TPR motif; other site
886293012567	binding surface
886293012568	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293012569	TPR motif; other site
886293012570	binding surface
886293012571	TPR repeat; Region: TPR_11; pfam13414
886293012572	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293012573	binding surface
886293012574	TPR motif; other site
886293012575	TPR repeat; Region: TPR_11; pfam13414
886293012576	FHA domain; Region: FHA; pfam00498
886293012577	phosphopeptide binding site; other site
886293012578	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
886293012579	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293012580	phosphopeptide binding site; other site
886293012581	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293012582	active site
886293012583	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293012584	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
886293012585	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
886293012586	Methyltransferase domain; Region: Methyltransf_23; pfam13489
886293012587	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
886293012588	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
886293012589	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
886293012590	substrate binding pocket [chemical binding]; other site
886293012591	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293012592	DDE superfamily endonuclease; Region: DDE_5; pfam13546
886293012593	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
886293012594	Family description; Region: VCBS; pfam13517
886293012595	Family description; Region: VCBS; pfam13517
886293012596	Family description; Region: VCBS; pfam13517
886293012597	Family description; Region: VCBS; pfam13517
886293012598	Family description; Region: VCBS; pfam13517
886293012599	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
886293012600	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293012601	Family description; Region: VCBS; pfam13517
886293012602	Family description; Region: VCBS; pfam13517
886293012603	Family description; Region: VCBS; pfam13517
886293012604	Family description; Region: VCBS; pfam13517
886293012605	Family description; Region: VCBS; pfam13517
886293012606	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
886293012607	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
886293012608	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
886293012609	active site
886293012610	catalytic tetrad [active]
886293012611	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
886293012612	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
886293012613	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293012614	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293012615	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293012616	NAD(P) binding site [chemical binding]; other site
886293012617	active site
886293012618	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293012619	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
886293012620	SmpB-tmRNA interface; other site
886293012621	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
886293012622	catalytic center binding site [active]
886293012623	ATP binding site [chemical binding]; other site
886293012624	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
886293012625	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
886293012626	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293012627	homodimer interface [polypeptide binding]; other site
886293012628	catalytic residue [active]
886293012629	hypothetical protein; Validated; Region: PRK00110
886293012630	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293012631	binding surface
886293012632	TPR motif; other site
886293012633	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293012634	binding surface
886293012635	TPR motif; other site
886293012636	TPR repeat; Region: TPR_11; pfam13414
886293012637	Tetratricopeptide repeat; Region: TPR_16; pfam13432
886293012638	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
886293012639	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293012640	binding surface
886293012641	TPR motif; other site
886293012642	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293012643	TPR motif; other site
886293012644	binding surface
886293012645	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293012646	TPR motif; other site
886293012647	binding surface
886293012648	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
886293012649	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
886293012650	Protein of unknown function (DUF503); Region: DUF503; cl00669
886293012651	translation initiation factor IF-2; Region: IF-2; TIGR00487
886293012652	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
886293012653	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
886293012654	G1 box; other site
886293012655	putative GEF interaction site [polypeptide binding]; other site
886293012656	GTP/Mg2+ binding site [chemical binding]; other site
886293012657	Switch I region; other site
886293012658	G2 box; other site
886293012659	G3 box; other site
886293012660	Switch II region; other site
886293012661	G4 box; other site
886293012662	G5 box; other site
886293012663	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
886293012664	Translation-initiation factor 2; Region: IF-2; pfam11987
886293012665	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
886293012666	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
886293012667	NusA N-terminal domain; Region: NusA_N; pfam08529
886293012668	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
886293012669	RNA binding site [nucleotide binding]; other site
886293012670	homodimer interface [polypeptide binding]; other site
886293012671	NusA-like KH domain; Region: KH_5; pfam13184
886293012672	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
886293012673	G-X-X-G motif; other site
886293012674	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
886293012675	ferric uptake regulator; Provisional; Region: fur; PRK09462
886293012676	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
886293012677	metal binding site 2 [ion binding]; metal-binding site
886293012678	putative DNA binding helix; other site
886293012679	metal binding site 1 [ion binding]; metal-binding site
886293012680	dimer interface [polypeptide binding]; other site
886293012681	structural Zn2+ binding site [ion binding]; other site
886293012682	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
886293012683	active site
886293012684	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
886293012685	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
886293012686	FeS/SAM binding site; other site
886293012687	Peroxiredoxin (PRX) family; composed of the different classes of PRXs including many proteins originally known as bacterioferritin comigratory proteins (BCP), based on their electrophoretic mobility before their function was identified. PRXs are...; Region: PRX_family; cd02971
886293012688	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293012689	catalytic triad [active]
886293012690	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
886293012691	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
886293012692	ATP-grasp domain; Region: ATP-grasp; pfam02222
886293012693	helicase 45; Provisional; Region: PTZ00424
886293012694	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
886293012695	ATP binding site [chemical binding]; other site
886293012696	Mg++ binding site [ion binding]; other site
886293012697	motif III; other site
886293012698	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293012699	nucleotide binding region [chemical binding]; other site
886293012700	ATP-binding site [chemical binding]; other site
886293012701	Oxygen tolerance; Region: BatD; pfam13584
886293012702	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
886293012703	metal ion-dependent adhesion site (MIDAS); other site
886293012704	TPR repeat; Region: TPR_11; pfam13414
886293012705	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293012706	binding surface
886293012707	TPR motif; other site
886293012708	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
886293012709	metal ion-dependent adhesion site (MIDAS); other site
886293012710	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293012711	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293012712	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293012713	DNA binding residues [nucleotide binding]
886293012714	Putative zinc-finger; Region: zf-HC2; pfam13490
886293012715	A new structural DNA glycosylase; Region: AlkD_like; cl11434
886293012716	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293012717	S-adenosylmethionine binding site [chemical binding]; other site
886293012718	RF-1 domain; Region: RF-1; pfam00472
886293012719	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293012720	putative acetyltransferase; Provisional; Region: PRK03624
886293012721	Coenzyme A binding pocket [chemical binding]; other site
886293012722	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
886293012723	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
886293012724	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
886293012725	Ligand binding site; other site
886293012726	Putative Catalytic site; other site
886293012727	DXD motif; other site
886293012728	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
886293012729	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
886293012730	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
886293012731	Soluble P-type ATPase [General function prediction only]; Region: COG4087
886293012732	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
886293012733	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
886293012734	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
886293012735	Ligand Binding Site [chemical binding]; other site
886293012736	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
886293012737	dimerization interface [polypeptide binding]; other site
886293012738	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
886293012739	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293012740	dimer interface [polypeptide binding]; other site
886293012741	phosphorylation site [posttranslational modification]
886293012742	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293012743	ATP binding site [chemical binding]; other site
886293012744	Mg2+ binding site [ion binding]; other site
886293012745	G-X-G motif; other site
886293012746	Response regulator receiver domain; Region: Response_reg; pfam00072
886293012747	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293012748	active site
886293012749	phosphorylation site [posttranslational modification]
886293012750	intermolecular recognition site; other site
886293012751	dimerization interface [polypeptide binding]; other site
886293012752	TPR repeat; Region: TPR_11; pfam13414
886293012753	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293012754	TPR motif; other site
886293012755	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293012756	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293012757	active site
886293012758	phosphorylation site [posttranslational modification]
886293012759	intermolecular recognition site; other site
886293012760	dimerization interface [polypeptide binding]; other site
886293012761	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
886293012762	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
886293012763	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
886293012764	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
886293012765	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
886293012766	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
886293012767	4Fe-4S binding domain; Region: Fer4; pfam00037
886293012768	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
886293012769	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
886293012770	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
886293012771	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
886293012772	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
886293012773	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
886293012774	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
886293012775	hypothetical protein; Provisional; Region: PRK07208
886293012776	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
886293012777	Uncharacterized conserved protein [Function unknown]; Region: COG3375
886293012778	hypothetical protein; Provisional; Region: PRK07338
886293012779	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
886293012780	metal binding site [ion binding]; metal-binding site
886293012781	dimer interface [polypeptide binding]; other site
886293012782	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
886293012783	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
886293012784	active site
886293012785	octamer interface [polypeptide binding]; other site
886293012786	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
886293012787	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
886293012788	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
886293012789	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
886293012790	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
886293012791	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
886293012792	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
886293012793	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
886293012794	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
886293012795	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293012796	active site
886293012797	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
886293012798	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
886293012799	active site
886293012800	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
886293012801	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293012802	active site
886293012803	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
886293012804	phosphate binding site [ion binding]; other site
886293012805	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
886293012806	phosphate binding site [ion binding]; other site
886293012807	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
886293012808	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
886293012809	active site
886293012810	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
886293012811	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
886293012812	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
886293012813	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293012814	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
886293012815	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
886293012816	putative NADP binding site [chemical binding]; other site
886293012817	active site
886293012818	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
886293012819	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
886293012820	active site
886293012821	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
886293012822	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
886293012823	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
886293012824	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
886293012825	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
886293012826	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
886293012827	catalytic site [active]
886293012828	short chain dehydrogenase; Provisional; Region: PRK07024
886293012829	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293012830	NAD(P) binding site [chemical binding]; other site
886293012831	active site
886293012832	Methyltransferase domain; Region: Methyltransf_11; pfam08241
886293012833	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
886293012834	Walker B motif; other site
886293012835	Trm112p-like protein; Region: Trm112p; pfam03966
886293012836	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293012837	S-adenosylmethionine binding site [chemical binding]; other site
886293012838	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
886293012839	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
886293012840	FtsX-like permease family; Region: FtsX; pfam02687
886293012841	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
886293012842	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
886293012843	Walker A/P-loop; other site
886293012844	ATP binding site [chemical binding]; other site
886293012845	Q-loop/lid; other site
886293012846	ABC transporter signature motif; other site
886293012847	Walker B; other site
886293012848	D-loop; other site
886293012849	H-loop/switch region; other site
886293012850	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
886293012851	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293012852	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293012853	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293012854	Predicted peptidase [General function prediction only]; Region: COG4099
886293012855	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
886293012856	Repair protein; Region: Repair_PSII; pfam04536
886293012857	Domain of unknown function (DUF336); Region: DUF336; pfam03928
886293012858	LytB protein; Region: LYTB; cl00507
886293012859	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
886293012860	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
886293012861	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
886293012862	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
886293012863	Domain of unknown function DUF21; Region: DUF21; pfam01595
886293012864	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
886293012865	Transporter associated domain; Region: CorC_HlyC; smart01091
886293012866	ribosome recycling factor; Reviewed; Region: frr; PRK00083
886293012867	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
886293012868	hinge region; other site
886293012869	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
886293012870	putative nucleotide binding site [chemical binding]; other site
886293012871	uridine monophosphate binding site [chemical binding]; other site
886293012872	homohexameric interface [polypeptide binding]; other site
886293012873	elongation factor Ts; Reviewed; Region: tsf; PRK12332
886293012874	Elongation factor TS; Region: EF_TS; pfam00889
886293012875	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
886293012876	rRNA interaction site [nucleotide binding]; other site
886293012877	S8 interaction site; other site
886293012878	putative laminin-1 binding site; other site
886293012879	DNA topoisomerase I; Validated; Region: PRK06599
886293012880	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
886293012881	active site
886293012882	interdomain interaction site; other site
886293012883	putative metal-binding site [ion binding]; other site
886293012884	nucleotide binding site [chemical binding]; other site
886293012885	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
886293012886	domain I; other site
886293012887	DNA binding groove [nucleotide binding]
886293012888	phosphate binding site [ion binding]; other site
886293012889	domain II; other site
886293012890	domain III; other site
886293012891	nucleotide binding site [chemical binding]; other site
886293012892	catalytic site [active]
886293012893	domain IV; other site
886293012894	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
886293012895	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
886293012896	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
886293012897	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
886293012898	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
886293012899	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
886293012900	catalytic residues [active]
886293012901	Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736
886293012902	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
886293012903	Part of AAA domain; Region: AAA_19; pfam13245
886293012904	Family description; Region: UvrD_C_2; pfam13538
886293012905	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
886293012906	active site
886293012907	hydrophilic channel; other site
886293012908	dimerization interface [polypeptide binding]; other site
886293012909	catalytic residues [active]
886293012910	active site lid [active]
886293012911	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
886293012912	dihydrodipicolinate synthase; Region: dapA; TIGR00674
886293012913	dimer interface [polypeptide binding]; other site
886293012914	active site
886293012915	catalytic residue [active]
886293012916	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293012917	dimerization interface [polypeptide binding]; other site
886293012918	putative DNA binding site [nucleotide binding]; other site
886293012919	putative Zn2+ binding site [ion binding]; other site
886293012920	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
886293012921	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
886293012922	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
886293012923	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
886293012924	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
886293012925	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
886293012926	active site
886293012927	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293012928	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293012929	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293012930	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293012931	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293012932	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293012933	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
886293012934	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
886293012935	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
886293012936	inhibitor-cofactor binding pocket; inhibition site
886293012937	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293012938	catalytic residue [active]
886293012939	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
886293012940	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293012941	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293012942	structural tetrad; other site
886293012943	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293012944	structural tetrad; other site
886293012945	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293012946	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293012947	structural tetrad; other site
886293012948	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
886293012949	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
886293012950	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
886293012951	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
886293012952	metal binding site [ion binding]; metal-binding site
886293012953	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
886293012954	active site
886293012955	Calx-beta domain; Region: Calx-beta; pfam03160
886293012956	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
886293012957	active site
886293012958	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
886293012959	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293012960	motif II; other site
886293012961	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
886293012962	Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253
886293012963	NAD(P) binding site [chemical binding]; other site
886293012964	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
886293012965	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
886293012966	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
886293012967	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
886293012968	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
886293012969	substrate binding pocket [chemical binding]; other site
886293012970	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293012971	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
886293012972	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
886293012973	putative dimer interface [polypeptide binding]; other site
886293012974	active site pocket [active]
886293012975	putative cataytic base [active]
886293012976	DinB superfamily; Region: DinB_2; pfam12867
886293012977	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
886293012978	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
886293012979	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
886293012980	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
886293012981	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
886293012982	pteridine reductase; Provisional; Region: PRK09135
886293012983	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293012984	NAD(P) binding site [chemical binding]; other site
886293012985	active site
886293012986	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293012987	Sulfatase; Region: Sulfatase; pfam00884
886293012988	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293012989	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
886293012990	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
886293012991	BNR repeat-like domain; Region: BNR_2; pfam13088
886293012992	catalytic site [active]
886293012993	Asp-box motif; other site
886293012994	TPR repeat; Region: TPR_11; pfam13414
886293012995	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293012996	binding surface
886293012997	TPR motif; other site
886293012998	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
886293012999	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
886293013000	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
886293013001	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
886293013002	Preprotein translocase subunit; Region: YajC; pfam02699
886293013003	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
886293013004	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
886293013005	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
886293013006	Protein export membrane protein; Region: SecD_SecF; pfam02355
886293013007	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
886293013008	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
886293013009	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
886293013010	putative active site [active]
886293013011	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293013012	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293013013	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
886293013014	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
886293013015	putative dimer interface [polypeptide binding]; other site
886293013016	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
886293013017	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
886293013018	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293013019	active site
886293013020	phosphorylation site [posttranslational modification]
886293013021	intermolecular recognition site; other site
886293013022	dimerization interface [polypeptide binding]; other site
886293013023	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
886293013024	dimerization interface [polypeptide binding]; other site
886293013025	DNA binding residues [nucleotide binding]
886293013026	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293013027	Sulfatase; Region: Sulfatase; cl17466
886293013028	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293013029	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293013030	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293013031	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293013032	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
886293013033	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293013034	RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989
886293013035	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293013036	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293013037	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293013038	active site
886293013039	ATP binding site [chemical binding]; other site
886293013040	substrate binding site [chemical binding]; other site
886293013041	activation loop (A-loop); other site
886293013042	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
886293013043	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
886293013044	active site
886293013045	catalytic tetrad [active]
886293013046	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
886293013047	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
886293013048	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
886293013049	Low molecular weight phosphatase family; Region: LMWPc; cd00115
886293013050	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
886293013051	active site
886293013052	Protein of unknown function (DUF493); Region: DUF493; pfam04359
886293013053	Response regulator receiver domain; Region: Response_reg; pfam00072
886293013054	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293013055	active site
886293013056	phosphorylation site [posttranslational modification]
886293013057	intermolecular recognition site; other site
886293013058	dimerization interface [polypeptide binding]; other site
886293013059	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
886293013060	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
886293013061	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
886293013062	active site residue [active]
886293013063	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293013064	Family description; Region: VCBS; pfam13517
886293013065	Family description; Region: VCBS; pfam13517
886293013066	Family description; Region: VCBS; pfam13517
886293013067	Family description; Region: VCBS; pfam13517
886293013068	xylose isomerase; Provisional; Region: PRK05474
886293013069	xylose isomerase; Region: xylose_isom_A; TIGR02630
886293013070	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
886293013071	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293013072	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
886293013073	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
886293013074	active site
886293013075	putative substrate binding pocket [chemical binding]; other site
886293013076	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293013077	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
886293013078	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
886293013079	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
886293013080	catalytic residue [active]
886293013081	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
886293013082	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
886293013083	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
886293013084	hinge; other site
886293013085	active site
886293013086	Peptidase family M28; Region: Peptidase_M28; pfam04389
886293013087	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
886293013088	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
886293013089	dimer interface [polypeptide binding]; other site
886293013090	anticodon binding site; other site
886293013091	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
886293013092	homodimer interface [polypeptide binding]; other site
886293013093	motif 1; other site
886293013094	active site
886293013095	motif 2; other site
886293013096	GAD domain; Region: GAD; pfam02938
886293013097	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
886293013098	active site
886293013099	motif 3; other site
886293013100	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
886293013101	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
886293013102	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
886293013103	nudix motif; other site
886293013104	ACT domain-containing protein [General function prediction only]; Region: COG4747
886293013105	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
886293013106	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
886293013107	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293013108	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293013109	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293013110	structural tetrad; other site
886293013111	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
886293013112	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293013113	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293013114	quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908
886293013115	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293013116	leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411
886293013117	Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599
886293013118	active site
886293013119	Zn binding site [ion binding]; other site
886293013120	Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127
886293013121	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
886293013122	substrate binding site [chemical binding]; other site
886293013123	methionine synthase; Provisional; Region: PRK01207
886293013124	THF binding site; other site
886293013125	zinc-binding site [ion binding]; other site
886293013126	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293013127	putative cation:proton antiport protein; Provisional; Region: PRK10669
886293013128	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
886293013129	TrkA-N domain; Region: TrkA_N; pfam02254
886293013130	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
886293013131	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
886293013132	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
886293013133	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
886293013134	D-xylulose kinase; Region: XylB; TIGR01312
886293013135	N- and C-terminal domain interface [polypeptide binding]; other site
886293013136	active site
886293013137	MgATP binding site [chemical binding]; other site
886293013138	catalytic site [active]
886293013139	metal binding site [ion binding]; metal-binding site
886293013140	xylulose binding site [chemical binding]; other site
886293013141	homodimer interface [polypeptide binding]; other site
886293013142	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
886293013143	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
886293013144	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293013145	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293013146	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293013147	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293013148	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
886293013149	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
886293013150	G1 box; other site
886293013151	putative GEF interaction site [polypeptide binding]; other site
886293013152	GTP/Mg2+ binding site [chemical binding]; other site
886293013153	Switch I region; other site
886293013154	G2 box; other site
886293013155	G3 box; other site
886293013156	Switch II region; other site
886293013157	G4 box; other site
886293013158	G5 box; other site
886293013159	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
886293013160	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
886293013161	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
886293013162	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
886293013163	Ligand binding site; other site
886293013164	Putative Catalytic site; other site
886293013165	DXD motif; other site
886293013166	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293013167	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
886293013168	AP (apurinic/apyrimidinic) site pocket; other site
886293013169	DNA interaction; other site
886293013170	Metal-binding active site; metal-binding site
886293013171	rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239
886293013172	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
886293013173	Rhomboid family; Region: Rhomboid; pfam01694
886293013174	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
886293013175	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
886293013176	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
886293013177	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
886293013178	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293013179	HEAT repeats; Region: HEAT_2; pfam13646
886293013180	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293013181	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
886293013182	FecR protein; Region: FecR; pfam04773
886293013183	RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989
886293013184	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293013185	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293013186	DNA binding residues [nucleotide binding]
886293013187	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293013188	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293013189	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293013190	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
886293013191	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293013192	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293013193	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
886293013194	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293013195	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293013196	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293013197	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293013198	Cytochrome c; Region: Cytochrom_C; cl11414
886293013199	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293013200	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
886293013201	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
886293013202	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293013203	Sulfatase; Region: Sulfatase; pfam00884
886293013204	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293013205	Sulfatase; Region: Sulfatase; pfam00884
886293013206	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
886293013207	active site
886293013208	catalytic triad [active]
886293013209	oxyanion hole [active]
886293013210	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
886293013211	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
886293013212	trimer interface [polypeptide binding]; other site
886293013213	putative metal binding site [ion binding]; other site
886293013214	Glucose dehydrogenase; Region: glucose_DH; cd08230
886293013215	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
886293013216	NADP binding site [chemical binding]; other site
886293013217	catalytic Zn binding site [ion binding]; other site
886293013218	structural Zn binding site [ion binding]; other site
886293013219	dimer interface [polypeptide binding]; other site
886293013220	Cupin domain; Region: Cupin_2; cl17218
886293013221	Opioid growth factor receptor (OGFr) conserved region; Region: OGFr_N; pfam04664
886293013222	Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900
886293013223	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
886293013224	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293013225	S-adenosylmethionine binding site [chemical binding]; other site
