-- dump date 20140620_065943 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1117943000001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1117943000002 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1117943000003 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1117943000004 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1117943000005 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 1117943000006 putative hydrophobic ligand binding site [chemical binding]; other site 1117943000007 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1117943000008 SnoaL-like domain; Region: SnoaL_3; pfam13474 1117943000009 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1117943000010 putative dimer interface [polypeptide binding]; other site 1117943000011 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943000012 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1117943000013 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1117943000014 putative C-terminal domain interface [polypeptide binding]; other site 1117943000015 putative GSH binding site (G-site) [chemical binding]; other site 1117943000016 putative dimer interface [polypeptide binding]; other site 1117943000017 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1117943000018 dimer interface [polypeptide binding]; other site 1117943000019 N-terminal domain interface [polypeptide binding]; other site 1117943000020 putative substrate binding pocket (H-site) [chemical binding]; other site 1117943000021 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 1117943000022 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1117943000023 FeS/SAM binding site; other site 1117943000024 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1117943000025 active site 1117943000026 dimerization interface [polypeptide binding]; other site 1117943000027 ribonuclease PH; Reviewed; Region: rph; PRK00173 1117943000028 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1117943000029 hexamer interface [polypeptide binding]; other site 1117943000030 active site 1117943000031 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1117943000032 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1117943000033 dimer interface [polypeptide binding]; other site 1117943000034 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1117943000035 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1117943000036 FAD binding domain; Region: FAD_binding_4; pfam01565 1117943000037 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1117943000038 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1117943000039 classical (c) SDRs; Region: SDR_c; cd05233 1117943000040 NAD(P) binding site [chemical binding]; other site 1117943000041 active site 1117943000042 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1117943000043 active site 1117943000044 phosphorylation site [posttranslational modification] 1117943000045 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1117943000046 30S subunit binding site; other site 1117943000047 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1117943000048 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1117943000049 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1117943000050 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1117943000051 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1117943000052 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1117943000053 Walker A/P-loop; other site 1117943000054 ATP binding site [chemical binding]; other site 1117943000055 Q-loop/lid; other site 1117943000056 ABC transporter signature motif; other site 1117943000057 Walker B; other site 1117943000058 D-loop; other site 1117943000059 H-loop/switch region; other site 1117943000060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 1117943000061 OstA-like protein; Region: OstA; pfam03968 1117943000062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 1117943000063 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1117943000064 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1117943000065 tandem repeat interface [polypeptide binding]; other site 1117943000066 oligomer interface [polypeptide binding]; other site 1117943000067 active site residues [active] 1117943000068 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1117943000069 IHF dimer interface [polypeptide binding]; other site 1117943000070 IHF - DNA interface [nucleotide binding]; other site 1117943000071 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 1117943000072 putative hydrophobic ligand binding site [chemical binding]; other site 1117943000073 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1117943000074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943000075 S-adenosylmethionine binding site [chemical binding]; other site 1117943000076 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1117943000077 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1117943000078 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1117943000079 lipoprotein signal peptidase; Provisional; Region: PRK14795 1117943000080 lipoprotein signal peptidase; Provisional; Region: PRK14787 1117943000081 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943000082 dimer interface [polypeptide binding]; other site 1117943000083 phosphorylation site [posttranslational modification] 1117943000084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943000085 ATP binding site [chemical binding]; other site 1117943000086 Mg2+ binding site [ion binding]; other site 1117943000087 G-X-G motif; other site 1117943000088 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1117943000089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943000090 active site 1117943000091 phosphorylation site [posttranslational modification] 1117943000092 intermolecular recognition site; other site 1117943000093 dimerization interface [polypeptide binding]; other site 1117943000094 Putative hemolysin [General function prediction only]; Region: COG3176 1117943000095 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1117943000096 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1117943000097 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1117943000098 putative NAD(P) binding site [chemical binding]; other site 1117943000099 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1117943000100 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1117943000101 MutS domain I; Region: MutS_I; pfam01624 1117943000102 MutS domain II; Region: MutS_II; pfam05188 1117943000103 MutS domain III; Region: MutS_III; pfam05192 1117943000104 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1117943000105 Walker A/P-loop; other site 1117943000106 ATP binding site [chemical binding]; other site 1117943000107 Q-loop/lid; other site 1117943000108 ABC transporter signature motif; other site 1117943000109 Walker B; other site 1117943000110 D-loop; other site 1117943000111 H-loop/switch region; other site 1117943000112 PII uridylyl-transferase; Provisional; Region: PRK05092 1117943000113 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1117943000114 metal binding triad; other site 1117943000115 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1117943000116 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1117943000117 Zn2+ binding site [ion binding]; other site 1117943000118 Mg2+ binding site [ion binding]; other site 1117943000119 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1117943000120 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1117943000121 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1117943000122 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1117943000123 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943000124 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1117943000125 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1117943000126 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1117943000127 active site 1117943000128 HIGH motif; other site 1117943000129 dimer interface [polypeptide binding]; other site 1117943000130 KMSKS motif; other site 1117943000131 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1117943000132 Ligand Binding Site [chemical binding]; other site 1117943000133 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 1117943000134 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1117943000135 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1117943000136 Glycoprotease family; Region: Peptidase_M22; pfam00814 1117943000137 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1117943000138 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943000139 Coenzyme A binding pocket [chemical binding]; other site 1117943000140 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1117943000141 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1117943000142 putative acyl-acceptor binding pocket; other site 1117943000143 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1117943000144 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1117943000145 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1117943000146 FeS/SAM binding site; other site 1117943000147 TRAM domain; Region: TRAM; pfam01938 1117943000148 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1117943000149 PhoH-like protein; Region: PhoH; pfam02562 1117943000150 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 1117943000151 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1117943000152 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1117943000153 Transporter associated domain; Region: CorC_HlyC; smart01091 1117943000154 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1117943000155 LabA_like proteins; Region: LabA; cd10911 1117943000156 putative metal binding site [ion binding]; other site 1117943000157 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1117943000158 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1117943000159 putative active site [active] 1117943000160 catalytic triad [active] 1117943000161 putative dimer interface [polypeptide binding]; other site 1117943000162 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943000163 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943000164 non-specific DNA binding site [nucleotide binding]; other site 1117943000165 salt bridge; other site 1117943000166 sequence-specific DNA binding site [nucleotide binding]; other site 1117943000167 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1117943000168 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1117943000169 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1117943000170 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1117943000171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943000172 S-adenosylmethionine binding site [chemical binding]; other site 1117943000173 Uncharacterized small protein [Function unknown]; Region: COG5568 1117943000174 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1117943000175 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1117943000176 putative dimer interface [polypeptide binding]; other site 1117943000177 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1117943000178 active site 1117943000179 tetramer interface [polypeptide binding]; other site 1117943000180 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943000181 Cache domain; Region: Cache_1; pfam02743 1117943000182 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1117943000183 dimerization interface [polypeptide binding]; other site 1117943000184 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1117943000185 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1117943000186 dimer interface [polypeptide binding]; other site 1117943000187 putative CheW interface [polypeptide binding]; other site 1117943000188 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1117943000189 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1117943000190 substrate binding site [chemical binding]; other site 1117943000191 dimer interface [polypeptide binding]; other site 1117943000192 ATP binding site [chemical binding]; other site 1117943000193 RmuC family; Region: RmuC; pfam02646 1117943000194 Predicted flavoprotein [General function prediction only]; Region: COG0431 1117943000195 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1117943000196 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1117943000197 active site 1117943000198 catalytic residues [active] 1117943000199 metal binding site [ion binding]; metal-binding site 1117943000200 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1117943000201 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1117943000202 putative active site [active] 1117943000203 substrate binding site [chemical binding]; other site 1117943000204 putative cosubstrate binding site; other site 1117943000205 catalytic site [active] 1117943000206 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1117943000207 substrate binding site [chemical binding]; other site 1117943000208 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1117943000209 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1117943000210 dimerization interface 3.5A [polypeptide binding]; other site 1117943000211 active site 1117943000212 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1117943000213 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1117943000214 metal binding site [ion binding]; metal-binding site 1117943000215 dimer interface [polypeptide binding]; other site 1117943000216 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1117943000217 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1117943000218 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1117943000219 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943000220 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1117943000221 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943000222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943000223 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1117943000224 putative effector binding pocket; other site 1117943000225 putative dimerization interface [polypeptide binding]; other site 1117943000226 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1117943000227 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1117943000228 ATP binding site [chemical binding]; other site 1117943000229 Mg++ binding site [ion binding]; other site 1117943000230 motif III; other site 1117943000231 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1117943000232 nucleotide binding region [chemical binding]; other site 1117943000233 ATP-binding site [chemical binding]; other site 1117943000234 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 1117943000235 RNA binding site [nucleotide binding]; other site 1117943000236 Predicted membrane protein [Function unknown]; Region: COG3152 1117943000237 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1117943000238 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1117943000239 trimer interface [polypeptide binding]; other site 1117943000240 active site 1117943000241 substrate binding site [chemical binding]; other site 1117943000242 CoA binding site [chemical binding]; other site 1117943000243 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1117943000244 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 1117943000245 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1117943000246 motif II; other site 1117943000247 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1117943000248 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1117943000249 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1117943000250 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1117943000251 DNA binding site [nucleotide binding] 1117943000252 active site 1117943000253 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1117943000254 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1117943000255 tetramer interface [polypeptide binding]; other site 1117943000256 active site 1117943000257 Mg2+/Mn2+ binding site [ion binding]; other site 1117943000258 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1117943000259 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1117943000260 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943000261 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1117943000262 homohexameric interface [polypeptide binding]; other site 1117943000263 feedback inhibition sensing region; other site 1117943000264 carbamate kinase; Reviewed; Region: PRK12686 1117943000265 nucleotide binding site [chemical binding]; other site 1117943000266 N-acetyl-L-glutamate binding site [chemical binding]; other site 1117943000267 RNA polymerase sigma factor; Provisional; Region: PRK12514 1117943000268 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1117943000269 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1117943000270 DNA binding residues [nucleotide binding] 1117943000271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 1117943000272 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1117943000273 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1117943000274 Fasciclin domain; Region: Fasciclin; pfam02469 1117943000275 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1117943000276 SelR domain; Region: SelR; pfam01641 1117943000277 Predicted membrane protein [Function unknown]; Region: COG4803 1117943000278 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1117943000279 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 1117943000280 G1 box; other site 1117943000281 GTP/Mg2+ binding site [chemical binding]; other site 1117943000282 Switch I region; other site 1117943000283 G2 box; other site 1117943000284 G3 box; other site 1117943000285 Switch II region; other site 1117943000286 G4 box; other site 1117943000287 G5 box; other site 1117943000288 membrane protein insertase; Provisional; Region: PRK01318 1117943000289 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1117943000290 ribonuclease P; Reviewed; Region: rnpA; PRK01313 1117943000291 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1117943000292 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1117943000293 dimerization interface [polypeptide binding]; other site 1117943000294 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1117943000295 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1117943000296 dimer interface [polypeptide binding]; other site 1117943000297 putative CheW interface [polypeptide binding]; other site 1117943000298 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1117943000299 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1117943000300 mercuric reductase; Validated; Region: PRK06370 1117943000301 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1117943000302 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1117943000303 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1117943000304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943000305 HAMP domain; Region: HAMP; pfam00672 1117943000306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943000307 ATP binding site [chemical binding]; other site 1117943000308 Mg2+ binding site [ion binding]; other site 1117943000309 G-X-G motif; other site 1117943000310 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1117943000311 putative deacylase active site [active] 1117943000312 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1117943000313 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 1117943000314 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1117943000315 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1117943000316 active site 1117943000317 catalytic tetrad [active] 1117943000318 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1117943000319 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1117943000320 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1117943000321 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 1117943000322 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1117943000323 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1117943000324 Glutamate binding site [chemical binding]; other site 1117943000325 NAD binding site [chemical binding]; other site 1117943000326 catalytic residues [active] 1117943000327 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1117943000328 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1117943000329 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1117943000330 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1117943000331 active site 1117943000332 metal binding site [ion binding]; metal-binding site 1117943000333 hexamer interface [polypeptide binding]; other site 1117943000334 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 1117943000335 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1117943000336 FecR protein; Region: FecR; pfam04773 1117943000337 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1117943000338 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 1117943000339 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943000340 cyclase homology domain; Region: CHD; cd07302 1117943000341 nucleotidyl binding site; other site 1117943000342 metal binding site [ion binding]; metal-binding site 1117943000343 dimer interface [polypeptide binding]; other site 1117943000344 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1117943000345 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1117943000346 ligand binding site [chemical binding]; other site 1117943000347 flexible hinge region; other site 1117943000348 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1117943000349 Predicted membrane protein [Function unknown]; Region: COG2259 1117943000350 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 1117943000351 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1117943000352 non-specific DNA interactions [nucleotide binding]; other site 1117943000353 DNA binding site [nucleotide binding] 1117943000354 sequence specific DNA binding site [nucleotide binding]; other site 1117943000355 putative cAMP binding site [chemical binding]; other site 1117943000356 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1117943000357 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1117943000358 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1117943000359 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1117943000360 ligand binding site [chemical binding]; other site 1117943000361 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943000362 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943000363 TM-ABC transporter signature motif; other site 1117943000364 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1117943000365 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1117943000366 active site 1117943000367 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1117943000368 active site 1117943000369 substrate binding pocket [chemical binding]; other site 1117943000370 dimer interface [polypeptide binding]; other site 1117943000371 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1117943000372 active site 1117943000373 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1117943000374 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1117943000375 putative substrate binding site [chemical binding]; other site 1117943000376 putative ATP binding site [chemical binding]; other site 1117943000377 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1117943000378 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1117943000379 active site 1117943000380 dimer interface [polypeptide binding]; other site 1117943000381 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1117943000382 dimer interface [polypeptide binding]; other site 1117943000383 active site 1117943000384 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 1117943000385 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1117943000386 acyl-activating enzyme (AAE) consensus motif; other site 1117943000387 putative AMP binding site [chemical binding]; other site 1117943000388 putative active site [active] 1117943000389 putative CoA binding site [chemical binding]; other site 1117943000390 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1117943000391 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1117943000392 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1117943000393 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1117943000394 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1117943000395 Ligand Binding Site [chemical binding]; other site 1117943000396 GAF domain; Region: GAF_3; pfam13492 1117943000397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943000398 dimer interface [polypeptide binding]; other site 1117943000399 phosphorylation site [posttranslational modification] 1117943000400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943000401 ATP binding site [chemical binding]; other site 1117943000402 Mg2+ binding site [ion binding]; other site 1117943000403 G-X-G motif; other site 1117943000404 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1117943000405 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1117943000406 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1117943000407 putative acyl-acceptor binding pocket; other site 1117943000408 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 1117943000409 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1117943000410 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943000411 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943000412 non-specific DNA binding site [nucleotide binding]; other site 1117943000413 salt bridge; other site 1117943000414 sequence-specific DNA binding site [nucleotide binding]; other site 1117943000415 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1117943000416 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1117943000417 active site 1117943000418 Int/Topo IB signature motif; other site 1117943000419 Helix-turn-helix domain; Region: HTH_17; cl17695 1117943000420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1117943000421 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1117943000422 Toprim domain; Region: Toprim_3; pfam13362 1117943000423 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1117943000424 RNA/DNA hybrid binding site [nucleotide binding]; other site 1117943000425 active site 1117943000426 transcriptional activator RfaH; Region: RfaH; TIGR01955 1117943000427 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 1117943000428 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1117943000429 heterodimer interface [polypeptide binding]; other site 1117943000430 homodimer interface [polypeptide binding]; other site 1117943000431 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 1117943000432 Protein of unknown function (DUF497); Region: DUF497; cl01108 1117943000433 Terminase-like family; Region: Terminase_6; pfam03237 1117943000434 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 1117943000435 DivIVA protein; Region: DivIVA; pfam05103 1117943000436 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1117943000437 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1117943000438 amidase catalytic site [active] 1117943000439 Zn binding residues [ion binding]; other site 1117943000440 substrate binding site [chemical binding]; other site 1117943000441 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1117943000442 DNA methylase; Region: N6_N4_Mtase; cl17433 1117943000443 DNA methylase; Region: N6_N4_Mtase; pfam01555 1117943000444 DNA methylase; Region: N6_N4_Mtase; pfam01555 1117943000445 Restriction endonuclease; Region: Mrr_cat; pfam04471 1117943000446 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1117943000447 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1117943000448 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1117943000449 FMN binding site [chemical binding]; other site 1117943000450 substrate binding site [chemical binding]; other site 1117943000451 putative catalytic residue [active] 1117943000452 Uncharacterized conserved protein [Function unknown]; Region: COG2326 1117943000453 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1117943000454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943000455 dimer interface [polypeptide binding]; other site 1117943000456 phosphorylation site [posttranslational modification] 1117943000457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943000458 ATP binding site [chemical binding]; other site 1117943000459 Mg2+ binding site [ion binding]; other site 1117943000460 G-X-G motif; other site 1117943000461 PBP superfamily domain; Region: PBP_like_2; pfam12849 1117943000462 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 1117943000463 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1117943000464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943000465 dimer interface [polypeptide binding]; other site 1117943000466 conserved gate region; other site 1117943000467 putative PBP binding loops; other site 1117943000468 ABC-ATPase subunit interface; other site 1117943000469 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 1117943000470 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1117943000471 Walker A/P-loop; other site 1117943000472 ATP binding site [chemical binding]; other site 1117943000473 Q-loop/lid; other site 1117943000474 ABC transporter signature motif; other site 1117943000475 Walker B; other site 1117943000476 D-loop; other site 1117943000477 H-loop/switch region; other site 1117943000478 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1117943000479 PhoU domain; Region: PhoU; pfam01895 1117943000480 PhoU domain; Region: PhoU; pfam01895 1117943000481 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1117943000482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943000483 active site 1117943000484 phosphorylation site [posttranslational modification] 1117943000485 intermolecular recognition site; other site 1117943000486 dimerization interface [polypeptide binding]; other site 1117943000487 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943000488 DNA binding site [nucleotide binding] 1117943000489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352 1117943000490 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 1117943000491 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1117943000492 inhibitor-cofactor binding pocket; inhibition site 1117943000493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943000494 catalytic residue [active] 1117943000495 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1117943000496 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1117943000497 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1117943000498 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1117943000499 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1117943000500 dimerization interface [polypeptide binding]; other site 1117943000501 domain crossover interface; other site 1117943000502 redox-dependent activation switch; other site 1117943000503 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1117943000504 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1117943000505 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 1117943000506 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1117943000507 homodimer interface [polypeptide binding]; other site 1117943000508 substrate-cofactor binding pocket; other site 1117943000509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943000510 catalytic residue [active] 1117943000511 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 1117943000512 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 1117943000513 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1117943000514 trimer interface [polypeptide binding]; other site 1117943000515 active site 1117943000516 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 1117943000517 trimer interface [polypeptide binding]; other site 1117943000518 active site 1117943000519 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943000520 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1117943000521 substrate binding pocket [chemical binding]; other site 1117943000522 membrane-bound complex binding site; other site 1117943000523 hinge residues; other site 1117943000524 tellurite resistance protein terB; Region: terB; cd07176 1117943000525 putative metal binding site [ion binding]; other site 1117943000526 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 1117943000527 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1117943000528 Predicted transcriptional regulator [Transcription]; Region: COG2932 1117943000529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1117943000530 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1117943000531 Catalytic site [active] 1117943000532 Predicted transcriptional regulators [Transcription]; Region: COG1733 1117943000533 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1117943000534 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 1117943000535 putative hydrophobic ligand binding site [chemical binding]; other site 1117943000536 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1117943000537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943000538 Coenzyme A binding pocket [chemical binding]; other site 1117943000539 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1117943000540 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1117943000541 substrate binding site [chemical binding]; other site 1117943000542 oxyanion hole (OAH) forming residues; other site 1117943000543 trimer interface [polypeptide binding]; other site 1117943000544 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1117943000545 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1117943000546 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1117943000547 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1117943000548 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1117943000549 dimer interface [polypeptide binding]; other site 1117943000550 active site 1117943000551 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1117943000552 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1117943000553 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1117943000554 FAD binding site [chemical binding]; other site 1117943000555 substrate binding site [chemical binding]; other site 1117943000556 catalytic residues [active] 1117943000557 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1117943000558 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1117943000559 Sel1-like repeats; Region: SEL1; smart00671 1117943000560 Sel1-like repeats; Region: SEL1; smart00671 1117943000561 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1117943000562 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1117943000563 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1117943000564 conserved hypothetical protein; Region: alph_Pro_TM; TIGR02186 1117943000565 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943000566 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943000567 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1117943000568 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 1117943000569 putative active site [active] 1117943000570 putative metal binding site [ion binding]; other site 1117943000571 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 1117943000572 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1117943000573 ATP binding site [chemical binding]; other site 1117943000574 putative Mg++ binding site [ion binding]; other site 1117943000575 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1117943000576 nucleotide binding region [chemical binding]; other site 1117943000577 ATP-binding site [chemical binding]; other site 1117943000578 DEAD/H associated; Region: DEAD_assoc; pfam08494 1117943000579 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1117943000580 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1117943000581 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943000582 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1117943000583 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1117943000584 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 1117943000585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943000586 TPR motif; other site 1117943000587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943000588 S-adenosylmethionine binding site [chemical binding]; other site 1117943000589 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1117943000590 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1117943000591 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1117943000592 putative efflux protein, MATE family; Region: matE; TIGR00797 1117943000593 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1117943000594 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1117943000595 quinone interaction residues [chemical binding]; other site 1117943000596 active site 1117943000597 catalytic residues [active] 1117943000598 FMN binding site [chemical binding]; other site 1117943000599 substrate binding site [chemical binding]; other site 1117943000600 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1117943000601 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1117943000602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943000603 active site 1117943000604 phosphorylation site [posttranslational modification] 1117943000605 intermolecular recognition site; other site 1117943000606 dimerization interface [polypeptide binding]; other site 1117943000607 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943000608 DNA binding residues [nucleotide binding] 1117943000609 dimerization interface [polypeptide binding]; other site 1117943000610 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1117943000611 Na binding site [ion binding]; other site 1117943000612 PAS fold; Region: PAS_7; pfam12860 1117943000613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943000614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943000615 dimer interface [polypeptide binding]; other site 1117943000616 phosphorylation site [posttranslational modification] 1117943000617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943000618 ATP binding site [chemical binding]; other site 1117943000619 Mg2+ binding site [ion binding]; other site 1117943000620 G-X-G motif; other site 1117943000621 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1117943000622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943000623 active site 1117943000624 phosphorylation site [posttranslational modification] 1117943000625 intermolecular recognition site; other site 1117943000626 dimerization interface [polypeptide binding]; other site 1117943000627 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1117943000628 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1117943000629 aspartate aminotransferase; Provisional; Region: PRK06108 1117943000630 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943000631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943000632 homodimer interface [polypeptide binding]; other site 1117943000633 catalytic residue [active] 1117943000634 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1117943000635 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1117943000636 NAD binding site [chemical binding]; other site 1117943000637 homodimer interface [polypeptide binding]; other site 1117943000638 active site 1117943000639 substrate binding site [chemical binding]; other site 1117943000640 Chorismate mutase type II; Region: CM_2; cl00693 1117943000641 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1117943000642 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1117943000643 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1117943000644 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1117943000645 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1117943000646 metal binding site [ion binding]; metal-binding site 1117943000647 putative dimer interface [polypeptide binding]; other site 1117943000648 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1117943000649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943000650 dimer interface [polypeptide binding]; other site 1117943000651 conserved gate region; other site 1117943000652 putative PBP binding loops; other site 1117943000653 ABC-ATPase subunit interface; other site 1117943000654 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1117943000655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943000656 Walker A/P-loop; other site 1117943000657 ATP binding site [chemical binding]; other site 1117943000658 Q-loop/lid; other site 1117943000659 ABC transporter signature motif; other site 1117943000660 Walker B; other site 1117943000661 D-loop; other site 1117943000662 H-loop/switch region; other site 1117943000663 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1117943000664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943000665 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1117943000666 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1117943000667 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943000668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943000669 homodimer interface [polypeptide binding]; other site 1117943000670 catalytic residue [active] 1117943000671 hypothetical protein; Provisional; Region: PRK07524 1117943000672 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1117943000673 PYR/PP interface [polypeptide binding]; other site 1117943000674 dimer interface [polypeptide binding]; other site 1117943000675 TPP binding site [chemical binding]; other site 1117943000676 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1117943000677 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1117943000678 TPP-binding site [chemical binding]; other site 1117943000679 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1117943000680 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1117943000681 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1117943000682 Protein export membrane protein; Region: SecD_SecF; pfam02355 1117943000683 KpsF/GutQ family protein; Region: kpsF; TIGR00393 1117943000684 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1117943000685 putative active site [active] 1117943000686 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1117943000687 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 1117943000688 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1117943000689 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1117943000690 Sulfatase; Region: Sulfatase; cl17466 1117943000691 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 1117943000692 putative NAD(P) binding site [chemical binding]; other site 1117943000693 homotetramer interface [polypeptide binding]; other site 1117943000694 active site 1117943000695 homodimer interface [polypeptide binding]; other site 1117943000696 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1117943000697 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1117943000698 substrate-cofactor binding pocket; other site 1117943000699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943000700 catalytic residue [active] 1117943000701 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1117943000702 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1117943000703 active site 1117943000704 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1117943000705 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1117943000706 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1117943000707 Enoylreductase; Region: PKS_ER; smart00829 1117943000708 NAD(P) binding site [chemical binding]; other site 1117943000709 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1117943000710 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1117943000711 NADP binding site [chemical binding]; other site 1117943000712 active site 1117943000713 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1117943000714 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1117943000715 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1117943000716 SLBB domain; Region: SLBB; pfam10531 1117943000717 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1117943000718 Isochorismatase family; Region: Isochorismatase; pfam00857 1117943000719 catalytic triad [active] 1117943000720 metal binding site [ion binding]; metal-binding site 1117943000721 conserved cis-peptide bond; other site 1117943000722 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 1117943000723 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 1117943000724 active site 1117943000725 Transglycosylase; Region: Transgly; pfam00912 1117943000726 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1117943000727 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1117943000728 BA14K-like protein; Region: BA14K; pfam07886 1117943000729 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1117943000730 Peptidase family M50; Region: Peptidase_M50; pfam02163 1117943000731 active site 1117943000732 putative substrate binding region [chemical binding]; other site 1117943000733 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943000734 active site 1117943000735 DNA binding site [nucleotide binding] 1117943000736 Int/Topo IB signature motif; other site 1117943000737 T5orf172 domain; Region: T5orf172; cl17462 1117943000738 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1117943000739 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1117943000740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943000741 Walker A motif; other site 1117943000742 ATP binding site [chemical binding]; other site 1117943000743 Walker B motif; other site 1117943000744 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1117943000745 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943000746 Integrase core domain; Region: rve; pfam00665 1117943000747 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943000748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943000749 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943000750 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943000751 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943000752 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943000753 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943000754 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 1117943000755 DNA binding site [nucleotide binding] 1117943000756 dimer interface [polypeptide binding]; other site 1117943000757 active site 1117943000758 Int/Topo IB signature motif; other site 1117943000759 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1117943000760 integron integrase; Region: integrase_gron; TIGR02249 1117943000761 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943000762 active site 1117943000763 Int/Topo IB signature motif; other site 1117943000764 DNA binding site [nucleotide binding] 1117943000765 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 1117943000766 Putative transposase; Region: Y2_Tnp; pfam04986 1117943000767 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1117943000768 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1117943000769 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1117943000770 hinge; other site 1117943000771 active site 1117943000772 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 1117943000773 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1117943000774 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1117943000775 NAD binding site [chemical binding]; other site 1117943000776 dimerization interface [polypeptide binding]; other site 1117943000777 product binding site; other site 1117943000778 substrate binding site [chemical binding]; other site 1117943000779 zinc binding site [ion binding]; other site 1117943000780 catalytic residues [active] 1117943000781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5328 1117943000782 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1117943000783 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1117943000784 active site 1117943000785 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1117943000786 rRNA binding site [nucleotide binding]; other site 1117943000787 predicted 30S ribosome binding site; other site 1117943000788 Maf-like protein; Region: Maf; pfam02545 1117943000789 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1117943000790 active site 1117943000791 dimer interface [polypeptide binding]; other site 1117943000792 zinc-binding protein; Provisional; Region: PRK01343 1117943000793 RibD C-terminal domain; Region: RibD_C; cl17279 1117943000794 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1117943000795 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1117943000796 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943000797 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943000798 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943000799 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1117943000800 substrate binding pocket [chemical binding]; other site 1117943000801 dimerization interface [polypeptide binding]; other site 1117943000802 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1117943000803 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1117943000804 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1117943000805 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1117943000806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943000807 binding surface 1117943000808 TPR motif; other site 1117943000809 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1117943000810 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1117943000811 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1117943000812 UDP-galactopyranose mutase; Region: GLF; pfam03275 1117943000813 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1117943000814 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1117943000815 conserved cys residue [active] 1117943000816 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943000817 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943000818 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1117943000819 putative deacylase active site [active] 1117943000820 Predicted membrane protein [Function unknown]; Region: COG2261 1117943000821 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952 1117943000822 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 1117943000823 short chain dehydrogenase; Validated; Region: PRK08324 1117943000824 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1117943000825 active site 1117943000826 Zn2+ binding site [ion binding]; other site 1117943000827 intersubunit interface [polypeptide binding]; other site 1117943000828 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 1117943000829 putative NAD(P) binding site [chemical binding]; other site 1117943000830 active site 1117943000831 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1117943000832 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1117943000833 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1117943000834 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1117943000835 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 1117943000836 ligand binding site [chemical binding]; other site 1117943000837 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1117943000838 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1117943000839 Walker A/P-loop; other site 1117943000840 ATP binding site [chemical binding]; other site 1117943000841 Q-loop/lid; other site 1117943000842 ABC transporter signature motif; other site 1117943000843 Walker B; other site 1117943000844 D-loop; other site 1117943000845 H-loop/switch region; other site 1117943000846 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1117943000847 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943000848 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943000849 TM-ABC transporter signature motif; other site 1117943000850 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943000851 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943000852 TM-ABC transporter signature motif; other site 1117943000853 Uncharacterized conserved protein [Function unknown]; Region: COG3254 1117943000854 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1117943000855 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 1117943000856 N- and C-terminal domain interface [polypeptide binding]; other site 1117943000857 putative active site [active] 1117943000858 putative MgATP binding site [chemical binding]; other site 1117943000859 putative catalytic site [active] 1117943000860 metal binding site [ion binding]; metal-binding site 1117943000861 putative carbohydrate binding site [chemical binding]; other site 1117943000862 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1117943000863 heme-binding site [chemical binding]; other site 1117943000864 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1117943000865 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1117943000866 dimer interface [polypeptide binding]; other site 1117943000867 putative CheW interface [polypeptide binding]; other site 1117943000868 STAS domain; Region: STAS_2; pfam13466 1117943000869 Response regulator receiver domain; Region: Response_reg; pfam00072 1117943000870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943000871 active site 1117943000872 phosphorylation site [posttranslational modification] 1117943000873 intermolecular recognition site; other site 1117943000874 dimerization interface [polypeptide binding]; other site 1117943000875 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1117943000876 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1117943000877 putative binding surface; other site 1117943000878 active site 1117943000879 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1117943000880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943000881 ATP binding site [chemical binding]; other site 1117943000882 Mg2+ binding site [ion binding]; other site 1117943000883 G-X-G motif; other site 1117943000884 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1117943000885 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1117943000886 putative CheA interaction surface; other site 1117943000887 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1117943000888 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1117943000889 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1117943000890 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1117943000891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943000892 active site 1117943000893 phosphorylation site [posttranslational modification] 1117943000894 intermolecular recognition site; other site 1117943000895 dimerization interface [polypeptide binding]; other site 1117943000896 CheB methylesterase; Region: CheB_methylest; pfam01339 1117943000897 Response regulator receiver domain; Region: Response_reg; pfam00072 1117943000898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943000899 active site 1117943000900 phosphorylation site [posttranslational modification] 1117943000901 intermolecular recognition site; other site 1117943000902 dimerization interface [polypeptide binding]; other site 1117943000903 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13497 1117943000904 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1117943000905 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1117943000906 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1117943000907 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1117943000908 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943000909 DNA binding residues [nucleotide binding] 1117943000910 dimerization interface [polypeptide binding]; other site 1117943000911 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1117943000912 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943000913 DNA binding residues [nucleotide binding] 1117943000914 dimerization interface [polypeptide binding]; other site 1117943000915 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1117943000916 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1117943000917 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1117943000918 MgtE intracellular N domain; Region: MgtE_N; smart00924 1117943000919 FliG C-terminal domain; Region: FliG_C; pfam01706 1117943000920 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1117943000921 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 1117943000922 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1117943000923 NAD(P) binding site [chemical binding]; other site 1117943000924 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1117943000925 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1117943000926 flagellar motor protein MotA; Validated; Region: PRK09110 1117943000927 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1117943000928 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 1117943000929 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1117943000930 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1117943000931 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 1117943000932 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1117943000933 Walker A motif; other site 1117943000934 ATP binding site [chemical binding]; other site 1117943000935 Walker B motif; other site 1117943000936 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 1117943000937 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 1117943000938 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1117943000939 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1117943000940 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 1117943000941 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 1117943000942 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1117943000943 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 1117943000944 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1117943000945 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1117943000946 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1117943000947 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1117943000948 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1117943000949 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1117943000950 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1117943000951 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1117943000952 flagellin; Reviewed; Region: PRK12687 1117943000953 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1117943000954 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1117943000955 flagellin; Reviewed; Region: PRK12687 1117943000956 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1117943000957 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1117943000958 flagellin; Reviewed; Region: PRK12687 1117943000959 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1117943000960 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1117943000961 flagellin; Reviewed; Region: PRK12687 1117943000962 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1117943000963 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1117943000964 flagellar motor protein MotB; Validated; Region: motB; PRK05996 1117943000965 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1117943000966 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1117943000967 ligand binding site [chemical binding]; other site 1117943000968 chemotaxis protein; Reviewed; Region: PRK12798 1117943000969 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1117943000970 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1117943000971 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1117943000972 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1117943000973 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1117943000974 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943000975 DNA binding site [nucleotide binding] 1117943000976 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1117943000977 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1117943000978 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1117943000979 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1117943000980 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 1117943000981 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 1117943000982 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1117943000983 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1117943000984 Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442 1117943000985 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 1117943000986 Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443 1117943000987 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 1117943000988 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1117943000989 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 1117943000990 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1117943000991 FHIPEP family; Region: FHIPEP; pfam00771 1117943000992 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1117943000993 Rod binding protein; Region: Rod-binding; pfam10135 1117943000994 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1117943000995 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1117943000996 active site 1117943000997 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 1117943000998 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1117943000999 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1117943001000 homodimer interface [polypeptide binding]; other site 1117943001001 NADP binding site [chemical binding]; other site 1117943001002 substrate binding site [chemical binding]; other site 1117943001003 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1117943001004 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943001005 DNA binding site [nucleotide binding] 1117943001006 domain linker motif; other site 1117943001007 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1117943001008 ligand binding site [chemical binding]; other site 1117943001009 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943001010 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943001011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943001012 dimer interface [polypeptide binding]; other site 1117943001013 conserved gate region; other site 1117943001014 putative PBP binding loops; other site 1117943001015 ABC-ATPase subunit interface; other site 1117943001016 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943001017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943001018 dimer interface [polypeptide binding]; other site 1117943001019 conserved gate region; other site 1117943001020 putative PBP binding loops; other site 1117943001021 ABC-ATPase subunit interface; other site 1117943001022 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 1117943001023 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1117943001024 active site 1117943001025 catalytic site [active] 1117943001026 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1117943001027 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943001028 Walker A/P-loop; other site 1117943001029 ATP binding site [chemical binding]; other site 1117943001030 Q-loop/lid; other site 1117943001031 ABC transporter signature motif; other site 1117943001032 Walker B; other site 1117943001033 D-loop; other site 1117943001034 H-loop/switch region; other site 1117943001035 TOBE domain; Region: TOBE_2; pfam08402 1117943001036 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 1117943001037 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1117943001038 phosphogluconate dehydratase; Validated; Region: PRK09054 1117943001039 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1117943001040 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1117943001041 putative active site [active] 1117943001042 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1117943001043 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1117943001044 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1117943001045 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1117943001046 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943001047 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1117943001048 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1117943001049 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1117943001050 Predicted flavoproteins [General function prediction only]; Region: COG2081 1117943001051 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1117943001052 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943001053 dimerization interface [polypeptide binding]; other site 1117943001054 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1117943001055 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1117943001056 dimer interface [polypeptide binding]; other site 1117943001057 putative CheW interface [polypeptide binding]; other site 1117943001058 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943001059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943001060 Paired amphipathic helix repeat; Region: PAH; pfam02671 1117943001061 isocitrate lyase; Provisional; Region: PRK15063 1117943001062 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943001063 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943001064 non-specific DNA binding site [nucleotide binding]; other site 1117943001065 salt bridge; other site 1117943001066 sequence-specific DNA binding site [nucleotide binding]; other site 1117943001067 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1117943001068 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1117943001069 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1117943001070 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 1117943001071 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1117943001072 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1117943001073 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1117943001074 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1117943001075 Walker A/P-loop; other site 1117943001076 ATP binding site [chemical binding]; other site 1117943001077 Q-loop/lid; other site 1117943001078 ABC transporter signature motif; other site 1117943001079 Walker B; other site 1117943001080 D-loop; other site 1117943001081 H-loop/switch region; other site 1117943001082 TOBE domain; Region: TOBE_2; pfam08402 1117943001083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943001084 dimer interface [polypeptide binding]; other site 1117943001085 conserved gate region; other site 1117943001086 putative PBP binding loops; other site 1117943001087 ABC-ATPase subunit interface; other site 1117943001088 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1117943001089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943001090 dimer interface [polypeptide binding]; other site 1117943001091 conserved gate region; other site 1117943001092 putative PBP binding loops; other site 1117943001093 ABC-ATPase subunit interface; other site 1117943001094 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1117943001095 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1117943001096 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1117943001097 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 1117943001098 acyl-activating enzyme (AAE) consensus motif; other site 1117943001099 putative AMP binding site [chemical binding]; other site 1117943001100 putative active site [active] 1117943001101 putative CoA binding site [chemical binding]; other site 1117943001102 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1117943001103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1117943001104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943001105 putative PBP binding loops; other site 1117943001106 dimer interface [polypeptide binding]; other site 1117943001107 ABC-ATPase subunit interface; other site 1117943001108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943001109 dimer interface [polypeptide binding]; other site 1117943001110 conserved gate region; other site 1117943001111 putative PBP binding loops; other site 1117943001112 ABC-ATPase subunit interface; other site 1117943001113 PAS domain; Region: PAS_8; pfam13188 1117943001114 PAS domain S-box; Region: sensory_box; TIGR00229 1117943001115 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943001116 putative active site [active] 1117943001117 heme pocket [chemical binding]; other site 1117943001118 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943001119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943001120 dimer interface [polypeptide binding]; other site 1117943001121 phosphorylation site [posttranslational modification] 1117943001122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943001123 ATP binding site [chemical binding]; other site 1117943001124 Mg2+ binding site [ion binding]; other site 1117943001125 G-X-G motif; other site 1117943001126 Phasin protein; Region: Phasin_2; cl11491 1117943001127 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943001128 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943001129 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943001130 dimerization interface [polypeptide binding]; other site 1117943001131 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1117943001132 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1117943001133 tetrameric interface [polypeptide binding]; other site 1117943001134 NAD binding site [chemical binding]; other site 1117943001135 catalytic residues [active] 1117943001136 Predicted membrane protein [Function unknown]; Region: COG4269 1117943001137 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1117943001138 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1117943001139 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1117943001140 iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920 1117943001141 Rrf2 family protein; Region: rrf2_super; TIGR00738 1117943001142 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1117943001143 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1117943001144 peptide binding site [polypeptide binding]; other site 1117943001145 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1117943001146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943001147 dimer interface [polypeptide binding]; other site 1117943001148 conserved gate region; other site 1117943001149 putative PBP binding loops; other site 1117943001150 ABC-ATPase subunit interface; other site 1117943001151 dipeptide transporter; Provisional; Region: PRK10913 1117943001152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943001153 dimer interface [polypeptide binding]; other site 1117943001154 conserved gate region; other site 1117943001155 putative PBP binding loops; other site 1117943001156 ABC-ATPase subunit interface; other site 1117943001157 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1117943001158 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943001159 Walker A/P-loop; other site 1117943001160 ATP binding site [chemical binding]; other site 1117943001161 Q-loop/lid; other site 1117943001162 ABC transporter signature motif; other site 1117943001163 Walker B; other site 1117943001164 D-loop; other site 1117943001165 H-loop/switch region; other site 1117943001166 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1117943001167 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943001168 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1117943001169 Walker A/P-loop; other site 1117943001170 ATP binding site [chemical binding]; other site 1117943001171 Q-loop/lid; other site 1117943001172 ABC transporter signature motif; other site 1117943001173 Walker B; other site 1117943001174 D-loop; other site 1117943001175 H-loop/switch region; other site 1117943001176 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1117943001177 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1117943001178 homotrimer interaction site [polypeptide binding]; other site 1117943001179 putative active site [active] 1117943001180 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1117943001181 two-component response regulator; Provisional; Region: PRK09191 1117943001182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943001183 active site 1117943001184 phosphorylation site [posttranslational modification] 1117943001185 intermolecular recognition site; other site 1117943001186 dimerization interface [polypeptide binding]; other site 1117943001187 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1117943001188 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 1117943001189 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943001190 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1117943001191 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1117943001192 MgtC family; Region: MgtC; pfam02308 1117943001193 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 1117943001194 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1117943001195 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1117943001196 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1117943001197 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1117943001198 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1117943001199 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1117943001200 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943001201 cyclase homology domain; Region: CHD; cd07302 1117943001202 nucleotidyl binding site; other site 1117943001203 metal binding site [ion binding]; metal-binding site 1117943001204 dimer interface [polypeptide binding]; other site 1117943001205 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943001206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943001207 TPR motif; other site 1117943001208 binding surface 1117943001209 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1117943001210 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943001211 binding surface 1117943001212 TPR motif; other site 1117943001213 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1117943001214 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943001215 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1117943001216 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1117943001217 active site 1117943001218 catalytic residues [active] 1117943001219 DNA binding site [nucleotide binding] 1117943001220 Int/Topo IB signature motif; other site 1117943001221 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 1117943001222 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1117943001223 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1117943001224 catalytic residues [active] 1117943001225 catalytic nucleophile [active] 1117943001226 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 1117943001227 DNA-binding interface [nucleotide binding]; DNA binding site 1117943001228 Prophage antirepressor [Transcription]; Region: COG3617 1117943001229 BRO family, N-terminal domain; Region: Bro-N; smart01040 1117943001230 ParB-like nuclease domain; Region: ParB; smart00470 1117943001231 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 1117943001232 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943001233 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1117943001234 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943001235 active site 1117943001236 DNA binding site [nucleotide binding] 1117943001237 Int/Topo IB signature motif; other site 1117943001238 Arc-like DNA binding domain; Region: Arc; pfam03869 1117943001239 Helix-turn-helix domain; Region: HTH_17; cl17695 1117943001240 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1117943001241 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1117943001242 catalytic residues [active] 1117943001243 catalytic nucleophile [active] 1117943001244 Recombinase; Region: Recombinase; pfam07508 1117943001245 Terminase-like family; Region: Terminase_6; pfam03237 1117943001246 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1117943001247 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1117943001248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943001249 Integrase core domain; Region: rve; pfam00665 1117943001250 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943001251 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1117943001252 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1117943001253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943001254 Walker A motif; other site 1117943001255 ATP binding site [chemical binding]; other site 1117943001256 Walker B motif; other site 1117943001257 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 1117943001258 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943001259 non-specific DNA binding site [nucleotide binding]; other site 1117943001260 salt bridge; other site 1117943001261 sequence-specific DNA binding site [nucleotide binding]; other site 1117943001262 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1117943001263 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1117943001264 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1117943001265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943001266 S-adenosylmethionine binding site [chemical binding]; other site 1117943001267 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1117943001268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943001269 putative substrate translocation pore; other site 1117943001270 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1117943001271 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1117943001272 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1117943001273 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1117943001274 active site 1117943001275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5331 1117943001276 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1117943001277 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1117943001278 NAD binding site [chemical binding]; other site 1117943001279 substrate binding site [chemical binding]; other site 1117943001280 catalytic Zn binding site [ion binding]; other site 1117943001281 tetramer interface [polypeptide binding]; other site 1117943001282 structural Zn binding site [ion binding]; other site 1117943001283 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1117943001284 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1117943001285 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943001286 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1117943001287 dimerization interface [polypeptide binding]; other site 1117943001288 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943001289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943001290 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943001291 dimerization interface [polypeptide binding]; other site 1117943001292 Uncharacterized conserved protein [Function unknown]; Region: COG5403 1117943001293 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 1117943001294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1117943001295 Phosphate transporter family; Region: PHO4; pfam01384 1117943001296 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1117943001297 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 1117943001298 nudix motif; other site 1117943001299 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 1117943001300 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943001301 DNA-binding site [nucleotide binding]; DNA binding site 1117943001302 FCD domain; Region: FCD; pfam07729 1117943001303 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4949 1117943001304 transcriptional activator TtdR; Provisional; Region: PRK09801 1117943001305 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1117943001306 putative effector binding pocket; other site 1117943001307 dimerization interface [polypeptide binding]; other site 1117943001308 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1117943001309 FAD binding domain; Region: FAD_binding_4; pfam01565 1117943001310 FAD binding domain; Region: FAD_binding_4; pfam01565 1117943001311 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1117943001312 Predicted membrane protein [Function unknown]; Region: COG3671 1117943001313 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1117943001314 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1117943001315 Cysteine-rich domain; Region: CCG; pfam02754 1117943001316 Cysteine-rich domain; Region: CCG; pfam02754 1117943001317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1117943001318 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1117943001319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1117943001320 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1117943001321 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1117943001322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 1117943001323 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 1117943001324 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1117943001325 dimer interface [polypeptide binding]; other site 1117943001326 motif 1; other site 1117943001327 motif 2; other site 1117943001328 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1117943001329 active site 1117943001330 motif 3; other site 1117943001331 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1117943001332 anticodon binding site; other site 1117943001333 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 1117943001334 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1117943001335 dimer interface [polypeptide binding]; other site 1117943001336 motif 1; other site 1117943001337 active site 1117943001338 motif 2; other site 1117943001339 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1117943001340 motif 3; other site 1117943001341 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1117943001342 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 1117943001343 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1117943001344 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1117943001345 C-terminal domain interface [polypeptide binding]; other site 1117943001346 GSH binding site (G-site) [chemical binding]; other site 1117943001347 dimer interface [polypeptide binding]; other site 1117943001348 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1117943001349 dimer interface [polypeptide binding]; other site 1117943001350 N-terminal domain interface [polypeptide binding]; other site 1117943001351 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1117943001352 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1117943001353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1117943001354 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1117943001355 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1117943001356 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1117943001357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943001358 PAS domain; Region: PAS_9; pfam13426 1117943001359 putative active site [active] 1117943001360 heme pocket [chemical binding]; other site 1117943001361 PAS fold; Region: PAS_7; pfam12860 1117943001362 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943001363 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943001364 metal binding site [ion binding]; metal-binding site 1117943001365 active site 1117943001366 I-site; other site 1117943001367 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1117943001368 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1117943001369 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1117943001370 ring oligomerisation interface [polypeptide binding]; other site 1117943001371 ATP/Mg binding site [chemical binding]; other site 1117943001372 stacking interactions; other site 1117943001373 hinge regions; other site 1117943001374 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1117943001375 oligomerisation interface [polypeptide binding]; other site 1117943001376 mobile loop; other site 1117943001377 roof hairpin; other site 1117943001378 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1117943001379 active site residue [active] 1117943001380 Uncharacterized conserved protein [Function unknown]; Region: COG4275 1117943001381 Chromate transporter; Region: Chromate_transp; cl17781 1117943001382 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1117943001383 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1117943001384 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1117943001385 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1117943001386 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1117943001387 active site 1117943001388 Riboflavin kinase; Region: Flavokinase; smart00904 1117943001389 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 1117943001390 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1117943001391 active site 1117943001392 HIGH motif; other site 1117943001393 nucleotide binding site [chemical binding]; other site 1117943001394 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1117943001395 active site 1117943001396 KMSKS motif; other site 1117943001397 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1117943001398 tRNA binding surface [nucleotide binding]; other site 1117943001399 anticodon binding site; other site 1117943001400 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943001401 Coenzyme A binding pocket [chemical binding]; other site 1117943001402 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1117943001403 nucleoside/Zn binding site; other site 1117943001404 dimer interface [polypeptide binding]; other site 1117943001405 catalytic motif [active] 1117943001406 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1117943001407 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1117943001408 RNA binding surface [nucleotide binding]; other site 1117943001409 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1117943001410 active site 1117943001411 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1117943001412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943001413 S-adenosylmethionine binding site [chemical binding]; other site 1117943001414 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1117943001415 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1117943001416 active site 1117943001417 nucleophile elbow; other site 1117943001418 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1117943001419 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1117943001420 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1117943001421 TrkA-N domain; Region: TrkA_N; pfam02254 1117943001422 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1117943001423 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1117943001424 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1117943001425 active site 1117943001426 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 1117943001427 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 1117943001428 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1117943001429 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1117943001430 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1117943001431 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1117943001432 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943001433 motif II; other site 1117943001434 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1117943001435 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1117943001436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 1117943001437 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1117943001438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943001439 ATP binding site [chemical binding]; other site 1117943001440 Mg2+ binding site [ion binding]; other site 1117943001441 G-X-G motif; other site 1117943001442 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1117943001443 ATP binding site [chemical binding]; other site 1117943001444 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1117943001445 PAS fold; Region: PAS_4; pfam08448 1117943001446 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943001447 putative active site [active] 1117943001448 heme pocket [chemical binding]; other site 1117943001449 Response regulator receiver domain; Region: Response_reg; pfam00072 1117943001450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943001451 active site 1117943001452 phosphorylation site [posttranslational modification] 1117943001453 intermolecular recognition site; other site 1117943001454 dimerization interface [polypeptide binding]; other site 1117943001455 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943001456 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943001457 metal binding site [ion binding]; metal-binding site 1117943001458 active site 1117943001459 I-site; other site 1117943001460 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1117943001461 PRC-barrel domain; Region: PRC; pfam05239 1117943001462 dihydroxy-acid dehydratase; Validated; Region: PRK06131 1117943001463 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1117943001464 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1117943001465 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1117943001466 active site 1117943001467 intersubunit interface [polypeptide binding]; other site 1117943001468 catalytic residue [active] 1117943001469 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1117943001470 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1117943001471 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1117943001472 classical (c) SDRs; Region: SDR_c; cd05233 1117943001473 NAD(P) binding site [chemical binding]; other site 1117943001474 active site 1117943001475 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1117943001476 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1117943001477 Bacterial transcriptional regulator; Region: IclR; pfam01614 1117943001478 transcriptional regulator TraR; Provisional; Region: PRK13870 1117943001479 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1117943001480 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943001481 DNA binding residues [nucleotide binding] 1117943001482 dimerization interface [polypeptide binding]; other site 1117943001483 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1117943001484 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943001485 DNA binding residues [nucleotide binding] 1117943001486 dimerization interface [polypeptide binding]; other site 1117943001487 Domain of unknown function DUF59; Region: DUF59; pfam01883 1117943001488 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1117943001489 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1117943001490 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1117943001491 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 1117943001492 Cl binding site [ion binding]; other site 1117943001493 oligomer interface [polypeptide binding]; other site 1117943001494 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1117943001495 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1117943001496 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1117943001497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 1117943001498 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1117943001499 ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Region: ATP_synt_6_or_A; TIGR01131 1117943001500 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 1117943001501 F0F1 ATP synthase subunit B'; Validated; Region: PRK09174 1117943001502 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1117943001503 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 1117943001504 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 1117943001505 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1117943001506 putative C-terminal domain interface [polypeptide binding]; other site 1117943001507 putative GSH binding site (G-site) [chemical binding]; other site 1117943001508 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1117943001509 putative dimer interface [polypeptide binding]; other site 1117943001510 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 1117943001511 N-terminal domain interface [polypeptide binding]; other site 1117943001512 putative substrate binding pocket (H-site) [chemical binding]; other site 1117943001513 dimer interface [polypeptide binding]; other site 1117943001514 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1117943001515 RNA/DNA hybrid binding site [nucleotide binding]; other site 1117943001516 active site 1117943001517 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1117943001518 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1117943001519 FeS/SAM binding site; other site 1117943001520 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1117943001521 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1117943001522 active site 1117943001523 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1117943001524 MPT binding site; other site 1117943001525 trimer interface [polypeptide binding]; other site 1117943001526 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 1117943001527 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1117943001528 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1117943001529 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943001530 binding surface 1117943001531 TPR motif; other site 1117943001532 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943001533 binding surface 1117943001534 TPR motif; other site 1117943001535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943001536 binding surface 1117943001537 TPR motif; other site 1117943001538 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1117943001539 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1117943001540 substrate binding pocket [chemical binding]; other site 1117943001541 chain length determination region; other site 1117943001542 substrate-Mg2+ binding site; other site 1117943001543 catalytic residues [active] 1117943001544 aspartate-rich region 1; other site 1117943001545 active site lid residues [active] 1117943001546 aspartate-rich region 2; other site 1117943001547 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1117943001548 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1117943001549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943001550 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1117943001551 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1117943001552 tandem repeat interface [polypeptide binding]; other site 1117943001553 oligomer interface [polypeptide binding]; other site 1117943001554 active site residues [active] 1117943001555 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1117943001556 dimer interface [polypeptide binding]; other site 1117943001557 motif 1; other site 1117943001558 active site 1117943001559 motif 2; other site 1117943001560 motif 3; other site 1117943001561 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1117943001562 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1117943001563 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1117943001564 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1117943001565 Helix-turn-helix domain; Region: HTH_18; pfam12833 1117943001566 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1117943001567 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1117943001568 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1117943001569 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1117943001570 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1117943001571 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1117943001572 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1117943001573 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943001574 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943001575 metal binding site [ion binding]; metal-binding site 1117943001576 active site 1117943001577 I-site; other site 1117943001578 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1117943001579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943001580 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1117943001581 putative substrate translocation pore; other site 1117943001582 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1117943001583 Helix-turn-helix domain; Region: HTH_18; pfam12833 1117943001584 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943001585 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 1117943001586 UbiA prenyltransferase family; Region: UbiA; pfam01040 1117943001587 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1117943001588 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1117943001589 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1117943001590 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1117943001591 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1117943001592 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1117943001593 FAD binding domain; Region: FAD_binding_4; pfam01565 1117943001594 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1117943001595 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1117943001596 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1117943001597 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1117943001598 [2Fe-2S] cluster binding site [ion binding]; other site 1117943001599 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1117943001600 putative alpha subunit interface [polypeptide binding]; other site 1117943001601 putative active site [active] 1117943001602 putative substrate binding site [chemical binding]; other site 1117943001603 Fe binding site [ion binding]; other site 1117943001604 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1117943001605 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1117943001606 FAD binding pocket [chemical binding]; other site 1117943001607 FAD binding motif [chemical binding]; other site 1117943001608 phosphate binding motif [ion binding]; other site 1117943001609 beta-alpha-beta structure motif; other site 1117943001610 NAD binding pocket [chemical binding]; other site 1117943001611 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1117943001612 catalytic loop [active] 1117943001613 iron binding site [ion binding]; other site 1117943001614 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1117943001615 active site 1117943001616 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1117943001617 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 1117943001618 Cl binding site [ion binding]; other site 1117943001619 oligomer interface [polypeptide binding]; other site 1117943001620 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1117943001621 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1117943001622 active site 1117943001623 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1117943001624 enoyl-CoA hydratase; Provisional; Region: PRK06688 1117943001625 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1117943001626 substrate binding site [chemical binding]; other site 1117943001627 oxyanion hole (OAH) forming residues; other site 1117943001628 trimer interface [polypeptide binding]; other site 1117943001629 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1117943001630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943001631 S-adenosylmethionine binding site [chemical binding]; other site 1117943001632 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1117943001633 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1117943001634 RNA binding surface [nucleotide binding]; other site 1117943001635 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1117943001636 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1117943001637 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1117943001638 TPP-binding site; other site 1117943001639 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1117943001640 PYR/PP interface [polypeptide binding]; other site 1117943001641 dimer interface [polypeptide binding]; other site 1117943001642 TPP binding site [chemical binding]; other site 1117943001643 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1117943001644 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1117943001645 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1117943001646 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1117943001647 putative active site [active] 1117943001648 Zn binding site [ion binding]; other site 1117943001649 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1117943001650 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 1117943001651 NADP binding site [chemical binding]; other site 1117943001652 dimer interface [polypeptide binding]; other site 1117943001653 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1117943001654 active site 1117943001655 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1117943001656 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1117943001657 dimer interface [polypeptide binding]; other site 1117943001658 active site 1117943001659 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1117943001660 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1117943001661 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1117943001662 acyl-activating enzyme (AAE) consensus motif; other site 1117943001663 AMP binding site [chemical binding]; other site 1117943001664 active site 1117943001665 acyl-activating enzyme (AAE) consensus motif; other site 1117943001666 CoA binding site [chemical binding]; other site 1117943001667 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1117943001668 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1117943001669 Walker A/P-loop; other site 1117943001670 ATP binding site [chemical binding]; other site 1117943001671 Q-loop/lid; other site 1117943001672 ABC transporter signature motif; other site 1117943001673 Walker B; other site 1117943001674 D-loop; other site 1117943001675 H-loop/switch region; other site 1117943001676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1117943001677 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1117943001678 protease TldD; Provisional; Region: tldD; PRK10735 1117943001679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943001680 Coenzyme A binding pocket [chemical binding]; other site 1117943001681 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1117943001682 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1117943001683 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1117943001684 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1117943001685 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 1117943001686 putative active site [active] 1117943001687 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1117943001688 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1117943001689 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1117943001690 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 1117943001691 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1117943001692 HSP70 interaction site [polypeptide binding]; other site 1117943001693 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1117943001694 substrate binding site [polypeptide binding]; other site 1117943001695 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1117943001696 dimer interface [polypeptide binding]; other site 1117943001697 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 1117943001698 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1117943001699 NAD binding site [chemical binding]; other site 1117943001700 homotetramer interface [polypeptide binding]; other site 1117943001701 homodimer interface [polypeptide binding]; other site 1117943001702 substrate binding site [chemical binding]; other site 1117943001703 active site 1117943001704 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1117943001705 catalytic core [active] 1117943001706 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 1117943001707 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1117943001708 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1117943001709 Tetramer interface [polypeptide binding]; other site 1117943001710 active site 1117943001711 FMN-binding site [chemical binding]; other site 1117943001712 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1117943001713 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1117943001714 dimerization interface [polypeptide binding]; other site 1117943001715 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 1117943001716 active site 1117943001717 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 1117943001718 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00051 1117943001719 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1117943001720 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1117943001721 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 1117943001722 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1117943001723 Subunit I/III interface [polypeptide binding]; other site 1117943001724 D-pathway; other site 1117943001725 Subunit I/VIIc interface [polypeptide binding]; other site 1117943001726 Subunit I/IV interface [polypeptide binding]; other site 1117943001727 Subunit I/II interface [polypeptide binding]; other site 1117943001728 Low-spin heme (heme a) binding site [chemical binding]; other site 1117943001729 Subunit I/VIIa interface [polypeptide binding]; other site 1117943001730 Subunit I/VIa interface [polypeptide binding]; other site 1117943001731 Dimer interface; other site 1117943001732 Putative water exit pathway; other site 1117943001733 Binuclear center (heme a3/CuB) [ion binding]; other site 1117943001734 K-pathway; other site 1117943001735 Subunit I/Vb interface [polypeptide binding]; other site 1117943001736 Putative proton exit pathway; other site 1117943001737 Subunit I/VIb interface; other site 1117943001738 Subunit I/VIc interface [polypeptide binding]; other site 1117943001739 Electron transfer pathway; other site 1117943001740 Subunit I/VIIIb interface [polypeptide binding]; other site 1117943001741 Subunit I/VIIb interface [polypeptide binding]; other site 1117943001742 Umbravirus long distance movement (LDM) family; Region: Umbravirus_LDM; pfam04817 1117943001743 Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175 1117943001744 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1117943001745 Subunit III/VIIa interface [polypeptide binding]; other site 1117943001746 Phospholipid binding site [chemical binding]; other site 1117943001747 Subunit I/III interface [polypeptide binding]; other site 1117943001748 Subunit III/VIb interface [polypeptide binding]; other site 1117943001749 Subunit III/VIa interface; other site 1117943001750 Subunit III/Vb interface [polypeptide binding]; other site 1117943001751 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1117943001752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 1117943001753 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1117943001754 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1117943001755 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1117943001756 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1117943001757 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1117943001758 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1117943001759 putative active site [active] 1117943001760 putative substrate binding site [chemical binding]; other site 1117943001761 ATP binding site [chemical binding]; other site 1117943001762 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1117943001763 RNA/DNA hybrid binding site [nucleotide binding]; other site 1117943001764 active site 1117943001765 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1117943001766 catalytic triad [active] 1117943001767 dimer interface [polypeptide binding]; other site 1117943001768 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1117943001769 hypothetical protein; Validated; Region: PRK00228 1117943001770 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1117943001771 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1117943001772 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943001773 PAS fold; Region: PAS_3; pfam08447 1117943001774 putative active site [active] 1117943001775 heme pocket [chemical binding]; other site 1117943001776 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943001777 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943001778 metal binding site [ion binding]; metal-binding site 1117943001779 active site 1117943001780 I-site; other site 1117943001781 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1117943001782 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1117943001783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1117943001784 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1117943001785 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1117943001786 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1117943001787 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1117943001788 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1117943001789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943001790 catalytic residue [active] 1117943001791 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1117943001792 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1117943001793 dimerization interface [polypeptide binding]; other site 1117943001794 ligand binding site [chemical binding]; other site 1117943001795 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1117943001796 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943001797 active site 1117943001798 motif I; other site 1117943001799 motif II; other site 1117943001800 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943001801 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943001802 DNA-binding site [nucleotide binding]; DNA binding site 1117943001803 FCD domain; Region: FCD; pfam07729 1117943001804 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943001805 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943001806 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943001807 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 1117943001808 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943001809 dimerization interface [polypeptide binding]; other site 1117943001810 putative DNA binding site [nucleotide binding]; other site 1117943001811 putative Zn2+ binding site [ion binding]; other site 1117943001812 NIPSNAP; Region: NIPSNAP; pfam07978 1117943001813 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1117943001814 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1117943001815 DNA methylase; Region: N6_N4_Mtase; pfam01555 1117943001816 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1117943001817 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1117943001818 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943001819 motif II; other site 1117943001820 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1117943001821 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1117943001822 minor groove reading motif; other site 1117943001823 helix-hairpin-helix signature motif; other site 1117943001824 substrate binding pocket [chemical binding]; other site 1117943001825 active site 1117943001826 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1117943001827 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1117943001828 DNA binding and oxoG recognition site [nucleotide binding] 1117943001829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389 1117943001830 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1117943001831 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1117943001832 catalytic residues [active] 1117943001833 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1117943001834 putative active site [active] 1117943001835 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1117943001836 AAA domain; Region: AAA_23; pfam13476 1117943001837 Walker A/P-loop; other site 1117943001838 ATP binding site [chemical binding]; other site 1117943001839 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1117943001840 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 1117943001841 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1117943001842 ABC transporter signature motif; other site 1117943001843 Walker B; other site 1117943001844 D-loop; other site 1117943001845 H-loop/switch region; other site 1117943001846 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1117943001847 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1117943001848 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1117943001849 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1117943001850 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 1117943001851 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1117943001852 Cupin domain; Region: Cupin_2; cl17218 1117943001853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 1117943001854 Putative glucoamylase; Region: Glycoamylase; pfam10091 1117943001855 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 1117943001856 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1117943001857 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 1117943001858 putative phosphoketolase; Provisional; Region: PRK05261 1117943001859 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1117943001860 TPP-binding site; other site 1117943001861 XFP C-terminal domain; Region: XFP_C; pfam09363 1117943001862 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1117943001863 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1117943001864 homodimer interface [polypeptide binding]; other site 1117943001865 active site pocket [active] 1117943001866 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1117943001867 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1117943001868 NAD binding site [chemical binding]; other site 1117943001869 substrate binding site [chemical binding]; other site 1117943001870 catalytic Zn binding site [ion binding]; other site 1117943001871 tetramer interface [polypeptide binding]; other site 1117943001872 structural Zn binding site [ion binding]; other site 1117943001873 FOG: CBS domain [General function prediction only]; Region: COG0517 1117943001874 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 1117943001875 BON domain; Region: BON; pfam04972 1117943001876 Uncharacterized conserved protein [Function unknown]; Region: COG3422 1117943001877 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1117943001878 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1117943001879 CysD dimerization site [polypeptide binding]; other site 1117943001880 G1 box; other site 1117943001881 putative GEF interaction site [polypeptide binding]; other site 1117943001882 GTP/Mg2+ binding site [chemical binding]; other site 1117943001883 Switch I region; other site 1117943001884 G2 box; other site 1117943001885 G3 box; other site 1117943001886 Switch II region; other site 1117943001887 G4 box; other site 1117943001888 G5 box; other site 1117943001889 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1117943001890 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1117943001891 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1117943001892 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1117943001893 Active Sites [active] 1117943001894 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1117943001895 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1117943001896 Active Sites [active] 1117943001897 choline dehydrogenase; Validated; Region: PRK02106 1117943001898 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1117943001899 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1117943001900 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1117943001901 NAD(P) binding site [chemical binding]; other site 1117943001902 catalytic residues [active] 1117943001903 Sulfatase; Region: Sulfatase; cl17466 1117943001904 choline-sulfatase; Region: chol_sulfatase; TIGR03417 1117943001905 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 1117943001906 transcriptional regulator BetI; Validated; Region: PRK00767 1117943001907 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943001908 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1117943001909 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1117943001910 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1117943001911 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1117943001912 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943001913 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943001914 metal binding site [ion binding]; metal-binding site 1117943001915 active site 1117943001916 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1117943001917 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1117943001918 NAD(P) binding site [chemical binding]; other site 1117943001919 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 1117943001920 L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448 1117943001921 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1117943001922 glutathionine S-transferase; Provisional; Region: PRK10542 1117943001923 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1117943001924 C-terminal domain interface [polypeptide binding]; other site 1117943001925 GSH binding site (G-site) [chemical binding]; other site 1117943001926 dimer interface [polypeptide binding]; other site 1117943001927 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1117943001928 dimer interface [polypeptide binding]; other site 1117943001929 N-terminal domain interface [polypeptide binding]; other site 1117943001930 substrate binding pocket (H-site) [chemical binding]; other site 1117943001931 Protein of unknown function (DUF419); Region: DUF419; cl15265 1117943001932 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1117943001933 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943001934 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1117943001935 dimerization interface [polypeptide binding]; other site 1117943001936 substrate binding pocket [chemical binding]; other site 1117943001937 potential frameshift: common BLAST hit: gi|227821289|ref|YP_002825259.1| glutathione-S-transferase 1117943001938 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1117943001939 