886293013226	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
886293013227	anti sigma factor interaction site; other site
886293013228	regulatory phosphorylation site [posttranslational modification]; other site
886293013229	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
886293013230	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
886293013231	active site
886293013232	catalytic tetrad [active]
886293013233	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
886293013234	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293013235	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
886293013236	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293013237	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
886293013238	Protein export membrane protein; Region: SecD_SecF; cl14618
886293013239	Predicted transcriptional regulator [Transcription]; Region: COG1959
886293013240	Transcriptional regulator; Region: Rrf2; pfam02082
886293013241	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293013242	HEAT repeats; Region: HEAT_2; pfam13646
886293013243	HEAT repeats; Region: HEAT_2; pfam13646
886293013244	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293013245	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
886293013246	Beta-lactamase; Region: Beta-lactamase; pfam00144
886293013247	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
886293013248	Domain of unknown function (DUF3472); Region: DUF3472; pfam11958
886293013249	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
886293013250	active site
886293013251	catalytic triad [active]
886293013252	oxyanion hole [active]
886293013253	Repair protein; Region: Repair_PSII; pfam04536
886293013254	Repair protein; Region: Repair_PSII; pfam04536
886293013255	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
886293013256	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293013257	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
886293013258	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
886293013259	FtsX-like permease family; Region: FtsX; pfam02687
886293013260	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
886293013261	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293013262	dimer interface [polypeptide binding]; other site
886293013263	phosphorylation site [posttranslational modification]
886293013264	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293013265	ATP binding site [chemical binding]; other site
886293013266	Mg2+ binding site [ion binding]; other site
886293013267	G-X-G motif; other site
886293013268	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
886293013269	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293013270	active site
886293013271	phosphorylation site [posttranslational modification]
886293013272	intermolecular recognition site; other site
886293013273	dimerization interface [polypeptide binding]; other site
886293013274	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
886293013275	DNA binding residues [nucleotide binding]
886293013276	dimerization interface [polypeptide binding]; other site
886293013277	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
886293013278	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
886293013279	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
886293013280	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
886293013281	[4Fe-4S] binding site [ion binding]; other site
886293013282	molybdopterin cofactor binding site; other site
886293013283	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
886293013284	molybdopterin cofactor binding site; other site
886293013285	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
886293013286	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293013287	putative substrate translocation pore; other site
886293013288	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567
886293013289	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
886293013290	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
886293013291	sulfite reductase; Provisional; Region: PRK06214
886293013292	Putative Fe-S cluster; Region: FeS; cl17515
886293013293	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
886293013294	FAD binding pocket [chemical binding]; other site
886293013295	FAD binding motif [chemical binding]; other site
886293013296	catalytic residues [active]
886293013297	NAD binding pocket [chemical binding]; other site
886293013298	phosphate binding motif [ion binding]; other site
886293013299	beta-alpha-beta structure motif; other site
886293013300	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
886293013301	Found in ATP-dependent protease La (LON); Region: LON; smart00464
886293013302	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293013303	Walker A motif; other site
886293013304	ATP binding site [chemical binding]; other site
886293013305	Walker B motif; other site
886293013306	arginine finger; other site
886293013307	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
886293013308	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
886293013309	beta-phosphoglucomutase; Region: bPGM; TIGR01990
886293013310	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
886293013311	motif II; other site
886293013312	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293013313	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
886293013314	Metal-binding active site; metal-binding site
886293013315	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
886293013316	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293013317	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
886293013318	DNA binding residues [nucleotide binding]
886293013319	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819
886293013320	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
886293013321	dimer interface [polypeptide binding]; other site
886293013322	active site
886293013323	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
886293013324	substrate binding site [chemical binding]; other site
886293013325	catalytic residue [active]
886293013326	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293013327	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293013328	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293013329	Predicted acyl esterases [General function prediction only]; Region: COG2936
886293013330	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293013331	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
886293013332	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293013333	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293013334	prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294
886293013335	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293013336	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293013337	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
886293013338	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
886293013339	putative acyl-acceptor binding pocket; other site
886293013340	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293013341	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293013342	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293013343	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
886293013344	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
886293013345	active site
886293013346	HIGH motif; other site
886293013347	dimer interface [polypeptide binding]; other site
886293013348	KMSKS motif; other site
886293013349	CAAX protease self-immunity; Region: Abi; pfam02517
886293013350	Right handed beta helix region; Region: Beta_helix; pfam13229
886293013351	Domain of unknown function DUF11; Region: DUF11; pfam01345
886293013352	Domain of unknown function DUF11; Region: DUF11; pfam01345
886293013353	Domain of unknown function DUF11; Region: DUF11; pfam01345
886293013354	Domain of unknown function DUF11; Region: DUF11; pfam01345
886293013355	Domain of unknown function DUF11; Region: DUF11; pfam01345
886293013356	Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237
886293013357	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
886293013358	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
886293013359	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293013360	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293013361	DNA binding residues [nucleotide binding]
886293013362	Cytochrome c; Region: Cytochrom_C; pfam00034
886293013363	PA14 domain; Region: PA14; cl08459
886293013364	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
886293013365	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293013366	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293013367	active site
886293013368	ATP binding site [chemical binding]; other site
886293013369	substrate binding site [chemical binding]; other site
886293013370	activation loop (A-loop); other site
886293013371	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
886293013372	Uncharacterized conserved protein [Function unknown]; Region: COG2308
886293013373	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
886293013374	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
886293013375	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
886293013376	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
886293013377	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
886293013378	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
886293013379	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
886293013380	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
886293013381	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
886293013382	active site
886293013383	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
886293013384	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
886293013385	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
886293013386	putative active site [active]
886293013387	putative NTP binding site [chemical binding]; other site
886293013388	putative nucleic acid binding site [nucleotide binding]; other site
886293013389	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
886293013390	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
886293013391	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
886293013392	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293013393	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
886293013394	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
886293013395	putative NAD(P) binding site [chemical binding]; other site
886293013396	putative substrate binding site [chemical binding]; other site
886293013397	catalytic Zn binding site [ion binding]; other site
886293013398	structural Zn binding site [ion binding]; other site
886293013399	dimer interface [polypeptide binding]; other site
886293013400	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
886293013401	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
886293013402	active site
886293013403	catalytic tetrad [active]
886293013404	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
886293013405	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
886293013406	putative NAD(P) binding site [chemical binding]; other site
886293013407	putative substrate binding site [chemical binding]; other site
886293013408	catalytic Zn binding site [ion binding]; other site
886293013409	structural Zn binding site [ion binding]; other site
886293013410	dimer interface [polypeptide binding]; other site
886293013411	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
886293013412	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
886293013413	active site
886293013414	catalytic tetrad [active]
886293013415	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
886293013416	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
886293013417	active site
886293013418	dimerization interface [polypeptide binding]; other site
886293013419	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
886293013420	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293013421	putative substrate translocation pore; other site
886293013422	short chain dehydrogenase; Provisional; Region: PRK06197
886293013423	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
886293013424	putative NAD(P) binding site [chemical binding]; other site
886293013425	active site
886293013426	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293013427	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
886293013428	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
886293013429	Radical SAM superfamily; Region: Radical_SAM; pfam04055
886293013430	FeS/SAM binding site; other site
886293013431	Uncharacterized conserved protein [Function unknown]; Region: COG1556
886293013432	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
886293013433	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
886293013434	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
886293013435	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
886293013436	Cysteine-rich domain; Region: CCG; pfam02754
886293013437	Cysteine-rich domain; Region: CCG; pfam02754
886293013438	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293013439	Protein of unknown function (DUF1574); Region: DUF1574; pfam07611
886293013440	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
886293013441	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
886293013442	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
886293013443	active site
886293013444	metal binding site [ion binding]; metal-binding site
886293013445	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
886293013446	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
886293013447	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
886293013448	ABC transporter; Region: ABC_tran_2; pfam12848
886293013449	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
886293013450	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
886293013451	GIY-YIG motif/motif A; other site
886293013452	active site
886293013453	catalytic site [active]
886293013454	putative DNA binding site [nucleotide binding]; other site
886293013455	metal binding site [ion binding]; metal-binding site
886293013456	UvrB/uvrC motif; Region: UVR; pfam02151
886293013457	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
886293013458	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
886293013459	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
886293013460	active site
886293013461	substrate binding site [chemical binding]; other site
886293013462	metal binding site [ion binding]; metal-binding site
886293013463	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293013464	Major Facilitator Superfamily; Region: MFS_1; pfam07690
886293013465	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
886293013466	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293013467	Lipase (class 2); Region: Lipase_2; pfam01674
886293013468	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
886293013469	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293013470	putative substrate translocation pore; other site
886293013471	POT family; Region: PTR2; cl17359
886293013472	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
886293013473	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
886293013474	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
886293013475	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293013476	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
886293013477	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
886293013478	Potassium binding sites [ion binding]; other site
886293013479	Cesium cation binding sites [ion binding]; other site
886293013480	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
886293013481	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
886293013482	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
886293013483	active site
886293013484	catalytic tetrad [active]
886293013485	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
886293013486	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
886293013487	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
886293013488	Uncharacterized conserved protein [Function unknown]; Region: COG2006
886293013489	Domain of unknown function (DUF362); Region: DUF362; pfam04015
886293013490	4Fe-4S binding domain; Region: Fer4_5; pfam12801
886293013491	4Fe-4S binding domain; Region: Fer4_5; pfam12801
886293013492	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
886293013493	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
886293013494	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
886293013495	4Fe-4S binding domain; Region: Fer4; pfam00037
886293013496	C-terminal peptidase (prc); Region: prc; TIGR00225
886293013497	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
886293013498	protein binding site [polypeptide binding]; other site
886293013499	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
886293013500	Catalytic dyad [active]
886293013501	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
886293013502	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
886293013503	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
886293013504	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
886293013505	catalytic site [active]
886293013506	active site
886293013507	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
886293013508	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
886293013509	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
886293013510	active site
886293013511	catalytic site [active]
886293013512	trehalose synthase; Region: treS_nterm; TIGR02456
886293013513	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
886293013514	active site
886293013515	catalytic site [active]
886293013516	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
886293013517	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
886293013518	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
886293013519	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
886293013520	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
886293013521	active site
886293013522	homodimer interface [polypeptide binding]; other site
886293013523	catalytic site [active]
886293013524	acceptor binding site [chemical binding]; other site
886293013525	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
886293013526	ApbE family; Region: ApbE; pfam02424
886293013527	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
886293013528	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
886293013529	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
886293013530	Predicted PP-loop superfamily ATPase [General function prediction only]; Region: COG0603
886293013531	Ligand Binding Site [chemical binding]; other site
886293013532	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
886293013533	active site
886293013534	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
886293013535	Protein of unknown function, DUF488; Region: DUF488; pfam04343
886293013536	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
886293013537	Strictosidine synthase; Region: Str_synth; pfam03088
886293013538	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293013539	Tetratricopeptide repeat; Region: TPR_16; pfam13432
886293013540	TPR motif; other site
886293013541	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
886293013542	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
886293013543	catalytic triad [active]
886293013544	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
886293013545	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293013546	NAD(P) binding site [chemical binding]; other site
886293013547	active site
886293013548	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
886293013549	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293013550	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293013551	DNA binding residues [nucleotide binding]
886293013552	Putative zinc-finger; Region: zf-HC2; pfam13490
886293013553	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
886293013554	tandem repeat interface [polypeptide binding]; other site
886293013555	oligomer interface [polypeptide binding]; other site
886293013556	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
886293013557	active site residues [active]
886293013558	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
886293013559	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
886293013560	Mg++ binding site [ion binding]; other site
886293013561	putative catalytic motif [active]
886293013562	substrate binding site [chemical binding]; other site
886293013563	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
886293013564	Chain length determinant protein; Region: Wzz; cl15801
886293013565	Chain length determinant protein; Region: Wzz; cl15801
886293013566	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
886293013567	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
886293013568	P-loop; other site
886293013569	Magnesium ion binding site [ion binding]; other site
886293013570	O-Antigen ligase; Region: Wzy_C; pfam04932
886293013571	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
886293013572	Protein of unknown function (DUF3485); Region: DUF3485; pfam11984
886293013573	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
886293013574	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
886293013575	NADP-binding site; other site
886293013576	homotetramer interface [polypeptide binding]; other site
886293013577	substrate binding site [chemical binding]; other site
886293013578	homodimer interface [polypeptide binding]; other site
886293013579	active site
886293013580	Uncharacterized conserved protein [Function unknown]; Region: COG3379
886293013581	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
886293013582	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
886293013583	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293013584	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293013585	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
886293013586	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
886293013587	putative metal binding site; other site
886293013588	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293013589	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
886293013590	putative ADP-binding pocket [chemical binding]; other site
886293013591	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293013592	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293013593	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293013594	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293013595	MoxR-like ATPases [General function prediction only]; Region: COG0714
886293013596	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293013597	Walker A motif; other site
886293013598	ATP binding site [chemical binding]; other site
886293013599	Walker B motif; other site
886293013600	arginine finger; other site
886293013601	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
886293013602	Protein of unknown function DUF58; Region: DUF58; pfam01882
886293013603	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
886293013604	RNase P subunit p30; Region: RNase_P_p30; cl03389
886293013605	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
886293013606	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
886293013607	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
886293013608	GTP-binding protein YchF; Reviewed; Region: PRK09601
886293013609	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
886293013610	G1 box; other site
886293013611	GTP/Mg2+ binding site [chemical binding]; other site
886293013612	G2 box; other site
886293013613	Switch I region; other site
886293013614	G3 box; other site
886293013615	Switch II region; other site
886293013616	G5 box; other site
886293013617	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
886293013618	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
886293013619	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
886293013620	pyruvate carboxylase; Reviewed; Region: PRK12999
886293013621	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
886293013622	ATP-grasp domain; Region: ATP-grasp_4; cl17255
886293013623	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
886293013624	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
886293013625	active site
886293013626	catalytic residues [active]
886293013627	metal binding site [ion binding]; metal-binding site
886293013628	homodimer binding site [polypeptide binding]; other site
886293013629	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
886293013630	carboxyltransferase (CT) interaction site; other site
886293013631	biotinylation site [posttranslational modification]; other site
886293013632	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
886293013633	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
886293013634	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
886293013635	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
886293013636	Integrase core domain; Region: rve; pfam00665
886293013637	transposase/IS protein; Provisional; Region: PRK09183
886293013638	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293013639	Walker A motif; other site
886293013640	ATP binding site [chemical binding]; other site
886293013641	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
886293013642	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293013643	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293013644	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293013645	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293013646	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293013647	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293013648	structural tetrad; other site
886293013649	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
886293013650	Leucine-rich repeats; other site
886293013651	Substrate binding site [chemical binding]; other site
886293013652	Leucine rich repeat; Region: LRR_8; pfam13855
886293013653	DDE superfamily endonuclease; Region: DDE_5; pfam13546
886293013654	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
886293013655	Leucine-rich repeats; other site
886293013656	Substrate binding site [chemical binding]; other site
886293013657	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
886293013658	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
886293013659	Phosphotransferase enzyme family; Region: APH; pfam01636
886293013660	active site
886293013661	substrate binding site [chemical binding]; other site
886293013662	ATP binding site [chemical binding]; other site
886293013663	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
886293013664	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
886293013665	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293013666	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
886293013667	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
886293013668	DDE superfamily endonuclease; Region: DDE_3; pfam13358
886293013669	Winged helix-turn helix; Region: HTH_29; pfam13551
886293013670	Homeodomain-like domain; Region: HTH_23; pfam13384
886293013671	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
886293013672	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
886293013673	catalytic residues [active]
886293013674	catalytic nucleophile [active]
886293013675	Recombinase; Region: Recombinase; pfam07508
886293013676	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
886293013677	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
886293013678	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
886293013679	FeS/SAM binding site; other site
886293013680	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
886293013681	Bacitracin resistance protein BacA; Region: BacA; pfam02673
886293013682	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
886293013683	Part of AAA domain; Region: AAA_19; pfam13245
886293013684	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
886293013685	Family description; Region: UvrD_C_2; pfam13538
886293013686	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
886293013687	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
886293013688	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
886293013689	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293013690	S-adenosylmethionine binding site [chemical binding]; other site
886293013691	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
886293013692	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
886293013693	active site
886293013694	NTP binding site [chemical binding]; other site
886293013695	metal binding triad [ion binding]; metal-binding site
886293013696	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
886293013697	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
886293013698	Zn2+ binding site [ion binding]; other site
886293013699	Mg2+ binding site [ion binding]; other site
886293013700	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
886293013701	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293013702	argininosuccinate synthase; Provisional; Region: PRK13820
886293013703	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
886293013704	ANP binding site [chemical binding]; other site
886293013705	Substrate Binding Site II [chemical binding]; other site
886293013706	Substrate Binding Site I [chemical binding]; other site
886293013707	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
886293013708	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
886293013709	active site
886293013710	aspartate kinase; Provisional; Region: PRK07431
886293013711	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
886293013712	putative nucleotide binding site [chemical binding]; other site
886293013713	putative catalytic residues [active]
886293013714	putative Mg ion binding site [ion binding]; other site
886293013715	putative aspartate binding site [chemical binding]; other site
886293013716	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
886293013717	putative allosteric regulatory site; other site
886293013718	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
886293013719	putative allosteric regulatory residue; other site
886293013720	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
886293013721	putative allosteric regulatory site; other site
886293013722	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
886293013723	putative allosteric regulatory residue; other site
886293013724	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
886293013725	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
886293013726	homoserine dehydrogenase; Provisional; Region: PRK06349
886293013727	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
886293013728	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
886293013729	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
886293013730	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
886293013731	Peptidase family U32; Region: Peptidase_U32; pfam01136
886293013732	Collagenase; Region: DUF3656; pfam12392
886293013733	Peptidase family U32; Region: Peptidase_U32; cl03113
886293013734	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
886293013735	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
886293013736	Walker A/P-loop; other site
886293013737	ATP binding site [chemical binding]; other site
886293013738	Q-loop/lid; other site
886293013739	ABC transporter signature motif; other site
886293013740	Walker B; other site
886293013741	D-loop; other site
886293013742	H-loop/switch region; other site
886293013743	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
886293013744	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
886293013745	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
886293013746	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
886293013747	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
886293013748	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
886293013749	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
886293013750	active site
886293013751	catalytic residues [active]
886293013752	metal binding site [ion binding]; metal-binding site
886293013753	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
886293013754	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
886293013755	putative active site [active]
886293013756	substrate binding site [chemical binding]; other site
886293013757	putative cosubstrate binding site; other site
886293013758	catalytic site [active]
886293013759	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
886293013760	substrate binding site [chemical binding]; other site
886293013761	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
886293013762	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
886293013763	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
886293013764	FeS/SAM binding site; other site
886293013765	TRAM domain; Region: TRAM; pfam01938
886293013766	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
886293013767	Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391
886293013768	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
886293013769	metal binding triad; other site
886293013770	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
886293013771	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
886293013772	metal binding triad; other site
886293013773	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
886293013774	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
886293013775	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
886293013776	dimerization interface [polypeptide binding]; other site
886293013777	ligand binding site [chemical binding]; other site
886293013778	NADP binding site [chemical binding]; other site
886293013779	catalytic site [active]
886293013780	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
886293013781	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
886293013782	Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586
886293013783	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293013784	Protein of unknown function (DUF1587); Region: PSD3; pfam07626
886293013785	Protein of unknown function (DUF1595); Region: PSD5; pfam07637
886293013786	Protein of unknown function (DUF1592); Region: PSD4; pfam07631
886293013787	Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627
886293013788	Protein of unknown function (DUF1585); Region: PSD2; pfam07624
886293013789	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293013790	Sulfatase; Region: Sulfatase; pfam00884
886293013791	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
886293013792	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293013793	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
886293013794	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293013795	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
886293013796	Copper type II ascorbate-dependent monooxygenase, N-terminal domain; Region: Cu2_monooxygen; pfam01082
886293013797	Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712
886293013798	ZIP Zinc transporter; Region: Zip; pfam02535
886293013799	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
886293013800	aromatic arch; other site
886293013801	DCoH dimer interaction site [polypeptide binding]; other site
886293013802	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
886293013803	DCoH tetramer interaction site [polypeptide binding]; other site
886293013804	substrate binding site [chemical binding]; other site
886293013805	Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137
886293013806	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
886293013807	ATP binding site [chemical binding]; other site
886293013808	active site
886293013809	substrate binding site [chemical binding]; other site
886293013810	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
886293013811	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
886293013812	Tetramer interface [polypeptide binding]; other site
886293013813	active site
886293013814	FMN-binding site [chemical binding]; other site
886293013815	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
886293013816	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293013817	recombinase A; Provisional; Region: recA; PRK09354
886293013818	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
886293013819	hexamer interface [polypeptide binding]; other site
886293013820	Walker A motif; other site
886293013821	ATP binding site [chemical binding]; other site
886293013822	Walker B motif; other site
886293013823	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
886293013824	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
886293013825	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
886293013826	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
886293013827	substrate binding site [chemical binding]; other site
886293013828	ATP binding site [chemical binding]; other site
886293013829	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
886293013830	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
886293013831	HIGH motif; other site
886293013832	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
886293013833	active site
886293013834	KMSKS motif; other site
886293013835	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293013836	Protein kinase domain; Region: Pkinase; pfam00069
886293013837	active site
886293013838	ATP binding site [chemical binding]; other site
886293013839	substrate binding site [chemical binding]; other site
886293013840	activation loop (A-loop); other site
886293013841	Response regulator receiver domain; Region: Response_reg; pfam00072
886293013842	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293013843	active site
886293013844	phosphorylation site [posttranslational modification]
886293013845	intermolecular recognition site; other site
886293013846	dimerization interface [polypeptide binding]; other site
886293013847	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
886293013848	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
886293013849	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
886293013850	catalytic triad [active]
886293013851	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
886293013852	active site
886293013853	SAM binding site [chemical binding]; other site
886293013854	homodimer interface [polypeptide binding]; other site
886293013855	GTP-binding protein Der; Reviewed; Region: PRK00093
886293013856	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
886293013857	G1 box; other site
886293013858	GTP/Mg2+ binding site [chemical binding]; other site
886293013859	Switch I region; other site
886293013860	G2 box; other site
886293013861	Switch II region; other site
886293013862	G3 box; other site
886293013863	G4 box; other site
886293013864	G5 box; other site
886293013865	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
886293013866	G1 box; other site
886293013867	GTP/Mg2+ binding site [chemical binding]; other site
886293013868	Switch I region; other site
886293013869	G2 box; other site
886293013870	G3 box; other site
886293013871	Switch II region; other site
886293013872	G4 box; other site
886293013873	G5 box; other site
886293013874	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293013875	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
886293013876	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293013877	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
886293013878	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293013879	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293013880	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293013881	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293013882	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293013883	DNA binding residues [nucleotide binding]
886293013884	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293013885	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293013886	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293013887	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293013888	DNA binding residues [nucleotide binding]
886293013889	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293013890	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293013891	catalytic residues [active]
886293013892	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293013893	Sulfatase; Region: Sulfatase; cl17466
886293013894	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
886293013895	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
886293013896	NAD(P) binding site [chemical binding]; other site
886293013897	catalytic residues [active]
886293013898	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
886293013899	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
886293013900	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293013901	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
886293013902	Na binding site [ion binding]; other site
886293013903	Uncharacterized conserved protein [Function unknown]; Region: COG5476
886293013904	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
886293013905	MlrC C-terminus; Region: MlrC_C; pfam07171
886293013906	Predicted amidohydrolase [General function prediction only]; Region: COG0388
886293013907	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
886293013908	active site
886293013909	catalytic triad [active]
886293013910	dimer interface [polypeptide binding]; other site
886293013911	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
886293013912	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
886293013913	active site
886293013914	catalytic triad [active]
886293013915	oxyanion hole [active]
886293013916	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293013917	Sulfatase; Region: Sulfatase; cl17466
886293013918	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293013919	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293013920	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293013921	Tetratricopeptide repeat; Region: TPR_12; pfam13424
886293013922	TPR repeat; Region: TPR_11; pfam13414
886293013923	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293013924	TPR motif; other site
886293013925	binding surface
886293013926	TPR repeat; Region: TPR_11; pfam13414
886293013927	Tetratricopeptide repeat; Region: TPR_1; pfam00515
886293013928	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
886293013929	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
886293013930	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
886293013931	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293013932	NAD(P) binding site [chemical binding]; other site
886293013933	active site
886293013934	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
886293013935	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
886293013936	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
886293013937	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
886293013938	Walker A/P-loop; other site
886293013939	ATP binding site [chemical binding]; other site
886293013940	Q-loop/lid; other site
886293013941	ABC transporter signature motif; other site
886293013942	Walker B; other site
886293013943	D-loop; other site
886293013944	H-loop/switch region; other site
886293013945	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
886293013946	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
886293013947	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
886293013948	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
886293013949	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
886293013950	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
886293013951	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
886293013952	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
886293013953	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293013954	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
886293013955	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293013956	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
886293013957	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
886293013958	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
886293013959	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
886293013960	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
886293013961	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
886293013962	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
886293013963	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
886293013964	catalytic loop [active]
886293013965	iron binding site [ion binding]; other site
886293013966	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
886293013967	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
886293013968	MgtE intracellular N domain; Region: MgtE_N; pfam03448
886293013969	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
886293013970	Divalent cation transporter; Region: MgtE; pfam01769
886293013971	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293013972	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
886293013973	putative transposase OrfB; Reviewed; Region: PHA02517
886293013974	Integrase core domain; Region: rve; pfam00665
886293013975	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
886293013976	SEC-C motif; Region: SEC-C; pfam02810
886293013977	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293013978	Protein of unknown function (DUF952); Region: DUF952; pfam06108
886293013979	Homeodomain-like domain; Region: HTH_23; pfam13384
886293013980	Winged helix-turn helix; Region: HTH_29; pfam13551
886293013981	Homeodomain-like domain; Region: HTH_32; pfam13565
886293013982	DDE superfamily endonuclease; Region: DDE_3; pfam13358
886293013983	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
886293013984	Protein of unknown function (DUF952); Region: DUF952; pfam06108
886293013985	Domain of unknown function (DUF4291); Region: DUF4291; pfam14124
886293013986	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293013987	Coenzyme A binding pocket [chemical binding]; other site
886293013988	putative transposase OrfB; Reviewed; Region: PHA02517
886293013989	HTH-like domain; Region: HTH_21; pfam13276
886293013990	Integrase core domain; Region: rve; pfam00665
886293013991	Integrase core domain; Region: rve_3; pfam13683
886293013992	Bifunctional nuclease; Region: DNase-RNase; pfam02577
886293013993	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
886293013994	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
886293013995	active site
886293013996	HIGH motif; other site
886293013997	nucleotide binding site [chemical binding]; other site
886293013998	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
886293013999	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
886293014000	active site
886293014001	KMSKS motif; other site
886293014002	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
886293014003	tRNA binding surface [nucleotide binding]; other site
886293014004	anticodon binding site; other site
886293014005	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
886293014006	Protein of unknown function (DUF664); Region: DUF664; pfam04978
886293014007	DinB superfamily; Region: DinB_2; pfam12867
886293014008	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
886293014009	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
886293014010	active site
886293014011	catalytic residues [active]
886293014012	metal binding site [ion binding]; metal-binding site
886293014013	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
886293014014	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
886293014015	active site
886293014016	Fe-S cluster binding site [ion binding]; other site
886293014017	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
886293014018	Penicillinase repressor; Region: Pencillinase_R; pfam03965
886293014019	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
886293014020	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
886293014021	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
886293014022	putative dimer interface [polypeptide binding]; other site
886293014023	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
886293014024	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
886293014025	putative dimer interface [polypeptide binding]; other site
886293014026	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
886293014027	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
886293014028	putative dimer interface [polypeptide binding]; other site
886293014029	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293014030	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293014031	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293014032	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293014033	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
886293014034	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
886293014035	Right handed beta helix region; Region: Beta_helix; pfam13229
886293014036	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
886293014037	active site
886293014038	SAM binding site [chemical binding]; other site
886293014039	homodimer interface [polypeptide binding]; other site
886293014040	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
886293014041	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
886293014042	active site
886293014043	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
886293014044	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
886293014045	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
886293014046	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
886293014047	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
886293014048	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
886293014049	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293014050	active site
886293014051	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
886293014052	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
886293014053	CAAX protease self-immunity; Region: Abi; pfam02517
886293014054	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
886293014055	ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266
886293014056	Walker A/P-loop; other site
886293014057	ATP binding site [chemical binding]; other site
886293014058	Q-loop/lid; other site
886293014059	ABC transporter signature motif; other site
886293014060	Walker B; other site
886293014061	D-loop; other site
886293014062	H-loop/switch region; other site
886293014063	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
886293014064	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
886293014065	phosphoethanolamine transferase; Provisional; Region: PRK11560
886293014066	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
886293014067	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
886293014068	Walker A/P-loop; other site
886293014069	ATP binding site [chemical binding]; other site
886293014070	Q-loop/lid; other site
886293014071	ABC transporter signature motif; other site
886293014072	Walker B; other site
886293014073	D-loop; other site
886293014074	H-loop/switch region; other site
886293014075	two component system sensor kinase SsrB; Provisional; Region: PRK15369
886293014076	DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298
886293014077	glutamine synthetase, type I; Region: GlnA; TIGR00653
886293014078	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
886293014079	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
886293014080	Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597
886293014081	lipoprotein signal peptidase; Provisional; Region: PRK14787
886293014082	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
886293014083	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
886293014084	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293014085	NAD(P) binding site [chemical binding]; other site
886293014086	active site
886293014087	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
886293014088	intracellular protease, PfpI family; Region: PfpI; TIGR01382
886293014089	proposed catalytic triad [active]
886293014090	conserved cys residue [active]
886293014091	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293014092	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293014093	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
886293014094	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293014095	protein binding site [polypeptide binding]; other site
886293014096	Abhydrolase family; Region: Abhydrolase_7; pfam12715
886293014097	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293014098	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293014099	HEAT repeats; Region: HEAT_2; pfam13646
886293014100	HEAT repeats; Region: HEAT_2; pfam13646
886293014101	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
886293014102	HEAT repeats; Region: HEAT_2; pfam13646
886293014103	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293014104	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
886293014105	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
886293014106	Ligand binding site; other site
886293014107	oligomer interface; other site
886293014108	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
886293014109	active site
886293014110	catalytic residues [active]
886293014111	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
886293014112	classical (c) SDRs; Region: SDR_c; cd05233
886293014113	NAD(P) binding site [chemical binding]; other site
886293014114	active site
886293014115	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293014116	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
886293014117	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
886293014118	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293014119	Walker A/P-loop; other site
886293014120	ATP binding site [chemical binding]; other site
886293014121	Q-loop/lid; other site
886293014122	ABC transporter signature motif; other site
886293014123	Walker B; other site
886293014124	D-loop; other site
886293014125	H-loop/switch region; other site
886293014126	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
886293014127	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
886293014128	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
886293014129	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293014130	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293014131	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293014132	AMP-binding domain protein; Validated; Region: PRK08315
886293014133	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
886293014134	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
886293014135	acyl-activating enzyme (AAE) consensus motif; other site
886293014136	putative AMP binding site [chemical binding]; other site
886293014137	putative active site [active]
886293014138	putative CoA binding site [chemical binding]; other site
886293014139	enoyl-CoA hydratase; Provisional; Region: PRK05995
886293014140	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
886293014141	substrate binding site [chemical binding]; other site
886293014142	oxyanion hole (OAH) forming residues; other site
886293014143	trimer interface [polypeptide binding]; other site
886293014144	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
886293014145	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
886293014146	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
886293014147	putative acyltransferase; Provisional; Region: PRK05790
886293014148	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
886293014149	dimer interface [polypeptide binding]; other site
886293014150	active site
886293014151	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
886293014152	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
886293014153	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
886293014154	Phosphoesterase family; Region: Phosphoesterase; pfam04185
886293014155	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293014156	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
886293014157	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
886293014158	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
886293014159	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
886293014160	DDE superfamily endonuclease; Region: DDE_5; cl17874
886293014161	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293014162	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
886293014163	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293014164	Major Facilitator Superfamily; Region: MFS_1; pfam07690
886293014165	putative substrate translocation pore; other site
886293014166	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
886293014167	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
886293014168	active site pocket [active]
886293014169	ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994
886293014170	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
886293014171	active site
886293014172	Zn binding site [ion binding]; other site
886293014173	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293014174	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293014175	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293014176	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293014177	Predicted transcriptional regulators [Transcription]; Region: COG1725
886293014178	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
886293014179	DNA-binding site [nucleotide binding]; DNA binding site
886293014180	FCD domain; Region: FCD; pfam07729
886293014181	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293014182	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
886293014183	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
886293014184	nucleotide binding site [chemical binding]; other site
886293014185	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
886293014186	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898
886293014187	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
886293014188	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293014189	nucleotide binding region [chemical binding]; other site
886293014190	ATP-binding site [chemical binding]; other site
886293014191	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
886293014192	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
886293014193	FAD binding domain; Region: FAD_binding_4; pfam01565
886293014194	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
886293014195	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
886293014196	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
886293014197	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
886293014198	Peptidase family M50; Region: Peptidase_M50; pfam02163
886293014199	active site
886293014200	putative substrate binding region [chemical binding]; other site
886293014201	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293014202	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293014203	active site
886293014204	ATP binding site [chemical binding]; other site
886293014205	substrate binding site [chemical binding]; other site
886293014206	activation loop (A-loop); other site
886293014207	Predicted membrane protein [Function unknown]; Region: COG1971
886293014208	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
886293014209	active site
886293014210	Zn binding site [ion binding]; other site
886293014211	cyanophycin synthetase; Provisional; Region: PRK14016
886293014212	ATP-grasp domain; Region: ATP-grasp_4; cl17255
886293014213	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
886293014214	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
886293014215	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
886293014216	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293014217	putative oxidoreductase; Provisional; Region: PRK11579
886293014218	4-aminobutyrate aminotransferase; Provisional; Region: PRK05769
886293014219	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
886293014220	inhibitor-cofactor binding pocket; inhibition site
886293014221	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293014222	catalytic residue [active]
886293014223	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293014224	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293014225	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293014226	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293014227	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
886293014228	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
886293014229	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293014230	S-adenosylmethionine binding site [chemical binding]; other site
886293014231	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
886293014232	DHH family; Region: DHH; pfam01368
886293014233	DHHA1 domain; Region: DHHA1; pfam02272
886293014234	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
886293014235	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
886293014236	oligomer interface [polypeptide binding]; other site
886293014237	metal binding site [ion binding]; metal-binding site
886293014238	metal binding site [ion binding]; metal-binding site
886293014239	putative Cl binding site [ion binding]; other site
886293014240	aspartate ring; other site
886293014241	basic sphincter; other site
886293014242	hydrophobic gate; other site
886293014243	periplasmic entrance; other site
886293014244	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
886293014245	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
886293014246	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
886293014247	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293014248	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
886293014249	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
886293014250	active site
886293014251	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
886293014252	active site
886293014253	catalytic residues [active]
886293014254	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
886293014255	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
886293014256	active site
886293014257	oxyanion hole [active]
886293014258	PilZ domain; Region: PilZ; pfam07238
886293014259	Dehydratase family; Region: ILVD_EDD; cl00340
886293014260	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
886293014261	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
886293014262	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
886293014263	active site
886293014264	homodimer interface [polypeptide binding]; other site
886293014265	catalytic site [active]
886293014266	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
886293014267	Methyltransferase domain; Region: Methyltransf_23; pfam13489
886293014268	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293014269	S-adenosylmethionine binding site [chemical binding]; other site
886293014270	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293014271	TPR motif; other site
886293014272	TPR repeat; Region: TPR_11; pfam13414
886293014273	binding surface
886293014274	TPR repeat; Region: TPR_11; pfam13414
886293014275	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293014276	binding surface
886293014277	TPR motif; other site
886293014278	TPR repeat; Region: TPR_11; pfam13414
886293014279	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
886293014280	serine O-acetyltransferase; Region: cysE; TIGR01172
886293014281	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
886293014282	trimer interface [polypeptide binding]; other site
886293014283	active site
886293014284	substrate binding site [chemical binding]; other site
886293014285	CoA binding site [chemical binding]; other site
886293014286	Methyltransferase domain; Region: Methyltransf_31; pfam13847
886293014287	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293014288	S-adenosylmethionine binding site [chemical binding]; other site
886293014289	elongation factor P; Validated; Region: PRK00529
886293014290	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
886293014291	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
886293014292	RNA binding site [nucleotide binding]; other site
886293014293	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
886293014294	RNA binding site [nucleotide binding]; other site
886293014295	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
886293014296	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
886293014297	active site
886293014298	Zn binding site [ion binding]; other site
886293014299	D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205
886293014300	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
886293014301	ATP-grasp domain; Region: ATP-grasp_4; cl17255
886293014302	D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205
886293014303	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
886293014304	ATP-grasp domain; Region: ATP-grasp_4; cl17255
886293014305	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
886293014306	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
886293014307	FeS/SAM binding site; other site
886293014308	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
886293014309	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
886293014310	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
886293014311	metal binding site [ion binding]; metal-binding site
886293014312	dimer interface [polypeptide binding]; other site
886293014313	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877
886293014314	Peptidase family M28; Region: Peptidase_M28; pfam04389
886293014315	metal binding site [ion binding]; metal-binding site
886293014316	translocation protein TolB; Provisional; Region: tolB; PRK00178
886293014317	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
886293014318	acyl carrier protein; Provisional; Region: acpP; PRK00982
886293014319	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
886293014320	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
886293014321	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
886293014322	dimer interface [polypeptide binding]; other site
886293014323	active site
886293014324	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
886293014325	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
886293014326	dimer interface [polypeptide binding]; other site
886293014327	active site
886293014328	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
886293014329	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
886293014330	GH3 auxin-responsive promoter; Region: GH3; pfam03321
886293014331	Protein of unknown function (DUF1571); Region: DUF1571; pfam07608
886293014332	Response regulator receiver domain; Region: Response_reg; pfam00072
886293014333	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293014334	active site
886293014335	phosphorylation site [posttranslational modification]
886293014336	intermolecular recognition site; other site
886293014337	dimerization interface [polypeptide binding]; other site
886293014338	High-affinity nickel-transport protein; Region: NicO; cl00964
886293014339	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
886293014340	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
886293014341	active site
886293014342	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
886293014343	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
886293014344	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293014345	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
886293014346	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
886293014347	intersubunit interface [polypeptide binding]; other site
886293014348	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
886293014349	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
886293014350	dimer interface [polypeptide binding]; other site
886293014351	putative PBP binding regions; other site
886293014352	ABC-ATPase subunit  interface; other site
886293014353	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
886293014354	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
886293014355	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
886293014356	metal ion-dependent adhesion site (MIDAS); other site
886293014357	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293014358	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
886293014359	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
886293014360	Walker A motif; other site
886293014361	ATP binding site [chemical binding]; other site
886293014362	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293014363	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
886293014364	Metal-binding active site; metal-binding site
886293014365	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
886293014366	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
886293014367	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
886293014368	putative ribose interaction site [chemical binding]; other site
886293014369	putative ADP binding site [chemical binding]; other site
886293014370	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
886293014371	active site
886293014372	nucleotide binding site [chemical binding]; other site
886293014373	HIGH motif; other site
886293014374	KMSKS motif; other site
886293014375	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
886293014376	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293014377	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
886293014378	metal ion-dependent adhesion site (MIDAS); other site
886293014379	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
886293014380	SEC-C motif; Region: SEC-C; pfam02810
886293014381	TPR repeat; Region: TPR_11; pfam13414
886293014382	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293014383	TPR motif; other site
886293014384	binding surface
886293014385	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293014386	TPR repeat; Region: TPR_11; pfam13414
886293014387	TPR motif; other site
886293014388	binding surface
886293014389	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
886293014390	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
886293014391	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
886293014392	catalytic residue [active]
886293014393	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
886293014394	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
886293014395	ligand binding site [chemical binding]; other site
886293014396	NAD binding site [chemical binding]; other site
886293014397	dimerization interface [polypeptide binding]; other site
886293014398	catalytic site [active]
886293014399	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
886293014400	putative L-serine binding site [chemical binding]; other site
886293014401	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
886293014402	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
886293014403	NAD(P) binding site [chemical binding]; other site
886293014404	catalytic residues [active]
886293014405	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
886293014406	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
886293014407	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293014408	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293014409	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293014410	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293014411	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
886293014412	putative active site [active]
886293014413	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
886293014414	Acyltransferase family; Region: Acyl_transf_3; pfam01757
886293014415	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
886293014416	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
886293014417	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
886293014418	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
886293014419	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
886293014420	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
886293014421	Protein of unknown function (DUF419); Region: DUF419; pfam04237
886293014422	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
886293014423	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
886293014424	FMN binding site [chemical binding]; other site
886293014425	active site
886293014426	catalytic residues [active]
886293014427	substrate binding site [chemical binding]; other site
886293014428	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293014429	S-adenosylmethionine binding site [chemical binding]; other site
886293014430	DEAD-like helicases superfamily; Region: DEXDc; smart00487
886293014431	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
886293014432	ATP binding site [chemical binding]; other site
886293014433	putative Mg++ binding site [ion binding]; other site
886293014434	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293014435	nucleotide binding region [chemical binding]; other site
886293014436	ATP-binding site [chemical binding]; other site
886293014437	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
886293014438	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
886293014439	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
886293014440	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293014441	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293014442	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293014443	Penicillinase repressor; Region: Pencillinase_R; pfam03965
886293014444	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
886293014445	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
886293014446	Proteins of 100 residues with WXG; Region: WXG100; cl02005
886293014447	Family of unknown function (DUF706); Region: DUF706; pfam05153
886293014448	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293014449	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293014450	active site
886293014451	ATP binding site [chemical binding]; other site
886293014452	substrate binding site [chemical binding]; other site
886293014453	activation loop (A-loop); other site
886293014454	Uncharacterized conserved protein [Function unknown]; Region: COG1262
886293014455	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
886293014456	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293014457	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293014458	structural tetrad; other site
886293014459	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293014460	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293014461	structural tetrad; other site
886293014462	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
886293014463	pyruvate dehydrogenase; Provisional; Region: PRK09124
886293014464	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
886293014465	PYR/PP interface [polypeptide binding]; other site
886293014466	dimer interface [polypeptide binding]; other site
886293014467	tetramer interface [polypeptide binding]; other site
886293014468	TPP binding site [chemical binding]; other site
886293014469	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
886293014470	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
886293014471	TPP-binding site [chemical binding]; other site
886293014472	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
886293014473	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
886293014474	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
886293014475	dimerization interface [polypeptide binding]; other site
886293014476	Cupin domain; Region: Cupin_2; pfam07883
886293014477	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
886293014478	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
886293014479	inhibitor site; inhibition site
886293014480	active site
886293014481	dimer interface [polypeptide binding]; other site
886293014482	catalytic residue [active]
886293014483	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
886293014484	Beta-lactamase; Region: Beta-lactamase; pfam00144
886293014485	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
886293014486	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
886293014487	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
886293014488	FMN binding site [chemical binding]; other site
886293014489	active site
886293014490	substrate binding site [chemical binding]; other site
886293014491	catalytic residue [active]
886293014492	DoxX-like family; Region: DoxX_2; pfam13564
886293014493	SnoaL-like domain; Region: SnoaL_2; pfam12680
886293014494	YceI-like domain; Region: YceI; pfam04264
886293014495	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
886293014496	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
886293014497	DNA-binding interface [nucleotide binding]; DNA binding site
886293014498	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
886293014499	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293014500	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
886293014501	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293014502	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
886293014503	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
886293014504	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293014505	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293014506	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293014507	structural tetrad; other site
886293014508	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293014509	PDZ domain; Region: PDZ_2; pfam13180
886293014510	membrane glycoprotein; Provisional; Region: PHA03332
886293014511	Methyltransferase domain; Region: Methyltransf_24; pfam13578
886293014512	putative dehydratase; Provisional; Region: PRK08211
886293014513	Dehydratase family; Region: ILVD_EDD; cl00340
886293014514	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
886293014515	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
886293014516	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
886293014517	putative active site [active]
886293014518	putative NTP binding site [chemical binding]; other site
886293014519	putative nucleic acid binding site [nucleotide binding]; other site