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1117943001940 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 1117943001941 dimer interface [polypeptide binding]; other site 1117943001942 N-terminal domain interface [polypeptide binding]; other site 1117943001943 putative substrate binding pocket (H-site) [chemical binding]; other site 1117943001944 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1117943001945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1117943001946 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1117943001947 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1117943001948 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943001949 putative Zn2+ binding site [ion binding]; other site 1117943001950 putative DNA binding site [nucleotide binding]; other site 1117943001951 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1117943001952 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1117943001953 PhnA protein; Region: PhnA; pfam03831 1117943001954 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1117943001955 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1117943001956 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1117943001957 active site 1117943001958 catalytic tetrad [active] 1117943001959 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1117943001960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943001961 S-adenosylmethionine binding site [chemical binding]; other site 1117943001962 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1117943001963 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943001964 motif II; other site 1117943001965 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 1117943001966 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1117943001967 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 1117943001968 putative NAD(P) binding site [chemical binding]; other site 1117943001969 catalytic Zn binding site [ion binding]; other site 1117943001970 structural Zn binding site [ion binding]; other site 1117943001971 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1117943001972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943001973 aminotransferase; Provisional; Region: PRK13356 1117943001974 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1117943001975 homodimer interface [polypeptide binding]; other site 1117943001976 substrate-cofactor binding pocket; other site 1117943001977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943001978 catalytic residue [active] 1117943001979 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1117943001980 dimer interface [polypeptide binding]; other site 1117943001981 ligand binding site [chemical binding]; other site 1117943001982 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1117943001983 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943001984 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1117943001985 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1117943001986 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1117943001987 Predicted transcriptional regulator [Transcription]; Region: COG2378 1117943001988 HTH domain; Region: HTH_11; pfam08279 1117943001989 WYL domain; Region: WYL; pfam13280 1117943001990 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1117943001991 Cytochrome c556 [Energy production and conversion]; Region: COG3909 1117943001992 Cytochrome c; Region: Cytochrom_C; pfam00034 1117943001993 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1117943001994 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1117943001995 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943001996 Coenzyme A binding pocket [chemical binding]; other site 1117943001997 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 1117943001998 DNA binding residues [nucleotide binding] 1117943001999 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1117943002000 dimer interface [polypeptide binding]; other site 1117943002001 putative metal binding site [ion binding]; other site 1117943002002 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1117943002003 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1117943002004 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1117943002005 Trp docking motif [polypeptide binding]; other site 1117943002006 putative active site [active] 1117943002007 hypothetical protein; Validated; Region: PRK00029 1117943002008 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1117943002009 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1117943002010 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1117943002011 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 1117943002012 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1117943002013 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1117943002014 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1117943002015 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1117943002016 putative metal binding site [ion binding]; other site 1117943002017 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1117943002018 active site 1117943002019 metal binding site [ion binding]; metal-binding site 1117943002020 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1117943002021 Ligand Binding Site [chemical binding]; other site 1117943002022 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1117943002023 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1117943002024 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1117943002025 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1117943002026 SelR domain; Region: SelR; pfam01641 1117943002027 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 1117943002028 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1117943002029 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1117943002030 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1117943002031 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12658 1117943002032 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1117943002033 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 1117943002034 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1117943002035 Predicted transcriptional regulator [Transcription]; Region: COG4957 1117943002036 hypothetical protein; Region: PHA00616 1117943002037 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1117943002038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943002039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943002040 dimer interface [polypeptide binding]; other site 1117943002041 phosphorylation site [posttranslational modification] 1117943002042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943002043 ATP binding site [chemical binding]; other site 1117943002044 Mg2+ binding site [ion binding]; other site 1117943002045 G-X-G motif; other site 1117943002046 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1117943002047 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1117943002048 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1117943002049 Uncharacterized conserved protein [Function unknown]; Region: COG5447 1117943002050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 1117943002051 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1117943002052 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1117943002053 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1117943002054 Bacterial SH3 domain; Region: SH3_3; pfam08239 1117943002055 Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253 1117943002056 Predicted integral membrane protein [Function unknown]; Region: COG5436 1117943002057 Uncharacterized conserved protein [Function unknown]; Region: COG5402 1117943002058 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1117943002059 Transglycosylase; Region: Transgly; pfam00912 1117943002060 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1117943002061 hypothetical protein; Provisional; Region: PRK05170 1117943002062 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1117943002063 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1117943002064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943002065 active site 1117943002066 phosphorylation site [posttranslational modification] 1117943002067 intermolecular recognition site; other site 1117943002068 dimerization interface [polypeptide binding]; other site 1117943002069 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943002070 DNA binding site [nucleotide binding] 1117943002071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943002072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943002073 ATP binding site [chemical binding]; other site 1117943002074 Mg2+ binding site [ion binding]; other site 1117943002075 G-X-G motif; other site 1117943002076 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 1117943002077 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1117943002078 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1117943002079 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 1117943002080 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1117943002081 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1117943002082 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1117943002083 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1117943002084 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943002085 protein binding site [polypeptide binding]; other site 1117943002086 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943002087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1117943002088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943002089 active site 1117943002090 phosphorylation site [posttranslational modification] 1117943002091 intermolecular recognition site; other site 1117943002092 dimerization interface [polypeptide binding]; other site 1117943002093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943002094 DNA binding site [nucleotide binding] 1117943002095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943002096 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943002097 dimerization interface [polypeptide binding]; other site 1117943002098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943002099 dimer interface [polypeptide binding]; other site 1117943002100 phosphorylation site [posttranslational modification] 1117943002101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943002102 ATP binding site [chemical binding]; other site 1117943002103 Mg2+ binding site [ion binding]; other site 1117943002104 G-X-G motif; other site 1117943002105 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 1117943002106 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1117943002107 metal binding triad; other site 1117943002108 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1117943002109 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1117943002110 metal binding triad; other site 1117943002111 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943002112 PAS fold; Region: PAS_3; pfam08447 1117943002113 putative active site [active] 1117943002114 heme pocket [chemical binding]; other site 1117943002115 PAS fold; Region: PAS_7; pfam12860 1117943002116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943002117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943002118 dimer interface [polypeptide binding]; other site 1117943002119 phosphorylation site [posttranslational modification] 1117943002120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943002121 ATP binding site [chemical binding]; other site 1117943002122 Mg2+ binding site [ion binding]; other site 1117943002123 G-X-G motif; other site 1117943002124 aminopeptidase N; Provisional; Region: pepN; PRK14015 1117943002125 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1117943002126 active site 1117943002127 Zn binding site [ion binding]; other site 1117943002128 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1117943002129 EamA-like transporter family; Region: EamA; pfam00892 1117943002130 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1117943002131 Fe-S cluster binding site [ion binding]; other site 1117943002132 active site 1117943002133 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1117943002134 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1117943002135 nucleotide binding site [chemical binding]; other site 1117943002136 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1117943002137 SBD interface [polypeptide binding]; other site 1117943002138 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1117943002139 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1117943002140 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1117943002141 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1117943002142 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1117943002143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943002144 dimer interface [polypeptide binding]; other site 1117943002145 conserved gate region; other site 1117943002146 putative PBP binding loops; other site 1117943002147 ABC-ATPase subunit interface; other site 1117943002148 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943002149 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943002150 dimerization interface [polypeptide binding]; other site 1117943002151 putative DNA binding site [nucleotide binding]; other site 1117943002152 putative Zn2+ binding site [ion binding]; other site 1117943002153 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943002154 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1117943002155 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1117943002156 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1117943002157 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1117943002158 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1117943002159 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1117943002160 Ligand binding site; other site 1117943002161 Putative Catalytic site; other site 1117943002162 DXD motif; other site 1117943002163 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1117943002164 AMP nucleosidase; Provisional; Region: PRK08292 1117943002165 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1117943002166 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1117943002167 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1117943002168 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1117943002169 C-terminal domain interface [polypeptide binding]; other site 1117943002170 GSH binding site (G-site) [chemical binding]; other site 1117943002171 dimer interface [polypeptide binding]; other site 1117943002172 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1117943002173 N-terminal domain interface [polypeptide binding]; other site 1117943002174 putative dimer interface [polypeptide binding]; other site 1117943002175 active site 1117943002176 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 1117943002177 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1117943002178 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 1117943002179 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943002180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943002181 homodimer interface [polypeptide binding]; other site 1117943002182 catalytic residue [active] 1117943002183 PilZ domain; Region: PilZ; pfam07238 1117943002184 Porin subfamily; Region: Porin_2; pfam02530 1117943002185 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1117943002186 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943002187 active site 1117943002188 DNA binding site [nucleotide binding] 1117943002189 Int/Topo IB signature motif; other site 1117943002190 Porin subfamily; Region: Porin_2; pfam02530 1117943002191 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1117943002192 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1117943002193 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1117943002194 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1117943002195 catalytic residue [active] 1117943002196 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1117943002197 SmpB-tmRNA interface; other site 1117943002198 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1117943002199 LabA_like proteins; Region: LabA; cd10911 1117943002200 putative metal binding site [ion binding]; other site 1117943002201 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1117943002202 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1117943002203 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1117943002204 Zn2+ binding site [ion binding]; other site 1117943002205 Mg2+ binding site [ion binding]; other site 1117943002206 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1117943002207 synthetase active site [active] 1117943002208 NTP binding site [chemical binding]; other site 1117943002209 metal binding site [ion binding]; metal-binding site 1117943002210 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1117943002211 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1117943002212 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 1117943002213 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1117943002214 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1117943002215 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1117943002216 Catalytic site [active] 1117943002217 ribonuclease III; Reviewed; Region: PRK12371 1117943002218 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1117943002219 dimerization interface [polypeptide binding]; other site 1117943002220 active site 1117943002221 metal binding site [ion binding]; metal-binding site 1117943002222 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1117943002223 dsRNA binding site [nucleotide binding]; other site 1117943002224 GTPase Era; Reviewed; Region: era; PRK00089 1117943002225 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1117943002226 G1 box; other site 1117943002227 GTP/Mg2+ binding site [chemical binding]; other site 1117943002228 Switch I region; other site 1117943002229 G2 box; other site 1117943002230 Switch II region; other site 1117943002231 G3 box; other site 1117943002232 G4 box; other site 1117943002233 G5 box; other site 1117943002234 KH domain; Region: KH_2; pfam07650 1117943002235 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 1117943002236 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1117943002237 putative active site [active] 1117943002238 catalytic site [active] 1117943002239 putative metal binding site [ion binding]; other site 1117943002240 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1117943002241 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1117943002242 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1117943002243 putative dimer interface [polypeptide binding]; other site 1117943002244 N-terminal domain interface [polypeptide binding]; other site 1117943002245 putative substrate binding pocket (H-site) [chemical binding]; other site 1117943002246 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1117943002247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943002248 S-adenosylmethionine binding site [chemical binding]; other site 1117943002249 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1117943002250 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1117943002251 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1117943002252 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1117943002253 RNA binding site [nucleotide binding]; other site 1117943002254 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1117943002255 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1117943002256 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1117943002257 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1117943002258 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1117943002259 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1117943002260 putative NAD(P) binding site [chemical binding]; other site 1117943002261 active site 1117943002262 putative substrate binding site [chemical binding]; other site 1117943002263 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943002264 dimerization interface [polypeptide binding]; other site 1117943002265 putative DNA binding site [nucleotide binding]; other site 1117943002266 putative Zn2+ binding site [ion binding]; other site 1117943002267 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1117943002268 hydrophobic ligand binding site; other site 1117943002269 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1117943002270 active site 1117943002271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1117943002272 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1117943002273 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1117943002274 Recombination protein O N terminal; Region: RecO_N; pfam11967 1117943002275 Recombination protein O C terminal; Region: RecO_C; pfam02565 1117943002276 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1117943002277 Predicted membrane protein [Function unknown]; Region: COG5373 1117943002278 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1117943002279 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1117943002280 Zn2+ binding site [ion binding]; other site 1117943002281 Mg2+ binding site [ion binding]; other site 1117943002282 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1117943002283 MOSC domain; Region: MOSC; pfam03473 1117943002284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943002285 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1117943002286 putative substrate translocation pore; other site 1117943002287 quinolinate synthetase; Provisional; Region: PRK09375 1117943002288 L-aspartate oxidase; Provisional; Region: PRK07512 1117943002289 L-aspartate oxidase; Provisional; Region: PRK06175 1117943002290 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1117943002291 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 1117943002292 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1117943002293 dimerization interface [polypeptide binding]; other site 1117943002294 active site 1117943002295 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1117943002296 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1117943002297 E-class dimer interface [polypeptide binding]; other site 1117943002298 P-class dimer interface [polypeptide binding]; other site 1117943002299 active site 1117943002300 Cu2+ binding site [ion binding]; other site 1117943002301 Zn2+ binding site [ion binding]; other site 1117943002302 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1117943002303 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 1117943002304 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1117943002305 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1117943002306 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1117943002307 Protein of unknown function (DUF2385); Region: DUF2385; cl11490 1117943002308 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1117943002309 nudix motif; other site 1117943002310 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1117943002311 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1117943002312 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1117943002313 active site 1117943002314 HIGH motif; other site 1117943002315 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1117943002316 KMSKS motif; other site 1117943002317 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1117943002318 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1117943002319 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1117943002320 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1117943002321 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1117943002322 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1117943002323 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1117943002324 active site 1117943002325 catalytic residues [active] 1117943002326 metal binding site [ion binding]; metal-binding site 1117943002327 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1117943002328 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1117943002329 EamA-like transporter family; Region: EamA; pfam00892 1117943002330 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1117943002331 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1117943002332 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1117943002333 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1117943002334 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1117943002335 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1117943002336 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 1117943002337 Walker A/P-loop; other site 1117943002338 ATP binding site [chemical binding]; other site 1117943002339 Q-loop/lid; other site 1117943002340 ABC transporter signature motif; other site 1117943002341 Walker B; other site 1117943002342 D-loop; other site 1117943002343 H-loop/switch region; other site 1117943002344 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1117943002345 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1117943002346 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1117943002347 CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009 1117943002348 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1117943002349 classical (c) SDRs; Region: SDR_c; cd05233 1117943002350 NAD(P) binding site [chemical binding]; other site 1117943002351 active site 1117943002352 amidophosphoribosyltransferase; Provisional; Region: PRK09123 1117943002353 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1117943002354 active site 1117943002355 tetramer interface [polypeptide binding]; other site 1117943002356 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1117943002357 active site 1117943002358 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1117943002359 Colicin V production protein; Region: Colicin_V; pfam02674 1117943002360 DNA repair protein RadA; Provisional; Region: PRK11823 1117943002361 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1117943002362 Walker A motif/ATP binding site; other site 1117943002363 ATP binding site [chemical binding]; other site 1117943002364 Walker B motif; other site 1117943002365 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1117943002366 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1117943002367 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1117943002368 active site 1117943002369 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1117943002370 dimer interface [polypeptide binding]; other site 1117943002371 substrate binding site [chemical binding]; other site 1117943002372 catalytic residues [active] 1117943002373 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1117943002374 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1117943002375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943002376 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943002377 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1117943002378 Predicted membrane protein [Function unknown]; Region: COG4541 1117943002379 replicative DNA helicase; Provisional; Region: PRK09165 1117943002380 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1117943002381 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1117943002382 Walker A motif; other site 1117943002383 ATP binding site [chemical binding]; other site 1117943002384 Walker B motif; other site 1117943002385 DNA binding loops [nucleotide binding] 1117943002386 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1117943002387 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1117943002388 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1117943002389 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1117943002390 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1117943002391 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1117943002392 dimerization interface [polypeptide binding]; other site 1117943002393 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1117943002394 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1117943002395 active site 1117943002396 catalytic tetrad [active] 1117943002397 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1117943002398 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1117943002399 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 1117943002400 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1117943002401 NAD(P) binding site [chemical binding]; other site 1117943002402 homotetramer interface [polypeptide binding]; other site 1117943002403 homodimer interface [polypeptide binding]; other site 1117943002404 active site 1117943002405 acyl carrier protein; Provisional; Region: acpP; PRK00982 1117943002406 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1117943002407 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1117943002408 dimer interface [polypeptide binding]; other site 1117943002409 active site 1117943002410 YceG-like family; Region: YceG; pfam02618 1117943002411 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1117943002412 dimerization interface [polypeptide binding]; other site 1117943002413 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 1117943002414 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1117943002415 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1117943002416 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1117943002417 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1117943002418 catalytic site [active] 1117943002419 G-X2-G-X-G-K; other site 1117943002420 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1117943002421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943002422 S-adenosylmethionine binding site [chemical binding]; other site 1117943002423 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 1117943002424 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1117943002425 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1117943002426 SurA N-terminal domain; Region: SurA_N; pfam09312 1117943002427 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1117943002428 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1117943002429 Predicted permeases [General function prediction only]; Region: COG0795 1117943002430 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1117943002431 Predicted permeases [General function prediction only]; Region: COG0795 1117943002432 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1117943002433 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1117943002434 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1117943002435 interface (dimer of trimers) [polypeptide binding]; other site 1117943002436 Substrate-binding/catalytic site; other site 1117943002437 Zn-binding sites [ion binding]; other site 1117943002438 DNA polymerase III subunit chi; Validated; Region: PRK05728 1117943002439 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943002440 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943002441 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943002442 Coenzyme A binding pocket [chemical binding]; other site 1117943002443 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1117943002444 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1117943002445 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1117943002446 ABC transporter; Region: ABC_tran_2; pfam12848 1117943002447 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1117943002448 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1117943002449 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1117943002450 acyl-activating enzyme (AAE) consensus motif; other site 1117943002451 AMP binding site [chemical binding]; other site 1117943002452 active site 1117943002453 CoA binding site [chemical binding]; other site 1117943002454 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1117943002455 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1117943002456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1117943002457 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038 1117943002458 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1117943002459 putative C-terminal domain interface [polypeptide binding]; other site 1117943002460 putative GSH binding site (G-site) [chemical binding]; other site 1117943002461 putative dimer interface [polypeptide binding]; other site 1117943002462 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 1117943002463 putative N-terminal domain interface [polypeptide binding]; other site 1117943002464 putative dimer interface [polypeptide binding]; other site 1117943002465 putative substrate binding pocket (H-site) [chemical binding]; other site 1117943002466 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1117943002467 active site 1117943002468 multimer interface [polypeptide binding]; other site 1117943002469 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1117943002470 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1117943002471 CGNR zinc finger; Region: zf-CGNR; pfam11706 1117943002472 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1117943002473 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943002474 TM-ABC transporter signature motif; other site 1117943002475 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1117943002476 MoaE homodimer interface [polypeptide binding]; other site 1117943002477 MoaD interaction [polypeptide binding]; other site 1117943002478 active site residues [active] 1117943002479 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1117943002480 MoaE interaction surface [polypeptide binding]; other site 1117943002481 MoeB interaction surface [polypeptide binding]; other site 1117943002482 thiocarboxylated glycine; other site 1117943002483 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1117943002484 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1117943002485 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1117943002486 GIY-YIG motif/motif A; other site 1117943002487 active site 1117943002488 catalytic site [active] 1117943002489 putative DNA binding site [nucleotide binding]; other site 1117943002490 metal binding site [ion binding]; metal-binding site 1117943002491 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1117943002492 short chain dehydrogenase; Provisional; Region: PRK09134 1117943002493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943002494 NAD(P) binding site [chemical binding]; other site 1117943002495 active site 1117943002496 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1117943002497 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1117943002498 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1117943002499 putative C-terminal domain interface [polypeptide binding]; other site 1117943002500 putative GSH binding site (G-site) [chemical binding]; other site 1117943002501 putative dimer interface [polypeptide binding]; other site 1117943002502 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1117943002503 N-terminal domain interface [polypeptide binding]; other site 1117943002504 dimer interface [polypeptide binding]; other site 1117943002505 putative substrate binding pocket (H-site) [chemical binding]; other site 1117943002506 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1117943002507 B1 nucleotide binding pocket [chemical binding]; other site 1117943002508 B2 nucleotide binding pocket [chemical binding]; other site 1117943002509 CAS motifs; other site 1117943002510 active site 1117943002511 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1117943002512 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1117943002513 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1117943002514 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1117943002515 putative [4Fe-4S] binding site [ion binding]; other site 1117943002516 putative molybdopterin cofactor binding site [chemical binding]; other site 1117943002517 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1117943002518 molybdopterin cofactor binding site; other site 1117943002519 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1117943002520 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1117943002521 dimer interface [polypeptide binding]; other site 1117943002522 ADP-ribose binding site [chemical binding]; other site 1117943002523 active site 1117943002524 nudix motif; other site 1117943002525 metal binding site [ion binding]; metal-binding site 1117943002526 Predicted integral membrane protein [Function unknown]; Region: COG0392 1117943002527 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1117943002528 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1117943002529 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 1117943002530 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 1117943002531 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1117943002532 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1117943002533 active site 1117943002534 substrate binding site [chemical binding]; other site 1117943002535 cosubstrate binding site; other site 1117943002536 catalytic site [active] 1117943002537 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1117943002538 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1117943002539 dimerization interface [polypeptide binding]; other site 1117943002540 putative ATP binding site [chemical binding]; other site 1117943002541 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1117943002542 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1117943002543 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1117943002544 hypothetical protein; Validated; Region: PRK09087 1117943002545 polyphosphate kinase; Provisional; Region: PRK05443 1117943002546 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1117943002547 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1117943002548 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1117943002549 putative domain interface [polypeptide binding]; other site 1117943002550 putative active site [active] 1117943002551 catalytic site [active] 1117943002552 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1117943002553 putative domain interface [polypeptide binding]; other site 1117943002554 putative active site [active] 1117943002555 catalytic site [active] 1117943002556 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1117943002557 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1117943002558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 1117943002559 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 1117943002560 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943002561 Helix-turn-helix domain; Region: HTH_28; pfam13518 1117943002562 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943002563 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943002564 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943002565 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943002566 cyclase homology domain; Region: CHD; cd07302 1117943002567 nucleotidyl binding site; other site 1117943002568 metal binding site [ion binding]; metal-binding site 1117943002569 dimer interface [polypeptide binding]; other site 1117943002570 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1117943002571 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943002572 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943002573 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1117943002574 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1117943002575 catalytic site [active] 1117943002576 putative active site [active] 1117943002577 putative substrate binding site [chemical binding]; other site 1117943002578 HRDC domain; Region: HRDC; pfam00570 1117943002579 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1117943002580 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1117943002581 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1117943002582 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1117943002583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943002584 putative MFS family transporter protein; Provisional; Region: PRK03633 1117943002585 putative substrate translocation pore; other site 1117943002586 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1117943002587 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1117943002588 dimer interface [polypeptide binding]; other site 1117943002589 anticodon binding site; other site 1117943002590 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1117943002591 homodimer interface [polypeptide binding]; other site 1117943002592 motif 1; other site 1117943002593 active site 1117943002594 motif 2; other site 1117943002595 GAD domain; Region: GAD; pfam02938 1117943002596 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1117943002597 active site 1117943002598 motif 3; other site 1117943002599 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 1117943002600 active site 1117943002601 catalytic residue [active] 1117943002602 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1117943002603 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1117943002604 ring oligomerisation interface [polypeptide binding]; other site 1117943002605 ATP/Mg binding site [chemical binding]; other site 1117943002606 stacking interactions; other site 1117943002607 hinge regions; other site 1117943002608 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1117943002609 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1117943002610 CAP-like domain; other site 1117943002611 active site 1117943002612 primary dimer interface [polypeptide binding]; other site 1117943002613 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943002614 putative DNA binding site [nucleotide binding]; other site 1117943002615 putative Zn2+ binding site [ion binding]; other site 1117943002616 EamA-like transporter family; Region: EamA; pfam00892 1117943002617 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1117943002618 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 1117943002619 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1117943002620 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1117943002621 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1117943002622 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1117943002623 dimer interface [polypeptide binding]; other site 1117943002624 allosteric magnesium binding site [ion binding]; other site 1117943002625 active site 1117943002626 aspartate-rich active site metal binding site; other site 1117943002627 Schiff base residues; other site 1117943002628 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1117943002629 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1117943002630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1117943002631 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1117943002632 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1117943002633 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1117943002634 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1117943002635 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1117943002636 dimer interface [polypeptide binding]; other site 1117943002637 active site 1117943002638 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1117943002639 folate binding site [chemical binding]; other site 1117943002640 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1117943002641 ATP cone domain; Region: ATP-cone; pfam03477 1117943002642 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1117943002643 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1117943002644 catalytic motif [active] 1117943002645 Zn binding site [ion binding]; other site 1117943002646 RibD C-terminal domain; Region: RibD_C; cl17279 1117943002647 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1117943002648 Lumazine binding domain; Region: Lum_binding; pfam00677 1117943002649 Lumazine binding domain; Region: Lum_binding; pfam00677 1117943002650 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1117943002651 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1117943002652 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 1117943002653 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1117943002654 homopentamer interface [polypeptide binding]; other site 1117943002655 active site 1117943002656 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1117943002657 putative RNA binding site [nucleotide binding]; other site 1117943002658 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 1117943002659 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1117943002660 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1117943002661 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1117943002662 Uncharacterized conserved protein [Function unknown]; Region: COG5452 1117943002663 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1117943002664 putative phosphate acyltransferase; Provisional; Region: PRK05331 1117943002665 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1117943002666 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1117943002667 dimer interface [polypeptide binding]; other site 1117943002668 active site 1117943002669 CoA binding pocket [chemical binding]; other site 1117943002670 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1117943002671 IHF dimer interface [polypeptide binding]; other site 1117943002672 IHF - DNA interface [nucleotide binding]; other site 1117943002673 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1117943002674 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1117943002675 DNA binding residues [nucleotide binding] 1117943002676 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1117943002677 Ligand Binding Site [chemical binding]; other site 1117943002678 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1117943002679 putative protease; Provisional; Region: PRK15447 1117943002680 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1117943002681 Peptidase family U32; Region: Peptidase_U32; pfam01136 1117943002682 SCP-2 sterol transfer family; Region: SCP2; cl01225 1117943002683 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1117943002684 NnrU protein; Region: NnrU; cl17713 1117943002685 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1117943002686 Subunit I/III interface [polypeptide binding]; other site 1117943002687 Cytochrome c; Region: Cytochrom_C; pfam00034 1117943002688 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1117943002689 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1117943002690 D-pathway; other site 1117943002691 K-pathway; other site 1117943002692 Binuclear center (active site) [active] 1117943002693 Putative proton exit pathway; other site 1117943002694 MoxR-like ATPases [General function prediction only]; Region: COG0714 1117943002695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943002696 Walker A motif; other site 1117943002697 ATP binding site [chemical binding]; other site 1117943002698 Walker B motif; other site 1117943002699 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1117943002700 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1117943002701 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1117943002702 metal ion-dependent adhesion site (MIDAS); other site 1117943002703 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1117943002704 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1117943002705 FeS/SAM binding site; other site 1117943002706 HemN C-terminal domain; Region: HemN_C; pfam06969 1117943002707 Uncharacterized conserved protein [Function unknown]; Region: COG4309 1117943002708 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1117943002709 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1117943002710 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1117943002711 Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213 1117943002712 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1117943002713 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1117943002714 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1117943002715 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1117943002716 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1117943002717 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1117943002718 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1117943002719 ligand binding site [chemical binding]; other site 1117943002720 flexible hinge region; other site 1117943002721 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1117943002722 putative switch regulator; other site 1117943002723 non-specific DNA interactions [nucleotide binding]; other site 1117943002724 DNA binding site [nucleotide binding] 1117943002725 sequence specific DNA binding site [nucleotide binding]; other site 1117943002726 putative cAMP binding site [chemical binding]; other site 1117943002727 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1117943002728 pseudoazurin; Region: pseudoazurin; TIGR02375 1117943002729 Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848 1117943002730 NapD protein; Region: NapD; cl01163 1117943002731 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1117943002732 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1117943002733 [4Fe-4S] binding site [ion binding]; other site 1117943002734 molybdopterin cofactor binding site; other site 1117943002735 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1117943002736 molybdopterin cofactor binding site; other site 1117943002737 Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043 1117943002738 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 1117943002739 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1117943002740 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1117943002741 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1117943002742 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1117943002743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1117943002744 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943002745 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943002746 Winged helix-turn helix; Region: HTH_33; pfam13592 1117943002747 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943002748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943002749 O-Antigen ligase; Region: Wzy_C; pfam04932 1117943002750 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1117943002751 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1117943002752 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1117943002753 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1117943002754 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1117943002755 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1117943002756 SLBB domain; Region: SLBB; pfam10531 1117943002757 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 1117943002758 Chain length determinant protein; Region: Wzz; pfam02706 1117943002759 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 1117943002760 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1117943002761 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1117943002762 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1117943002763 trimer interface [polypeptide binding]; other site 1117943002764 active site 1117943002765 substrate binding site [chemical binding]; other site 1117943002766 CoA binding site [chemical binding]; other site 1117943002767 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1117943002768 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1117943002769 active site 1117943002770 metal binding site [ion binding]; metal-binding site 1117943002771 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 1117943002772 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 1117943002773 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1117943002774 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 1117943002775 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1117943002776 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1117943002777 agmatinase; Region: agmatinase; TIGR01230 1117943002778 oligomer interface [polypeptide binding]; other site 1117943002779 putative active site [active] 1117943002780 Mn binding site [ion binding]; other site 1117943002781 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1117943002782 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1117943002783 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1117943002784 23S rRNA interface [nucleotide binding]; other site 1117943002785 L3 interface [polypeptide binding]; other site 1117943002786 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1117943002787 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1117943002788 CoenzymeA binding site [chemical binding]; other site 1117943002789 subunit interaction site [polypeptide binding]; other site 1117943002790 PHB binding site; other site 1117943002791 enoyl-CoA hydratase; Validated; Region: PRK08139 1117943002792 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1117943002793 substrate binding site [chemical binding]; other site 1117943002794 oxyanion hole (OAH) forming residues; other site 1117943002795 trimer interface [polypeptide binding]; other site 1117943002796 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1117943002797 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1117943002798 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1117943002799 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 1117943002800 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1117943002801 homodimer interface [polypeptide binding]; other site 1117943002802 substrate-cofactor binding pocket; other site 1117943002803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943002804 catalytic residue [active] 1117943002805 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1117943002806 Right handed beta helix region; Region: Beta_helix; pfam13229 1117943002807 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1117943002808 Cytochrome P450; Region: p450; cl12078 1117943002809 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1117943002810 putative catalytic site [active] 1117943002811 putative metal binding site [ion binding]; other site 1117943002812 putative phosphate binding site [ion binding]; other site 1117943002813 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1117943002814 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1117943002815 putative active site [active] 1117943002816 catalytic site [active] 1117943002817 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1117943002818 putative active site [active] 1117943002819 catalytic site [active] 1117943002820 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1117943002821 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1117943002822 oligomer interface [polypeptide binding]; other site 1117943002823 active site residues [active] 1117943002824 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1117943002825 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1117943002826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943002827 Walker A motif; other site 1117943002828 ATP binding site [chemical binding]; other site 1117943002829 Walker B motif; other site 1117943002830 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1117943002831 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1117943002832 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1117943002833 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1117943002834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943002835 Walker A motif; other site 1117943002836 ATP binding site [chemical binding]; other site 1117943002837 Walker B motif; other site 1117943002838 arginine finger; other site 1117943002839 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1117943002840 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1117943002841 IHF dimer interface [polypeptide binding]; other site 1117943002842 IHF - DNA interface [nucleotide binding]; other site 1117943002843 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1117943002844 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1117943002845 MarR family; Region: MarR; pfam01047 1117943002846 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1117943002847 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943002848 dimerization interface [polypeptide binding]; other site 1117943002849 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1117943002850 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1117943002851 dimer interface [polypeptide binding]; other site 1117943002852 putative CheW interface [polypeptide binding]; other site 1117943002853 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1117943002854 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1117943002855 active site 1117943002856 metal binding site [ion binding]; metal-binding site 1117943002857 DNA binding site [nucleotide binding] 1117943002858 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1117943002859 AAA domain; Region: AAA_23; pfam13476 1117943002860 AAA domain; Region: AAA_27; pfam13514 1117943002861 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1117943002862 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1117943002863 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1117943002864 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 1117943002865 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1117943002866 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1117943002867 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1117943002868 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1117943002869 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1117943002870 putative dimer interface [polypeptide binding]; other site 1117943002871 [2Fe-2S] cluster binding site [ion binding]; other site 1117943002872 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 1117943002873 SLBB domain; Region: SLBB; pfam10531 1117943002874 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1117943002875 Uncharacterized conserved protein [Function unknown]; Region: COG3743 1117943002876 NADH dehydrogenase subunit G; Validated; Region: PRK09130 1117943002877 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1117943002878 catalytic loop [active] 1117943002879 iron binding site [ion binding]; other site 1117943002880 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1117943002881 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 1117943002882 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 1117943002883 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1117943002884 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1117943002885 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1117943002886 4Fe-4S binding domain; Region: Fer4; pfam00037 1117943002887 4Fe-4S binding domain; Region: Fer4; pfam00037 1117943002888 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1117943002889 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1117943002890 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 1117943002891 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1117943002892 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1117943002893 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 1117943002894 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1117943002895 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1117943002896 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1117943002897 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1117943002898 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1117943002899 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1117943002900 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1117943002901 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1117943002902 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1117943002903 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1117943002904 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1117943002905 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1117943002906 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943002907 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1117943002908 dimer interface [polypeptide binding]; other site 1117943002909 substrate binding site [chemical binding]; other site 1117943002910 metal binding site [ion binding]; metal-binding site 1117943002911 Protein of unknown function (DUF1467); Region: DUF1467; cl11569 1117943002912 prolyl-tRNA synthetase; Provisional; Region: PRK12325 1117943002913 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1117943002914 dimer interface [polypeptide binding]; other site 1117943002915 motif 1; other site 1117943002916 active site 1117943002917 motif 2; other site 1117943002918 motif 3; other site 1117943002919 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1117943002920 anticodon binding site; other site 1117943002921 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1117943002922 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1117943002923 FtsX-like permease family; Region: FtsX; pfam02687 1117943002924 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1117943002925 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1117943002926 Walker A/P-loop; other site 1117943002927 ATP binding site [chemical binding]; other site 1117943002928 Q-loop/lid; other site 1117943002929 ABC transporter signature motif; other site 1117943002930 Walker B; other site 1117943002931 D-loop; other site 1117943002932 H-loop/switch region; other site 1117943002933 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1117943002934 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1117943002935 putative active site [active] 1117943002936 putative PHP Thumb interface [polypeptide binding]; other site 1117943002937 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1117943002938 generic binding surface II; other site 1117943002939 generic binding surface I; other site 1117943002940 hypothetical protein; Provisional; Region: PRK06132 1117943002941 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1117943002942 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1117943002943 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1117943002944 DNA polymerase IV; Provisional; Region: PRK02794 1117943002945 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1117943002946 active site 1117943002947 DNA binding site [nucleotide binding] 1117943002948 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1117943002949 Coenzyme A binding pocket [chemical binding]; other site 1117943002950 hypothetical protein; Provisional; Region: 30.2; PHA02597 1117943002951 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 1117943002952 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1117943002953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943002954 active site 1117943002955 phosphorylation site [posttranslational modification] 1117943002956 intermolecular recognition site; other site 1117943002957 dimerization interface [polypeptide binding]; other site 1117943002958 response regulator PleD; Reviewed; Region: pleD; PRK09581 1117943002959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943002960 active site 1117943002961 phosphorylation site [posttranslational modification] 1117943002962 intermolecular recognition site; other site 1117943002963 dimerization interface [polypeptide binding]; other site 1117943002964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943002965 active site 1117943002966 phosphorylation site [posttranslational modification] 1117943002967 intermolecular recognition site; other site 1117943002968 dimerization interface [polypeptide binding]; other site 1117943002969 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943002970 metal binding site [ion binding]; metal-binding site 1117943002971 active site 1117943002972 I-site; other site 1117943002973 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1117943002974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943002975 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1117943002976 putative substrate translocation pore; other site 1117943002977 hypothetical protein; Provisional; Region: PRK05978 1117943002978 ribonuclease R; Region: RNase_R; TIGR02063 1117943002979 RNB domain; Region: RNB; pfam00773 1117943002980 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1117943002981 RNA binding site [nucleotide binding]; other site 1117943002982 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1117943002983 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1117943002984 active site 1117943002985 interdomain interaction site; other site 1117943002986 putative metal-binding site [ion binding]; other site 1117943002987 nucleotide binding site [chemical binding]; other site 1117943002988 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1117943002989 domain I; other site 1117943002990 DNA binding groove [nucleotide binding] 1117943002991 phosphate binding site [ion binding]; other site 1117943002992 domain II; other site 1117943002993 domain III; other site 1117943002994 nucleotide binding site [chemical binding]; other site 1117943002995 catalytic site [active] 1117943002996 domain IV; other site 1117943002997 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1117943002998 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1117943002999 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1117943003000 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1117943003001 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1117943003002 DNA protecting protein DprA; Region: dprA; TIGR00732 1117943003003 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1117943003004 dihydroorotase; Validated; Region: PRK09059 1117943003005 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1117943003006 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1117943003007 active site 1117943003008 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1117943003009 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1117943003010 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1117943003011 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1117943003012 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1117943003013 active site 1117943003014 Predicted permeases [General function prediction only]; Region: COG0679 1117943003015 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 1117943003016 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1117943003017 metal-dependent hydrolase; Provisional; Region: PRK00685 1117943003018 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1117943003019 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1117943003020 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1117943003021 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943003022 Coenzyme A binding pocket [chemical binding]; other site 1117943003023 hypothetical protein; Provisional; Region: PRK13687 1117943003024 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1117943003025 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1117943003026 GatB domain; Region: GatB_Yqey; smart00845 1117943003027 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1117943003028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943003029 Coenzyme A binding pocket [chemical binding]; other site 1117943003030 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1117943003031 putative catalytic residues [active] 1117943003032 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1117943003033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943003034 Coenzyme A binding pocket [chemical binding]; other site 1117943003035 NADH dehydrogenase; Validated; Region: PRK08183 1117943003036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 1117943003037 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1117943003038 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1117943003039 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1117943003040 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1117943003041 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1117943003042 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1117943003043 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1117943003044 carboxyltransferase (CT) interaction site; other site 1117943003045 biotinylation site [posttranslational modification]; other site 1117943003046 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1117943003047 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1117943003048 trimer interface [polypeptide binding]; other site 1117943003049 active site 1117943003050 dimer interface [polypeptide binding]; other site 1117943003051 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1117943003052 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1117943003053 catalytic residues [active] 1117943003054 aspartate aminotransferase; Provisional; Region: PRK05764 1117943003055 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943003056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943003057 homodimer interface [polypeptide binding]; other site 1117943003058 catalytic residue [active] 1117943003059 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1117943003060 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1117943003061 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 1117943003062 AMIN domain; Region: AMIN; pfam11741 1117943003063 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1117943003064 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1117943003065 active site 1117943003066 metal binding site [ion binding]; metal-binding site 1117943003067 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1117943003068 Transglycosylase; Region: Transgly; pfam00912 1117943003069 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1117943003070 peptide chain release factor 2; Provisional; Region: PRK07342 1117943003071 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1117943003072 RF-1 domain; Region: RF-1; pfam00472 1117943003073 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 1117943003074 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1117943003075 LysR family transcriptional regulator; Provisional; Region: PRK14997 1117943003076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943003077 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1117943003078 putative effector binding pocket; other site 1117943003079 putative dimerization interface [polypeptide binding]; other site 1117943003080 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1117943003081 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1117943003082 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1117943003083 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1117943003084 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1117943003085 elongation factor Tu; Reviewed; Region: PRK00049 1117943003086 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1117943003087 G1 box; other site 1117943003088 GEF interaction site [polypeptide binding]; other site 1117943003089 GTP/Mg2+ binding site [chemical binding]; other site 1117943003090 Switch I region; other site 1117943003091 G2 box; other site 1117943003092 G3 box; other site 1117943003093 Switch II region; other site 1117943003094 G4 box; other site 1117943003095 G5 box; other site 1117943003096 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1117943003097 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1117943003098 Antibiotic Binding Site [chemical binding]; other site 1117943003099 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1117943003100 extended (e) SDRs; Region: SDR_e; cd08946 1117943003101 NAD(P) binding site [chemical binding]; other site 1117943003102 active site 1117943003103 substrate binding site [chemical binding]; other site 1117943003104 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1117943003105 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1117943003106 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1117943003107 putative homodimer interface [polypeptide binding]; other site 1117943003108 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1117943003109 heterodimer interface [polypeptide binding]; other site 1117943003110 homodimer interface [polypeptide binding]; other site 1117943003111 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1117943003112 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1117943003113 23S rRNA interface [nucleotide binding]; other site 1117943003114 L7/L12 interface [polypeptide binding]; other site 1117943003115 putative thiostrepton binding site; other site 1117943003116 L25 interface [polypeptide binding]; other site 1117943003117 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1117943003118 mRNA/rRNA interface [nucleotide binding]; other site 1117943003119 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1117943003120 23S rRNA interface [nucleotide binding]; other site 1117943003121 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1117943003122 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1117943003123 core dimer interface [polypeptide binding]; other site 1117943003124 peripheral dimer interface [polypeptide binding]; other site 1117943003125 L10 interface [polypeptide binding]; other site 1117943003126 L11 interface [polypeptide binding]; other site 1117943003127 putative EF-Tu interaction site [polypeptide binding]; other site 1117943003128 putative EF-G interaction site [polypeptide binding]; other site 1117943003129 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1117943003130 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1117943003131 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1117943003132 RPB11 interaction site [polypeptide binding]; other site 1117943003133 RPB12 interaction site [polypeptide binding]; other site 1117943003134 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1117943003135 RPB1 interaction site [polypeptide binding]; other site 1117943003136 RPB11 interaction site [polypeptide binding]; other site 1117943003137 RPB10 interaction site [polypeptide binding]; other site 1117943003138 RPB3 interaction site [polypeptide binding]; other site 1117943003139 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1117943003140 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1117943003141 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1117943003142 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1117943003143 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1117943003144 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1117943003145 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1117943003146 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1117943003147 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1117943003148 DNA binding site [nucleotide binding] 1117943003149 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1117943003150 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1117943003151 S17 interaction site [polypeptide binding]; other site 1117943003152 S8 interaction site; other site 1117943003153 16S rRNA interaction site [nucleotide binding]; other site 1117943003154 streptomycin interaction site [chemical binding]; other site 1117943003155 23S rRNA interaction site [nucleotide binding]; other site 1117943003156 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1117943003157 30S ribosomal protein S7; Validated; Region: PRK05302 1117943003158 elongation factor G; Reviewed; Region: PRK00007 1117943003159 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1117943003160 G1 box; other site 1117943003161 putative GEF interaction site [polypeptide binding]; other site 1117943003162 GTP/Mg2+ binding site [chemical binding]; other site 1117943003163 Switch I region; other site 1117943003164 G2 box; other site 1117943003165 G3 box; other site 1117943003166 Switch II region; other site 1117943003167 G4 box; other site 1117943003168 G5 box; other site 1117943003169 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1117943003170 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1117943003171 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1117943003172 elongation factor Tu; Reviewed; Region: PRK00049 1117943003173 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1117943003174 G1 box; other site 1117943003175 GEF interaction site [polypeptide binding]; other site 1117943003176 GTP/Mg2+ binding site [chemical binding]; other site 1117943003177 Switch I region; other site 1117943003178 G2 box; other site 1117943003179 G3 box; other site 1117943003180 Switch II region; other site 1117943003181 G4 box; other site 1117943003182 G5 box; other site 1117943003183 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1117943003184 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1117943003185 Antibiotic Binding Site [chemical binding]; other site 1117943003186 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1117943003187 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1117943003188 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1117943003189 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1117943003190 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1117943003191 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1117943003192 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1117943003193 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1117943003194 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1117943003195 putative translocon binding site; other site 1117943003196 protein-rRNA interface [nucleotide binding]; other site 1117943003197 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1117943003198 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1117943003199 G-X-X-G motif; other site 1117943003200 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1117943003201 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1117943003202 23S rRNA interface [nucleotide binding]; other site 1117943003203 5S rRNA interface [nucleotide binding]; other site 1117943003204 putative antibiotic binding site [chemical binding]; other site 1117943003205 L25 interface [polypeptide binding]; other site 1117943003206 L27 interface [polypeptide binding]; other site 1117943003207 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1117943003208 23S rRNA interface [nucleotide binding]; other site 1117943003209 putative translocon interaction site; other site 1117943003210 signal recognition particle (SRP54) interaction site; other site 1117943003211 L23 interface [polypeptide binding]; other site 1117943003212 trigger factor interaction site; other site 1117943003213 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1117943003214 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1117943003215 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1117943003216 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1117943003217 RNA binding site [nucleotide binding]; other site 1117943003218 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1117943003219 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1117943003220 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1117943003221 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1117943003222 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1117943003223 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1117943003224 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1117943003225 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1117943003226 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1117943003227 23S rRNA interface [nucleotide binding]; other site 1117943003228 L21e interface [polypeptide binding]; other site 1117943003229 5S rRNA interface [nucleotide binding]; other site 1117943003230 L27 interface [polypeptide binding]; other site 1117943003231 L5 interface [polypeptide binding]; other site 1117943003232 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1117943003233 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1117943003234 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1117943003235 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1117943003236 23S rRNA binding site [nucleotide binding]; other site 1117943003237 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1117943003238 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1117943003239 SecY translocase; Region: SecY; pfam00344 1117943003240 adenylate kinase; Reviewed; Region: adk; PRK00279 1117943003241 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1117943003242 AMP-binding site [chemical binding]; other site 1117943003243 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1117943003244 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1117943003245 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1117943003246 30S ribosomal protein S11; Validated; Region: PRK05309 1117943003247 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1117943003248 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1117943003249 alphaNTD homodimer interface [polypeptide binding]; other site 1117943003250 alphaNTD - beta interaction site [polypeptide binding]; other site 1117943003251 alphaNTD - beta' interaction site [polypeptide binding]; other site 1117943003252 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1117943003253 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1117943003254 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1117943003255 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1117943003256 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1117943003257 Moco binding site; other site 1117943003258 metal coordination site [ion binding]; other site 1117943003259 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1117943003260 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1117943003261 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943003262 protein binding site [polypeptide binding]; other site 1117943003263 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943003264 protein binding site [polypeptide binding]; other site 1117943003265 recombination factor protein RarA; Reviewed; Region: PRK13342 1117943003266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943003267 Walker A motif; other site 1117943003268 ATP binding site [chemical binding]; other site 1117943003269 Walker B motif; other site 1117943003270 arginine finger; other site 1117943003271 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1117943003272 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1117943003273 Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387 1117943003274 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1117943003275 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1117943003276 RNA binding surface [nucleotide binding]; other site 1117943003277 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1117943003278 active site 1117943003279 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 1117943003280 S-formylglutathione hydrolase; Region: PLN02442 1117943003281 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1117943003282 Predicted membrane protein [Function unknown]; Region: COG4291 1117943003283 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1117943003284 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1117943003285 substrate binding site [chemical binding]; other site 1117943003286 catalytic Zn binding site [ion binding]; other site 1117943003287 NAD binding site [chemical binding]; other site 1117943003288 structural Zn binding site [ion binding]; other site 1117943003289 dimer interface [polypeptide binding]; other site 1117943003290 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943003291 non-specific DNA binding site [nucleotide binding]; other site 1117943003292 salt bridge; other site 1117943003293 sequence-specific DNA binding site [nucleotide binding]; other site 1117943003294 EamA-like transporter family; Region: EamA; pfam00892 1117943003295 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1117943003296 lipoate-protein ligase B; Provisional; Region: PRK14341 1117943003297 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 1117943003298 PrkA family serine protein kinase; Provisional; Region: PRK15455 1117943003299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1117943003300 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1117943003301 Uncharacterized conserved protein [Function unknown]; Region: COG2718 1117943003302 SpoVR family protein; Provisional; Region: PRK11767 1117943003303 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1117943003304 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1117943003305 active site 1117943003306 catalytic residues [active] 1117943003307 metal binding site [ion binding]; metal-binding site 1117943003308 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1117943003309 MgtE intracellular N domain; Region: MgtE_N; smart00924 1117943003310 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1117943003311 Divalent cation transporter; Region: MgtE; cl00786 1117943003312 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1117943003313 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1117943003314 DNA binding residues [nucleotide binding] 1117943003315 putative dimer interface [polypeptide binding]; other site 1117943003316 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1117943003317 Predicted membrane protein [Function unknown]; Region: COG3503 1117943003318 Predicted membrane protein [Function unknown]; Region: COG3821 1117943003319 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1117943003320 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1117943003321 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1117943003322 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1117943003323 Uncharacterized conserved protein [Function unknown]; Region: COG5458 1117943003324 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1117943003325 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1117943003326 Sporulation related domain; Region: SPOR; pfam05036 1117943003327 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 1117943003328 PilZ domain; Region: PilZ; pfam07238 1117943003329 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1117943003330 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943003331 cyclase homology domain; Region: CHD; cd07302 1117943003332 nucleotidyl binding site; other site 1117943003333 dimer interface [polypeptide binding]; other site 1117943003334 metal binding site [ion binding]; metal-binding site 1117943003335 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943003336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943003337 TPR motif; other site 1117943003338 binding surface 1117943003339 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943003340 TPR motif; other site 1117943003341 binding surface 1117943003342 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1117943003343 hypothetical protein; Provisional; Region: PRK10279 1117943003344 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1117943003345 nucleophile elbow; other site 1117943003346 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1117943003347 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1117943003348 GTP cyclohydrolase I; Provisional; Region: PLN03044 1117943003349 active site 1117943003350 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1117943003351 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1117943003352 trimerization site [polypeptide binding]; other site 1117943003353 active site 1117943003354 hypothetical protein; Validated; Region: PRK00041 1117943003355 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 1117943003356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1117943003357 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1117943003358 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1117943003359 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1117943003360 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1117943003361 active site 1117943003362 dimer interface [polypeptide binding]; other site 1117943003363 motif 1; other site 1117943003364 motif 2; other site 1117943003365 motif 3; other site 1117943003366 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1117943003367 anticodon binding site; other site 1117943003368 CHASE4 domain; Region: CHASE4; pfam05228 1117943003369 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943003370 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943003371 metal binding site [ion binding]; metal-binding site 1117943003372 active site 1117943003373 I-site; other site 1117943003374 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1117943003375 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 1117943003376 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1117943003377 putative FMN binding site [chemical binding]; other site 1117943003378 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1117943003379 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1117943003380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 1117943003381 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1117943003382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943003383 Coenzyme A binding pocket [chemical binding]; other site 1117943003384 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1117943003385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943003386 Mg2+ binding site [ion binding]; other site 1117943003387 G-X-G motif; other site 1117943003388 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1117943003389 anchoring element; other site 1117943003390 dimer interface [polypeptide binding]; other site 1117943003391 ATP binding site [chemical binding]; other site 1117943003392 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1117943003393 active site 1117943003394 metal binding site [ion binding]; metal-binding site 1117943003395 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1117943003396 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1117943003397 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1117943003398 FAD binding domain; Region: FAD_binding_4; pfam01565 1117943003399 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1117943003400 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1117943003401 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1117943003402 triosephosphate isomerase; Provisional; Region: PRK14565 1117943003403 substrate binding site [chemical binding]; other site 1117943003404 dimer interface [polypeptide binding]; other site 1117943003405 catalytic triad [active] 1117943003406 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1117943003407 CTP synthetase; Validated; Region: pyrG; PRK05380 1117943003408 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1117943003409 Catalytic site [active] 1117943003410 active site 1117943003411 UTP binding site [chemical binding]; other site 1117943003412 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1117943003413 active site 1117943003414 putative oxyanion hole; other site 1117943003415 catalytic triad [active] 1117943003416 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1117943003417 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1117943003418 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1117943003419 enolase; Provisional; Region: eno; PRK00077 1117943003420 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1117943003421 dimer interface [polypeptide binding]; other site 1117943003422 metal binding site [ion binding]; metal-binding site 1117943003423 substrate binding pocket [chemical binding]; other site 1117943003424 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1117943003425 Septum formation initiator; Region: DivIC; pfam04977 1117943003426 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1117943003427 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1117943003428 tetramer interface [polypeptide binding]; other site 1117943003429 TPP-binding site [chemical binding]; other site 1117943003430 heterodimer interface [polypeptide binding]; other site 1117943003431 phosphorylation loop region [posttranslational modification] 1117943003432 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 1117943003433 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1117943003434 E3 interaction surface; other site 1117943003435 lipoyl attachment site [posttranslational modification]; other site 1117943003436 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1117943003437 alpha subunit interface [polypeptide binding]; other site 1117943003438 TPP binding site [chemical binding]; other site 1117943003439 heterodimer interface [polypeptide binding]; other site 1117943003440 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1117943003441 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1117943003442 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1117943003443 E3 interaction surface; other site 1117943003444 lipoyl attachment site [posttranslational modification]; other site 1117943003445 e3 binding domain; Region: E3_binding; pfam02817 1117943003446 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1117943003447 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 1117943003448 active site 1117943003449 catalytic triad [active] 1117943003450 oxyanion hole [active] 1117943003451 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1117943003452 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1117943003453 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1117943003454 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1117943003455 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1117943003456 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1117943003457 Predicted membrane protein [Function unknown]; Region: COG2261 1117943003458 lipoyl synthase; Provisional; Region: PRK05481 1117943003459 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1117943003460 FeS/SAM binding site; other site 1117943003461 topology modulation protein; Reviewed; Region: PRK08118 1117943003462 AAA domain; Region: AAA_17; pfam13207 1117943003463 formate dehydrogenase; Provisional; Region: PRK07574 1117943003464 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 1117943003465 dimerization interface [polypeptide binding]; other site 1117943003466 ligand binding site [chemical binding]; other site 1117943003467 NAD binding site [chemical binding]; other site 1117943003468 catalytic site [active] 1117943003469 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1117943003470 putative coenzyme Q binding site [chemical binding]; other site 1117943003471 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1117943003472 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 1117943003473 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1117943003474 substrate binding site; other site 1117943003475 dimer interface; other site 1117943003476 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1117943003477 homotrimer interaction site [polypeptide binding]; other site 1117943003478 zinc binding site [ion binding]; other site 1117943003479 CDP-binding sites; other site 1117943003480 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1117943003481 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 1117943003482 FMN binding site [chemical binding]; other site 1117943003483 active site 1117943003484 catalytic residues [active] 1117943003485 substrate binding site [chemical binding]; other site 1117943003486 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1117943003487 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1117943003488 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943003489 dimer interface [polypeptide binding]; other site 1117943003490 phosphorylation site [posttranslational modification] 1117943003491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943003492 ATP binding site [chemical binding]; other site 1117943003493 Mg2+ binding site [ion binding]; other site 1117943003494 G-X-G motif; other site 1117943003495 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1117943003496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943003497 active site 1117943003498 phosphorylation site [posttranslational modification] 1117943003499 intermolecular recognition site; other site 1117943003500 dimerization interface [polypeptide binding]; other site 1117943003501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943003502 Walker A motif; other site 1117943003503 ATP binding site [chemical binding]; other site 1117943003504 Walker B motif; other site 1117943003505 arginine finger; other site 1117943003506 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1117943003507 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 1117943003508 HAMP domain; Region: HAMP; pfam00672 1117943003509 dimerization interface [polypeptide binding]; other site 1117943003510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943003511 dimer interface [polypeptide binding]; other site 1117943003512 phosphorylation site [posttranslational modification] 1117943003513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943003514 ATP binding site [chemical binding]; other site 1117943003515 Mg2+ binding site [ion binding]; other site 1117943003516 G-X-G motif; other site 1117943003517 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1117943003518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943003519 active site 1117943003520 phosphorylation site [posttranslational modification] 1117943003521 intermolecular recognition site; other site 1117943003522 dimerization interface [polypeptide binding]; other site 1117943003523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943003524 Walker A motif; other site 1117943003525 ATP binding site [chemical binding]; other site 1117943003526 Walker B motif; other site 1117943003527 arginine finger; other site 1117943003528 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1117943003529 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1117943003530 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1117943003531 homodimer interface [polypeptide binding]; other site 1117943003532 substrate-cofactor binding pocket; other site 1117943003533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943003534 catalytic residue [active] 1117943003535 bacterial Hfq-like; Region: Hfq; cd01716 1117943003536 hexamer interface [polypeptide binding]; other site 1117943003537 Sm1 motif; other site 1117943003538 RNA binding site [nucleotide binding]; other site 1117943003539 Sm2 motif; other site 1117943003540 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1117943003541 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1117943003542 HflX GTPase family; Region: HflX; cd01878 1117943003543 G1 box; other site 1117943003544 GTP/Mg2+ binding site [chemical binding]; other site 1117943003545 Switch I region; other site 1117943003546 G2 box; other site 1117943003547 G3 box; other site 1117943003548 Switch II region; other site 1117943003549 G4 box; other site 1117943003550 G5 box; other site 1117943003551 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1117943003552 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1117943003553 homodimer interface [polypeptide binding]; other site 1117943003554 metal binding site [ion binding]; metal-binding site 1117943003555 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1117943003556 homodimer interface [polypeptide binding]; other site 1117943003557 active site 1117943003558 putative chemical substrate binding site [chemical binding]; other site 1117943003559 metal binding site [ion binding]; metal-binding site 1117943003560 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1117943003561 nucleoside/Zn binding site; other site 1117943003562 dimer interface [polypeptide binding]; other site 1117943003563 catalytic motif [active] 1117943003564 siroheme synthase; Provisional; Region: cysG; PRK10637 1117943003565 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1117943003566 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1117943003567 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1117943003568 active site 1117943003569 SAM binding site [chemical binding]; other site 1117943003570 homodimer interface [polypeptide binding]; other site 1117943003571 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 1117943003572 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1117943003573 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1117943003574 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1117943003575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 1117943003576 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1117943003577 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1117943003578 FAD binding pocket [chemical binding]; other site 1117943003579 FAD binding motif [chemical binding]; other site 1117943003580 phosphate binding motif [ion binding]; other site 1117943003581 beta-alpha-beta structure motif; other site 1117943003582 NAD binding pocket [chemical binding]; other site 1117943003583 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943003584 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943003585 DNA-binding site [nucleotide binding]; DNA binding site 1117943003586 FCD domain; Region: FCD; pfam07729 1117943003587 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1117943003588 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1117943003589 inhibitor site; inhibition site 1117943003590 active site 1117943003591 dimer interface [polypeptide binding]; other site 1117943003592 catalytic residue [active] 1117943003593 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1117943003594 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1117943003595 Walker A/P-loop; other site 1117943003596 ATP binding site [chemical binding]; other site 1117943003597 Q-loop/lid; other site 1117943003598 ABC transporter signature motif; other site 1117943003599 Walker B; other site 1117943003600 D-loop; other site 1117943003601 H-loop/switch region; other site 1117943003602 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1117943003603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943003604 dimer interface [polypeptide binding]; other site 1117943003605 conserved gate region; other site 1117943003606 putative PBP binding loops; other site 1117943003607 ABC-ATPase subunit interface; other site 1117943003608 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1117943003609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1117943003610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943003611 putative PBP binding loops; other site 1117943003612 dimer interface [polypeptide binding]; other site 1117943003613 ABC-ATPase subunit interface; other site 1117943003614 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1117943003615 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943003616 substrate binding pocket [chemical binding]; other site 1117943003617 membrane-bound complex binding site; other site 1117943003618 hinge residues; other site 1117943003619 cystathionine beta-lyase; Provisional; Region: PRK05967 1117943003620 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1117943003621 homodimer interface [polypeptide binding]; other site 1117943003622 substrate-cofactor binding pocket; other site 1117943003623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943003624 catalytic residue [active] 1117943003625 salicylate hydroxylase; Provisional; Region: PRK08163 1117943003626 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1117943003627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 1117943003628 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1117943003629 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1117943003630 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1117943003631 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 1117943003632 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1117943003633 trimer interface [polypeptide binding]; other site 1117943003634 active site 1117943003635 substrate binding site [chemical binding]; other site 1117943003636 CoA binding site [chemical binding]; other site 1117943003637 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 1117943003638 Phasin protein; Region: Phasin_2; pfam09361 1117943003639 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1117943003640 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 1117943003641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943003642 Walker A motif; other site 1117943003643 ATP binding site [chemical binding]; other site 1117943003644 Walker B motif; other site 1117943003645 arginine finger; other site 1117943003646 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943003647 Walker A motif; other site 1117943003648 ATP binding site [chemical binding]; other site 1117943003649 Walker B motif; other site 1117943003650 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1117943003651 AzlC protein; Region: AzlC; pfam03591 1117943003652 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1117943003653 HIT family signature motif; other site 1117943003654 catalytic residue [active] 1117943003655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 1117943003656 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1117943003657 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 1117943003658 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1117943003659 putative active site [active] 1117943003660 catalytic site [active] 1117943003661 putative metal binding site [ion binding]; other site 1117943003662 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1117943003663 homotrimer interaction site [polypeptide binding]; other site 1117943003664 putative active site [active] 1117943003665 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 1117943003666 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1117943003667 rRNA interaction site [nucleotide binding]; other site 1117943003668 S8 interaction site; other site 1117943003669 putative laminin-1 binding site; other site 1117943003670 elongation factor Ts; Provisional; Region: tsf; PRK09377 1117943003671 UBA/TS-N domain; Region: UBA; pfam00627 1117943003672 Elongation factor TS; Region: EF_TS; pfam00889 1117943003673 Elongation factor TS; Region: EF_TS; pfam00889 1117943003674 uridylate kinase; Provisional; Region: pyrH; PRK00358 1117943003675 nucleotide binding site [chemical binding]; other site 1117943003676 substrate binding site [chemical binding]; other site 1117943003677 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1117943003678 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1117943003679 hinge region; other site 1117943003680 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 1117943003681 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1117943003682 catalytic residue [active] 1117943003683 putative FPP diphosphate binding site; other site 1117943003684 putative FPP binding hydrophobic cleft; other site 1117943003685 dimer interface [polypeptide binding]; other site 1117943003686 putative IPP diphosphate binding site; other site 1117943003687 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1117943003688 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1117943003689 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1117943003690 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1117943003691 active site 1117943003692 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1117943003693 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1117943003694 putative substrate binding region [chemical binding]; other site 1117943003695 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1117943003696 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1117943003697 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1117943003698 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1117943003699 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1117943003700 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1117943003701 Surface antigen; Region: Bac_surface_Ag; pfam01103 1117943003702 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1117943003703 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1117943003704 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1117943003705 trimer interface [polypeptide binding]; other site 1117943003706 active site 1117943003707 UDP-GlcNAc binding site [chemical binding]; other site 1117943003708 lipid binding site [chemical binding]; lipid-binding site 1117943003709 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1117943003710 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1117943003711 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1117943003712 active site 1117943003713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494 1117943003714 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1117943003715 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1117943003716 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1117943003717 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1117943003718 dimer interface [polypeptide binding]; other site 1117943003719 active site 1117943003720 citrylCoA binding site [chemical binding]; other site 1117943003721 NADH binding [chemical binding]; other site 1117943003722 cationic pore residues; other site 1117943003723 oxalacetate/citrate binding site [chemical binding]; other site 1117943003724 coenzyme A binding site [chemical binding]; other site 1117943003725 catalytic triad [active] 1117943003726 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1117943003727 Competence protein; Region: Competence; pfam03772 1117943003728 tonB-system energizer ExbB; Region: exbB; TIGR02797 1117943003729 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1117943003730 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1117943003731 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1117943003732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943003733 S-adenosylmethionine binding site [chemical binding]; other site 1117943003734 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1117943003735 Protein of unknown function (DUF2497); Region: DUF2497; cl11534 1117943003736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827 1117943003737 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1117943003738 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1117943003739 HIGH motif; other site 1117943003740 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1117943003741 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1117943003742 active site 1117943003743 KMSKS motif; other site 1117943003744 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1117943003745 tRNA binding surface [nucleotide binding]; other site 1117943003746 anticodon binding site; other site 1117943003747 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1117943003748 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 1117943003749 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1117943003750 Sel1-like repeats; Region: SEL1; smart00671 1117943003751 Sel1-like repeats; Region: SEL1; smart00671 1117943003752 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1117943003753 putative catalytic site [active] 1117943003754 putative phosphate binding site [ion binding]; other site 1117943003755 active site 1117943003756 metal binding site A [ion binding]; metal-binding site 1117943003757 DNA binding site [nucleotide binding] 1117943003758 putative AP binding site [nucleotide binding]; other site 1117943003759 putative metal binding site B [ion binding]; other site 1117943003760 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1117943003761 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 1117943003762 putative active site [active] 1117943003763 catalytic site [active] 1117943003764 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 1117943003765 putative active site [active] 1117943003766 catalytic site [active] 1117943003767 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1117943003768 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1117943003769 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1117943003770 Zn2+ binding site [ion binding]; other site 1117943003771 Mg2+ binding site [ion binding]; other site 1117943003772 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1117943003773 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1117943003774 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1117943003775 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1117943003776 active site 1117943003777 HIGH motif; other site 1117943003778 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1117943003779 KMSK motif region; other site 1117943003780 tRNA binding surface [nucleotide binding]; other site 1117943003781 DALR anticodon binding domain; Region: DALR_1; smart00836 1117943003782 anticodon binding site; other site 1117943003783 Sporulation related domain; Region: SPOR; pfam05036 1117943003784 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1117943003785 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1117943003786 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1117943003787 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1117943003788 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1117943003789 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1117943003790 Walker A/P-loop; other site 1117943003791 ATP binding site [chemical binding]; other site 1117943003792 Q-loop/lid; other site 1117943003793 ABC transporter signature motif; other site 1117943003794 Walker B; other site 1117943003795 D-loop; other site 1117943003796 H-loop/switch region; other site 1117943003797 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 1117943003798 sec-independent translocase; Provisional; Region: PRK00708 1117943003799 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 1117943003800 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1117943003801 seryl-tRNA synthetase; Provisional; Region: PRK05431 1117943003802 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1117943003803 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1117943003804 dimer interface [polypeptide binding]; other site 1117943003805 active site 1117943003806 motif 1; other site 1117943003807 motif 2; other site 1117943003808 motif 3; other site 1117943003809 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1117943003810 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1117943003811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943003812 S-adenosylmethionine binding site [chemical binding]; other site 1117943003813 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1117943003814 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1117943003815 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1117943003816 Peptidase family M23; Region: Peptidase_M23; pfam01551 1117943003817 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1117943003818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943003819 Walker A motif; other site 1117943003820 ATP binding site [chemical binding]; other site 1117943003821 Walker B motif; other site 1117943003822 Preprotein translocase subunit; Region: YajC; pfam02699 1117943003823 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 1117943003824 Protein export membrane protein; Region: SecD_SecF; cl14618 1117943003825 Protein export membrane protein; Region: SecD_SecF; pfam02355 1117943003826 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 1117943003827 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 1117943003828 substrate binding pocket [chemical binding]; other site 1117943003829 substrate-Mg2+ binding site; other site 1117943003830 aspartate-rich region 1; other site 1117943003831 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1117943003832 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943003833 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943003834 dimerization interface [polypeptide binding]; other site 1117943003835 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1117943003836 EamA-like transporter family; Region: EamA; pfam00892 1117943003837 EamA-like transporter family; Region: EamA; pfam00892 1117943003838 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1117943003839 Glucose inhibited division protein A; Region: GIDA; pfam01134 1117943003840 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1117943003841 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1117943003842 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1117943003843 nucleophile elbow; other site 1117943003844 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1117943003845 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1117943003846 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1117943003847 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943003848 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1117943003849 HAMP domain; Region: HAMP; pfam00672 1117943003850 dimerization interface [polypeptide binding]; other site 1117943003851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943003852 dimer interface [polypeptide binding]; other site 1117943003853 phosphorylation site [posttranslational modification] 1117943003854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943003855 ATP binding site [chemical binding]; other site 1117943003856 Mg2+ binding site [ion binding]; other site 1117943003857 G-X-G motif; other site 1117943003858 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1117943003859 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1117943003860 BA14K-like protein; Region: BA14K; pfam07886 1117943003861 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1117943003862 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1117943003863 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1117943003864 Metal-binding active site; metal-binding site 1117943003865 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943003866 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943003867 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1117943003868 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943003869 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943003870 non-specific DNA binding site [nucleotide binding]; other site 1117943003871 salt bridge; other site 1117943003872 sequence-specific DNA binding site [nucleotide binding]; other site 1117943003873 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1117943003874 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1117943003875 PYR/PP interface [polypeptide binding]; other site 1117943003876 dimer interface [polypeptide binding]; other site 1117943003877 TPP binding site [chemical binding]; other site 1117943003878 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1117943003879 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1117943003880 TPP-binding site [chemical binding]; other site 1117943003881 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1117943003882 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1117943003883 NAD binding site [chemical binding]; other site 1117943003884 dimerization interface [polypeptide binding]; other site 1117943003885 product binding site; other site 1117943003886 substrate binding site [chemical binding]; other site 1117943003887 zinc binding site [ion binding]; other site 1117943003888 catalytic residues [active] 1117943003889 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943003890 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943003891 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1117943003892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943003893 dimer interface [polypeptide binding]; other site 1117943003894 conserved gate region; other site 1117943003895 putative PBP binding loops; other site 1117943003896 ABC-ATPase subunit interface; other site 1117943003897 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943003898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943003899 dimer interface [polypeptide binding]; other site 1117943003900 conserved gate region; other site 1117943003901 putative PBP binding loops; other site 1117943003902 ABC-ATPase subunit interface; other site 1117943003903 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1117943003904 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943003905 Walker A/P-loop; other site 1117943003906 ATP binding site [chemical binding]; other site 1117943003907 Q-loop/lid; other site 1117943003908 ABC transporter signature motif; other site 1117943003909 Walker B; other site 1117943003910 D-loop; other site 1117943003911 H-loop/switch region; other site 1117943003912 TOBE domain; Region: TOBE; pfam03459 1117943003913 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1117943003914 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1117943003915 choline dehydrogenase; Validated; Region: PRK02106 1117943003916 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1117943003917 trigger factor; Provisional; Region: tig; PRK01490 1117943003918 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1117943003919 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1117943003920 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1117943003921 Dienelactone hydrolase family; Region: DLH; pfam01738 1117943003922 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1117943003923 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1117943003924 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1117943003925 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1117943003926 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1117943003927 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1117943003928 oligomer interface [polypeptide binding]; other site 1117943003929 metal binding site [ion binding]; metal-binding site 1117943003930 metal binding site [ion binding]; metal-binding site 1117943003931 putative Cl binding site [ion binding]; other site 1117943003932 basic sphincter; other site 1117943003933 hydrophobic gate; other site 1117943003934 periplasmic entrance; other site 1117943003935 hypothetical protein; Reviewed; Region: PRK00024 1117943003936 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1117943003937 MPN+ (JAMM) motif; other site 1117943003938 Zinc-binding site [ion binding]; other site 1117943003939 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1117943003940 active site 1117943003941 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1117943003942 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 1117943003943 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1117943003944 Short C-terminal domain; Region: SHOCT; pfam09851 1117943003945 aminotransferase; Validated; Region: PRK09148 1117943003946 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943003947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943003948 homodimer interface [polypeptide binding]; other site 1117943003949 catalytic residue [active] 1117943003950 homoserine dehydrogenase; Provisional; Region: PRK06349 1117943003951 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1117943003952 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1117943003953 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1117943003954 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1117943003955 DHH family; Region: DHH; pfam01368 1117943003956 DHHA1 domain; Region: DHHA1; pfam02272 1117943003957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1117943003958 Peptidase M15; Region: Peptidase_M15_3; cl01194 1117943003959 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943003960 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1117943003961 dimer interface [polypeptide binding]; other site 1117943003962 active site 1117943003963 metal binding site [ion binding]; metal-binding site 1117943003964 glutathione binding site [chemical binding]; other site 1117943003965 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1117943003966 DNA-binding site [nucleotide binding]; DNA binding site 1117943003967 RNA-binding motif; other site 1117943003968 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1117943003969 DNA-binding site [nucleotide binding]; DNA binding site 1117943003970 RNA-binding motif; other site 1117943003971 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1117943003972 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 1117943003973 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1117943003974 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1117943003975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943003976 Walker A/P-loop; other site 1117943003977 ATP binding site [chemical binding]; other site 1117943003978 Q-loop/lid; other site 1117943003979 ABC transporter signature motif; other site 1117943003980 Walker B; other site 1117943003981 D-loop; other site 1117943003982 H-loop/switch region; other site 1117943003983 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 1117943003984 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1117943003985 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1117943003986 DNA binding residues [nucleotide binding] 1117943003987 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1117943003988 FecR protein; Region: FecR; pfam04773 1117943003989 Secretin and TonB N terminus short domain; Region: STN; smart00965 1117943003990 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1117943003991 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1117943003992 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 1117943003993 IucA / IucC family; Region: IucA_IucC; pfam04183 1117943003994 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1117943003995 acyl-CoA synthetase; Validated; Region: PRK08308 1117943003996 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1117943003997 AMP binding site [chemical binding]; other site 1117943003998 active site 1117943003999 acyl-activating enzyme (AAE) consensus motif; other site 1117943004000 CoA binding site [chemical binding]; other site 1117943004001 acyl carrier protein; Provisional; Region: PRK07639 1117943004002 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1117943004003 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1117943004004 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1117943004005 putative ligand binding residues [chemical binding]; other site 1117943004006 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1117943004007 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1117943004008 ABC-ATPase subunit interface; other site 1117943004009 dimer interface [polypeptide binding]; other site 1117943004010 putative PBP binding regions; other site 1117943004011 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1117943004012 ABC-ATPase subunit interface; other site 1117943004013 dimer interface [polypeptide binding]; other site 1117943004014 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1117943004015 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1117943004016 Walker A/P-loop; other site 1117943004017 ATP binding site [chemical binding]; other site 1117943004018 Q-loop/lid; other site 1117943004019 ABC transporter signature motif; other site 1117943004020 Walker B; other site 1117943004021 D-loop; other site 1117943004022 H-loop/switch region; other site 1117943004023 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1117943004024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943004025 S-adenosylmethionine binding site [chemical binding]; other site 1117943004026 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1117943004027 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1117943004028 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1117943004029 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1117943004030 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1117943004031 conserved cys residue [active] 1117943004032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943004033 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 1117943004034 isocitrate lyase; Provisional; Region: PRK15063 1117943004035 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1117943004036 tetramer interface [polypeptide binding]; other site 1117943004037 active site 1117943004038 Mg2+/Mn2+ binding site [ion binding]; other site 1117943004039 isocitrate lyase; Region: PLN02892 1117943004040 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943004041 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943004042 non-specific DNA binding site [nucleotide binding]; other site 1117943004043 salt bridge; other site 1117943004044 sequence-specific DNA binding site [nucleotide binding]; other site 1117943004045 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1117943004046 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1117943004047 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1117943004048 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1117943004049 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1117943004050 potential frameshift: common BLAST hit: gi|227822001|ref|YP_002825972.1| putative malonate transporter 1117943004051 Predicted permeases [General function prediction only]; Region: COG0679 1117943004052 Membrane transport protein; Region: Mem_trans; cl09117 1117943004053 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 1117943004054 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1117943004055 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1117943004056 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1117943004057 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1117943004058 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1117943004059 NADP binding site [chemical binding]; other site 1117943004060 dimer interface [polypeptide binding]; other site 1117943004061 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1117943004062 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1117943004063 Walker A/P-loop; other site 1117943004064 ATP binding site [chemical binding]; other site 1117943004065 Q-loop/lid; other site 1117943004066 ABC transporter signature motif; other site 1117943004067 Walker B; other site 1117943004068 D-loop; other site 1117943004069 H-loop/switch region; other site 1117943004070 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1117943004071 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943004072 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1117943004073 TM-ABC transporter signature motif; other site 1117943004074 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943004075 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1117943004076 TM-ABC transporter signature motif; other site 1117943004077 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1117943004078 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1117943004079 putative ligand binding site [chemical binding]; other site 1117943004080 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1117943004081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943004082 DNA-binding site [nucleotide binding]; DNA binding site 1117943004083 FCD domain; Region: FCD; pfam07729 1117943004084 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1117943004085 Domain of unknown function DUF21; Region: DUF21; pfam01595 1117943004086 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1117943004087 Transporter associated domain; Region: CorC_HlyC; smart01091 1117943004088 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1117943004089 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1117943004090 dimer interface [polypeptide binding]; other site 1117943004091 putative functional site; other site 1117943004092 putative MPT binding site; other site 1117943004093 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1117943004094 trimer interface [polypeptide binding]; other site 1117943004095 dimer interface [polypeptide binding]; other site 1117943004096 putative active site [active] 1117943004097 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1117943004098 active site 1117943004099 ribulose/triose binding site [chemical binding]; other site 1117943004100 phosphate binding site [ion binding]; other site 1117943004101 substrate (anthranilate) binding pocket [chemical binding]; other site 1117943004102 product (indole) binding pocket [chemical binding]; other site 1117943004103 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1117943004104 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1117943004105 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1117943004106 SurA N-terminal domain; Region: SurA_N_3; cl07813 1117943004107 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1117943004108 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1117943004109 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1117943004110 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1117943004111 PhoU domain; Region: PhoU; pfam01895 1117943004112 PhoU domain; Region: PhoU; pfam01895 1117943004113 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 1117943004114 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1117943004115 Substrate binding site; other site 1117943004116 Mg++ binding site; other site 1117943004117 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1117943004118 active site 1117943004119 substrate binding site [chemical binding]; other site 1117943004120 CoA binding site [chemical binding]; other site 1117943004121 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1117943004122 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1117943004123 glutaminase active site [active] 1117943004124 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1117943004125 dimer interface [polypeptide binding]; other site 1117943004126 active site 1117943004127 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1117943004128 dimer interface [polypeptide binding]; other site 1117943004129 active site 1117943004130 putative acetyltransferase; Provisional; Region: PRK03624 1117943004131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943004132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1117943004133 Coenzyme A binding pocket [chemical binding]; other site 1117943004134 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1117943004135 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1117943004136 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1117943004137 generic binding surface II; other site 1117943004138 ssDNA binding site; other site 1117943004139 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1117943004140 ATP binding site [chemical binding]; other site 1117943004141 putative Mg++ binding site [ion binding]; other site 1117943004142 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1117943004143 nucleotide binding region [chemical binding]; other site 1117943004144 ATP-binding site [chemical binding]; other site 1117943004145 Uncharacterized conserved protein [Function unknown]; Region: COG2938 1117943004146 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1117943004147 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1117943004148 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1117943004149 ATP binding site [chemical binding]; other site 1117943004150 putative Mg++ binding site [ion binding]; other site 1117943004151 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1117943004152 nucleotide binding region [chemical binding]; other site 1117943004153 ATP-binding site [chemical binding]; other site 1117943004154 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1117943004155 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1117943004156 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1117943004157 catalytic residues [active] 1117943004158 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1117943004159 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1117943004160 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 1117943004161 Uncharacterized conserved protein [Function unknown]; Region: COG3785 1117943004162 glutamine synthetase; Provisional; Region: glnA; PRK09469 1117943004163 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1117943004164 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1117943004165 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1117943004166 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1117943004167 putative carbohydrate kinase; Provisional; Region: PRK10565 1117943004168 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1117943004169 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1117943004170 putative substrate binding site [chemical binding]; other site 1117943004171 putative ATP binding site [chemical binding]; other site 1117943004172 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1117943004173 active site 1117943004174 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1117943004175 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1117943004176 putative MPT binding site; other site 1117943004177 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1117943004178 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1117943004179 threonine dehydratase; Validated; Region: PRK08639 1117943004180 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1117943004181 tetramer interface [polypeptide binding]; other site 1117943004182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943004183 catalytic residue [active] 1117943004184 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1117943004185 Transcriptional activator HlyU; Region: HlyU; cl02273 1117943004186 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1117943004187 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1117943004188 active site 1117943004189 metal binding site [ion binding]; metal-binding site 1117943004190 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1117943004191 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943004192 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943004193 metal binding site [ion binding]; metal-binding site 1117943004194 active site 1117943004195 I-site; other site 1117943004196 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943004197 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943004198 putative DNA binding site [nucleotide binding]; other site 1117943004199 putative Zn2+ binding site [ion binding]; other site 1117943004200 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943004201 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1117943004202 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1117943004203 hexamer interface [polypeptide binding]; other site 1117943004204 ligand binding site [chemical binding]; other site 1117943004205 putative active site [active] 1117943004206 NAD(P) binding site [chemical binding]; other site 1117943004207 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 1117943004208 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1117943004209 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1117943004210 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1117943004211 active site residue [active] 1117943004212 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1117943004213 active site residue [active] 1117943004214 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1117943004215 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1117943004216 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1117943004217 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1117943004218 dimer interface [polypeptide binding]; other site 1117943004219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943004220 catalytic residue [active] 1117943004221 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1117943004222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943004223 NAD(P) binding site [chemical binding]; other site 1117943004224 active site 1117943004225 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1117943004226 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1117943004227 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1117943004228 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1117943004229 LexA repressor; Validated; Region: PRK00215 1117943004230 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1117943004231 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1117943004232 Catalytic site [active] 1117943004233 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1117943004234 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 1117943004235 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1117943004236 putative ligand binding site [chemical binding]; other site 1117943004237 putative NAD binding site [chemical binding]; other site 1117943004238 catalytic site [active] 1117943004239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4289 1117943004240 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943004241 DNA binding site [nucleotide binding] 1117943004242 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1117943004243 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1117943004244 ligand binding site [chemical binding]; other site 1117943004245 dimerization interface [polypeptide binding]; other site 1117943004246 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943004247 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943004248 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1117943004249 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1117943004250 Predicted integral membrane protein [Function unknown]; Region: COG5473 1117943004251 PilZ domain; Region: PilZ; pfam07238 1117943004252 adenylosuccinate lyase; Provisional; Region: PRK07492 1117943004253 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1117943004254 tetramer interface [polypeptide binding]; other site 1117943004255 active site 1117943004256 Predicted secreted protein (DUF2259); Region: DUF2259; pfam10016 1117943004257 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1117943004258 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1117943004259 substrate binding site [chemical binding]; other site 1117943004260 hexamer interface [polypeptide binding]; other site 1117943004261 metal binding site [ion binding]; metal-binding site 1117943004262 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1117943004263 putative active site pocket [active] 1117943004264 cleavage site 1117943004265 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 1117943004266 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1117943004267 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1117943004268 ligand binding site [chemical binding]; other site 1117943004269 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1117943004270 MoxR-like ATPases [General function prediction only]; Region: COG0714 1117943004271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943004272 Walker A motif; other site 1117943004273 ATP binding site [chemical binding]; other site 1117943004274 Walker B motif; other site 1117943004275 arginine finger; other site 1117943004276 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1117943004277 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1117943004278 metal ion-dependent adhesion site (MIDAS); other site 1117943004279 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1117943004280 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1117943004281 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1117943004282 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1117943004283 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 1117943004284 putative MPT binding site; other site 1117943004285 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1117943004286 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1117943004287 Ligand binding site; other site 1117943004288 metal-binding site 1117943004289 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1117943004290 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943004291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943004292 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943004293 Helix-turn-helix domain; Region: HTH_28; pfam13518 1117943004294 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943004295 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943004296 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943004297 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943004298 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1117943004299 nudix motif; other site 1117943004300 helicase 45; Provisional; Region: PTZ00424 1117943004301 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1117943004302 ATP binding site [chemical binding]; other site 1117943004303 Mg++ binding site [ion binding]; other site 1117943004304 motif III; other site 1117943004305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1117943004306 nucleotide binding region [chemical binding]; other site 1117943004307 ATP-binding site [chemical binding]; other site 1117943004308 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1117943004309 Peptidase family M23; Region: Peptidase_M23; pfam01551 1117943004310 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1117943004311 dinuclear metal binding motif [ion binding]; other site 1117943004312 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1117943004313 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1117943004314 catalytic triad [active] 1117943004315 Protein of unknown function; Region: DUF3971; pfam13116 1117943004316 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1117943004317 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1117943004318 active site 1117943004319 HIGH motif; other site 1117943004320 dimer interface [polypeptide binding]; other site 1117943004321 KMSKS motif; other site 1117943004322 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1117943004323 RNA binding surface [nucleotide binding]; other site 1117943004324 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943004325 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943004326 metal binding site [ion binding]; metal-binding site 1117943004327 active site 1117943004328 I-site; other site 1117943004329 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1117943004330 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1117943004331 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1117943004332 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1117943004333 catalytic residue [active] 1117943004334 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1117943004335 putative ABC transporter; Region: ycf24; CHL00085 1117943004336 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1117943004337 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1117943004338 Walker A/P-loop; other site 1117943004339 ATP binding site [chemical binding]; other site 1117943004340 Q-loop/lid; other site 1117943004341 ABC transporter signature motif; other site 1117943004342 Walker B; other site 1117943004343 D-loop; other site 1117943004344 H-loop/switch region; other site 1117943004345 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1117943004346 FeS assembly protein SufD; Region: sufD; TIGR01981 1117943004347 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1117943004348 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1117943004349 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1117943004350 catalytic residue [active] 1117943004351 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 1117943004352 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1117943004353 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1117943004354 glycine dehydrogenase; Provisional; Region: PRK05367 1117943004355 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1117943004356 tetramer interface [polypeptide binding]; other site 1117943004357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943004358 catalytic residue [active] 1117943004359 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1117943004360 tetramer interface [polypeptide binding]; other site 1117943004361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943004362 catalytic residue [active] 1117943004363 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1117943004364 lipoyl attachment site [posttranslational modification]; other site 1117943004365 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 1117943004366 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1117943004367 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1117943004368 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 1117943004369 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943004370 Coenzyme A binding pocket [chemical binding]; other site 1117943004371 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 1117943004372 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1117943004373 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1117943004374 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1117943004375 active site 1117943004376 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1117943004377 TSCPD domain; Region: TSCPD; pfam12637 1117943004378 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1117943004379 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1117943004380 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1117943004381 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1117943004382 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1117943004383 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1117943004384 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1117943004385 dimer interface [polypeptide binding]; other site 1117943004386 ssDNA binding site [nucleotide binding]; other site 1117943004387 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1117943004388 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1117943004389 DNA gyrase subunit A; Validated; Region: PRK05560 1117943004390 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1117943004391 CAP-like domain; other site 1117943004392 active site 1117943004393 primary dimer interface [polypeptide binding]; other site 1117943004394 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1117943004395 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1117943004396 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1117943004397 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1117943004398 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1117943004399 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1117943004400 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1117943004401 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1117943004402 catalytic residue [active] 1117943004403 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943004404 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943004405 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1117943004406 putative effector binding pocket; other site 1117943004407 dimerization interface [polypeptide binding]; other site 1117943004408 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1117943004409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1117943004410 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943004411 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943004412 putative DNA binding site [nucleotide binding]; other site 1117943004413 putative Zn2+ binding site [ion binding]; other site 1117943004414 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943004415 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1117943004416 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1117943004417 putative metal binding site; other site 1117943004418 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1117943004419 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1117943004420 putative ADP-binding pocket [chemical binding]; other site 1117943004421 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1117943004422 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1117943004423 putative ADP-binding pocket [chemical binding]; other site 1117943004424 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1117943004425 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1117943004426 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1117943004427 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1117943004428 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1117943004429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943004430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1117943004431 putative substrate translocation pore; other site 1117943004432 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1117943004433 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1117943004434 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1117943004435 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1117943004436 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1117943004437 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1117943004438 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1117943004439 IMP binding site; other site 1117943004440 dimer interface [polypeptide binding]; other site 1117943004441 partial ornithine binding site; other site 1117943004442 Predicted metalloprotease [General function prediction only]; Region: COG2321 1117943004443 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1117943004444 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1117943004445 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1117943004446 active site 1117943004447 catalytic tetrad [active] 1117943004448 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943004449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943004450 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1117943004451 putative effector binding pocket; other site 1117943004452 putative dimerization interface [polypeptide binding]; other site 1117943004453 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1117943004454 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1117943004455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943004456 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1117943004457 putative substrate translocation pore; other site 1117943004458 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1117943004459 cation binding site [ion binding]; other site 1117943004460 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1117943004461 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1117943004462 active site 1117943004463 (T/H)XGH motif; other site 1117943004464 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1117943004465 active site 1117943004466 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1117943004467 active site 1117943004468 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1117943004469 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1117943004470 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1117943004471 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1117943004472 short chain dehydrogenase; Provisional; Region: PRK08703 1117943004473 classical (c) SDRs; Region: SDR_c; cd05233 1117943004474 NAD(P) binding site [chemical binding]; other site 1117943004475 active site 1117943004476 SEC-C motif; Region: SEC-C; pfam02810 1117943004477 2-oxoisovalerate dehydrogenase E2 component; Region: PLN02528 1117943004478 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1117943004479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1117943004480 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1117943004481 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1117943004482 classical (c) SDRs; Region: SDR_c; cd05233 1117943004483 NAD(P) binding site [chemical binding]; other site 1117943004484 active site 1117943004485 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1117943004486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943004487 putative substrate translocation pore; other site 1117943004488 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1117943004489 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943004490 DNA binding site [nucleotide binding] 1117943004491 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943004492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943004493 TPR motif; other site 1117943004494 binding surface 1117943004495 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1117943004496 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943004497 TPR motif; other site 1117943004498 binding surface 1117943004499 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1117943004500 putative hydrolase; Provisional; Region: PRK02113 1117943004501 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1117943004502 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1117943004503 active site 1117943004504 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1117943004505 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1117943004506 active site 1117943004507 HIGH motif; other site 1117943004508 KMSKS motif; other site 1117943004509 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1117943004510 tRNA binding surface [nucleotide binding]; other site 1117943004511 anticodon binding site; other site 1117943004512 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria; Region: NTP-PPase_u1; cd11538 1117943004513 metal binding site [ion binding]; metal-binding site 1117943004514 DNA polymerase III subunit delta'; Validated; Region: PRK09112 1117943004515 AAA ATPase domain; Region: AAA_16; pfam13191 1117943004516 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1117943004517 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1117943004518 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1117943004519 TMP-binding site; other site 1117943004520 ATP-binding site [chemical binding]; other site 1117943004521 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1117943004522 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1117943004523 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1117943004524 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1117943004525 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1117943004526 Hint domain; Region: Hint_2; pfam13403 1117943004527 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943004528 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943004529 non-specific DNA binding site [nucleotide binding]; other site 1117943004530 salt bridge; other site 1117943004531 sequence-specific DNA binding site [nucleotide binding]; other site 1117943004532 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1117943004533 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1117943004534 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1117943004535 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943004536 Integrase core domain; Region: rve; pfam00665 1117943004537 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943004538 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1117943004539 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1117943004540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943004541 Walker A motif; other site 1117943004542 ATP binding site [chemical binding]; other site 1117943004543 Walker B motif; other site 1117943004544 transposase; Validated; Region: PRK08181 1117943004545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943004546 Walker A motif; other site 1117943004547 ATP binding site [chemical binding]; other site 1117943004548 Integrase core domain; Region: rve; pfam00665 1117943004549 Uncharacterized conserved protein [Function unknown]; Region: COG5467 1117943004550 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1117943004551 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1117943004552 ATP binding site [chemical binding]; other site 1117943004553 active site 1117943004554 substrate binding site [chemical binding]; other site 1117943004555 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1117943004556 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1117943004557 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1117943004558 putative active site [active] 1117943004559 catalytic triad [active] 1117943004560 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1117943004561 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943004562 DNA-binding site [nucleotide binding]; DNA binding site 1117943004563 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943004564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943004565 homodimer interface [polypeptide binding]; other site 1117943004566 catalytic residue [active] 1117943004567 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1117943004568 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1117943004569 dimerization interface [polypeptide binding]; other site 1117943004570 ATP binding site [chemical binding]; other site 1117943004571 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1117943004572 dimerization interface [polypeptide binding]; other site 1117943004573 ATP binding site [chemical binding]; other site 1117943004574 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1117943004575 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1117943004576 putative GSH binding site [chemical binding]; other site 1117943004577 catalytic residues [active] 1117943004578 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1117943004579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943004580 putative substrate translocation pore; other site 1117943004581 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1117943004582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943004583 putative substrate translocation pore; other site 1117943004584 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1117943004585 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1117943004586 active site 1117943004587 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1117943004588 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1117943004589 Ligand Binding Site [chemical binding]; other site 1117943004590 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1117943004591 glutaminase; Provisional; Region: PRK00971 1117943004592 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1117943004593 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1117943004594 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1117943004595 RNA binding surface [nucleotide binding]; other site 1117943004596 Domain of unknown function DUF87; Region: DUF87; pfam01935 1117943004597 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1117943004598 glutamate racemase; Provisional; Region: PRK00865 1117943004599 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1117943004600 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1117943004601 isocitrate dehydrogenase; Validated; Region: PRK08299 1117943004602 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 1117943004603 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1117943004604 Helix-turn-helix domain; Region: HTH_18; pfam12833 1117943004605 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943004606 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1117943004607 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1117943004608 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1117943004609 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1117943004610 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1117943004611 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1117943004612 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1117943004613 motif 1; other site 1117943004614 active site 1117943004615 motif 2; other site 1117943004616 motif 3; other site 1117943004617 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1117943004618 recombinase A; Provisional; Region: recA; PRK09354 1117943004619 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1117943004620 hexamer interface [polypeptide binding]; other site 1117943004621 Walker A motif; other site 1117943004622 ATP binding site [chemical binding]; other site 1117943004623 Walker B motif; other site 1117943004624 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1117943004625 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1117943004626 substrate binding site [chemical binding]; other site 1117943004627 ATP binding site [chemical binding]; other site 1117943004628 Uncharacterized enzyme involved in pigment biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IndA; COG2313 1117943004629 PAS domain S-box; Region: sensory_box; TIGR00229 1117943004630 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1117943004631 PAS domain; Region: PAS; smart00091 1117943004632 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943004633 putative active site [active] 1117943004634 heme pocket [chemical binding]; other site 1117943004635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943004636 dimer interface [polypeptide binding]; other site 1117943004637 phosphorylation site [posttranslational modification] 1117943004638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943004639 ATP binding site [chemical binding]; other site 1117943004640 Mg2+ binding site [ion binding]; other site 1117943004641 G-X-G motif; other site 1117943004642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943004643 Response regulator receiver domain; Region: Response_reg; pfam00072 1117943004644 active site 1117943004645 phosphorylation site [posttranslational modification] 1117943004646 intermolecular recognition site; other site 1117943004647 dimerization interface [polypeptide binding]; other site 1117943004648 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1117943004649 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1117943004650 catalytic core [active] 1117943004651 YcjX-like family, DUF463; Region: DUF463; cl01193 1117943004652 Predicted membrane protein [Function unknown]; Region: COG3768 1117943004653 Domain of unknown function (DUF697); Region: DUF697; cl12064 1117943004654 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1117943004655 catalytic center binding site [active] 1117943004656 ATP binding site [chemical binding]; other site 1117943004657 dihydropteroate synthase; Region: DHPS; TIGR01496 1117943004658 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1117943004659 substrate binding pocket [chemical binding]; other site 1117943004660 dimer interface [polypeptide binding]; other site 1117943004661 inhibitor binding site; inhibition site 1117943004662 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5661 1117943004663 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1117943004664 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1117943004665 catalytic loop [active] 1117943004666 iron binding site [ion binding]; other site 1117943004667 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1117943004668 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943004669 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1117943004670 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 1117943004671 cytochrome b; Provisional; Region: CYTB; MTH00191 1117943004672 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1117943004673 Qi binding site; other site 1117943004674 intrachain domain interface; other site 1117943004675 interchain domain interface [polypeptide binding]; other site 1117943004676 heme bH binding site [chemical binding]; other site 1117943004677 heme bL binding site [chemical binding]; other site 1117943004678 Qo binding site; other site 1117943004679 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 1117943004680 interchain domain interface [polypeptide binding]; other site 1117943004681 intrachain domain interface; other site 1117943004682 Qi binding site; other site 1117943004683 Qo binding site; other site 1117943004684 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1117943004685 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1117943004686 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1117943004687 [2Fe-2S] cluster binding site [ion binding]; other site 1117943004688 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1117943004689 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1117943004690 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1117943004691 Walker A/P-loop; other site 1117943004692 ATP binding site [chemical binding]; other site 1117943004693 Q-loop/lid; other site 1117943004694 ABC transporter signature motif; other site 1117943004695 Walker B; other site 1117943004696 D-loop; other site 1117943004697 H-loop/switch region; other site 1117943004698 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1117943004699 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1117943004700 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1117943004701 Walker A/P-loop; other site 1117943004702 ATP binding site [chemical binding]; other site 1117943004703 Q-loop/lid; other site 1117943004704 ABC transporter signature motif; other site 1117943004705 Walker B; other site 1117943004706 D-loop; other site 1117943004707 H-loop/switch region; other site 1117943004708 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1117943004709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943004710 Predicted flavoprotein [General function prediction only]; Region: COG0431 1117943004711 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1117943004712 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1117943004713 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1117943004714 DNA binding residues [nucleotide binding] 1117943004715 dimer interface [polypeptide binding]; other site 1117943004716 [2Fe-2S] cluster binding site [ion binding]; other site 1117943004717 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1117943004718 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 1117943004719 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 1117943004720 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1117943004721 mce related protein; Region: MCE; pfam02470 1117943004722 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1117943004723 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1117943004724 Walker A/P-loop; other site 1117943004725 ATP binding site [chemical binding]; other site 1117943004726 Q-loop/lid; other site 1117943004727 ABC transporter signature motif; other site 1117943004728 Walker B; other site 1117943004729 D-loop; other site 1117943004730 H-loop/switch region; other site 1117943004731 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1117943004732 Permease; Region: Permease; pfam02405 1117943004733 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1117943004734 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1117943004735 active site 1117943004736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943004737 putative substrate translocation pore; other site 1117943004738 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1117943004739 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1117943004740 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1117943004741 putative active site [active] 1117943004742 putative metal binding site [ion binding]; other site 1117943004743 malic enzyme; Reviewed; Region: PRK12862 1117943004744 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1117943004745 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1117943004746 putative NAD(P) binding site [chemical binding]; other site 1117943004747 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1117943004748 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1117943004749 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943004750 DNA binding residues [nucleotide binding] 1117943004751 dimerization interface [polypeptide binding]; other site 1117943004752 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 1117943004753 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 1117943004754 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1117943004755 putative FMN binding site [chemical binding]; other site 1117943004756 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1117943004757 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1117943004758 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1117943004759 NAD synthetase; Provisional; Region: PRK13981 1117943004760 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1117943004761 multimer interface [polypeptide binding]; other site 1117943004762 active site 1117943004763 catalytic triad [active] 1117943004764 protein interface 1 [polypeptide binding]; other site 1117943004765 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1117943004766 homodimer interface [polypeptide binding]; other site 1117943004767 NAD binding pocket [chemical binding]; other site 1117943004768 ATP binding pocket [chemical binding]; other site 1117943004769 Mg binding site [ion binding]; other site 1117943004770 active-site loop [active] 1117943004771 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1117943004772 Sulfatase; Region: Sulfatase; pfam00884 1117943004773 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1117943004774 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1117943004775 glutathione reductase; Validated; Region: PRK06116 1117943004776 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1117943004777 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1117943004778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 1117943004779 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1117943004780 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1117943004781 active site 1117943004782 dimer interface [polypeptide binding]; other site 1117943004783 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1117943004784 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1117943004785 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943004786 motif II; other site 1117943004787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1117943004788 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1117943004789 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1117943004790 Class II fumarases; Region: Fumarase_classII; cd01362 1117943004791 active site 1117943004792 tetramer interface [polypeptide binding]; other site 1117943004793 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943004794 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943004795 metal binding site [ion binding]; metal-binding site 1117943004796 active site 1117943004797 I-site; other site 1117943004798 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 1117943004799 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1117943004800 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1117943004801 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1117943004802 MarR family; Region: MarR_2; pfam12802 1117943004803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 1117943004804 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 1117943004805 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1117943004806 FeS/SAM binding site; other site 1117943004807 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1117943004808 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943004809 dimerization interface [polypeptide binding]; other site 1117943004810 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1117943004811 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1117943004812 dimer interface [polypeptide binding]; other site 1117943004813 putative CheW interface [polypeptide binding]; other site 1117943004814 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1117943004815 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1117943004816 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1117943004817 GTP binding site; other site 1117943004818 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1117943004819 Walker A motif; other site 1117943004820 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1117943004821 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1117943004822 ligand binding site [chemical binding]; other site 1117943004823 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1117943004824 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943004825 substrate binding pocket [chemical binding]; other site 1117943004826 membrane-bound complex binding site; other site 1117943004827 hinge residues; other site 1117943004828 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1117943004829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943004830 dimer interface [polypeptide binding]; other site 1117943004831 conserved gate region; other site 1117943004832 putative PBP binding loops; other site 1117943004833 ABC-ATPase subunit interface; other site 1117943004834 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1117943004835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943004836 dimer interface [polypeptide binding]; other site 1117943004837 conserved gate region; other site 1117943004838 putative PBP binding loops; other site 1117943004839 ABC-ATPase subunit interface; other site 1117943004840 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 1117943004841 Predicted integral membrane protein [Function unknown]; Region: COG5530 1117943004842 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 1117943004843 Tetratricopeptide repeat; Region: TPR_1; pfam00515 1117943004844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943004845 S-adenosylmethionine binding site [chemical binding]; other site 1117943004846 Predicted membrane protein [Function unknown]; Region: COG3174 1117943004847 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 1117943004848 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1117943004849 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1117943004850 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1117943004851 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1117943004852 active site 1117943004853 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943004854 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943004855 putative DNA binding site [nucleotide binding]; other site 1117943004856 putative Zn2+ binding site [ion binding]; other site 1117943004857 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943004858 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1117943004859 putative uracil binding site [chemical binding]; other site 1117943004860 putative active site [active] 1117943004861 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943004862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943004863 dimer interface [polypeptide binding]; other site 1117943004864 phosphorylation site [posttranslational modification] 1117943004865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943004866 ATP binding site [chemical binding]; other site 1117943004867 Mg2+ binding site [ion binding]; other site 1117943004868 G-X-G motif; other site 1117943004869 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1117943004870 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1117943004871 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1117943004872 putative dimer interface [polypeptide binding]; other site 1117943004873 active site pocket [active] 1117943004874 putative cataytic base [active] 1117943004875 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1117943004876 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1117943004877 Predicted aspartyl protease [General function prediction only]; Region: COG3577 1117943004878 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1117943004879 catalytic motif [active] 1117943004880 Catalytic residue [active] 1117943004881 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943004882 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943004883 TM-ABC transporter signature motif; other site 1117943004884 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1117943004885 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1117943004886 Walker A/P-loop; other site 1117943004887 ATP binding site [chemical binding]; other site 1117943004888 Q-loop/lid; other site 1117943004889 ABC transporter signature motif; other site 1117943004890 Walker B; other site 1117943004891 D-loop; other site 1117943004892 H-loop/switch region; other site 1117943004893 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1117943004894 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1117943004895 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1117943004896 ligand binding site [chemical binding]; other site 1117943004897 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1117943004898 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943004899 DNA binding site [nucleotide binding] 1117943004900 domain linker motif; other site 1117943004901 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1117943004902 dimerization interface [polypeptide binding]; other site 1117943004903 ligand binding site [chemical binding]; other site 1117943004904 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1117943004905 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1117943004906 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1117943004907 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1117943004908 Walker A/P-loop; other site 1117943004909 ATP binding site [chemical binding]; other site 1117943004910 Q-loop/lid; other site 1117943004911 ABC transporter signature motif; other site 1117943004912 Walker B; other site 1117943004913 D-loop; other site 1117943004914 H-loop/switch region; other site 1117943004915 Predicted transporter component [General function prediction only]; Region: COG2391 1117943004916 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 1117943004917 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943004918 dimerization interface [polypeptide binding]; other site 1117943004919 putative DNA binding site [nucleotide binding]; other site 1117943004920 putative Zn2+ binding site [ion binding]; other site 1117943004921 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1117943004922 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1117943004923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 1117943004924 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1117943004925 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cd00104 1117943004926 Cache domain; Region: Cache_2; pfam08269 1117943004927 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943004928 dimerization interface [polypeptide binding]; other site 1117943004929 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1117943004930 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1117943004931 dimer interface [polypeptide binding]; other site 1117943004932 putative CheW interface [polypeptide binding]; other site 1117943004933 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1117943004934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3169 1117943004935 excinuclease ABC subunit B; Provisional; Region: PRK05298 1117943004936 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1117943004937 ATP binding site [chemical binding]; other site 1117943004938 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1117943004939 nucleotide binding region [chemical binding]; other site 1117943004940 ATP-binding site [chemical binding]; other site 1117943004941 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1117943004942 UvrB/uvrC motif; Region: UVR; pfam02151 1117943004943 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 1117943004944 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1117943004945 HSP70 interaction site [polypeptide binding]; other site 1117943004946 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1117943004947 DNA-binding site [nucleotide binding]; DNA binding site 1117943004948 RNA-binding motif; other site 1117943004949 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1117943004950 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1117943004951 FMN binding site [chemical binding]; other site 1117943004952 active site 1117943004953 catalytic residues [active] 1117943004954 substrate binding site [chemical binding]; other site 1117943004955 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943004956 active site 1117943004957 DNA binding site [nucleotide binding] 1117943004958 Int/Topo IB signature motif; other site 1117943004959 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1117943004960 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1117943004961 active site 1117943004962 DNA binding site [nucleotide binding] 1117943004963 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1117943004964 DNA binding site [nucleotide binding] 1117943004965 Protein of unknown function (DUF1515); Region: DUF1515; pfam07439 1117943004966 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1117943004967 catalytic residue [active] 1117943004968 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1117943004969 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1117943004970 Phage-related protein [Function unknown]; Region: COG5412 1117943004971 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1117943004972 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 1117943004973 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1117943004974 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 1117943004975 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1117943004976 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1117943004977 oligomerization interface [polypeptide binding]; other site 1117943004978 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1117943004979 Phage capsid family; Region: Phage_capsid; pfam05065 1117943004980 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1117943004981 Phage-related protein [Function unknown]; Region: COG4695 1117943004982 Phage portal protein; Region: Phage_portal; pfam04860 1117943004983 Phage Terminase; Region: Terminase_1; pfam03354 1117943004984 Phage terminase, small subunit; Region: Terminase_4; cl01525 1117943004985 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 1117943004986 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 1117943004987 Helix-turn-helix domain; Region: HTH_36; pfam13730 1117943004988 DNA polymerase III subunit beta; Validated; Region: PRK05643 1117943004989 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 1117943004990 putative DNA binding surface [nucleotide binding]; other site 1117943004991 dimer interface [polypeptide binding]; other site 1117943004992 beta-clamp/clamp loader binding surface; other site 1117943004993 beta-clamp/translesion DNA polymerase binding surface; other site 1117943004994 ParB-like nuclease domain; Region: ParB; smart00470 1117943004995 MT-A70; Region: MT-A70; cl01947 1117943004996 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 1117943004997 ParB-like nuclease domain; Region: ParBc; pfam02195 1117943004998 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943004999 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943005000 non-specific DNA binding site [nucleotide binding]; other site 1117943005001 salt bridge; other site 1117943005002 sequence-specific DNA binding site [nucleotide binding]; other site 1117943005003 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1117943005004 Catalytic site [active] 1117943005005 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 1117943005006 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1117943005007 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1117943005008 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1117943005009 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1117943005010 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1117943005011 trimer interface [polypeptide binding]; other site 1117943005012 putative metal binding site [ion binding]; other site 1117943005013 Phytochelatin synthase; Region: Phytochelatin; pfam05023 1117943005014 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1117943005015 metal binding site 2 [ion binding]; metal-binding site 1117943005016 putative DNA binding helix; other site 1117943005017 metal binding site 1 [ion binding]; metal-binding site 1117943005018 dimer interface [polypeptide binding]; other site 1117943005019 structural Zn2+ binding site [ion binding]; other site 1117943005020 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1117943005021 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1117943005022 ABC-ATPase subunit interface; other site 1117943005023 dimer interface [polypeptide binding]; other site 1117943005024 putative PBP binding regions; other site 1117943005025 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1117943005026 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1117943005027 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 1117943005028 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1117943005029 metal binding site [ion binding]; metal-binding site 1117943005030 Predicted integral membrane protein [Function unknown]; Region: COG5455 1117943005031 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1117943005032 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1117943005033 inhibitor binding site; inhibition site 1117943005034 active site 1117943005035 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 1117943005036 DctM-like transporters; Region: DctM; pfam06808 1117943005037 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1117943005038 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1117943005039 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1117943005040 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1117943005041 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1117943005042 active site 1117943005043 catalytic tetrad [active] 1117943005044 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943005045 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943005046 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1117943005047 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1117943005048 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1117943005049 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1117943005050 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1117943005051 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943005052 Walker A/P-loop; other site 1117943005053 ATP binding site [chemical binding]; other site 1117943005054 Q-loop/lid; other site 1117943005055 ABC transporter signature motif; other site 1117943005056 Walker B; other site 1117943005057 D-loop; other site 1117943005058 H-loop/switch region; other site 1117943005059 TOBE domain; Region: TOBE_2; pfam08402 1117943005060 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943005061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943005062 dimer interface [polypeptide binding]; other site 1117943005063 conserved gate region; other site 1117943005064 putative PBP binding loops; other site 1117943005065 ABC-ATPase subunit interface; other site 1117943005066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943005067 dimer interface [polypeptide binding]; other site 1117943005068 conserved gate region; other site 1117943005069 putative PBP binding loops; other site 1117943005070 ABC-ATPase subunit interface; other site 1117943005071 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943005072 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943005073 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1117943005074 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943005075 DNA binding site [nucleotide binding] 1117943005076 domain linker motif; other site 1117943005077 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1117943005078 ligand binding site [chemical binding]; other site 1117943005079 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943005080 cyclase homology domain; Region: CHD; cd07302 1117943005081 nucleotidyl binding site; other site 1117943005082 metal binding site [ion binding]; metal-binding site 1117943005083 dimer interface [polypeptide binding]; other site 1117943005084 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943005085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943005086 binding surface 1117943005087 TPR motif; other site 1117943005088 TPR repeat; Region: TPR_11; pfam13414 1117943005089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1117943005090 binding surface 1117943005091 TPR motif; other site 1117943005092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1117943005093 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1117943005094 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 1117943005095 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 1117943005096 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1117943005097 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1117943005098 cytochrome oxidase maturation protein, cbb3-type; Region: ccoS; TIGR00847 1117943005099 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1117943005100 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1117943005101 metal-binding site [ion binding] 1117943005102 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943005103 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1117943005104 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 1117943005105 FixH; Region: FixH; pfam05751 1117943005106 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1117943005107 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1117943005108 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1117943005109 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1117943005110 hydrophobic ligand binding site; other site 1117943005111 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943005112 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1117943005113 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1117943005114 Cytochrome c; Region: Cytochrom_C; pfam00034 1117943005115 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1117943005116 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1117943005117 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1117943005118 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 1117943005119 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1117943005120 Low-spin heme binding site [chemical binding]; other site 1117943005121 Putative water exit pathway; other site 1117943005122 Binuclear center (active site) [active] 1117943005123 Putative proton exit pathway; other site 1117943005124 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1117943005125 PAS fold; Region: PAS_4; pfam08448 1117943005126 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1117943005127 putative acyl-acceptor binding pocket; other site 1117943005128 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1117943005129 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1117943005130 NAD(P) binding site [chemical binding]; other site 1117943005131 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 1117943005132 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1117943005133 dimer interface [polypeptide binding]; other site 1117943005134 active site 1117943005135 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 1117943005136 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1117943005137 active site 1117943005138 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 1117943005139 active site 2 [active] 1117943005140 active site 1 [active] 1117943005141 acyl carrier protein; Provisional; Region: PRK06508 1117943005142 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1117943005143 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1117943005144 ligand binding site [chemical binding]; other site 1117943005145 flexible hinge region; other site 1117943005146 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1117943005147 putative switch regulator; other site 1117943005148 non-specific DNA interactions [nucleotide binding]; other site 1117943005149 DNA binding site [nucleotide binding] 1117943005150 sequence specific DNA binding site [nucleotide binding]; other site 1117943005151 putative cAMP binding site [chemical binding]; other site 1117943005152 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1117943005153 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1117943005154 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943005155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943005156 homodimer interface [polypeptide binding]; other site 1117943005157 catalytic residue [active] 1117943005158 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1117943005159 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1117943005160 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1117943005161 active site 1117943005162 SAM binding site [chemical binding]; other site 1117943005163 homodimer interface [polypeptide binding]; other site 1117943005164 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1117943005165 hypothetical protein; Provisional; Region: PRK10621 1117943005166 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1117943005167 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1117943005168 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1117943005169 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1117943005170 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1117943005171 homodimer interface [polypeptide binding]; other site 1117943005172 Walker A motif; other site 1117943005173 ATP binding site [chemical binding]; other site 1117943005174 hydroxycobalamin binding site [chemical binding]; other site 1117943005175 Walker B motif; other site 1117943005176 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1117943005177 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1117943005178 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1117943005179 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1117943005180 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1117943005181 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1117943005182 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1117943005183 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1117943005184 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1117943005185 homotrimer interface [polypeptide binding]; other site 1117943005186 Walker A motif; other site 1117943005187 GTP binding site [chemical binding]; other site 1117943005188 Walker B motif; other site 1117943005189 FecR protein; Region: FecR; pfam04773 1117943005190 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1117943005191 CHASE2 domain; Region: CHASE2; pfam05226 1117943005192 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943005193 cyclase homology domain; Region: CHD; cd07302 1117943005194 nucleotidyl binding site; other site 1117943005195 metal binding site [ion binding]; metal-binding site 1117943005196 dimer interface [polypeptide binding]; other site 1117943005197 cobyric acid synthase; Provisional; Region: PRK00784 1117943005198 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1117943005199 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1117943005200 catalytic triad [active] 1117943005201 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1117943005202 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1117943005203 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1117943005204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943005205 Walker A/P-loop; other site 1117943005206 ATP binding site [chemical binding]; other site 1117943005207 Q-loop/lid; other site 1117943005208 ABC transporter signature motif; other site 1117943005209 Walker B; other site 1117943005210 D-loop; other site 1117943005211 H-loop/switch region; other site 1117943005212 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1117943005213 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1117943005214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943005215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943005216 dimerization interface [polypeptide binding]; other site 1117943005217 methionine synthase I; Validated; Region: PRK07534 1117943005218 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1117943005219 von Willebrand factor; Region: vWF_A; pfam12450 1117943005220 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1117943005221 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1117943005222 metal ion-dependent adhesion site (MIDAS); other site 1117943005223 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1117943005224 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1117943005225 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1117943005226 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1117943005227 DNA binding residues [nucleotide binding] 1117943005228 Predicted periplasmic protein [Function unknown]; Region: COG3698 1117943005229 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1117943005230 Methylmalonic aciduria and homocystinuria type C protein and similar proteins; Region: MMACHC-like; cd12959 1117943005231 cobalamin binding site [chemical binding]; other site 1117943005232 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 1117943005233 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 1117943005234 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 1117943005235 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 1117943005236 B12 binding site [chemical binding]; other site 1117943005237 cobalt ligand [ion binding]; other site 1117943005238 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 1117943005239 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 1117943005240 putative active site [active] 1117943005241 putative cosubstrate binding site; other site 1117943005242 putative substrate binding site [chemical binding]; other site 1117943005243 catalytic site [active] 1117943005244 BA14K-like protein; Region: BA14K; pfam07886 1117943005245 Virulence factor; Region: Virulence_fact; pfam13769 1117943005246 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1117943005247 FAD binding site [chemical binding]; other site 1117943005248 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 1117943005249 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 1117943005250 substrate binding pocket [chemical binding]; other site 1117943005251 dimer interface [polypeptide binding]; other site 1117943005252 inhibitor binding site; inhibition site 1117943005253 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 1117943005254 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1117943005255 catalytic loop [active] 1117943005256 iron binding site [ion binding]; other site 1117943005257 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943005258 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943005259 putative DNA binding site [nucleotide binding]; other site 1117943005260 putative Zn2+ binding site [ion binding]; other site 1117943005261 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943005262 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1117943005263 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1117943005264 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1117943005265 catalytic residue [active] 1117943005266 allantoate amidohydrolase; Reviewed; Region: PRK12890 1117943005267 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1117943005268 active site 1117943005269 metal binding site [ion binding]; metal-binding site 1117943005270 dimer interface [polypeptide binding]; other site 1117943005271 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1117943005272 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1117943005273 metal binding site [ion binding]; metal-binding site 1117943005274 putative dimer interface [polypeptide binding]; other site 1117943005275 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943005276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943005277 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943005278 dimerization interface [polypeptide binding]; other site 1117943005279 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1117943005280 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1117943005281 conserved cys residue [active] 1117943005282 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943005283 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943005284 Response regulator receiver domain; Region: Response_reg; pfam00072 1117943005285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943005286 active site 1117943005287 phosphorylation site [posttranslational modification] 1117943005288 intermolecular recognition site; other site 1117943005289 dimerization interface [polypeptide binding]; other site 1117943005290 transcriptional regulator PhoB; Provisional; Region: PRK10161 1117943005291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943005292 active site 1117943005293 phosphorylation site [posttranslational modification] 1117943005294 intermolecular recognition site; other site 1117943005295 dimerization interface [polypeptide binding]; other site 1117943005296 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943005297 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943005298 metal binding site [ion binding]; metal-binding site 1117943005299 active site 1117943005300 I-site; other site 1117943005301 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1117943005302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1117943005303 active site 1117943005304 phosphorylation site [posttranslational modification] 1117943005305 intermolecular recognition site; other site 1117943005306 dimerization interface [polypeptide binding]; other site 1117943005307 Response regulator receiver domain; Region: Response_reg; pfam00072 1117943005308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943005309 active site 1117943005310 phosphorylation site [posttranslational modification] 1117943005311 intermolecular recognition site; other site 1117943005312 dimerization interface [polypeptide binding]; other site 1117943005313 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943005314 cyclase homology domain; Region: CHD; cd07302 1117943005315 nucleotidyl binding site; other site 1117943005316 metal binding site [ion binding]; metal-binding site 1117943005317 dimer interface [polypeptide binding]; other site 1117943005318 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1117943005319 RibD C-terminal domain; Region: RibD_C; cl17279 1117943005320 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1117943005321 FOG: CBS domain [General function prediction only]; Region: COG0517 1117943005322 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1117943005323 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1117943005324 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1117943005325 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1117943005326 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1117943005327 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1117943005328 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1117943005329 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1117943005330 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1117943005331 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1117943005332 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1117943005333 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1117943005334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 1117943005335 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1117943005336 transmembrane helices; other site 1117943005337 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1117943005338 TrkA-C domain; Region: TrkA_C; pfam02080 1117943005339 TrkA-C domain; Region: TrkA_C; pfam02080 1117943005340 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1117943005341 Protein of unknown function (DUF1515); Region: DUF1515; pfam07439 1117943005342 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1117943005343 catalytic residue [active] 1117943005344 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943005345 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943005346 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943005347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1117943005348 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1117943005349 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1117943005350 active site 1117943005351 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943005352 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943005353 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943005354 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1117943005355 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1117943005356 Terminase-like family; Region: Terminase_6; pfam03237 1117943005357 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 1117943005358 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1117943005359 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 1117943005360 BA14K-like protein; Region: BA14K; pfam07886 1117943005361 BA14K-like protein; Region: BA14K; pfam07886 1117943005362 Transposase domain (DUF772); Region: DUF772; pfam05598 1117943005363 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943005364 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1117943005365 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1117943005366 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1117943005367 DnaA box-binding interface [nucleotide binding]; other site 1117943005368 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1117943005369 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943005370 Integrase core domain; Region: rve; pfam00665 1117943005371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943005372 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1117943005373 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1117943005374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943005375 Walker A motif; other site 1117943005376 ATP binding site [chemical binding]; other site 1117943005377 Walker B motif; other site 1117943005378 Predicted transcriptional regulator [Transcription]; Region: COG2932 1117943005379 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943005380 non-specific DNA binding site [nucleotide binding]; other site 1117943005381 salt bridge; other site 1117943005382 sequence-specific DNA binding site [nucleotide binding]; other site 1117943005383 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1117943005384 Catalytic site [active] 1117943005385 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1117943005386 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1117943005387 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1117943005388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 1117943005389 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 1117943005390 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 1117943005391 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1117943005392 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1117943005393 nudix motif; other site 1117943005394 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1117943005395 putative catalytic site [active] 1117943005396 putative phosphate binding site [ion binding]; other site 1117943005397 putative metal binding site [ion binding]; other site 1117943005398 TIGR02594 family protein; Region: TIGR02594 1117943005399 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 1117943005400 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1117943005401 potential frameshift: common BLAST hit: gi|227822477|ref|YP_002826449.1| hemolysin 1117943005402 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1117943005403 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1117943005404 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1117943005405 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1117943005406 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1117943005407 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1117943005408 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943005409 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943005410 TPR motif; other site 1117943005411 binding surface 1117943005412 TPR repeat; Region: TPR_11; pfam13414 1117943005413 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943005414 TPR motif; other site 1117943005415 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1117943005416 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1117943005417 DNA binding residues [nucleotide binding] 1117943005418 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 1117943005419 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1117943005420 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1117943005421 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 1117943005422 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1117943005423 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1117943005424 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1117943005425 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943005426 cyclase homology domain; Region: CHD; cd07302 1117943005427 nucleotidyl binding site; other site 1117943005428 metal binding site [ion binding]; metal-binding site 1117943005429 dimer interface [polypeptide binding]; other site 1117943005430 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943005431 TPR repeat; Region: TPR_11; pfam13414 1117943005432 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943005433 binding surface 1117943005434 TPR motif; other site 1117943005435 TPR repeat; Region: TPR_11; pfam13414 1117943005436 cell division protein FtsZ; Provisional; Region: PRK13018 1117943005437 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1117943005438 nucleotide binding site [chemical binding]; other site 1117943005439 SulA interaction site; other site 1117943005440 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1117943005441 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943005442 active site 1117943005443 motif I; other site 1117943005444 motif II; other site 1117943005445 AAA ATPase domain; Region: AAA_16; pfam13191 1117943005446 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1117943005447 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 1117943005448 putative C-terminal domain interface [polypeptide binding]; other site 1117943005449 putative GSH binding site (G-site) [chemical binding]; other site 1117943005450 putative dimer interface [polypeptide binding]; other site 1117943005451 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1117943005452 N-terminal domain interface [polypeptide binding]; other site 1117943005453 dimer interface [polypeptide binding]; other site 1117943005454 substrate binding pocket (H-site) [chemical binding]; other site 1117943005455 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1117943005456 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1117943005457 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1117943005458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943005459 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943005460 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943005461 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943005462 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943005463 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943005464 SIR2-like domain; Region: SIR2_2; pfam13289 1117943005465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1117943005466 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943005467 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943005468 Transposase; Region: HTH_Tnp_1; pfam01527 1117943005469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1117943005470 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943005471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943005472 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1117943005473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943005474 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943005475 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943005476 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943005477 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1117943005478 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1117943005479 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1117943005480 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1117943005481 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1117943005482 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943005483 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1117943005484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943005485 S-adenosylmethionine binding site [chemical binding]; other site 1117943005486 short chain dehydrogenase; Provisional; Region: PRK08303 1117943005487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943005488 NAD(P) binding site [chemical binding]; other site 1117943005489 active site 1117943005490 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1117943005491 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1117943005492 C-terminal domain interface [polypeptide binding]; other site 1117943005493 GSH binding site (G-site) [chemical binding]; other site 1117943005494 dimer interface [polypeptide binding]; other site 1117943005495 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1117943005496 N-terminal domain interface [polypeptide binding]; other site 1117943005497 dimer interface [polypeptide binding]; other site 1117943005498 substrate binding pocket (H-site) [chemical binding]; other site 1117943005499 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1117943005500 active site 1117943005501 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1117943005502 catalytic tetrad [active] 1117943005503 SnoaL-like domain; Region: SnoaL_2; pfam12680 1117943005504 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1117943005505 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1117943005506 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943005507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943005508 homodimer interface [polypeptide binding]; other site 1117943005509 catalytic residue [active] 1117943005510 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1117943005511 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1117943005512 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943005513 cyclase homology domain; Region: CHD; cd07302 1117943005514 nucleotidyl binding site; other site 1117943005515 metal binding site [ion binding]; metal-binding site 1117943005516 dimer interface [polypeptide binding]; other site 1117943005517 2TM domain; Region: 2TM; pfam13239 1117943005518 potential frameshift: common BLAST hit: gi|227822515|ref|YP_002826487.1| SAM-dependent methyltransferase 1117943005519 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1117943005520 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1117943005521 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1117943005522 active site 1117943005523 catalytic tetrad [active] 1117943005524 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1117943005525 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1117943005526 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1117943005527 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1117943005528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943005529 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1117943005530 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943005531 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1117943005532 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1117943005533 Walker A/P-loop; other site 1117943005534 ATP binding site [chemical binding]; other site 1117943005535 Q-loop/lid; other site 1117943005536 ABC transporter signature motif; other site 1117943005537 Walker B; other site 1117943005538 D-loop; other site 1117943005539 H-loop/switch region; other site 1117943005540 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1117943005541 FtsX-like permease family; Region: FtsX; pfam02687 1117943005542 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 1117943005543 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 1117943005544 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1117943005545 Catalytic site; other site 1117943005546 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1117943005547 Phosphotransferase enzyme family; Region: APH; pfam01636 1117943005548 putative active site [active] 1117943005549 putative substrate binding site [chemical binding]; other site 1117943005550 ATP binding site [chemical binding]; other site 1117943005551 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1117943005552 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1117943005553 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943005554 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943005555 putative DNA binding site [nucleotide binding]; other site 1117943005556 putative Zn2+ binding site [ion binding]; other site 1117943005557 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943005558 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1117943005559 aspartate racemase; Region: asp_race; TIGR00035 1117943005560 Predicted transcriptional regulators [Transcription]; Region: COG1733 1117943005561 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1117943005562 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1117943005563 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1117943005564 NADP binding site [chemical binding]; other site 1117943005565 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1117943005566 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1117943005567 putative catalytic residue [active] 1117943005568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 1117943005569 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1117943005570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943005571 DNA-binding site [nucleotide binding]; DNA binding site 1117943005572 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943005573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943005574 homodimer interface [polypeptide binding]; other site 1117943005575 catalytic residue [active] 1117943005576 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1117943005577 active site 1117943005578 hydrophilic channel; other site 1117943005579 dimerization interface [polypeptide binding]; other site 1117943005580 catalytic residues [active] 1117943005581 active site lid [active] 1117943005582 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1117943005583 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1117943005584 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1117943005585 DNA binding residues [nucleotide binding] 1117943005586 dimer interface [polypeptide binding]; other site 1117943005587 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1117943005588 DNA binding residues [nucleotide binding] 1117943005589 dimerization interface [polypeptide binding]; other site 1117943005590 EF-hand domain pair; Region: EF_hand_5; pfam13499 1117943005591 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1117943005592 Ca2+ binding site [ion binding]; other site 1117943005593 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 1117943005594 Zn binding site [ion binding]; other site 1117943005595 Uncharacterized conserved protein [Function unknown]; Region: COG3482 1117943005596 Uncharacterized conserved protein [Function unknown]; Region: COG1944 1117943005597 YcaO-like family; Region: YcaO; pfam02624 1117943005598 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1117943005599 cyclase homology domain; Region: CHD; cd07302 1117943005600 nucleotidyl binding site; other site 1117943005601 metal binding site [ion binding]; metal-binding site 1117943005602 dimer interface [polypeptide binding]; other site 1117943005603 Predicted ATPase [General function prediction only]; Region: COG3899 1117943005604 AAA ATPase domain; Region: AAA_16; pfam13191 1117943005605 Predicted ATPase [General function prediction only]; Region: COG3903 1117943005606 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1117943005607 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1117943005608 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1117943005609 putative PBP binding regions; other site 1117943005610 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1117943005611 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 1117943005612 AAA domain; Region: AAA_30; pfam13604 1117943005613 Family description; Region: UvrD_C_2; pfam13538 1117943005614 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1117943005615 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1117943005616 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1117943005617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315 1117943005618 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1117943005619 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1117943005620 RNA polymerase sigma factor; Provisional; Region: PRK12547 1117943005621 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1117943005622 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1117943005623 DNA binding residues [nucleotide binding] 1117943005624 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1117943005625 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 1117943005626 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 1117943005627 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 1117943005628 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 1117943005629 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1117943005630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943005631 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1117943005632 NAD(P) binding site [chemical binding]; other site 1117943005633 active site 1117943005634 DoxX-like family; Region: DoxX_3; pfam13781 1117943005635 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 1117943005636 LysE type translocator; Region: LysE; cl00565 1117943005637 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1117943005638 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1117943005639 active site 1117943005640 catalytic tetrad [active] 1117943005641 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943005642 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1117943005643 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1117943005644 putative valine binding site [chemical binding]; other site 1117943005645 dimer interface [polypeptide binding]; other site 1117943005646 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1117943005647 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 1117943005648 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1117943005649 PYR/PP interface [polypeptide binding]; other site 1117943005650 dimer interface [polypeptide binding]; other site 1117943005651 TPP binding site [chemical binding]; other site 1117943005652 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1117943005653 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1117943005654 TPP-binding site [chemical binding]; other site 1117943005655 dimer interface [polypeptide binding]; other site 1117943005656 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1117943005657 Domain of unknown function DUF87; Region: DUF87; pfam01935 1117943005658 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1117943005659 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1117943005660 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1117943005661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1117943005662 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1117943005663 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1117943005664 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943005665 protein binding site [polypeptide binding]; other site 1117943005666 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943005667 protein binding site [polypeptide binding]; other site 1117943005668 Uncharacterized conserved protein [Function unknown]; Region: COG3603 1117943005669 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1117943005670 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 1117943005671 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1117943005672 FtsH protease regulator HflC; Provisional; Region: PRK11029 1117943005673 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1117943005674 HflK protein; Region: hflK; TIGR01933 1117943005675 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1117943005676 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1117943005677 folate binding site [chemical binding]; other site 1117943005678 NADP+ binding site [chemical binding]; other site 1117943005679 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1117943005680 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1117943005681 putative C-terminal domain interface [polypeptide binding]; other site 1117943005682 putative GSH binding site (G-site) [chemical binding]; other site 1117943005683 putative dimer interface [polypeptide binding]; other site 1117943005684 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1117943005685 N-terminal domain interface [polypeptide binding]; other site 1117943005686 dimer interface [polypeptide binding]; other site 1117943005687 substrate binding pocket (H-site) [chemical binding]; other site 1117943005688 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1117943005689 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1117943005690 dimerization interface [polypeptide binding]; other site 1117943005691 active site 1117943005692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 1117943005693 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 1117943005694 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 1117943005695 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1117943005696 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1117943005697 FAD binding domain; Region: FAD_binding_4; pfam01565 1117943005698 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 1117943005699 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1117943005700 Protein export membrane protein; Region: SecD_SecF; cl14618 1117943005701 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1117943005702 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1117943005703 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943005704 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1117943005705 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1117943005706 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1117943005707 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1117943005708 Part of AAA domain; Region: AAA_19; pfam13245 1117943005709 Family description; Region: UvrD_C_2; pfam13538 1117943005710 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943005711 Coenzyme A binding pocket [chemical binding]; other site 1117943005712 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1117943005713 active site 1117943005714 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943005715 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943005716 metal binding site [ion binding]; metal-binding site 1117943005717 active site 1117943005718 I-site; other site 1117943005719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 1117943005720 CreA protein; Region: CreA; pfam05981 1117943005721 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1117943005722 putative CheA interaction surface; other site 1117943005723 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1117943005724 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1117943005725 dimer interface [polypeptide binding]; other site 1117943005726 putative CheW interface [polypeptide binding]; other site 1117943005727 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1117943005728 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1117943005729 Cu(I) binding site [ion binding]; other site 1117943005730 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 1117943005731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943005732 S-adenosylmethionine binding site [chemical binding]; other site 1117943005733 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1117943005734 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1117943005735 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1117943005736 active site 1117943005737 Predicted membrane protein [Function unknown]; Region: COG4541 1117943005738 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1117943005739 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1117943005740 oligomerization interface [polypeptide binding]; other site 1117943005741 active site 1117943005742 metal binding site [ion binding]; metal-binding site 1117943005743 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1117943005744 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1117943005745 active site 1117943005746 ATP-binding site [chemical binding]; other site 1117943005747 pantoate-binding site; other site 1117943005748 HXXH motif; other site 1117943005749 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1117943005750 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943005751 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1117943005752 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1117943005753 nucleotide binding pocket [chemical binding]; other site 1117943005754 K-X-D-G motif; other site 1117943005755 catalytic site [active] 1117943005756 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1117943005757 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1117943005758 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1117943005759 Dimer interface [polypeptide binding]; other site 1117943005760 BRCT sequence motif; other site 1117943005761 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1117943005762 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1117943005763 Walker A/P-loop; other site 1117943005764 ATP binding site [chemical binding]; other site 1117943005765 Q-loop/lid; other site 1117943005766 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1117943005767 ABC transporter signature motif; other site 1117943005768 Walker B; other site 1117943005769 D-loop; other site 1117943005770 H-loop/switch region; other site 1117943005771 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 1117943005772 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1117943005773 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1117943005774 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1117943005775 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1117943005776 nucleotide binding site [chemical binding]; other site 1117943005777 SulA interaction site; other site 1117943005778 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 1117943005779 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1117943005780 Cell division protein FtsA; Region: FtsA; smart00842 1117943005781 Cell division protein FtsA; Region: FtsA; pfam14450 1117943005782 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1117943005783 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1117943005784 Cell division protein FtsQ; Region: FtsQ; pfam03799 1117943005785 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1117943005786 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1117943005787 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1117943005788 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1117943005789 FAD binding domain; Region: FAD_binding_4; pfam01565 1117943005790 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1117943005791 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1117943005792 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1117943005793 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1117943005794 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1117943005795 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1117943005796 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1117943005797 active site 1117943005798 homodimer interface [polypeptide binding]; other site 1117943005799 cell division protein FtsW; Region: ftsW; TIGR02614 1117943005800 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 1117943005801 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1117943005802 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1117943005803 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1117943005804 