886293014520	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
886293014521	Ferritin-like domain; Region: Ferritin_2; pfam13668
886293014522	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293014523	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293014524	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293014525	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
886293014526	2-enoyl thioester reductase-like; Region: ETR_like; cd05282
886293014527	NADP binding site [chemical binding]; other site
886293014528	dimer interface [polypeptide binding]; other site
886293014529	Uncharacterized conserved protein [Function unknown]; Region: COG0327
886293014530	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
886293014531	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
886293014532	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
886293014533	Uncharacterized conserved protein [Function unknown]; Region: COG0327
886293014534	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
886293014535	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
886293014536	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293014537	catalytic residue [active]
886293014538	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
886293014539	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
886293014540	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
886293014541	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
886293014542	hypothetical protein; Provisional; Region: PRK11239
886293014543	Protein of unknown function, DUF480; Region: DUF480; pfam04337
886293014544	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
886293014545	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
886293014546	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
886293014547	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293014548	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293014549	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293014550	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293014551	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
886293014552	Trehalose utilisation; Region: ThuA; pfam06283
886293014553	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
886293014554	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293014555	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293014556	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293014557	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
886293014558	putative active site [active]
886293014559	dimerization interface [polypeptide binding]; other site
886293014560	putative tRNAtyr binding site [nucleotide binding]; other site
886293014561	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
886293014562	oligomeric interface; other site
886293014563	putative active site [active]
886293014564	homodimer interface [polypeptide binding]; other site
886293014565	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
886293014566	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
886293014567	Substrate binding site; other site
886293014568	Mg++ binding site; other site
886293014569	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
886293014570	putative trimer interface [polypeptide binding]; other site
886293014571	putative CoA binding site [chemical binding]; other site
886293014572	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
886293014573	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
886293014574	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
886293014575	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
886293014576	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
886293014577	GatB domain; Region: GatB_Yqey; pfam02637
886293014578	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
886293014579	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
886293014580	Metal-binding active site; metal-binding site
886293014581	Cupin domain; Region: Cupin_2; pfam07883
886293014582	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
886293014583	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
886293014584	acyl-activating enzyme (AAE) consensus motif; other site
886293014585	AMP binding site [chemical binding]; other site
886293014586	active site
886293014587	CoA binding site [chemical binding]; other site
886293014588	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
886293014589	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
886293014590	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
886293014591	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
886293014592	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293014593	nucleotide binding region [chemical binding]; other site
886293014594	ATP-binding site [chemical binding]; other site
886293014595	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293014596	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293014597	active site
886293014598	ATP binding site [chemical binding]; other site
886293014599	substrate binding site [chemical binding]; other site
886293014600	activation loop (A-loop); other site
886293014601	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
886293014602	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
886293014603	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
886293014604	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
886293014605	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
886293014606	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
886293014607	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
886293014608	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
886293014609	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
886293014610	Ion transport protein; Region: Ion_trans; pfam00520
886293014611	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
886293014612	cyclase homology domain; Region: CHD; cd07302
886293014613	nucleotidyl binding site; other site
886293014614	metal binding site [ion binding]; metal-binding site
886293014615	dimer interface [polypeptide binding]; other site
886293014616	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
886293014617	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293014618	catalytic residues [active]
886293014619	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293014620	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
886293014621	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
886293014622	G1 box; other site
886293014623	GTP/Mg2+ binding site [chemical binding]; other site
886293014624	Switch I region; other site
886293014625	G2 box; other site
886293014626	Switch II region; other site
886293014627	G3 box; other site
886293014628	G4 box; other site
886293014629	G5 box; other site
886293014630	Domain of unknown function (DUF697); Region: DUF697; pfam05128
886293014631	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
886293014632	Amidase; Region: Amidase; cl11426
886293014633	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
886293014634	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
886293014635	G1 box; other site
886293014636	GTP/Mg2+ binding site [chemical binding]; other site
886293014637	Switch I region; other site
886293014638	G2 box; other site
886293014639	Switch II region; other site
886293014640	G3 box; other site
886293014641	G4 box; other site
886293014642	G5 box; other site
886293014643	Domain of unknown function (DUF697); Region: DUF697; pfam05128
886293014644	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
886293014645	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
886293014646	SLBB domain; Region: SLBB; pfam10531
886293014647	PA14 domain; Region: PA14; cl08459
886293014648	Cytochrome c; Region: Cytochrom_C; pfam00034
886293014649	Cytochrome c; Region: Cytochrom_C; pfam00034
886293014650	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293014651	Protein of unknown function (DUF1587); Region: PSD3; pfam07626
886293014652	Protein of unknown function (DUF1595); Region: PSD5; pfam07637
886293014653	Protein of unknown function (DUF1592); Region: PSD4; pfam07631
886293014654	Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627
886293014655	Protein of unknown function (DUF1585); Region: PSD2; pfam07624
886293014656	Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586
886293014657	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
886293014658	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
886293014659	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
886293014660	adenylate kinase; Reviewed; Region: adk; PRK00279
886293014661	AMP-binding site [chemical binding]; other site
886293014662	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
886293014663	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
886293014664	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
886293014665	glutaminase active site [active]
886293014666	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
886293014667	dimer interface [polypeptide binding]; other site
886293014668	active site
886293014669	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
886293014670	dimer interface [polypeptide binding]; other site
886293014671	active site
886293014672	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293014673	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293014674	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
886293014675	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
886293014676	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
886293014677	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
886293014678	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
886293014679	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
886293014680	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
886293014681	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
886293014682	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
886293014683	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
886293014684	Walker A/P-loop; other site
886293014685	ATP binding site [chemical binding]; other site
886293014686	Q-loop/lid; other site
886293014687	ABC transporter signature motif; other site
886293014688	Walker B; other site
886293014689	D-loop; other site
886293014690	H-loop/switch region; other site
886293014691	PAS domain S-box; Region: sensory_box; TIGR00229
886293014692	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293014693	putative active site [active]
886293014694	heme pocket [chemical binding]; other site
886293014695	PAS domain S-box; Region: sensory_box; TIGR00229
886293014696	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293014697	putative active site [active]
886293014698	heme pocket [chemical binding]; other site
886293014699	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293014700	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293014701	dimer interface [polypeptide binding]; other site
886293014702	phosphorylation site [posttranslational modification]
886293014703	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293014704	ATP binding site [chemical binding]; other site
886293014705	Mg2+ binding site [ion binding]; other site
886293014706	G-X-G motif; other site
886293014707	Response regulator receiver domain; Region: Response_reg; pfam00072
886293014708	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293014709	active site
886293014710	phosphorylation site [posttranslational modification]
886293014711	intermolecular recognition site; other site
886293014712	dimerization interface [polypeptide binding]; other site
886293014713	Penicillin amidase; Region: Penicil_amidase; pfam01804
886293014714	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
886293014715	active site
886293014716	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293014717	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293014718	catalytic residues [active]
886293014719	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
886293014720	putative glycosyl transferase; Provisional; Region: PRK10307
886293014721	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293014722	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
886293014723	NAD(P) binding site [chemical binding]; other site
886293014724	active site
886293014725	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293014726	extended (e) SDRs; Region: SDR_e; cd08946
886293014727	NAD(P) binding site [chemical binding]; other site
886293014728	active site
886293014729	substrate binding site [chemical binding]; other site
886293014730	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
886293014731	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
886293014732	PYR/PP interface [polypeptide binding]; other site
886293014733	dimer interface [polypeptide binding]; other site
886293014734	TPP binding site [chemical binding]; other site
886293014735	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
886293014736	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
886293014737	TPP-binding site [chemical binding]; other site
886293014738	Type II/IV secretion system protein; Region: T2SE; pfam00437
886293014739	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
886293014740	Walker A motif; other site
886293014741	ATP binding site [chemical binding]; other site
886293014742	Walker B motif; other site
886293014743	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293014744	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
886293014745	phosphopeptide binding site; other site
886293014746	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293014747	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
886293014748	Metal-binding active site; metal-binding site
886293014749	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
886293014750	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
886293014751	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
886293014752	DNA protecting protein DprA; Region: dprA; TIGR00732
886293014753	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
886293014754	active site
886293014755	dimer interface [polypeptide binding]; other site
886293014756	metal binding site [ion binding]; metal-binding site
886293014757	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
886293014758	Peptidase family M50; Region: Peptidase_M50; pfam02163
886293014759	active site
886293014760	putative substrate binding region [chemical binding]; other site
886293014761	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
886293014762	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
886293014763	Flagellin N-methylase; Region: FliB; pfam03692
886293014764	biotin synthase; Region: bioB; TIGR00433
886293014765	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
886293014766	FeS/SAM binding site; other site
886293014767	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
886293014768	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
886293014769	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
886293014770	dimer interface [polypeptide binding]; other site
886293014771	active site
886293014772	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
886293014773	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
886293014774	substrate-cofactor binding pocket; other site
886293014775	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293014776	catalytic residue [active]
886293014777	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
886293014778	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
886293014779	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
886293014780	catalytic residue [active]
886293014781	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
886293014782	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
886293014783	active site
886293014784	(T/H)XGH motif; other site
886293014785	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
886293014786	HSP70 interaction site [polypeptide binding]; other site
886293014787	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
886293014788	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
886293014789	ADP binding site [chemical binding]; other site
886293014790	phosphagen binding site; other site
886293014791	substrate specificity loop; other site
886293014792	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
886293014793	UvrB/uvrC motif; Region: UVR; pfam02151
886293014794	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
886293014795	UvrB/uvrC motif; Region: UVR; pfam02151
886293014796	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
886293014797	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
886293014798	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
886293014799	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
886293014800	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293014801	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293014802	DNA binding residues [nucleotide binding]
886293014803	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
886293014804	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
886293014805	substrate binding site [chemical binding]; other site
886293014806	ATP binding site [chemical binding]; other site
886293014807	Methyltransferase domain; Region: Methyltransf_23; pfam13489
886293014808	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293014809	S-adenosylmethionine binding site [chemical binding]; other site
886293014810	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
886293014811	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293014812	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293014813	catalytic residues [active]
886293014814	Gram-negative bacterial tonB protein; Region: TonB; cl10048
886293014815	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
886293014816	Protein of unknown function DUF58; Region: DUF58; pfam01882
886293014817	MoxR-like ATPases [General function prediction only]; Region: COG0714
886293014818	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293014819	Walker A motif; other site
886293014820	ATP binding site [chemical binding]; other site
886293014821	Walker B motif; other site
886293014822	arginine finger; other site
886293014823	Integral membrane protein DUF95; Region: DUF95; pfam01944
886293014824	RDD family; Region: RDD; pfam06271
886293014825	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
886293014826	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
886293014827	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
886293014828	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
886293014829	ATP binding site [chemical binding]; other site
886293014830	putative Mg++ binding site [ion binding]; other site
886293014831	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293014832	nucleotide binding region [chemical binding]; other site
886293014833	ATP-binding site [chemical binding]; other site
886293014834	TRCF domain; Region: TRCF; pfam03461
886293014835	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
886293014836	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
886293014837	Interdomain contacts; other site
886293014838	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
886293014839	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
886293014840	active site
886293014841	metal binding site [ion binding]; metal-binding site
886293014842	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
886293014843	putative hydrophobic ligand binding site [chemical binding]; other site
886293014844	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
886293014845	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
886293014846	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
886293014847	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
886293014848	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
886293014849	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
886293014850	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
886293014851	active site
886293014852	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
886293014853	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
886293014854	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
886293014855	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
886293014856	Surface antigen; Region: Bac_surface_Ag; pfam01103
886293014857	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293014858	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
886293014859	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
886293014860	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
886293014861	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
886293014862	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
886293014863	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
886293014864	Walker A motif; other site
886293014865	ATP binding site [chemical binding]; other site
886293014866	Walker B motif; other site
886293014867	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
886293014868	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
886293014869	Walker A motif; other site
886293014870	ATP binding site [chemical binding]; other site
886293014871	Walker B motif; other site
886293014872	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
886293014873	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
886293014874	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
886293014875	Walker A motif; other site
886293014876	ATP binding site [chemical binding]; other site
886293014877	Walker B motif; other site
886293014878	pyruvate phosphate dikinase; Provisional; Region: PRK09279
886293014879	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
886293014880	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
886293014881	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
886293014882	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293014883	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293014884	NAD(P) binding site [chemical binding]; other site
886293014885	active site
886293014886	elongation factor G; Reviewed; Region: PRK00007
886293014887	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
886293014888	G1 box; other site
886293014889	putative GEF interaction site [polypeptide binding]; other site
886293014890	GTP/Mg2+ binding site [chemical binding]; other site
886293014891	Switch I region; other site
886293014892	G2 box; other site
886293014893	G3 box; other site
886293014894	Switch II region; other site
886293014895	G4 box; other site
886293014896	G5 box; other site
886293014897	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
886293014898	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
886293014899	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
886293014900	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
886293014901	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
886293014902	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
886293014903	nucleotide binding site/active site [active]
886293014904	HIT family signature motif; other site
886293014905	catalytic residue [active]
886293014906	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
886293014907	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
886293014908	putative active site [active]
886293014909	aminotransferase; Validated; Region: PRK08175
886293014910	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
886293014911	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293014912	homodimer interface [polypeptide binding]; other site
886293014913	catalytic residue [active]
886293014914	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
886293014915	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293014916	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293014917	protein binding site [polypeptide binding]; other site
886293014918	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293014919	protein binding site [polypeptide binding]; other site
886293014920	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14470
886293014921	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
886293014922	FeS/SAM binding site; other site
886293014923	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293014924	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
886293014925	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
886293014926	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
886293014927	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293014928	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293014929	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
886293014930	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293014931	TPR motif; other site
886293014932	binding surface
886293014933	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
886293014934	Clp amino terminal domain; Region: Clp_N; pfam02861
886293014935	Clp amino terminal domain; Region: Clp_N; pfam02861
886293014936	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293014937	Walker A motif; other site
886293014938	ATP binding site [chemical binding]; other site
886293014939	Walker B motif; other site
886293014940	arginine finger; other site
886293014941	UvrB/uvrC motif; Region: UVR; pfam02151
886293014942	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293014943	Walker A motif; other site
886293014944	ATP binding site [chemical binding]; other site
886293014945	Walker B motif; other site
886293014946	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
886293014947	TPR repeat; Region: TPR_11; pfam13414
886293014948	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293014949	binding surface
886293014950	TPR motif; other site
886293014951	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
886293014952	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
886293014953	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
886293014954	active site
886293014955	Methyltransferase domain; Region: Methyltransf_23; pfam13489
886293014956	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293014957	S-adenosylmethionine binding site [chemical binding]; other site
886293014958	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293014959	Major Facilitator Superfamily; Region: MFS_1; pfam07690
886293014960	putative substrate translocation pore; other site
886293014961	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293014962	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293014963	active site
886293014964	ATP binding site [chemical binding]; other site
886293014965	substrate binding site [chemical binding]; other site
886293014966	activation loop (A-loop); other site
886293014967	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293014968	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293014969	structural tetrad; other site
886293014970	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293014971	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293014972	structural tetrad; other site
886293014973	RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984
886293014974	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293014975	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
886293014976	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293014977	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293014978	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293014979	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
886293014980	Peptidase family M48; Region: Peptidase_M48; cl12018
886293014981	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293014982	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
886293014983	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
886293014984	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
886293014985	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
886293014986	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
886293014987	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
886293014988	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
886293014989	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
886293014990	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
886293014991	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
886293014992	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
886293014993	Walker A motif; other site
886293014994	ATP binding site [chemical binding]; other site
886293014995	Walker B motif; other site
886293014996	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
886293014997	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
886293014998	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
886293014999	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
886293015000	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
886293015001	ATP binding site [chemical binding]; other site
886293015002	putative Mg++ binding site [ion binding]; other site
886293015003	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293015004	nucleotide binding region [chemical binding]; other site
886293015005	ATP-binding site [chemical binding]; other site
886293015006	Helicase associated domain (HA2); Region: HA2; pfam04408
886293015007	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
886293015008	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
886293015009	active site
886293015010	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293015011	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
886293015012	Ligand Binding Site [chemical binding]; other site
886293015013	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
886293015014	Penicillinase repressor; Region: Pencillinase_R; pfam03965
886293015015	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
886293015016	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
886293015017	GTP1/OBG; Region: GTP1_OBG; pfam01018
886293015018	Obg GTPase; Region: Obg; cd01898
886293015019	G1 box; other site
886293015020	GTP/Mg2+ binding site [chemical binding]; other site
886293015021	Switch I region; other site
886293015022	G2 box; other site
886293015023	G3 box; other site
886293015024	Switch II region; other site
886293015025	G4 box; other site
886293015026	G5 box; other site
886293015027	Type III pantothenate kinase; Region: Pan_kinase; cl17198
886293015028	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
886293015029	trmE is a tRNA modification GTPase; Region: trmE; cd04164
886293015030	G1 box; other site
886293015031	GTP/Mg2+ binding site [chemical binding]; other site
886293015032	Switch I region; other site
886293015033	G2 box; other site
886293015034	Switch II region; other site
886293015035	G3 box; other site
886293015036	G4 box; other site
886293015037	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293015038	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293015039	active site
886293015040	ATP binding site [chemical binding]; other site
886293015041	substrate binding site [chemical binding]; other site
886293015042	activation loop (A-loop); other site
886293015043	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293015044	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
886293015045	Zn2+ binding site [ion binding]; other site
886293015046	Mg2+ binding site [ion binding]; other site
886293015047	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
886293015048	protein-splicing catalytic site; other site
886293015049	thioester formation/cholesterol transfer; other site
886293015050	Pretoxin HINT domain; Region: PT-HINT; pfam07591
886293015051	TIGR04222 domain; Region: near_uncomplex
886293015052	L-aspartate oxidase; Provisional; Region: PRK06175
886293015053	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
886293015054	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
886293015055	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
886293015056	Domon-like ligand-binding domains; Region: DOMON_like; cd00241
886293015057	putative ligand binding site [chemical binding]; other site
886293015058	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
886293015059	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
886293015060	dimerization interface [polypeptide binding]; other site
886293015061	putative ATP binding site [chemical binding]; other site
886293015062	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
886293015063	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
886293015064	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
886293015065	TPP-binding site [chemical binding]; other site
886293015066	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
886293015067	dimer interface [polypeptide binding]; other site
886293015068	PYR/PP interface [polypeptide binding]; other site
886293015069	TPP binding site [chemical binding]; other site
886293015070	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
886293015071	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
886293015072	E3 interaction surface; other site
886293015073	lipoyl attachment site [posttranslational modification]; other site
886293015074	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
886293015075	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
886293015076	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
886293015077	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
886293015078	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
886293015079	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
886293015080	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293015081	Penicillinase repressor; Region: Pencillinase_R; cl17580
886293015082	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
886293015083	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293015084	putative substrate translocation pore; other site
886293015085	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293015086	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
886293015087	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
886293015088	TPR repeat; Region: TPR_11; pfam13414
886293015089	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293015090	binding surface
886293015091	TPR repeat; Region: TPR_11; pfam13414
886293015092	TPR motif; other site
886293015093	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
886293015094	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293015095	binding surface
886293015096	TPR motif; other site
886293015097	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
886293015098	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293015099	binding surface
886293015100	TPR motif; other site
886293015101	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293015102	binding surface
886293015103	TPR motif; other site
886293015104	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
886293015105	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
886293015106	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
886293015107	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
886293015108	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
886293015109	E3 interaction surface; other site
886293015110	lipoyl attachment site [posttranslational modification]; other site
886293015111	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
886293015112	pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212
886293015113	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
886293015114	alpha subunit interface [polypeptide binding]; other site
886293015115	TPP binding site [chemical binding]; other site
886293015116	heterodimer interface [polypeptide binding]; other site
886293015117	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
886293015118	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
886293015119	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
886293015120	tetramer interface [polypeptide binding]; other site
886293015121	TPP-binding site [chemical binding]; other site
886293015122	heterodimer interface [polypeptide binding]; other site
886293015123	phosphorylation loop region [posttranslational modification]
886293015124	aconitate hydratase; Validated; Region: PRK09277
886293015125	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
886293015126	substrate binding site [chemical binding]; other site
886293015127	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
886293015128	ligand binding site [chemical binding]; other site
886293015129	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
886293015130	substrate binding site [chemical binding]; other site
886293015131	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107
886293015132	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
886293015133	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
886293015134	Walker A/P-loop; other site
886293015135	ATP binding site [chemical binding]; other site
886293015136	Q-loop/lid; other site
886293015137	ABC transporter signature motif; other site
886293015138	Walker B; other site
886293015139	D-loop; other site
886293015140	H-loop/switch region; other site
886293015141	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
886293015142	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
886293015143	glutamine binding [chemical binding]; other site
886293015144	catalytic triad [active]
886293015145	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
886293015146	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
886293015147	dimer interface [polypeptide binding]; other site
886293015148	putative functional site; other site
886293015149	putative MPT binding site; other site
886293015150	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
886293015151	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
886293015152	putative active site [active]
886293015153	catalytic triad [active]
886293015154	putative dimer interface [polypeptide binding]; other site
886293015155	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
886293015156	Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936
886293015157	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
886293015158	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
886293015159	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
886293015160	putative active site [active]
886293015161	catalytic site [active]
886293015162	ADP-glucose phosphorylase; Region: PLN02643
886293015163	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
886293015164	dimer interface [polypeptide binding]; other site
886293015165	active site
886293015166	N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793
886293015167	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
886293015168	active site
886293015169	catalytic site [active]
886293015170	homodimer interface [polypeptide binding]; other site
886293015171	Lid 1; other site
886293015172	Domain of unknown function (DUF1925); Region: DUF1925; pfam09094
886293015173	Domain of unknown function (DUF1926); Region: DUF1926; pfam09095
886293015174	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
886293015175	Protein of unknown function DUF58; Region: DUF58; pfam01882
886293015176	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
886293015177	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293015178	Coenzyme A binding pocket [chemical binding]; other site