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1117943005805 Mg++ binding site [ion binding]; other site 1117943005806 putative catalytic motif [active] 1117943005807 putative substrate binding site [chemical binding]; other site 1117943005808 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 1117943005809 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1117943005810 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1117943005811 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1117943005812 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1117943005813 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1117943005814 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1117943005815 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1117943005816 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1117943005817 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1117943005818 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1117943005819 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 1117943005820 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1117943005821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943005822 S-adenosylmethionine binding site [chemical binding]; other site 1117943005823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1117943005824 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943005825 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1117943005826 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1117943005827 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1117943005828 catalytic residue [active] 1117943005829 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1117943005830 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1117943005831 amidase catalytic site [active] 1117943005832 Zn binding residues [ion binding]; other site 1117943005833 substrate binding site [chemical binding]; other site 1117943005834 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1117943005835 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1117943005836 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1117943005837 putative metal binding site [ion binding]; other site 1117943005838 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1117943005839 HSP70 interaction site [polypeptide binding]; other site 1117943005840 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 1117943005841 6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205 1117943005842 active site 1117943005843 ADP/pyrophosphate binding site [chemical binding]; other site 1117943005844 dimerization interface [polypeptide binding]; other site 1117943005845 allosteric effector site; other site 1117943005846 fructose-1,6-bisphosphate binding site; other site 1117943005847 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1117943005848 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1117943005849 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1117943005850 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1117943005851 catalytic residue [active] 1117943005852 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1117943005853 Beta-lactamase; Region: Beta-lactamase; pfam00144 1117943005854 S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase [Lipid metabolism]; Region: BtaA; COG5379 1117943005855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943005856 S-adenosylmethionine binding site [chemical binding]; other site 1117943005857 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 1117943005858 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 1117943005859 active site 1117943005860 lytic murein transglycosylase; Region: MltB_2; TIGR02283 1117943005861 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1117943005862 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1117943005863 EamA-like transporter family; Region: EamA; pfam00892 1117943005864 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1117943005865 EamA-like transporter family; Region: EamA; pfam00892 1117943005866 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1117943005867 FAD binding site [chemical binding]; other site 1117943005868 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943005869 dimerization interface [polypeptide binding]; other site 1117943005870 putative DNA binding site [nucleotide binding]; other site 1117943005871 putative Zn2+ binding site [ion binding]; other site 1117943005872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943005873 S-adenosylmethionine binding site [chemical binding]; other site 1117943005874 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1117943005875 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943005876 Walker A/P-loop; other site 1117943005877 ATP binding site [chemical binding]; other site 1117943005878 Q-loop/lid; other site 1117943005879 ABC transporter signature motif; other site 1117943005880 Walker B; other site 1117943005881 D-loop; other site 1117943005882 H-loop/switch region; other site 1117943005883 ABC transporter; Region: ABC_tran_2; pfam12848 1117943005884 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1117943005885 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1117943005886 B1 nucleotide binding pocket [chemical binding]; other site 1117943005887 B2 nucleotide binding pocket [chemical binding]; other site 1117943005888 CAS motifs; other site 1117943005889 active site 1117943005890 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1117943005891 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1117943005892 thiamine pyrophosphate protein; Validated; Region: PRK08199 1117943005893 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1117943005894 PYR/PP interface [polypeptide binding]; other site 1117943005895 dimer interface [polypeptide binding]; other site 1117943005896 TPP binding site [chemical binding]; other site 1117943005897 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1117943005898 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1117943005899 TPP-binding site [chemical binding]; other site 1117943005900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453 1117943005901 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1117943005902 active site 1117943005903 catalytic residues [active] 1117943005904 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1117943005905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1117943005906 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1117943005907 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1117943005908 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943005909 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1117943005910 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1117943005911 Magnesium ion binding site [ion binding]; other site 1117943005912 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1117943005913 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 1117943005914 putative active site [active] 1117943005915 metal binding site [ion binding]; metal-binding site 1117943005916 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1117943005917 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 1117943005918 NAD(P) binding site [chemical binding]; other site 1117943005919 catalytic residues [active] 1117943005920 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1117943005921 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1117943005922 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1117943005923 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 1117943005924 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 1117943005925 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1117943005926 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1117943005927 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1117943005928 putative active site [active] 1117943005929 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1117943005930 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1117943005931 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1117943005932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943005933 putative PBP binding loops; other site 1117943005934 dimer interface [polypeptide binding]; other site 1117943005935 ABC-ATPase subunit interface; other site 1117943005936 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1117943005937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943005938 dimer interface [polypeptide binding]; other site 1117943005939 conserved gate region; other site 1117943005940 putative PBP binding loops; other site 1117943005941 ABC-ATPase subunit interface; other site 1117943005942 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1117943005943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943005944 Walker A/P-loop; other site 1117943005945 ATP binding site [chemical binding]; other site 1117943005946 Q-loop/lid; other site 1117943005947 ABC transporter signature motif; other site 1117943005948 Walker B; other site 1117943005949 D-loop; other site 1117943005950 H-loop/switch region; other site 1117943005951 TOBE domain; Region: TOBE_2; pfam08402 1117943005952 riboflavin synthase subunit beta; Provisional; Region: PRK12419 1117943005953 active site 1117943005954 homopentamer interface [polypeptide binding]; other site 1117943005955 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1117943005956 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1117943005957 conserved cys residue [active] 1117943005958 Uncharacterized conserved protein [Function unknown]; Region: COG3246 1117943005959 bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531 1117943005960 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1117943005961 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1117943005962 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1117943005963 active site 1117943005964 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1117943005965 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1117943005966 active site 1117943005967 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1117943005968 CoA binding domain; Region: CoA_binding_2; pfam13380 1117943005969 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1117943005970 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1117943005971 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 1117943005972 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1117943005973 substrate binding site [chemical binding]; other site 1117943005974 oxyanion hole (OAH) forming residues; other site 1117943005975 trimer interface [polypeptide binding]; other site 1117943005976 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1117943005977 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1117943005978 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1117943005979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943005980 dimer interface [polypeptide binding]; other site 1117943005981 conserved gate region; other site 1117943005982 ABC-ATPase subunit interface; other site 1117943005983 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1117943005984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943005985 dimer interface [polypeptide binding]; other site 1117943005986 conserved gate region; other site 1117943005987 ABC-ATPase subunit interface; other site 1117943005988 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1117943005989 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943005990 Walker A/P-loop; other site 1117943005991 ATP binding site [chemical binding]; other site 1117943005992 Q-loop/lid; other site 1117943005993 ABC transporter signature motif; other site 1117943005994 Walker B; other site 1117943005995 D-loop; other site 1117943005996 H-loop/switch region; other site 1117943005997 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1117943005998 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943005999 Walker A/P-loop; other site 1117943006000 ATP binding site [chemical binding]; other site 1117943006001 Q-loop/lid; other site 1117943006002 ABC transporter signature motif; other site 1117943006003 Walker B; other site 1117943006004 D-loop; other site 1117943006005 H-loop/switch region; other site 1117943006006 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1117943006007 Predicted acyl esterases [General function prediction only]; Region: COG2936 1117943006008 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1117943006009 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1117943006010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 1117943006011 ACT domain; Region: ACT_3; pfam10000 1117943006012 Family description; Region: ACT_7; pfam13840 1117943006013 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1117943006014 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943006015 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943006016 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1117943006017 putative substrate binding pocket [chemical binding]; other site 1117943006018 dimerization interface [polypeptide binding]; other site 1117943006019 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1117943006020 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1117943006021 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1117943006022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943006023 Walker A/P-loop; other site 1117943006024 ATP binding site [chemical binding]; other site 1117943006025 Q-loop/lid; other site 1117943006026 ABC transporter signature motif; other site 1117943006027 Walker B; other site 1117943006028 D-loop; other site 1117943006029 H-loop/switch region; other site 1117943006030 TOBE domain; Region: TOBE_2; pfam08402 1117943006031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943006032 putative PBP binding loops; other site 1117943006033 dimer interface [polypeptide binding]; other site 1117943006034 ABC-ATPase subunit interface; other site 1117943006035 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1117943006036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943006037 dimer interface [polypeptide binding]; other site 1117943006038 conserved gate region; other site 1117943006039 putative PBP binding loops; other site 1117943006040 ABC-ATPase subunit interface; other site 1117943006041 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1117943006042 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1117943006043 tetrameric interface [polypeptide binding]; other site 1117943006044 NAD binding site [chemical binding]; other site 1117943006045 catalytic residues [active] 1117943006046 substrate binding site [chemical binding]; other site 1117943006047 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 1117943006048 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1117943006049 N-terminal plug; other site 1117943006050 ligand-binding site [chemical binding]; other site 1117943006051 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1117943006052 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1117943006053 intersubunit interface [polypeptide binding]; other site 1117943006054 Isochorismatase family; Region: Isochorismatase; pfam00857 1117943006055 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1117943006056 catalytic triad [active] 1117943006057 conserved cis-peptide bond; other site 1117943006058 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943006059 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1117943006060 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943006061 Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598 1117943006062 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943006063 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1117943006064 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1117943006065 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1117943006066 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1117943006067 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943006068 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1117943006069 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1117943006070 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1117943006071 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943006072 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943006073 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1117943006074 dimerization interface [polypeptide binding]; other site 1117943006075 Predicted membrane protein [Function unknown]; Region: COG4425 1117943006076 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1117943006077 Phospholipid methyltransferase; Region: PEMT; cl17370 1117943006078 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943006079 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943006080 putative DNA binding site [nucleotide binding]; other site 1117943006081 putative Zn2+ binding site [ion binding]; other site 1117943006082 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943006083 methionine gamma-lyase; Validated; Region: PRK07049 1117943006084 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1117943006085 homodimer interface [polypeptide binding]; other site 1117943006086 substrate-cofactor binding pocket; other site 1117943006087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943006088 catalytic residue [active] 1117943006089 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 1117943006090 dimer interface [polypeptide binding]; other site 1117943006091 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943006092 Predicted integral membrane protein [Function unknown]; Region: COG5500 1117943006093 cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459 1117943006094 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 1117943006095 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1117943006096 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1117943006097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 1117943006098 Putative glucoamylase; Region: Glycoamylase; pfam10091 1117943006099 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1117943006100 metal ion-dependent adhesion site (MIDAS); other site 1117943006101 Uncharacterized conserved protein [Function unknown]; Region: COG1944 1117943006102 YcaO-like family; Region: YcaO; pfam02624 1117943006103 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1117943006104 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943006105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943006106 TPR motif; other site 1117943006107 TPR repeat; Region: TPR_11; pfam13414 1117943006108 binding surface 1117943006109 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943006110 binding surface 1117943006111 TPR motif; other site 1117943006112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1117943006113 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1117943006114 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1117943006115 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1117943006116 4Fe-4S binding domain; Region: Fer4; pfam00037 1117943006117 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1117943006118 FOG: CBS domain [General function prediction only]; Region: COG0517 1117943006119 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1117943006120 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1117943006121 catalytic loop [active] 1117943006122 iron binding site [ion binding]; other site 1117943006123 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1117943006124 4Fe-4S binding domain; Region: Fer4; pfam00037 1117943006125 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1117943006126 [4Fe-4S] binding site [ion binding]; other site 1117943006127 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 1117943006128 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1117943006129 SLBB domain; Region: SLBB; pfam10531 1117943006130 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1117943006131 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1117943006132 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1117943006133 putative dimer interface [polypeptide binding]; other site 1117943006134 [2Fe-2S] cluster binding site [ion binding]; other site 1117943006135 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1117943006136 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1117943006137 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1117943006138 NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838 1117943006139 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1117943006140 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1117943006141 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 1117943006142 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1117943006143 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 1117943006144 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1117943006145 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1117943006146 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1117943006147 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1117943006148 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1117943006149 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1117943006150 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943006151 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943006152 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1117943006153 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1117943006154 active site 1117943006155 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1117943006156 catalytic tetrad [active] 1117943006157 potential frameshift: common BLAST hit: gi|227822763|ref|YP_002826735.1| AraC family transcriptional regulator 1117943006158 Cupin domain; Region: Cupin_2; pfam07883 1117943006159 Helix-turn-helix domain; Region: HTH_18; pfam12833 1117943006160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943006161 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1117943006162 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1117943006163 conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096 1117943006164 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1117943006165 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 1117943006166 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1117943006167 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1117943006168 catalytic residue [active] 1117943006169 Uncharacterized conserved protein [Function unknown]; Region: COG4274 1117943006170 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1117943006171 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1117943006172 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1117943006173 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1117943006174 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1117943006175 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1117943006176 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1117943006177 DNA binding residues [nucleotide binding] 1117943006178 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1117943006179 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1117943006180 NAD(P) binding site [chemical binding]; other site 1117943006181 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1117943006182 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1117943006183 substrate-cofactor binding pocket; other site 1117943006184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943006185 catalytic residue [active] 1117943006186 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 1117943006187 GIY-YIG motif/motif A; other site 1117943006188 putative active site [active] 1117943006189 putative metal binding site [ion binding]; other site 1117943006190 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1117943006191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1117943006192 ATP binding site [chemical binding]; other site 1117943006193 putative Mg++ binding site [ion binding]; other site 1117943006194 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1117943006195 nucleotide binding region [chemical binding]; other site 1117943006196 ATP-binding site [chemical binding]; other site 1117943006197 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1117943006198 HRDC domain; Region: HRDC; pfam00570 1117943006199 DNA primase; Validated; Region: dnaG; PRK05667 1117943006200 CHC2 zinc finger; Region: zf-CHC2; cl17510 1117943006201 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1117943006202 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1117943006203 active site 1117943006204 metal binding site [ion binding]; metal-binding site 1117943006205 interdomain interaction site; other site 1117943006206 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1117943006207 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1117943006208 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1117943006209 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1117943006210 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1117943006211 catalytic site [active] 1117943006212 subunit interface [polypeptide binding]; other site 1117943006213 LysR family transcriptional regulator; Provisional; Region: PRK14997 1117943006214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943006215 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1117943006216 putative effector binding pocket; other site 1117943006217 dimerization interface [polypeptide binding]; other site 1117943006218 short chain dehydrogenase; Provisional; Region: PRK06500 1117943006219 classical (c) SDRs; Region: SDR_c; cd05233 1117943006220 NAD(P) binding site [chemical binding]; other site 1117943006221 active site 1117943006222 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1117943006223 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1117943006224 aspartate aminotransferase; Provisional; Region: PRK05764 1117943006225 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943006226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943006227 homodimer interface [polypeptide binding]; other site 1117943006228 catalytic residue [active] 1117943006229 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1117943006230 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1117943006231 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1117943006232 EamA-like transporter family; Region: EamA; pfam00892 1117943006233 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1117943006234 DNA-binding site [nucleotide binding]; DNA binding site 1117943006235 RNA-binding motif; other site 1117943006236 BA14K-like protein; Region: BA14K; pfam07886 1117943006237 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1117943006238 Bacterial SH3 domain; Region: SH3_3; pfam08239 1117943006239 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 1117943006240 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1117943006241 MarR family; Region: MarR_2; pfam12802 1117943006242 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1117943006243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943006244 active site 1117943006245 phosphorylation site [posttranslational modification] 1117943006246 intermolecular recognition site; other site 1117943006247 dimerization interface [polypeptide binding]; other site 1117943006248 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943006249 DNA binding site [nucleotide binding] 1117943006250 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943006251 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1117943006252 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1117943006253 dimer interface [polypeptide binding]; other site 1117943006254 phosphorylation site [posttranslational modification] 1117943006255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943006256 ATP binding site [chemical binding]; other site 1117943006257 Mg2+ binding site [ion binding]; other site 1117943006258 G-X-G motif; other site 1117943006259 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 1117943006260 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1117943006261 dimer interface [polypeptide binding]; other site 1117943006262 putative tRNA-binding site [nucleotide binding]; other site 1117943006263 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943006264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943006265 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1117943006266 putative effector binding pocket; other site 1117943006267 dimerization interface [polypeptide binding]; other site 1117943006268 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1117943006269 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1117943006270 Uncharacterized conserved protein [Function unknown]; Region: COG5465 1117943006271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1117943006272 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1117943006273 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1117943006274 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1117943006275 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1117943006276 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1117943006277 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1117943006278 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1117943006279 active site 1117943006280 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1117943006281 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1117943006282 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1117943006283 active site 1117943006284 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1117943006285 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1117943006286 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943006287 cyclase homology domain; Region: CHD; cd07302 1117943006288 nucleotidyl binding site; other site 1117943006289 metal binding site [ion binding]; metal-binding site 1117943006290 dimer interface [polypeptide binding]; other site 1117943006291 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943006292 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943006293 TPR motif; other site 1117943006294 binding surface 1117943006295 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1117943006296 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1117943006297 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1117943006298 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1117943006299 Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782 1117943006300 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1117943006301 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1117943006302 active site 1117943006303 phosphorylation site [posttranslational modification] 1117943006304 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 1117943006305 oligomer interface [polypeptide binding]; other site 1117943006306 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1117943006307 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1117943006308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943006309 Walker A motif; other site 1117943006310 ATP binding site [chemical binding]; other site 1117943006311 Walker B motif; other site 1117943006312 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1117943006313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943006314 Integrase core domain; Region: rve; pfam00665 1117943006315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943006316 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1117943006317 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1117943006318 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1117943006319 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943006320 dimer interface [polypeptide binding]; other site 1117943006321 phosphorylation site [posttranslational modification] 1117943006322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943006323 ATP binding site [chemical binding]; other site 1117943006324 Mg2+ binding site [ion binding]; other site 1117943006325 G-X-G motif; other site 1117943006326 transcriptional regulator HdfR; Provisional; Region: PRK03601 1117943006327 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943006328 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1117943006329 dimerization interface [polypeptide binding]; other site 1117943006330 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1117943006331 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1117943006332 active site 1117943006333 intersubunit interactions; other site 1117943006334 catalytic residue [active] 1117943006335 AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478 1117943006336 [2Fe-2S] cluster binding site [ion binding]; other site 1117943006337 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1117943006338 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1117943006339 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1117943006340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 1117943006341 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1117943006342 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1117943006343 NAD(P) binding site [chemical binding]; other site 1117943006344 catalytic residues [active] 1117943006345 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1117943006346 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1117943006347 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943006348 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1117943006349 Bacterial transcriptional regulator; Region: IclR; pfam01614 1117943006350 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1117943006351 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1117943006352 benzoate transporter; Region: benE; TIGR00843 1117943006353 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1117943006354 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1117943006355 5S rRNA interface [nucleotide binding]; other site 1117943006356 CTC domain interface [polypeptide binding]; other site 1117943006357 L16 interface [polypeptide binding]; other site 1117943006358 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943006359 dimerization interface [polypeptide binding]; other site 1117943006360 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943006361 PAS domain; Region: PAS_9; pfam13426 1117943006362 putative active site [active] 1117943006363 heme pocket [chemical binding]; other site 1117943006364 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943006365 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943006366 metal binding site [ion binding]; metal-binding site 1117943006367 active site 1117943006368 I-site; other site 1117943006369 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1117943006370 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943006371 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1117943006372 substrate binding pocket [chemical binding]; other site 1117943006373 membrane-bound complex binding site; other site 1117943006374 hinge residues; other site 1117943006375 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1117943006376 putative active site [active] 1117943006377 catalytic residue [active] 1117943006378 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1117943006379 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1117943006380 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1117943006381 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1117943006382 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943006383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943006384 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1117943006385 substrate binding pocket [chemical binding]; other site 1117943006386 dimerization interface [polypeptide binding]; other site 1117943006387 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 1117943006388 GTP-binding protein YchF; Reviewed; Region: PRK09601 1117943006389 YchF GTPase; Region: YchF; cd01900 1117943006390 G1 box; other site 1117943006391 GTP/Mg2+ binding site [chemical binding]; other site 1117943006392 Switch I region; other site 1117943006393 G2 box; other site 1117943006394 Switch II region; other site 1117943006395 G3 box; other site 1117943006396 G4 box; other site 1117943006397 G5 box; other site 1117943006398 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1117943006399 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1117943006400 putative active site [active] 1117943006401 putative catalytic site [active] 1117943006402 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1117943006403 putative active site [active] 1117943006404 putative catalytic site [active] 1117943006405 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1117943006406 active site 1117943006407 Predicted small metal-binding protein [Function unknown]; Region: COG5466 1117943006408 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1117943006409 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1117943006410 active site 1117943006411 NTP binding site [chemical binding]; other site 1117943006412 metal binding triad [ion binding]; metal-binding site 1117943006413 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1117943006414 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1117943006415 putative active site [active] 1117943006416 putative CoA binding site [chemical binding]; other site 1117943006417 nudix motif; other site 1117943006418 metal binding site [ion binding]; metal-binding site 1117943006419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 1117943006420 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 1117943006421 MoxR-like ATPases [General function prediction only]; Region: COG0714 1117943006422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943006423 Walker A motif; other site 1117943006424 ATP binding site [chemical binding]; other site 1117943006425 Walker B motif; other site 1117943006426 arginine finger; other site 1117943006427 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1117943006428 Protein of unknown function DUF58; Region: DUF58; pfam01882 1117943006429 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 1117943006430 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1117943006431 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 1117943006432 CARDB; Region: CARDB; pfam07705 1117943006433 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 1117943006434 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1117943006435 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943006436 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1117943006437 Coenzyme A binding pocket [chemical binding]; other site 1117943006438 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1117943006439 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1117943006440 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1117943006441 putative dimer interface [polypeptide binding]; other site 1117943006442 N-terminal domain interface [polypeptide binding]; other site 1117943006443 putative substrate binding pocket (H-site) [chemical binding]; other site 1117943006444 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 1117943006445 nudix motif; other site 1117943006446 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1117943006447 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 1117943006448 putative active site [active] 1117943006449 putative metal binding site [ion binding]; other site 1117943006450 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1117943006451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943006452 binding surface 1117943006453 TPR motif; other site 1117943006454 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1117943006455 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1117943006456 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1117943006457 DNA binding residues [nucleotide binding] 1117943006458 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1117943006459 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943006460 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943006461 2-isopropylmalate synthase; Validated; Region: PRK03739 1117943006462 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1117943006463 active site 1117943006464 catalytic residues [active] 1117943006465 metal binding site [ion binding]; metal-binding site 1117943006466 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1117943006467 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1117943006468 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1117943006469 oligomer interface [polypeptide binding]; other site 1117943006470 active site residues [active] 1117943006471 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1117943006472 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1117943006473 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1117943006474 Cation efflux family; Region: Cation_efflux; cl00316 1117943006475 anthranilate synthase; Provisional; Region: PRK13566 1117943006476 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1117943006477 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1117943006478 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1117943006479 glutamine binding [chemical binding]; other site 1117943006480 catalytic triad [active] 1117943006481 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1117943006482 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1117943006483 N-terminal plug; other site 1117943006484 ligand-binding site [chemical binding]; other site 1117943006485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 1117943006486 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1117943006487 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1117943006488 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 1117943006489 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1117943006490 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1117943006491 Potassium binding sites [ion binding]; other site 1117943006492 Cesium cation binding sites [ion binding]; other site 1117943006493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345 1117943006494 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1117943006495 putative active site [active] 1117943006496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1117943006497 thymidine kinase; Provisional; Region: PRK04296 1117943006498 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1117943006499 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1117943006500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943006501 dimer interface [polypeptide binding]; other site 1117943006502 conserved gate region; other site 1117943006503 putative PBP binding loops; other site 1117943006504 ABC-ATPase subunit interface; other site 1117943006505 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 1117943006506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943006507 Walker A/P-loop; other site 1117943006508 ATP binding site [chemical binding]; other site 1117943006509 Q-loop/lid; other site 1117943006510 ABC transporter signature motif; other site 1117943006511 Walker B; other site 1117943006512 D-loop; other site 1117943006513 H-loop/switch region; other site 1117943006514 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1117943006515 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 1117943006516 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 1117943006517 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1117943006518 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943006519 dimerization interface [polypeptide binding]; other site 1117943006520 putative DNA binding site [nucleotide binding]; other site 1117943006521 putative Zn2+ binding site [ion binding]; other site 1117943006522 omega amino acid--pyruvate transaminase; Provisional; Region: PRK13360 1117943006523 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1117943006524 inhibitor-cofactor binding pocket; inhibition site 1117943006525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943006526 catalytic residue [active] 1117943006527 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1117943006528 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1117943006529 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1117943006530 active site 1117943006531 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1117943006532 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 1117943006533 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1117943006534 active site 1117943006535 catalytic site [active] 1117943006536 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1117943006537 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1117943006538 substrate binding site [chemical binding]; other site 1117943006539 ATP binding site [chemical binding]; other site 1117943006540 GTP-binding protein Der; Reviewed; Region: PRK00093 1117943006541 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1117943006542 G1 box; other site 1117943006543 GTP/Mg2+ binding site [chemical binding]; other site 1117943006544 Switch I region; other site 1117943006545 G2 box; other site 1117943006546 Switch II region; other site 1117943006547 G3 box; other site 1117943006548 G4 box; other site 1117943006549 G5 box; other site 1117943006550 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1117943006551 G1 box; other site 1117943006552 GTP/Mg2+ binding site [chemical binding]; other site 1117943006553 Switch I region; other site 1117943006554 G2 box; other site 1117943006555 G3 box; other site 1117943006556 Switch II region; other site 1117943006557 G4 box; other site 1117943006558 G5 box; other site 1117943006559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 1117943006560 NnrU protein; Region: NnrU; cl17713 1117943006561 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 1117943006562 NodB motif; other site 1117943006563 putative active site [active] 1117943006564 putative catalytic site [active] 1117943006565 microcin B17 transporter; Reviewed; Region: PRK11098 1117943006566 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1117943006567 POT family; Region: PTR2; cl17359 1117943006568 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1117943006569 active site 1117943006570 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1117943006571 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1117943006572 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943006573 dimerization interface [polypeptide binding]; other site 1117943006574 putative DNA binding site [nucleotide binding]; other site 1117943006575 putative Zn2+ binding site [ion binding]; other site 1117943006576 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1117943006577 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1117943006578 N- and C-terminal domain interface [polypeptide binding]; other site 1117943006579 active site 1117943006580 MgATP binding site [chemical binding]; other site 1117943006581 catalytic site [active] 1117943006582 metal binding site [ion binding]; metal-binding site 1117943006583 glycerol binding site [chemical binding]; other site 1117943006584 homotetramer interface [polypeptide binding]; other site 1117943006585 homodimer interface [polypeptide binding]; other site 1117943006586 FBP binding site [chemical binding]; other site 1117943006587 protein IIAGlc interface [polypeptide binding]; other site 1117943006588 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 1117943006589 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1117943006590 catalytic loop [active] 1117943006591 iron binding site [ion binding]; other site 1117943006592 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1117943006593 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1117943006594 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 1117943006595 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1117943006596 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1117943006597 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1117943006598 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943006599 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1117943006600 dimerization interface [polypeptide binding]; other site 1117943006601 substrate binding pocket [chemical binding]; other site 1117943006602 Predicted membrane protein [Function unknown]; Region: COG3748 1117943006603 Protein of unknown function (DUF989); Region: DUF989; pfam06181 1117943006604 Cytochrome c; Region: Cytochrom_C; pfam00034 1117943006605 guanine deaminase; Provisional; Region: PRK09228 1117943006606 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1117943006607 active site 1117943006608 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1117943006609 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1117943006610 phosphate binding site [ion binding]; other site 1117943006611 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1117943006612 active site 1117943006613 homotetramer interface [polypeptide binding]; other site 1117943006614 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1117943006615 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1117943006616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 1117943006617 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1117943006618 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1117943006619 active site 1117943006620 catalytic site [active] 1117943006621 tetramer interface [polypeptide binding]; other site 1117943006622 Protein of unknown function (DUF1045); Region: DUF1045; pfam06299 1117943006623 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943006624 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1117943006625 Protein required for attachment to host cells; Region: Host_attach; cl02398 1117943006626 helicase 45; Provisional; Region: PTZ00424 1117943006627 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1117943006628 ATP binding site [chemical binding]; other site 1117943006629 Mg++ binding site [ion binding]; other site 1117943006630 motif III; other site 1117943006631 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1117943006632 nucleotide binding region [chemical binding]; other site 1117943006633 ATP-binding site [chemical binding]; other site 1117943006634 Isochorismatase family; Region: Isochorismatase; pfam00857 1117943006635 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1117943006636 catalytic triad [active] 1117943006637 conserved cis-peptide bond; other site 1117943006638 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1117943006639 EamA-like transporter family; Region: EamA; pfam00892 1117943006640 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1117943006641 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1117943006642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1117943006643 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1117943006644 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1117943006645 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1117943006646 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1117943006647 dihydroxy-acid dehydratase; Validated; Region: PRK06131 1117943006648 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1117943006649 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1117943006650 NAD(P) binding site [chemical binding]; other site 1117943006651 catalytic residues [active] 1117943006652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 1117943006653 Adenylosuccinate lyase C-terminus; Region: ADSL_C; cl17237 1117943006654 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1117943006655 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943006656 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943006657 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943006658 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943006659 TM-ABC transporter signature motif; other site 1117943006660 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1117943006661 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1117943006662 Walker A/P-loop; other site 1117943006663 ATP binding site [chemical binding]; other site 1117943006664 Q-loop/lid; other site 1117943006665 ABC transporter signature motif; other site 1117943006666 Walker B; other site 1117943006667 D-loop; other site 1117943006668 H-loop/switch region; other site 1117943006669 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1117943006670 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1117943006671 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1117943006672 putative ligand binding site [chemical binding]; other site 1117943006673 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1117943006674 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943006675 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943006676 dimerization interface [polypeptide binding]; other site 1117943006677 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943006678 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943006679 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1117943006680 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1117943006681 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1117943006682 PAS domain S-box; Region: sensory_box; TIGR00229 1117943006683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1117943006684 putative active site [active] 1117943006685 heme pocket [chemical binding]; other site 1117943006686 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943006687 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943006688 metal binding site [ion binding]; metal-binding site 1117943006689 active site 1117943006690 I-site; other site 1117943006691 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1117943006692 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1117943006693 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1117943006694 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1117943006695 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1117943006696 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1117943006697 putative ligand binding site [chemical binding]; other site 1117943006698 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1117943006699 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943006700 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943006701 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943006702 TM-ABC transporter signature motif; other site 1117943006703 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1117943006704 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1117943006705 Walker A/P-loop; other site 1117943006706 ATP binding site [chemical binding]; other site 1117943006707 Q-loop/lid; other site 1117943006708 ABC transporter signature motif; other site 1117943006709 Walker B; other site 1117943006710 D-loop; other site 1117943006711 H-loop/switch region; other site 1117943006712 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 1117943006713 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1117943006714 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943006715 cyclase homology domain; Region: CHD; cd07302 1117943006716 nucleotidyl binding site; other site 1117943006717 metal binding site [ion binding]; metal-binding site 1117943006718 dimer interface [polypeptide binding]; other site 1117943006719 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1117943006720 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1117943006721 Ca2+ binding site [ion binding]; other site 1117943006722 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1117943006723 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1117943006724 catalytic residue [active] 1117943006725 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1117943006726 FAD binding domain; Region: FAD_binding_4; pfam01565 1117943006727 Berberine and berberine like; Region: BBE; pfam08031 1117943006728 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1117943006729 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1117943006730 substrate binding site; other site 1117943006731 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1117943006732 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1117943006733 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1117943006734 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1117943006735 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 1117943006736 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1117943006737 extended (e) SDRs; Region: SDR_e; cd08946 1117943006738 NAD(P) binding site [chemical binding]; other site 1117943006739 substrate binding site [chemical binding]; other site 1117943006740 active site 1117943006741 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1117943006742 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1117943006743 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943006744 Walker A/P-loop; other site 1117943006745 ATP binding site [chemical binding]; other site 1117943006746 Q-loop/lid; other site 1117943006747 ABC transporter signature motif; other site 1117943006748 Walker B; other site 1117943006749 D-loop; other site 1117943006750 H-loop/switch region; other site 1117943006751 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1117943006752 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943006753 Walker A/P-loop; other site 1117943006754 ATP binding site [chemical binding]; other site 1117943006755 Q-loop/lid; other site 1117943006756 ABC transporter signature motif; other site 1117943006757 Walker B; other site 1117943006758 D-loop; other site 1117943006759 H-loop/switch region; other site 1117943006760 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1117943006761 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1117943006762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943006763 ABC-ATPase subunit interface; other site 1117943006764 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1117943006765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943006766 dimer interface [polypeptide binding]; other site 1117943006767 conserved gate region; other site 1117943006768 putative PBP binding loops; other site 1117943006769 ABC-ATPase subunit interface; other site 1117943006770 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1117943006771 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1117943006772 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1117943006773 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1117943006774 active site 1117943006775 dimer interface [polypeptide binding]; other site 1117943006776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 1117943006777 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1117943006778 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1117943006779 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943006780 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1117943006781 apolar tunnel; other site 1117943006782 heme binding site [chemical binding]; other site 1117943006783 dimerization interface [polypeptide binding]; other site 1117943006784 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1117943006785 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1117943006786 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1117943006787 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1117943006788 Hemin uptake protein hemP; Region: hemP; pfam10636 1117943006789 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1117943006790 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1117943006791 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1117943006792 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1117943006793 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 1117943006794 putative hemin binding site; other site 1117943006795 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1117943006796 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1117943006797 ABC-ATPase subunit interface; other site 1117943006798 dimer interface [polypeptide binding]; other site 1117943006799 putative PBP binding regions; other site 1117943006800 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1117943006801 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1117943006802 Walker A/P-loop; other site 1117943006803 ATP binding site [chemical binding]; other site 1117943006804 Q-loop/lid; other site 1117943006805 ABC transporter signature motif; other site 1117943006806 Walker B; other site 1117943006807 D-loop; other site 1117943006808 H-loop/switch region; other site 1117943006809 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1117943006810 GAF domain; Region: GAF; pfam01590 1117943006811 PAS domain; Region: PAS; smart00091 1117943006812 PAS fold; Region: PAS; pfam00989 1117943006813 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1117943006814 HWE histidine kinase; Region: HWE_HK; pfam07536 1117943006815 RNA polymerase sigma factor; Provisional; Region: PRK12516 1117943006816 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1117943006817 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1117943006818 DNA binding residues [nucleotide binding] 1117943006819 two-component response regulator; Provisional; Region: PRK09191 1117943006820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943006821 active site 1117943006822 phosphorylation site [posttranslational modification] 1117943006823 intermolecular recognition site; other site 1117943006824 dimerization interface [polypeptide binding]; other site 1117943006825 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 1117943006826 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 1117943006827 N- and C-terminal domain interface [polypeptide binding]; other site 1117943006828 active site 1117943006829 MgATP binding site [chemical binding]; other site 1117943006830 catalytic site [active] 1117943006831 metal binding site [ion binding]; metal-binding site 1117943006832 carbohydrate binding site [chemical binding]; other site 1117943006833 putative homodimer interface [polypeptide binding]; other site 1117943006834 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1117943006835 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943006836 motif II; other site 1117943006837 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1117943006838 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1117943006839 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1117943006840 sorbitol dehydrogenase; Provisional; Region: PRK07067 1117943006841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943006842 NAD(P) binding site [chemical binding]; other site 1117943006843 active site 1117943006844 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1117943006845 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943006846 Walker A/P-loop; other site 1117943006847 ATP binding site [chemical binding]; other site 1117943006848 Q-loop/lid; other site 1117943006849 ABC transporter signature motif; other site 1117943006850 Walker B; other site 1117943006851 D-loop; other site 1117943006852 H-loop/switch region; other site 1117943006853 TOBE domain; Region: TOBE_2; pfam08402 1117943006854 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943006855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943006856 dimer interface [polypeptide binding]; other site 1117943006857 conserved gate region; other site 1117943006858 putative PBP binding loops; other site 1117943006859 ABC-ATPase subunit interface; other site 1117943006860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943006861 dimer interface [polypeptide binding]; other site 1117943006862 conserved gate region; other site 1117943006863 putative PBP binding loops; other site 1117943006864 ABC-ATPase subunit interface; other site 1117943006865 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943006866 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943006867 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1117943006868 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1117943006869 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1117943006870 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1117943006871 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1117943006872 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1117943006873 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1117943006874 homodimer interface [polypeptide binding]; other site 1117943006875 active site 1117943006876 FMN binding site [chemical binding]; other site 1117943006877 substrate binding site [chemical binding]; other site 1117943006878 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1117943006879 4Fe-4S binding domain; Region: Fer4; pfam00037 1117943006880 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1117943006881 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1117943006882 putative NAD(P) binding site [chemical binding]; other site 1117943006883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943006884 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943006885 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943006886 dimerization interface [polypeptide binding]; other site 1117943006887 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1117943006888 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1117943006889 catalytic loop [active] 1117943006890 iron binding site [ion binding]; other site 1117943006891 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943006892 cyclase homology domain; Region: CHD; cd07302 1117943006893 nucleotidyl binding site; other site 1117943006894 metal binding site [ion binding]; metal-binding site 1117943006895 dimer interface [polypeptide binding]; other site 1117943006896 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1117943006897 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943006898 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1117943006899 allantoate amidohydrolase; Reviewed; Region: PRK12893 1117943006900 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1117943006901 active site 1117943006902 metal binding site [ion binding]; metal-binding site 1117943006903 dimer interface [polypeptide binding]; other site 1117943006904 phenylhydantoinase; Validated; Region: PRK08323 1117943006905 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1117943006906 tetramer interface [polypeptide binding]; other site 1117943006907 active site 1117943006908 Predicted mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: COG4101 1117943006909 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1117943006910 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1117943006911 Walker A/P-loop; other site 1117943006912 ATP binding site [chemical binding]; other site 1117943006913 Q-loop/lid; other site 1117943006914 ABC transporter signature motif; other site 1117943006915 Walker B; other site 1117943006916 D-loop; other site 1117943006917 H-loop/switch region; other site 1117943006918 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1117943006919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943006920 dimer interface [polypeptide binding]; other site 1117943006921 conserved gate region; other site 1117943006922 putative PBP binding loops; other site 1117943006923 ABC-ATPase subunit interface; other site 1117943006924 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1117943006925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943006926 dimer interface [polypeptide binding]; other site 1117943006927 conserved gate region; other site 1117943006928 putative PBP binding loops; other site 1117943006929 ABC-ATPase subunit interface; other site 1117943006930 NMT1/THI5 like; Region: NMT1; pfam09084 1117943006931 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1117943006932 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1117943006933 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1117943006934 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943006935 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1117943006936 Protein export membrane protein; Region: SecD_SecF; cl14618 1117943006937 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1117943006938 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1117943006939 ligand binding site [chemical binding]; other site 1117943006940 flexible hinge region; other site 1117943006941 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1117943006942 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1117943006943 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1117943006944 UreF; Region: UreF; pfam01730 1117943006945 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 1117943006946 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1117943006947 dimer interface [polypeptide binding]; other site 1117943006948 catalytic residues [active] 1117943006949 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1117943006950 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1117943006951 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1117943006952 catalytic triad [active] 1117943006953 dimer interface [polypeptide binding]; other site 1117943006954 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1117943006955 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1117943006956 subunit interactions [polypeptide binding]; other site 1117943006957 active site 1117943006958 flap region; other site 1117943006959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1117943006960 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1117943006961 gamma-beta subunit interface [polypeptide binding]; other site 1117943006962 alpha-beta subunit interface [polypeptide binding]; other site 1117943006963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 1117943006964 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 1117943006965 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1117943006966 alpha-gamma subunit interface [polypeptide binding]; other site 1117943006967 beta-gamma subunit interface [polypeptide binding]; other site 1117943006968 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1117943006969 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1117943006970 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1117943006971 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1117943006972 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1117943006973 MarR family; Region: MarR; pfam01047 1117943006974 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 1117943006975 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1117943006976 dimer interface [polypeptide binding]; other site 1117943006977 active site 1117943006978 CoA binding pocket [chemical binding]; other site 1117943006979 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1117943006980 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1117943006981 inhibitor-cofactor binding pocket; inhibition site 1117943006982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943006983 catalytic residue [active] 1117943006984 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1117943006985 AAA domain; Region: AAA_26; pfam13500 1117943006986 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1117943006987 hypothetical protein; Provisional; Region: PRK07505 1117943006988 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1117943006989 catalytic residue [active] 1117943006990 biotin synthase; Region: bioB; TIGR00433 1117943006991 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1117943006992 FeS/SAM binding site; other site 1117943006993 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1117943006994 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1117943006995 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1117943006996 dimerization interface [polypeptide binding]; other site 1117943006997 ligand binding site [chemical binding]; other site 1117943006998 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1117943006999 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1117943007000 Walker A/P-loop; other site 1117943007001 ATP binding site [chemical binding]; other site 1117943007002 Q-loop/lid; other site 1117943007003 ABC transporter signature motif; other site 1117943007004 Walker B; other site 1117943007005 D-loop; other site 1117943007006 H-loop/switch region; other site 1117943007007 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1117943007008 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1117943007009 Walker A/P-loop; other site 1117943007010 ATP binding site [chemical binding]; other site 1117943007011 Q-loop/lid; other site 1117943007012 ABC transporter signature motif; other site 1117943007013 Walker B; other site 1117943007014 D-loop; other site 1117943007015 H-loop/switch region; other site 1117943007016 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1117943007017 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1117943007018 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1117943007019 TM-ABC transporter signature motif; other site 1117943007020 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943007021 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1117943007022 TM-ABC transporter signature motif; other site 1117943007023 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1117943007024 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1117943007025 active site 1117943007026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943007027 active site 1117943007028 phosphorylation site [posttranslational modification] 1117943007029 intermolecular recognition site; other site 1117943007030 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1117943007031 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1117943007032 ligand binding site [chemical binding]; other site 1117943007033 flexible hinge region; other site 1117943007034 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1117943007035 putative switch regulator; other site 1117943007036 non-specific DNA interactions [nucleotide binding]; other site 1117943007037 DNA binding site [nucleotide binding] 1117943007038 sequence specific DNA binding site [nucleotide binding]; other site 1117943007039 putative cAMP binding site [chemical binding]; other site 1117943007040 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1117943007041 classical (c) SDRs; Region: SDR_c; cd05233 1117943007042 NAD(P) binding site [chemical binding]; other site 1117943007043 active site 1117943007044 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1117943007045 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943007046 Zn binding site [ion binding]; other site 1117943007047 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1117943007048 Zn binding site [ion binding]; other site 1117943007049 Predicted esterase [General function prediction only]; Region: COG0400 1117943007050 putative hydrolase; Provisional; Region: PRK11460 1117943007051 VCBS repeat; Region: VCBS_repeat; TIGR01965 1117943007052 VCBS repeat; Region: VCBS_repeat; TIGR01965 1117943007053 VCBS repeat; Region: VCBS_repeat; TIGR01965 1117943007054 VCBS repeat; Region: VCBS_repeat; TIGR01965 1117943007055 Cadherin repeat-like domain; Region: CA_like; cl15786 1117943007056 Ca2+ binding site [ion binding]; other site 1117943007057 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1117943007058 Predicted flavoprotein [General function prediction only]; Region: COG0431 1117943007059 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1117943007060 Zn binding site [ion binding]; other site 1117943007061 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1117943007062 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943007063 Zn binding site [ion binding]; other site 1117943007064 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1117943007065 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 1117943007066 putative active site [active] 1117943007067 catalytic triad [active] 1117943007068 putative dimer interface [polypeptide binding]; other site 1117943007069 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1117943007070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943007071 dimer interface [polypeptide binding]; other site 1117943007072 conserved gate region; other site 1117943007073 putative PBP binding loops; other site 1117943007074 ABC-ATPase subunit interface; other site 1117943007075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943007076 dimer interface [polypeptide binding]; other site 1117943007077 conserved gate region; other site 1117943007078 putative PBP binding loops; other site 1117943007079 ABC-ATPase subunit interface; other site 1117943007080 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1117943007081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943007082 Walker A/P-loop; other site 1117943007083 ATP binding site [chemical binding]; other site 1117943007084 Q-loop/lid; other site 1117943007085 ABC transporter signature motif; other site 1117943007086 Walker B; other site 1117943007087 D-loop; other site 1117943007088 H-loop/switch region; other site 1117943007089 TOBE domain; Region: TOBE_2; pfam08402 1117943007090 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1117943007091 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1117943007092 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 1117943007093 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1117943007094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943007095 putative PBP binding loops; other site 1117943007096 dimer interface [polypeptide binding]; other site 1117943007097 ABC-ATPase subunit interface; other site 1117943007098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943007099 dimer interface [polypeptide binding]; other site 1117943007100 conserved gate region; other site 1117943007101 putative PBP binding loops; other site 1117943007102 ABC-ATPase subunit interface; other site 1117943007103 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1117943007104 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943007105 substrate binding pocket [chemical binding]; other site 1117943007106 membrane-bound complex binding site; other site 1117943007107 hinge residues; other site 1117943007108 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1117943007109 agmatinase; Region: agmatinase; TIGR01230 1117943007110 oligomer interface [polypeptide binding]; other site 1117943007111 putative active site [active] 1117943007112 Mn binding site [ion binding]; other site 1117943007113 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1117943007114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943007115 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1117943007116 dimerization interface [polypeptide binding]; other site 1117943007117 substrate binding pocket [chemical binding]; other site 1117943007118 hypothetical protein; Provisional; Region: PRK07550 1117943007119 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943007120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943007121 homodimer interface [polypeptide binding]; other site 1117943007122 catalytic residue [active] 1117943007123 EamA-like transporter family; Region: EamA; pfam00892 1117943007124 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1117943007125 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1117943007126 NAD binding site [chemical binding]; other site 1117943007127 catalytic residues [active] 1117943007128 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1117943007129 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1117943007130 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1117943007131 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943007132 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1117943007133 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943007134 DNA-binding site [nucleotide binding]; DNA binding site 1117943007135 FCD domain; Region: FCD; pfam07729 1117943007136 hypothetical protein; Provisional; Region: PRK05968 1117943007137 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1117943007138 homodimer interface [polypeptide binding]; other site 1117943007139 substrate-cofactor binding pocket; other site 1117943007140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943007141 catalytic residue [active] 1117943007142 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943007143 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943007144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943007145 dimer interface [polypeptide binding]; other site 1117943007146 conserved gate region; other site 1117943007147 putative PBP binding loops; other site 1117943007148 ABC-ATPase subunit interface; other site 1117943007149 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943007150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943007151 dimer interface [polypeptide binding]; other site 1117943007152 conserved gate region; other site 1117943007153 putative PBP binding loops; other site 1117943007154 ABC-ATPase subunit interface; other site 1117943007155 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1117943007156 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943007157 Walker A/P-loop; other site 1117943007158 ATP binding site [chemical binding]; other site 1117943007159 Q-loop/lid; other site 1117943007160 ABC transporter signature motif; other site 1117943007161 Walker B; other site 1117943007162 D-loop; other site 1117943007163 H-loop/switch region; other site 1117943007164 TOBE domain; Region: TOBE_2; pfam08402 1117943007165 Cytochrome c2 [Energy production and conversion]; Region: COG3474 1117943007166 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1117943007167 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1117943007168 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1117943007169 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 1117943007170 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 1117943007171 Subunit I/III interface [polypeptide binding]; other site 1117943007172 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 1117943007173 Subunit I/III interface [polypeptide binding]; other site 1117943007174 Predicted small integral membrane protein [Function unknown]; Region: COG5605 1117943007175 Predicted transcriptional regulator [Transcription]; Region: COG1959 1117943007176 Transcriptional regulator; Region: Rrf2; pfam02082 1117943007177 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1117943007178 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1117943007179 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1117943007180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1117943007181 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1117943007182 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1117943007183 Walker A/P-loop; other site 1117943007184 ATP binding site [chemical binding]; other site 1117943007185 Q-loop/lid; other site 1117943007186 ABC transporter signature motif; other site 1117943007187 Walker B; other site 1117943007188 D-loop; other site 1117943007189 H-loop/switch region; other site 1117943007190 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1117943007191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943007192 dimer interface [polypeptide binding]; other site 1117943007193 conserved gate region; other site 1117943007194 putative PBP binding loops; other site 1117943007195 ABC-ATPase subunit interface; other site 1117943007196 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1117943007197 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1117943007198 active site 1117943007199 dimer interface [polypeptide binding]; other site 1117943007200 non-prolyl cis peptide bond; other site 1117943007201 insertion regions; other site 1117943007202 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1117943007203 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943007204 substrate binding pocket [chemical binding]; other site 1117943007205 membrane-bound complex binding site; other site 1117943007206 hinge residues; other site 1117943007207 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943007208 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943007209 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943007210 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943007211 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1117943007212 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1117943007213 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1117943007214 Cupin domain; Region: Cupin_2; pfam07883 1117943007215 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1117943007216 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1117943007217 NAD(P) binding site [chemical binding]; other site 1117943007218 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1117943007219 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1117943007220 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1117943007221 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1117943007222 active site 1117943007223 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 1117943007224 active site 1117943007225 metal binding site [ion binding]; metal-binding site 1117943007226 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1117943007227 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1117943007228 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1117943007229 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 1117943007230 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1117943007231 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1117943007232 metal-binding site [ion binding] 1117943007233 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943007234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943007235 motif II; other site 1117943007236 Predicted integral membrane protein [Function unknown]; Region: COG5473 1117943007237 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1117943007238 Cytochrome c; Region: Cytochrom_C; pfam00034 1117943007239 Cytochrome c; Region: Cytochrom_C; pfam00034 1117943007240 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1117943007241 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1117943007242 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 1117943007243 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 1117943007244 Isochorismatase family; Region: Isochorismatase; pfam00857 1117943007245 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1117943007246 catalytic triad [active] 1117943007247 conserved cis-peptide bond; other site 1117943007248 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943007249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943007250 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943007251 Helix-turn-helix domain; Region: HTH_28; pfam13518 1117943007252 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943007253 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943007254 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943007255 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943007256 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 1117943007257 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1117943007258 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1117943007259 PYR/PP interface [polypeptide binding]; other site 1117943007260 dimer interface [polypeptide binding]; other site 1117943007261 TPP binding site [chemical binding]; other site 1117943007262 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1117943007263 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1117943007264 TPP-binding site [chemical binding]; other site 1117943007265 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1117943007266 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1117943007267 substrate binding site [chemical binding]; other site 1117943007268 ATP binding site [chemical binding]; other site 1117943007269 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1117943007270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 1117943007271 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1117943007272 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1117943007273 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943007274 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943007275 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1117943007276 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943007277 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943007278 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1117943007279 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1117943007280 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1117943007281 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1117943007282 Walker A/P-loop; other site 1117943007283 ATP binding site [chemical binding]; other site 1117943007284 Q-loop/lid; other site 1117943007285 ABC transporter signature motif; other site 1117943007286 Walker B; other site 1117943007287 D-loop; other site 1117943007288 H-loop/switch region; other site 1117943007289 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943007290 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943007291 TM-ABC transporter signature motif; other site 1117943007292 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943007293 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943007294 TM-ABC transporter signature motif; other site 1117943007295 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1117943007296 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1117943007297 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1117943007298 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943007299 DNA binding site [nucleotide binding] 1117943007300 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1117943007301 putative ligand binding site [chemical binding]; other site 1117943007302 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1117943007303 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1117943007304 substrate binding site [chemical binding]; other site 1117943007305 oxyanion hole (OAH) forming residues; other site 1117943007306 trimer interface [polypeptide binding]; other site 1117943007307 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1117943007308 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1117943007309 enoyl-CoA hydratase; Provisional; Region: PRK08140 1117943007310 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1117943007311 substrate binding site [chemical binding]; other site 1117943007312 oxyanion hole (OAH) forming residues; other site 1117943007313 trimer interface [polypeptide binding]; other site 1117943007314 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1117943007315 CoenzymeA binding site [chemical binding]; other site 1117943007316 subunit interaction site [polypeptide binding]; other site 1117943007317 PHB binding site; other site 1117943007318 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 1117943007319 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1117943007320 active site 1117943007321 AMP binding site [chemical binding]; other site 1117943007322 homodimer interface [polypeptide binding]; other site 1117943007323 acyl-activating enzyme (AAE) consensus motif; other site 1117943007324 CoA binding site [chemical binding]; other site 1117943007325 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1117943007326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943007327 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 1117943007328 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 1117943007329 substrate binding site [chemical binding]; other site 1117943007330 dimer interface [polypeptide binding]; other site 1117943007331 NADP binding site [chemical binding]; other site 1117943007332 catalytic residues [active] 1117943007333 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 1117943007334 substrate binding site [chemical binding]; other site 1117943007335 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 1117943007336 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1117943007337 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1117943007338 FAD binding pocket [chemical binding]; other site 1117943007339 FAD binding motif [chemical binding]; other site 1117943007340 phosphate binding motif [ion binding]; other site 1117943007341 beta-alpha-beta structure motif; other site 1117943007342 NAD(p) ribose binding residues [chemical binding]; other site 1117943007343 NAD binding pocket [chemical binding]; other site 1117943007344 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1117943007345 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1117943007346 catalytic loop [active] 1117943007347 iron binding site [ion binding]; other site 1117943007348 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1117943007349 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1117943007350 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1117943007351 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1117943007352 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1117943007353 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1117943007354 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1117943007355 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1117943007356 active site 1117943007357 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1117943007358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943007359 active site 1117943007360 phosphorylation site [posttranslational modification] 1117943007361 intermolecular recognition site; other site 1117943007362 dimerization interface [polypeptide binding]; other site 1117943007363 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943007364 DNA binding residues [nucleotide binding] 1117943007365 dimerization interface [polypeptide binding]; other site 1117943007366 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1117943007367 homodimer interface [polypeptide binding]; other site 1117943007368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943007369 catalytic residue [active] 1117943007370 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1117943007371 malate--CoA ligase subunit beta; Provisional; Region: PRK14046 1117943007372 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1117943007373 CoA-ligase; Region: Ligase_CoA; pfam00549 1117943007374 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1117943007375 CoA binding domain; Region: CoA_binding; smart00881 1117943007376 CoA-ligase; Region: Ligase_CoA; pfam00549 1117943007377 BCCT family transporter; Region: BCCT; pfam02028 1117943007378 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1117943007379 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1117943007380 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1117943007381 NAD binding site [chemical binding]; other site 1117943007382 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1117943007383 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1117943007384 conserved cys residue [active] 1117943007385 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943007386 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943007387 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1117943007388 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1117943007389 conserved cys residue [active] 1117943007390 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943007391 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1117943007392 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1117943007393 NAD binding site [chemical binding]; other site 1117943007394 catalytic Zn binding site [ion binding]; other site 1117943007395 structural Zn binding site [ion binding]; other site 1117943007396 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1117943007397 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1117943007398 FAD binding pocket [chemical binding]; other site 1117943007399 FAD binding motif [chemical binding]; other site 1117943007400 phosphate binding motif [ion binding]; other site 1117943007401 beta-alpha-beta structure motif; other site 1117943007402 NAD binding pocket [chemical binding]; other site 1117943007403 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1117943007404 catalytic loop [active] 1117943007405 iron binding site [ion binding]; other site 1117943007406 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1117943007407 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1117943007408 [2Fe-2S] cluster binding site [ion binding]; other site 1117943007409 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1117943007410 putative alpha subunit interface [polypeptide binding]; other site 1117943007411 putative active site [active] 1117943007412 putative substrate binding site [chemical binding]; other site 1117943007413 Fe binding site [ion binding]; other site 1117943007414 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1117943007415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943007416 active site 1117943007417 phosphorylation site [posttranslational modification] 1117943007418 intermolecular recognition site; other site 1117943007419 dimerization interface [polypeptide binding]; other site 1117943007420 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943007421 DNA binding residues [nucleotide binding] 1117943007422 dimerization interface [polypeptide binding]; other site 1117943007423 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1117943007424 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1117943007425 Response regulator receiver domain; Region: Response_reg; pfam00072 1117943007426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943007427 active site 1117943007428 phosphorylation site [posttranslational modification] 1117943007429 intermolecular recognition site; other site 1117943007430 dimerization interface [polypeptide binding]; other site 1117943007431 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1117943007432 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1117943007433 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943007434 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1117943007435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943007436 putative substrate translocation pore; other site 1117943007437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943007438 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1117943007439 NAD(P) binding site [chemical binding]; other site 1117943007440 active site 1117943007441 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1117943007442 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1117943007443 ATP binding site [chemical binding]; other site 1117943007444 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1117943007445 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1117943007446 substrate binding site [chemical binding]; other site 1117943007447 activation loop (A-loop); other site 1117943007448 activation loop (A-loop); other site 1117943007449 AAA ATPase domain; Region: AAA_16; pfam13191 1117943007450 Predicted ATPase [General function prediction only]; Region: COG3899 1117943007451 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1117943007452 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1117943007453 PAS domain S-box; Region: sensory_box; TIGR00229 1117943007454 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943007455 putative active site [active] 1117943007456 heme pocket [chemical binding]; other site 1117943007457 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1117943007458 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943007459 putative active site [active] 1117943007460 heme pocket [chemical binding]; other site 1117943007461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943007462 putative active site [active] 1117943007463 heme pocket [chemical binding]; other site 1117943007464 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943007465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943007466 dimer interface [polypeptide binding]; other site 1117943007467 phosphorylation site [posttranslational modification] 1117943007468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943007469 ATP binding site [chemical binding]; other site 1117943007470 G-X-G motif; other site 1117943007471 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1117943007472 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 1117943007473 substrate binding site [chemical binding]; other site 1117943007474 Protein of unknown function (DUF521); Region: DUF521; pfam04412 1117943007475 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1117943007476 substrate binding site [chemical binding]; other site 1117943007477 ligand binding site [chemical binding]; other site 1117943007478 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943007479 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943007480 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1117943007481 dimerization interface [polypeptide binding]; other site 1117943007482 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1117943007483 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1117943007484 tetramer interface [polypeptide binding]; other site 1117943007485 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943007486 catalytic residue [active] 1117943007487 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1117943007488 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1117943007489 Walker A/P-loop; other site 1117943007490 ATP binding site [chemical binding]; other site 1117943007491 Q-loop/lid; other site 1117943007492 ABC transporter signature motif; other site 1117943007493 Walker B; other site 1117943007494 D-loop; other site 1117943007495 H-loop/switch region; other site 1117943007496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1117943007497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943007498 putative PBP binding loops; other site 1117943007499 dimer interface [polypeptide binding]; other site 1117943007500 ABC-ATPase subunit interface; other site 1117943007501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943007502 dimer interface [polypeptide binding]; other site 1117943007503 conserved gate region; other site 1117943007504 putative PBP binding loops; other site 1117943007505 ABC-ATPase subunit interface; other site 1117943007506 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1117943007507 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943007508 substrate binding pocket [chemical binding]; other site 1117943007509 membrane-bound complex binding site; other site 1117943007510 hinge residues; other site 1117943007511 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1117943007512 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1117943007513 aspartate aminotransferase; Provisional; Region: PRK05764 1117943007514 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943007515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943007516 homodimer interface [polypeptide binding]; other site 1117943007517 catalytic residue [active] 1117943007518 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1117943007519 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1117943007520 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1117943007521 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1117943007522 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943007523 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1117943007524 dimerization interface [polypeptide binding]; other site 1117943007525 substrate binding pocket [chemical binding]; other site 1117943007526 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1117943007527 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1117943007528 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1117943007529 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1117943007530 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1117943007531 Ligand binding site [chemical binding]; other site 1117943007532 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1117943007533 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1117943007534 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1117943007535 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1117943007536 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1117943007537 active site 2 [active] 1117943007538 active site 1 [active] 1117943007539 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1117943007540 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1117943007541 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1117943007542 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1117943007543 active site 1117943007544 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1117943007545 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1117943007546 NAD(P) binding site [chemical binding]; other site 1117943007547 catalytic residues [active] 1117943007548 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 1117943007549 Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six...; Region: TPP_ComE; cd03372 1117943007550 TPP-binding site; other site 1117943007551 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1117943007552 PYR/PP interface [polypeptide binding]; other site 1117943007553 dimer interface [polypeptide binding]; other site 1117943007554 TPP binding site [chemical binding]; other site 1117943007555 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1117943007556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943007557 putative substrate translocation pore; other site 1117943007558 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943007559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943007560 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1117943007561 putative dimerization interface [polypeptide binding]; other site 1117943007562 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 1117943007563 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1117943007564 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1117943007565 putative active site [active] 1117943007566 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1117943007567 dimer interface [polypeptide binding]; other site 1117943007568 substrate binding site [chemical binding]; other site 1117943007569 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1117943007570 classical (c) SDRs; Region: SDR_c; cd05233 1117943007571 NAD(P) binding site [chemical binding]; other site 1117943007572 active site 1117943007573 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943007574 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1117943007575 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1117943007576 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1117943007577 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943007578 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1117943007579 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1117943007580 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1117943007581 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943007582 Walker A/P-loop; other site 1117943007583 ATP binding site [chemical binding]; other site 1117943007584 Q-loop/lid; other site 1117943007585 ABC transporter signature motif; other site 1117943007586 Walker B; other site 1117943007587 D-loop; other site 1117943007588 H-loop/switch region; other site 1117943007589 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1117943007590 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943007591 Walker A/P-loop; other site 1117943007592 ATP binding site [chemical binding]; other site 1117943007593 Q-loop/lid; other site 1117943007594 ABC transporter signature motif; other site 1117943007595 Walker B; other site 1117943007596 D-loop; other site 1117943007597 H-loop/switch region; other site 1117943007598 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1117943007599 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1117943007600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943007601 dimer interface [polypeptide binding]; other site 1117943007602 conserved gate region; other site 1117943007603 putative PBP binding loops; other site 1117943007604 ABC-ATPase subunit interface; other site 1117943007605 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1117943007606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943007607 dimer interface [polypeptide binding]; other site 1117943007608 conserved gate region; other site 1117943007609 putative PBP binding loops; other site 1117943007610 ABC-ATPase subunit interface; other site 1117943007611 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1117943007612 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1117943007613 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1117943007614 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1117943007615 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1117943007616 Walker A/P-loop; other site 1117943007617 ATP binding site [chemical binding]; other site 1117943007618 Q-loop/lid; other site 1117943007619 ABC transporter signature motif; other site 1117943007620 Walker B; other site 1117943007621 D-loop; other site 1117943007622 H-loop/switch region; other site 1117943007623 TOBE-like domain; Region: TOBE_3; pfam12857 1117943007624 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1117943007625 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943007626 substrate binding pocket [chemical binding]; other site 1117943007627 membrane-bound complex binding site; other site 1117943007628 hinge residues; other site 1117943007629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1117943007630 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1117943007631 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1117943007632 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1117943007633 active site 1117943007634 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1117943007635 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1117943007636 active site 1117943007637 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1117943007638 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1117943007639 active site 1117943007640 non-prolyl cis peptide bond; other site 1117943007641 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1117943007642 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1117943007643 Walker A/P-loop; other site 1117943007644 ATP binding site [chemical binding]; other site 1117943007645 Q-loop/lid; other site 1117943007646 ABC transporter signature motif; other site 1117943007647 Walker B; other site 1117943007648 D-loop; other site 1117943007649 H-loop/switch region; other site 1117943007650 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1117943007651 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1117943007652 Flavin binding site [chemical binding]; other site 1117943007653 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1117943007654 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1117943007655 putative ligand binding site [chemical binding]; other site 1117943007656 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1117943007657 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1117943007658 TM-ABC transporter signature motif; other site 1117943007659 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1117943007660 TM-ABC transporter signature motif; other site 1117943007661 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1117943007662 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1117943007663 Walker A/P-loop; other site 1117943007664 ATP binding site [chemical binding]; other site 1117943007665 Q-loop/lid; other site 1117943007666 ABC transporter signature motif; other site 1117943007667 Walker B; other site 1117943007668 D-loop; other site 1117943007669 H-loop/switch region; other site 1117943007670 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1117943007671 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1117943007672 active site 1117943007673 dimer interface [polypeptide binding]; other site 1117943007674 non-prolyl cis peptide bond; other site 1117943007675 insertion regions; other site 1117943007676 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1117943007677 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 1117943007678 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943007679 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1117943007680 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1117943007681 active site 1117943007682 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1117943007683 catalytic tetrad [active] 1117943007684 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943007685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1117943007686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943007687 dimer interface [polypeptide binding]; other site 1117943007688 conserved gate region; other site 1117943007689 putative PBP binding loops; other site 1117943007690 ABC-ATPase subunit interface; other site 1117943007691 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1117943007692 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1117943007693 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1117943007694 active site 1117943007695 catalytic tetrad [active] 1117943007696 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1117943007697 active site 1117943007698 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1117943007699 catalytic tetrad [active] 1117943007700 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943007701 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943007702 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1117943007703 putative effector binding pocket; other site 1117943007704 putative dimerization interface [polypeptide binding]; other site 1117943007705 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943007706 cyclase homology domain; Region: CHD; cd07302 1117943007707 nucleotidyl binding site; other site 1117943007708 metal binding site [ion binding]; metal-binding site 1117943007709 dimer interface [polypeptide binding]; other site 1117943007710 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1117943007711 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1117943007712 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1117943007713 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 1117943007714 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1117943007715 catalytic site [active] 1117943007716 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1117943007717 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1117943007718 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 1117943007719 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 1117943007720 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1117943007721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1117943007722 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1117943007723 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943007724 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1117943007725 active site 1117943007726 motif I; other site 1117943007727 motif II; other site 1117943007728 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1117943007729 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1117943007730 active site 1117943007731 homotetramer interface [polypeptide binding]; other site 1117943007732 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1117943007733 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943007734 DNA binding residues [nucleotide binding] 1117943007735 dimerization interface [polypeptide binding]; other site 1117943007736 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 1117943007737 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943007738 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943007739 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943007740 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943007741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943007742 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943007743 transposase; Validated; Region: PRK08181 1117943007744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943007745 Walker A motif; other site 1117943007746 ATP binding site [chemical binding]; other site 1117943007747 Integrase core domain; Region: rve; pfam00665 1117943007748 Transposase; Region: HTH_Tnp_1; cl17663 1117943007749 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1117943007750 Peptidase family M23; Region: Peptidase_M23; pfam01551 1117943007751 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1117943007752 Clp amino terminal domain; Region: Clp_N; pfam02861 1117943007753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943007754 Walker A motif; other site 1117943007755 ATP binding site [chemical binding]; other site 1117943007756 Walker B motif; other site 1117943007757 arginine finger; other site 1117943007758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943007759 Walker A motif; other site 1117943007760 ATP binding site [chemical binding]; other site 1117943007761 Walker B motif; other site 1117943007762 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1117943007763 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 1117943007764 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1117943007765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943007766 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1117943007767 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1117943007768 RF-1 domain; Region: RF-1; pfam00472 1117943007769 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 1117943007770 GAF domain; Region: GAF; pfam01590 1117943007771 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1117943007772 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1117943007773 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1117943007774 aspartate kinase; Reviewed; Region: PRK06635 1117943007775 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1117943007776 putative nucleotide binding site [chemical binding]; other site 1117943007777 putative catalytic residues [active] 1117943007778 putative Mg ion binding site [ion binding]; other site 1117943007779 putative aspartate binding site [chemical binding]; other site 1117943007780 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1117943007781 putative allosteric regulatory site; other site 1117943007782 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1117943007783 O-methyltransferase; Region: Methyltransf_2; pfam00891 1117943007784 RibD C-terminal domain; Region: RibD_C; cl17279 1117943007785 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1117943007786 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1117943007787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943007788 S-adenosylmethionine binding site [chemical binding]; other site 1117943007789 SnoaL-like domain; Region: SnoaL_3; pfam13474 1117943007790 SnoaL-like domain; Region: SnoaL_2; pfam12680 1117943007791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319 1117943007792 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1117943007793 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1117943007794 putative active site [active] 1117943007795 catalytic triad [active] 1117943007796 dimer interface [polypeptide binding]; other site 1117943007797 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1117943007798 GSH binding site [chemical binding]; other site 1117943007799 catalytic residues [active] 1117943007800 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1117943007801 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1117943007802 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 1117943007803 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1117943007804 active site 1117943007805 8-oxo-dGMP binding site [chemical binding]; other site 1117943007806 nudix motif; other site 1117943007807 metal binding site [ion binding]; metal-binding site 1117943007808 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943007809 Coenzyme A binding pocket [chemical binding]; other site 1117943007810 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1117943007811 heterotetramer interface [polypeptide binding]; other site 1117943007812 active site pocket [active] 1117943007813 cleavage site 1117943007814 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 1117943007815 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1117943007816 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1117943007817 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1117943007818 SEC-C motif; Region: SEC-C; pfam02810 1117943007819 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1117943007820 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1117943007821 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1117943007822 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 1117943007823 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1117943007824 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1117943007825 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 1117943007826 active site 1117943007827 acyl-activating enzyme (AAE) consensus motif; other site 1117943007828 putative CoA binding site [chemical binding]; other site 1117943007829 AMP binding site [chemical binding]; other site 1117943007830 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 1117943007831 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1117943007832 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1117943007833 active site 1117943007834 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1117943007835 endonuclease III; Region: ENDO3c; smart00478 1117943007836 minor groove reading motif; other site 1117943007837 helix-hairpin-helix signature motif; other site 1117943007838 substrate binding pocket [chemical binding]; other site 1117943007839 active site 1117943007840 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1117943007841 active site 1117943007842 HIGH motif; other site 1117943007843 nucleotide binding site [chemical binding]; other site 1117943007844 active site 1117943007845 KMSKS motif; other site 1117943007846 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1117943007847 short chain dehydrogenase; Provisional; Region: PRK05993 1117943007848 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1117943007849 NADP binding site [chemical binding]; other site 1117943007850 active site 1117943007851 steroid binding site; other site 1117943007852 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 1117943007853 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1117943007854 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1117943007855 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1117943007856 Ligand binding site [chemical binding]; other site 1117943007857 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1117943007858 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1117943007859 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1117943007860 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1117943007861 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 1117943007862 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1117943007863 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1117943007864 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1117943007865 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1117943007866 catalytic residues [active] 1117943007867 argininosuccinate lyase; Provisional; Region: PRK00855 1117943007868 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1117943007869 active sites [active] 1117943007870 tetramer interface [polypeptide binding]; other site 1117943007871 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1117943007872 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1117943007873 active site 1117943007874 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1117943007875 substrate binding site [chemical binding]; other site 1117943007876 catalytic residues [active] 1117943007877 dimer interface [polypeptide binding]; other site 1117943007878 TIGR02302 family protein; Region: aProt_lowcomp 1117943007879 Response regulator receiver domain; Region: Response_reg; pfam00072 1117943007880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943007881 active site 1117943007882 phosphorylation site [posttranslational modification] 1117943007883 intermolecular recognition site; other site 1117943007884 dimerization interface [polypeptide binding]; other site 1117943007885 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1117943007886 active site 1117943007887 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1117943007888 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1117943007889 Walker A/P-loop; other site 1117943007890 ATP binding site [chemical binding]; other site 1117943007891 Q-loop/lid; other site 1117943007892 ABC transporter signature motif; other site 1117943007893 Walker B; other site 1117943007894 D-loop; other site 1117943007895 H-loop/switch region; other site 1117943007896 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1117943007897 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1117943007898 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1117943007899 putative active site [active] 1117943007900 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1117943007901 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1117943007902 putative acyl-acceptor binding pocket; other site 1117943007903 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1117943007904 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1117943007905 putative active site pocket [active] 1117943007906 dimerization interface [polypeptide binding]; other site 1117943007907 putative catalytic residue [active] 1117943007908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 1117943007909 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 1117943007910 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 1117943007911 prephenate dehydrogenase; Validated; Region: PRK08507 1117943007912 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1117943007913 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943007914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943007915 homodimer interface [polypeptide binding]; other site 1117943007916 catalytic residue [active] 1117943007917 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1117943007918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943007919 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1117943007920 aromatic amino acid exporter; Provisional; Region: PRK11689 1117943007921 EamA-like transporter family; Region: EamA; pfam00892 1117943007922 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1117943007923 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1117943007924 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1117943007925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 1117943007926 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1117943007927 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 1117943007928 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 1117943007929 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1117943007930 metal ion-dependent adhesion site (MIDAS); other site 1117943007931 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 1117943007932 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 1117943007933 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1117943007934 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 1117943007935 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1117943007936 HSP70 interaction site [polypeptide binding]; other site 1117943007937 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1117943007938 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1117943007939 Domain of unknown function DUF21; Region: DUF21; pfam01595 1117943007940 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1117943007941 Transporter associated domain; Region: CorC_HlyC; smart01091 1117943007942 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1117943007943 active site 1117943007944 dimer interface [polypeptide binding]; other site 1117943007945 metal binding site [ion binding]; metal-binding site 1117943007946 shikimate kinase; Provisional; Region: PRK13946 1117943007947 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1117943007948 ADP binding site [chemical binding]; other site 1117943007949 magnesium binding site [ion binding]; other site 1117943007950 putative shikimate binding site; other site 1117943007951 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1117943007952 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943007953 active site 1117943007954 DNA binding site [nucleotide binding] 1117943007955 Int/Topo IB signature motif; other site 1117943007956 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1117943007957 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1117943007958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1117943007959 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1117943007960 CPxP motif; other site 1117943007961 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1117943007962 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1117943007963 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1117943007964 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1117943007965 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1117943007966 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1117943007967 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1117943007968 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1117943007969 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1117943007970 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1117943007971 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1117943007972 metal binding site [ion binding]; metal-binding site 1117943007973 putative dimer interface [polypeptide binding]; other site 1117943007974 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943007975 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943007976 putative DNA binding site [nucleotide binding]; other site 1117943007977 putative Zn2+ binding site [ion binding]; other site 1117943007978 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943007979 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1117943007980 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1117943007981 putative NAD(P) binding site [chemical binding]; other site 1117943007982 putative substrate binding site [chemical binding]; other site 1117943007983 catalytic Zn binding site [ion binding]; other site 1117943007984 structural Zn binding site [ion binding]; other site 1117943007985 dimer interface [polypeptide binding]; other site 1117943007986 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1117943007987 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1117943007988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943007989 hypothetical protein; Provisional; Region: PRK06149 1117943007990 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1117943007991 active site 1117943007992 substrate binding site [chemical binding]; other site 1117943007993 ATP binding site [chemical binding]; other site 1117943007994 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1117943007995 inhibitor-cofactor binding pocket; inhibition site 1117943007996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943007997 catalytic residue [active] 1117943007998 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1117943007999 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943008000 DNA-binding site [nucleotide binding]; DNA binding site 1117943008001 UTRA domain; Region: UTRA; pfam07702 1117943008002 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1117943008003 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1117943008004 active site 1117943008005 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1117943008006 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1117943008007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943008008 dimer interface [polypeptide binding]; other site 1117943008009 conserved gate region; other site 1117943008010 putative PBP binding loops; other site 1117943008011 ABC-ATPase subunit interface; other site 1117943008012 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1117943008013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943008014 Walker A/P-loop; other site 1117943008015 ATP binding site [chemical binding]; other site 1117943008016 Q-loop/lid; other site 1117943008017 ABC transporter signature motif; other site 1117943008018 Walker B; other site 1117943008019 D-loop; other site 1117943008020 H-loop/switch region; other site 1117943008021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 1117943008022 Low affinity iron permease; Region: Iron_permease; cl12096 1117943008023 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1117943008024 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1117943008025 active site 1117943008026 catalytic tetrad [active] 1117943008027 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1117943008028 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 1117943008029 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1117943008030 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1117943008031 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1117943008032 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1117943008033 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1117943008034 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1117943008035 Walker A motif; other site 1117943008036 ATP binding site [chemical binding]; other site 1117943008037 Walker B motif; other site 1117943008038 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1117943008039 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1117943008040 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1117943008041 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1117943008042 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1117943008043 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1117943008044 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1117943008045 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1117943008046 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1117943008047 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1117943008048 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1117943008049 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 1117943008050 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 1117943008051 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1117943008052 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1117943008053 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1117943008054 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1117943008055 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943008056 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943008057 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943008058 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1117943008059 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943008060 Walker A/P-loop; other site 1117943008061 ATP binding site [chemical binding]; other site 1117943008062 Q-loop/lid; other site 1117943008063 ABC transporter signature motif; other site 1117943008064 Walker B; other site 1117943008065 D-loop; other site 1117943008066 H-loop/switch region; other site 1117943008067 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943008068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943008069 dimer interface [polypeptide binding]; other site 1117943008070 conserved gate region; other site 1117943008071 putative PBP binding loops; other site 1117943008072 ABC-ATPase subunit interface; other site 1117943008073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943008074 dimer interface [polypeptide binding]; other site 1117943008075 conserved gate region; other site 1117943008076 putative PBP binding loops; other site 1117943008077 ABC-ATPase subunit interface; other site 1117943008078 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943008079 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943008080 MarR family; Region: MarR; pfam01047 1117943008081 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1117943008082 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1117943008083 nucleotide binding site [chemical binding]; other site 1117943008084 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943008085 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943008086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3828 1117943008087 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1117943008088 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1117943008089 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1117943008090 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1117943008091 TM2 domain; Region: TM2; pfam05154 1117943008092 Phage Terminase; Region: Terminase_1; pfam03354 1117943008093 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1117943008094 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1117943008095 catalytic residues [active] 1117943008096 catalytic nucleophile [active] 1117943008097 Recombinase; Region: Recombinase; pfam07508 1117943008098 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1117943008099 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1117943008100 polymerase nucleotide-binding site; other site 1117943008101 DNA-binding residues [nucleotide binding]; DNA binding site 1117943008102 nucleotide binding site [chemical binding]; other site 1117943008103 primase nucleotide-binding site [nucleotide binding]; other site 1117943008104 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 1117943008105 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1117943008106 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1117943008107 Ligand Binding Site [chemical binding]; other site 1117943008108 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 1117943008109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943008110 Coenzyme A binding pocket [chemical binding]; other site 1117943008111 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1117943008112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943008113 active site 1117943008114 phosphorylation site [posttranslational modification] 1117943008115 intermolecular recognition site; other site 1117943008116 dimerization interface [polypeptide binding]; other site 1117943008117 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943008118 DNA binding site [nucleotide binding] 1117943008119 Response regulator receiver domain; Region: Response_reg; pfam00072 1117943008120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943008121 active site 1117943008122 phosphorylation site [posttranslational modification] 1117943008123 intermolecular recognition site; other site 1117943008124 dimerization interface [polypeptide binding]; other site 1117943008125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 1117943008126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5400 1117943008127 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1117943008128 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1117943008129 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1117943008130 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1117943008131 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1117943008132 RNA binding surface [nucleotide binding]; other site 1117943008133 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1117943008134 active site 1117943008135 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1117943008136 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1117943008137 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1117943008138 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1117943008139 DNA binding residues [nucleotide binding] 1117943008140 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1117943008141 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1117943008142 GDP-binding site [chemical binding]; other site 1117943008143 ACT binding site; other site 1117943008144 IMP binding site; other site 1117943008145 potential frameshift: common BLAST hit: gi|227823298|ref|YP_002827270.1| putative permease of the drug/metabolite transporter (DMT) 1117943008146 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1117943008147 EamA-like transporter family; Region: EamA; pfam00892 1117943008148 EamA-like transporter family; Region: EamA; pfam00892 1117943008149 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1117943008150 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1117943008151 ligand binding site [chemical binding]; other site 1117943008152 NAD binding site [chemical binding]; other site 1117943008153 dimerization interface [polypeptide binding]; other site 1117943008154 catalytic site [active] 1117943008155 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1117943008156 putative L-serine binding site [chemical binding]; other site 1117943008157 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 1117943008158 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1117943008159 catalytic residue [active] 1117943008160 LTXXQ motif family protein; Region: LTXXQ; pfam07813 1117943008161 XFP N-terminal domain; Region: XFP_N; pfam09364 1117943008162 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 1117943008163 XFP C-terminal domain; Region: XFP_C; pfam09363 1117943008164 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 1117943008165 FOG: CBS domain [General function prediction only]; Region: COG0517 1117943008166 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 1117943008167 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1117943008168 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943008169 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1117943008170 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1117943008171 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1117943008172 putative dimer interface [polypeptide binding]; other site 1117943008173 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1117943008174 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1117943008175 Walker A/P-loop; other site 1117943008176 ATP binding site [chemical binding]; other site 1117943008177 Q-loop/lid; other site 1117943008178 ABC transporter signature motif; other site 1117943008179 Walker B; other site 1117943008180 D-loop; other site 1117943008181 H-loop/switch region; other site 1117943008182 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1117943008183 FtsX-like permease family; Region: FtsX; pfam02687 1117943008184 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1117943008185 FtsX-like permease family; Region: FtsX; pfam02687 1117943008186 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1117943008187 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943008188 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1117943008189 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1117943008190 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943008191 protein binding site [polypeptide binding]; other site 1117943008192 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1117943008193 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1117943008194 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1117943008195 Beta-Casp domain; Region: Beta-Casp; smart01027 1117943008196 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1117943008197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 1117943008198 Putative glucoamylase; Region: Glycoamylase; pfam10091 1117943008199 ornithine carbamoyltransferase; Validated; Region: PRK02102 1117943008200 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1117943008201 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1117943008202 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1117943008203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943008204 active site 1117943008205 phosphorylation site [posttranslational modification] 1117943008206 intermolecular recognition site; other site 1117943008207 dimerization interface [polypeptide binding]; other site 1117943008208 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943008209 DNA binding site [nucleotide binding] 1117943008210 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1117943008211 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1117943008212 ligand binding site [chemical binding]; other site 1117943008213 flexible hinge region; other site 1117943008214 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1117943008215 putative switch regulator; other site 1117943008216 non-specific DNA interactions [nucleotide binding]; other site 1117943008217 DNA binding site [nucleotide binding] 1117943008218 sequence specific DNA binding site [nucleotide binding]; other site 1117943008219 putative cAMP binding site [chemical binding]; other site 1117943008220 PAS domain S-box; Region: sensory_box; TIGR00229 1117943008221 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943008222 putative active site [active] 1117943008223 heme pocket [chemical binding]; other site 1117943008224 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1117943008225 dimer interface [polypeptide binding]; other site 1117943008226 phosphorylation site [posttranslational modification] 1117943008227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943008228 ATP binding site [chemical binding]; other site 1117943008229 G-X-G motif; other site 1117943008230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943008231 active site 1117943008232 phosphorylation site [posttranslational modification] 1117943008233 intermolecular recognition site; other site 1117943008234 dimerization interface [polypeptide binding]; other site 1117943008235 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1117943008236 CoA binding domain; Region: CoA_binding_2; pfam13380 1117943008237 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1117943008238 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1117943008239 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1117943008240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1117943008241 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1117943008242 Ligand Binding Site [chemical binding]; other site 1117943008243 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1117943008244 Ligand Binding Site [chemical binding]; other site 1117943008245 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1117943008246 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1117943008247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943008248 Walker A motif; other site 1117943008249 ATP binding site [chemical binding]; other site 1117943008250 Walker B motif; other site 1117943008251 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1117943008252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943008253 Integrase core domain; Region: rve; pfam00665 1117943008254 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943008255 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 1117943008256 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1117943008257 BON domain; Region: BON; pfam04972 1117943008258 BON domain; Region: BON; pfam04972 1117943008259 BON domain; Region: BON; pfam04972 1117943008260 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1117943008261 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1117943008262 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943008263 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1117943008264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943008265 motif II; other site 1117943008266 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1117943008267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1117943008268 Predicted kinase [General function prediction only]; Region: COG0645 1117943008269 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1117943008270 active site 1117943008271 Predicted membrane protein [Function unknown]; Region: COG3619 1117943008272 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1117943008273 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943008274 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1117943008275 TAP-like protein; Region: Abhydrolase_4; pfam08386 1117943008276 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1117943008277 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1117943008278 Predicted transporter component [General function prediction only]; Region: COG2391 1117943008279 Sulphur transport; Region: Sulf_transp; pfam04143 1117943008280 Predicted transporter component [General function prediction only]; Region: COG2391 1117943008281 Sulphur transport; Region: Sulf_transp; pfam04143 1117943008282 Arc-like DNA binding domain; Region: Arc; pfam03869 1117943008283 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1117943008284 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1117943008285 active site 1117943008286 catalytic residues [active] 1117943008287 DNA binding site [nucleotide binding] 1117943008288 Int/Topo IB signature motif; other site 1117943008289 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1117943008290 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1117943008291 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 1117943008292 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1117943008293 active site 1117943008294 substrate binding site [chemical binding]; other site 1117943008295 metal binding site [ion binding]; metal-binding site 1117943008296 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1117943008297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943008298 Walker A motif; other site 1117943008299 ATP binding site [chemical binding]; other site 1117943008300 Walker B motif; other site 1117943008301 arginine finger; other site 1117943008302 Peptidase family M41; Region: Peptidase_M41; pfam01434 1117943008303 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1117943008304 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1117943008305 Ligand Binding Site [chemical binding]; other site 1117943008306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 1117943008307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943008308 binding surface 1117943008309 TPR motif; other site 1117943008310 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1117943008311 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1117943008312 ligand binding site [chemical binding]; other site 1117943008313 translocation protein TolB; Provisional; Region: tolB; PRK05137 1117943008314 TolB amino-terminal domain; Region: TolB_N; pfam04052 1117943008315 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1117943008316 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1117943008317 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1117943008318 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1117943008319 TolR protein; Region: tolR; TIGR02801 1117943008320 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1117943008321 TolQ protein; Region: tolQ; TIGR02796 1117943008322 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1117943008323 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1117943008324 putative DNA binding site [nucleotide binding]; other site 1117943008325 putative homodimer interface [polypeptide binding]; other site 1117943008326 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 1117943008327 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1117943008328 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1117943008329 active site 1117943008330 DNA binding site [nucleotide binding] 1117943008331 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1117943008332 DNA binding site [nucleotide binding] 1117943008333 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 1117943008334 nucleotide binding site [chemical binding]; other site 1117943008335 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1117943008336 active site 1117943008337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943008338 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1117943008339 NAD(P) binding site [chemical binding]; other site 1117943008340 active site 1117943008341 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 1117943008342 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1117943008343 substrate binding site; other site 1117943008344 Manganese binding site; other site 1117943008345 dimer interface; other site 1117943008346 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1117943008347 extended (e) SDRs; Region: SDR_e; cd08946 1117943008348 NAD(P) binding site [chemical binding]; other site 1117943008349 active site 1117943008350 substrate binding site [chemical binding]; other site 1117943008351 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1117943008352 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1117943008353 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943008354 phosphodiesterase YaeI; Provisional; Region: PRK11340 1117943008355 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1117943008356 putative active site [active] 1117943008357 putative metal binding site [ion binding]; other site 1117943008358 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1117943008359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943008360 Walker A motif; other site 1117943008361 ATP binding site [chemical binding]; other site 1117943008362 Walker B motif; other site 1117943008363 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1117943008364 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1117943008365 RuvA N terminal domain; Region: RuvA_N; pfam01330 1117943008366 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1117943008367 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1117943008368 active site 1117943008369 putative DNA-binding cleft [nucleotide binding]; other site 1117943008370 dimer interface [polypeptide binding]; other site 1117943008371 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1117943008372 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1117943008373 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1117943008374 hypothetical protein; Validated; Region: PRK00110 1117943008375 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1117943008376 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1117943008377 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1117943008378 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1117943008379 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1117943008380 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943008381 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1117943008382 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1117943008383 putative active site [active] 1117943008384 metal binding site [ion binding]; metal-binding site 1117943008385 homodimer binding site [polypeptide binding]; other site 1117943008386 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1117943008387 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1117943008388 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943008389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943008390 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943008391 dimerization interface [polypeptide binding]; other site 1117943008392 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 1117943008393 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 1117943008394 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1117943008395 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1117943008396 TPP-binding site [chemical binding]; other site 1117943008397 dimer interface [polypeptide binding]; other site 1117943008398 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1117943008399 PYR/PP interface [polypeptide binding]; other site 1117943008400 dimer interface [polypeptide binding]; other site 1117943008401 TPP binding site [chemical binding]; other site 1117943008402 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1117943008403 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1117943008404 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1117943008405 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1117943008406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 1117943008407 Phosphoglycerate kinase; Region: PGK; pfam00162 1117943008408 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1117943008409 substrate binding site [chemical binding]; other site 1117943008410 hinge regions; other site 1117943008411 ADP binding site [chemical binding]; other site 1117943008412 catalytic site [active] 1117943008413 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 1117943008414 active site 1117943008415 intersubunit interface [polypeptide binding]; other site 1117943008416 catalytic residue [active] 1117943008417 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1117943008418 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943008419 cyclase homology domain; Region: CHD; cd07302 1117943008420 nucleotidyl binding site; other site 1117943008421 metal binding site [ion binding]; metal-binding site 1117943008422 dimer interface [polypeptide binding]; other site 1117943008423 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943008424 TPR repeat; Region: TPR_11; pfam13414 1117943008425 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943008426 TPR motif; other site 1117943008427 TPR repeat; Region: TPR_11; pfam13414 1117943008428 binding surface 1117943008429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943008430 binding surface 1117943008431 TPR motif; other site 1117943008432 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1117943008433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943008434 TPR motif; other site 1117943008435 binding surface 1117943008436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943008437 putative substrate translocation pore; other site 1117943008438 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 1117943008439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317 1117943008440 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 1117943008441 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1117943008442 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1117943008443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943008444 Walker A/P-loop; other site 1117943008445 ATP binding site [chemical binding]; other site 1117943008446 Q-loop/lid; other site 1117943008447 ABC transporter signature motif; other site 1117943008448 Walker B; other site 1117943008449 D-loop; other site 1117943008450 H-loop/switch region; other site 1117943008451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1117943008452 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1117943008453 FAD binding domain; Region: FAD_binding_2; pfam00890 1117943008454 hypothetical protein; Validated; Region: PRK09039 1117943008455 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1117943008456 ligand binding site [chemical binding]; other site 1117943008457 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1117943008458 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1117943008459 active site 1117943008460 dimerization interface [polypeptide binding]; other site 1117943008461 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1117943008462 Sel1-like repeats; Region: SEL1; smart00671 1117943008463 Sel1-like repeats; Region: SEL1; smart00671 1117943008464 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1117943008465 thiamine phosphate binding site [chemical binding]; other site 1117943008466 active site 1117943008467 pyrophosphate binding site [ion binding]; other site 1117943008468 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1117943008469 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943008470 dimerization interface [polypeptide binding]; other site 1117943008471 putative DNA binding site [nucleotide binding]; other site 1117943008472 putative Zn2+ binding site [ion binding]; other site 1117943008473 Uncharacterized small protein [Function unknown]; Region: COG5570 1117943008474 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1117943008475 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1117943008476 ATP-grasp domain; Region: ATP-grasp; pfam02222 1117943008477 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1117943008478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943008479 TPR motif; other site 1117943008480 binding surface 1117943008481 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1117943008482 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1117943008483 catalytic site [active] 1117943008484 pyruvate kinase; Provisional; Region: PRK06247 1117943008485 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1117943008486 domain interfaces; other site 1117943008487 active site 1117943008488 Predicted integral membrane protein [Function unknown]; Region: COG5480 1117943008489 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 1117943008490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 1117943008491 hypothetical protein; Provisional; Region: PRK13694 1117943008492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1117943008493 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 1117943008494 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1117943008495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943008496 active site 1117943008497 phosphorylation site [posttranslational modification] 1117943008498 intermolecular recognition site; other site 1117943008499 dimerization interface [polypeptide binding]; other site 1117943008500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943008501 Walker A motif; other site 1117943008502 ATP binding site [chemical binding]; other site 1117943008503 Walker B motif; other site 1117943008504 arginine finger; other site 1117943008505 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1117943008506 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1117943008507 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 1117943008508 active site 1117943008509 Zn binding site [ion binding]; other site 1117943008510 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1117943008511 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1117943008512 PAS fold; Region: PAS_7; pfam12860 1117943008513 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943008514 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943008515 metal binding site [ion binding]; metal-binding site 1117943008516 active site 1117943008517 I-site; other site 1117943008518 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 1117943008519 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 1117943008520 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1117943008521 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1117943008522 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 1117943008523 active site 1117943008524 metal binding site [ion binding]; metal-binding site 1117943008525 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1117943008526 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1117943008527 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1117943008528 ferrochelatase; Reviewed; Region: hemH; PRK00035 1117943008529 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1117943008530 C-terminal domain interface [polypeptide binding]; other site 1117943008531 active site 1117943008532 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1117943008533 active site 1117943008534 N-terminal domain interface [polypeptide binding]; other site 1117943008535 arginine deiminase; Provisional; Region: PRK01388 1117943008536 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1117943008537 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1117943008538 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 1117943008539 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1117943008540 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1117943008541 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943008542 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1117943008543 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1117943008544 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1117943008545 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1117943008546 active site 1117943008547 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1117943008548 PAS fold; Region: PAS_4; pfam08448 1117943008549 PAS fold; Region: PAS_7; pfam12860 1117943008550 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943008551 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943008552 metal binding site [ion binding]; metal-binding site 1117943008553 active site 1117943008554 I-site; other site 1117943008555 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1117943008556 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1117943008557 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1117943008558 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 1117943008559 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1117943008560 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1117943008561 tetramer interface [polypeptide binding]; other site 1117943008562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943008563 catalytic residue [active] 1117943008564 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1117943008565 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1117943008566 active site 1117943008567 tetramer interface; other site 1117943008568 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1117943008569 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1117943008570 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1117943008571 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1117943008572 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 1117943008573 active site 1117943008574 catalytic triad [active] 1117943008575 oxyanion hole [active] 1117943008576 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1117943008577 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1117943008578 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1117943008579 active site 1117943008580 dimer interface [polypeptide binding]; other site 1117943008581 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1117943008582 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1117943008583 active site 1117943008584 FMN binding site [chemical binding]; other site 1117943008585 substrate binding site [chemical binding]; other site 1117943008586 3Fe-4S cluster binding site [ion binding]; other site 1117943008587 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1117943008588 domain interface; other site 1117943008589 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1117943008590 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1117943008591 tetramer interface [polypeptide binding]; other site 1117943008592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943008593 catalytic residue [active] 1117943008594 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1117943008595 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1117943008596 putative dimer interface [polypeptide binding]; other site 1117943008597 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1117943008598 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1117943008599 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1117943008600 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1117943008601 active site 1117943008602 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 1117943008603 Response regulator receiver domain; Region: Response_reg; pfam00072 1117943008604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943008605 active site 1117943008606 phosphorylation site [posttranslational modification] 1117943008607 intermolecular recognition site; other site 1117943008608 dimerization interface [polypeptide binding]; other site 1117943008609 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1117943008610 putative catalytic residues [active] 1117943008611 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1117943008612 Double zinc ribbon; Region: DZR; pfam12773 1117943008613 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1117943008614 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943008615 cyclase homology domain; Region: CHD; cd07302 1117943008616 nucleotidyl binding site; other site 1117943008617 metal binding site [ion binding]; metal-binding site 1117943008618 dimer interface [polypeptide binding]; other site 1117943008619 Predicted ATPase [General function prediction only]; Region: COG3899 1117943008620 AAA ATPase domain; Region: AAA_16; pfam13191 1117943008621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943008622 TPR motif; other site 1117943008623 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1117943008624 binding surface 1117943008625 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1117943008626 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1117943008627 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1117943008628 MarR family; Region: MarR_2; pfam12802 1117943008629 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1117943008630 MarR family; Region: MarR; pfam01047 1117943008631 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 1117943008632 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943008633 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1117943008634 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1117943008635 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943008636 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943008637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943008638 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943008639 dimerization interface [polypeptide binding]; other site 1117943008640 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1117943008641 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1117943008642 active site 1117943008643 catalytic tetrad [active] 1117943008644 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1117943008645 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1117943008646 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1117943008647 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1117943008648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1117943008649 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1117943008650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1117943008651 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1117943008652 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1117943008653 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1117943008654 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1117943008655 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1117943008656 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1117943008657 metal ion-dependent adhesion site (MIDAS); other site 1117943008658 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1117943008659 homodimer interface [polypeptide binding]; other site 1117943008660 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1117943008661 active site pocket [active] 1117943008662 glycogen branching enzyme; Provisional; Region: PRK05402 1117943008663 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1117943008664 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1117943008665 active site 1117943008666 catalytic site [active] 1117943008667 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1117943008668 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1117943008669 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1117943008670 ligand binding site; other site 1117943008671 oligomer interface; other site 1117943008672 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1117943008673 dimer interface [polypeptide binding]; other site 1117943008674 N-terminal domain interface [polypeptide binding]; other site 1117943008675 sulfate 1 binding site; other site 1117943008676 glycogen synthase; Provisional; Region: glgA; PRK00654 1117943008677 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1117943008678 ADP-binding pocket [chemical binding]; other site 1117943008679 homodimer interface [polypeptide binding]; other site 1117943008680 phosphoglucomutase; Region: PLN02307 1117943008681 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 1117943008682 substrate binding site [chemical binding]; other site 1117943008683 dimer interface [polypeptide binding]; other site 1117943008684 active site 1117943008685 metal binding site [ion binding]; metal-binding site 1117943008686 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1117943008687 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1117943008688 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1117943008689 active site 1117943008690 catalytic site [active] 1117943008691 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1117943008692 putative active site [active] 1117943008693 putative catalytic site [active] 1117943008694 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 1117943008695 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 1117943008696 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1117943008697 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1117943008698 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1117943008699 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 1117943008700 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1117943008701 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1117943008702 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1117943008703 TPR repeat; Region: TPR_11; pfam13414 1117943008704 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943008705 binding surface 1117943008706 TPR motif; other site 1117943008707 TPR repeat; Region: TPR_11; pfam13414 1117943008708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943008709 binding surface 1117943008710 TPR motif; other site 1117943008711 TPR repeat; Region: TPR_11; pfam13414 1117943008712 TPR repeat; Region: TPR_11; pfam13414 1117943008713 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943008714 binding surface 1117943008715 TPR motif; other site 1117943008716 Protein of unknown function (DUF992); Region: DUF992; pfam06186 1117943008717 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943008718 cyclase homology domain; Region: CHD; cd07302 1117943008719 nucleotidyl binding site; other site 1117943008720 metal binding site [ion binding]; metal-binding site 1117943008721 dimer interface [polypeptide binding]; other site 1117943008722 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943008723 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943008724 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943008725 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943008726 Helix-turn-helix domain; Region: HTH_28; pfam13518 1117943008727 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943008728 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943008729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943008730 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1117943008731 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1117943008732 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1117943008733 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1117943008734 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1117943008735 ligand binding site [chemical binding]; other site 1117943008736 homodimer interface [polypeptide binding]; other site 1117943008737 NAD(P) binding site [chemical binding]; other site 1117943008738 trimer interface B [polypeptide binding]; other site 1117943008739 trimer interface A [polypeptide binding]; other site 1117943008740 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 1117943008741 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1117943008742 PAS domain; Region: PAS; smart00091 1117943008743 PAS fold; Region: PAS_7; pfam12860 1117943008744 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943008745 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943008746 metal binding site [ion binding]; metal-binding site 1117943008747 active site 1117943008748 I-site; other site 1117943008749 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1117943008750 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1117943008751 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1117943008752 catalytic triad [active] 1117943008753 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1117943008754 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1117943008755 putative ligand binding site [chemical binding]; other site 1117943008756 NAD binding site [chemical binding]; other site 1117943008757 catalytic site [active] 1117943008758 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1117943008759 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943008760 DNA binding site [nucleotide binding] 1117943008761 domain linker motif; other site 1117943008762 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1117943008763 putative dimerization interface [polypeptide binding]; other site 1117943008764 putative ligand binding site [chemical binding]; other site 1117943008765 MarR family; Region: MarR_2; cl17246 1117943008766 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1117943008767 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1117943008768 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1117943008769 P-loop, Walker A motif; other site 1117943008770 Base recognition motif; other site 1117943008771 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1117943008772 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1117943008773 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1117943008774 structural tetrad; other site 1117943008775 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1117943008776 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1117943008777 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1117943008778 trimer interface [polypeptide binding]; other site 1117943008779 active site 1117943008780 substrate binding site [chemical binding]; other site 1117943008781 CoA binding site [chemical binding]; other site 1117943008782 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1117943008783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943008784 Coenzyme A binding pocket [chemical binding]; other site 1117943008785 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1117943008786 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1117943008787 dimer interface [polypeptide binding]; other site 1117943008788 active site 1117943008789 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1117943008790 catalytic residues [active] 1117943008791 substrate binding site [chemical binding]; other site 1117943008792 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943008793 LysR family transcriptional regulator; Provisional; Region: PRK14997 1117943008794 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1117943008795 putative effector binding pocket; other site 1117943008796 dimerization interface [polypeptide binding]; other site 1117943008797 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 1117943008798 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1117943008799 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1117943008800 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1117943008801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1117943008802 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1117943008803 putative metal binding site [ion binding]; other site 1117943008804 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1117943008805 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1117943008806 active site 1117943008807 intersubunit interface [polypeptide binding]; other site 1117943008808 catalytic residue [active] 1117943008809 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 1117943008810 putative active site [active] 1117943008811 putative metal binding residues [ion binding]; other site 1117943008812 signature motif; other site 1117943008813 putative dimer interface [polypeptide binding]; other site 1117943008814 putative phosphate binding site [ion binding]; other site 1117943008815 CHAD domain; Region: CHAD; pfam05235 1117943008816 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 1117943008817 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1117943008818 active site residue [active] 1117943008819 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1117943008820 substrate binding site [chemical binding]; other site 1117943008821 Protein of unknown function (DUF521); Region: DUF521; pfam04412 1117943008822 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 1117943008823 substrate binding site [chemical binding]; other site 1117943008824 ligand binding site [chemical binding]; other site 1117943008825 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1117943008826 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1117943008827 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1117943008828 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943008829 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1117943008830 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1117943008831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943008832 dimer interface [polypeptide binding]; other site 1117943008833 conserved gate region; other site 1117943008834 ABC-ATPase subunit interface; other site 1117943008835 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1117943008836 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1117943008837 Walker A/P-loop; other site 1117943008838 ATP binding site [chemical binding]; other site 1117943008839 Q-loop/lid; other site 1117943008840 ABC transporter signature motif; other site 1117943008841 Walker B; other site 1117943008842 D-loop; other site 1117943008843 H-loop/switch region; other site 1117943008844 NIL domain; Region: NIL; pfam09383 1117943008845 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1117943008846 beta-galactosidase; Region: BGL; TIGR03356 1117943008847 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943008848 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943008849 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1117943008850 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1117943008851 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1117943008852 xylose isomerase; Provisional; Region: PRK05474 1117943008853 xylose isomerase; Region: xylose_isom_A; TIGR02630 1117943008854 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1117943008855 N- and C-terminal domain interface [polypeptide binding]; other site 1117943008856 D-xylulose kinase; Region: XylB; TIGR01312 1117943008857 active site 1117943008858 MgATP binding site [chemical binding]; other site 1117943008859 catalytic site [active] 1117943008860 metal binding site [ion binding]; metal-binding site 1117943008861 xylulose binding site [chemical binding]; other site 1117943008862 homodimer interface [polypeptide binding]; other site 1117943008863 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1117943008864 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943008865 DNA binding site [nucleotide binding] 1117943008866 domain linker motif; other site 1117943008867 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1117943008868 putative ligand binding site [chemical binding]; other site 1117943008869 Cytolysin, a secreted calcineurin-like phosphatase [Cell motility and secretion]; Region: COG5555 1117943008870 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1117943008871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943008872 putative substrate translocation pore; other site 1117943008873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943008874 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1117943008875 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1117943008876 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943008877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1117943008878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943008879 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1117943008880 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943008881 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1117943008882 active site 1117943008883 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943008884 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1117943008885 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943008886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1117943008887 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1117943008888 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1117943008889 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1117943008890 HIGH motif; other site 1117943008891 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1117943008892 active site 1117943008893 KMSKS motif; other site 1117943008894 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1117943008895 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1117943008896 dimer interface [polypeptide binding]; other site 1117943008897 putative anticodon binding site; other site 1117943008898 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1117943008899 motif 1; other site 1117943008900 active site 1117943008901 motif 2; other site 1117943008902 motif 3; other site 1117943008903 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943008904 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1117943008905 active site 1117943008906 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943008907 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 1117943008908 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1117943008909 ATP-dependent DNA ligase; Validated; Region: PRK09247 1117943008910 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 1117943008911 active site 1117943008912 DNA binding site [nucleotide binding] 1117943008913 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1117943008914 DNA binding site [nucleotide binding] 1117943008915 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3452 1117943008916 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943008917 PAS fold; Region: PAS_3; pfam08447 1117943008918 putative active site [active] 1117943008919 heme pocket [chemical binding]; other site 1117943008920 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943008921 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943008922 metal binding site [ion binding]; metal-binding site 1117943008923 active site 1117943008924 I-site; other site 1117943008925 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1117943008926 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 1117943008927 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1117943008928 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1117943008929 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1117943008930 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1117943008931 monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943 1117943008932 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 1117943008933 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 1117943008934 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1117943008935 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 1117943008936 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 1117943008937 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 1117943008938 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1117943008939 active site 1117943008940 SAM binding site [chemical binding]; other site 1117943008941 homodimer interface [polypeptide binding]; other site 1117943008942 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1117943008943 active site 1117943008944 putative homodimer interface [polypeptide binding]; other site 1117943008945 SAM binding site [chemical binding]; other site 1117943008946 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1117943008947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943008948 S-adenosylmethionine binding site [chemical binding]; other site 1117943008949 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1117943008950 active site 1117943008951 SAM binding site [chemical binding]; other site 1117943008952 homodimer interface [polypeptide binding]; other site 1117943008953 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1117943008954 active site 1117943008955 SAM binding site [chemical binding]; other site 1117943008956 homodimer interface [polypeptide binding]; other site 1117943008957 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1117943008958 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1117943008959 precorrin-3B synthase; Region: CobG; TIGR02435 1117943008960 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1117943008961 active site 1117943008962 SAM binding site [chemical binding]; other site 1117943008963 homodimer interface [polypeptide binding]; other site 1117943008964 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1117943008965 ligand binding site [chemical binding]; other site 1117943008966 active site 1117943008967 UGI interface [polypeptide binding]; other site 1117943008968 catalytic site [active] 1117943008969 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1117943008970 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1117943008971 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1117943008972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943008973 dimer interface [polypeptide binding]; other site 1117943008974 conserved gate region; other site 1117943008975 putative PBP binding loops; other site 1117943008976 ABC-ATPase subunit interface; other site 1117943008977 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 1117943008978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943008979 Walker A/P-loop; other site 1117943008980 ATP binding site [chemical binding]; other site 1117943008981 Q-loop/lid; other site 1117943008982 ABC transporter signature motif; other site 1117943008983 Walker B; other site 1117943008984 D-loop; other site 1117943008985 H-loop/switch region; other site 1117943008986 TOBE domain; Region: TOBE; cl01440 1117943008987 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1117943008988 active site 1117943008989 metal binding site [ion binding]; metal-binding site 1117943008990 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943008991 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1117943008992 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1117943008993 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1117943008994 NAD binding site [chemical binding]; other site 1117943008995 homotetramer interface [polypeptide binding]; other site 1117943008996 homodimer interface [polypeptide binding]; other site 1117943008997 active site 1117943008998 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 1117943008999 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1117943009000 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1117943009001 tetramer interface [polypeptide binding]; other site 1117943009002 TPP-binding site [chemical binding]; other site 1117943009003 heterodimer interface [polypeptide binding]; other site 1117943009004 phosphorylation loop region [posttranslational modification] 1117943009005 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1117943009006 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1117943009007 alpha subunit interface [polypeptide binding]; other site 1117943009008 TPP binding site [chemical binding]; other site 1117943009009 heterodimer interface [polypeptide binding]; other site 1117943009010 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1117943009011 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1117943009012 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1117943009013 E3 interaction surface; other site 1117943009014 lipoyl attachment site [posttranslational modification]; other site 1117943009015 e3 binding domain; Region: E3_binding; pfam02817 1117943009016 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1117943009017 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1117943009018 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1117943009019 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1117943009020 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1117943009021 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1117943009022 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1117943009023 dimer interface [polypeptide binding]; other site 1117943009024 active site 1117943009025 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 1117943009026 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1117943009027 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1117943009028 putative active site [active] 1117943009029 putative substrate binding site [chemical binding]; other site 1117943009030 putative cosubstrate binding site; other site 1117943009031 catalytic site [active] 1117943009032 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1117943009033 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1117943009034 C-terminal domain interface [polypeptide binding]; other site 1117943009035 GSH binding site (G-site) [chemical binding]; other site 1117943009036 putative dimer interface [polypeptide binding]; other site 1117943009037 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1117943009038 dimer interface [polypeptide binding]; other site 1117943009039 N-terminal domain interface [polypeptide binding]; other site 1117943009040 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1117943009041 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1117943009042 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1117943009043 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 1117943009044 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1117943009045 MarR family; Region: MarR; pfam01047 1117943009046 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943009047 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1117943009048 putative DNA binding site [nucleotide binding]; other site 1117943009049 putative Zn2+ binding site [ion binding]; other site 1117943009050 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943009051 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1117943009052 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1117943009053 dimer interface [polypeptide binding]; other site 1117943009054 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1117943009055 active site 1117943009056 Fe binding site [ion binding]; other site 1117943009057 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1117943009058 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943009059 DNA binding residues [nucleotide binding] 1117943009060 dimerization interface [polypeptide binding]; other site 1117943009061 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1117943009062 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1117943009063 Walker A/P-loop; other site 1117943009064 ATP binding site [chemical binding]; other site 1117943009065 Q-loop/lid; other site 1117943009066 ABC transporter signature motif; other site 1117943009067 Walker B; other site 1117943009068 D-loop; other site 1117943009069 H-loop/switch region; other site 1117943009070 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1117943009071 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943009072 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943009073 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943009074 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943009075 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943009076 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943009077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943009078 binding surface 1117943009079 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1117943009080 TPR motif; other site 1117943009081 Methyltransferase domain; Region: Methyltransf_25; pfam13649 1117943009082 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 1117943009083 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943009084 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943009085 metal binding site [ion binding]; metal-binding site 1117943009086 active site 1117943009087 I-site; other site 1117943009088 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1117943009089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943009090 NAD(P) binding site [chemical binding]; other site 1117943009091 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1117943009092 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943009093 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1117943009094 classical (c) SDRs; Region: SDR_c; cd05233 1117943009095 NAD(P) binding site [chemical binding]; other site 1117943009096 active site 1117943009097 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1117943009098 classical (c) SDRs; Region: SDR_c; cd05233 1117943009099 NAD(P) binding site [chemical binding]; other site 1117943009100 active site 1117943009101 Proline racemase; Region: Pro_racemase; pfam05544 1117943009102 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1117943009103 betaine aldehyde dehydrogenase; Region: PLN02467 1117943009104 Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110 1117943009105 NAD(P) binding site [chemical binding]; other site 1117943009106 catalytic residues [active] 1117943009107 catalytic residues [active] 1117943009108 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943009109 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1117943009110 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1117943009111 inhibitor site; inhibition site 1117943009112 active site 1117943009113 dimer interface [polypeptide binding]; other site 1117943009114 catalytic residue [active] 1117943009115 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1117943009116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943009117 dimer interface [polypeptide binding]; other site 1117943009118 conserved gate region; other site 1117943009119 putative PBP binding loops; other site 1117943009120 ABC-ATPase subunit interface; other site 1117943009121 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1117943009122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943009123 dimer interface [polypeptide binding]; other site 1117943009124 conserved gate region; other site 1117943009125 putative PBP binding loops; other site 1117943009126 ABC-ATPase subunit interface; other site 1117943009127 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1117943009128 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1117943009129 Walker A/P-loop; other site 1117943009130 ATP binding site [chemical binding]; other site 1117943009131 Q-loop/lid; other site 1117943009132 ABC transporter signature motif; other site 1117943009133 Walker B; other site 1117943009134 D-loop; other site 1117943009135 H-loop/switch region; other site 1117943009136 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943009137 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1117943009138 substrate binding pocket [chemical binding]; other site 1117943009139 membrane-bound complex binding site; other site 1117943009140 hinge residues; other site 1117943009141 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943009142 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943009143 DNA-binding site [nucleotide binding]; DNA binding site 1117943009144 FCD domain; Region: FCD; pfam07729 1117943009145 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1117943009146 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 1117943009147 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1117943009148 dimer interface [polypeptide binding]; other site 1117943009149 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1117943009150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943009151 active site 1117943009152 phosphorylation site [posttranslational modification] 1117943009153 intermolecular recognition site; other site 1117943009154 dimerization interface [polypeptide binding]; other site 1117943009155 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943009156 DNA binding site [nucleotide binding] 1117943009157 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943009158 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943009159 dimerization interface [polypeptide binding]; other site 1117943009160 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943009161 dimer interface [polypeptide binding]; other site 1117943009162 phosphorylation site [posttranslational modification] 1117943009163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943009164 ATP binding site [chemical binding]; other site 1117943009165 Mg2+ binding site [ion binding]; other site 1117943009166 G-X-G motif; other site 1117943009167 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1117943009168 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1117943009169 inhibitor-cofactor binding pocket; inhibition site 1117943009170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943009171 catalytic residue [active] 1117943009172 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1117943009173 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943009174 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943009175 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943009176 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943009177 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943009178 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943009179 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943009180 short chain dehydrogenase; Provisional; Region: PRK06701 1117943009181 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1117943009182 NAD binding site [chemical binding]; other site 1117943009183 metal binding site [ion binding]; metal-binding site 1117943009184 active site 1117943009185 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1117943009186 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 1117943009187 active site 1117943009188 DNA binding site [nucleotide binding] 1117943009189 Int/Topo IB signature motif; other site 1117943009190 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 1117943009191 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1117943009192 active site 1117943009193 metal binding site [ion binding]; metal-binding site 1117943009194 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943009195 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1117943009196 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943009197 active site 1117943009198 DNA binding site [nucleotide binding] 1117943009199 Int/Topo IB signature motif; other site 1117943009200 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1117943009201 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1117943009202 catalytic residues [active] 1117943009203 catalytic nucleophile [active] 1117943009204 Recombinase; Region: Recombinase; pfam07508 1117943009205 Phage Terminase; Region: Terminase_1; pfam03354 1117943009206 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1117943009207 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 1117943009208 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1117943009209 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1117943009210 fructokinase; Reviewed; Region: PRK09557 1117943009211 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1117943009212 nucleotide binding site [chemical binding]; other site 1117943009213 hypothetical protein; Provisional; Region: PRK02487 1117943009214 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1117943009215 dimerization interface [polypeptide binding]; other site 1117943009216 putative active cleft [active] 1117943009217 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1117943009218 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1117943009219 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1117943009220 substrate binding pocket [chemical binding]; other site 1117943009221 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1117943009222 B12 binding site [chemical binding]; other site 1117943009223 cobalt ligand [ion binding]; other site 1117943009224 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1117943009225 choline dehydrogenase; Validated; Region: PRK02106 1117943009226 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1117943009227 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1117943009228 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1117943009229 TM-ABC transporter signature motif; other site 1117943009230 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943009231 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1117943009232 TM-ABC transporter signature motif; other site 1117943009233 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1117943009234 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1117943009235 Walker A/P-loop; other site 1117943009236 ATP binding site [chemical binding]; other site 1117943009237 Q-loop/lid; other site 1117943009238 ABC transporter signature motif; other site 1117943009239 Walker B; other site 1117943009240 D-loop; other site 1117943009241 H-loop/switch region; other site 1117943009242 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1117943009243 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1117943009244 Walker A/P-loop; other site 1117943009245 ATP binding site [chemical binding]; other site 1117943009246 Q-loop/lid; other site 1117943009247 ABC transporter signature motif; other site 1117943009248 Walker B; other site 1117943009249 D-loop; other site 1117943009250 H-loop/switch region; other site 1117943009251 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1117943009252 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1117943009253 putative ligand binding site [chemical binding]; other site 1117943009254 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943009255 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943009256 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943009257 dimerization interface [polypeptide binding]; other site 1117943009258 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1117943009259 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 1117943009260 Predicted periplasmic protein [General function prediction only]; Region: COG3895 1117943009261 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1117943009262 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1117943009263 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1117943009264 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1117943009265 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1117943009266 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1117943009267 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1117943009268 substrate-cofactor binding pocket; other site 1117943009269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943009270 catalytic residue [active] 1117943009271 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1117943009272 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1117943009273 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1117943009274 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1117943009275 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1117943009276 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1117943009277 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1117943009278 Uncharacterized conserved protein [Function unknown]; Region: COG5649 1117943009279 Uncharacterized conserved protein [Function unknown]; Region: COG5649 1117943009280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1117943009281 PAS domain; Region: PAS_9; pfam13426 1117943009282 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1117943009283 Histidine kinase; Region: HisKA_2; pfam07568 1117943009284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943009285 ATP binding site [chemical binding]; other site 1117943009286 Mg2+ binding site [ion binding]; other site 1117943009287 G-X-G motif; other site 1117943009288 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1117943009289 hypothetical protein; Validated; Region: PRK07586 1117943009290 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1117943009291 PYR/PP interface [polypeptide binding]; other site 1117943009292 dimer interface [polypeptide binding]; other site 1117943009293 TPP binding site [chemical binding]; other site 1117943009294 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1117943009295 TPP-binding site [chemical binding]; other site 1117943009296 dimer interface [polypeptide binding]; other site 1117943009297 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1117943009298 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1117943009299 Surface antigen; Region: Bac_surface_Ag; pfam01103 1117943009300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1117943009301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1117943009302 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1117943009303 Family of unknown function (DUF490); Region: DUF490; pfam04357 1117943009304 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1117943009305 putative dimer interface [polypeptide binding]; other site 1117943009306 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943009307 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943009308 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1117943009309 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943009310 Arginase family; Region: Arginase; cd09989 1117943009311 active site 1117943009312 Mn binding site [ion binding]; other site 1117943009313 oligomer interface [polypeptide binding]; other site 1117943009314 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 1117943009315 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1117943009316 inhibitor-cofactor binding pocket; inhibition site 1117943009317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943009318 catalytic residue [active] 1117943009319 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1117943009320 putative CheA interaction surface; other site 1117943009321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943009322 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1117943009323 putative active site [active] 1117943009324 heme pocket [chemical binding]; other site 1117943009325 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943009326 putative active site [active] 1117943009327 heme pocket [chemical binding]; other site 1117943009328 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1117943009329 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1117943009330 dimer interface [polypeptide binding]; other site 1117943009331 putative CheW interface [polypeptide binding]; other site 1117943009332 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943009333 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943009334 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 1117943009335 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1117943009336 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1117943009337 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1117943009338 catalytic loop [active] 1117943009339 iron binding site [ion binding]; other site 1117943009340 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1117943009341 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1117943009342 [4Fe-4S] binding site [ion binding]; other site 1117943009343 molybdopterin cofactor binding site; other site 1117943009344 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1117943009345 molybdopterin cofactor binding site; other site 1117943009346 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 1117943009347 putative dimer interface [polypeptide binding]; other site 1117943009348 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1117943009349 SLBB domain; Region: SLBB; pfam10531 1117943009350 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1117943009351 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 1117943009352 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 1117943009353 putative dimer interface [polypeptide binding]; other site 1117943009354 [2Fe-2S] cluster binding site [ion binding]; other site 1117943009355 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943009356 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943009357 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1117943009358 dimerization interface [polypeptide binding]; other site 1117943009359 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1117943009360 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1117943009361 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1117943009362 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1117943009363 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1117943009364 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1117943009365 Walker A/P-loop; other site 1117943009366 ATP binding site [chemical binding]; other site 1117943009367 Q-loop/lid; other site 1117943009368 ABC transporter signature motif; other site 1117943009369 Walker B; other site 1117943009370 D-loop; other site 1117943009371 H-loop/switch region; other site 1117943009372 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1117943009373 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1117943009374 Walker A/P-loop; other site 1117943009375 ATP binding site [chemical binding]; other site 1117943009376 Q-loop/lid; other site 1117943009377 ABC transporter signature motif; other site 1117943009378 Walker B; other site 1117943009379 D-loop; other site 1117943009380 H-loop/switch region; other site 1117943009381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943009382 dimer interface [polypeptide binding]; other site 1117943009383 conserved gate region; other site 1117943009384 putative PBP binding loops; other site 1117943009385 ABC-ATPase subunit interface; other site 1117943009386 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943009387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943009388 dimer interface [polypeptide binding]; other site 1117943009389 conserved gate region; other site 1117943009390 putative PBP binding loops; other site 1117943009391 ABC-ATPase subunit interface; other site 1117943009392 Predicted small integral membrane protein [Function unknown]; Region: COG5477 1117943009393 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943009394 xanthine permease; Region: pbuX; TIGR03173 1117943009395 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1117943009396 nucleoside/Zn binding site; other site 1117943009397 dimer interface [polypeptide binding]; other site 1117943009398 catalytic motif [active] 1117943009399 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1117943009400 metal binding site 2 [ion binding]; metal-binding site 1117943009401 putative DNA binding helix; other site 1117943009402 metal binding site 1 [ion binding]; metal-binding site 1117943009403 dimer interface [polypeptide binding]; other site 1117943009404 structural Zn2+ binding site [ion binding]; other site 1117943009405 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1117943009406 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1117943009407 metal binding site [ion binding]; metal-binding site 1117943009408 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1117943009409 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1117943009410 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1117943009411 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1117943009412 ABC-ATPase subunit interface; other site 1117943009413 dimer interface [polypeptide binding]; other site 1117943009414 putative PBP binding regions; other site 1117943009415 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1117943009416 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1117943009417 ABC-ATPase subunit interface; other site 1117943009418 dimer interface [polypeptide binding]; other site 1117943009419 putative PBP binding regions; other site 1117943009420 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943009421 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943009422 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1117943009423 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943009424 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1117943009425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943009426 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 1117943009427 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1117943009428 gamma subunit interface [polypeptide binding]; other site 1117943009429 epsilon subunit interface [polypeptide binding]; other site 1117943009430 LBP interface [polypeptide binding]; other site 1117943009431 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1117943009432 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1117943009433 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1117943009434 alpha subunit interaction interface [polypeptide binding]; other site 1117943009435 Walker A motif; other site 1117943009436 ATP binding site [chemical binding]; other site 1117943009437 Walker B motif; other site 1117943009438 inhibitor binding site; inhibition site 1117943009439 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1117943009440 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1117943009441 core domain interface [polypeptide binding]; other site 1117943009442 delta subunit interface [polypeptide binding]; other site 1117943009443 epsilon subunit interface [polypeptide binding]; other site 1117943009444 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1117943009445 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1117943009446 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1117943009447 beta subunit interaction interface [polypeptide binding]; other site 1117943009448 Walker A motif; other site 1117943009449 ATP binding site [chemical binding]; other site 1117943009450 Walker B motif; other site 1117943009451 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1117943009452 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1117943009453 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1117943009454 primosome assembly protein PriA; Validated; Region: PRK05580 1117943009455 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1117943009456 ATP binding site [chemical binding]; other site 1117943009457 putative Mg++ binding site [ion binding]; other site 1117943009458 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1117943009459 nucleotide binding region [chemical binding]; other site 1117943009460 ATP-binding site [chemical binding]; other site 1117943009461 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1117943009462 active site 1117943009463 intersubunit interactions; other site 1117943009464 catalytic residue [active] 1117943009465 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1117943009466 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1117943009467 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943009468 Putative hemolysin [General function prediction only]; Region: COG3176 1117943009469 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1117943009470 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1117943009471 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943009472 active site 1117943009473 DNA binding site [nucleotide binding] 1117943009474 Int/Topo IB signature motif; other site 1117943009475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 1117943009476 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1117943009477 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 1117943009478 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1117943009479 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1117943009480 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1117943009481 short chain dehydrogenase; Provisional; Region: PRK06123 1117943009482 classical (c) SDRs; Region: SDR_c; cd05233 1117943009483 NAD(P) binding site [chemical binding]; other site 1117943009484 active site 1117943009485 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1117943009486 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1117943009487 E3 interaction surface; other site 1117943009488 lipoyl attachment site [posttranslational modification]; other site 1117943009489 e3 binding domain; Region: E3_binding; pfam02817 1117943009490 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1117943009491 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1117943009492 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1117943009493 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1117943009494 TPP-binding site [chemical binding]; other site 1117943009495 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1117943009496 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1117943009497 CoA binding domain; Region: CoA_binding; smart00881 1117943009498 CoA-ligase; Region: Ligase_CoA; pfam00549 1117943009499 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1117943009500 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1117943009501 CoA-ligase; Region: Ligase_CoA; pfam00549 1117943009502 malate dehydrogenase; Reviewed; Region: PRK06223 1117943009503 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1117943009504 NAD(P) binding site [chemical binding]; other site 1117943009505 dimer interface [polypeptide binding]; other site 1117943009506 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1117943009507 substrate binding site [chemical binding]; other site 1117943009508 Predicted ATPase [General function prediction only]; Region: COG1485 1117943009509 Protease inhibitor Inh; Region: Inh; pfam02974 1117943009510 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 1117943009511 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1117943009512 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1117943009513 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 1117943009514 L-aspartate oxidase; Provisional; Region: PRK06175 1117943009515 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1117943009516 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 1117943009517 putative SdhC subunit interface [polypeptide binding]; other site 1117943009518 putative proximal heme binding site [chemical binding]; other site 1117943009519 putative Iron-sulfur protein interface [polypeptide binding]; other site 1117943009520 putative proximal quinone binding site; other site 1117943009521 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1117943009522 Iron-sulfur protein interface; other site 1117943009523 proximal quinone binding site [chemical binding]; other site 1117943009524 SdhD (CybS) interface [polypeptide binding]; other site 1117943009525 proximal heme binding site [chemical binding]; other site 1117943009526 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1117943009527 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1117943009528 substrate binding site [chemical binding]; other site 1117943009529 ligand binding site [chemical binding]; other site 1117943009530 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1117943009531 catalytic core [active] 1117943009532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1117943009533 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1117943009534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943009535 active site 1117943009536 phosphorylation site [posttranslational modification] 1117943009537 intermolecular recognition site; other site 1117943009538 dimerization interface [polypeptide binding]; other site 1117943009539 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943009540 DNA binding site [nucleotide binding] 1117943009541 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1117943009542 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1117943009543 ligand binding site [chemical binding]; other site 1117943009544 flexible hinge region; other site 1117943009545 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1117943009546 putative catalytic site [active] 1117943009547 putative phosphate binding site [ion binding]; other site 1117943009548 active site 1117943009549 metal binding site A [ion binding]; metal-binding site 1117943009550 DNA binding site [nucleotide binding] 1117943009551 putative AP binding site [nucleotide binding]; other site 1117943009552 putative metal binding site B [ion binding]; other site 1117943009553 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1117943009554 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1117943009555 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1117943009556 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1117943009557 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1117943009558 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1117943009559 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1117943009560 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1117943009561 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1117943009562 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1117943009563 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1117943009564 active site 1117943009565 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1117943009566 catalytic triad [active] 1117943009567 dimer interface [polypeptide binding]; other site 1117943009568 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 1117943009569 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1117943009570 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 1117943009571 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1117943009572 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1117943009573 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1117943009574 substrate binding site [chemical binding]; other site 1117943009575 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1117943009576 homotrimer interaction site [polypeptide binding]; other site 1117943009577 putative active site [active] 1117943009578 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1117943009579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943009580 Walker A motif; other site 1117943009581 ATP binding site [chemical binding]; other site 1117943009582 Walker B motif; other site 1117943009583 arginine finger; other site 1117943009584 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 1117943009585 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1117943009586 proposed active site lysine [active] 1117943009587 conserved cys residue [active] 1117943009588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 1117943009589 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1117943009590 active site 1117943009591 catalytic residues [active] 1117943009592 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1117943009593 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 1117943009594 putative active site [active] 1117943009595 catalytic site [active] 1117943009596 nuclease NucT; Provisional; Region: PRK13912 1117943009597 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128 1117943009598 putative active site [active] 1117943009599 putative catalytic site [active] 1117943009600 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1117943009601 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1117943009602 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1117943009603 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1117943009604 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1117943009605 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1117943009606 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1117943009607 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1117943009608 GTP1/OBG; Region: GTP1_OBG; pfam01018 1117943009609 Obg GTPase; Region: Obg; cd01898 1117943009610 G1 box; other site 1117943009611 GTP/Mg2+ binding site [chemical binding]; other site 1117943009612 Switch I region; other site 1117943009613 G2 box; other site 1117943009614 G3 box; other site 1117943009615 Switch II region; other site 1117943009616 G4 box; other site 1117943009617 G5 box; other site 1117943009618 gamma-glutamyl kinase; Provisional; Region: PRK05429 1117943009619 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1117943009620 nucleotide binding site [chemical binding]; other site 1117943009621 homotetrameric interface [polypeptide binding]; other site 1117943009622 putative phosphate binding site [ion binding]; other site 1117943009623 putative allosteric binding site; other site 1117943009624 PUA domain; Region: PUA; pfam01472 1117943009625 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1117943009626 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1117943009627 putative catalytic cysteine [active] 1117943009628 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1117943009629 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1117943009630 active site 1117943009631 (T/H)XGH motif; other site 1117943009632 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1117943009633 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1117943009634 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1117943009635 Peptidase family M23; Region: Peptidase_M23; pfam01551 1117943009636 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1117943009637 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1117943009638 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1117943009639 protein binding site [polypeptide binding]; other site 1117943009640 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1117943009641 Catalytic dyad [active] 1117943009642 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1117943009643 NodB motif; other site 1117943009644 putative active site [active] 1117943009645 putative catalytic site [active] 1117943009646 Zn binding site [ion binding]; other site 1117943009647 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1117943009648 putative active site [active] 1117943009649 Ap4A binding site [chemical binding]; other site 1117943009650 nudix motif; other site 1117943009651 putative metal binding site [ion binding]; other site 1117943009652 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1117943009653 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1117943009654 heme binding site [chemical binding]; other site 1117943009655 ferroxidase pore; other site 1117943009656 ferroxidase diiron center [ion binding]; other site 1117943009657 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1117943009658 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1117943009659 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1117943009660 putative active site [active] 1117943009661 putative PHP Thumb interface [polypeptide binding]; other site 1117943009662 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1117943009663 generic binding surface II; other site 1117943009664 generic binding surface I; other site 1117943009665 DNA Polymerase Y-family; Region: PolY_like; cd03468 1117943009666 active site 1117943009667 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1117943009668 DNA binding site [nucleotide binding] 1117943009669 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1117943009670 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1117943009671 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1117943009672 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1117943009673 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1117943009674 catalytic residues [active] 1117943009675 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943009676 TPR motif; other site 1117943009677 binding surface 1117943009678 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 1117943009679 putative deacylase active site [active] 1117943009680 amidase; Provisional; Region: PRK07056 1117943009681 amidase; Validated; Region: PRK05962 1117943009682 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1117943009683 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1117943009684 putative active site [active] 1117943009685 putative metal binding site [ion binding]; other site 1117943009686 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1117943009687 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1117943009688 G1 box; other site 1117943009689 putative GEF interaction site [polypeptide binding]; other site 1117943009690 GTP/Mg2+ binding site [chemical binding]; other site 1117943009691 Switch I region; other site 1117943009692 G2 box; other site 1117943009693 G3 box; other site 1117943009694 Switch II region; other site 1117943009695 G4 box; other site 1117943009696 G5 box; other site 1117943009697 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1117943009698 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1117943009699 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1117943009700 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943009701 Coenzyme A binding pocket [chemical binding]; other site 1117943009702 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1117943009703 dimer interface [polypeptide binding]; other site 1117943009704 substrate binding site [chemical binding]; other site 1117943009705 metal binding sites [ion binding]; metal-binding site 1117943009706 hypothetical protein; Validated; Region: PRK01310 1117943009707 YGGT family; Region: YGGT; pfam02325 1117943009708 H+ Antiporter protein; Region: 2A0121; TIGR00900 1117943009709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943009710 putative substrate translocation pore; other site 1117943009711 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1117943009712 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1117943009713 catalytic triad [active] 1117943009714 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 1117943009715 putative metal binding site [ion binding]; other site 1117943009716 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 1117943009717 HemY protein N-terminus; Region: HemY_N; pfam07219 1117943009718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 1117943009719 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1117943009720 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1117943009721 active site 1117943009722 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1117943009723 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1117943009724 domain interfaces; other site 1117943009725 active site 1117943009726 UGMP family protein; Validated; Region: PRK09604 1117943009727 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1117943009728 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1117943009729 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1117943009730 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1117943009731 YciI-like protein; Reviewed; Region: PRK12865 1117943009732 Uncharacterized conserved protein [Function unknown]; Region: COG2947 1117943009733 Predicted methyltransferase [General function prediction only]; Region: COG3897 1117943009734 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1117943009735 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1117943009736 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943009737 substrate binding pocket [chemical binding]; other site 1117943009738 membrane-bound complex binding site; other site 1117943009739 hinge residues; other site 1117943009740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943009741 dimer interface [polypeptide binding]; other site 1117943009742 conserved gate region; other site 1117943009743 putative PBP binding loops; other site 1117943009744 ABC-ATPase subunit interface; other site 1117943009745 hypothetical protein; Provisional; Region: PRK10621 1117943009746 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1117943009747 