886293015179	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
886293015180	MarR family; Region: MarR_2; pfam12802
886293015181	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293015182	prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294
886293015183	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
886293015184	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293015185	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293015186	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
886293015187	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
886293015188	active site
886293015189	catalytic tetrad [active]
886293015190	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
886293015191	AAA domain; Region: AAA_26; pfam13500
886293015192	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
886293015193	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
886293015194	inhibitor-cofactor binding pocket; inhibition site
886293015195	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293015196	catalytic residue [active]
886293015197	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
886293015198	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
886293015199	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
886293015200	anti sigma factor interaction site; other site
886293015201	regulatory phosphorylation site [posttranslational modification]; other site
886293015202	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
886293015203	MutS domain I; Region: MutS_I; pfam01624
886293015204	MutS domain II; Region: MutS_II; pfam05188
886293015205	MutS domain III; Region: MutS_III; pfam05192
886293015206	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
886293015207	Walker A/P-loop; other site
886293015208	ATP binding site [chemical binding]; other site
886293015209	Q-loop/lid; other site
886293015210	ABC transporter signature motif; other site
886293015211	Walker B; other site
886293015212	D-loop; other site
886293015213	H-loop/switch region; other site
886293015214	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
886293015215	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293015216	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293015217	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293015218	DNA binding residues [nucleotide binding]
886293015219	C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299
886293015220	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
886293015221	ligand binding site [chemical binding]; other site
886293015222	NAD binding site [chemical binding]; other site
886293015223	catalytic site [active]
886293015224	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
886293015225	DDE superfamily endonuclease; Region: DDE_5; cl17874
886293015226	Glucuronate isomerase; Region: UxaC; cl00829
886293015227	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
886293015228	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293015229	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293015230	prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294
886293015231	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
886293015232	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
886293015233	active site
886293015234	substrate-binding site [chemical binding]; other site
886293015235	metal-binding site [ion binding]
886293015236	ATP binding site [chemical binding]; other site
886293015237	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293015238	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293015239	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293015240	DNA binding residues [nucleotide binding]
886293015241	helicase 45; Provisional; Region: PTZ00424
886293015242	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
886293015243	ATP binding site [chemical binding]; other site
886293015244	Mg++ binding site [ion binding]; other site
886293015245	motif III; other site
886293015246	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293015247	nucleotide binding region [chemical binding]; other site
886293015248	ATP-binding site [chemical binding]; other site
886293015249	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293015250	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
886293015251	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293015252	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293015253	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
886293015254	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293015255	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293015256	S-adenosylmethionine binding site [chemical binding]; other site
886293015257	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
886293015258	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
886293015259	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293015260	S-adenosylmethionine binding site [chemical binding]; other site
886293015261	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
886293015262	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
886293015263	putative active site [active]
886293015264	putative metal binding site [ion binding]; other site
886293015265	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293015266	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293015267	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293015268	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
886293015269	Domain of unknown function (DUF362); Region: DUF362; pfam04015
886293015270	Uncharacterized conserved protein [Function unknown]; Region: COG2006
886293015271	Uncharacterized conserved protein [Function unknown]; Region: COG2006
886293015272	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
886293015273	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
886293015274	active site
886293015275	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
886293015276	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
886293015277	inhibitor-cofactor binding pocket; inhibition site
886293015278	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293015279	catalytic residue [active]
886293015280	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
886293015281	Domain of unknown function DUF21; Region: DUF21; pfam01595
886293015282	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
886293015283	Transporter associated domain; Region: CorC_HlyC; smart01091
886293015284	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
886293015285	dimer interface [polypeptide binding]; other site
886293015286	active site
886293015287	Schiff base residues; other site
886293015288	Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607
886293015289	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293015290	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293015291	catalytic residues [active]
886293015292	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
886293015293	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
886293015294	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
886293015295	dimerization interface [polypeptide binding]; other site
886293015296	active site
886293015297	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
886293015298	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
886293015299	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293015300	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293015301	Transcriptional regulator; Region: Rrf2; cl17282
886293015302	Predicted transcriptional regulator [Transcription]; Region: COG1959
886293015303	Anticodon binding domain of tRNAs; Region: HGTP_anticodon2; pfam12745
886293015304	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293015305	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
886293015306	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293015307	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293015308	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293015309	structural tetrad; other site
886293015310	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293015311	structural tetrad; other site
886293015312	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293015313	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
886293015314	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
886293015315	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
886293015316	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
886293015317	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
886293015318	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
886293015319	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
886293015320	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
886293015321	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
886293015322	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
886293015323	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
886293015324	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
886293015325	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
886293015326	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
886293015327	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
886293015328	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293015329	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
886293015330	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
886293015331	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
886293015332	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
886293015333	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
886293015334	Cupin domain; Region: Cupin_2; cl17218
886293015335	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
886293015336	Cytochrome P450; Region: p450; pfam00067
886293015337	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
886293015338	Flavodoxin; Region: Flavodoxin_1; pfam00258
886293015339	These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206
886293015340	FAD binding pocket [chemical binding]; other site
886293015341	FAD binding motif [chemical binding]; other site
886293015342	catalytic residues [active]
886293015343	NAD binding pocket [chemical binding]; other site
886293015344	phosphate binding motif [ion binding]; other site
886293015345	beta-alpha-beta structure motif; other site
886293015346	Predicted GTPase [General function prediction only]; Region: DRG; COG1163
886293015347	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
886293015348	G1 box; other site
886293015349	GTP/Mg2+ binding site [chemical binding]; other site
886293015350	G2 box; other site
886293015351	Switch I region; other site
886293015352	G3 box; other site
886293015353	Switch II region; other site
886293015354	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
886293015355	G4 box; other site
886293015356	G5 box; other site
886293015357	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
886293015358	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293015359	Response regulator receiver domain; Region: Response_reg; pfam00072
886293015360	active site
886293015361	phosphorylation site [posttranslational modification]
886293015362	intermolecular recognition site; other site
886293015363	dimerization interface [polypeptide binding]; other site
886293015364	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
886293015365	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293015366	ATP binding site [chemical binding]; other site
886293015367	Mg2+ binding site [ion binding]; other site
886293015368	G-X-G motif; other site
886293015369	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293015370	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293015371	active site
886293015372	phosphorylation site [posttranslational modification]
886293015373	intermolecular recognition site; other site
886293015374	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293015375	dimerization interface [polypeptide binding]; other site
886293015376	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293015377	dimer interface [polypeptide binding]; other site
886293015378	phosphorylation site [posttranslational modification]
886293015379	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293015380	ATP binding site [chemical binding]; other site
886293015381	Mg2+ binding site [ion binding]; other site
886293015382	G-X-G motif; other site
886293015383	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
886293015384	active site
886293015385	catalytic residues [active]
886293015386	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
886293015387	D-ribose pyranase; Provisional; Region: PRK11797
886293015388	TIGR03790 family protein; Region: TIGR03790
886293015389	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
886293015390	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
886293015391	conserved cys residue [active]
886293015392	Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795
886293015393	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
886293015394	Mechanosensitive ion channel; Region: MS_channel; pfam00924
886293015395	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
886293015396	protein-splicing catalytic site; other site
886293015397	thioester formation/cholesterol transfer; other site
886293015398	CopC domain; Region: CopC; cl01012
886293015399	Protein kinase domain; Region: Pkinase; pfam00069
886293015400	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293015401	active site
886293015402	ATP binding site [chemical binding]; other site
886293015403	substrate binding site [chemical binding]; other site
886293015404	activation loop (A-loop); other site
886293015405	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
886293015406	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293015407	TPR motif; other site
886293015408	binding surface
886293015409	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293015410	binding surface
886293015411	TPR motif; other site
886293015412	TPR repeat; Region: TPR_11; pfam13414
886293015413	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293015414	binding surface
886293015415	TPR motif; other site
886293015416	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293015417	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
886293015418	phosphopeptide binding site; other site
886293015419	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
886293015420	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
886293015421	metal binding site [ion binding]; metal-binding site
886293015422	active site
886293015423	I-site; other site
886293015424	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
886293015425	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
886293015426	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
886293015427	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
886293015428	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
886293015429	L-aspartate oxidase; Provisional; Region: PRK06175
886293015430	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
886293015431	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
886293015432	putative Iron-sulfur protein interface [polypeptide binding]; other site
886293015433	putative proximal heme binding site [chemical binding]; other site
886293015434	putative SdhC-like subunit interface [polypeptide binding]; other site
886293015435	putative distal heme binding site [chemical binding]; other site
886293015436	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
886293015437	putative Iron-sulfur protein interface [polypeptide binding]; other site
886293015438	putative proximal heme binding site [chemical binding]; other site
886293015439	putative SdhD-like interface [polypeptide binding]; other site
886293015440	putative distal heme binding site [chemical binding]; other site
886293015441	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
886293015442	putative deacylase active site [active]
886293015443	Proline dehydrogenase; Region: Pro_dh; cl03282
886293015444	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
886293015445	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
886293015446	Glutamate binding site [chemical binding]; other site
886293015447	homodimer interface [polypeptide binding]; other site
886293015448	NAD binding site [chemical binding]; other site
886293015449	catalytic residues [active]
886293015450	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
886293015451	SnoaL-like domain; Region: SnoaL_3; pfam13474
886293015452	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293015453	binding surface
886293015454	Tetratricopeptide repeat; Region: TPR_16; pfam13432
886293015455	TPR motif; other site
886293015456	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293015457	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293015458	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
886293015459	AP (apurinic/apyrimidinic) site pocket; other site
886293015460	DNA interaction; other site
886293015461	Metal-binding active site; metal-binding site
886293015462	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293015463	threonine synthase; Validated; Region: PRK07591
886293015464	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
886293015465	homodimer interface [polypeptide binding]; other site
886293015466	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293015467	catalytic residue [active]
886293015468	Ubiquitin-like proteins; Region: UBQ; cl00155
886293015469	charged pocket; other site
886293015470	hydrophobic patch; other site
886293015471	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
886293015472	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
886293015473	ATP binding site [chemical binding]; other site
886293015474	substrate interface [chemical binding]; other site
886293015475	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
886293015476	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
886293015477	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
886293015478	catalytic residue [active]
886293015479	Tetratricopeptide repeat; Region: TPR_15; pfam13429
886293015480	Tetratricopeptide repeat; Region: TPR_1; pfam00515
886293015481	binding surface
886293015482	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
886293015483	NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180
886293015484	NAD binding site [chemical binding]; other site
886293015485	substrate binding site [chemical binding]; other site
886293015486	active site
886293015487	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
886293015488	DHH family; Region: DHH; pfam01368
886293015489	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
886293015490	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
886293015491	iron-sulfur cluster [ion binding]; other site
886293015492	[2Fe-2S] cluster binding site [ion binding]; other site
886293015493	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
886293015494	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
886293015495	heme bH binding site [chemical binding]; other site
886293015496	intrachain domain interface; other site
886293015497	Qi binding site; other site
886293015498	heme bL binding site [chemical binding]; other site
886293015499	interchain domain interface [polypeptide binding]; other site
886293015500	Qo binding site; other site
886293015501	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
886293015502	Cytochrome c; Region: Cytochrom_C; pfam00034
886293015503	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
886293015504	Peptidase C26; Region: Peptidase_C26; pfam07722
886293015505	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
886293015506	catalytic triad [active]
886293015507	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
886293015508	ThiC family; Region: ThiC; pfam01964
886293015509	Protein of unknown function (DUF1571); Region: DUF1571; pfam07608
886293015510	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
886293015511	tartrate dehydrogenase; Region: TTC; TIGR02089
886293015512	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
886293015513	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293015514	active site
886293015515	ATP binding site [chemical binding]; other site
886293015516	substrate binding site [chemical binding]; other site
886293015517	activation loop (A-loop); other site
886293015518	AAA ATPase domain; Region: AAA_16; pfam13191
886293015519	Predicted ATPase [General function prediction only]; Region: COG3899
886293015520	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
886293015521	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
886293015522	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
886293015523	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
886293015524	metal binding site [ion binding]; metal-binding site
886293015525	active site
886293015526	I-site; other site
886293015527	Peptidase family M1; Region: Peptidase_M1; pfam01433
886293015528	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
886293015529	Zn binding site [ion binding]; other site
886293015530	HEAT repeats; Region: HEAT_2; pfam13646
886293015531	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
886293015532	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
886293015533	RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984
886293015534	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293015535	DNA binding residues [nucleotide binding]
886293015536	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293015537	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293015538	active site
886293015539	ATP binding site [chemical binding]; other site
886293015540	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293015541	substrate binding site [chemical binding]; other site
886293015542	activation loop (A-loop); other site
886293015543	Uncharacterized conserved protein [Function unknown]; Region: COG3391
886293015544	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293015545	structural tetrad; other site
886293015546	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293015547	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293015548	structural tetrad; other site
886293015549	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293015550	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293015551	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293015552	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
886293015553	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
886293015554	putative active site [active]
886293015555	putative NTP binding site [chemical binding]; other site
886293015556	putative nucleic acid binding site [nucleotide binding]; other site
886293015557	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
886293015558	Histidine kinase; Region: His_kinase; pfam06580
886293015559	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293015560	Mg2+ binding site [ion binding]; other site
886293015561	G-X-G motif; other site
886293015562	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
886293015563	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293015564	active site
886293015565	phosphorylation site [posttranslational modification]
886293015566	intermolecular recognition site; other site
886293015567	dimerization interface [polypeptide binding]; other site
886293015568	LytTr DNA-binding domain; Region: LytTR; pfam04397
886293015569	Domain of unknown function (DUF4394); Region: DUF4394; pfam14339
886293015570	Domain of unknown function (DUF4394); Region: DUF4394; pfam14339
886293015571	Methane oxygenase PmoA; Region: PmoA; pfam14100
886293015572	FliW protein; Region: FliW; cl00740
886293015573	Global regulator protein family; Region: CsrA; cl00670
886293015574	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
886293015575	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
886293015576	Walker A/P-loop; other site
886293015577	ATP binding site [chemical binding]; other site
886293015578	Q-loop/lid; other site
886293015579	ABC transporter signature motif; other site
886293015580	Walker B; other site
886293015581	D-loop; other site
886293015582	H-loop/switch region; other site
886293015583	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
886293015584	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
886293015585	dimer interface [polypeptide binding]; other site
886293015586	conserved gate region; other site
886293015587	putative PBP binding loops; other site
886293015588	ABC-ATPase subunit interface; other site
886293015589	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
886293015590	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
886293015591	substrate binding pocket [chemical binding]; other site
886293015592	membrane-bound complex binding site; other site
886293015593	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
886293015594	active site
886293015595	iron coordination sites [ion binding]; other site
886293015596	substrate binding pocket [chemical binding]; other site
886293015597	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
886293015598	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
886293015599	phosphopeptide binding site; other site
886293015600	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
886293015601	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293015602	Methyltransferase domain; Region: Methyltransf_23; pfam13489
886293015603	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293015604	S-adenosylmethionine binding site [chemical binding]; other site
886293015605	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
886293015606	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
886293015607	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
886293015608	purine monophosphate binding site [chemical binding]; other site
886293015609	dimer interface [polypeptide binding]; other site
886293015610	putative catalytic residues [active]
886293015611	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
886293015612	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
886293015613	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
886293015614	Trp docking motif [polypeptide binding]; other site
886293015615	PQQ-like domain; Region: PQQ_2; pfam13360
886293015616	active site
886293015617	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
886293015618	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293015619	Coenzyme A binding pocket [chemical binding]; other site
886293015620	Protein of unknown function (DUF1571); Region: DUF1571; pfam07608
886293015621	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
886293015622	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
886293015623	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
886293015624	active site
886293015625	metal binding site [ion binding]; metal-binding site
886293015626	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
886293015627	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
886293015628	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
886293015629	shikimate binding site; other site
886293015630	NAD(P) binding site [chemical binding]; other site
886293015631	Global regulator protein family; Region: CsrA; pfam02599
886293015632	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
886293015633	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
886293015634	Metal-binding active site; metal-binding site
886293015635	oligosaccharide amylase; Region: oligosac_amyl; TIGR01577
886293015636	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
886293015637	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
886293015638	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
886293015639	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
886293015640	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
886293015641	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293015642	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293015643	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293015644	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293015645	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293015646	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
886293015647	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
886293015648	nucleotide binding site [chemical binding]; other site
886293015649	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
886293015650	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
886293015651	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
886293015652	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293015653	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293015654	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293015655	prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294
886293015656	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
886293015657	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293015658	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293015659	catalytic residues [active]
886293015660	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293015661	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293015662	active site
886293015663	ATP binding site [chemical binding]; other site
886293015664	substrate binding site [chemical binding]; other site
886293015665	activation loop (A-loop); other site
886293015666	RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984
886293015667	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293015668	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293015669	DNA binding residues [nucleotide binding]
886293015670	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
886293015671	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293015672	active site
886293015673	phosphorylation site [posttranslational modification]
886293015674	intermolecular recognition site; other site
886293015675	dimerization interface [polypeptide binding]; other site
886293015676	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293015677	Walker A motif; other site
886293015678	ATP binding site [chemical binding]; other site
886293015679	Walker B motif; other site
886293015680	arginine finger; other site
886293015681	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
886293015682	dimerization interface [polypeptide binding]; other site
886293015683	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
886293015684	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293015685	dimer interface [polypeptide binding]; other site
886293015686	phosphorylation site [posttranslational modification]
886293015687	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293015688	ATP binding site [chemical binding]; other site
886293015689	Mg2+ binding site [ion binding]; other site
886293015690	G-X-G motif; other site
886293015691	magnesium-transporting ATPase; Provisional; Region: PRK15122
886293015692	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
886293015693	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
886293015694	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
886293015695	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
886293015696	Soluble P-type ATPase [General function prediction only]; Region: COG4087
886293015697	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
886293015698	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
886293015699	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293015700	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
886293015701	Outer membrane efflux protein; Region: OEP; pfam02321
886293015702	Outer membrane efflux protein; Region: OEP; pfam02321
886293015703	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
886293015704	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293015705	active site
886293015706	phosphorylation site [posttranslational modification]
886293015707	intermolecular recognition site; other site
886293015708	dimerization interface [polypeptide binding]; other site
886293015709	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
886293015710	DNA binding site [nucleotide binding]
886293015711	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
886293015712	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
886293015713	dimerization interface [polypeptide binding]; other site
886293015714	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293015715	dimer interface [polypeptide binding]; other site
886293015716	phosphorylation site [posttranslational modification]
886293015717	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293015718	ATP binding site [chemical binding]; other site
886293015719	Mg2+ binding site [ion binding]; other site
886293015720	G-X-G motif; other site
886293015721	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293015722	prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294
886293015723	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
886293015724	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
886293015725	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293015726	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293015727	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
886293015728	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293015729	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
886293015730	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
886293015731	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
886293015732	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810
886293015733	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
886293015734	catalytic site [active]
886293015735	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
886293015736	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
886293015737	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
886293015738	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
886293015739	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
886293015740	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
886293015741	active site
886293015742	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
886293015743	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
886293015744	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
886293015745	putative RNA binding site [nucleotide binding]; other site
886293015746	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
886293015747	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
886293015748	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
886293015749	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
886293015750	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
886293015751	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
886293015752	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
886293015753	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
886293015754	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
886293015755	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293015756	active site
886293015757	phosphorylation site [posttranslational modification]
886293015758	intermolecular recognition site; other site
886293015759	dimerization interface [polypeptide binding]; other site
886293015760	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293015761	Walker A motif; other site
886293015762	ATP binding site [chemical binding]; other site
886293015763	Walker B motif; other site
886293015764	arginine finger; other site
886293015765	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
886293015766	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293015767	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293015768	protein binding site [polypeptide binding]; other site
886293015769	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293015770	protein binding site [polypeptide binding]; other site
886293015771	DDE superfamily endonuclease; Region: DDE_5; cl17874
886293015772	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293015773	HEAT repeats; Region: HEAT_2; pfam13646
886293015774	HEAT repeats; Region: HEAT_2; pfam13646
886293015775	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
886293015776	excinuclease ABC subunit B; Provisional; Region: PRK05298
886293015777	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
886293015778	ATP binding site [chemical binding]; other site
886293015779	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293015780	nucleotide binding region [chemical binding]; other site
886293015781	ATP-binding site [chemical binding]; other site
886293015782	Ultra-violet resistance protein B; Region: UvrB; pfam12344
886293015783	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
886293015784	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
886293015785	dimerization interface [polypeptide binding]; other site
886293015786	active site
886293015787	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
886293015788	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
886293015789	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293015790	binding surface
886293015791	TPR motif; other site
886293015792	TPR repeat; Region: TPR_11; pfam13414
886293015793	DoxX; Region: DoxX; cl17842
886293015794	Pirin-related protein [General function prediction only]; Region: COG1741
886293015795	Pirin; Region: Pirin; pfam02678
886293015796	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
886293015797	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
886293015798	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
886293015799	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
886293015800	PA/protease or protease-like domain interface [polypeptide binding]; other site
886293015801	M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663
886293015802	Peptidase family M28; Region: Peptidase_M28; pfam04389
886293015803	metal binding site [ion binding]; metal-binding site
886293015804	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293015805	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
886293015806	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
886293015807	Walker A/P-loop; other site
886293015808	ATP binding site [chemical binding]; other site
886293015809	Q-loop/lid; other site
886293015810	ABC transporter signature motif; other site
886293015811	Walker B; other site
886293015812	D-loop; other site
886293015813	H-loop/switch region; other site
886293015814	TOBE domain; Region: TOBE_2; pfam08402
886293015815	DDE superfamily endonuclease; Region: DDE_5; cl17874
886293015816	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
886293015817	dimer interface [polypeptide binding]; other site
886293015818	conserved gate region; other site
886293015819	putative PBP binding loops; other site
886293015820	ABC-ATPase subunit interface; other site
886293015821	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
886293015822	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
886293015823	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
886293015824	catalytic site [active]
886293015825	subunit interface [polypeptide binding]; other site
886293015826	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
886293015827	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