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1117943009748 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1117943009749 RimM N-terminal domain; Region: RimM; pfam01782 1117943009750 PRC-barrel domain; Region: PRC; pfam05239 1117943009751 chorismate mutase; Provisional; Region: PRK09239 1117943009752 signal recognition particle protein; Provisional; Region: PRK10867 1117943009753 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1117943009754 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1117943009755 P loop; other site 1117943009756 GTP binding site [chemical binding]; other site 1117943009757 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1117943009758 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1117943009759 MarR family; Region: MarR_2; pfam12802 1117943009760 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1117943009761 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1117943009762 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 1117943009763 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1117943009764 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1117943009765 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1117943009766 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1117943009767 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1117943009768 FeS/SAM binding site; other site 1117943009769 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1117943009770 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1117943009771 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1117943009772 intracellular septation protein A; Reviewed; Region: PRK00259 1117943009773 hypothetical protein; Provisional; Region: PRK00944 1117943009774 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 1117943009775 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1117943009776 catalytic residues [active] 1117943009777 central insert; other site 1117943009778 heme exporter protein CcmC; Region: ccmC; TIGR01191 1117943009779 heme exporter protein CcmB; Region: ccmB; TIGR01190 1117943009780 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 1117943009781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943009782 Walker A/P-loop; other site 1117943009783 ATP binding site [chemical binding]; other site 1117943009784 Q-loop/lid; other site 1117943009785 ABC transporter signature motif; other site 1117943009786 Walker B; other site 1117943009787 D-loop; other site 1117943009788 H-loop/switch region; other site 1117943009789 aconitate hydratase; Validated; Region: PRK09277 1117943009790 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1117943009791 substrate binding site [chemical binding]; other site 1117943009792 ligand binding site [chemical binding]; other site 1117943009793 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1117943009794 substrate binding site [chemical binding]; other site 1117943009795 Uncharacterized secreted protein [Function unknown]; Region: COG5429 1117943009796 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 1117943009797 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1117943009798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943009799 Coenzyme A binding pocket [chemical binding]; other site 1117943009800 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1117943009801 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1117943009802 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1117943009803 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1117943009804 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1117943009805 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1117943009806 Walker A/P-loop; other site 1117943009807 ATP binding site [chemical binding]; other site 1117943009808 Q-loop/lid; other site 1117943009809 ABC transporter signature motif; other site 1117943009810 Walker B; other site 1117943009811 D-loop; other site 1117943009812 H-loop/switch region; other site 1117943009813 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1117943009814 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1117943009815 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1117943009816 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1117943009817 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1117943009818 active site 1117943009819 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 1117943009820 aromatic arch; other site 1117943009821 DCoH dimer interaction site [polypeptide binding]; other site 1117943009822 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1117943009823 DCoH tetramer interaction site [polypeptide binding]; other site 1117943009824 substrate binding site [chemical binding]; other site 1117943009825 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1117943009826 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1117943009827 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1117943009828 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1117943009829 FeS/SAM binding site; other site 1117943009830 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1117943009831 argininosuccinate synthase; Provisional; Region: PRK13820 1117943009832 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1117943009833 ANP binding site [chemical binding]; other site 1117943009834 Substrate Binding Site II [chemical binding]; other site 1117943009835 Substrate Binding Site I [chemical binding]; other site 1117943009836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943009837 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1117943009838 putative substrate translocation pore; other site 1117943009839 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1117943009840 MarR family; Region: MarR_2; pfam12802 1117943009841 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1117943009842 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1117943009843 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1117943009844 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1117943009845 Thiamine pyrophosphokinase; Region: TPK; cd07995 1117943009846 active site 1117943009847 dimerization interface [polypeptide binding]; other site 1117943009848 thiamine binding site [chemical binding]; other site 1117943009849 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1117943009850 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1117943009851 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1117943009852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943009853 putative PBP binding loops; other site 1117943009854 dimer interface [polypeptide binding]; other site 1117943009855 ABC-ATPase subunit interface; other site 1117943009856 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 1117943009857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943009858 Walker A/P-loop; other site 1117943009859 ATP binding site [chemical binding]; other site 1117943009860 Q-loop/lid; other site 1117943009861 ABC transporter signature motif; other site 1117943009862 Walker B; other site 1117943009863 D-loop; other site 1117943009864 H-loop/switch region; other site 1117943009865 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 1117943009866 Peptidase family M48; Region: Peptidase_M48; pfam01435 1117943009867 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1117943009868 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1117943009869 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 1117943009870 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1117943009871 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1117943009872 DNA binding residues [nucleotide binding] 1117943009873 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1117943009874 Ferredoxin [Energy production and conversion]; Region: COG1146 1117943009875 4Fe-4S binding domain; Region: Fer4; pfam00037 1117943009876 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1117943009877 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1117943009878 RNA binding surface [nucleotide binding]; other site 1117943009879 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1117943009880 ATP binding site [chemical binding]; other site 1117943009881 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1117943009882 putative Mg++ binding site [ion binding]; other site 1117943009883 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1117943009884 nucleotide binding region [chemical binding]; other site 1117943009885 ATP-binding site [chemical binding]; other site 1117943009886 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1117943009887 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 1117943009888 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1117943009889 NAD(P) binding site [chemical binding]; other site 1117943009890 homotetramer interface [polypeptide binding]; other site 1117943009891 homodimer interface [polypeptide binding]; other site 1117943009892 active site 1117943009893 putative acyltransferase; Provisional; Region: PRK05790 1117943009894 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1117943009895 dimer interface [polypeptide binding]; other site 1117943009896 active site 1117943009897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 1117943009898 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 1117943009899 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 1117943009900 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1117943009901 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1117943009902 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943009903 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 1117943009904 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1117943009905 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1117943009906 putative C-terminal domain interface [polypeptide binding]; other site 1117943009907 putative GSH binding site (G-site) [chemical binding]; other site 1117943009908 putative dimer interface [polypeptide binding]; other site 1117943009909 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1117943009910 putative N-terminal domain interface [polypeptide binding]; other site 1117943009911 putative dimer interface [polypeptide binding]; other site 1117943009912 putative substrate binding pocket (H-site) [chemical binding]; other site 1117943009913 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1117943009914 Transglycosylase; Region: Transgly; cl17702 1117943009915 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1117943009916 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1117943009917 substrate binding pocket [chemical binding]; other site 1117943009918 chain length determination region; other site 1117943009919 substrate-Mg2+ binding site; other site 1117943009920 catalytic residues [active] 1117943009921 aspartate-rich region 1; other site 1117943009922 active site lid residues [active] 1117943009923 aspartate-rich region 2; other site 1117943009924 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1117943009925 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943009926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943009927 homodimer interface [polypeptide binding]; other site 1117943009928 catalytic residue [active] 1117943009929 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1117943009930 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1117943009931 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1117943009932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943009933 putative substrate translocation pore; other site 1117943009934 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1117943009935 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1117943009936 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943009937 active site 1117943009938 metal binding site [ion binding]; metal-binding site 1117943009939 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1117943009940 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1117943009941 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1117943009942 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1117943009943 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943009944 substrate binding pocket [chemical binding]; other site 1117943009945 membrane-bound complex binding site; other site 1117943009946 hinge residues; other site 1117943009947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943009948 dimer interface [polypeptide binding]; other site 1117943009949 conserved gate region; other site 1117943009950 putative PBP binding loops; other site 1117943009951 ABC-ATPase subunit interface; other site 1117943009952 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1117943009953 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1117943009954 Walker A/P-loop; other site 1117943009955 ATP binding site [chemical binding]; other site 1117943009956 Q-loop/lid; other site 1117943009957 ABC transporter signature motif; other site 1117943009958 Walker B; other site 1117943009959 D-loop; other site 1117943009960 H-loop/switch region; other site 1117943009961 pyruvate carboxylase; Reviewed; Region: PRK12999 1117943009962 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1117943009963 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1117943009964 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1117943009965 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1117943009966 active site 1117943009967 catalytic residues [active] 1117943009968 metal binding site [ion binding]; metal-binding site 1117943009969 homodimer binding site [polypeptide binding]; other site 1117943009970 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1117943009971 carboxyltransferase (CT) interaction site; other site 1117943009972 biotinylation site [posttranslational modification]; other site 1117943009973 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1117943009974 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943009975 DNA binding residues [nucleotide binding] 1117943009976 dimerization interface [polypeptide binding]; other site 1117943009977 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943009978 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1117943009979 Integrase core domain; Region: rve; pfam00665 1117943009980 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1117943009981 potential frameshift: common BLAST hit: gi|16263572|ref|NP_436365.1| TRm24 transposase 1117943009982 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1117943009983 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1117943009984 DNA-binding interface [nucleotide binding]; DNA binding site 1117943009985 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1117943009986 Integrase core domain; Region: rve; pfam00665 1117943009987 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1117943009988 DNA-binding site [nucleotide binding]; DNA binding site 1117943009989 RNA-binding motif; other site 1117943009990 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1117943009991 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943009992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943009993 homodimer interface [polypeptide binding]; other site 1117943009994 catalytic residue [active] 1117943009995 choline dehydrogenase; Validated; Region: PRK02106 1117943009996 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1117943009997 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1117943009998 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1117943009999 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1117943010000 active site 1117943010001 FMN binding site [chemical binding]; other site 1117943010002 substrate binding site [chemical binding]; other site 1117943010003 putative catalytic residue [active] 1117943010004 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 1117943010005 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1117943010006 short chain dehydrogenase; Validated; Region: PRK06182 1117943010007 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1117943010008 NADP binding site [chemical binding]; other site 1117943010009 active site 1117943010010 steroid binding site; other site 1117943010011 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 1117943010012 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1117943010013 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1117943010014 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1117943010015 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943010016 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943010017 Winged helix-turn helix; Region: HTH_33; pfam13592 1117943010018 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943010019 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943010020 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1117943010021 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1117943010022 catalytic residues [active] 1117943010023 catalytic nucleophile [active] 1117943010024 Presynaptic Site I dimer interface [polypeptide binding]; other site 1117943010025 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1117943010026 Synaptic Flat tetramer interface [polypeptide binding]; other site 1117943010027 Synaptic Site I dimer interface [polypeptide binding]; other site 1117943010028 DNA binding site [nucleotide binding] 1117943010029 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1117943010030 DNA-binding interface [nucleotide binding]; DNA binding site 1117943010031 Integrase core domain; Region: rve; pfam00665 1117943010032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1117943010033 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 1117943010034 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943010035 potential frameshift: common BLAST hit: gi|190410096|ref|YP_001965620.1| putative transposase protein 1117943010036 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1117943010037 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1117943010038 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1117943010039 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1117943010040 putative active site [active] 1117943010041 putative PHP Thumb interface [polypeptide binding]; other site 1117943010042 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1117943010043 generic binding surface I; other site 1117943010044 generic binding surface II; other site 1117943010045 DNA Polymerase Y-family; Region: PolY_like; cd03468 1117943010046 active site 1117943010047 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1117943010048 DNA binding site [nucleotide binding] 1117943010049 Uncharacterized conserved protein [Function unknown]; Region: COG4544 1117943010050 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1117943010051 active site 1117943010052 DNA polymerase IV; Validated; Region: PRK02406 1117943010053 DNA binding site [nucleotide binding] 1117943010054 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1117943010055 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1117943010056 Meiotically up-regulated gene 113; Region: MUG113; pfam13455 1117943010057 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1117943010058 active site 1117943010059 iron coordination sites [ion binding]; other site 1117943010060 substrate binding pocket [chemical binding]; other site 1117943010061 AAA ATPase domain; Region: AAA_16; pfam13191 1117943010062 AAA domain; Region: AAA_21; pfam13304 1117943010063 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943010064 Walker B; other site 1117943010065 D-loop; other site 1117943010066 H-loop/switch region; other site 1117943010067 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1117943010068 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943010069 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943010070 non-specific DNA binding site [nucleotide binding]; other site 1117943010071 salt bridge; other site 1117943010072 sequence-specific DNA binding site [nucleotide binding]; other site 1117943010073 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1117943010074 potential frameshift: common BLAST hit: gi|190410096|ref|YP_001965620.1| putative transposase protein 1117943010075 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1117943010076 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1117943010077 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1117943010078 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1117943010079 catalytic residues [active] 1117943010080 catalytic nucleophile [active] 1117943010081 Presynaptic Site I dimer interface [polypeptide binding]; other site 1117943010082 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1117943010083 Synaptic Flat tetramer interface [polypeptide binding]; other site 1117943010084 Synaptic Site I dimer interface [polypeptide binding]; other site 1117943010085 DNA binding site [nucleotide binding] 1117943010086 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1117943010087 DNA-binding interface [nucleotide binding]; DNA binding site 1117943010088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943010089 Integrase core domain; Region: rve; pfam00665 1117943010090 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1117943010091 active site 1117943010092 nucleophile elbow; other site 1117943010093 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1117943010094 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 1117943010095 Zn binding site [ion binding]; other site 1117943010096 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 1117943010097 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943010098 Integrase core domain; Region: rve; pfam00665 1117943010099 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1117943010100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943010101 Walker A motif; other site 1117943010102 ATP binding site [chemical binding]; other site 1117943010103 Walker B motif; other site 1117943010104 arginine finger; other site 1117943010105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943010106 putative DNA binding site [nucleotide binding]; other site 1117943010107 putative Zn2+ binding site [ion binding]; other site 1117943010108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943010109 Integrase core domain; Region: rve; pfam00665 1117943010110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943010111 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1117943010112 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1117943010113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943010114 Walker A motif; other site 1117943010115 ATP binding site [chemical binding]; other site 1117943010116 Walker B motif; other site 1117943010117 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1117943010118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943010119 Integrase core domain; Region: rve; pfam00665 1117943010120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943010121 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1117943010122 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1117943010123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943010124 Walker A motif; other site 1117943010125 ATP binding site [chemical binding]; other site 1117943010126 Walker B motif; other site 1117943010127 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1117943010128 Transposase domain (DUF772); Region: DUF772; pfam05598 1117943010129 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1117943010130 two-component response regulator; Provisional; Region: PRK09191 1117943010131 CsbD-like; Region: CsbD; cl17424 1117943010132 potential frameshift: common BLAST hit: gi|15890129|ref|NP_355801.1| IS21 family transposase 1117943010133 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1117943010134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1117943010135 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1117943010136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943010137 Walker A motif; other site 1117943010138 ATP binding site [chemical binding]; other site 1117943010139 Walker B motif; other site 1117943010140 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943010141 Integrase core domain; Region: rve; pfam00665 1117943010142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943010143 Walker A/P-loop; other site 1117943010144 ATP binding site [chemical binding]; other site 1117943010145 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 1117943010146 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 1117943010147 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1117943010148 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943010149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943010150 non-specific DNA binding site [nucleotide binding]; other site 1117943010151 salt bridge; other site 1117943010152 sequence-specific DNA binding site [nucleotide binding]; other site 1117943010153 Domain of unknown function (DUF955); Region: DUF955; cl01076 1117943010154 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 1117943010155 HTH DNA binding domain; Region: HTH_13; pfam11972 1117943010156 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943010157 active site 1117943010158 DNA binding site [nucleotide binding] 1117943010159 Int/Topo IB signature motif; other site 1117943010160 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1117943010161 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1117943010162 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1117943010163 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1117943010164 catalytic residues [active] 1117943010165 catalytic nucleophile [active] 1117943010166 Presynaptic Site I dimer interface [polypeptide binding]; other site 1117943010167 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1117943010168 Synaptic Flat tetramer interface [polypeptide binding]; other site 1117943010169 Synaptic Site I dimer interface [polypeptide binding]; other site 1117943010170 DNA binding site [nucleotide binding] 1117943010171 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1117943010172 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1117943010173 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1117943010174 Trypsin; Region: Trypsin; pfam00089 1117943010175 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943010176 protein binding site [polypeptide binding]; other site 1117943010177 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943010178 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1117943010179 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1117943010180 ring oligomerisation interface [polypeptide binding]; other site 1117943010181 ATP/Mg binding site [chemical binding]; other site 1117943010182 stacking interactions; other site 1117943010183 hinge regions; other site 1117943010184 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1117943010185 oligomerisation interface [polypeptide binding]; other site 1117943010186 mobile loop; other site 1117943010187 roof hairpin; other site 1117943010188 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1117943010189 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1117943010190 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1117943010191 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1117943010192 putative dimer interface [polypeptide binding]; other site 1117943010193 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 1117943010194 SPW repeat; Region: SPW; pfam03779 1117943010195 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1117943010196 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1117943010197 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1117943010198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943010199 Integrase core domain; Region: rve; pfam00665 1117943010200 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943010201 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1117943010202 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1117943010203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943010204 Walker A motif; other site 1117943010205 ATP binding site [chemical binding]; other site 1117943010206 Walker B motif; other site 1117943010207 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943010208 active site 1117943010209 DNA binding site [nucleotide binding] 1117943010210 Int/Topo IB signature motif; other site 1117943010211 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1117943010212 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1117943010213 ligand binding site [chemical binding]; other site 1117943010214 NAD binding site [chemical binding]; other site 1117943010215 tetramer interface [polypeptide binding]; other site 1117943010216 catalytic site [active] 1117943010217 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1117943010218 L-serine binding site [chemical binding]; other site 1117943010219 ACT domain interface; other site 1117943010220 replication initiation protein RepC; Provisional; Region: PRK13824 1117943010221 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1117943010222 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 1117943010223 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 1117943010224 ParB-like nuclease domain; Region: ParB; smart00470 1117943010225 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 1117943010226 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1117943010227 P-loop; other site 1117943010228 Magnesium ion binding site [ion binding]; other site 1117943010229 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1117943010230 Magnesium ion binding site [ion binding]; other site 1117943010231 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1117943010232 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1117943010233 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1117943010234 Fic/DOC family; Region: Fic; cl00960 1117943010235 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1117943010236 Protein of unknown function (DUF736); Region: DUF736; pfam05284 1117943010237 Staphylococcal nuclease homologues; Region: SNc; smart00318 1117943010238 Catalytic site; other site 1117943010239 Staphylococcal nuclease homologue; Region: SNase; pfam00565 1117943010240 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1117943010241 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 1117943010242 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943010243 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1117943010244 Integrase core domain; Region: rve; pfam00665 1117943010245 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1117943010246 glucan exporter ATP-binding protein; Region: chvA; TIGR01192 1117943010247 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1117943010248 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1117943010249 Walker A/P-loop; other site 1117943010250 ATP binding site [chemical binding]; other site 1117943010251 Q-loop/lid; other site 1117943010252 ABC transporter signature motif; other site 1117943010253 Walker B; other site 1117943010254 D-loop; other site 1117943010255 H-loop/switch region; other site 1117943010256 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1117943010257 OpgC protein; Region: OpgC_C; cl17858 1117943010258 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1117943010259 Putative glucoamylase; Region: Glycoamylase; pfam10091 1117943010260 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 1117943010261 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1117943010262 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 1117943010263 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1117943010264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943010265 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 1117943010266 dimerization interface [polypeptide binding]; other site 1117943010267 substrate binding pocket [chemical binding]; other site 1117943010268 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1117943010269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1117943010270 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1117943010271 FAD binding domain; Region: FAD_binding_4; pfam01565 1117943010272 aldehyde dehydrogenase family 7 member; Region: PLN02315 1117943010273 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1117943010274 tetrameric interface [polypeptide binding]; other site 1117943010275 NAD binding site [chemical binding]; other site 1117943010276 catalytic residues [active] 1117943010277 aspartate aminotransferase; Provisional; Region: PRK05764 1117943010278 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943010279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943010280 homodimer interface [polypeptide binding]; other site 1117943010281 catalytic residue [active] 1117943010282 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943010283 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1117943010284 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943010285 non-specific DNA binding site [nucleotide binding]; other site 1117943010286 salt bridge; other site 1117943010287 sequence-specific DNA binding site [nucleotide binding]; other site 1117943010288 Cupin domain; Region: Cupin_2; pfam07883 1117943010289 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1117943010290 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1117943010291 inhibitor-cofactor binding pocket; inhibition site 1117943010292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943010293 catalytic residue [active] 1117943010294 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1117943010295 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1117943010296 MOFRL family; Region: MOFRL; pfam05161 1117943010297 choline dehydrogenase; Validated; Region: PRK02106 1117943010298 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1117943010299 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 1117943010300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943010301 NAD(P) binding site [chemical binding]; other site 1117943010302 active site 1117943010303 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1117943010304 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1117943010305 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1117943010306 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943010307 Walker A/P-loop; other site 1117943010308 ATP binding site [chemical binding]; other site 1117943010309 Q-loop/lid; other site 1117943010310 ABC transporter signature motif; other site 1117943010311 Walker B; other site 1117943010312 D-loop; other site 1117943010313 H-loop/switch region; other site 1117943010314 TOBE domain; Region: TOBE_2; pfam08402 1117943010315 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943010316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943010317 dimer interface [polypeptide binding]; other site 1117943010318 conserved gate region; other site 1117943010319 putative PBP binding loops; other site 1117943010320 ABC-ATPase subunit interface; other site 1117943010321 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1117943010322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943010323 dimer interface [polypeptide binding]; other site 1117943010324 conserved gate region; other site 1117943010325 putative PBP binding loops; other site 1117943010326 ABC-ATPase subunit interface; other site 1117943010327 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943010328 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943010329 Class I aldolases; Region: Aldolase_Class_I; cl17187 1117943010330 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1117943010331 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943010332 DNA binding site [nucleotide binding] 1117943010333 domain linker motif; other site 1117943010334 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1117943010335 ligand binding site [chemical binding]; other site 1117943010336 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1117943010337 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 1117943010338 NAD(P) binding site [chemical binding]; other site 1117943010339 catalytic residues [active] 1117943010340 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1117943010341 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1117943010342 substrate binding site [chemical binding]; other site 1117943010343 oxyanion hole (OAH) forming residues; other site 1117943010344 trimer interface [polypeptide binding]; other site 1117943010345 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1117943010346 Coenzyme A transferase; Region: CoA_trans; smart00882 1117943010347 Coenzyme A transferase; Region: CoA_trans; cl17247 1117943010348 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943010349 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943010350 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1117943010351 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1117943010352 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943010353 DNA binding site [nucleotide binding] 1117943010354 domain linker motif; other site 1117943010355 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1117943010356 putative dimerization interface [polypeptide binding]; other site 1117943010357 putative ligand binding site [chemical binding]; other site 1117943010358 Protein of unknown function (DUF993); Region: DUF993; pfam06187 1117943010359 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943010360 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1117943010361 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1117943010362 active site 1117943010363 Zn binding site [ion binding]; other site 1117943010364 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1117943010365 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1117943010366 tartrate dehydrogenase; Region: TTC; TIGR02089 1117943010367 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1117943010368 active site 1117943010369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943010370 putative substrate translocation pore; other site 1117943010371 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1117943010372 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1117943010373 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1117943010374 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1117943010375 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1117943010376 active site clefts [active] 1117943010377 zinc binding site [ion binding]; other site 1117943010378 dimer interface [polypeptide binding]; other site 1117943010379 pyridoxamine kinase; Validated; Region: PRK05756 1117943010380 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1117943010381 pyridoxal binding site [chemical binding]; other site 1117943010382 dimer interface [polypeptide binding]; other site 1117943010383 ATP binding site [chemical binding]; other site 1117943010384 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1117943010385 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1117943010386 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1117943010387 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1117943010388 purine monophosphate binding site [chemical binding]; other site 1117943010389 dimer interface [polypeptide binding]; other site 1117943010390 putative catalytic residues [active] 1117943010391 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1117943010392 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1117943010393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360 1117943010394 NusB family; Region: NusB; pfam01029 1117943010395 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1117943010396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943010397 S-adenosylmethionine binding site [chemical binding]; other site 1117943010398 heat shock protein HtpX; Provisional; Region: PRK01345 1117943010399 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 1117943010400 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 1117943010401 acetyl-CoA synthetase; Provisional; Region: PRK00174 1117943010402 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1117943010403 active site 1117943010404 CoA binding site [chemical binding]; other site 1117943010405 acyl-activating enzyme (AAE) consensus motif; other site 1117943010406 AMP binding site [chemical binding]; other site 1117943010407 acetate binding site [chemical binding]; other site 1117943010408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 1117943010409 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1117943010410 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1117943010411 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943010412 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 1117943010413 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1117943010414 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943010415 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943010416 dimerization interface [polypeptide binding]; other site 1117943010417 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1117943010418 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1117943010419 acyl-activating enzyme (AAE) consensus motif; other site 1117943010420 AMP binding site [chemical binding]; other site 1117943010421 active site 1117943010422 CoA binding site [chemical binding]; other site 1117943010423 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1117943010424 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1117943010425 catalytic residue [active] 1117943010426 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1117943010427 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1117943010428 HIGH motif; other site 1117943010429 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1117943010430 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1117943010431 active site 1117943010432 KMSKS motif; other site 1117943010433 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1117943010434 tRNA binding surface [nucleotide binding]; other site 1117943010435 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468 1117943010436 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 1117943010437 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1117943010438 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1117943010439 ParB-like nuclease domain; Region: ParBc; pfam02195 1117943010440 KorB domain; Region: KorB; pfam08535 1117943010441 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1117943010442 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1117943010443 P-loop; other site 1117943010444 Magnesium ion binding site [ion binding]; other site 1117943010445 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1117943010446 Magnesium ion binding site [ion binding]; other site 1117943010447 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1117943010448 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1117943010449 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1117943010450 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1117943010451 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1117943010452 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1117943010453 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1117943010454 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1117943010455 G1 box; other site 1117943010456 GTP/Mg2+ binding site [chemical binding]; other site 1117943010457 Switch I region; other site 1117943010458 G2 box; other site 1117943010459 Switch II region; other site 1117943010460 G3 box; other site 1117943010461 G4 box; other site 1117943010462 G5 box; other site 1117943010463 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1117943010464 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1117943010465 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1117943010466 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1117943010467 RNA binding site [nucleotide binding]; other site 1117943010468 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1117943010469 multimer interface [polypeptide binding]; other site 1117943010470 Walker A motif; other site 1117943010471 ATP binding site [chemical binding]; other site 1117943010472 Walker B motif; other site 1117943010473 Predicted membrane protein [Function unknown]; Region: COG1981 1117943010474 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1117943010475 substrate binding site [chemical binding]; other site 1117943010476 active site 1117943010477 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1117943010478 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1117943010479 active site 1117943010480 dimer interface [polypeptide binding]; other site 1117943010481 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1117943010482 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1117943010483 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1117943010484 shikimate binding site; other site 1117943010485 NAD(P) binding site [chemical binding]; other site 1117943010486 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1117943010487 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1117943010488 CoA-binding site [chemical binding]; other site 1117943010489 ATP-binding [chemical binding]; other site 1117943010490 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1117943010491 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1117943010492 active site 1117943010493 catalytic site [active] 1117943010494 substrate binding site [chemical binding]; other site 1117943010495 preprotein translocase subunit SecB; Validated; Region: PRK05751 1117943010496 SecA binding site; other site 1117943010497 Preprotein binding site; other site 1117943010498 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1117943010499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 1117943010500 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1117943010501 MltA specific insert domain; Region: MltA; smart00925 1117943010502 3D domain; Region: 3D; pfam06725 1117943010503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1117943010504 Smr domain; Region: Smr; pfam01713 1117943010505 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943010506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943010507 non-specific DNA binding site [nucleotide binding]; other site 1117943010508 salt bridge; other site 1117943010509 sequence-specific DNA binding site [nucleotide binding]; other site 1117943010510 Herpesviridae UL52/UL70 DNA primase; Region: Herpes_UL52; cl17300 1117943010511 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1117943010512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943010513 Mg2+ binding site [ion binding]; other site 1117943010514 G-X-G motif; other site 1117943010515 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1117943010516 anchoring element; other site 1117943010517 dimer interface [polypeptide binding]; other site 1117943010518 ATP binding site [chemical binding]; other site 1117943010519 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1117943010520 active site 1117943010521 putative metal-binding site [ion binding]; other site 1117943010522 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1117943010523 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 1117943010524 putative FMN binding site [chemical binding]; other site 1117943010525 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1117943010526 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1117943010527 tetramerization interface [polypeptide binding]; other site 1117943010528 NAD(P) binding site [chemical binding]; other site 1117943010529 catalytic residues [active] 1117943010530 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1117943010531 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1117943010532 DNA-binding site [nucleotide binding]; DNA binding site 1117943010533 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943010534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1117943010535 DNA-binding site [nucleotide binding]; DNA binding site 1117943010536 FCD domain; Region: FCD; pfam07729 1117943010537 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1117943010538 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1117943010539 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1117943010540 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1117943010541 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1117943010542 active site 1117943010543 catalytic tetrad [active] 1117943010544 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 1117943010545 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1117943010546 putative ligand binding site [chemical binding]; other site 1117943010547 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1117943010548 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1117943010549 Walker A/P-loop; other site 1117943010550 ATP binding site [chemical binding]; other site 1117943010551 Q-loop/lid; other site 1117943010552 ABC transporter signature motif; other site 1117943010553 Walker B; other site 1117943010554 D-loop; other site 1117943010555 H-loop/switch region; other site 1117943010556 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1117943010557 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943010558 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943010559 TM-ABC transporter signature motif; other site 1117943010560 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1117943010561 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1117943010562 putative NAD(P) binding site [chemical binding]; other site 1117943010563 catalytic Zn binding site [ion binding]; other site 1117943010564 structural Zn binding site [ion binding]; other site 1117943010565 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1117943010566 Amidohydrolase; Region: Amidohydro_2; pfam04909 1117943010567 active site 1117943010568 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 1117943010569 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1117943010570 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 1117943010571 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1117943010572 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1117943010573 active site 1117943010574 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1117943010575 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1117943010576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943010577 catalytic residue [active] 1117943010578 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1117943010579 substrate binding site [chemical binding]; other site 1117943010580 active site 1117943010581 catalytic residues [active] 1117943010582 heterodimer interface [polypeptide binding]; other site 1117943010583 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1117943010584 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1117943010585 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1117943010586 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1117943010587 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1117943010588 catalytic residues [active] 1117943010589 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 1117943010590 Part of AAA domain; Region: AAA_19; pfam13245 1117943010591 Family description; Region: UvrD_C_2; pfam13538 1117943010592 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1117943010593 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 1117943010594 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1117943010595 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1117943010596 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1117943010597 Substrate binding site; other site 1117943010598 metal-binding site 1117943010599 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1117943010600 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1117943010601 Phosphotransferase enzyme family; Region: APH; pfam01636 1117943010602 PAS fold; Region: PAS_7; pfam12860 1117943010603 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1117943010604 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943010605 dimer interface [polypeptide binding]; other site 1117943010606 phosphorylation site [posttranslational modification] 1117943010607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943010608 ATP binding site [chemical binding]; other site 1117943010609 Mg2+ binding site [ion binding]; other site 1117943010610 G-X-G motif; other site 1117943010611 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1117943010612 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1117943010613 homotetramer interface [polypeptide binding]; other site 1117943010614 ligand binding site [chemical binding]; other site 1117943010615 catalytic site [active] 1117943010616 NAD binding site [chemical binding]; other site 1117943010617 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1117943010618 dimerization domain swap beta strand [polypeptide binding]; other site 1117943010619 regulatory protein interface [polypeptide binding]; other site 1117943010620 active site 1117943010621 regulatory phosphorylation site [posttranslational modification]; other site 1117943010622 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1117943010623 active pocket/dimerization site; other site 1117943010624 active site 1117943010625 phosphorylation site [posttranslational modification] 1117943010626 Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493 1117943010627 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1117943010628 Hpr binding site; other site 1117943010629 active site 1117943010630 homohexamer subunit interaction site [polypeptide binding]; other site 1117943010631 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 1117943010632 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 1117943010633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943010634 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943010635 dimerization interface [polypeptide binding]; other site 1117943010636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943010637 dimer interface [polypeptide binding]; other site 1117943010638 phosphorylation site [posttranslational modification] 1117943010639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943010640 ATP binding site [chemical binding]; other site 1117943010641 Mg2+ binding site [ion binding]; other site 1117943010642 G-X-G motif; other site 1117943010643 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1117943010644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943010645 active site 1117943010646 phosphorylation site [posttranslational modification] 1117943010647 intermolecular recognition site; other site 1117943010648 dimerization interface [polypeptide binding]; other site 1117943010649 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943010650 DNA binding site [nucleotide binding] 1117943010651 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1117943010652 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1117943010653 active site 1117943010654 substrate-binding site [chemical binding]; other site 1117943010655 metal-binding site [ion binding] 1117943010656 ATP binding site [chemical binding]; other site 1117943010657 hypothetical protein; Provisional; Region: PRK09256 1117943010658 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1117943010659 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1117943010660 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1117943010661 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1117943010662 pantothenate kinase; Provisional; Region: PRK05439 1117943010663 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1117943010664 ATP-binding site [chemical binding]; other site 1117943010665 CoA-binding site [chemical binding]; other site 1117943010666 Mg2+-binding site [ion binding]; other site 1117943010667 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1117943010668 metal binding site [ion binding]; metal-binding site 1117943010669 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1117943010670 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1117943010671 substrate binding site [chemical binding]; other site 1117943010672 glutamase interaction surface [polypeptide binding]; other site 1117943010673 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1117943010674 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1117943010675 catalytic residues [active] 1117943010676 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1117943010677 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1117943010678 putative active site [active] 1117943010679 oxyanion strand; other site 1117943010680 catalytic triad [active] 1117943010681 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1117943010682 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1117943010683 putative active site pocket [active] 1117943010684 4-fold oligomerization interface [polypeptide binding]; other site 1117943010685 metal binding residues [ion binding]; metal-binding site 1117943010686 3-fold/trimer interface [polypeptide binding]; other site 1117943010687 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1117943010688 active site 1117943010689 HslU subunit interaction site [polypeptide binding]; other site 1117943010690 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1117943010691 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1117943010692 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1117943010693 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1117943010694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943010695 Walker A motif; other site 1117943010696 ATP binding site [chemical binding]; other site 1117943010697 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1117943010698 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1117943010699 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 1117943010700 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1117943010701 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1117943010702 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1117943010703 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1117943010704 active site 1117943010705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1117943010706 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1117943010707 Protein of unknown function (DUF1052); Region: DUF1052; pfam06319 1117943010708 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1117943010709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943010710 active site 1117943010711 phosphorylation site [posttranslational modification] 1117943010712 intermolecular recognition site; other site 1117943010713 dimerization interface [polypeptide binding]; other site 1117943010714 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1117943010715 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943010716 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943010717 dimer interface [polypeptide binding]; other site 1117943010718 phosphorylation site [posttranslational modification] 1117943010719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943010720 ATP binding site [chemical binding]; other site 1117943010721 Mg2+ binding site [ion binding]; other site 1117943010722 G-X-G motif; other site 1117943010723 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 1117943010724 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1117943010725 ATP binding site [chemical binding]; other site 1117943010726 putative Mg++ binding site [ion binding]; other site 1117943010727 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1117943010728 nucleotide binding region [chemical binding]; other site 1117943010729 ATP-binding site [chemical binding]; other site 1117943010730 Helicase associated domain (HA2); Region: HA2; pfam04408 1117943010731 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1117943010732 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 1117943010733 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943010734 Walker A/P-loop; other site 1117943010735 ATP binding site [chemical binding]; other site 1117943010736 Q-loop/lid; other site 1117943010737 ABC transporter signature motif; other site 1117943010738 Walker B; other site 1117943010739 D-loop; other site 1117943010740 H-loop/switch region; other site 1117943010741 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 1117943010742 hypothetical protein; Provisional; Region: PRK11622 1117943010743 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1117943010744 ornithine cyclodeaminase; Validated; Region: PRK06141 1117943010745 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1117943010746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 1117943010747 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1117943010748 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1117943010749 active site 1117943010750 TDP-binding site; other site 1117943010751 acceptor substrate-binding pocket; other site 1117943010752 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1117943010753 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943010754 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943010755 dimerization interface [polypeptide binding]; other site 1117943010756 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1117943010757 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1117943010758 metal binding site [ion binding]; metal-binding site 1117943010759 substrate binding pocket [chemical binding]; other site 1117943010760 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 1117943010761 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 1117943010762 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 1117943010763 dimer interface [polypeptide binding]; other site 1117943010764 active site 1117943010765 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1117943010766 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 1117943010767 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1117943010768 putative alpha subunit interface [polypeptide binding]; other site 1117943010769 putative active site [active] 1117943010770 putative substrate binding site [chemical binding]; other site 1117943010771 Fe binding site [ion binding]; other site 1117943010772 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1117943010773 inter-subunit interface; other site 1117943010774 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1117943010775 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1117943010776 catalytic loop [active] 1117943010777 iron binding site [ion binding]; other site 1117943010778 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1117943010779 FAD binding pocket [chemical binding]; other site 1117943010780 FAD binding motif [chemical binding]; other site 1117943010781 phosphate binding motif [ion binding]; other site 1117943010782 beta-alpha-beta structure motif; other site 1117943010783 NAD binding pocket [chemical binding]; other site 1117943010784 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 1117943010785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943010786 NAD(P) binding site [chemical binding]; other site 1117943010787 active site 1117943010788 benzoate transport; Region: 2A0115; TIGR00895 1117943010789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943010790 putative substrate translocation pore; other site 1117943010791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943010792 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1117943010793 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1117943010794 transmembrane helices; other site 1117943010795 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1117943010796 TrkA-C domain; Region: TrkA_C; pfam02080 1117943010797 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1117943010798 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1117943010799 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1117943010800 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1117943010801 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1117943010802 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943010803 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943010804 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1117943010805 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 1117943010806 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1117943010807 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1117943010808 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1117943010809 dimerization interface [polypeptide binding]; other site 1117943010810 metal binding site [ion binding]; metal-binding site 1117943010811 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1117943010812 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1117943010813 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1117943010814 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1117943010815 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1117943010816 ligand binding site [chemical binding]; other site 1117943010817 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943010818 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1117943010819 TM-ABC transporter signature motif; other site 1117943010820 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1117943010821 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1117943010822 TM-ABC transporter signature motif; other site 1117943010823 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1117943010824 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1117943010825 Walker A/P-loop; other site 1117943010826 ATP binding site [chemical binding]; other site 1117943010827 Q-loop/lid; other site 1117943010828 ABC transporter signature motif; other site 1117943010829 Walker B; other site 1117943010830 D-loop; other site 1117943010831 H-loop/switch region; other site 1117943010832 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1117943010833 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1117943010834 Walker A/P-loop; other site 1117943010835 ATP binding site [chemical binding]; other site 1117943010836 Q-loop/lid; other site 1117943010837 ABC transporter signature motif; other site 1117943010838 Walker B; other site 1117943010839 D-loop; other site 1117943010840 H-loop/switch region; other site 1117943010841 aspartate aminotransferase; Provisional; Region: PRK06107 1117943010842 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943010843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943010844 homodimer interface [polypeptide binding]; other site 1117943010845 catalytic residue [active] 1117943010846 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1117943010847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943010848 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1117943010849 putative dimerization interface [polypeptide binding]; other site 1117943010850 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1117943010851 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1117943010852 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1117943010853 catalytic residue [active] 1117943010854 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1117943010855 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1117943010856 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1117943010857 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1117943010858 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1117943010859 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1117943010860 classical (c) SDRs; Region: SDR_c; cd05233 1117943010861 NAD(P) binding site [chemical binding]; other site 1117943010862 active site 1117943010863 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1117943010864 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943010865 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943010866 dimer interface [polypeptide binding]; other site 1117943010867 phosphorylation site [posttranslational modification] 1117943010868 Response regulator receiver domain; Region: Response_reg; pfam00072 1117943010869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943010870 active site 1117943010871 phosphorylation site [posttranslational modification] 1117943010872 intermolecular recognition site; other site 1117943010873 dimerization interface [polypeptide binding]; other site 1117943010874 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1117943010875 cyclase homology domain; Region: CHD; cd07302 1117943010876 nucleotidyl binding site; other site 1117943010877 metal binding site [ion binding]; metal-binding site 1117943010878 dimer interface [polypeptide binding]; other site 1117943010879 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1117943010880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943010881 active site 1117943010882 phosphorylation site [posttranslational modification] 1117943010883 intermolecular recognition site; other site 1117943010884 dimerization interface [polypeptide binding]; other site 1117943010885 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943010886 dimerization interface [polypeptide binding]; other site 1117943010887 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1117943010888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943010889 putative active site [active] 1117943010890 heme pocket [chemical binding]; other site 1117943010891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943010892 dimer interface [polypeptide binding]; other site 1117943010893 phosphorylation site [posttranslational modification] 1117943010894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943010895 ATP binding site [chemical binding]; other site 1117943010896 Mg2+ binding site [ion binding]; other site 1117943010897 G-X-G motif; other site 1117943010898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943010899 Response regulator receiver domain; Region: Response_reg; pfam00072 1117943010900 active site 1117943010901 phosphorylation site [posttranslational modification] 1117943010902 intermolecular recognition site; other site 1117943010903 dimerization interface [polypeptide binding]; other site 1117943010904 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1117943010905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943010906 active site 1117943010907 phosphorylation site [posttranslational modification] 1117943010908 intermolecular recognition site; other site 1117943010909 dimerization interface [polypeptide binding]; other site 1117943010910 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1117943010911 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 1117943010912 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1117943010913 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943010914 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1117943010915 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943010916 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1117943010917 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1117943010918 Walker A/P-loop; other site 1117943010919 ATP binding site [chemical binding]; other site 1117943010920 Q-loop/lid; other site 1117943010921 ABC transporter signature motif; other site 1117943010922 Walker B; other site 1117943010923 D-loop; other site 1117943010924 H-loop/switch region; other site 1117943010925 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1117943010926 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943010927 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1117943010928 TM-ABC transporter signature motif; other site 1117943010929 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943010930 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1117943010931 TM-ABC transporter signature motif; other site 1117943010932 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1117943010933 active site 1117943010934 catalytic motif [active] 1117943010935 Zn binding site [ion binding]; other site 1117943010936 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1117943010937 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1117943010938 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1117943010939 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1117943010940 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1117943010941 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1117943010942 catalytic motif [active] 1117943010943 Catalytic residue [active] 1117943010944 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1117943010945 active site 1117943010946 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1117943010947 adenosine deaminase; Provisional; Region: PRK09358 1117943010948 active site 1117943010949 phosphopentomutase; Provisional; Region: PRK05362 1117943010950 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1117943010951 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1117943010952 TadE-like protein; Region: TadE; pfam07811 1117943010953 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1117943010954 TadE-like protein; Region: TadE; pfam07811 1117943010955 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1117943010956 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 1117943010957 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 1117943010958 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1117943010959 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1117943010960 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1117943010961 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1117943010962 BON domain; Region: BON; pfam04972 1117943010963 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1117943010964 Type IV pili component [Cell motility and secretion]; Region: COG5461 1117943010965 pilus (Caulobacter type) biogenesis lipoprotein CpaD; Region: pilus_cpaD; TIGR02522 1117943010966 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 1117943010967 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1117943010968 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1117943010969 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1117943010970 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1117943010971 ATP binding site [chemical binding]; other site 1117943010972 Walker A motif; other site 1117943010973 hexamer interface [polypeptide binding]; other site 1117943010974 Walker B motif; other site 1117943010975 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1117943010976 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1117943010977 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1117943010978 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1117943010979 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1117943010980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 1117943010981 putative active site [active] 1117943010982 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 1117943010983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943010984 TPR motif; other site 1117943010985 binding surface 1117943010986 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1117943010987 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1117943010988 interface (dimer of trimers) [polypeptide binding]; other site 1117943010989 Substrate-binding/catalytic site; other site 1117943010990 Zn-binding sites [ion binding]; other site 1117943010991 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1117943010992 MarR family; Region: MarR_2; pfam12802 1117943010993 Bacterial SH3 domain; Region: SH3_3; cl17532 1117943010994 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1117943010995 NlpC/P60 family; Region: NLPC_P60; cl17555 1117943010996 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1117943010997 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1117943010998 putative ligand binding site [chemical binding]; other site 1117943010999 NAD binding site [chemical binding]; other site 1117943011000 dimerization interface [polypeptide binding]; other site 1117943011001 catalytic site [active] 1117943011002 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1117943011003 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943011004 Walker A/P-loop; other site 1117943011005 ATP binding site [chemical binding]; other site 1117943011006 Q-loop/lid; other site 1117943011007 ABC transporter signature motif; other site 1117943011008 Walker B; other site 1117943011009 D-loop; other site 1117943011010 H-loop/switch region; other site 1117943011011 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1117943011012 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943011013 Walker A/P-loop; other site 1117943011014 ATP binding site [chemical binding]; other site 1117943011015 Q-loop/lid; other site 1117943011016 ABC transporter signature motif; other site 1117943011017 Walker B; other site 1117943011018 D-loop; other site 1117943011019 H-loop/switch region; other site 1117943011020 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1117943011021 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1117943011022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943011023 dimer interface [polypeptide binding]; other site 1117943011024 conserved gate region; other site 1117943011025 putative PBP binding loops; other site 1117943011026 ABC-ATPase subunit interface; other site 1117943011027 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1117943011028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943011029 dimer interface [polypeptide binding]; other site 1117943011030 conserved gate region; other site 1117943011031 putative PBP binding loops; other site 1117943011032 ABC-ATPase subunit interface; other site 1117943011033 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1117943011034 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1117943011035 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1117943011036 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1117943011037 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1117943011038 active site 1117943011039 dimer interfaces [polypeptide binding]; other site 1117943011040 catalytic residues [active] 1117943011041 glucokinase; Provisional; Region: glk; PRK00292 1117943011042 glucokinase, proteobacterial type; Region: glk; TIGR00749 1117943011043 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1117943011044 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1117943011045 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 1117943011046 Walker A/P-loop; other site 1117943011047 ATP binding site [chemical binding]; other site 1117943011048 Q-loop/lid; other site 1117943011049 ABC transporter signature motif; other site 1117943011050 Walker B; other site 1117943011051 D-loop; other site 1117943011052 H-loop/switch region; other site 1117943011053 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1117943011054 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1117943011055 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1117943011056 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1117943011057 catalytic core [active] 1117943011058 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943011059 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943011060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943011061 Integrase core domain; Region: rve; pfam00665 1117943011062 transposase/IS protein; Provisional; Region: PRK09183 1117943011063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943011064 Walker A motif; other site 1117943011065 ATP binding site [chemical binding]; other site 1117943011066 Walker B motif; other site 1117943011067 arginine finger; other site 1117943011068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943011069 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943011070 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943011071 Helix-turn-helix domain; Region: HTH_28; pfam13518 1117943011072 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943011073 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943011074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943011075 Helix-turn-helix domain; Region: HTH_18; pfam12833 1117943011076 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1117943011077 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1117943011078 DNA binding site [nucleotide binding] 1117943011079 active site 1117943011080 Integral membrane protein [Function unknown]; Region: COG5488 1117943011081 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1117943011082 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1117943011083 minor groove reading motif; other site 1117943011084 helix-hairpin-helix signature motif; other site 1117943011085 substrate binding pocket [chemical binding]; other site 1117943011086 active site 1117943011087 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1117943011088 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1117943011089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943011090 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1117943011091 putative dimer interface [polypeptide binding]; other site 1117943011092 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943011093 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 1117943011094 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1117943011095 substrate binding site [chemical binding]; other site 1117943011096 ATP binding site [chemical binding]; other site 1117943011097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 1117943011098 Bacterial SH3 domain; Region: SH3_4; pfam06347 1117943011099 Bacterial SH3 domain; Region: SH3_4; pfam06347 1117943011100 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1117943011101 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1117943011102 dimerization interface [polypeptide binding]; other site 1117943011103 ligand binding site [chemical binding]; other site 1117943011104 NADP binding site [chemical binding]; other site 1117943011105 catalytic site [active] 1117943011106 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1117943011107 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1117943011108 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943011109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943011110 Coenzyme A binding pocket [chemical binding]; other site 1117943011111 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1117943011112 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1117943011113 ATP binding site [chemical binding]; other site 1117943011114 substrate interface [chemical binding]; other site 1117943011115 recombination protein F; Reviewed; Region: recF; PRK00064 1117943011116 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1117943011117 Walker A/P-loop; other site 1117943011118 ATP binding site [chemical binding]; other site 1117943011119 Q-loop/lid; other site 1117943011120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943011121 ABC transporter signature motif; other site 1117943011122 Walker B; other site 1117943011123 D-loop; other site 1117943011124 H-loop/switch region; other site 1117943011125 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 1117943011126 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1117943011127 Uncharacterized conserved protein [Function unknown]; Region: COG5588 1117943011128 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 1117943011129 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 1117943011130 chaperone protein DnaJ; Provisional; Region: PRK10767 1117943011131 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1117943011132 HSP70 interaction site [polypeptide binding]; other site 1117943011133 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1117943011134 substrate binding site [polypeptide binding]; other site 1117943011135 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1117943011136 Zn binding sites [ion binding]; other site 1117943011137 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1117943011138 dimer interface [polypeptide binding]; other site 1117943011139 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1117943011140 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 1117943011141 nucleotide binding site [chemical binding]; other site 1117943011142 NEF interaction site [polypeptide binding]; other site 1117943011143 SBD interface [polypeptide binding]; other site 1117943011144 Transglycosylase; Region: Transgly; pfam00912 1117943011145 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1117943011146 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1117943011147 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 1117943011148 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1117943011149 EamA-like transporter family; Region: EamA; pfam00892 1117943011150 EamA-like transporter family; Region: EamA; pfam00892 1117943011151 Predicted integral membrane protein [Function unknown]; Region: COG0392 1117943011152 hypothetical protein; Validated; Region: PRK09104 1117943011153 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 1117943011154 metal binding site [ion binding]; metal-binding site 1117943011155 putative dimer interface [polypeptide binding]; other site 1117943011156 MarR family; Region: MarR; pfam01047 1117943011157 5'-3' exonuclease; Region: 53EXOc; smart00475 1117943011158 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1117943011159 active site 1117943011160 metal binding site 1 [ion binding]; metal-binding site 1117943011161 putative 5' ssDNA interaction site; other site 1117943011162 metal binding site 3; metal-binding site 1117943011163 metal binding site 2 [ion binding]; metal-binding site 1117943011164 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1117943011165 putative DNA binding site [nucleotide binding]; other site 1117943011166 putative metal binding site [ion binding]; other site 1117943011167 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 1117943011168 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1117943011169 active site 1117943011170 catalytic site [active] 1117943011171 substrate binding site [chemical binding]; other site 1117943011172 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1117943011173 active site 1117943011174 DNA binding site [nucleotide binding] 1117943011175 catalytic site [active] 1117943011176 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943011177 cyclase homology domain; Region: CHD; cd07302 1117943011178 nucleotidyl binding site; other site 1117943011179 metal binding site [ion binding]; metal-binding site 1117943011180 dimer interface [polypeptide binding]; other site 1117943011181 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1117943011182 catalytic core [active] 1117943011183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1117943011184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943011185 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1117943011186 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1117943011187 Protein export membrane protein; Region: SecD_SecF; cl14618 1117943011188 Protein export membrane protein; Region: SecD_SecF; cl14618 1117943011189 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 1117943011190 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1117943011191 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943011192 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1117943011193 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943011194 Walker A/P-loop; other site 1117943011195 ATP binding site [chemical binding]; other site 1117943011196 Q-loop/lid; other site 1117943011197 ABC transporter signature motif; other site 1117943011198 Walker B; other site 1117943011199 D-loop; other site 1117943011200 H-loop/switch region; other site 1117943011201 TOBE domain; Region: TOBE_2; pfam08402 1117943011202 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943011203 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943011204 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943011205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943011206 dimer interface [polypeptide binding]; other site 1117943011207 conserved gate region; other site 1117943011208 putative PBP binding loops; other site 1117943011209 ABC-ATPase subunit interface; other site 1117943011210 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1117943011211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943011212 dimer interface [polypeptide binding]; other site 1117943011213 conserved gate region; other site 1117943011214 putative PBP binding loops; other site 1117943011215 ABC-ATPase subunit interface; other site 1117943011216 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943011217 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943011218 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1117943011219 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1117943011220 putative active site [active] 1117943011221 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 1117943011222 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1117943011223 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943011224 DNA-binding site [nucleotide binding]; DNA binding site 1117943011225 UTRA domain; Region: UTRA; pfam07702 1117943011226 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1117943011227 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1117943011228 dimer interface [polypeptide binding]; other site 1117943011229 active site 1117943011230 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1117943011231 dimer interface [polypeptide binding]; other site 1117943011232 active site 1117943011233 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1117943011234 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1117943011235 active site 1117943011236 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 1117943011237 hypothetical protein; Provisional; Region: PRK06102 1117943011238 Amidase; Region: Amidase; cl11426 1117943011239 CysZ-like protein; Reviewed; Region: PRK12768 1117943011240 hypothetical protein; Provisional; Region: PRK00736 1117943011241 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1117943011242 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1117943011243 ligand binding site [chemical binding]; other site 1117943011244 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1117943011245 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943011246 potential frameshift: common BLAST hit: gi|92117543|ref|YP_577272.1| phage integrase 1117943011247 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943011248 active site 1117943011249 Int/Topo IB signature motif; other site 1117943011250 DNA binding site [nucleotide binding] 1117943011251 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943011252 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1117943011253 DNA binding residues [nucleotide binding] 1117943011254 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 1117943011255 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943011256 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943011257 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943011258 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943011259 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1117943011260 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1117943011261 Sulfatase; Region: Sulfatase; pfam00884 1117943011262 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1117943011263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943011264 active site 1117943011265 phosphorylation site [posttranslational modification] 1117943011266 intermolecular recognition site; other site 1117943011267 dimerization interface [polypeptide binding]; other site 1117943011268 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943011269 DNA binding site [nucleotide binding] 1117943011270 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943011271 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1117943011272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943011273 dimer interface [polypeptide binding]; other site 1117943011274 phosphorylation site [posttranslational modification] 1117943011275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943011276 ATP binding site [chemical binding]; other site 1117943011277 Mg2+ binding site [ion binding]; other site 1117943011278 G-X-G motif; other site 1117943011279 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 1117943011280 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 1117943011281 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1117943011282 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943011283 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943011284 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1117943011285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943011286 dimer interface [polypeptide binding]; other site 1117943011287 conserved gate region; other site 1117943011288 putative PBP binding loops; other site 1117943011289 ABC-ATPase subunit interface; other site 1117943011290 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943011291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943011292 dimer interface [polypeptide binding]; other site 1117943011293 conserved gate region; other site 1117943011294 putative PBP binding loops; other site 1117943011295 ABC-ATPase subunit interface; other site 1117943011296 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1117943011297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943011298 Walker A/P-loop; other site 1117943011299 ATP binding site [chemical binding]; other site 1117943011300 Q-loop/lid; other site 1117943011301 ABC transporter signature motif; other site 1117943011302 Walker B; other site 1117943011303 D-loop; other site 1117943011304 H-loop/switch region; other site 1117943011305 TOBE domain; Region: TOBE_2; pfam08402 1117943011306 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1117943011307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943011308 Walker A/P-loop; other site 1117943011309 ATP binding site [chemical binding]; other site 1117943011310 Q-loop/lid; other site 1117943011311 ABC transporter signature motif; other site 1117943011312 Walker B; other site 1117943011313 D-loop; other site 1117943011314 H-loop/switch region; other site 1117943011315 TOBE domain; Region: TOBE_2; pfam08402 1117943011316 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1117943011317 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 1117943011318 DAK2 domain; Region: Dak2; pfam02734 1117943011319 DAK2 domain; Region: Dak2; cl03685 1117943011320 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1117943011321 active site 1117943011322 active pocket/dimerization site; other site 1117943011323 phosphorylation site [posttranslational modification] 1117943011324 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1117943011325 dimerization domain swap beta strand [polypeptide binding]; other site 1117943011326 regulatory protein interface [polypeptide binding]; other site 1117943011327 active site 1117943011328 regulatory phosphorylation site [posttranslational modification]; other site 1117943011329 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1117943011330 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1117943011331 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1117943011332 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1117943011333 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1117943011334 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1117943011335 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1117943011336 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1117943011337 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1117943011338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943011339 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1117943011340 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943011341 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1117943011342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943011343 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1117943011344 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1117943011345 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1117943011346 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1117943011347 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943011348 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1117943011349 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 1117943011350 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943011351 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943011352 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1117943011353 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1117943011354 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1117943011355 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1117943011356 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1117943011357 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943011358 active site 1117943011359 metal binding site [ion binding]; metal-binding site 1117943011360 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943011361 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1117943011362 active site 1117943011363 metal binding site [ion binding]; metal-binding site 1117943011364 AMP-binding domain protein; Validated; Region: PRK07529 1117943011365 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1117943011366 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 1117943011367 acyl-activating enzyme (AAE) consensus motif; other site 1117943011368 putative AMP binding site [chemical binding]; other site 1117943011369 putative active site [active] 1117943011370 putative CoA binding site [chemical binding]; other site 1117943011371 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1117943011372 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1117943011373 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1117943011374 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1117943011375 molybdopterin cofactor binding site; other site 1117943011376 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1117943011377 molybdopterin cofactor binding site; other site 1117943011378 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 1117943011379 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1117943011380 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1117943011381 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1117943011382 Walker A/P-loop; other site 1117943011383 ATP binding site [chemical binding]; other site 1117943011384 Q-loop/lid; other site 1117943011385 ABC transporter signature motif; other site 1117943011386 Walker B; other site 1117943011387 D-loop; other site 1117943011388 H-loop/switch region; other site 1117943011389 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1117943011390 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1117943011391 dimer interface [polypeptide binding]; other site 1117943011392 active site 1117943011393 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943011394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943011395 non-specific DNA binding site [nucleotide binding]; other site 1117943011396 salt bridge; other site 1117943011397 sequence-specific DNA binding site [nucleotide binding]; other site 1117943011398 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 1117943011399 nudix motif; other site 1117943011400 HAMP domain; Region: HAMP; pfam00672 1117943011401 dimerization interface [polypeptide binding]; other site 1117943011402 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1117943011403 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1117943011404 dimer interface [polypeptide binding]; other site 1117943011405 putative CheW interface [polypeptide binding]; other site 1117943011406 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1117943011407 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1117943011408 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1117943011409 putative active site [active] 1117943011410 putative metal binding residues [ion binding]; other site 1117943011411 signature motif; other site 1117943011412 putative triphosphate binding site [ion binding]; other site 1117943011413 CHAD domain; Region: CHAD; pfam05235 1117943011414 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1117943011415 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1117943011416 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943011417 Walker A/P-loop; other site 1117943011418 ATP binding site [chemical binding]; other site 1117943011419 Q-loop/lid; other site 1117943011420 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1117943011421 ABC transporter signature motif; other site 1117943011422 Walker B; other site 1117943011423 D-loop; other site 1117943011424 ABC transporter; Region: ABC_tran_2; pfam12848 1117943011425 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1117943011426 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1117943011427 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 1117943011428 putative hydrophobic ligand binding site [chemical binding]; other site 1117943011429 BON domain; Region: BON; pfam04972 1117943011430 Predicted permeases [General function prediction only]; Region: COG0679 1117943011431 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1117943011432 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943011433 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1117943011434 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1117943011435 homodimer interface [polypeptide binding]; other site 1117943011436 substrate-cofactor binding pocket; other site 1117943011437 catalytic residue [active] 1117943011438 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1117943011439 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1117943011440 Ligand binding site; other site 1117943011441 oligomer interface; other site 1117943011442 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1117943011443 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 1117943011444 putative dimer interface [polypeptide binding]; other site 1117943011445 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943011446 Predicted transcriptional regulator [Transcription]; Region: COG2378 1117943011447 HTH domain; Region: HTH_11; pfam08279 1117943011448 WYL domain; Region: WYL; pfam13280 1117943011449 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1117943011450 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1117943011451 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1117943011452 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1117943011453 putative NADH binding site [chemical binding]; other site 1117943011454 putative active site [active] 1117943011455 nudix motif; other site 1117943011456 putative metal binding site [ion binding]; other site 1117943011457 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 1117943011458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943011459 Walker A motif; other site 1117943011460 ATP binding site [chemical binding]; other site 1117943011461 Walker B motif; other site 1117943011462 arginine finger; other site 1117943011463 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1117943011464 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 1117943011465 hypothetical protein; Validated; Region: PRK00153 1117943011466 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1117943011467 recombination protein RecR; Reviewed; Region: recR; PRK00076 1117943011468 RecR protein; Region: RecR; pfam02132 1117943011469 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1117943011470 putative active site [active] 1117943011471 putative metal-binding site [ion binding]; other site 1117943011472 tetramer interface [polypeptide binding]; other site 1117943011473 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1117943011474 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1117943011475 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1117943011476 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1117943011477 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1117943011478 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1117943011479 ligand binding site [chemical binding]; other site 1117943011480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1117943011481 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1117943011482 Transmembrane secretion effector; Region: MFS_3; pfam05977 1117943011483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943011484 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1117943011485 Sm and related proteins; Region: Sm_like; cl00259 1117943011486 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1117943011487 putative oligomer interface [polypeptide binding]; other site 1117943011488 putative RNA binding site [nucleotide binding]; other site 1117943011489 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1117943011490 NusA N-terminal domain; Region: NusA_N; pfam08529 1117943011491 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1117943011492 RNA binding site [nucleotide binding]; other site 1117943011493 homodimer interface [polypeptide binding]; other site 1117943011494 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1117943011495 G-X-X-G motif; other site 1117943011496 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1117943011497 G-X-X-G motif; other site 1117943011498 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1117943011499 hypothetical protein; Provisional; Region: PRK09190 1117943011500 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1117943011501 putative RNA binding cleft [nucleotide binding]; other site 1117943011502 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1117943011503 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1117943011504 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1117943011505 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1117943011506 G1 box; other site 1117943011507 putative GEF interaction site [polypeptide binding]; other site 1117943011508 GTP/Mg2+ binding site [chemical binding]; other site 1117943011509 Switch I region; other site 1117943011510 G2 box; other site 1117943011511 G3 box; other site 1117943011512 Switch II region; other site 1117943011513 G4 box; other site 1117943011514 G5 box; other site 1117943011515 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1117943011516 Translation-initiation factor 2; Region: IF-2; pfam11987 1117943011517 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1117943011518 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1117943011519 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 1117943011520 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1117943011521 RNA binding site [nucleotide binding]; other site 1117943011522 active site 1117943011523 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1117943011524 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1117943011525 HWE histidine kinase; Region: HWE_HK; pfam07536 1117943011526 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1117943011527 16S/18S rRNA binding site [nucleotide binding]; other site 1117943011528 S13e-L30e interaction site [polypeptide binding]; other site 1117943011529 25S rRNA binding site [nucleotide binding]; other site 1117943011530 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1117943011531 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1117943011532 RNase E interface [polypeptide binding]; other site 1117943011533 trimer interface [polypeptide binding]; other site 1117943011534 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1117943011535 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1117943011536 RNase E interface [polypeptide binding]; other site 1117943011537 trimer interface [polypeptide binding]; other site 1117943011538 active site 1117943011539 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1117943011540 putative nucleic acid binding region [nucleotide binding]; other site 1117943011541 G-X-X-G motif; other site 1117943011542 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1117943011543 RNA binding site [nucleotide binding]; other site 1117943011544 domain interface; other site 1117943011545 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1117943011546 Methyltransferase small domain; Region: MTS; pfam05175 1117943011547 S-adenosylmethionine binding site [chemical binding]; other site 1117943011548 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1117943011549 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1117943011550 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943011551 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 1117943011552 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1117943011553 NAD binding site [chemical binding]; other site 1117943011554 homotetramer interface [polypeptide binding]; other site 1117943011555 homodimer interface [polypeptide binding]; other site 1117943011556 substrate binding site [chemical binding]; other site 1117943011557 active site 1117943011558 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1117943011559 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1117943011560 dimer interface [polypeptide binding]; other site 1117943011561 active site 1117943011562 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1117943011563 active site 1 [active] 1117943011564 dimer interface [polypeptide binding]; other site 1117943011565 active site 2 [active] 1117943011566 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1117943011567 metal binding site 2 [ion binding]; metal-binding site 1117943011568 putative DNA binding helix; other site 1117943011569 metal binding site 1 [ion binding]; metal-binding site 1117943011570 dimer interface [polypeptide binding]; other site 1117943011571 Predicted membrane protein [Function unknown]; Region: COG2860 1117943011572 UPF0126 domain; Region: UPF0126; pfam03458 1117943011573 UPF0126 domain; Region: UPF0126; pfam03458 1117943011574 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1117943011575 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1117943011576 putative active site [active] 1117943011577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 1117943011578 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 1117943011579 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1117943011580 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1117943011581 hinge; other site 1117943011582 active site 1117943011583 cytidylate kinase; Provisional; Region: cmk; PRK00023 1117943011584 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1117943011585 CMP-binding site; other site 1117943011586 The sites determining sugar specificity; other site 1117943011587 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1117943011588 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1117943011589 RNA binding site [nucleotide binding]; other site 1117943011590 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1117943011591 RNA binding site [nucleotide binding]; other site 1117943011592 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1117943011593 RNA binding site [nucleotide binding]; other site 1117943011594 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1117943011595 RNA binding site [nucleotide binding]; other site 1117943011596 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1117943011597 RNA binding site [nucleotide binding]; other site 1117943011598 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1117943011599 RNA binding site [nucleotide binding]; other site 1117943011600 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943011601 dimerization interface [polypeptide binding]; other site 1117943011602 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943011603 cyclase homology domain; Region: CHD; cd07302 1117943011604 nucleotidyl binding site; other site 1117943011605 metal binding site [ion binding]; metal-binding site 1117943011606 dimer interface [polypeptide binding]; other site 1117943011607 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 1117943011608 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1117943011609 putative ligand binding site [chemical binding]; other site 1117943011610 putative NAD binding site [chemical binding]; other site 1117943011611 catalytic site [active] 1117943011612 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1117943011613 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1117943011614 putative active site [active] 1117943011615 putative substrate binding site [chemical binding]; other site 1117943011616 catalytic site [active] 1117943011617 Predicted membrane protein [Function unknown]; Region: COG1238 1117943011618 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 1117943011619 Predicted membrane protein [Function unknown]; Region: COG2259 1117943011620 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1117943011621 maltose O-acetyltransferase; Provisional; Region: PRK10092 1117943011622 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1117943011623 active site 1117943011624 substrate binding site [chemical binding]; other site 1117943011625 trimer interface [polypeptide binding]; other site 1117943011626 CoA binding site [chemical binding]; other site 1117943011627 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1117943011628 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1117943011629 Coenzyme A binding pocket [chemical binding]; other site 1117943011630 CcdB protein; Region: CcdB; cl03380 1117943011631 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 1117943011632 GTP-binding protein LepA; Provisional; Region: PRK05433 1117943011633 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1117943011634 G1 box; other site 1117943011635 putative GEF interaction site [polypeptide binding]; other site 1117943011636 GTP/Mg2+ binding site [chemical binding]; other site 1117943011637 Switch I region; other site 1117943011638 G2 box; other site 1117943011639 G3 box; other site 1117943011640 Switch II region; other site 1117943011641 G4 box; other site 1117943011642 G5 box; other site 1117943011643 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1117943011644 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1117943011645 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1117943011646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943011647 putative substrate translocation pore; other site 1117943011648 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943011649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943011650 non-specific DNA binding site [nucleotide binding]; other site 1117943011651 salt bridge; other site 1117943011652 sequence-specific DNA binding site [nucleotide binding]; other site 1117943011653 Cupin domain; Region: Cupin_2; pfam07883 1117943011654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943011655 Coenzyme A binding pocket [chemical binding]; other site 1117943011656 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1117943011657 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1117943011658 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943011659 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1117943011660 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1117943011661 active site 1117943011662 Zn binding site [ion binding]; other site 1117943011663 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 1117943011664 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1117943011665 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1117943011666 ligand binding site [chemical binding]; other site 1117943011667 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1117943011668 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1117943011669 FeS/SAM binding site; other site 1117943011670 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 1117943011671 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1117943011672 motif 1; other site 1117943011673 dimer interface [polypeptide binding]; other site 1117943011674 active site 1117943011675 motif 2; other site 1117943011676 motif 3; other site 1117943011677 elongation factor P; Validated; Region: PRK00529 1117943011678 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1117943011679 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1117943011680 RNA binding site [nucleotide binding]; other site 1117943011681 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1117943011682 RNA binding site [nucleotide binding]; other site 1117943011683 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1117943011684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943011685 S-adenosylmethionine binding site [chemical binding]; other site 1117943011686 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 1117943011687 diiron binding motif [ion binding]; other site 1117943011688 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1117943011689 CCC1-related protein family; Region: CCC1_like_1; cd02437 1117943011690 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 1117943011691 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1117943011692 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1117943011693 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1117943011694 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1117943011695 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1117943011696 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1117943011697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943011698 active site 1117943011699 phosphorylation site [posttranslational modification] 1117943011700 intermolecular recognition site; other site 1117943011701 dimerization interface [polypeptide binding]; other site 1117943011702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943011703 DNA binding site [nucleotide binding] 1117943011704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943011705 ATP binding site [chemical binding]; other site 1117943011706 Mg2+ binding