886293015828	GDP-binding site [chemical binding]; other site
886293015829	ACT binding site; other site
886293015830	IMP binding site; other site
886293015831	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
886293015832	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
886293015833	catalytic residue [active]
886293015834	putative FPP diphosphate  binding site; other site
886293015835	putative FPP binding hydrophobic cleft; other site
886293015836	dimer interface [polypeptide binding]; other site
886293015837	putative IPP diphosphate binding site; other site
886293015838	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
886293015839	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
886293015840	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
886293015841	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293015842	non-specific DNA binding site [nucleotide binding]; other site
886293015843	salt bridge; other site
886293015844	sequence-specific DNA binding site [nucleotide binding]; other site
886293015845	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
886293015846	PhoH-like protein; Region: PhoH; pfam02562
886293015847	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
886293015848	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
886293015849	Zn2+ binding site [ion binding]; other site
886293015850	Mg2+ binding site [ion binding]; other site
886293015851	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
886293015852	FOG: CBS domain [General function prediction only]; Region: COG0517
886293015853	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
886293015854	Transporter associated domain; Region: CorC_HlyC; smart01091
886293015855	Recombination protein O N terminal; Region: RecO_N; pfam11967
886293015856	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
886293015857	Recombination protein O C terminal; Region: RecO_C; pfam02565
886293015858	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
886293015859	von Willebrand factor; Region: vWF_A; pfam12450
886293015860	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
886293015861	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
886293015862	metal ion-dependent adhesion site (MIDAS); other site
886293015863	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
886293015864	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
886293015865	putative catalytic cysteine [active]
886293015866	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
886293015867	dihydropteroate synthase; Region: DHPS; TIGR01496
886293015868	substrate binding pocket [chemical binding]; other site
886293015869	dimer interface [polypeptide binding]; other site
886293015870	inhibitor binding site; inhibition site
886293015871	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
886293015872	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
886293015873	active site residue [active]
886293015874	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
886293015875	active site residue [active]
886293015876	glutamate dehydrogenase; Provisional; Region: PRK09414
886293015877	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
886293015878	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
886293015879	NAD(P) binding site [chemical binding]; other site
886293015880	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
886293015881	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293015882	Sulfatase; Region: Sulfatase; pfam00884
886293015883	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293015884	Sulfatase; Region: Sulfatase; cl17466
886293015885	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353
886293015886	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
886293015887	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
886293015888	putative active site [active]
886293015889	putative NTP binding site [chemical binding]; other site
886293015890	putative nucleic acid binding site [nucleotide binding]; other site
886293015891	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
886293015892	OsmC-like protein; Region: OsmC; pfam02566
886293015893	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
886293015894	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
886293015895	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
886293015896	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
886293015897	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
886293015898	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
886293015899	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
886293015900	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
886293015901	Part of AAA domain; Region: AAA_19; pfam13245
886293015902	Family description; Region: UvrD_C_2; pfam13538
886293015903	transcription termination factor Rho; Provisional; Region: PRK12608
886293015904	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
886293015905	RNA binding site [nucleotide binding]; other site
886293015906	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
886293015907	Walker A motif; other site
886293015908	ATP binding site [chemical binding]; other site
886293015909	Walker B motif; other site
886293015910	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293015911	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293015912	Protein of unknown function (DUF819); Region: DUF819; cl02317
886293015913	Uncharacterized conserved protein [Function unknown]; Region: COG1262
886293015914	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
886293015915	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
886293015916	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
886293015917	active site
886293015918	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293015919	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293015920	NAD(P) binding site [chemical binding]; other site
886293015921	active site
886293015922	von Willebrand factor; Region: vWF_A; pfam12450
886293015923	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
886293015924	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
886293015925	metal ion-dependent adhesion site (MIDAS); other site
886293015926	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
886293015927	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293015928	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293015929	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293015930	DNA binding residues [nucleotide binding]
886293015931	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293015932	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293015933	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293015934	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
886293015935	Peptidase family M50; Region: Peptidase_M50; pfam02163
886293015936	active site
886293015937	putative substrate binding region [chemical binding]; other site
886293015938	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
886293015939	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293015940	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
886293015941	PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...; Region: PA_GCPII_like; cd02121
886293015942	apical/protease domain interface [polypeptide binding]; other site
886293015943	substrate binding [chemical binding]; other site
886293015944	dimer interface [polypeptide binding]; other site
886293015945	M28 Zn-peptidase prostate-specific membrane antigen; Region: M28_PSMA_like; cd08022
886293015946	dimer interface [polypeptide binding]; other site
886293015947	Peptidase family M28; Region: Peptidase_M28; pfam04389
886293015948	active site
886293015949	metal binding site [ion binding]; metal-binding site
886293015950	Transferrin receptor-like dimerisation domain; Region: TFR_dimer; pfam04253
886293015951	amino acid transporter; Region: 2A0306; TIGR00909
886293015952	Haem-binding domain; Region: Haem_bd; pfam14376
886293015953	Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712
886293015954	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
886293015955	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
886293015956	NADP binding site [chemical binding]; other site
886293015957	active site
886293015958	putative substrate binding site [chemical binding]; other site
886293015959	ParB-like nuclease domain; Region: ParB; smart00470
886293015960	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
886293015961	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
886293015962	FeS/SAM binding site; other site
886293015963	HemN C-terminal domain; Region: HemN_C; pfam06969
886293015964	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
886293015965	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
886293015966	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
886293015967	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293015968	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293015969	Methane oxygenase PmoA; Region: PmoA; pfam14100
886293015970	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
886293015971	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
886293015972	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
886293015973	ATP synthase A chain; Region: ATP-synt_A; cl00413
886293015974	ATP synthase subunit C; Region: ATP-synt_C; cl00466
886293015975	F0F1 ATP synthase subunit B; Provisional; Region: PRK13461
886293015976	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
886293015977	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
886293015978	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
886293015979	F0F1-type ATP synthase, alpha subunit [Energy production and conversion]; Region: AtpA; COG0056
886293015980	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
886293015981	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
886293015982	beta subunit interaction interface [polypeptide binding]; other site
886293015983	Walker A motif; other site
886293015984	ATP binding site [chemical binding]; other site
886293015985	Walker B motif; other site
886293015986	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
886293015987	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
886293015988	core domain interface [polypeptide binding]; other site
886293015989	delta subunit interface [polypeptide binding]; other site
886293015990	epsilon subunit interface [polypeptide binding]; other site
886293015991	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
886293015992	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
886293015993	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
886293015994	alpha subunit interaction interface [polypeptide binding]; other site
886293015995	Walker A motif; other site
886293015996	ATP binding site [chemical binding]; other site
886293015997	Walker B motif; other site
886293015998	inhibitor binding site; inhibition site
886293015999	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
886293016000	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
886293016001	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
886293016002	gamma subunit interface [polypeptide binding]; other site
886293016003	epsilon subunit interface [polypeptide binding]; other site
886293016004	LBP interface [polypeptide binding]; other site
886293016005	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
886293016006	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
886293016007	active site
886293016008	metal binding site [ion binding]; metal-binding site
886293016009	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
886293016010	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
886293016011	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
886293016012	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
886293016013	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
886293016014	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
886293016015	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
886293016016	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
886293016017	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
886293016018	UbiA prenyltransferase family; Region: UbiA; pfam01040
886293016019	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
886293016020	Subunit I/III interface [polypeptide binding]; other site
886293016021	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
886293016022	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626
886293016023	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
886293016024	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
886293016025	Cu(I) binding site [ion binding]; other site
886293016026	Protein of unknown function (DUF420); Region: DUF420; pfam04238
886293016027	putative mechanosensitive channel protein; Provisional; Region: PRK11465
886293016028	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
886293016029	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293016030	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
886293016031	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293016032	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293016033	dimerization interface [polypeptide binding]; other site
886293016034	putative Zn2+ binding site [ion binding]; other site
886293016035	putative DNA binding site [nucleotide binding]; other site
886293016036	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
886293016037	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
886293016038	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
886293016039	NAD-dependent deacetylase; Provisional; Region: PRK00481
886293016040	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
886293016041	NAD+ binding site [chemical binding]; other site
886293016042	substrate binding site [chemical binding]; other site
886293016043	Zn binding site [ion binding]; other site
886293016044	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293016045	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
886293016046	DNA interaction; other site
886293016047	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
886293016048	active site
886293016049	dimer interface [polypeptide binding]; other site
886293016050	Uncharacterized conserved protein [Function unknown]; Region: COG5649
886293016051	Uncharacterized conserved protein [Function unknown]; Region: COG5649
886293016052	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
886293016053	putative hydrophobic ligand binding site [chemical binding]; other site
886293016054	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293016055	dimerization interface [polypeptide binding]; other site
886293016056	putative DNA binding site [nucleotide binding]; other site
886293016057	putative Zn2+ binding site [ion binding]; other site
886293016058	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293016059	Coenzyme A binding pocket [chemical binding]; other site
886293016060	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293016061	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
886293016062	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293016063	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
886293016064	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
886293016065	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
886293016066	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
886293016067	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
886293016068	dimer interface [polypeptide binding]; other site
886293016069	putative functional site; other site
886293016070	putative MPT binding site; other site
886293016071	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
886293016072	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cl00559
886293016073	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293016074	active site
886293016075	Amidohydrolase; Region: Amidohydro_2; pfam04909
886293016076	Amidohydrolase; Region: Amidohydro_2; pfam04909
886293016077	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
886293016078	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
886293016079	inhibitor-cofactor binding pocket; inhibition site
886293016080	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293016081	catalytic residue [active]
886293016082	TadE-like protein; Region: TadE; pfam07811
886293016083	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
886293016084	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293016085	active site
886293016086	phosphorylation site [posttranslational modification]
886293016087	intermolecular recognition site; other site
886293016088	dimerization interface [polypeptide binding]; other site
886293016089	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
886293016090	DNA binding residues [nucleotide binding]
886293016091	dimerization interface [polypeptide binding]; other site
886293016092	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
886293016093	Amidase; Region: Amidase; cl11426
886293016094	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293016095	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
886293016096	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293016097	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
886293016098	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
886293016099	dimer interface [polypeptide binding]; other site
886293016100	acyl-activating enzyme (AAE) consensus motif; other site
886293016101	putative active site [active]
886293016102	AMP binding site [chemical binding]; other site
886293016103	putative CoA binding site [chemical binding]; other site
886293016104	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293016105	putative DNA binding site [nucleotide binding]; other site
886293016106	dimerization interface [polypeptide binding]; other site
886293016107	putative Zn2+ binding site [ion binding]; other site
886293016108	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293016109	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293016110	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293016111	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
886293016112	metal-binding site [ion binding]
886293016113	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
886293016114	active site
886293016115	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293016116	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844
886293016117	active site
886293016118	catalytic triad [active]
886293016119	oxyanion hole [active]
886293016120	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293016121	Sulfatase; Region: Sulfatase; cl17466
886293016122	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293016123	Sulfatase; Region: Sulfatase; cl17466
886293016124	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
886293016125	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
886293016126	putative metal binding site [ion binding]; other site
886293016127	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
886293016128	anti sigma factor interaction site; other site
886293016129	regulatory phosphorylation site [posttranslational modification]; other site
886293016130	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293016131	Sulfatase; Region: Sulfatase; cl17466
886293016132	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293016133	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293016134	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293016135	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
886293016136	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
886293016137	Right handed beta helix region; Region: Beta_helix; pfam13229
886293016138	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293016139	HEAT repeats; Region: HEAT_2; pfam13646
886293016140	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293016141	Cytochrome c; Region: Cytochrom_C; pfam00034
886293016142	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
886293016143	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293016144	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293016145	Cytochrome c; Region: Cytochrom_C; pfam00034
886293016146	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293016147	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293016148	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293016149	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293016150	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293016151	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293016152	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293016153	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293016154	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293016155	D-galactonate transporter; Region: 2A0114; TIGR00893
886293016156	putative substrate translocation pore; other site
886293016157	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293016158	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293016159	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293016160	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293016161	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293016162	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293016163	Abhydrolase family; Region: Abhydrolase_7; pfam12715
886293016164	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293016165	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
886293016166	Peptidase family M23; Region: Peptidase_M23; pfam01551
886293016167	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
886293016168	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
886293016169	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
886293016170	active site
886293016171	NodB motif; other site
886293016172	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293016173	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293016174	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293016175	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
886293016176	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293016177	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
886293016178	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293016179	non-specific DNA binding site [nucleotide binding]; other site
886293016180	salt bridge; other site
886293016181	sequence-specific DNA binding site [nucleotide binding]; other site
886293016182	Cupin domain; Region: Cupin_2; cl17218
886293016183	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
886293016184	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293016185	Coenzyme A binding pocket [chemical binding]; other site
886293016186	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
886293016187	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293016188	tRNA-specific 2-thiouridylase MnmA; Reviewed; Region: mnmA; PRK00143
886293016189	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
886293016190	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293016191	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
886293016192	Mechanosensitive ion channel; Region: MS_channel; pfam00924
886293016193	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293016194	S-adenosylmethionine binding site [chemical binding]; other site
886293016195	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
886293016196	ABC transporter ATPase component; Reviewed; Region: PRK11147
886293016197	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
886293016198	ABC transporter; Region: ABC_tran_2; pfam12848
886293016199	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
886293016200	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293016201	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293016202	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293016203	DNA binding residues [nucleotide binding]
886293016204	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
886293016205	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293016206	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293016207	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
886293016208	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
886293016209	Walker A/P-loop; other site
886293016210	ATP binding site [chemical binding]; other site
886293016211	Q-loop/lid; other site
886293016212	ABC transporter signature motif; other site
886293016213	Walker B; other site
886293016214	D-loop; other site
886293016215	H-loop/switch region; other site
886293016216	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
886293016217	Domain of unknown function (DUF3526); Region: DUF3526; pfam12040
886293016218	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
886293016219	Domain of unknown function (DUF3526); Region: DUF3526; pfam12040
886293016220	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
886293016221	TPR motif; other site
886293016222	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293016223	binding surface
886293016224	TPR motif; other site
886293016225	TPR repeat; Region: TPR_11; pfam13414
886293016226	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
886293016227	TPR motif; other site
886293016228	binding surface
886293016229	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
886293016230	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293016231	prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294
886293016232	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293016233	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293016234	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
886293016235	intersubunit interface [polypeptide binding]; other site
886293016236	active site
886293016237	Zn2+ binding site [ion binding]; other site
886293016238	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
886293016239	intersubunit interface [polypeptide binding]; other site
886293016240	active site
886293016241	Zn2+ binding site [ion binding]; other site
886293016242	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
886293016243	Domain of unknown function DUF87; Region: DUF87; pfam01935
886293016244	AAA-like domain; Region: AAA_10; pfam12846
886293016245	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
886293016246	putative active site [active]
886293016247	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
886293016248	L-rhamnose isomerase; Provisional; Region: PRK01076
886293016249	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
886293016250	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
886293016251	Walker A/P-loop; other site
886293016252	ATP binding site [chemical binding]; other site
886293016253	Q-loop/lid; other site
886293016254	ABC transporter signature motif; other site
886293016255	Walker B; other site
886293016256	D-loop; other site
886293016257	H-loop/switch region; other site
886293016258	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
886293016259	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
886293016260	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
886293016261	TM-ABC transporter signature motif; other site
886293016262	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
886293016263	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
886293016264	TM-ABC transporter signature motif; other site
886293016265	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
886293016266	rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637
886293016267	ligand binding site [chemical binding]; other site
886293016268	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293016269	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
886293016270	NAD(P) binding site [chemical binding]; other site
886293016271	active site
886293016272	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
886293016273	conserved cys residue [active]
886293016274	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
886293016275	Domain of unknown function (DUF303); Region: DUF303; pfam03629
886293016276	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
886293016277	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293016278	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
886293016279	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293016280	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293016281	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293016282	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
886293016283	Uncharacterized conserved protein [Function unknown]; Region: COG1359
886293016284	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
886293016285	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293016286	catalytic residues [active]
886293016287	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240
886293016288	hinge region; other site
886293016289	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
886293016290	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
886293016291	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955
886293016292	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293016293	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293016294	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293016295	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293016296	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
886293016297	nucleophilic elbow; other site
886293016298	catalytic triad; other site
886293016299	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
886293016300	active site
886293016301	catalytic triad [active]
886293016302	oxyanion hole [active]
886293016303	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293016304	HEAT repeats; Region: HEAT_2; pfam13646
886293016305	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
886293016306	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
886293016307	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293016308	Cytochrome c; Region: Cytochrom_C; pfam00034
886293016309	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293016310	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293016311	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293016312	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
886293016313	Phosphotransferase enzyme family; Region: APH; pfam01636
886293016314	active site
886293016315	ATP binding site [chemical binding]; other site
886293016316	substrate binding site [chemical binding]; other site
886293016317	dimer interface [polypeptide binding]; other site
886293016318	phosphoethanolamine N-methyltransferase; Provisional; Region: PTZ00098
886293016319	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293016320	S-adenosylmethionine binding site [chemical binding]; other site
886293016321	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
886293016322	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
886293016323	putative active site [active]
886293016324	putative NTP binding site [chemical binding]; other site
886293016325	putative nucleic acid binding site [nucleotide binding]; other site
886293016326	Esterase/lipase [General function prediction only]; Region: COG1647
886293016327	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293016328	Matrixin; Region: Peptidase_M10; pfam00413
886293016329	active site
886293016330	RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984
886293016331	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
886293016332	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
886293016333	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293016334	putative catalytic residue [active]
886293016335	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
886293016336	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
886293016337	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
886293016338	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
886293016339	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
886293016340	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293016341	prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294
886293016342	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
886293016343	TrkA-N domain; Region: TrkA_N; pfam02254
886293016344	TrkA-C domain; Region: TrkA_C; pfam02080
886293016345	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
886293016346	oxyanion hole [active]
886293016347	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293016348	TPR repeat; Region: TPR_11; pfam13414
886293016349	TPR motif; other site
886293016350	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
886293016351	catalytic triad [active]
886293016352	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
886293016353	anti sigma factor interaction site; other site
886293016354	regulatory phosphorylation site [posttranslational modification]; other site
886293016355	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
886293016356	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
886293016357	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
886293016358	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293016359	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293016360	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293016361	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293016362	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293016363	structural tetrad; other site
886293016364	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
886293016365	HEAT repeats; Region: HEAT_2; pfam13646
886293016366	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
886293016367	Cytochrome c; Region: Cytochrom_C; pfam00034
886293016368	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
886293016369	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
886293016370	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
886293016371	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293016372	dimerization interface [polypeptide binding]; other site
886293016373	putative DNA binding site [nucleotide binding]; other site
886293016374	putative Zn2+ binding site [ion binding]; other site
886293016375	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
886293016376	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347
886293016377	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
886293016378	active site
886293016379	catalytic site [active]
886293016380	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293016381	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293016382	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
886293016383	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293016384	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293016385	active site
886293016386	ATP binding site [chemical binding]; other site
886293016387	substrate binding site [chemical binding]; other site
886293016388	activation loop (A-loop); other site
886293016389	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293016390	TPR motif; other site
886293016391	binding surface
886293016392	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293016393	binding surface
886293016394	TPR motif; other site
886293016395	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
886293016396	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293016397	TPR motif; other site
886293016398	binding surface
886293016399	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293016400	binding surface
886293016401	TPR motif; other site
886293016402	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293016403	binding surface
886293016404	TPR motif; other site
886293016405	Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]; Region: IQG1; COG5261
886293016406	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
886293016407	MbtH-like protein; Region: MbtH; cl01279
886293016408	acyl-CoA synthetase; Validated; Region: PRK05850
886293016409	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
886293016410	acyl-activating enzyme (AAE) consensus motif; other site
886293016411	active site
886293016412	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
886293016413	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
886293016414	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
886293016415	active site
886293016416	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
886293016417	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
886293016418	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
886293016419	KR domain; Region: KR; pfam08659
886293016420	putative NADP binding site [chemical binding]; other site
886293016421	active site
886293016422	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
886293016423	Condensation domain; Region: Condensation; pfam00668
886293016424	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
886293016425	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
886293016426	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
886293016427	acyl-activating enzyme (AAE) consensus motif; other site
886293016428	AMP binding site [chemical binding]; other site
886293016429	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
886293016430	Condensation domain; Region: Condensation; pfam00668
886293016431	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
886293016432	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
886293016433	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
886293016434	acyl-activating enzyme (AAE) consensus motif; other site
886293016435	AMP binding site [chemical binding]; other site
886293016436	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
886293016437	Condensation domain; Region: Condensation; pfam00668
886293016438	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
886293016439	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
886293016440	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
886293016441	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
886293016442	acyl-activating enzyme (AAE) consensus motif; other site
886293016443	AMP binding site [chemical binding]; other site
886293016444	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
886293016445	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
886293016446	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
886293016447	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
886293016448	acyl-activating enzyme (AAE) consensus motif; other site
886293016449	AMP binding site [chemical binding]; other site
886293016450	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
886293016451	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
886293016452	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
886293016453	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
886293016454	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
886293016455	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
886293016456	Walker A/P-loop; other site
886293016457	ATP binding site [chemical binding]; other site
886293016458	Q-loop/lid; other site
886293016459	ABC transporter signature motif; other site
886293016460	Walker B; other site
886293016461	D-loop; other site
886293016462	H-loop/switch region; other site
886293016463	macrolide transporter subunit MacA; Provisional; Region: PRK11578
886293016464	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