site [ion binding]; other site 1117943011707 G-X-G motif; other site 1117943011708 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1117943011709 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1117943011710 23S rRNA binding site [nucleotide binding]; other site 1117943011711 L21 binding site [polypeptide binding]; other site 1117943011712 L13 binding site [polypeptide binding]; other site 1117943011713 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1117943011714 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1117943011715 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1117943011716 dimer interface [polypeptide binding]; other site 1117943011717 motif 1; other site 1117943011718 active site 1117943011719 motif 2; other site 1117943011720 motif 3; other site 1117943011721 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1117943011722 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1117943011723 putative tRNA-binding site [nucleotide binding]; other site 1117943011724 B3/4 domain; Region: B3_4; pfam03483 1117943011725 tRNA synthetase B5 domain; Region: B5; smart00874 1117943011726 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1117943011727 dimer interface [polypeptide binding]; other site 1117943011728 motif 1; other site 1117943011729 motif 3; other site 1117943011730 motif 2; other site 1117943011731 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 1117943011732 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1117943011733 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943011734 dimer interface [polypeptide binding]; other site 1117943011735 putative metal binding site [ion binding]; other site 1117943011736 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 1117943011737 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1117943011738 dimerization interface [polypeptide binding]; other site 1117943011739 metal binding site [ion binding]; metal-binding site 1117943011740 short chain dehydrogenase; Provisional; Region: PRK07478 1117943011741 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943011742 classical (c) SDRs; Region: SDR_c; cd05233 1117943011743 NAD(P) binding site [chemical binding]; other site 1117943011744 active site 1117943011745 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1117943011746 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1117943011747 active site 1117943011748 catalytic tetrad [active] 1117943011749 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943011750 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943011751 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1117943011752 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1117943011753 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1117943011754 generic binding surface II; other site 1117943011755 generic binding surface I; other site 1117943011756 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1117943011757 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1117943011758 MarR family; Region: MarR_2; cl17246 1117943011759 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1117943011760 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1117943011761 EamA-like transporter family; Region: EamA; pfam00892 1117943011762 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1117943011763 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1117943011764 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1117943011765 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 1117943011766 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1117943011767 N-terminal domain interface [polypeptide binding]; other site 1117943011768 dimer interface [polypeptide binding]; other site 1117943011769 substrate binding pocket (H-site) [chemical binding]; other site 1117943011770 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1117943011771 MarR family; Region: MarR_2; pfam12802 1117943011772 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1117943011773 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1117943011774 putative deacylase active site [active] 1117943011775 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1117943011776 ArsC family; Region: ArsC; pfam03960 1117943011777 putative catalytic residues [active] 1117943011778 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1117943011779 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1117943011780 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1117943011781 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1117943011782 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943011783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943011784 homodimer interface [polypeptide binding]; other site 1117943011785 catalytic residue [active] 1117943011786 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943011787 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943011788 dimerization interface [polypeptide binding]; other site 1117943011789 putative DNA binding site [nucleotide binding]; other site 1117943011790 putative Zn2+ binding site [ion binding]; other site 1117943011791 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943011792 Predicted deacylase [General function prediction only]; Region: COG3608 1117943011793 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1117943011794 active site 1117943011795 Zn binding site [ion binding]; other site 1117943011796 GMP synthase; Reviewed; Region: guaA; PRK00074 1117943011797 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1117943011798 AMP/PPi binding site [chemical binding]; other site 1117943011799 candidate oxyanion hole; other site 1117943011800 catalytic triad [active] 1117943011801 potential glutamine specificity residues [chemical binding]; other site 1117943011802 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1117943011803 ATP Binding subdomain [chemical binding]; other site 1117943011804 Ligand Binding sites [chemical binding]; other site 1117943011805 Dimerization subdomain; other site 1117943011806 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 1117943011807 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026 1117943011808 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1117943011809 CoenzymeA binding site [chemical binding]; other site 1117943011810 subunit interaction site [polypeptide binding]; other site 1117943011811 PHB binding site; other site 1117943011812 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1117943011813 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943011814 Coenzyme A binding pocket [chemical binding]; other site 1117943011815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 1117943011816 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1117943011817 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 1117943011818 Cl binding site [ion binding]; other site 1117943011819 oligomer interface [polypeptide binding]; other site 1117943011820 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG3489 1117943011821 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1117943011822 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1117943011823 Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]; Region: IrpA; COG3487 1117943011824 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1117943011825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943011826 S-adenosylmethionine binding site [chemical binding]; other site 1117943011827 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1117943011828 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1117943011829 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1117943011830 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1117943011831 putative NAD(P) binding site [chemical binding]; other site 1117943011832 epoxyqueuosine reductase; Region: TIGR00276 1117943011833 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1117943011834 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1117943011835 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1117943011836 C-terminal domain interface [polypeptide binding]; other site 1117943011837 GSH binding site (G-site) [chemical binding]; other site 1117943011838 dimer interface [polypeptide binding]; other site 1117943011839 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1117943011840 N-terminal domain interface [polypeptide binding]; other site 1117943011841 dimer interface [polypeptide binding]; other site 1117943011842 substrate binding pocket (H-site) [chemical binding]; other site 1117943011843 Undecaprenyl pyrophosphate phosphatase [Lipid transport and metabolism]; Region: BacA; COG1968 1117943011844 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1117943011845 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1117943011846 putative NAD(P) binding site [chemical binding]; other site 1117943011847 active site 1117943011848 Uncharacterized conserved protein [Function unknown]; Region: COG5470 1117943011849 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1117943011850 active site 1117943011851 dimer interface [polypeptide binding]; other site 1117943011852 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 1117943011853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943011854 S-adenosylmethionine binding site [chemical binding]; other site 1117943011855 DNA polymerase III subunit beta; Validated; Region: PRK05643 1117943011856 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1117943011857 putative DNA binding surface [nucleotide binding]; other site 1117943011858 dimer interface [polypeptide binding]; other site 1117943011859 beta-clamp/clamp loader binding surface; other site 1117943011860 beta-clamp/translesion DNA polymerase binding surface; other site 1117943011861 Predicted methyltransferases [General function prediction only]; Region: COG0313 1117943011862 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1117943011863 putative SAM binding site [chemical binding]; other site 1117943011864 putative homodimer interface [polypeptide binding]; other site 1117943011865 hypothetical protein; Reviewed; Region: PRK12497 1117943011866 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1117943011867 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943011868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943011869 dimer interface [polypeptide binding]; other site 1117943011870 conserved gate region; other site 1117943011871 ABC-ATPase subunit interface; other site 1117943011872 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943011873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943011874 dimer interface [polypeptide binding]; other site 1117943011875 conserved gate region; other site 1117943011876 putative PBP binding loops; other site 1117943011877 ABC-ATPase subunit interface; other site 1117943011878 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1117943011879 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943011880 Walker A/P-loop; other site 1117943011881 ATP binding site [chemical binding]; other site 1117943011882 Q-loop/lid; other site 1117943011883 ABC transporter signature motif; other site 1117943011884 Walker B; other site 1117943011885 D-loop; other site 1117943011886 H-loop/switch region; other site 1117943011887 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1117943011888 putative catalytic site [active] 1117943011889 putative phosphate binding site [ion binding]; other site 1117943011890 putative metal binding site [ion binding]; other site 1117943011891 glutathione synthetase; Provisional; Region: PRK05246 1117943011892 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1117943011893 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1117943011894 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1117943011895 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1117943011896 catalytic residues [active] 1117943011897 catalytic nucleophile [active] 1117943011898 Recombinase; Region: Recombinase; pfam07508 1117943011899 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1117943011900 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1117943011901 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943011902 Integrase core domain; Region: rve; pfam00665 1117943011903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943011904 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1117943011905 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1117943011906 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943011907 Walker A motif; other site 1117943011908 ATP binding site [chemical binding]; other site 1117943011909 Walker B motif; other site 1117943011910 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1117943011911 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1117943011912 catalytic residues [active] 1117943011913 catalytic nucleophile [active] 1117943011914 Recombinase; Region: Recombinase; pfam07508 1117943011915 Divergent AAA domain; Region: AAA_4; pfam04326 1117943011916 Competence protein CoiA-like family; Region: CoiA; cl11541 1117943011917 Protein of unknown function DUF91; Region: DUF91; cl00709 1117943011918 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 1117943011919 hypothetical protein; Provisional; Region: PRK11770 1117943011920 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1117943011921 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1117943011922 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 1117943011923 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1117943011924 active site 1117943011925 AAA ATPase domain; Region: AAA_15; pfam13175 1117943011926 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1117943011927 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1117943011928 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1117943011929 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1117943011930 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1117943011931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943011932 Walker A motif; other site 1117943011933 ATP binding site [chemical binding]; other site 1117943011934 Walker B motif; other site 1117943011935 arginine finger; other site 1117943011936 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1117943011937 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1117943011938 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1117943011939 dimer interface [polypeptide binding]; other site 1117943011940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943011941 catalytic residue [active] 1117943011942 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1117943011943 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1117943011944 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1117943011945 putative active site pocket [active] 1117943011946 dimerization interface [polypeptide binding]; other site 1117943011947 putative catalytic residue [active] 1117943011948 NIPSNAP; Region: NIPSNAP; pfam07978 1117943011949 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1117943011950 EamA-like transporter family; Region: EamA; pfam00892 1117943011951 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943011952 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943011953 putative DNA binding site [nucleotide binding]; other site 1117943011954 putative Zn2+ binding site [ion binding]; other site 1117943011955 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943011956 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1117943011957 active site 1 [active] 1117943011958 dimer interface [polypeptide binding]; other site 1117943011959 hexamer interface [polypeptide binding]; other site 1117943011960 active site 2 [active] 1117943011961 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1117943011962 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943011963 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943011964 dimerization interface [polypeptide binding]; other site 1117943011965 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1117943011966 trimer interface [polypeptide binding]; other site 1117943011967 active site 1117943011968 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1117943011969 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1117943011970 G1 box; other site 1117943011971 putative GEF interaction site [polypeptide binding]; other site 1117943011972 GTP/Mg2+ binding site [chemical binding]; other site 1117943011973 Switch I region; other site 1117943011974 G2 box; other site 1117943011975 G3 box; other site 1117943011976 Switch II region; other site 1117943011977 G4 box; other site 1117943011978 G5 box; other site 1117943011979 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1117943011980 B3/4 domain; Region: B3_4; pfam03483 1117943011981 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1117943011982 EamA-like transporter family; Region: EamA; pfam00892 1117943011983 EamA-like transporter family; Region: EamA; pfam00892 1117943011984 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1117943011985 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1117943011986 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943011987 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943011988 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943011989 non-specific DNA binding site [nucleotide binding]; other site 1117943011990 salt bridge; other site 1117943011991 sequence-specific DNA binding site [nucleotide binding]; other site 1117943011992 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1117943011993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943011994 NAD(P) binding site [chemical binding]; other site 1117943011995 active site 1117943011996 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1117943011997 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1117943011998 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1117943011999 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1117943012000 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1117943012001 dimer interface [polypeptide binding]; other site 1117943012002 PYR/PP interface [polypeptide binding]; other site 1117943012003 TPP binding site [chemical binding]; other site 1117943012004 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1117943012005 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1117943012006 TPP-binding site [chemical binding]; other site 1117943012007 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1117943012008 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1117943012009 substrate binding site [chemical binding]; other site 1117943012010 ATP binding site [chemical binding]; other site 1117943012011 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1117943012012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 1117943012013 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1117943012014 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1117943012015 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1117943012016 putative active site [active] 1117943012017 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943012018 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943012019 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1117943012020 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1117943012021 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1117943012022 putative active site [active] 1117943012023 putative dimer interface [polypeptide binding]; other site 1117943012024 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1117943012025 Flavoprotein; Region: Flavoprotein; pfam02441 1117943012026 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1117943012027 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1117943012028 nucleoside/Zn binding site; other site 1117943012029 dimer interface [polypeptide binding]; other site 1117943012030 catalytic motif [active] 1117943012031 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1117943012032 substrate binding site [chemical binding]; other site 1117943012033 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1117943012034 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943012035 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1117943012036 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943012037 Coenzyme A binding pocket [chemical binding]; other site 1117943012038 ABC1 family; Region: ABC1; cl17513 1117943012039 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1117943012040 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1117943012041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943012042 S-adenosylmethionine binding site [chemical binding]; other site 1117943012043 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1117943012044 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1117943012045 DNA binding site [nucleotide binding] 1117943012046 catalytic residue [active] 1117943012047 H2TH interface [polypeptide binding]; other site 1117943012048 putative catalytic residues [active] 1117943012049 turnover-facilitating residue; other site 1117943012050 intercalation triad [nucleotide binding]; other site 1117943012051 8OG recognition residue [nucleotide binding]; other site 1117943012052 putative reading head residues; other site 1117943012053 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1117943012054 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1117943012055 enoyl-CoA hydratase; Provisional; Region: PRK05862 1117943012056 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1117943012057 substrate binding site [chemical binding]; other site 1117943012058 oxyanion hole (OAH) forming residues; other site 1117943012059 trimer interface [polypeptide binding]; other site 1117943012060 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1117943012061 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1117943012062 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1117943012063 P-loop; other site 1117943012064 Magnesium ion binding site [ion binding]; other site 1117943012065 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1117943012066 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1117943012067 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1117943012068 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1117943012069 catalytic residues [active] 1117943012070 catalytic nucleophile [active] 1117943012071 Presynaptic Site I dimer interface [polypeptide binding]; other site 1117943012072 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1117943012073 Synaptic Flat tetramer interface [polypeptide binding]; other site 1117943012074 Synaptic Site I dimer interface [polypeptide binding]; other site 1117943012075 DNA binding site [nucleotide binding] 1117943012076 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 1117943012077 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1117943012078 Walker A motif; other site 1117943012079 ATP binding site [chemical binding]; other site 1117943012080 Walker B motif; other site 1117943012081 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 1117943012082 MobA/MobL family; Region: MobA_MobL; pfam03389 1117943012083 AAA domain; Region: AAA_30; pfam13604 1117943012084 Family description; Region: UvrD_C_2; pfam13538 1117943012085 Helix-turn-helix domain; Region: HTH_36; pfam13730 1117943012086 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 1117943012087 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943012088 ABC transporter signature motif; other site 1117943012089 Walker B; other site 1117943012090 D-loop; other site 1117943012091 H-loop/switch region; other site 1117943012092 XamI restriction endonuclease; Region: RE_XamI; pfam09572 1117943012093 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1117943012094 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1117943012095 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1117943012096 catalytic residues [active] 1117943012097 catalytic nucleophile [active] 1117943012098 Presynaptic Site I dimer interface [polypeptide binding]; other site 1117943012099 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1117943012100 Synaptic Flat tetramer interface [polypeptide binding]; other site 1117943012101 Synaptic Site I dimer interface [polypeptide binding]; other site 1117943012102 DNA binding site [nucleotide binding] 1117943012103 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1117943012104 DNA-binding interface [nucleotide binding]; DNA binding site 1117943012105 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1117943012106 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1117943012107 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1117943012108 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 1117943012109 ParB-like nuclease domain; Region: ParBc; pfam02195 1117943012110 replication initiation protein RepC; Provisional; Region: PRK13824 1117943012111 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1117943012112 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 1117943012113 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1117943012114 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1117943012115 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1117943012116 DNA binding residues [nucleotide binding] 1117943012117 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1117943012118 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1117943012119 catalytic residues [active] 1117943012120 catalytic nucleophile [active] 1117943012121 Presynaptic Site I dimer interface [polypeptide binding]; other site 1117943012122 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1117943012123 Synaptic Flat tetramer interface [polypeptide binding]; other site 1117943012124 Synaptic Site I dimer interface [polypeptide binding]; other site 1117943012125 DNA binding site [nucleotide binding] 1117943012126 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1117943012127 DNA-binding interface [nucleotide binding]; DNA binding site 1117943012128 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943012129 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943012130 non-specific DNA binding site [nucleotide binding]; other site 1117943012131 salt bridge; other site 1117943012132 sequence-specific DNA binding site [nucleotide binding]; other site 1117943012133 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1117943012134 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1117943012135 P-loop; other site 1117943012136 Magnesium ion binding site [ion binding]; other site 1117943012137 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 1117943012138 AAA domain; Region: AAA_27; pfam13514 1117943012139 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943012140 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943012141 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943012142 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943012143 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943012144 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943012145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1117943012146 Transposase; Region: HTH_Tnp_1; pfam01527 1117943012147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943012148 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943012149 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1117943012150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943012151 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943012152 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943012153 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943012154 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1117943012155 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1117943012156 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1117943012157 catalytic residue [active] 1117943012158 sucrose-6F-phosphate phosphohydrolase; Region: SPP_plant-cyano; TIGR01485 1117943012159 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1117943012160 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1117943012161 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1117943012162 catalytic residue [active] 1117943012163 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1117943012164 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1117943012165 FeS/SAM binding site; other site 1117943012166 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 1117943012167 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1117943012168 Walker A motif; other site 1117943012169 ATP binding site [chemical binding]; other site 1117943012170 Walker B motif; other site 1117943012171 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 1117943012172 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1117943012173 Walker A motif; other site 1117943012174 hexamer interface [polypeptide binding]; other site 1117943012175 ATP binding site [chemical binding]; other site 1117943012176 Walker B motif; other site 1117943012177 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 1117943012178 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1117943012179 VirB7 interaction site; other site 1117943012180 VirB8 protein; Region: VirB8; pfam04335 1117943012181 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 1117943012182 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1117943012183 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1117943012184 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1117943012185 catalytic residue [active] 1117943012186 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 1117943012187 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1117943012188 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 1117943012189 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 1117943012190 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1117943012191 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1117943012192 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1117943012193 catalytic residue [active] 1117943012194 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 1117943012195 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1117943012196 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1117943012197 Staphylococcal nuclease homologues; Region: SNc; smart00318 1117943012198 Catalytic site; other site 1117943012199 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1117943012200 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1117943012201 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1117943012202 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1117943012203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943012204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943012205 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1117943012206 putative effector binding pocket; other site 1117943012207 dimerization interface [polypeptide binding]; other site 1117943012208 Isochorismatase family; Region: Isochorismatase; pfam00857 1117943012209 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1117943012210 catalytic triad [active] 1117943012211 dimer interface [polypeptide binding]; other site 1117943012212 conserved cis-peptide bond; other site 1117943012213 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1117943012214 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943012215 Walker A/P-loop; other site 1117943012216 ATP binding site [chemical binding]; other site 1117943012217 Q-loop/lid; other site 1117943012218 ABC transporter signature motif; other site 1117943012219 Walker B; other site 1117943012220 D-loop; other site 1117943012221 H-loop/switch region; other site 1117943012222 TOBE domain; Region: TOBE_2; pfam08402 1117943012223 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943012224 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943012225 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943012226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943012227 dimer interface [polypeptide binding]; other site 1117943012228 conserved gate region; other site 1117943012229 putative PBP binding loops; other site 1117943012230 ABC-ATPase subunit interface; other site 1117943012231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943012232 dimer interface [polypeptide binding]; other site 1117943012233 conserved gate region; other site 1117943012234 putative PBP binding loops; other site 1117943012235 ABC-ATPase subunit interface; other site 1117943012236 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943012237 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1117943012238 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1117943012239 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1117943012240 Predicted transcriptional regulator [Transcription]; Region: COG4189 1117943012241 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943012242 dimerization interface [polypeptide binding]; other site 1117943012243 putative DNA binding site [nucleotide binding]; other site 1117943012244 putative Zn2+ binding site [ion binding]; other site 1117943012245 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943012246 cyclase homology domain; Region: CHD; cd07302 1117943012247 nucleotidyl binding site; other site 1117943012248 metal binding site [ion binding]; metal-binding site 1117943012249 dimer interface [polypeptide binding]; other site 1117943012250 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943012251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943012252 TPR motif; other site 1117943012253 TPR repeat; Region: TPR_11; pfam13414 1117943012254 binding surface 1117943012255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943012256 binding surface 1117943012257 TPR motif; other site 1117943012258 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1117943012259 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1117943012260 NmrA-like family; Region: NmrA; pfam05368 1117943012261 NADP binding site [chemical binding]; other site 1117943012262 active site 1117943012263 regulatory binding site [polypeptide binding]; other site 1117943012264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943012265 LysR family transcriptional regulator; Provisional; Region: PRK14997 1117943012266 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1117943012267 putative effector binding pocket; other site 1117943012268 dimerization interface [polypeptide binding]; other site 1117943012269 Helix-turn-helix domain; Region: HTH_28; pfam13518 1117943012270 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943012271 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943012272 Integrase core domain; Region: rve; pfam00665 1117943012273 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1117943012274 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1117943012275 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1117943012276 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1117943012277 catalytic residues [active] 1117943012278 catalytic nucleophile [active] 1117943012279 Presynaptic Site I dimer interface [polypeptide binding]; other site 1117943012280 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1117943012281 Synaptic Flat tetramer interface [polypeptide binding]; other site 1117943012282 Synaptic Site I dimer interface [polypeptide binding]; other site 1117943012283 DNA binding site [nucleotide binding] 1117943012284 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1117943012285 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1117943012286 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1117943012287 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1117943012288 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1117943012289 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943012290 protein binding site [polypeptide binding]; other site 1117943012291 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943012292 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1117943012293 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1117943012294 ring oligomerisation interface [polypeptide binding]; other site 1117943012295 ATP/Mg binding site [chemical binding]; other site 1117943012296 stacking interactions; other site 1117943012297 hinge regions; other site 1117943012298 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1117943012299 oligomerisation interface [polypeptide binding]; other site 1117943012300 mobile loop; other site 1117943012301 roof hairpin; other site 1117943012302 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1117943012303 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1117943012304 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1117943012305 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1117943012306 putative dimer interface [polypeptide binding]; other site 1117943012307 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 1117943012308 SPW repeat; Region: SPW; pfam03779 1117943012309 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1117943012310 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1117943012311 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1117943012312 putative dimer interface [polypeptide binding]; other site 1117943012313 Usg-like family; Region: Usg; cl11567 1117943012314 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1117943012315 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1117943012316 SPW repeat; Region: SPW; pfam03779 1117943012317 SPW repeat; Region: SPW; pfam03779 1117943012318 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1117943012319 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1117943012320 RepB plasmid partitioning protein; Region: RepB; pfam07506 1117943012321 replication initiation protein RepC; Provisional; Region: PRK13824 1117943012322 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1117943012323 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 1117943012324 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1117943012325 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1117943012326 catalytic residues [active] 1117943012327 catalytic nucleophile [active] 1117943012328 Presynaptic Site I dimer interface [polypeptide binding]; other site 1117943012329 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1117943012330 Synaptic Flat tetramer interface [polypeptide binding]; other site 1117943012331 Synaptic Site I dimer interface [polypeptide binding]; other site 1117943012332 DNA binding site [nucleotide binding] 1117943012333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1117943012334 Integrase core domain; Region: rve; pfam00665 1117943012335 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1117943012336 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1117943012337 catalytic residues [active] 1117943012338 catalytic nucleophile [active] 1117943012339 Presynaptic Site I dimer interface [polypeptide binding]; other site 1117943012340 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1117943012341 Synaptic Flat tetramer interface [polypeptide binding]; other site 1117943012342 Synaptic Site I dimer interface [polypeptide binding]; other site 1117943012343 DNA binding site [nucleotide binding] 1117943012344 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1117943012345 DNA-binding interface [nucleotide binding]; DNA binding site 1117943012346 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943012347 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943012348 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943012349 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1117943012350 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1117943012351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943012352 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943012353 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943012354 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943012355 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943012356 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943012357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1117943012358 Transposase; Region: HTH_Tnp_1; pfam01527 1117943012359 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1117943012360 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943012361 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1117943012362 Integrase core domain; Region: rve; pfam00665 1117943012363 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1117943012364 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1117943012365 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1117943012366 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1117943012367 putative active site [active] 1117943012368 putative NTP binding site [chemical binding]; other site 1117943012369 putative nucleic acid binding site [nucleotide binding]; other site 1117943012370 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cl09835 1117943012371 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1117943012372 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1117943012373 putative active site [active] 1117943012374 putative NTP binding site [chemical binding]; other site 1117943012375 putative nucleic acid binding site [nucleotide binding]; other site 1117943012376 HTH-like domain; Region: HTH_21; pfam13276 1117943012377 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943012378 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943012379 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1117943012380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1117943012381 Integrase core domain; Region: rve; pfam00665 1117943012382 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1117943012383 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1117943012384 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1117943012385 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1117943012386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943012387 S-adenosylmethionine binding site [chemical binding]; other site 1117943012388 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1117943012389 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 1117943012390 Protein of unknown function (DUF1419); Region: DUF1419; pfam07215 1117943012391 Toprim-like; Region: Toprim_2; pfam13155 1117943012392 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943012393 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943012394 Winged helix-turn helix; Region: HTH_33; pfam13592 1117943012395 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943012396 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943012397 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 1117943012398 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1117943012399 Helix-turn-helix domain; Region: HTH_18; pfam12833 1117943012400 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943012401 DNA binding residues [nucleotide binding] 1117943012402 dimerization interface [polypeptide binding]; other site 1117943012403 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1117943012404 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1117943012405 Walker A/P-loop; other site 1117943012406 ATP binding site [chemical binding]; other site 1117943012407 Q-loop/lid; other site 1117943012408 ABC transporter signature motif; other site 1117943012409 Walker B; other site 1117943012410 D-loop; other site 1117943012411 H-loop/switch region; other site 1117943012412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943012413 dimer interface [polypeptide binding]; other site 1117943012414 conserved gate region; other site 1117943012415 putative PBP binding loops; other site 1117943012416 ABC-ATPase subunit interface; other site 1117943012417 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1117943012418 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943012419 substrate binding pocket [chemical binding]; other site 1117943012420 membrane-bound complex binding site; other site 1117943012421 hinge residues; other site 1117943012422 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 1117943012423 pyridoxal phosphate enzyme, MJ0158 family; Region: pyridox_MJ0158; TIGR03576 1117943012424 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 1117943012425 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1117943012426 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1117943012427 NAD(P) binding site [chemical binding]; other site 1117943012428 catalytic residues [active] 1117943012429 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1117943012430 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1117943012431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943012432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943012433 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1117943012434 putative dimerization interface [polypeptide binding]; other site 1117943012435 FCD domain; Region: FCD; pfam07729 1117943012436 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943012437 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1117943012438 Integrase core domain; Region: rve; pfam00665 1117943012439 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1117943012440 Leucine rich repeat; Region: LRR_8; pfam13855 1117943012441 Leucine-rich repeats; other site 1117943012442 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1117943012443 Leucine rich repeat; Region: LRR_8; pfam13855 1117943012444 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943012445 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1117943012446 Integrase core domain; Region: rve; pfam00665 1117943012447 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1117943012448 ParB-like nuclease domain; Region: ParB; smart00470 1117943012449 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1117943012450 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 1117943012451 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1117943012452 Staphylococcal nuclease homologues; Region: SNc; smart00318 1117943012453 Catalytic site; other site 1117943012454 Protein of unknown function (DUF736); Region: DUF736; pfam05284 1117943012455 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1117943012456 FIC domain binding interface [polypeptide binding]; other site 1117943012457 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1117943012458 Fic/DOC family; Region: Fic; cl00960 1117943012459 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1117943012460 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1117943012461 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 1117943012462 ParB-like nuclease domain; Region: ParB; smart00470 1117943012463 replication initiation protein RepC; Provisional; Region: PRK13824 1117943012464 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1117943012465 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 1117943012466 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1117943012467 active site 1117943012468 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 1117943012469 HTH DNA binding domain; Region: HTH_13; pfam11972 1117943012470 Integrase core domain; Region: rve; pfam00665 1117943012471 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1117943012472 EamA-like transporter family; Region: EamA; pfam00892 1117943012473 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1117943012474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943012475 DNA-binding site [nucleotide binding]; DNA binding site 1117943012476 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943012477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943012478 homodimer interface [polypeptide binding]; other site 1117943012479 catalytic residue [active] 1117943012480 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1117943012481 Chromate transporter; Region: Chromate_transp; pfam02417 1117943012482 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1117943012483 active site residue [active] 1117943012484 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 1117943012485 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1117943012486 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1117943012487 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1117943012488 substrate binding site [chemical binding]; other site 1117943012489 catalytic Zn binding site [ion binding]; other site 1117943012490 NAD binding site [chemical binding]; other site 1117943012491 structural Zn binding site [ion binding]; other site 1117943012492 dimer interface [polypeptide binding]; other site 1117943012493 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1117943012494 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1117943012495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1117943012496 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1117943012497 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1117943012498 putative ligand binding site [chemical binding]; other site 1117943012499 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1117943012500 [2Fe-2S] cluster binding site [ion binding]; other site 1117943012501 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1117943012502 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1117943012503 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943012504 DNA binding site [nucleotide binding] 1117943012505 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1117943012506 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1117943012507 putative ligand binding site [chemical binding]; other site 1117943012508 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1117943012509 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943012510 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1117943012511 dimerization interface [polypeptide binding]; other site 1117943012512 substrate binding pocket [chemical binding]; other site 1117943012513 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 1117943012514 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1117943012515 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1117943012516 phosphate binding site [ion binding]; other site 1117943012517 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1117943012518 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1117943012519 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1117943012520 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1117943012521 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1117943012522 conserved cys residue [active] 1117943012523 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943012524 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943012525 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1117943012526 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1117943012527 FAD binding pocket [chemical binding]; other site 1117943012528 FAD binding motif [chemical binding]; other site 1117943012529 phosphate binding motif [ion binding]; other site 1117943012530 beta-alpha-beta structure motif; other site 1117943012531 NAD binding pocket [chemical binding]; other site 1117943012532 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1117943012533 catalytic loop [active] 1117943012534 iron binding site [ion binding]; other site 1117943012535 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1117943012536 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1117943012537 [2Fe-2S] cluster binding site [ion binding]; other site 1117943012538 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1117943012539 putative alpha subunit interface [polypeptide binding]; other site 1117943012540 putative active site [active] 1117943012541 putative substrate binding site [chemical binding]; other site 1117943012542 Fe binding site [ion binding]; other site 1117943012543 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1117943012544 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943012545 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943012546 dimerization interface [polypeptide binding]; other site 1117943012547 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1117943012548 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943012549 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1117943012550 Walker A/P-loop; other site 1117943012551 ATP binding site [chemical binding]; other site 1117943012552 Q-loop/lid; other site 1117943012553 ABC transporter signature motif; other site 1117943012554 Walker B; other site 1117943012555 D-loop; other site 1117943012556 H-loop/switch region; other site 1117943012557 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1117943012558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943012559 dimer interface [polypeptide binding]; other site 1117943012560 conserved gate region; other site 1117943012561 putative PBP binding loops; other site 1117943012562 ABC-ATPase subunit interface; other site 1117943012563 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1117943012564 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1117943012565 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1117943012566 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1117943012567 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1117943012568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943012569 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1117943012570 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1117943012571 putative active site [active] 1117943012572 putative FMN binding site [chemical binding]; other site 1117943012573 putative substrate binding site [chemical binding]; other site 1117943012574 putative catalytic residue [active] 1117943012575 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1117943012576 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1117943012577 Ligand binding site [chemical binding]; other site 1117943012578 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1117943012579 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1117943012580 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1117943012581 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1117943012582 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1117943012583 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1117943012584 substrate binding site [chemical binding]; other site 1117943012585 catalytic Zn binding site [ion binding]; other site 1117943012586 NAD binding site [chemical binding]; other site 1117943012587 structural Zn binding site [ion binding]; other site 1117943012588 dimer interface [polypeptide binding]; other site 1117943012589 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 1117943012590 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1117943012591 putative NAD(P) binding site [chemical binding]; other site 1117943012592 hypothetical protein; Provisional; Region: PRK07482 1117943012593 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1117943012594 inhibitor-cofactor binding pocket; inhibition site 1117943012595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943012596 catalytic residue [active] 1117943012597 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1117943012598 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1117943012599 NAD(P) binding site [chemical binding]; other site 1117943012600 catalytic residues [active] 1117943012601 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943012602 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943012603 putative DNA binding site [nucleotide binding]; other site 1117943012604 putative Zn2+ binding site [ion binding]; other site 1117943012605 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943012606 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1117943012607 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943012608 DNA-binding site [nucleotide binding]; DNA binding site 1117943012609 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943012610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943012611 homodimer interface [polypeptide binding]; other site 1117943012612 catalytic residue [active] 1117943012613 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 1117943012614 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1117943012615 Walker A/P-loop; other site 1117943012616 ATP binding site [chemical binding]; other site 1117943012617 Q-loop/lid; other site 1117943012618 ABC transporter signature motif; other site 1117943012619 Walker B; other site 1117943012620 D-loop; other site 1117943012621 H-loop/switch region; other site 1117943012622 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 1117943012623 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943012624 substrate binding pocket [chemical binding]; other site 1117943012625 membrane-bound complex binding site; other site 1117943012626 hinge residues; other site 1117943012627 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1117943012628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943012629 dimer interface [polypeptide binding]; other site 1117943012630 conserved gate region; other site 1117943012631 putative PBP binding loops; other site 1117943012632 ABC-ATPase subunit interface; other site 1117943012633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943012634 dimer interface [polypeptide binding]; other site 1117943012635 conserved gate region; other site 1117943012636 putative PBP binding loops; other site 1117943012637 ABC-ATPase subunit interface; other site 1117943012638 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1117943012639 ectoine utilization protein EutC; Validated; Region: PRK08291 1117943012640 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1117943012641 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 1117943012642 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1117943012643 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1117943012644 active site 1117943012645 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 1117943012646 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 1117943012647 putative active site [active] 1117943012648 Zn binding site [ion binding]; other site 1117943012649 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1117943012650 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1117943012651 metal binding site [ion binding]; metal-binding site 1117943012652 substrate binding pocket [chemical binding]; other site 1117943012653 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 1117943012654 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1117943012655 putative NAD(P) binding site [chemical binding]; other site 1117943012656 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1117943012657 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943012658 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1117943012659 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1117943012660 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1117943012661 inhibitor site; inhibition site 1117943012662 active site 1117943012663 dimer interface [polypeptide binding]; other site 1117943012664 catalytic residue [active] 1117943012665 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943012666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943012667 DNA-binding site [nucleotide binding]; DNA binding site 1117943012668 FCD domain; Region: FCD; pfam07729 1117943012669 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 1117943012670 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1117943012671 Walker A/P-loop; other site 1117943012672 ATP binding site [chemical binding]; other site 1117943012673 Q-loop/lid; other site 1117943012674 ABC transporter signature motif; other site 1117943012675 Walker B; other site 1117943012676 D-loop; other site 1117943012677 H-loop/switch region; other site 1117943012678 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1117943012679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943012680 dimer interface [polypeptide binding]; other site 1117943012681 conserved gate region; other site 1117943012682 putative PBP binding loops; other site 1117943012683 ABC-ATPase subunit interface; other site 1117943012684 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1117943012685 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1117943012686 metal binding site [ion binding]; metal-binding site 1117943012687 substrate binding pocket [chemical binding]; other site 1117943012688 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1117943012689 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943012690 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1117943012691 dimerization interface [polypeptide binding]; other site 1117943012692 substrate binding pocket [chemical binding]; other site 1117943012693 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 1117943012694 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1117943012695 conserved cys residue [active] 1117943012696 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1117943012697 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943012698 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1117943012699 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1117943012700 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1117943012701 classical (c) SDRs; Region: SDR_c; cd05233 1117943012702 NAD(P) binding site [chemical binding]; other site 1117943012703 active site 1117943012704 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1117943012705 classical (c) SDRs; Region: SDR_c; cd05233 1117943012706 NAD(P) binding site [chemical binding]; other site 1117943012707 active site 1117943012708 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1117943012709 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1117943012710 peptidase T; Region: peptidase-T; TIGR01882 1117943012711 metal binding site [ion binding]; metal-binding site 1117943012712 dimer interface [polypeptide binding]; other site 1117943012713 Dodecin; Region: Dodecin; pfam07311 1117943012714 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1117943012715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943012716 putative substrate translocation pore; other site 1117943012717 Predicted flavoproteins [General function prediction only]; Region: COG2081 1117943012718 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1117943012719 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1117943012720 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943012721 DNA binding site [nucleotide binding] 1117943012722 domain linker motif; other site 1117943012723 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1117943012724 ligand binding site [chemical binding]; other site 1117943012725 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943012726 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1117943012727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943012728 dimer interface [polypeptide binding]; other site 1117943012729 conserved gate region; other site 1117943012730 putative PBP binding loops; other site 1117943012731 ABC-ATPase subunit interface; other site 1117943012732 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943012733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943012734 dimer interface [polypeptide binding]; other site 1117943012735 conserved gate region; other site 1117943012736 putative PBP binding loops; other site 1117943012737 ABC-ATPase subunit interface; other site 1117943012738 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1117943012739 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943012740 Walker A/P-loop; other site 1117943012741 ATP binding site [chemical binding]; other site 1117943012742 Q-loop/lid; other site 1117943012743 ABC transporter signature motif; other site 1117943012744 Walker B; other site 1117943012745 D-loop; other site 1117943012746 H-loop/switch region; other site 1117943012747 TOBE domain; Region: TOBE_2; pfam08402 1117943012748 Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813 1117943012749 conserved cys residue [active] 1117943012750 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943012751 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943012752 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1117943012753 SPW repeat; Region: SPW; pfam03779 1117943012754 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1117943012755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943012756 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1117943012757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943012758 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1117943012759 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 1117943012760 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1117943012761 L-asparagine permease; Provisional; Region: PRK15049 1117943012762 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1117943012763 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1117943012764 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1117943012765 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1117943012766 type III secretion system protein YscR; Provisional; Region: PRK12797 1117943012767 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1117943012768 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1117943012769 FHIPEP family; Region: FHIPEP; pfam00771 1117943012770 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1117943012771 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1117943012772 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1117943012773 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 1117943012774 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 1117943012775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1117943012776 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1117943012777 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1117943012778 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1117943012779 Na binding site [ion binding]; other site 1117943012780 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1117943012781 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1117943012782 Na binding site [ion binding]; other site 1117943012783 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1117943012784 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943012785 putative active site [active] 1117943012786 heme pocket [chemical binding]; other site 1117943012787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943012788 dimer interface [polypeptide binding]; other site 1117943012789 phosphorylation site [posttranslational modification] 1117943012790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943012791 ATP binding site [chemical binding]; other site 1117943012792 Mg2+ binding site [ion binding]; other site 1117943012793 G-X-G motif; other site 1117943012794 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1117943012795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943012796 active site 1117943012797 phosphorylation site [posttranslational modification] 1117943012798 intermolecular recognition site; other site 1117943012799 dimerization interface [polypeptide binding]; other site 1117943012800 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1117943012801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943012802 active site 1117943012803 phosphorylation site [posttranslational modification] 1117943012804 intermolecular recognition site; other site 1117943012805 dimerization interface [polypeptide binding]; other site 1117943012806 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943012807 dimerization interface [polypeptide binding]; other site 1117943012808 DNA binding residues [nucleotide binding] 1117943012809 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943012810 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943012811 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943012812 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943012813 metal binding site [ion binding]; metal-binding site 1117943012814 active site 1117943012815 I-site; other site 1117943012816 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1117943012817 camphor resistance protein CrcB; Provisional; Region: PRK14198 1117943012818 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1117943012819 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943012820 dimerization interface [polypeptide binding]; other site 1117943012821 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1117943012822 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1117943012823 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1117943012824 dimer interface [polypeptide binding]; other site 1117943012825 putative CheW interface [polypeptide binding]; other site 1117943012826 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1117943012827 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943012828 DNA binding site [nucleotide binding] 1117943012829 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1117943012830 domain linker motif; other site 1117943012831 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 1117943012832 putative ligand binding site [chemical binding]; other site 1117943012833 putative dimerization interface [polypeptide binding]; other site 1117943012834 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1117943012835 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1117943012836 DctM-like transporters; Region: DctM; pfam06808 1117943012837 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1117943012838 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1117943012839 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1117943012840 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1117943012841 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1117943012842 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1117943012843 substrate binding pocket [chemical binding]; other site 1117943012844 membrane-bound complex binding site; other site 1117943012845 hinge residues; other site 1117943012846 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943012847 dimerization interface [polypeptide binding]; other site 1117943012848 PAS domain; Region: PAS_9; pfam13426 1117943012849 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943012850 putative active site [active] 1117943012851 heme pocket [chemical binding]; other site 1117943012852 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943012853 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943012854 metal binding site [ion binding]; metal-binding site 1117943012855 active site 1117943012856 I-site; other site 1117943012857 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1117943012858 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1117943012859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943012860 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1117943012861 dimerization interface [polypeptide binding]; other site 1117943012862 substrate binding pocket [chemical binding]; other site 1117943012863 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1117943012864 putative NAD(P) binding site [chemical binding]; other site 1117943012865 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 1117943012866 putative active site [active] 1117943012867 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1117943012868 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1117943012869 Walker A/P-loop; other site 1117943012870 ATP binding site [chemical binding]; other site 1117943012871 Q-loop/lid; other site 1117943012872 ABC transporter signature motif; other site 1117943012873 Walker B; other site 1117943012874 D-loop; other site 1117943012875 H-loop/switch region; other site 1117943012876 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1117943012877 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943012878 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943012879 TM-ABC transporter signature motif; other site 1117943012880 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315 1117943012881 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1117943012882 putative ligand binding site [chemical binding]; other site 1117943012883 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1117943012884 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943012885 DNA binding site [nucleotide binding] 1117943012886 domain linker motif; other site 1117943012887 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1117943012888 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943012889 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1117943012890 substrate binding pocket [chemical binding]; other site 1117943012891 membrane-bound complex binding site; other site 1117943012892 hinge residues; other site 1117943012893 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1117943012894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943012895 dimer interface [polypeptide binding]; other site 1117943012896 conserved gate region; other site 1117943012897 ABC-ATPase subunit interface; other site 1117943012898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943012899 dimer interface [polypeptide binding]; other site 1117943012900 conserved gate region; other site 1117943012901 ABC-ATPase subunit interface; other site 1117943012902 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1117943012903 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1117943012904 Walker A/P-loop; other site 1117943012905 ATP binding site [chemical binding]; other site 1117943012906 Q-loop/lid; other site 1117943012907 ABC transporter signature motif; other site 1117943012908 Walker B; other site 1117943012909 D-loop; other site 1117943012910 H-loop/switch region; other site 1117943012911 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 1117943012912 PemK-like protein; Region: PemK; pfam02452 1117943012913 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1117943012914 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943012915 DNA binding site [nucleotide binding] 1117943012916 domain linker motif; other site 1117943012917 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1117943012918 putative dimerization interface [polypeptide binding]; other site 1117943012919 putative ligand binding site [chemical binding]; other site 1117943012920 Predicted transcriptional regulators [Transcription]; Region: COG1733 1117943012921 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1117943012922 short chain dehydrogenase; Provisional; Region: PRK06179 1117943012923 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1117943012924 NADP binding site [chemical binding]; other site 1117943012925 active site 1117943012926 steroid binding site; other site 1117943012927 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1117943012928 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1117943012929 putative NAD(P) binding site [chemical binding]; other site 1117943012930 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1117943012931 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1117943012932 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1117943012933 ATP-binding site [chemical binding]; other site 1117943012934 Gluconate-6-phosphate binding site [chemical binding]; other site 1117943012935 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 1117943012936 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1117943012937 NADP binding site [chemical binding]; other site 1117943012938 homodimer interface [polypeptide binding]; other site 1117943012939 active site 1117943012940 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1117943012941 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1117943012942 putative ligand binding site [chemical binding]; other site 1117943012943 NAD binding site [chemical binding]; other site 1117943012944 catalytic site [active] 1117943012945 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1117943012946 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1117943012947 putative NAD(P) binding site [chemical binding]; other site 1117943012948 catalytic Zn binding site [ion binding]; other site 1117943012949 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1117943012950 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 1117943012951 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 1117943012952 active site 1117943012953 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1117943012954 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943012955 cyclase homology domain; Region: CHD; cd07302 1117943012956 nucleotidyl binding site; other site 1117943012957 metal binding site [ion binding]; metal-binding site 1117943012958 dimer interface [polypeptide binding]; other site 1117943012959 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943012960 TPR repeat; Region: TPR_11; pfam13414 1117943012961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943012962 TPR motif; other site 1117943012963 binding surface 1117943012964 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1117943012965 active site residue [active] 1117943012966 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1117943012967 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943012968 NAD(P) binding site [chemical binding]; other site 1117943012969 active site 1117943012970 hypothetical protein; Region: PHA00726 1117943012971 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 1117943012972 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1117943012973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943012974 DNA-binding site [nucleotide binding]; DNA binding site 1117943012975 FCD domain; Region: FCD; pfam07729 1117943012976 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1117943012977 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1117943012978 active site 1117943012979 inhibitor site; inhibition site 1117943012980 dimer interface [polypeptide binding]; other site 1117943012981 catalytic residue [active] 1117943012982 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1117943012983 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1117943012984 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1117943012985 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1117943012986 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1117943012987 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1117943012988 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1117943012989 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1117943012990 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1117943012991 catalytic loop [active] 1117943012992 iron binding site [ion binding]; other site 1117943012993 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1117943012994 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1117943012995 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1117943012996 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1117943012997 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1117943012998 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1117943012999 ligand binding site [chemical binding]; other site 1117943013000 dimerization interface [polypeptide binding]; other site 1117943013001 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5618 1117943013002 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1117943013003 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1117943013004 Walker A/P-loop; other site 1117943013005 ATP binding site [chemical binding]; other site 1117943013006 Q-loop/lid; other site 1117943013007 ABC transporter signature motif; other site 1117943013008 Walker B; other site 1117943013009 D-loop; other site 1117943013010 H-loop/switch region; other site 1117943013011 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1117943013012 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943013013 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943013014 TM-ABC transporter signature motif; other site 1117943013015 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943013016 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943013017 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1117943013018 transcriptional regulator NanR; Provisional; Region: PRK03837 1117943013019 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943013020 DNA-binding site [nucleotide binding]; DNA binding site 1117943013021 FCD domain; Region: FCD; pfam07729 1117943013022 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 1117943013023 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 1117943013024 dimer interface [polypeptide binding]; other site 1117943013025 active site 1117943013026 catalytic residue [active] 1117943013027 metal binding site [ion binding]; metal-binding site 1117943013028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1117943013029 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1117943013030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943013031 active site 1117943013032 phosphorylation site [posttranslational modification] 1117943013033 intermolecular recognition site; other site 1117943013034 dimerization interface [polypeptide binding]; other site 1117943013035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943013036 Walker A motif; other site 1117943013037 ATP binding site [chemical binding]; other site 1117943013038 Walker B motif; other site 1117943013039 arginine finger; other site 1117943013040 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1117943013041 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1117943013042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943013043 dimer interface [polypeptide binding]; other site 1117943013044 phosphorylation site [posttranslational modification] 1117943013045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943013046 ATP binding site [chemical binding]; other site 1117943013047 Mg2+ binding site [ion binding]; other site 1117943013048 G-X-G motif; other site 1117943013049 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1117943013050 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1117943013051 Response regulator receiver domain; Region: Response_reg; pfam00072 1117943013052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943013053 active site 1117943013054 phosphorylation site [posttranslational modification] 1117943013055 intermolecular recognition site; other site 1117943013056 dimerization interface [polypeptide binding]; other site 1117943013057 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1117943013058 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943013059 DNA binding residues [nucleotide binding] 1117943013060 dimerization interface [polypeptide binding]; other site 1117943013061 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1117943013062 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943013063 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943013064 dimer interface [polypeptide binding]; other site 1117943013065 phosphorylation site [posttranslational modification] 1117943013066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943013067 ATP binding site [chemical binding]; other site 1117943013068 Mg2+ binding site [ion binding]; other site 1117943013069 G-X-G motif; other site 1117943013070 Response regulator receiver domain; Region: Response_reg; pfam00072 1117943013071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943013072 active site 1117943013073 phosphorylation site [posttranslational modification] 1117943013074 intermolecular recognition site; other site 1117943013075 dimerization interface [polypeptide binding]; other site 1117943013076 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943013077 putative DNA binding site [nucleotide binding]; other site 1117943013078 putative Zn2+ binding site [ion binding]; other site 1117943013079 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1117943013080 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1117943013081 active site 1117943013082 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1117943013083 amphipathic channel; other site 1117943013084 Asn-Pro-Ala signature motifs; other site 1117943013085 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1117943013086 ArsC family; Region: ArsC; pfam03960 1117943013087 catalytic residues [active] 1117943013088 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1117943013089 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1117943013090 putative ligand binding site [chemical binding]; other site 1117943013091 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1117943013092 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943013093 TM-ABC transporter signature motif; other site 1117943013094 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1117943013095 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1117943013096 TM-ABC transporter signature motif; other site 1117943013097 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1117943013098 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1117943013099 Walker A/P-loop; other site 1117943013100 ATP binding site [chemical binding]; other site 1117943013101 Q-loop/lid; other site 1117943013102 ABC transporter signature motif; other site 1117943013103 Walker B; other site 1117943013104 D-loop; other site 1117943013105 H-loop/switch region; other site 1117943013106 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1117943013107 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1117943013108 Walker A/P-loop; other site 1117943013109 ATP binding site [chemical binding]; other site 1117943013110 Q-loop/lid; other site 1117943013111 ABC transporter signature motif; other site 1117943013112 Walker B; other site 1117943013113 D-loop; other site 1117943013114 H-loop/switch region; other site 1117943013115 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 1117943013116 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1117943013117 putative ligand binding site [chemical binding]; other site 1117943013118 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1117943013119 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1117943013120 Walker A/P-loop; other site 1117943013121 ATP binding site [chemical binding]; other site 1117943013122 Q-loop/lid; other site 1117943013123 ABC transporter signature motif; other site 1117943013124 Walker B; other site 1117943013125 D-loop; other site 1117943013126 H-loop/switch region; other site 1117943013127 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1117943013128 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943013129 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943013130 TM-ABC transporter signature motif; other site 1117943013131 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1117943013132 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 1117943013133 putative active site pocket [active] 1117943013134 metal binding site [ion binding]; metal-binding site 1117943013135 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 1117943013136 MerR family regulatory protein; Region: MerR; pfam00376 1117943013137 DNA binding residues [nucleotide binding] 1117943013138 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1117943013139 P-loop; other site 1117943013140 Magnesium ion binding site [ion binding]; other site 1117943013141 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1117943013142 Magnesium ion binding site [ion binding]; other site 1117943013143 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 1117943013144 ParB-like nuclease domain; Region: ParB; smart00470 1117943013145 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943013146 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943013147 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1117943013148 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1117943013149 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1117943013150 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943013151 DNA binding site [nucleotide binding] 1117943013152 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1117943013153 putative ligand binding site [chemical binding]; other site 1117943013154 Predicted membrane protein [Function unknown]; Region: COG2259 1117943013155 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1117943013156 MarR family; Region: MarR_2; pfam12802 1117943013157 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1117943013158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943013159 Coenzyme A binding pocket [chemical binding]; other site 1117943013160 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1117943013161 Ferritin-like domain; Region: Ferritin_2; pfam13668 1117943013162 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1117943013163 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1117943013164 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1117943013165 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943013166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943013167 DNA-binding site [nucleotide binding]; DNA binding site 1117943013168 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1117943013169 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1117943013170 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943013171 substrate binding pocket [chemical binding]; other site 1117943013172 membrane-bound complex binding site; other site 1117943013173 hinge residues; other site 1117943013174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943013175 dimer interface [polypeptide binding]; other site 1117943013176 conserved gate region; other site 1117943013177 putative PBP binding loops; other site 1117943013178 ABC-ATPase subunit interface; other site 1117943013179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1117943013180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943013181 ABC-ATPase subunit interface; other site 1117943013182 putative PBP binding loops; other site 1117943013183 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1117943013184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943013185 Walker A/P-loop; other site 1117943013186 ATP binding site [chemical binding]; other site 1117943013187 Q-loop/lid; other site 1117943013188 ABC transporter signature motif; other site 1117943013189 Walker B; other site 1117943013190 D-loop; other site 1117943013191 H-loop/switch region; other site 1117943013192 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1117943013193 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1117943013194 Predicted outer membrane protein [Function unknown]; Region: COG3652 1117943013195 RNA polymerase sigma factor; Provisional; Region: PRK11922 1117943013196 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1117943013197 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1117943013198 DNA binding residues [nucleotide binding] 1117943013199 acylphosphatase; Provisional; Region: PRK14425 1117943013200 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1117943013201 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1117943013202 dimer interface [polypeptide binding]; other site 1117943013203 active site 1117943013204 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1117943013205 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1117943013206 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1117943013207 Bacterial transcriptional regulator; Region: IclR; pfam01614 1117943013208 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943013209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943013210 DNA-binding site [nucleotide binding]; DNA binding site 1117943013211 FCD domain; Region: FCD; pfam07729 1117943013212 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1117943013213 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1117943013214 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1117943013215 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1117943013216 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943013217 cyclase homology domain; Region: CHD; cd07302 1117943013218 nucleotidyl binding site; other site 1117943013219 metal binding site [ion binding]; metal-binding site 1117943013220 dimer interface [polypeptide binding]; other site 1117943013221 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943013222 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943013223 TPR motif; other site 1117943013224 binding surface 1117943013225 TPR repeat; Region: TPR_11; pfam13414 1117943013226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943013227 TPR motif; other site 1117943013228 binding surface 1117943013229 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943013230 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943013231 DNA-binding site [nucleotide binding]; DNA binding site 1117943013232 FCD domain; Region: FCD; pfam07729 1117943013233 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1117943013234 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1117943013235 inhibitor site; inhibition site 1117943013236 active site 1117943013237 dimer interface [polypeptide binding]; other site 1117943013238 catalytic residue [active] 1117943013239 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1117943013240 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1117943013241 NAD(P) binding site [chemical binding]; other site 1117943013242 catalytic residues [active] 1117943013243 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1117943013244 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943013245 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1117943013246 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1117943013247 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 1117943013248 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1117943013249 Walker A/P-loop; other site 1117943013250 ATP binding site [chemical binding]; other site 1117943013251 Q-loop/lid; other site 1117943013252 ABC transporter signature motif; other site 1117943013253 Walker B; other site 1117943013254 D-loop; other site 1117943013255 H-loop/switch region; other site 1117943013256 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1117943013257 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1117943013258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943013259 dimer interface [polypeptide binding]; other site 1117943013260 conserved gate region; other site 1117943013261 putative PBP binding loops; other site 1117943013262 ABC-ATPase subunit interface; other site 1117943013263 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1117943013264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943013265 dimer interface [polypeptide binding]; other site 1117943013266 conserved gate region; other site 1117943013267 ABC-ATPase subunit interface; other site 1117943013268 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 1117943013269 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1117943013270 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1117943013271 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1117943013272 conserved cys residue [active] 1117943013273 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943013274 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1117943013275 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943013276 DNA binding site [nucleotide binding] 1117943013277 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943013278 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943013279 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1117943013280 NAD(P) binding site [chemical binding]; other site 1117943013281 active site 1117943013282 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1117943013283 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1117943013284 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943013285 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1117943013286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943013287 putative substrate translocation pore; other site 1117943013288 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1117943013289 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1117943013290 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1117943013291 colanic acid exporter; Provisional; Region: PRK10459 1117943013292 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1117943013293 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1117943013294 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1117943013295 putative ADP-binding pocket [chemical binding]; other site 1117943013296 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1117943013297 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1117943013298 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1117943013299 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1117943013300 Moco binding site; other site 1117943013301 metal coordination site [ion binding]; other site 1117943013302 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1117943013303 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1117943013304 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1117943013305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943013306 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943013307 dimerization interface [polypeptide binding]; other site 1117943013308 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1117943013309 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1117943013310 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1117943013311 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 1117943013312 heterodimer interface [polypeptide binding]; other site 1117943013313 multimer interface [polypeptide binding]; other site 1117943013314 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1117943013315 active site 1117943013316 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1117943013317 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1117943013318 heterodimer interface [polypeptide binding]; other site 1117943013319 active site 1117943013320 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975 1117943013321 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1117943013322 tetramer interface [polypeptide binding]; other site 1117943013323 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1117943013324 CHASE2 domain; Region: CHASE2; pfam05226 1117943013325 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1117943013326 cyclase homology domain; Region: CHD; cd07302 1117943013327 nucleotidyl binding site; other site 1117943013328 metal binding site [ion binding]; metal-binding site 1117943013329 dimer interface [polypeptide binding]; other site 1117943013330 FecR protein; Region: FecR; pfam04773 1117943013331 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943013332 binding surface 1117943013333 TPR motif; other site 1117943013334 TPR repeat; Region: TPR_11; pfam13414 1117943013335 TPR repeat; Region: TPR_11; pfam13414 1117943013336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1117943013337 binding surface 1117943013338 TPR motif; other site 1117943013339 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1117943013340 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1117943013341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943013342 DNA-binding site [nucleotide binding]; DNA binding site 1117943013343 FCD domain; Region: FCD; pfam07729 1117943013344 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1117943013345 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1117943013346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1117943013347 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1117943013348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1117943013349 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1117943013350 dihydroxyacetone kinase; Provisional; Region: PRK14479 1117943013351 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1117943013352 DAK2 domain; Region: Dak2; pfam02734 1117943013353 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 1117943013354 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1117943013355 trimer interface [polypeptide binding]; other site 1117943013356 active site 1117943013357 substrate binding site [chemical binding]; other site 1117943013358 CoA binding site [chemical binding]; other site 1117943013359 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1117943013360 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943013361 Walker A/P-loop; other site 1117943013362 ATP binding site [chemical binding]; other site 1117943013363 Q-loop/lid; other site 1117943013364 ABC transporter signature motif; other site 1117943013365 Walker B; other site 1117943013366 D-loop; other site 1117943013367 H-loop/switch region; other site 1117943013368 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1117943013369 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943013370 Walker A/P-loop; other site 1117943013371 ATP binding site [chemical binding]; other site 1117943013372 Q-loop/lid; other site 1117943013373 ABC transporter signature motif; other site 1117943013374 Walker B; other site 1117943013375 D-loop; other site 1117943013376 H-loop/switch region; other site 1117943013377 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1117943013378 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 1117943013379 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; cl01456 1117943013380 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 1117943013381 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1117943013382 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 1117943013383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943013384 DNA-binding site [nucleotide binding]; DNA binding site 1117943013385 UTRA domain; Region: UTRA; pfam07702 1117943013386 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1117943013387 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1117943013388 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 1117943013389 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1117943013390 C-terminal domain interface [polypeptide binding]; other site 1117943013391 GSH binding site (G-site) [chemical binding]; other site 1117943013392 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1117943013393 dimer interface [polypeptide binding]; other site 1117943013394 Glutathione S-transferase, C-terminal domain; Region: GST_C_2; pfam13410 1117943013395 N-terminal domain interface [polypeptide binding]; other site 1117943013396 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1117943013397 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943013398 Zn binding site [ion binding]; other site 1117943013399 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1117943013400 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1117943013401 acyl-activating enzyme (AAE) consensus motif; other site 1117943013402 AMP binding site [chemical binding]; other site 1117943013403 active site 1117943013404 CoA binding site [chemical binding]; other site 1117943013405 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 1117943013406 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1117943013407 active site 1117943013408 oxalacetate binding site [chemical binding]; other site 1117943013409 citrylCoA binding site [chemical binding]; other site 1117943013410 coenzyme A binding site [chemical binding]; other site 1117943013411 catalytic triad [active] 1117943013412 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1117943013413 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1117943013414 active site 1117943013415 substrate binding site [chemical binding]; other site 1117943013416 coenzyme B12 binding site [chemical binding]; other site 1117943013417 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1117943013418 B12 binding site [chemical binding]; other site 1117943013419 cobalt ligand [ion binding]; other site 1117943013420 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1117943013421 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1117943013422 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1117943013423 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1117943013424 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1117943013425 carboxyltransferase (CT) interaction site; other site 1117943013426 biotinylation site [posttranslational modification]; other site 1117943013427 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1117943013428 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1117943013429 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1117943013430 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943013431 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943013432 non-specific DNA binding site [nucleotide binding]; other site 1117943013433 salt bridge; other site 1117943013434 sequence-specific DNA binding site [nucleotide binding]; other site 1117943013435 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1117943013436 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1117943013437 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1117943013438 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1117943013439 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 1117943013440 substrate binding pocket [chemical binding]; other site 1117943013441 FAD binding site [chemical binding]; other site 1117943013442 catalytic base [active] 1117943013443 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1117943013444 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1117943013445 substrate binding site [chemical binding]; other site 1117943013446 oxyanion hole (OAH) forming residues; other site 1117943013447 trimer interface [polypeptide binding]; other site 1117943013448 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1117943013449 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1117943013450 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1117943013451 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 1117943013452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943013453 NAD(P) binding site [chemical binding]; other site 1117943013454 active site 1117943013455 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 1117943013456 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1117943013457 active site 1117943013458 zinc binding site [ion binding]; other site 1117943013459 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1117943013460 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1117943013461 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943013462 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943013463 TM-ABC transporter signature motif; other site 1117943013464 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943013465 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943013466 TM-ABC transporter signature motif; other site 1117943013467 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1117943013468 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1117943013469 Walker A/P-loop; other site 1117943013470 ATP binding site [chemical binding]; other site 1117943013471 Q-loop/lid; other site 1117943013472 ABC transporter signature motif; other site 1117943013473 Walker B; other site 1117943013474 D-loop; other site 1117943013475 H-loop/switch region; other site 1117943013476 sulfite oxidase; Provisional; Region: PLN00177 1117943013477 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 1117943013478 Moco binding site; other site 1117943013479 metal coordination site [ion binding]; other site 1117943013480 dimerization interface [polypeptide binding]; other site 1117943013481 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1117943013482 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1117943013483 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1117943013484 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943013485 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943013486 DNA-binding site [nucleotide binding]; DNA binding site 1117943013487 FCD domain; Region: FCD; pfam07729 1117943013488 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1117943013489 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1117943013490 active site 1117943013491 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943013492 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943013493 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1117943013494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943013495 dimer interface [polypeptide binding]; other site 1117943013496 conserved gate region; other site 1117943013497 putative PBP binding loops; other site 1117943013498 ABC-ATPase subunit interface; other site 1117943013499 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943013500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943013501 dimer interface [polypeptide binding]; other site 1117943013502 conserved gate region; other site 1117943013503 putative PBP binding loops; other site 1117943013504 ABC-ATPase subunit interface; other site 1117943013505 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1117943013506 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943013507 Walker A/P-loop; other site 1117943013508 ATP binding site [chemical binding]; other site 1117943013509 Q-loop/lid; other site 1117943013510 ABC transporter signature motif; other site 1117943013511 Walker B; other site 1117943013512 D-loop; other site 1117943013513 H-loop/switch region; other site 1117943013514 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1117943013515 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1117943013516 Protein of unknown function (DUF2735); Region: DUF2735; pfam10931 1117943013517 glutamine synthetase; Region: PLN02284 1117943013518 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1117943013519 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1117943013520 HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3 1117943013521 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1117943013522 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1117943013523 FecR protein; Region: FecR; pfam04773 1117943013524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943013525 TPR motif; other site 1117943013526 binding surface 1117943013527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943013528 binding surface 1117943013529 TPR motif; other site 1117943013530 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1117943013531 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1117943013532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1117943013533 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1117943013534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1117943013535 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1117943013536 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1117943013537 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1117943013538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943013539 active site 1117943013540 phosphorylation site [posttranslational modification] 1117943013541 intermolecular recognition site; other site 1117943013542 dimerization interface [polypeptide binding]; other site 1117943013543 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943013544 DNA binding site [nucleotide binding] 1117943013545 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1117943013546 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943013547 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943013548 dimer interface [polypeptide binding]; other site 1117943013549 phosphorylation site [posttranslational modification] 1117943013550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943013551 ATP binding site [chemical binding]; other site 1117943013552 Mg2+ binding site [ion binding]; other site 1117943013553 G-X-G motif; other site 1117943013554 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943013555 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943013556 TM-ABC transporter signature motif; other site 1117943013557 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1117943013558 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1117943013559 Walker A/P-loop; other site 1117943013560 ATP binding site [chemical binding]; other site 1117943013561 Q-loop/lid; other site 1117943013562 ABC transporter signature motif; other site 1117943013563 Walker B; other site 1117943013564 D-loop; other site 1117943013565 H-loop/switch region; other site 1117943013566 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1117943013567 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1117943013568 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1117943013569 putative ligand binding site [chemical binding]; other site 1117943013570 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 1117943013571 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1117943013572 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1117943013573 SnoaL-like domain; Region: SnoaL_3; pfam13474 1117943013574 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1117943013575 putative catalytic site [active] 1117943013576 putative phosphate binding site [ion binding]; other site 1117943013577 active site 1117943013578 metal binding site A [ion binding]; metal-binding site 1117943013579 DNA binding site [nucleotide binding] 1117943013580 putative AP binding site [nucleotide binding]; other site 1117943013581 putative metal binding site B [ion binding]; other site 1117943013582 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1117943013583 TPR repeat; Region: TPR_11; pfam13414 1117943013584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943013585 binding surface 1117943013586 TPR motif; other site 1117943013587 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 1117943013588 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1117943013589 putative DNA binding site [nucleotide binding]; other site 1117943013590 putative homodimer interface [polypeptide binding]; other site 1117943013591 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 1117943013592 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1117943013593 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1117943013594 active site 1117943013595 DNA binding site [nucleotide binding] 1117943013596 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1117943013597 DNA binding site [nucleotide binding] 1117943013598 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 1117943013599 nucleotide binding site [chemical binding]; other site 1117943013600 hypothetical protein; Provisional; Region: PRK11171 1117943013601 Cupin domain; Region: Cupin_2; pfam07883 1117943013602 Cupin domain; Region: Cupin_2; pfam07883 1117943013603 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 1117943013604 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1117943013605 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1117943013606 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943013607 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 1117943013608 putative dimerization interface [polypeptide binding]; other site 1117943013609 putative substrate binding pocket [chemical binding]; other site 1117943013610 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1117943013611 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1117943013612 Bacterial transcriptional regulator; Region: IclR; pfam01614 1117943013613 glyoxylate carboligase; Provisional; Region: PRK11269 1117943013614 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1117943013615 PYR/PP interface [polypeptide binding]; other site 1117943013616 dimer interface [polypeptide binding]; other site 1117943013617 TPP binding site [chemical binding]; other site 1117943013618 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1117943013619 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 1117943013620 TPP-binding site [chemical binding]; other site 1117943013621 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1117943013622 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1117943013623 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1117943013624 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1117943013625 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1117943013626 MOFRL family; Region: MOFRL; pfam05161 1117943013627 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1117943013628 ureidoglycolate hydrolase; Provisional; Region: PRK13395 1117943013629 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 1117943013630 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943013631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1117943013632 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1117943013633 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1117943013634 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1117943013635 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1117943013636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943013637 putative substrate translocation pore; other site 1117943013638 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1117943013639 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943013640 DNA binding site [nucleotide binding] 1117943013641 domain linker motif; other site 1117943013642 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1117943013643 putative dimerization interface [polypeptide binding]; other site 1117943013644 putative ligand binding site [chemical binding]; other site 1117943013645 putative aldolase; Validated; Region: PRK08130 1117943013646 intersubunit interface [polypeptide binding]; other site 1117943013647 active site 1117943013648 Zn2+ binding site [ion binding]; other site 1117943013649 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1117943013650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943013651 DNA-binding site [nucleotide binding]; DNA binding site 1117943013652 FCD domain; Region: FCD; pfam07729 1117943013653 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1117943013654 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1117943013655 putative NAD(P) binding site [chemical binding]; other site 1117943013656 active site 1117943013657 putative substrate