886293016465	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293016466	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
886293016467	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
886293016468	Walker A/P-loop; other site
886293016469	ATP binding site [chemical binding]; other site
886293016470	Q-loop/lid; other site
886293016471	ABC transporter signature motif; other site
886293016472	Walker B; other site
886293016473	D-loop; other site
886293016474	H-loop/switch region; other site
886293016475	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
886293016476	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
886293016477	FtsX-like permease family; Region: FtsX; pfam02687
886293016478	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
886293016479	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
886293016480	dimer interface [polypeptide binding]; other site
886293016481	active site
886293016482	Trm112p-like protein; Region: Trm112p; cl01066
886293016483	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
886293016484	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
886293016485	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
886293016486	active site
886293016487	metal binding site [ion binding]; metal-binding site
886293016488	Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162
886293016489	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
886293016490	active site
886293016491	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
886293016492	Colicin V production protein; Region: Colicin_V; pfam02674
886293016493	S4 domain; Region: S4_2; pfam13275
886293016494	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
886293016495	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
886293016496	active site
886293016497	ADP/pyrophosphate binding site [chemical binding]; other site
886293016498	dimerization interface [polypeptide binding]; other site
886293016499	allosteric effector site; other site
886293016500	fructose-1,6-bisphosphate binding site; other site
886293016501	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
886293016502	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
886293016503	PSP1 C-terminal conserved region; Region: PSP1; cl00770
886293016504	Verruc_Plancto-restricted protein; Region: Plancto_Ver_chp; TIGR04138
886293016505	Methyltransferase domain; Region: Methyltransf_23; pfam13489
886293016506	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293016507	S-adenosylmethionine binding site [chemical binding]; other site
886293016508	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
886293016509	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293016510	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293016511	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293016512	DNA binding residues [nucleotide binding]
886293016513	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293016514	Cna protein B-type domain; Region: Cna_B_2; pfam13715
886293016515	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
886293016516	putative hydrophobic ligand binding site [chemical binding]; other site
886293016517	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
886293016518	dimerization interface [polypeptide binding]; other site
886293016519	putative DNA binding site [nucleotide binding]; other site
886293016520	putative Zn2+ binding site [ion binding]; other site
886293016521	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293016522	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
886293016523	Protein of unknown function (DUF3900); Region: DUF3900; pfam13039
886293016524	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
886293016525	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
886293016526	Soluble P-type ATPase [General function prediction only]; Region: COG4087
886293016527	HflK protein; Region: hflK; TIGR01933
886293016528	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
886293016529	HflC protein; Region: hflC; TIGR01932
886293016530	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
886293016531	HflK protein; Region: hflK; TIGR01933
886293016532	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
886293016533	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
886293016534	active site
886293016535	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
886293016536	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
886293016537	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
886293016538	ATP-grasp domain; Region: ATP-grasp_4; cl17255
886293016539	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
886293016540	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
886293016541	ATP-grasp domain; Region: ATP-grasp_4; cl17255
886293016542	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
886293016543	IMP binding site; other site
886293016544	dimer interface [polypeptide binding]; other site
886293016545	interdomain contacts; other site
886293016546	partial ornithine binding site; other site
886293016547	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
886293016548	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
886293016549	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
886293016550	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
886293016551	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
886293016552	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293016553	active site
886293016554	phosphorylation site [posttranslational modification]
886293016555	intermolecular recognition site; other site
886293016556	dimerization interface [polypeptide binding]; other site
886293016557	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293016558	Walker A motif; other site
886293016559	ATP binding site [chemical binding]; other site
886293016560	Walker B motif; other site
886293016561	arginine finger; other site
886293016562	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
886293016563	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293016564	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
886293016565	dimerization interface [polypeptide binding]; other site
886293016566	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293016567	ATP binding site [chemical binding]; other site
886293016568	Mg2+ binding site [ion binding]; other site
886293016569	G-X-G motif; other site
886293016570	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
886293016571	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293016572	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293016573	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
886293016574	Penicillinase repressor; Region: Pencillinase_R; pfam03965
886293016575	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
886293016576	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
886293016577	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293016578	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293016579	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
886293016580	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
886293016581	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353
886293016582	Trehalose utilisation; Region: ThuA; pfam06283
886293016583	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
886293016584	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
886293016585	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
886293016586	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293016587	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293016588	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293016589	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
886293016590	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293016591	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293016592	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
886293016593	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293016594	Sulfatase; Region: Sulfatase; pfam00884
886293016595	Homeodomain-like domain; Region: HTH_23; pfam13384
886293016596	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293016597	S-adenosylmethionine binding site [chemical binding]; other site
886293016598	methionine sulfoxide reductase B; Provisional; Region: PRK05508
886293016599	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
886293016600	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293016601	Sulfatase; Region: Sulfatase; pfam00884
886293016602	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
886293016603	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
886293016604	active site
886293016605	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
886293016606	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293016607	active site
886293016608	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
886293016609	Strictosidine synthase; Region: Str_synth; pfam03088
886293016610	CHASE3 domain; Region: CHASE3; pfam05227
886293016611	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
886293016612	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293016613	putative active site [active]
886293016614	heme pocket [chemical binding]; other site
886293016615	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293016616	dimer interface [polypeptide binding]; other site
886293016617	phosphorylation site [posttranslational modification]
886293016618	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293016619	ATP binding site [chemical binding]; other site
886293016620	Mg2+ binding site [ion binding]; other site
886293016621	G-X-G motif; other site
886293016622	Response regulator receiver domain; Region: Response_reg; pfam00072
886293016623	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293016624	active site
886293016625	phosphorylation site [posttranslational modification]
886293016626	intermolecular recognition site; other site
886293016627	dimerization interface [polypeptide binding]; other site
886293016628	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
886293016629	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293016630	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
886293016631	Acyltransferase family; Region: Acyl_transf_3; pfam01757
886293016632	Sulfatase; Region: Sulfatase; cl17466
886293016633	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
886293016634	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
886293016635	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
886293016636	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
886293016637	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
886293016638	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293016639	Kelch domain; Region: Kelch; smart00612
886293016640	Kelch motif; Region: Kelch_1; pfam01344
886293016641	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
886293016642	Kelch domain; Region: Kelch; smart00612
886293016643	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293016644	hypothetical protein; Validated; Region: PRK00124
886293016645	2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633
886293016646	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
886293016647	putative substrate translocation pore; other site
886293016648	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
886293016649	putative acyl-acceptor binding pocket; other site
886293016650	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
886293016651	acyl-activating enzyme (AAE) consensus motif; other site
886293016652	AMP binding site [chemical binding]; other site
886293016653	active site
886293016654	CoA binding site [chemical binding]; other site
886293016655	1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296
886293016656	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
886293016657	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
886293016658	catalytic site [active]
886293016659	active site
886293016660	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
886293016661	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
886293016662	putative catalytic site [active]
886293016663	putative metal binding site [ion binding]; other site
886293016664	putative phosphate binding site [ion binding]; other site
886293016665	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
886293016666	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
886293016667	catalytic residues [active]
886293016668	Cupin; Region: Cupin_6; pfam12852
886293016669	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293016670	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
886293016671	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293016672	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
886293016673	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
886293016674	putative NAD(P) binding site [chemical binding]; other site
886293016675	Amidohydrolase; Region: Amidohydro_2; pfam04909
886293016676	Protein of unknown function (DUF796); Region: DUF796; pfam05638
886293016677	YCII-related domain; Region: YCII; cl00999
886293016678	Family description; Region: VCBS; pfam13517
886293016679	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
886293016680	Family description; Region: VCBS; pfam13517
886293016681	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
886293016682	MgtC family; Region: MgtC; pfam02308
886293016683	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
886293016684	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
886293016685	putative acyl-acceptor binding pocket; other site
886293016686	Cytidylyltransferase family; Region: CTP_transf_1; cl17467
886293016687	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
886293016688	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
886293016689	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
886293016690	Ferritin-like domain; Region: Ferritin; pfam00210
886293016691	ferroxidase diiron center [ion binding]; other site
886293016692	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
886293016693	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293016694	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
886293016695	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
886293016696	multidrug efflux system protein MdtE; Provisional; Region: PRK09859
886293016697	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
886293016698	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293016699	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
886293016700	Protein export membrane protein; Region: SecD_SecF; cl14618
886293016701	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
886293016702	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
886293016703	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
886293016704	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
886293016705	Active site cavity [active]
886293016706	catalytic acid [active]
886293016707	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293016708	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293016709	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293016710	DNA binding residues [nucleotide binding]
886293016711	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
886293016712	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
886293016713	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293016714	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
886293016715	Predicted membrane protein [Function unknown]; Region: COG4270
886293016716	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
886293016717	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
886293016718	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
886293016719	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
886293016720	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
886293016721	Flagellin N-methylase; Region: FliB; cl00497
886293016722	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
886293016723	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
886293016724	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
886293016725	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
886293016726	NAD(P) binding site [chemical binding]; other site
886293016727	active site
886293016728	Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055
886293016729	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
886293016730	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293016731	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293016732	DNA binding residues [nucleotide binding]
886293016733	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
886293016734	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293016735	active site
886293016736	phosphorylation site [posttranslational modification]
886293016737	intermolecular recognition site; other site
886293016738	dimerization interface [polypeptide binding]; other site
886293016739	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293016740	Walker A motif; other site
886293016741	ATP binding site [chemical binding]; other site
886293016742	Walker B motif; other site
886293016743	arginine finger; other site
886293016744	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
886293016745	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
886293016746	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
886293016747	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293016748	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
886293016749	putative active site [active]
886293016750	heme pocket [chemical binding]; other site
886293016751	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293016752	dimer interface [polypeptide binding]; other site
886293016753	phosphorylation site [posttranslational modification]
886293016754	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293016755	ATP binding site [chemical binding]; other site
886293016756	Mg2+ binding site [ion binding]; other site
886293016757	G-X-G motif; other site
886293016758	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293016759	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293016760	active site
886293016761	phosphorylation site [posttranslational modification]
886293016762	intermolecular recognition site; other site
886293016763	dimerization interface [polypeptide binding]; other site
886293016764	Response regulator receiver domain; Region: Response_reg; pfam00072
886293016765	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293016766	active site
886293016767	phosphorylation site [posttranslational modification]
886293016768	intermolecular recognition site; other site
886293016769	dimerization interface [polypeptide binding]; other site
886293016770	hypothetical protein; Provisional; Region: PRK06184
886293016771	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
886293016772	Rrf2 family protein; Region: rrf2_super; TIGR00738
886293016773	Transcriptional regulator; Region: Rrf2; pfam02082
886293016774	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
886293016775	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
886293016776	homodimer interface [polypeptide binding]; other site
886293016777	substrate-cofactor binding pocket; other site
886293016778	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293016779	catalytic residue [active]
886293016780	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
886293016781	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
886293016782	dimer interface [polypeptide binding]; other site
886293016783	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293016784	catalytic residue [active]
886293016785	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
886293016786	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
886293016787	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293016788	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
886293016789	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293016790	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
886293016791	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
886293016792	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
886293016793	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
886293016794	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
886293016795	Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712
886293016796	Tetratricopeptide repeat; Region: TPR_16; pfam13432
886293016797	Family description; Region: VCBS; pfam13517
886293016798	Family description; Region: VCBS; pfam13517
886293016799	Family description; Region: VCBS; pfam13517
886293016800	Family description; Region: VCBS; pfam13517
886293016801	Family description; Region: VCBS; pfam13517
886293016802	Family description; Region: VCBS; pfam13517
886293016803	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
886293016804	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293016805	Isochorismatase family; Region: Isochorismatase; pfam00857
886293016806	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
886293016807	catalytic triad [active]
886293016808	conserved cis-peptide bond; other site
886293016809	DDE superfamily endonuclease; Region: DDE_5; cl17874
886293016810	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293016811	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
886293016812	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
886293016813	Bacterial Ig-like domain; Region: Big_5; pfam13205
886293016814	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
886293016815	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
886293016816	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
886293016817	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
886293016818	active site
886293016819	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
886293016820	Cation efflux family; Region: Cation_efflux; pfam01545
886293016821	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293016822	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293016823	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293016824	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293016825	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
886293016826	HEAT repeats; Region: HEAT_2; pfam13646
886293016827	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
886293016828	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
886293016829	metal ion-dependent adhesion site (MIDAS); other site
886293016830	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
886293016831	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293016832	active site
886293016833	phosphorylation site [posttranslational modification]
886293016834	intermolecular recognition site; other site
886293016835	dimerization interface [polypeptide binding]; other site
886293016836	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
886293016837	DNA binding site [nucleotide binding]
886293016838	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293016839	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293016840	dimer interface [polypeptide binding]; other site
886293016841	phosphorylation site [posttranslational modification]
886293016842	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293016843	Mg2+ binding site [ion binding]; other site
886293016844	G-X-G motif; other site
886293016845	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
886293016846	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
886293016847	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
886293016848	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
886293016849	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
886293016850	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
886293016851	tartrate dehydrogenase; Region: TTC; TIGR02089
886293016852	Outer membrane efflux protein; Region: OEP; pfam02321
886293016853	Outer membrane efflux protein; Region: OEP; pfam02321
886293016854	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293016855	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293016856	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
886293016857	Domain of unknown function (DUF303); Region: DUF303; pfam03629
886293016858	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293016859	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293016860	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293016861	DNA binding residues [nucleotide binding]
886293016862	Right handed beta helix region; Region: Beta_helix; pfam13229
886293016863	Right handed beta helix region; Region: Beta_helix; pfam13229
886293016864	PhoD-like phosphatase; Region: PhoD; pfam09423
886293016865	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
886293016866	putative active site [active]
886293016867	putative metal binding site [ion binding]; other site
886293016868	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
886293016869	DDE superfamily endonuclease; Region: DDE_5; cl17874
886293016870	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293016871	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293016872	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293016873	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293016874	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293016875	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293016876	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
886293016877	RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989
886293016878	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293016879	FecR protein; Region: FecR; pfam04773
886293016880	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
886293016881	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293016882	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
886293016883	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
886293016884	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
886293016885	putative active site [active]
886293016886	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
886293016887	active site residue [active]
886293016888	Methylamine utilisation protein MauE; Region: MauE; pfam07291
886293016889	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
886293016890	Predicted membrane protein [Function unknown]; Region: COG3463
886293016891	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
886293016892	Sulfatase; Region: Sulfatase; pfam00884
886293016893	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
886293016894	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
886293016895	ligand binding site [chemical binding]; other site
886293016896	flexible hinge region; other site
886293016897	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
886293016898	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
886293016899	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
886293016900	active site
886293016901	allosteric site; other site
886293016902	trimer interface [polypeptide binding]; other site
886293016903	active site lid [active]
886293016904	hexamer (dimer of trimers) interface [polypeptide binding]; other site
886293016905	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
886293016906	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
886293016907	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
886293016908	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
886293016909	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
886293016910	Trp docking motif [polypeptide binding]; other site
886293016911	putative active site [active]
886293016912	Methyltransferase domain; Region: Methyltransf_23; pfam13489
886293016913	Methyltransferase domain; Region: Methyltransf_12; pfam08242
886293016914	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
886293016915	Ligand binding site; other site
886293016916	Putative Catalytic site; other site
886293016917	DXD motif; other site
886293016918	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
886293016919	2-isopropylmalate synthase; Validated; Region: PRK00915
886293016920	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
886293016921	active site
886293016922	catalytic residues [active]
886293016923	metal binding site [ion binding]; metal-binding site
886293016924	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
886293016925	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
886293016926	PEP-CTERM motif; Region: VPEP; pfam07589
886293016927	PEP-CTERM motif; Region: VPEP; pfam07589
886293016928	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
886293016929	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
886293016930	ATP binding site [chemical binding]; other site
886293016931	putative Mg++ binding site [ion binding]; other site
886293016932	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
886293016933	ATP-binding site [chemical binding]; other site
886293016934	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
886293016935	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
886293016936	active site
886293016937	(T/H)XGH motif; other site
886293016938	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
886293016939	putative active site [active]
886293016940	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293016941	dimer interface [polypeptide binding]; other site
886293016942	phosphorylation site [posttranslational modification]
886293016943	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293016944	ATP binding site [chemical binding]; other site
886293016945	Mg2+ binding site [ion binding]; other site
886293016946	G-X-G motif; other site
886293016947	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
886293016948	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
886293016949	TPR repeat; Region: TPR_11; pfam13414
886293016950	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293016951	binding surface
886293016952	TPR motif; other site
886293016953	TPR repeat; Region: TPR_11; pfam13414
886293016954	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293016955	binding surface
886293016956	Tetratricopeptide repeat; Region: TPR_16; pfam13432
886293016957	TPR motif; other site
886293016958	TPR repeat; Region: TPR_11; pfam13414
886293016959	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
886293016960	binding surface
886293016961	TPR motif; other site
886293016962	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
886293016963	active site
886293016964	HIGH motif; other site
886293016965	dimer interface [polypeptide binding]; other site
886293016966	KMSKS motif; other site
886293016967	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
886293016968	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
886293016969	Serine hydrolase (FSH1); Region: FSH1; pfam03959
886293016970	Flagellin N-methylase; Region: FliB; pfam03692
886293016971	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
886293016972	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
886293016973	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
886293016974	Competence protein; Region: Competence; pfam03772
886293016975	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
886293016976	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
886293016977	enolase; Provisional; Region: eno; PRK00077
886293016978	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
886293016979	dimer interface [polypeptide binding]; other site
886293016980	metal binding site [ion binding]; metal-binding site
886293016981	substrate binding pocket [chemical binding]; other site
886293016982	Phosphotransferase enzyme family; Region: APH; pfam01636
886293016983	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
886293016984	substrate binding site [chemical binding]; other site
886293016985	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
886293016986	hydroxyglutarate oxidase; Provisional; Region: PRK11728
886293016987	Glycosyl transferase family 90; Region: Glyco_transf_90; pfam05686
886293016988	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293016989	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293016990	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293016991	Trehalose utilisation; Region: ThuA; pfam06283
886293016992	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
886293016993	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
886293016994	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
886293016995	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
886293016996	PAS fold; Region: PAS_4; pfam08448
886293016997	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
886293016998	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
886293016999	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
886293017000	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293017001	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
886293017002	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
886293017003	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
886293017004	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
886293017005	Transcriptional regulators [Transcription]; Region: MarR; COG1846
886293017006	MarR family; Region: MarR_2; pfam12802
886293017007	Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056
886293017008	RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984
886293017009	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293017010	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293017011	DNA binding residues [nucleotide binding]
886293017012	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
886293017013	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293017014	active site
886293017015	ATP binding site [chemical binding]; other site
886293017016	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293017017	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293017018	substrate binding site [chemical binding]; other site
886293017019	activation loop (A-loop); other site
886293017020	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293017021	structural tetrad; other site
886293017022	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293017023	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293017024	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293017025	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
886293017026	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293017027	S-adenosylmethionine binding site [chemical binding]; other site
886293017028	Homeodomain-like domain; Region: HTH_23; pfam13384
886293017029	Winged helix-turn helix; Region: HTH_29; pfam13551
886293017030	DDE superfamily endonuclease; Region: DDE_3; pfam13358
886293017031	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
886293017032	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
886293017033	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
886293017034	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293017035	S-adenosylmethionine binding site [chemical binding]; other site
886293017036	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
886293017037	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
886293017038	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
886293017039	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293017040	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
886293017041	active site
886293017042	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
886293017043	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
886293017044	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293017045	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293017046	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
886293017047	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
886293017048	Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417
886293017049	PAS domain S-box; Region: sensory_box; TIGR00229
886293017050	PAS domain; Region: PAS; smart00091
886293017051	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
886293017052	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
886293017053	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293017054	PAS fold; Region: PAS_3; pfam08447
886293017055	putative active site [active]
886293017056	heme pocket [chemical binding]; other site
886293017057	GAF domain; Region: GAF; pfam01590
886293017058	GAF domain; Region: GAF_2; pfam13185
886293017059	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293017060	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293017061	dimer interface [polypeptide binding]; other site
886293017062	phosphorylation site [posttranslational modification]
886293017063	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293017064	ATP binding site [chemical binding]; other site
886293017065	Mg2+ binding site [ion binding]; other site
886293017066	G-X-G motif; other site
886293017067	Response regulator receiver domain; Region: Response_reg; pfam00072
886293017068	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293017069	active site
886293017070	phosphorylation site [posttranslational modification]
886293017071	intermolecular recognition site; other site
886293017072	dimerization interface [polypeptide binding]; other site
886293017073	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
886293017074	Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576
886293017075	putative ligand binding site [chemical binding]; other site
886293017076	putative catalytic site [active]
886293017077	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
886293017078	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
886293017079	ferrochelatase; Region: hemH; TIGR00109
886293017080	Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844
886293017081	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
886293017082	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
886293017083	cheY-homologous receiver domain; Region: REC; smart00448
886293017084	phosphorylation site [posttranslational modification]
886293017085	GAF domain; Region: GAF; cl17456
886293017086	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293017087	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293017088	ATP binding site [chemical binding]; other site
886293017089	Mg2+ binding site [ion binding]; other site
886293017090	G-X-G motif; other site
886293017091	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293017092	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293017093	DNA binding residues [nucleotide binding]
886293017094	Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478
886293017095	active site
886293017096	catalytic triad [active]
886293017097	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
886293017098	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
886293017099	domain interfaces; other site
886293017100	active site
886293017101	HEPN domain; Region: HEPN; cl00824
886293017102	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
886293017103	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293017104	non-specific DNA binding site [nucleotide binding]; other site
886293017105	salt bridge; other site
886293017106	sequence-specific DNA binding site [nucleotide binding]; other site
886293017107	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
886293017108	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
886293017109	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
886293017110	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
886293017111	Na binding site [ion binding]; other site
886293017112	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293017113	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
886293017114	active site
886293017115	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
886293017116	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
886293017117	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
886293017118	metal binding site [ion binding]; metal-binding site
886293017119	substrate binding pocket [chemical binding]; other site
886293017120	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
886293017121	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
886293017122	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293017123	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
886293017124	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
886293017125	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
886293017126	histidinol dehydrogenase; Region: hisD; TIGR00069
886293017127	NAD binding site [chemical binding]; other site
886293017128	dimerization interface [polypeptide binding]; other site
886293017129	product binding site; other site
886293017130	substrate binding site [chemical binding]; other site
886293017131	zinc binding site [ion binding]; other site
886293017132	catalytic residues [active]
886293017133	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
886293017134	G1 box; other site
886293017135	GTP/Mg2+ binding site [chemical binding]; other site
886293017136	G2 box; other site
886293017137	Switch I region; other site
886293017138	G3 box; other site
886293017139	Switch II region; other site
886293017140	G4 box; other site
886293017141	C2 domain; Region: C2; cl14603
886293017142	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293017143	S-adenosylmethionine binding site [chemical binding]; other site
886293017144	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
886293017145	DNA-binding site [nucleotide binding]; DNA binding site
886293017146	Transcriptional regulators [Transcription]; Region: FadR; COG2186
886293017147	FCD domain; Region: FCD; pfam07729
886293017148	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293017149	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
886293017150	anti sigma factor interaction site; other site
886293017151	regulatory phosphorylation site [posttranslational modification]; other site
886293017152	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293017153	structural tetrad; other site
886293017154	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293017155	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293017156	ECF sigma factor; Region: Sigma70_ECF; pfam07638
886293017157	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
886293017158	DNA binding residues [nucleotide binding]
886293017159	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293017160	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293017161	active site
886293017162	ATP binding site [chemical binding]; other site
886293017163	substrate binding site [chemical binding]; other site
886293017164	activation loop (A-loop); other site
886293017165	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293017166	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293017167	structural tetrad; other site
886293017168	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
886293017169	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
886293017170	dimer interface [polypeptide binding]; other site
886293017171	DoxX-like family; Region: DoxX_2; pfam13564
886293017172	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
886293017173	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
886293017174	FMN binding site [chemical binding]; other site
886293017175	substrate binding site [chemical binding]; other site
886293017176	putative catalytic residue [active]
886293017177	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
886293017178	dimerization interface [polypeptide binding]; other site
886293017179	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293017180	dimer interface [polypeptide binding]; other site
886293017181	phosphorylation site [posttranslational modification]
886293017182	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293017183	ATP binding site [chemical binding]; other site
886293017184	Mg2+ binding site [ion binding]; other site
886293017185	G-X-G motif; other site
886293017186	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293017187	Response regulator receiver domain; Region: Response_reg; pfam00072
886293017188	active site
886293017189	phosphorylation site [posttranslational modification]
886293017190	intermolecular recognition site; other site
886293017191	dimerization interface [polypeptide binding]; other site
886293017192	Response regulator receiver domain; Region: Response_reg; pfam00072
886293017193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293017194	active site
886293017195	phosphorylation site [posttranslational modification]
886293017196	intermolecular recognition site; other site
886293017197	dimerization interface [polypeptide binding]; other site
886293017198	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
886293017199	putative binding surface; other site
886293017200	active site
886293017201	Response regulator receiver domain; Region: Response_reg; pfam00072
886293017202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293017203	active site
886293017204	phosphorylation site [posttranslational modification]
886293017205	intermolecular recognition site; other site
886293017206	dimerization interface [polypeptide binding]; other site
886293017207	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293017208	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293017209	dimer interface [polypeptide binding]; other site
886293017210	phosphorylation site [posttranslational modification]
886293017211	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293017212	ATP binding site [chemical binding]; other site
886293017213	Mg2+ binding site [ion binding]; other site
886293017214	G-X-G motif; other site
886293017215	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293017216	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293017217	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
886293017218	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293017219	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
886293017220	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293017221	DNA binding residues [nucleotide binding]
886293017222	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
886293017223	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
886293017224	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
886293017225	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
886293017226	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
886293017227	FHIPEP family; Region: FHIPEP; pfam00771
886293017228	Winged helix-turn helix; Region: HTH_29; pfam13551
886293017229	Homeodomain-like domain; Region: HTH_32; pfam13565
886293017230	Integrase core domain; Region: rve; pfam00665
886293017231	Integrase core domain; Region: rve_3; cl15866
886293017232	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
886293017233	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
886293017234	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
886293017235	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
886293017236	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
886293017237	FliG C-terminal domain; Region: FliG_C; pfam01706
886293017238	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
886293017239	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
886293017240	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
886293017241	putative active site [active]
886293017242	putative NTP binding site [chemical binding]; other site
886293017243	putative nucleic acid binding site [nucleotide binding]; other site
886293017244	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
886293017245	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
886293017246	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
886293017247	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
886293017248	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
886293017249	active site
886293017250	catalytic triad [active]
886293017251	oxyanion hole [active]
886293017252	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
886293017253	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
886293017254	acyl-activating enzyme (AAE) consensus motif; other site
886293017255	AMP binding site [chemical binding]; other site
886293017256	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
886293017257	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
886293017258	putative acyl-acceptor binding pocket; other site
886293017259	Uncharacterized conserved protein [Function unknown]; Region: COG3391
886293017260	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
886293017261	tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791
886293017262	Cytochrome c; Region: Cytochrom_C; pfam00034
886293017263	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
886293017264	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
886293017265	Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757
886293017266	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
886293017267	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293017268	Transposase [DNA replication, recombination, and repair]; Region: COG5433
886293017269	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
886293017270	DDE superfamily endonuclease; Region: DDE_5; cl17874
886293017271	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
886293017272	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
886293017273	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
886293017274	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
886293017275	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
886293017276	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
886293017277	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
886293017278	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293017279	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293017280	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293017281	catalytic residues [active]
886293017282	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
886293017283	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
886293017284	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
886293017285	DDE domain; Region: DDE_Tnp_IS240; pfam13610
886293017286	Cna protein B-type domain; Region: Cna_B_2; pfam13715
886293017287	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293017288	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293017289	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293017290	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293017291	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293017292	DNA binding residues [nucleotide binding]
886293017293	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
886293017294	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
886293017295	generic binding surface II; other site
886293017296	generic binding surface I; other site
886293017297	Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601
886293017298	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
886293017299	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
886293017300	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
886293017301	substrate binding pocket [chemical binding]; other site
886293017302	chain length determination region; other site
886293017303	substrate-Mg2+ binding site; other site
886293017304	catalytic residues [active]
886293017305	aspartate-rich region 1; other site
886293017306	active site lid residues [active]
886293017307	aspartate-rich region 2; other site
886293017308	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
886293017309	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
886293017310	TPP-binding site; other site
886293017311	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
886293017312	PYR/PP interface [polypeptide binding]; other site
886293017313	dimer interface [polypeptide binding]; other site
886293017314	TPP binding site [chemical binding]; other site
886293017315	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
886293017316	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
886293017317	ATP-NAD kinase; Region: NAD_kinase; pfam01513
886293017318	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
886293017319	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
886293017320	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
886293017321	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
886293017322	TilS substrate C-terminal domain; Region: TilS_C; smart00977
886293017323	Cupin domain; Region: Cupin_2; cl17218
886293017324	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
886293017325	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
886293017326	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
886293017327	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293017328	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293017329	active site
886293017330	ATP binding site [chemical binding]; other site
886293017331	substrate binding site [chemical binding]; other site
886293017332	activation loop (A-loop); other site
886293017333	ECF sigma factor; Region: Sigma70_ECF; pfam07638
886293017334	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293017335	DNA binding residues [nucleotide binding]
886293017336	Cupin; Region: Cupin_1; smart00835
886293017337	Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140
886293017338	Cupin; Region: Cupin_1; smart00835
886293017339	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
886293017340	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
886293017341	putative molybdopterin cofactor binding site [chemical binding]; other site
886293017342	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
886293017343	molybdopterin cofactor binding site; other site
886293017344	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
886293017345	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
886293017346	HlyD family secretion protein; Region: HlyD_3; pfam13437
886293017347	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
886293017348	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
886293017349	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
886293017350	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
886293017351	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
886293017352	active site
886293017353	ATP binding site [chemical binding]; other site
886293017354	substrate binding site [chemical binding]; other site
886293017355	activation loop (A-loop); other site
886293017356	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293017357	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293017358	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293017359	structural tetrad; other site
886293017360	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293017361	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293017362	structural tetrad; other site
886293017363	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293017364	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
886293017365	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
886293017366	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
886293017367	putative ADP-binding pocket [chemical binding]; other site
886293017368	Catalytic domain of Protein Kinases; Region: PKc; cd00180
886293017369	active site
886293017370	ATP binding site [chemical binding]; other site
886293017371	substrate binding site [chemical binding]; other site
886293017372	activation loop (A-loop); other site
886293017373	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293017374	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293017375	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
886293017376	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293017377	structural tetrad; other site
886293017378	FOG: WD40 repeat [General function prediction only]; Region: COG2319
886293017379	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
886293017380	structural tetrad; other site
886293017381	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293017382	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293017383	catalytic residues [active]
886293017384	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
886293017385	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
886293017386	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293017387	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293017388	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293017389	DNA binding residues [nucleotide binding]
886293017390	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
886293017391	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
886293017392	Strictosidine synthase; Region: Str_synth; pfam03088
886293017393	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
886293017394	TadE-like protein; Region: TadE; pfam07811
886293017395	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
886293017396	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
886293017397	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
886293017398	Walker A/P-loop; other site
886293017399	ATP binding site [chemical binding]; other site
886293017400	Q-loop/lid; other site
886293017401	ABC transporter signature motif; other site
886293017402	Walker B; other site
886293017403	D-loop; other site
886293017404	H-loop/switch region; other site
886293017405	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
886293017406	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293017407	conserved repeat domain; Region: B_ant_repeat; TIGR01451
886293017408	conserved repeat domain; Region: B_ant_repeat; TIGR01451
886293017409	Domain of unknown function DUF11; Region: DUF11; pfam01345
886293017410	conserved repeat domain; Region: B_ant_repeat; TIGR01451
886293017411	Domain of unknown function DUF11; Region: DUF11; pfam01345
886293017412	Domain of unknown function DUF11; Region: DUF11; pfam01345
886293017413	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
886293017414	Beta-lactamase; Region: Beta-lactamase; pfam00144
886293017415	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293017416	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293017417	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
886293017418	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293017419	The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693
886293017420	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
886293017421	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
886293017422	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
886293017423	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293017424	non-specific DNA binding site [nucleotide binding]; other site
886293017425	salt bridge; other site
886293017426	sequence-specific DNA binding site [nucleotide binding]; other site
886293017427	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
886293017428	inhibitor binding site; inhibition site
886293017429	catalytic motif [active]
886293017430	Catalytic residue [active]
886293017431	Active site flap [active]
886293017432	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
886293017433	HEAT repeats; Region: HEAT_2; pfam13646
886293017434	protein binding surface [polypeptide binding]; other site
886293017435	HEAT repeats; Region: HEAT_2; pfam13646
886293017436	HEAT repeats; Region: HEAT_2; pfam13646
886293017437	HEAT repeats; Region: HEAT_2; pfam13646
886293017438	HEAT repeats; Region: HEAT_2; pfam13646
886293017439	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
886293017440	HEAT repeats; Region: HEAT_2; pfam13646
886293017441	protein binding surface [polypeptide binding]; other site
886293017442	HEAT repeats; Region: HEAT_2; pfam13646
886293017443	HEAT repeats; Region: HEAT_2; pfam13646
886293017444	HEAT repeats; Region: HEAT_2; pfam13646
886293017445	HEAT repeats; Region: HEAT_2; pfam13646
886293017446	HEAT repeats; Region: HEAT_2; pfam13646
886293017447	HEAT repeats; Region: HEAT_2; pfam13646
886293017448	HEAT repeats; Region: HEAT_2; pfam13646
886293017449	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
886293017450	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
886293017451	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
886293017452	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
886293017453	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
886293017454	catalytic residues [active]
886293017455	Homeodomain-like domain; Region: HTH_23; pfam13384
886293017456	Winged helix-turn helix; Region: HTH_29; pfam13551
886293017457	Homeodomain-like domain; Region: HTH_32; pfam13565
886293017458	DDE superfamily endonuclease; Region: DDE_3; pfam13358
886293017459	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
886293017460	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
886293017461	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293017462	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
886293017463	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
886293017464	Cna protein B-type domain; Region: Cna_B_2; pfam13715
886293017465	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
886293017466	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
886293017467	enolase; Provisional; Region: eno; PRK00077
886293017468	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
886293017469	dimer interface [polypeptide binding]; other site
886293017470	metal binding site [ion binding]; metal-binding site
886293017471	substrate binding pocket [chemical binding]; other site
886293017472	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293017473	Response regulator receiver domain; Region: Response_reg; pfam00072
886293017474	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293017475	active site
886293017476	phosphorylation site [posttranslational modification]
886293017477	intermolecular recognition site; other site
886293017478	dimerization interface [polypeptide binding]; other site
886293017479	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
886293017480	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
886293017481	ATP binding site [chemical binding]; other site
886293017482	Mg2+ binding site [ion binding]; other site
886293017483	G-X-G motif; other site
886293017484	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
886293017485	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
886293017486	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
886293017487	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
886293017488	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
886293017489	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
886293017490	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
886293017491	active site
886293017492	metal binding site [ion binding]; metal-binding site
886293017493	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
886293017494	putative active site [active]
886293017495	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
886293017496	putative active site [active]
886293017497	MoxR-like ATPases [General function prediction only]; Region: COG0714
886293017498	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
886293017499	Walker A motif; other site
886293017500	ATP binding site [chemical binding]; other site
886293017501	Walker B motif; other site
886293017502	arginine finger; other site
886293017503	Protein of unknown function DUF58; Region: DUF58; pfam01882
886293017504	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
886293017505	metal ion-dependent adhesion site (MIDAS); other site
886293017506	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
886293017507	metal ion-dependent adhesion site (MIDAS); other site
886293017508	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
886293017509	metal ion-dependent adhesion site (MIDAS); other site
886293017510	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293017511	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293017512	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
886293017513	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293017514	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293017515	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
886293017516	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
886293017517	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293017518	Right handed beta helix region; Region: Beta_helix; pfam13229
886293017519	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
886293017520	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
886293017521	Prenyltransferase-like; Region: Prenyltrans_1; pfam13243
886293017522	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
886293017523	MAEBL; Provisional; Region: PTZ00121
886293017524	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
886293017525	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
886293017526	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
886293017527	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
886293017528	active site
886293017529	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
886293017530	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
886293017531	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
886293017532	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
886293017533	tetramer interface [polypeptide binding]; other site
886293017534	pyridoxal 5'-phosphate binding site [chemical binding]; other site
886293017535	catalytic residue [active]
886293017536	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293017537	active site
886293017538	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
886293017539	phosphorylation site [posttranslational modification]
886293017540	intermolecular recognition site; other site
886293017541	dimerization interface [polypeptide binding]; other site
886293017542	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293017543	dimer interface [polypeptide binding]; other site
886293017544	phosphorylation site [posttranslational modification]
886293017545	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293017546	ATP binding site [chemical binding]; other site
886293017547	Mg2+ binding site [ion binding]; other site
886293017548	G-X-G motif; other site
886293017549	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
886293017550	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
886293017551	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293017552	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
886293017553	putative active site [active]
886293017554	heme pocket [chemical binding]; other site
886293017555	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293017556	putative active site [active]
886293017557	heme pocket [chemical binding]; other site
886293017558	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
886293017559	putative active site [active]
886293017560	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
886293017561	heme pocket [chemical binding]; other site
886293017562	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
886293017563	dimer interface [polypeptide binding]; other site
886293017564	phosphorylation site [posttranslational modification]
886293017565	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
886293017566	ATP binding site [chemical binding]; other site
886293017567	Mg2+ binding site [ion binding]; other site
886293017568	G-X-G motif; other site
886293017569	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
886293017570	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293017571	active site
886293017572	phosphorylation site [posttranslational modification]
886293017573	intermolecular recognition site; other site
886293017574	dimerization interface [polypeptide binding]; other site
886293017575	Response regulator receiver domain; Region: Response_reg; pfam00072
886293017576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
886293017577	active site
886293017578	phosphorylation site [posttranslational modification]
886293017579	intermolecular recognition site; other site
886293017580	dimerization interface [polypeptide binding]; other site
886293017581	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
886293017582	putative binding surface; other site
886293017583	active site
886293017584	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
886293017585	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
886293017586	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293017587	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
886293017588	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293017589	DNA binding residues [nucleotide binding]
886293017590	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
886293017591	Domain of unknown function DUF20; Region: UPF0118; pfam01594
886293017592	NlpC/P60 family; Region: NLPC_P60; cl17555
886293017593	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293017594	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
886293017595	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293017596	FecR protein; Region: FecR; pfam04773
886293017597	RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989
886293017598	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293017599	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
886293017600	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293017601	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
886293017602	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
886293017603	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293017604	S-adenosylmethionine binding site [chemical binding]; other site
886293017605	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
886293017606	putative active site [active]
886293017607	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
886293017608	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
886293017609	S-adenosylmethionine binding site [chemical binding]; other site
886293017610	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
886293017611	PhoU domain; Region: PhoU; pfam01895
886293017612	PhoU domain; Region: PhoU; pfam01895
886293017613	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
886293017614	Coenzyme A binding pocket [chemical binding]; other site
886293017615	RNA polymerase sigma factor SigW; Provisional; Region: PRK09641
886293017616	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293017617	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293017618	DNA binding residues [nucleotide binding]
886293017619	Putative zinc-finger; Region: zf-HC2; pfam13490
886293017620	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
886293017621	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
886293017622	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
886293017623	protein binding site [polypeptide binding]; other site
886293017624	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
886293017625	Sulfatase; Region: Sulfatase; cl17466
886293017626	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
886293017627	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
886293017628	P-loop; other site
886293017629	Magnesium ion binding site [ion binding]; other site
886293017630	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
886293017631	Magnesium ion binding site [ion binding]; other site
886293017632	ParB-like nuclease domain; Region: ParB; smart00470
886293017633	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
886293017634	DNA-binding site [nucleotide binding]; DNA binding site
886293017635	Replication initiator protein A; Region: RPA; cl17860
886293017636	RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989
886293017637	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293017638	FecR protein; Region: FecR; pfam04773
886293017639	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
886293017640	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
886293017641	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
886293017642	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
886293017643	substrate binding site; other site
886293017644	tetramer interface; other site
886293017645	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293017646	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
886293017647	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
886293017648	active site
886293017649	DNA binding site [nucleotide binding]
886293017650	Int/Topo IB signature motif; other site
886293017651	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
886293017652	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
886293017653	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
886293017654	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293017655	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293017656	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293017657	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293017658	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
886293017659	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
886293017660	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
886293017661	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
886293017662	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
886293017663	MOSC domain; Region: MOSC; pfam03473
886293017664	3-alpha domain; Region: 3-alpha; pfam03475
886293017665	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
886293017666	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
886293017667	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
886293017668	TPR motif; other site
886293017669	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
886293017670	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
886293017671	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
886293017672	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
886293017673	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
886293017674	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
886293017675	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
886293017676	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
886293017677	Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG4935
886293017678	Family description; Region: VCBS; pfam13517
886293017679	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
886293017680	non-specific DNA binding site [nucleotide binding]; other site
886293017681	salt bridge; other site
886293017682	sequence-specific DNA binding site [nucleotide binding]; other site
886293017683	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
886293017684	Helix-turn-helix domain; Region: HTH_36; pfam13730
886293017685	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
886293017686	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
886293017687	P-loop; other site
886293017688	Magnesium ion binding site [ion binding]; other site
886293017689	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
886293017690	Magnesium ion binding site [ion binding]; other site
886293017691	ParB-like nuclease domain; Region: ParB; smart00470
886293017692	KorB domain; Region: KorB; pfam08535
886293017693	DNA-directed RNA polymerase subunit beta'/alpha domain fusion protein; Provisional; Region: PRK14906
886293017694	DNA-directed RNA polymerase subunit beta'/alpha domain fusion protein; Provisional; Region: PRK14906
886293017695	PemK-like protein; Region: PemK; pfam02452
886293017696	Helix-turn-helix domain; Region: HTH_17; pfam12728
886293017697	Helix-turn-helix domain; Region: HTH_17; pfam12728
886293017698	Helix-turn-helix domain; Region: HTH_17; pfam12728
886293017699	Homeodomain-like domain; Region: HTH_23; pfam13384
886293017700	Winged helix-turn helix; Region: HTH_29; pfam13551
886293017701	Homeodomain-like domain; Region: HTH_32; pfam13565
886293017702	DDE superfamily endonuclease; Region: DDE_3; pfam13358
886293017703	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
886293017704	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
886293017705	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
886293017706	active site
886293017707	metal binding site [ion binding]; metal-binding site
886293017708	interdomain interaction site; other site
886293017709	hypothetical protein; Provisional; Region: PRK14709
886293017710	D5 N terminal like; Region: D5_N; pfam08706
886293017711	5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase-like protein; Provisional; Region: PRK13277
886293017712	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
886293017713	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
886293017714	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
886293017715	DNA binding residues [nucleotide binding]
886293017716	Predicted transcriptional regulators [Transcription]; Region: COG1695
886293017717	Transcriptional regulator PadR-like family; Region: PadR; cl17335
886293017718	ParB-like nuclease domain; Region: ParBc; pfam02195
886293017719	ParB-like nuclease domain; Region: ParB; smart00470
886293017720	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
886293017721	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
886293017722	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
886293017723	Walker A motif; other site
886293017724	ATP binding site [chemical binding]; other site
886293017725	Walker B motif; other site
886293017726	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
886293017727	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
886293017728	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
886293017729	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
886293017730	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
886293017731	Magnesium ion binding site [ion binding]; other site
886293017732	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
886293017733	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
886293017734	active site
886293017735	DNA binding site [nucleotide binding]
886293017736	Int/Topo IB signature motif; other site
886293017737	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
886293017738	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
886293017739	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
886293017740	putative active site [active]
886293017741	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
886293017742	TrwC relaxase; Region: TrwC; pfam08751
886293017743	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
886293017744	AAA domain; Region: AAA_30; pfam13604
886293017745	DNA helicase TraI; Region: TraI; pfam07057