binding site [chemical binding]; other site 1117943013658 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1117943013659 classical (c) SDRs; Region: SDR_c; cd05233 1117943013660 NAD(P) binding site [chemical binding]; other site 1117943013661 active site 1117943013662 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1117943013663 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943013664 Walker A/P-loop; other site 1117943013665 ATP binding site [chemical binding]; other site 1117943013666 Q-loop/lid; other site 1117943013667 ABC transporter signature motif; other site 1117943013668 Walker B; other site 1117943013669 D-loop; other site 1117943013670 H-loop/switch region; other site 1117943013671 TOBE domain; Region: TOBE; pfam03459 1117943013672 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943013673 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943013674 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1117943013675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943013676 dimer interface [polypeptide binding]; other site 1117943013677 conserved gate region; other site 1117943013678 putative PBP binding loops; other site 1117943013679 ABC-ATPase subunit interface; other site 1117943013680 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943013681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943013682 dimer interface [polypeptide binding]; other site 1117943013683 conserved gate region; other site 1117943013684 putative PBP binding loops; other site 1117943013685 ABC-ATPase subunit interface; other site 1117943013686 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1117943013687 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1117943013688 active site 1117943013689 catalytic tetrad [active] 1117943013690 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1117943013691 dimer interface [polypeptide binding]; other site 1117943013692 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1117943013693 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1117943013694 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1117943013695 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1117943013696 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1117943013697 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1117943013698 tyrosine decarboxylase; Region: PLN02880 1117943013699 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1117943013700 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1117943013701 catalytic residue [active] 1117943013702 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1117943013703 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 1117943013704 tetramer interface [polypeptide binding]; other site 1117943013705 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 1117943013706 tetramer interface [polypeptide binding]; other site 1117943013707 active site 1117943013708 metal binding site [ion binding]; metal-binding site 1117943013709 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1117943013710 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1117943013711 NAD binding site [chemical binding]; other site 1117943013712 catalytic residues [active] 1117943013713 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1117943013714 putative substrate binding pocket [chemical binding]; other site 1117943013715 trimer interface [polypeptide binding]; other site 1117943013716 Flavin Reductases; Region: FlaRed; cl00801 1117943013717 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1117943013718 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1117943013719 Cupin domain; Region: Cupin_2; cl17218 1117943013720 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1117943013721 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943013722 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1117943013723 Phosphotransferase enzyme family; Region: APH; pfam01636 1117943013724 active site 1117943013725 ATP binding site [chemical binding]; other site 1117943013726 substrate binding site [chemical binding]; other site 1117943013727 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1117943013728 hypothetical protein; Provisional; Region: PRK07481 1117943013729 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1117943013730 inhibitor-cofactor binding pocket; inhibition site 1117943013731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943013732 catalytic residue [active] 1117943013733 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1117943013734 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943013735 motif II; other site 1117943013736 hypothetical protein; Provisional; Region: PRK02399 1117943013737 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 1117943013738 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1117943013739 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1117943013740 Bacterial transcriptional regulator; Region: IclR; pfam01614 1117943013741 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1117943013742 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1117943013743 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1117943013744 NAD(P) binding site [chemical binding]; other site 1117943013745 catalytic residues [active] 1117943013746 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1117943013747 Uncharacterized conserved protein [Function unknown]; Region: COG5482 1117943013748 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943013749 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943013750 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943013751 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943013752 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943013753 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1117943013754 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943013755 DNA binding residues [nucleotide binding] 1117943013756 dimerization interface [polypeptide binding]; other site 1117943013757 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1117943013758 putative catalytic residues [active] 1117943013759 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1117943013760 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1117943013761 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1117943013762 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 1117943013763 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1117943013764 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1117943013765 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1117943013766 Walker A/P-loop; other site 1117943013767 ATP binding site [chemical binding]; other site 1117943013768 Q-loop/lid; other site 1117943013769 ABC transporter signature motif; other site 1117943013770 Walker B; other site 1117943013771 D-loop; other site 1117943013772 H-loop/switch region; other site 1117943013773 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1117943013774 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 1117943013775 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 1117943013776 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 1117943013777 Cytochrome c; Region: Cytochrom_C; cl11414 1117943013778 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1117943013779 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 1117943013780 Family description; Region: DsbD_2; pfam13386 1117943013781 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 1117943013782 Cytochrome c; Region: Cytochrom_C; pfam00034 1117943013783 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1117943013784 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1117943013785 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1117943013786 Low-spin heme binding site [chemical binding]; other site 1117943013787 D-pathway; other site 1117943013788 Putative water exit pathway; other site 1117943013789 Binuclear center (active site) [active] 1117943013790 K-pathway; other site 1117943013791 Putative proton exit pathway; other site 1117943013792 Cytochrome c [Energy production and conversion]; Region: COG3258 1117943013793 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1117943013794 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1117943013795 active site 1117943013796 metal binding site [ion binding]; metal-binding site 1117943013797 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1117943013798 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1117943013799 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1117943013800 Cu(I) binding site [ion binding]; other site 1117943013801 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1117943013802 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1117943013803 substrate-cofactor binding pocket; other site 1117943013804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943013805 catalytic residue [active] 1117943013806 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1117943013807 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1117943013808 ring oligomerisation interface [polypeptide binding]; other site 1117943013809 ATP/Mg binding site [chemical binding]; other site 1117943013810 stacking interactions; other site 1117943013811 hinge regions; other site 1117943013812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943013813 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943013814 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943013815 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943013816 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943013817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943013818 Cupin domain; Region: Cupin_2; pfam07883 1117943013819 cyclase homology domain; Region: CHD; cd07302 1117943013820 dimer interface [polypeptide binding]; other site 1117943013821 nucleotidyl binding site; other site 1117943013822 metal binding site [ion binding]; metal-binding site 1117943013823 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1117943013824 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1117943013825 YcfA-like protein; Region: YcfA; pfam07927 1117943013826 Cache domain; Region: Cache_1; pfam02743 1117943013827 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943013828 dimerization interface [polypeptide binding]; other site 1117943013829 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943013830 PAS fold; Region: PAS_3; pfam08447 1117943013831 putative active site [active] 1117943013832 heme pocket [chemical binding]; other site 1117943013833 PAS domain S-box; Region: sensory_box; TIGR00229 1117943013834 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943013835 putative active site [active] 1117943013836 heme pocket [chemical binding]; other site 1117943013837 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943013838 PAS fold; Region: PAS_3; pfam08447 1117943013839 putative active site [active] 1117943013840 heme pocket [chemical binding]; other site 1117943013841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943013842 dimer interface [polypeptide binding]; other site 1117943013843 phosphorylation site [posttranslational modification] 1117943013844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943013845 ATP binding site [chemical binding]; other site 1117943013846 Mg2+ binding site [ion binding]; other site 1117943013847 G-X-G motif; other site 1117943013848 Response regulator receiver domain; Region: Response_reg; pfam00072 1117943013849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943013850 active site 1117943013851 phosphorylation site [posttranslational modification] 1117943013852 intermolecular recognition site; other site 1117943013853 dimerization interface [polypeptide binding]; other site 1117943013854 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1117943013855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943013856 active site 1117943013857 phosphorylation site [posttranslational modification] 1117943013858 intermolecular recognition site; other site 1117943013859 dimerization interface [polypeptide binding]; other site 1117943013860 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943013861 DNA binding residues [nucleotide binding] 1117943013862 dimerization interface [polypeptide binding]; other site 1117943013863 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943013864 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1117943013865 TM-ABC transporter signature motif; other site 1117943013866 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943013867 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1117943013868 TM-ABC transporter signature motif; other site 1117943013869 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1117943013870 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943013871 Walker A/P-loop; other site 1117943013872 ATP binding site [chemical binding]; other site 1117943013873 Q-loop/lid; other site 1117943013874 ABC transporter signature motif; other site 1117943013875 Walker B; other site 1117943013876 D-loop; other site 1117943013877 H-loop/switch region; other site 1117943013878 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1117943013879 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1117943013880 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1117943013881 putative ligand binding site [chemical binding]; other site 1117943013882 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943013883 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943013884 non-specific DNA binding site [nucleotide binding]; other site 1117943013885 salt bridge; other site 1117943013886 sequence-specific DNA binding site [nucleotide binding]; other site 1117943013887 YceI-like domain; Region: YceI; cl01001 1117943013888 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1117943013889 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1117943013890 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1117943013891 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943013892 DNA-binding site [nucleotide binding]; DNA binding site 1117943013893 FCD domain; Region: FCD; cl11656 1117943013894 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1117943013895 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1117943013896 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1117943013897 DctM-like transporters; Region: DctM; pfam06808 1117943013898 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1117943013899 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1117943013900 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1117943013901 putative NAD(P) binding site [chemical binding]; other site 1117943013902 catalytic Zn binding site [ion binding]; other site 1117943013903 mannonate dehydratase; Provisional; Region: PRK03906 1117943013904 mannonate dehydratase; Region: uxuA; TIGR00695 1117943013905 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1117943013906 Protein export membrane protein; Region: SecD_SecF; cl14618 1117943013907 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1117943013908 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1117943013909 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943013910 hypothetical protein; Provisional; Region: PLN03153 1117943013911 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1117943013912 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1117943013913 active site 1117943013914 dimer interface [polypeptide binding]; other site 1117943013915 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1117943013916 Ligand Binding Site [chemical binding]; other site 1117943013917 Molecular Tunnel; other site 1117943013918 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1117943013919 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 1117943013920 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1117943013921 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 1117943013922 acyl-activating enzyme (AAE) consensus motif; other site 1117943013923 putative AMP binding site [chemical binding]; other site 1117943013924 putative active site [active] 1117943013925 putative CoA binding site [chemical binding]; other site 1117943013926 NAD synthetase; Reviewed; Region: nadE; PRK00876 1117943013927 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1117943013928 homodimer interface [polypeptide binding]; other site 1117943013929 NAD binding pocket [chemical binding]; other site 1117943013930 ATP binding pocket [chemical binding]; other site 1117943013931 Mg binding site [ion binding]; other site 1117943013932 active-site loop [active] 1117943013933 septum formation inhibitor; Reviewed; Region: minC; PRK05177 1117943013934 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1117943013935 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1117943013936 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1117943013937 Switch I; other site 1117943013938 Switch II; other site 1117943013939 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1117943013940 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1117943013941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943013942 S-adenosylmethionine binding site [chemical binding]; other site 1117943013943 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1117943013944 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1117943013945 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1117943013946 Chain length determinant protein; Region: Wzz; cl15801 1117943013947 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1117943013948 O-Antigen ligase; Region: Wzy_C; pfam04932 1117943013949 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1117943013950 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 1117943013951 putative active site [active] 1117943013952 putative metal binding site [ion binding]; other site 1117943013953 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1117943013954 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1117943013955 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1117943013956 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1117943013957 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1117943013958 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1117943013959 active site 1117943013960 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1117943013961 HAMP domain; Region: HAMP; pfam00672 1117943013962 dimerization interface [polypeptide binding]; other site 1117943013963 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1117943013964 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1117943013965 dimer interface [polypeptide binding]; other site 1117943013966 putative CheW interface [polypeptide binding]; other site 1117943013967 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1117943013968 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1117943013969 TadE-like protein; Region: TadE; pfam07811 1117943013970 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1117943013971 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 1117943013972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943013973 Q-loop/lid; other site 1117943013974 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1117943013975 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943013976 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943013977 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943013978 non-specific DNA binding site [nucleotide binding]; other site 1117943013979 salt bridge; other site 1117943013980 sequence-specific DNA binding site [nucleotide binding]; other site 1117943013981 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1117943013982 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1117943013983 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1117943013984 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943013985 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1117943013986 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943013987 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1117943013988 active site 1117943013989 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1117943013990 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 1117943013991 Amidinotransferase; Region: Amidinotransf; pfam02274 1117943013992 ornithine cyclodeaminase; Validated; Region: PRK07589 1117943013993 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1117943013994 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943013995 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1117943013996 putative DNA binding site [nucleotide binding]; other site 1117943013997 putative Zn2+ binding site [ion binding]; other site 1117943013998 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943013999 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 1117943014000 Protein of unknown function (DUF992); Region: DUF992; pfam06186 1117943014001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943014002 S-adenosylmethionine binding site [chemical binding]; other site 1117943014003 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1117943014004 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 1117943014005 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1117943014006 Subunit I/III interface [polypeptide binding]; other site 1117943014007 Subunit III/IV interface [polypeptide binding]; other site 1117943014008 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1117943014009 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1117943014010 D-pathway; other site 1117943014011 Putative ubiquinol binding site [chemical binding]; other site 1117943014012 Low-spin heme (heme b) binding site [chemical binding]; other site 1117943014013 Putative water exit pathway; other site 1117943014014 Binuclear center (heme o3/CuB) [ion binding]; other site 1117943014015 K-pathway; other site 1117943014016 Putative proton exit pathway; other site 1117943014017 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1117943014018 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1117943014019 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1117943014020 metabolite-proton symporter; Region: 2A0106; TIGR00883 1117943014021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943014022 putative substrate translocation pore; other site 1117943014023 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1117943014024 Domain of unknown function DUF21; Region: DUF21; pfam01595 1117943014025 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1117943014026 Transporter associated domain; Region: CorC_HlyC; smart01091 1117943014027 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 1117943014028 RNA polymerase sigma factor; Provisional; Region: PRK12547 1117943014029 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1117943014030 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1117943014031 DNA binding residues [nucleotide binding] 1117943014032 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 1117943014033 FOG: CBS domain [General function prediction only]; Region: COG0517 1117943014034 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1117943014035 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1117943014036 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1117943014037 classical (c) SDRs; Region: SDR_c; cd05233 1117943014038 NAD(P) binding site [chemical binding]; other site 1117943014039 active site 1117943014040 Low affinity iron permease; Region: Iron_permease; pfam04120 1117943014041 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1117943014042 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1117943014043 hypothetical protein; Provisional; Region: PRK14013 1117943014044 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1117943014045 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943014046 DNA binding site [nucleotide binding] 1117943014047 domain linker motif; other site 1117943014048 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1117943014049 dimerization interface [polypeptide binding]; other site 1117943014050 ligand binding site [chemical binding]; other site 1117943014051 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943014052 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943014053 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1117943014054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014055 putative PBP binding loops; other site 1117943014056 ABC-ATPase subunit interface; other site 1117943014057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1117943014058 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1117943014059 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1117943014060 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943014061 Walker A/P-loop; other site 1117943014062 ATP binding site [chemical binding]; other site 1117943014063 Q-loop/lid; other site 1117943014064 ABC transporter signature motif; other site 1117943014065 Walker B; other site 1117943014066 D-loop; other site 1117943014067 H-loop/switch region; other site 1117943014068 TOBE domain; Region: TOBE_2; pfam08402 1117943014069 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1117943014070 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943014071 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1117943014072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1117943014073 active site 1117943014074 dimerization interface [polypeptide binding]; other site 1117943014075 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943014076 DNA binding residues [nucleotide binding] 1117943014077 dimerization interface [polypeptide binding]; other site 1117943014078 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1117943014079 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943014080 DNA binding residues [nucleotide binding] 1117943014081 dimerization interface [polypeptide binding]; other site 1117943014082 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1117943014083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1117943014084 active site 1117943014085 phosphorylation site [posttranslational modification] 1117943014086 intermolecular recognition site; other site 1117943014087 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943014088 DNA binding residues [nucleotide binding] 1117943014089 dimerization interface [polypeptide binding]; other site 1117943014090 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1117943014091 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943014092 dimerization interface [polypeptide binding]; other site 1117943014093 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1117943014094 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1117943014095 dimer interface [polypeptide binding]; other site 1117943014096 putative CheW interface [polypeptide binding]; other site 1117943014097 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1117943014098 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943014099 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1117943014100 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1117943014101 putative active site [active] 1117943014102 putative metal binding site [ion binding]; other site 1117943014103 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1117943014104 Beta-lactamase; Region: Beta-lactamase; pfam00144 1117943014105 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1117943014106 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1117943014107 dimer interface [polypeptide binding]; other site 1117943014108 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1117943014109 catalytic triad [active] 1117943014110 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1117943014111 dimer interface [polypeptide binding]; other site 1117943014112 substrate binding site [chemical binding]; other site 1117943014113 ATP binding site [chemical binding]; other site 1117943014114 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 1117943014115 Chain length determinant protein; Region: Wzz; pfam02706 1117943014116 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1117943014117 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1117943014118 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1117943014119 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1117943014120 active site 1117943014121 tetramer interface; other site 1117943014122 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1117943014123 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1117943014124 active site 1117943014125 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1117943014126 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1117943014127 active site 1117943014128 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1117943014129 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 1117943014130 Ligand binding site; other site 1117943014131 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1117943014132 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1117943014133 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1117943014134 active site 1117943014135 active site 1117943014136 catalytic residues [active] 1117943014137 Staphylococcal nuclease homologues; Region: SNc; smart00318 1117943014138 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1117943014139 Catalytic site; other site 1117943014140 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1117943014141 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1117943014142 active site 1117943014143 Exopolysaccharide production repressor; Region: SyrA; pfam11089 1117943014144 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1117943014145 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1117943014146 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1117943014147 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1117943014148 O-Antigen ligase; Region: Wzy_C; pfam04932 1117943014149 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1117943014150 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1117943014151 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1117943014152 NAD binding site [chemical binding]; other site 1117943014153 homodimer interface [polypeptide binding]; other site 1117943014154 active site 1117943014155 substrate binding site [chemical binding]; other site 1117943014156 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1117943014157 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1117943014158 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1117943014159 Walker A/P-loop; other site 1117943014160 ATP binding site [chemical binding]; other site 1117943014161 Q-loop/lid; other site 1117943014162 ABC transporter signature motif; other site 1117943014163 Walker B; other site 1117943014164 D-loop; other site 1117943014165 H-loop/switch region; other site 1117943014166 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1117943014167 Ligand Binding Site [chemical binding]; other site 1117943014168 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1117943014169 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1117943014170 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1117943014171 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1117943014172 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1117943014173 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943014174 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943014175 sequence-specific DNA binding site [nucleotide binding]; other site 1117943014176 salt bridge; other site 1117943014177 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1117943014178 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1117943014179 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1117943014180 SnoaL-like domain; Region: SnoaL_2; pfam12680 1117943014181 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1117943014182 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1117943014183 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943014184 dimerization interface [polypeptide binding]; other site 1117943014185 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1117943014186 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1117943014187 dimer interface [polypeptide binding]; other site 1117943014188 putative CheW interface [polypeptide binding]; other site 1117943014189 Predicted transcriptional regulator [Transcription]; Region: COG1959 1117943014190 Transcriptional regulator; Region: Rrf2; pfam02082 1117943014191 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1117943014192 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1117943014193 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1117943014194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943014195 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1117943014196 NAD(P) binding site [chemical binding]; other site 1117943014197 active site 1117943014198 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1117943014199 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1117943014200 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943014201 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943014202 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1117943014203 putative effector binding pocket; other site 1117943014204 dimerization interface [polypeptide binding]; other site 1117943014205 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1117943014206 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943014207 Walker A/P-loop; other site 1117943014208 ATP binding site [chemical binding]; other site 1117943014209 Q-loop/lid; other site 1117943014210 ABC transporter signature motif; other site 1117943014211 Walker B; other site 1117943014212 D-loop; other site 1117943014213 H-loop/switch region; other site 1117943014214 TOBE domain; Region: TOBE_2; pfam08402 1117943014215 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943014216 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943014217 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1117943014218 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943014219 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943014220 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943014221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014222 dimer interface [polypeptide binding]; other site 1117943014223 conserved gate region; other site 1117943014224 putative PBP binding loops; other site 1117943014225 ABC-ATPase subunit interface; other site 1117943014226 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1117943014227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014228 dimer interface [polypeptide binding]; other site 1117943014229 conserved gate region; other site 1117943014230 putative PBP binding loops; other site 1117943014231 ABC-ATPase subunit interface; other site 1117943014232 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943014233 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943014234 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1117943014235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943014236 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943014237 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943014238 Protein of unknown function (DUF993); Region: DUF993; pfam06187 1117943014239 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1117943014240 metal binding site [ion binding]; metal-binding site 1117943014241 substrate binding pocket [chemical binding]; other site 1117943014242 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1117943014243 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943014244 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943014245 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1117943014246 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 1117943014247 putative active site [active] 1117943014248 Protein of unknown function (DUF995); Region: DUF995; pfam06191 1117943014249 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 1117943014250 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1117943014251 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1117943014252 active site 1117943014253 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1117943014254 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1117943014255 NAD binding site [chemical binding]; other site 1117943014256 homodimer interface [polypeptide binding]; other site 1117943014257 active site 1117943014258 substrate binding site [chemical binding]; other site 1117943014259 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1117943014260 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1117943014261 NAD binding site [chemical binding]; other site 1117943014262 putative substrate binding site 2 [chemical binding]; other site 1117943014263 putative substrate binding site 1 [chemical binding]; other site 1117943014264 active site 1117943014265 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1117943014266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943014267 Uncharacterized conserved protein [Function unknown]; Region: COG5439 1117943014268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 1117943014269 Cache domain; Region: Cache_1; pfam02743 1117943014270 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1117943014271 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943014272 dimerization interface [polypeptide binding]; other site 1117943014273 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1117943014274 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1117943014275 Uncharacterized conserved protein [Function unknown]; Region: COG5439 1117943014276 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1117943014277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943014278 S-adenosylmethionine binding site [chemical binding]; other site 1117943014279 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943014280 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943014281 metal binding site [ion binding]; metal-binding site 1117943014282 active site 1117943014283 I-site; other site 1117943014284 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1117943014285 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1117943014286 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943014287 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1117943014288 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1117943014289 DXD motif; other site 1117943014290 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1117943014291 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943014292 DNA binding site [nucleotide binding] 1117943014293 domain linker motif; other site 1117943014294 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1117943014295 ligand binding site [chemical binding]; other site 1117943014296 dimerization interface [polypeptide binding]; other site 1117943014297 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943014298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014299 dimer interface [polypeptide binding]; other site 1117943014300 conserved gate region; other site 1117943014301 putative PBP binding loops; other site 1117943014302 ABC-ATPase subunit interface; other site 1117943014303 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1117943014304 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1117943014305 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943014306 Walker A/P-loop; other site 1117943014307 ATP binding site [chemical binding]; other site 1117943014308 Q-loop/lid; other site 1117943014309 ABC transporter signature motif; other site 1117943014310 Walker B; other site 1117943014311 D-loop; other site 1117943014312 H-loop/switch region; other site 1117943014313 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1117943014314 Right handed beta helix region; Region: Beta_helix; pfam13229 1117943014315 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1117943014316 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943014317 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943014318 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1117943014319 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 1117943014320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943014321 NAD(P) binding site [chemical binding]; other site 1117943014322 active site 1117943014323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1117943014324 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1117943014325 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1117943014326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014327 dimer interface [polypeptide binding]; other site 1117943014328 conserved gate region; other site 1117943014329 putative PBP binding loops; other site 1117943014330 ABC-ATPase subunit interface; other site 1117943014331 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 1117943014332 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1117943014333 Walker A/P-loop; other site 1117943014334 ATP binding site [chemical binding]; other site 1117943014335 Q-loop/lid; other site 1117943014336 ABC transporter signature motif; other site 1117943014337 Walker B; other site 1117943014338 D-loop; other site 1117943014339 H-loop/switch region; other site 1117943014340 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1117943014341 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943014342 substrate binding pocket [chemical binding]; other site 1117943014343 membrane-bound complex binding site; other site 1117943014344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1117943014345 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1117943014346 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1117943014347 DNA-binding site [nucleotide binding]; DNA binding site 1117943014348 RNA-binding motif; other site 1117943014349 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1117943014350 Ethanolamine utilisation protein EutA; Region: EutA; pfam06277 1117943014351 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1117943014352 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1117943014353 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1117943014354 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1117943014355 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943014356 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943014357 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1117943014358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014359 dimer interface [polypeptide binding]; other site 1117943014360 conserved gate region; other site 1117943014361 putative PBP binding loops; other site 1117943014362 ABC-ATPase subunit interface; other site 1117943014363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1117943014364 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943014365 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1117943014366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943014367 Walker A/P-loop; other site 1117943014368 ATP binding site [chemical binding]; other site 1117943014369 Q-loop/lid; other site 1117943014370 ABC transporter signature motif; other site 1117943014371 Walker B; other site 1117943014372 D-loop; other site 1117943014373 H-loop/switch region; other site 1117943014374 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1117943014375 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1117943014376 Walker A/P-loop; other site 1117943014377 ATP binding site [chemical binding]; other site 1117943014378 Q-loop/lid; other site 1117943014379 ABC transporter signature motif; other site 1117943014380 Walker B; other site 1117943014381 D-loop; other site 1117943014382 H-loop/switch region; other site 1117943014383 TOBE domain; Region: TOBE_2; pfam08402 1117943014384 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1117943014385 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1117943014386 putative N- and C-terminal domain interface [polypeptide binding]; other site 1117943014387 putative active site [active] 1117943014388 MgATP binding site [chemical binding]; other site 1117943014389 catalytic site [active] 1117943014390 metal binding site [ion binding]; metal-binding site 1117943014391 putative xylulose binding site [chemical binding]; other site 1117943014392 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1117943014393 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1117943014394 putative ligand binding site [chemical binding]; other site 1117943014395 putative NAD binding site [chemical binding]; other site 1117943014396 catalytic site [active] 1117943014397 Uncharacterized conserved protein [Function unknown]; Region: COG3347 1117943014398 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1117943014399 intersubunit interface [polypeptide binding]; other site 1117943014400 active site 1117943014401 Zn2+ binding site [ion binding]; other site 1117943014402 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1117943014403 D-xylulose kinase; Region: XylB; TIGR01312 1117943014404 nucleotide binding site [chemical binding]; other site 1117943014405 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1117943014406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943014407 active site 1117943014408 motif I; other site 1117943014409 motif II; other site 1117943014410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943014411 motif II; other site 1117943014412 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1117943014413 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1117943014414 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 1117943014415 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1117943014416 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1117943014417 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1117943014418 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1117943014419 substrate binding site [chemical binding]; other site 1117943014420 dimer interface [polypeptide binding]; other site 1117943014421 triosephosphate isomerase; Provisional; Region: PRK14565 1117943014422 catalytic triad [active] 1117943014423 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1117943014424 Cupin; Region: Cupin_6; pfam12852 1117943014425 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943014426 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1117943014427 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943014428 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1117943014429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943014430 putative substrate translocation pore; other site 1117943014431 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1117943014432 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1117943014433 active site 1117943014434 catalytic triad [active] 1117943014435 dimer interface [polypeptide binding]; other site 1117943014436 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1117943014437 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1117943014438 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1117943014439 active site 1117943014440 catalytic site [active] 1117943014441 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1117943014442 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 1117943014443 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1117943014444 putative active site [active] 1117943014445 putative active site [active] 1117943014446 catalytic site [active] 1117943014447 catalytic site [active] 1117943014448 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 1117943014449 putative active site [active] 1117943014450 catalytic site [active] 1117943014451 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1117943014452 putative catalytic site [active] 1117943014453 putative metal binding site [ion binding]; other site 1117943014454 putative phosphate binding site [ion binding]; other site 1117943014455 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1117943014456 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1117943014457 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1117943014458 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1117943014459 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1117943014460 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943014461 dimerization interface [polypeptide binding]; other site 1117943014462 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1117943014463 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1117943014464 dimer interface [polypeptide binding]; other site 1117943014465 putative CheW interface [polypeptide binding]; other site 1117943014466 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1117943014467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943014468 putative substrate translocation pore; other site 1117943014469 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1117943014470 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943014471 DNA-binding site [nucleotide binding]; DNA binding site 1117943014472 FCD domain; Region: FCD; pfam07729 1117943014473 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 1117943014474 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1117943014475 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943014476 Walker A/P-loop; other site 1117943014477 ATP binding site [chemical binding]; other site 1117943014478 Q-loop/lid; other site 1117943014479 ABC transporter signature motif; other site 1117943014480 Walker B; other site 1117943014481 D-loop; other site 1117943014482 H-loop/switch region; other site 1117943014483 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1117943014484 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1117943014485 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943014486 Walker A/P-loop; other site 1117943014487 ATP binding site [chemical binding]; other site 1117943014488 Q-loop/lid; other site 1117943014489 ABC transporter signature motif; other site 1117943014490 Walker B; other site 1117943014491 D-loop; other site 1117943014492 H-loop/switch region; other site 1117943014493 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1117943014494 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1117943014495 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1117943014496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014497 dimer interface [polypeptide binding]; other site 1117943014498 conserved gate region; other site 1117943014499 putative PBP binding loops; other site 1117943014500 ABC-ATPase subunit interface; other site 1117943014501 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1117943014502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014503 dimer interface [polypeptide binding]; other site 1117943014504 conserved gate region; other site 1117943014505 putative PBP binding loops; other site 1117943014506 ABC-ATPase subunit interface; other site 1117943014507 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1117943014508 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1117943014509 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1117943014510 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1117943014511 inhibitor site; inhibition site 1117943014512 active site 1117943014513 dimer interface [polypeptide binding]; other site 1117943014514 catalytic residue [active] 1117943014515 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 1117943014516 BNR repeat-like domain; Region: BNR_2; pfam13088 1117943014517 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 1117943014518 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1117943014519 putative active site [active] 1117943014520 metal binding site [ion binding]; metal-binding site 1117943014521 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1117943014522 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1117943014523 cytosine deaminase; Validated; Region: PRK07572 1117943014524 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1117943014525 active site 1117943014526 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1117943014527 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1117943014528 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943014529 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943014530 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1117943014531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943014532 NAD(P) binding site [chemical binding]; other site 1117943014533 active site 1117943014534 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1117943014535 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1117943014536 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1117943014537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943014538 NAD(P) binding site [chemical binding]; other site 1117943014539 active site 1117943014540 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 1117943014541 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1117943014542 nucleotide binding site [chemical binding]; other site 1117943014543 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1117943014544 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943014545 DNA binding site [nucleotide binding] 1117943014546 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1117943014547 putative ligand binding site [chemical binding]; other site 1117943014548 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1117943014549 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 1117943014550 putative di-iron ligands [ion binding]; other site 1117943014551 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1117943014552 [2Fe-2S] cluster binding site [ion binding]; other site 1117943014553 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1117943014554 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1117943014555 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1117943014556 Ketopantoate hydroxymethyltransferase [Coenzyme metabolism]; Region: PanB; COG0413 1117943014557 metal binding site [ion binding]; metal-binding site 1117943014558 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 1117943014559 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1117943014560 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1117943014561 putative active site [active] 1117943014562 putative substrate binding site [chemical binding]; other site 1117943014563 putative cosubstrate binding site; other site 1117943014564 catalytic site [active] 1117943014565 Amino acid synthesis; Region: AA_synth; pfam06684 1117943014566 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1117943014567 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1117943014568 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1117943014569 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1117943014570 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1117943014571 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1117943014572 NAD(P) binding site [chemical binding]; other site 1117943014573 catalytic residues [active] 1117943014574 NIPSNAP; Region: NIPSNAP; pfam07978 1117943014575 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1117943014576 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1117943014577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014578 dimer interface [polypeptide binding]; other site 1117943014579 conserved gate region; other site 1117943014580 putative PBP binding loops; other site 1117943014581 ABC-ATPase subunit interface; other site 1117943014582 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1117943014583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014584 dimer interface [polypeptide binding]; other site 1117943014585 conserved gate region; other site 1117943014586 putative PBP binding loops; other site 1117943014587 ABC-ATPase subunit interface; other site 1117943014588 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1117943014589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943014590 Walker A/P-loop; other site 1117943014591 ATP binding site [chemical binding]; other site 1117943014592 Q-loop/lid; other site 1117943014593 ABC transporter signature motif; other site 1117943014594 Walker B; other site 1117943014595 D-loop; other site 1117943014596 H-loop/switch region; other site 1117943014597 TOBE domain; Region: TOBE_2; pfam08402 1117943014598 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943014599 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943014600 DNA-binding site [nucleotide binding]; DNA binding site 1117943014601 FCD domain; Region: FCD; pfam07729 1117943014602 D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312 1117943014603 mannonate dehydratase; Region: uxuA; TIGR00695 1117943014604 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1117943014605 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943014606 DNA-binding site [nucleotide binding]; DNA binding site 1117943014607 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1117943014608 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1117943014609 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1117943014610 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1117943014611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014612 dimer interface [polypeptide binding]; other site 1117943014613 conserved gate region; other site 1117943014614 putative PBP binding loops; other site 1117943014615 ABC-ATPase subunit interface; other site 1117943014616 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1117943014617 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1117943014618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014619 ABC-ATPase subunit interface; other site 1117943014620 putative PBP binding loops; other site 1117943014621 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1117943014622 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943014623 Walker A/P-loop; other site 1117943014624 ATP binding site [chemical binding]; other site 1117943014625 Q-loop/lid; other site 1117943014626 ABC transporter signature motif; other site 1117943014627 Walker B; other site 1117943014628 D-loop; other site 1117943014629 H-loop/switch region; other site 1117943014630 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1117943014631 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1117943014632 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943014633 Walker A/P-loop; other site 1117943014634 ATP binding site [chemical binding]; other site 1117943014635 Q-loop/lid; other site 1117943014636 ABC transporter signature motif; other site 1117943014637 Walker B; other site 1117943014638 D-loop; other site 1117943014639 H-loop/switch region; other site 1117943014640 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1117943014641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943014642 active site 1117943014643 phosphorylation site [posttranslational modification] 1117943014644 intermolecular recognition site; other site 1117943014645 dimerization interface [polypeptide binding]; other site 1117943014646 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943014647 PAS domain; Region: PAS_9; pfam13426 1117943014648 putative active site [active] 1117943014649 heme pocket [chemical binding]; other site 1117943014650 PAS domain S-box; Region: sensory_box; TIGR00229 1117943014651 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943014652 putative active site [active] 1117943014653 heme pocket [chemical binding]; other site 1117943014654 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1117943014655 GAF domain; Region: GAF; pfam01590 1117943014656 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1117943014657 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1117943014658 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943014659 putative active site [active] 1117943014660 heme pocket [chemical binding]; other site 1117943014661 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1117943014662 HWE histidine kinase; Region: HWE_HK; pfam07536 1117943014663 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1117943014664 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1117943014665 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1117943014666 active site 1117943014667 catalytic residues [active] 1117943014668 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1117943014669 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1117943014670 ligand binding site [chemical binding]; other site 1117943014671 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1117943014672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943014673 NAD(P) binding site [chemical binding]; other site 1117943014674 active site 1117943014675 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1117943014676 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1117943014677 Walker A/P-loop; other site 1117943014678 ATP binding site [chemical binding]; other site 1117943014679 Q-loop/lid; other site 1117943014680 ABC transporter signature motif; other site 1117943014681 Walker B; other site 1117943014682 D-loop; other site 1117943014683 H-loop/switch region; other site 1117943014684 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943014685 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943014686 TM-ABC transporter signature motif; other site 1117943014687 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1117943014688 protein binding site [polypeptide binding]; other site 1117943014689 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 1117943014690 Domain interface; other site 1117943014691 Peptide binding site; other site 1117943014692 Active site tetrad [active] 1117943014693 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1117943014694 Peptidase family M50; Region: Peptidase_M50; pfam02163 1117943014695 active site 1117943014696 putative substrate binding region [chemical binding]; other site 1117943014697 FOG: CBS domain [General function prediction only]; Region: COG0517 1117943014698 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639 1117943014699 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1117943014700 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943014701 DNA binding site [nucleotide binding] 1117943014702 domain linker motif; other site 1117943014703 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1117943014704 ligand binding site [chemical binding]; other site 1117943014705 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943014706 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943014707 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1117943014708 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1117943014709 DNA interaction; other site 1117943014710 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943014711 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943014712 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1117943014713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014714 dimer interface [polypeptide binding]; other site 1117943014715 conserved gate region; other site 1117943014716 putative PBP binding loops; other site 1117943014717 ABC-ATPase subunit interface; other site 1117943014718 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943014719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014720 dimer interface [polypeptide binding]; other site 1117943014721 conserved gate region; other site 1117943014722 putative PBP binding loops; other site 1117943014723 ABC-ATPase subunit interface; other site 1117943014724 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1117943014725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943014726 Walker A/P-loop; other site 1117943014727 ATP binding site [chemical binding]; other site 1117943014728 Q-loop/lid; other site 1117943014729 ABC transporter signature motif; other site 1117943014730 Walker B; other site 1117943014731 D-loop; other site 1117943014732 H-loop/switch region; other site 1117943014733 TOBE domain; Region: TOBE_2; pfam08402 1117943014734 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1117943014735 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943014736 DNA-binding site [nucleotide binding]; DNA binding site 1117943014737 FCD domain; Region: FCD; pfam07729 1117943014738 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943014739 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943014740 TM-ABC transporter signature motif; other site 1117943014741 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943014742 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943014743 TM-ABC transporter signature motif; other site 1117943014744 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1117943014745 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1117943014746 Walker A/P-loop; other site 1117943014747 ATP binding site [chemical binding]; other site 1117943014748 Q-loop/lid; other site 1117943014749 ABC transporter signature motif; other site 1117943014750 Walker B; other site 1117943014751 D-loop; other site 1117943014752 H-loop/switch region; other site 1117943014753 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1117943014754 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1117943014755 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1117943014756 putative ligand binding site [chemical binding]; other site 1117943014757 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1117943014758 glutathione synthetase; Provisional; Region: PRK12458 1117943014759 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1117943014760 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 1117943014761 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 1117943014762 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1117943014763 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1117943014764 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1117943014765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014766 putative PBP binding loops; other site 1117943014767 ABC-ATPase subunit interface; other site 1117943014768 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1117943014769 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943014770 Walker A/P-loop; other site 1117943014771 ATP binding site [chemical binding]; other site 1117943014772 Q-loop/lid; other site 1117943014773 ABC transporter signature motif; other site 1117943014774 Walker B; other site 1117943014775 D-loop; other site 1117943014776 H-loop/switch region; other site 1117943014777 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943014778 Walker A/P-loop; other site 1117943014779 ATP binding site [chemical binding]; other site 1117943014780 Q-loop/lid; other site 1117943014781 ABC transporter signature motif; other site 1117943014782 Walker B; other site 1117943014783 D-loop; other site 1117943014784 H-loop/switch region; other site 1117943014785 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 1117943014786 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1117943014787 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 1117943014788 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 1117943014789 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1117943014790 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943014791 cyclase homology domain; Region: CHD; cd07302 1117943014792 nucleotidyl binding site; other site 1117943014793 metal binding site [ion binding]; metal-binding site 1117943014794 dimer interface [polypeptide binding]; other site 1117943014795 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943014796 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1117943014797 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943014798 TPR motif; other site 1117943014799 binding surface 1117943014800 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1117943014801 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1117943014802 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 1117943014803 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1117943014804 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 1117943014805 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 1117943014806 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1117943014807 DXD motif; other site 1117943014808 Cellulose synthase-like protein; Region: PLN02893 1117943014809 PilZ domain; Region: PilZ; pfam07238 1117943014810 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1117943014811 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943014812 Coenzyme A binding pocket [chemical binding]; other site 1117943014813 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943014814 dimerization interface [polypeptide binding]; other site 1117943014815 PAS fold; Region: PAS_7; pfam12860 1117943014816 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943014817 cyclase homology domain; Region: CHD; cd07302 1117943014818 nucleotidyl binding site; other site 1117943014819 metal binding site [ion binding]; metal-binding site 1117943014820 dimer interface [polypeptide binding]; other site 1117943014821 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1117943014822 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1117943014823 dimerization interface [polypeptide binding]; other site 1117943014824 ligand binding site [chemical binding]; other site 1117943014825 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1117943014826 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1117943014827 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1117943014828 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943014829 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943014830 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943014831 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943014832 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943014833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1117943014834 Coenzyme A binding pocket [chemical binding]; other site 1117943014835 hypothetical protein; Provisional; Region: PRK06148 1117943014836 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1117943014837 active site 1117943014838 ATP binding site [chemical binding]; other site 1117943014839 Peptidase family M23; Region: Peptidase_M23; pfam01551 1117943014840 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1117943014841 inhibitor-cofactor binding pocket; inhibition site 1117943014842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943014843 catalytic residue [active] 1117943014844 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943014845 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1117943014846 putative DNA binding site [nucleotide binding]; other site 1117943014847 putative Zn2+ binding site [ion binding]; other site 1117943014848 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943014849 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1117943014850 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 1117943014851 active site 1117943014852 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1117943014853 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943014854 Walker A/P-loop; other site 1117943014855 ATP binding site [chemical binding]; other site 1117943014856 Q-loop/lid; other site 1117943014857 ABC transporter signature motif; other site 1117943014858 Walker B; other site 1117943014859 D-loop; other site 1117943014860 H-loop/switch region; other site 1117943014861 TOBE domain; Region: TOBE_2; pfam08402 1117943014862 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1117943014863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014864 dimer interface [polypeptide binding]; other site 1117943014865 conserved gate region; other site 1117943014866 putative PBP binding loops; other site 1117943014867 ABC-ATPase subunit interface; other site 1117943014868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014869 dimer interface [polypeptide binding]; other site 1117943014870 conserved gate region; other site 1117943014871 putative PBP binding loops; other site 1117943014872 ABC-ATPase subunit interface; other site 1117943014873 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1117943014874 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1117943014875 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1117943014876 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943014877 DNA binding site [nucleotide binding] 1117943014878 domain linker motif; other site 1117943014879 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 1117943014880 putative dimerization interface [polypeptide binding]; other site 1117943014881 putative ligand binding site [chemical binding]; other site 1117943014882 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1117943014883 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1117943014884 Walker A/P-loop; other site 1117943014885 ATP binding site [chemical binding]; other site 1117943014886 Q-loop/lid; other site 1117943014887 ABC transporter signature motif; other site 1117943014888 Walker B; other site 1117943014889 D-loop; other site 1117943014890 H-loop/switch region; other site 1117943014891 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1117943014892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014893 putative PBP binding loops; other site 1117943014894 dimer interface [polypeptide binding]; other site 1117943014895 ABC-ATPase subunit interface; other site 1117943014896 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1117943014897 NMT1-like family; Region: NMT1_2; pfam13379 1117943014898 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1117943014899 Helix-turn-helix domain; Region: HTH_28; pfam13518 1117943014900 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943014901 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943014902 Integrase core domain; Region: rve; pfam00665 1117943014903 BA14K-like protein; Region: BA14K; pfam07886 1117943014904 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 1117943014905 manganese transport regulator MntR; Provisional; Region: PRK11050 1117943014906 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1117943014907 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1117943014908 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1117943014909 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1117943014910 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1117943014911 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1117943014912 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1117943014913 metal binding site [ion binding]; metal-binding site 1117943014914 substrate binding pocket [chemical binding]; other site 1117943014915 choline dehydrogenase; Validated; Region: PRK02106 1117943014916 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1117943014917 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1117943014918 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1117943014919 NAD(P) binding site [chemical binding]; other site 1117943014920 catalytic residues [active] 1117943014921 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1117943014922 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1117943014923 classical (c) SDRs; Region: SDR_c; cd05233 1117943014924 NAD(P) binding site [chemical binding]; other site 1117943014925 active site 1117943014926 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1117943014927 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1117943014928 active site pocket [active] 1117943014929 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1117943014930 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943014931 Walker A/P-loop; other site 1117943014932 ATP binding site [chemical binding]; other site 1117943014933 Q-loop/lid; other site 1117943014934 ABC transporter signature motif; other site 1117943014935 Walker B; other site 1117943014936 D-loop; other site 1117943014937 H-loop/switch region; other site 1117943014938 TOBE domain; Region: TOBE_2; pfam08402 1117943014939 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1117943014940 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1117943014941 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1117943014942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014943 dimer interface [polypeptide binding]; other site 1117943014944 conserved gate region; other site 1117943014945 putative PBP binding loops; other site 1117943014946 ABC-ATPase subunit interface; other site 1117943014947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943014948 dimer interface [polypeptide binding]; other site 1117943014949 conserved gate region; other site 1117943014950 putative PBP binding loops; other site 1117943014951 ABC-ATPase subunit interface; other site 1117943014952 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943014953 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943014954 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943014955 dimerization interface [polypeptide binding]; other site 1117943014956 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1117943014957 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1117943014958 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1117943014959 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1117943014960 potassium uptake protein; Region: kup; TIGR00794 1117943014961 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 1117943014962 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1117943014963 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943014964 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943014965 metal binding site [ion binding]; metal-binding site 1117943014966 active site 1117943014967 I-site; other site 1117943014968 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1117943014969 Part of AAA domain; Region: AAA_19; pfam13245 1117943014970 Family description; Region: UvrD_C_2; pfam13538 1117943014971 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1117943014972 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1117943014973 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1117943014974 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943014975 motif II; other site 1117943014976 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1117943014977 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1117943014978 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 1117943014979 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1117943014980 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1117943014981 active site 1117943014982 metal binding site [ion binding]; metal-binding site 1117943014983 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 1117943014984 HPP family; Region: HPP; pfam04982 1117943014985 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1117943014986 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 1117943014987 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1117943014988 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943014989 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1117943014990 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1117943014991 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1117943014992 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943014993 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1117943014994 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1117943014995 Walker A/P-loop; other site 1117943014996 ATP binding site [chemical binding]; other site 1117943014997 Q-loop/lid; other site 1117943014998 ABC transporter signature motif; other site 1117943014999 Walker B; other site 1117943015000 D-loop; other site 1117943015001 H-loop/switch region; other site 1117943015002 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1117943015003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943015004 Walker A/P-loop; other site 1117943015005 ATP binding site [chemical binding]; other site 1117943015006 Q-loop/lid; other site 1117943015007 ABC transporter signature motif; other site 1117943015008 Walker B; other site 1117943015009 D-loop; other site 1117943015010 H-loop/switch region; other site 1117943015011 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1117943015012 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1117943015013 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1117943015014 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1117943015015 Predicted esterase [General function prediction only]; Region: COG0400 1117943015016 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1117943015017 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1117943015018 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943015019 Zn binding site [ion binding]; other site 1117943015020 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1117943015021 Zn binding site [ion binding]; other site 1117943015022 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1117943015023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943015024 dimer interface [polypeptide binding]; other site 1117943015025 phosphorylation site [posttranslational modification] 1117943015026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943015027 ATP binding site [chemical binding]; other site 1117943015028 Mg2+ binding site [ion binding]; other site 1117943015029 G-X-G motif; other site 1117943015030 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1117943015031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943015032 active site 1117943015033 phosphorylation site [posttranslational modification] 1117943015034 intermolecular recognition site; other site 1117943015035 dimerization interface [polypeptide binding]; other site 1117943015036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943015037 Walker A motif; other site 1117943015038 ATP binding site [chemical binding]; other site 1117943015039 Walker B motif; other site 1117943015040 arginine finger; other site 1117943015041 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1117943015042 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1117943015043 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1117943015044 Substrate binding site; other site 1117943015045 Cupin domain; Region: Cupin_2; cl17218 1117943015046 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1117943015047 dimerization interface [polypeptide binding]; other site 1117943015048 putative active cleft [active] 1117943015049 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1117943015050 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1117943015051 active site 1117943015052 substrate binding site [chemical binding]; other site 1117943015053 metal binding site [ion binding]; metal-binding site 1117943015054 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1117943015055 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943015056 DNA binding residues [nucleotide binding] 1117943015057 dimerization interface [polypeptide binding]; other site 1117943015058 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1117943015059 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1117943015060 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1117943015061 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1117943015062 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1117943015063 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1117943015064 putative ADP-binding pocket [chemical binding]; other site 1117943015065 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1117943015066 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1117943015067 SLBB domain; Region: SLBB; pfam10531 1117943015068 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1117943015069 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943015070 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943015071 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1117943015072 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1117943015073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943015074 Walker A motif; other site 1117943015075 ATP binding site [chemical binding]; other site 1117943015076 Walker B motif; other site 1117943015077 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1117943015078 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943015079 Integrase core domain; Region: rve; pfam00665 1117943015080 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943015081 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1117943015082 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943015083 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943015084 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943015085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943015086 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943015087 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 1117943015088 Chain length determinant protein; Region: Wzz; pfam02706 1117943015089 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1117943015090 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1117943015091 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943015092 Walker A/P-loop; other site 1117943015093 ATP binding site [chemical binding]; other site 1117943015094 Q-loop/lid; other site 1117943015095 ABC transporter signature motif; other site 1117943015096 Walker B; other site 1117943015097 D-loop; other site 1117943015098 H-loop/switch region; other site 1117943015099 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1117943015100 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943015101 Walker A/P-loop; other site 1117943015102 ATP binding site [chemical binding]; other site 1117943015103 Q-loop/lid; other site 1117943015104 ABC transporter signature motif; other site 1117943015105 Walker B; other site 1117943015106 D-loop; other site 1117943015107 H-loop/switch region; other site 1117943015108 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1117943015109 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1117943015110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943015111 dimer interface [polypeptide binding]; other site 1117943015112 conserved gate region; other site 1117943015113 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1117943015114 ABC-ATPase subunit interface; other site 1117943015115 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1117943015116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943015117 dimer interface [polypeptide binding]; other site 1117943015118 conserved gate region; other site 1117943015119 putative PBP binding loops; other site 1117943015120 ABC-ATPase subunit interface; other site 1117943015121 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1117943015122 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1117943015123 peptide binding site [polypeptide binding]; other site 1117943015124 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1117943015125 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1117943015126 intersubunit interface [polypeptide binding]; other site 1117943015127 active site 1117943015128 zinc binding site [ion binding]; other site 1117943015129 Na+ binding site [ion binding]; other site 1117943015130 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1117943015131 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1117943015132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943015133 Walker A/P-loop; other site 1117943015134 ATP binding site [chemical binding]; other site 1117943015135 Q-loop/lid; other site 1117943015136 ABC transporter signature motif; other site 1117943015137 Walker B; other site 1117943015138 D-loop; other site 1117943015139 H-loop/switch region; other site 1117943015140 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1117943015141 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1117943015142 active site 1117943015143 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1117943015144 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1117943015145 active site 1117943015146 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1117943015147 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1117943015148 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1117943015149 DNA binding residues [nucleotide binding] 1117943015150 dimer interface [polypeptide binding]; other site 1117943015151 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1117943015152 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943015153 non-specific DNA binding site [nucleotide binding]; other site 1117943015154 salt bridge; other site 1117943015155 sequence-specific DNA binding site [nucleotide binding]; other site 1117943015156 Cupin domain; Region: Cupin_2; pfam07883 1117943015157 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 1117943015158 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1117943015159 inhibitor-cofactor binding pocket; inhibition site 1117943015160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943015161 catalytic residue [active] 1117943015162 succinic semialdehyde dehydrogenase; Region: PLN02278 1117943015163 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1117943015164 tetramerization interface [polypeptide binding]; other site 1117943015165 NAD(P) binding site [chemical binding]; other site 1117943015166 catalytic residues [active] 1117943015167 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 1117943015168 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1117943015169 NAD binding site [chemical binding]; other site 1117943015170 homotetramer interface [polypeptide binding]; other site 1117943015171 homodimer interface [polypeptide binding]; other site 1117943015172 substrate binding site [chemical binding]; other site 1117943015173 active site 1117943015174 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1117943015175 propionate/acetate kinase; Provisional; Region: PRK12379 1117943015176 phosphate acetyltransferase; Provisional; Region: PRK11890 1117943015177 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 1117943015178 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 1117943015179 heat shock protein 90; Provisional; Region: PRK05218 1117943015180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943015181 ATP binding site [chemical binding]; other site 1117943015182 Mg2+ binding site [ion binding]; other site 1117943015183 G-X-G motif; other site 1117943015184 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1117943015185 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 1117943015186 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1117943015187 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 1117943015188 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 1117943015189 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1117943015190 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1117943015191 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1117943015192 catalytic residue [active] 1117943015193 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1117943015194 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1117943015195 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1117943015196 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1117943015197 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1117943015198 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1117943015199 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1117943015200 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1117943015201 active site 1117943015202 Transposase domain (DUF772); Region: DUF772; pfam05598 1117943015203 transposase; Validated; Region: PRK08181 1117943015204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943015205 Walker A motif; other site 1117943015206 ATP binding site [chemical binding]; other site 1117943015207 Integrase core domain; Region: rve; pfam00665 1117943015208 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943015209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943015210 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943015211 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1117943015212 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1117943015213 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1117943015214 active site 1117943015215 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1117943015216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943015217 S-adenosylmethionine binding site [chemical binding]; other site 1117943015218 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1117943015219 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1117943015220 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1117943015221 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1117943015222 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 1117943015223 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1117943015224 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1117943015225 catalytic residue [active] 1117943015226 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1117943015227 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1117943015228 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1117943015229 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1117943015230 active site 1117943015231 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1117943015232 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1117943015233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943015234 S-adenosylmethionine binding site [chemical binding]; other site 1117943015235 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1117943015236 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1117943015237 Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain [General function prediction only]; Region: COG4310 1117943015238 M28 Zn-Peptidases; Region: M28_like_3; cd05644 1117943015239 active site 1117943015240 metal binding site [ion binding]; metal-binding site 1117943015241 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1117943015242 extended (e) SDRs; Region: SDR_e; cd08946 1117943015243 NAD(P) binding site [chemical binding]; other site 1117943015244 active site 1117943015245 substrate binding site [chemical binding]; other site 1117943015246 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1117943015247 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1117943015248 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1117943015249 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1117943015250 FAD binding site [chemical binding]; other site 1117943015251 substrate binding pocket [chemical binding]; other site 1117943015252 catalytic base [active] 1117943015253 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1117943015254 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1117943015255 Walker A/P-loop; other site 1117943015256 ATP binding site [chemical binding]; other site 1117943015257 Q-loop/lid; other site 1117943015258 ABC transporter signature motif; other site 1117943015259 Walker B; other site 1117943015260 D-loop; other site 1117943015261 H-loop/switch region; other site 1117943015262 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 1117943015263 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1117943015264 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1117943015265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943015266 dimer interface [polypeptide binding]; other site 1117943015267 conserved gate region; other site 1117943015268 ABC-ATPase subunit interface; other site 1117943015269 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1117943015270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943015271 dimer interface [polypeptide binding]; other site 1117943015272 conserved gate region; other site 1117943015273 ABC-ATPase subunit interface; other site 1117943015274 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 1117943015275 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 1117943015276 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1117943015277 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1117943015278 active site 1117943015279 Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709 1117943015280 AAA domain; Region: AAA_33; pfam13671 1117943015281 active site 1117943015282 imidazolonepropionase; Validated; Region: PRK09356 1117943015283 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1117943015284 active site 1117943015285 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1117943015286 active sites [active] 1117943015287 tetramer interface [polypeptide binding]; other site 1117943015288 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1117943015289 urocanate hydratase; Provisional; Region: PRK05414 1117943015290 sugar efflux transporter; Region: 2A0120; TIGR00899 1117943015291 Uncharacterized conserved protein [Function unknown]; Region: COG5476 1117943015292 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 1117943015293 MlrC C-terminus; Region: MlrC_C; pfam07171 1117943015294 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 1117943015295 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1117943015296 active site 1117943015297 short chain dehydrogenase; Provisional; Region: PRK07074 1117943015298 classical (c) SDRs; Region: SDR_c; cd05233 1117943015299 NAD(P) binding site [chemical binding]; other site 1117943015300 active site 1117943015301 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1117943015302 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1117943015303 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1117943015304 putative active site [active] 1117943015305 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1117943015306 homotrimer interaction site [polypeptide binding]; other site 1117943015307 putative active site [active] 1117943015308 Uncharacterized conserved protein [Function unknown]; Region: COG5476 1117943015309 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 1117943015310 MlrC C-terminus; Region: MlrC_C; pfam07171 1117943015311 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1117943015312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943015313 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1117943015314 dimerization interface [polypeptide binding]; other site 1117943015315 substrate binding pocket [chemical binding]; other site 1117943015316 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1117943015317 homotrimer interaction site [polypeptide binding]; other site 1117943015318 putative active site [active] 1117943015319 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1117943015320 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1117943015321 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1117943015322 catalytic residue [active] 1117943015323 short chain dehydrogenase; Provisional; Region: PRK08339 1117943015324 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1117943015325 putative NAD(P) binding site [chemical binding]; other site 1117943015326 putative active site [active] 1117943015327 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1117943015328 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943015329 Coenzyme A binding pocket [chemical binding]; other site 1117943015330 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1117943015331 putative dimer interface [polypeptide binding]; other site 1117943015332 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943015333 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 1117943015334 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943015335 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1117943015336 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1117943015337 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943015338 Walker A/P-loop; other site 1117943015339 ATP binding site [chemical binding]; other site 1117943015340 Q-loop/lid; other site 1117943015341 ABC transporter signature motif; other site 1117943015342 Walker B; other site 1117943015343 D-loop; other site 1117943015344 H-loop/switch region; other site 1117943015345 TOBE domain; Region: TOBE_2; pfam08402 1117943015346 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943015347 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1117943015348 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943015349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943015350 dimer interface [polypeptide binding]; other site 1117943015351 conserved gate region; other site 1117943015352 putative PBP binding loops; other site 1117943015353 ABC-ATPase subunit interface; other site 1117943015354 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1117943015355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943015356 dimer interface [polypeptide binding]; other site 1117943015357 conserved gate region; other site 1117943015358 putative PBP binding loops; other site 1117943015359 ABC-ATPase subunit interface; other site 1117943015360 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943015361 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943015362 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1117943015363 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1117943015364 active site 1117943015365 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1117943015366 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1117943015367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943015368 dimer interface [polypeptide binding]; other site 1117943015369 conserved gate region; other site 1117943015370 putative PBP binding loops; other site 1117943015371 ABC-ATPase subunit interface; other site 1117943015372 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1117943015373 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1117943015374 Walker A/P-loop; other site 1117943015375 ATP binding site [chemical binding]; other site 1117943015376 Q-loop/lid; other site 1117943015377 ABC transporter signature motif; other site 1117943015378 Walker B; other site 1117943015379 D-loop; other site 1117943015380 H-loop/switch region; other site 1117943015381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943015382 dimer interface [polypeptide binding]; other site 1117943015383 conserved gate region; other site 1117943015384 ABC-ATPase subunit interface; other site 1117943015385 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1117943015386 Predicted membrane protein [Function unknown]; Region: COG3918 1117943015387 mercuric reductase; Validated; Region: PRK06370 1117943015388 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1117943015389 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1117943015390 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1117943015391 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1117943015392 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1117943015393 Amidinotransferase; Region: Amidinotransf; cl12043 1117943015394 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1117943015395 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1117943015396 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943015397 Walker A/P-loop; other site 1117943015398 ATP binding site [chemical binding]; other site 1117943015399 Q-loop/lid; other site 1117943015400 ABC transporter signature motif; other site 1117943015401 Walker B; other site 1117943015402 D-loop; other site 1117943015403 H-loop/switch region; other site 1117943015404 TOBE domain; Region: TOBE_2; pfam08402 1117943015405 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943015406 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943015407 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943015408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1117943015409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943015410 dimer interface [polypeptide binding]; other site 1117943015411 conserved gate region; other site 1117943015412 putative PBP binding loops; other site 1117943015413 ABC-ATPase subunit interface; other site 1117943015414 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1117943015415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943015416 dimer interface [polypeptide binding]; other site 1117943015417 conserved gate region; other site 1117943015418 putative PBP binding loops; other site 1117943015419 ABC-ATPase subunit interface; other site 1117943015420 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1117943015421 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1117943015422 substrate binding site [chemical binding]; other site 1117943015423 dimer interface [polypeptide binding]; other site 1117943015424 ATP binding site [chemical binding]; other site 1117943015425 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 1117943015426 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1117943015427 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1117943015428 NAD(P) binding site [chemical binding]; other site 1117943015429 catalytic residues [active] 1117943015430 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1117943015431 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1117943015432 NAD(P) binding site [chemical binding]; other site 1117943015433 catalytic residues [active] 1117943015434 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1117943015435 intersubunit interface [polypeptide binding]; other site 1117943015436 active site 1117943015437 catalytic residue [active] 1117943015438 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1117943015439 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1117943015440 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1117943015441 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943015442 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943015443 DNA-binding site [nucleotide binding]; DNA binding site 1117943015444 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1117943015445 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1117943015446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943015447 Walker A/P-loop; other site 1117943015448 ATP binding site [chemical binding]; other site 1117943015449 Q-loop/lid; other site 1117943015450 ABC transporter signature motif; other site 1117943015451 Walker B; other site 1117943015452 D-loop; other site 1117943015453 H-loop/switch region; other site 1117943015454 TOBE domain; Region: TOBE_2; pfam08402 1117943015455 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1117943015456 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1117943015457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943015458 dimer interface [polypeptide binding]; other site 1117943015459 conserved gate region; other site 1117943015460 putative PBP binding loops; other site 1117943015461 ABC-ATPase subunit interface; other site 1117943015462 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1117943015463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943015464 dimer interface [polypeptide binding]; other site 1117943015465 conserved gate region; other site 1117943015466 putative PBP binding loops; other site 1117943015467 ABC-ATPase subunit interface; other site 1117943015468 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1117943015469 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 1117943015470 putative binding site; other site 1117943015471 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1117943015472 MG2 domain; Region: A2M_N; pfam01835 1117943015473 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1117943015474 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1117943015475 surface patch; other site 1117943015476 thioester region; other site 1117943015477 specificity defining residues; other site 1117943015478 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 1117943015479 Transglycosylase; Region: Transgly; pfam00912 1117943015480 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1117943015481 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1117943015482 guanine deaminase; Provisional; Region: PRK09228 1117943015483 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1117943015484 active site 1117943015485 Predicted membrane protein [Function unknown]; Region: COG3748 1117943015486 Protein of unknown function (DUF989); Region: DUF989; pfam06181 1117943015487 Cytochrome c; Region: Cytochrom_C; pfam00034 1117943015488 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943015489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943015490 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1117943015491 putative effector binding pocket; other site 1117943015492 dimerization interface [polypeptide binding]; other site 1117943015493 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1117943015494 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1117943015495 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1117943015496 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 1117943015497 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1117943015498 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1117943015499 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 1117943015500 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1117943015501 catalytic loop [active] 1117943015502 iron binding site [ion binding]; other site 1117943015503 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1117943015504 FAD binding domain; Region: FAD_binding_4; pfam01565 1117943015505 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1117943015506 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1117943015507 active site 1117943015508 homotetramer interface [polypeptide binding]; other site 1117943015509 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1117943015510 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1117943015511 active site 1117943015512 catalytic site [active] 1117943015513 tetramer interface [polypeptide binding]; other site 1117943015514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 1117943015515 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1117943015516 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1117943015517 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1117943015518 Walker A/P-loop; other site 1117943015519 ATP binding site [chemical binding]; other site 1117943015520 Q-loop/lid; other site 1117943015521 ABC transporter signature motif; other site 1117943015522 Walker B; other site 1117943015523 D-loop; other site 1117943015524 H-loop/switch region; other site 1117943015525 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1117943015526 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1117943015527 Walker A/P-loop; other site 1117943015528 ATP binding site [chemical binding]; other site 1117943015529 Q-loop/lid; other site 1117943015530 ABC transporter signature motif; other site 1117943015531 Walker B; other site 1117943015532 D-loop; other site 1117943015533 H-loop/switch region; other site 1117943015534 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943015535 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1117943015536 TM-ABC transporter signature motif; other site 1117943015537 Transposase domain (DUF772); Region: DUF772; pfam05598 1117943015538 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943015539 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1117943015540 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943015541 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1117943015542 TM-ABC transporter signature motif; other site 1117943015543 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1117943015544 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1117943015545 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1117943015546 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1117943015547 Cupin domain; Region: Cupin_2; cl17218 1117943015548 Helix-turn-helix domain; Region: HTH_18; pfam12833 1117943015549 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943015550 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1117943015551 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1117943015552 dimer interface [polypeptide binding]; other site 1117943015553 active site 1117943015554 heme binding site [chemical binding]; other site 1117943015555 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1117943015556 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1117943015557 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943015558 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1117943015559 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1117943015560 [2Fe-2S] cluster binding site [ion binding]; other site 1117943015561 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1117943015562 putative catalytic residues [active] 1117943015563 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1117943015564 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943015565 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943015566 dimerization interface [polypeptide binding]; other site 1117943015567 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1117943015568 tetramerization interface [polypeptide binding]; other site 1117943015569 active site 1117943015570 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1117943015571 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1117943015572 active site 1117943015573 phosphorylation site [posttranslational modification] 1117943015574 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1117943015575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943015576 active site 1117943015577 phosphorylation site [posttranslational modification] 1117943015578 intermolecular recognition site; other site 1117943015579 dimerization interface [polypeptide binding]; other site 1117943015580 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943015581 DNA binding site [nucleotide binding] 1117943015582 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1117943015583 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1117943015584 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1117943015585 Ligand Binding Site [chemical binding]; other site 1117943015586 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1117943015587 GAF domain; Region: GAF_3; pfam13492 1117943015588 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943015589 dimer interface [polypeptide binding]; other site 1117943015590 phosphorylation site [posttranslational modification] 1117943015591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943015592 ATP binding site [chemical binding]; other site 1117943015593 Mg2+ binding site [ion binding]; other site 1117943015594 G-X-G motif; other site 1117943015595 potassium-transporting ATPase subunit C; Provisional; Region: PRK13999 1117943015596 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1117943015597 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943015598 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1117943015599 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1117943015600 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1117943015601 potassium-transporting ATPase subunit F; Provisional; Region: PRK14759 1117943015602 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 1117943015603 putative hydrophobic ligand binding site [chemical binding]; other site 1117943015604 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1117943015605 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1117943015606 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1117943015607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943015608 NAD(P) binding site [chemical binding]; other site 1117943015609 active site 1117943015610 short chain dehydrogenase; Provisional; Region: PRK06114 1117943015611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943015612 NAD(P) binding site [chemical binding]; other site 1117943015613 active site 1117943015614 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1117943015615 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1117943015616 Walker A/P-loop; other site 1117943015617 ATP binding site [chemical binding]; other site 1117943015618 Q-loop/lid; other site 1117943015619 ABC transporter signature motif; other site 1117943015620 Walker B; other site 1117943015621 D-loop; other site 1117943015622 H-loop/switch region; other site 1117943015623 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1117943015624 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1117943015625 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1117943015626 ligand binding site [chemical binding]; other site 1117943015627 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943015628 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943015629 TM-ABC transporter signature motif; other site 1117943015630 transketolase; Reviewed; Region: PRK05899 1117943015631 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1117943015632 TPP-binding site [chemical binding]; other site 1117943015633 dimer interface [polypeptide binding]; other site 1117943015634 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1117943015635 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1117943015636 PYR/PP interface [polypeptide binding]; other site 1117943015637 dimer interface [polypeptide binding]; other site 1117943015638 TPP binding site [chemical binding]; other site 1117943015639 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1117943015640 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1117943015641 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 1117943015642 N- and C-terminal domain interface [polypeptide binding]; other site 1117943015643 active site 1117943015644 MgATP binding site [chemical binding]; other site 1117943015645 catalytic site [active] 1117943015646 metal binding site [ion binding]; metal-binding site 1117943015647 putative homotetramer interface [polypeptide binding]; other site 1117943015648 putative homodimer interface [polypeptide binding]; other site 1117943015649 glycerol binding site [chemical binding]; other site 1117943015650 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1117943015651 MarR family; Region: MarR_2; cl17246 1117943015652 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1117943015653 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1117943015654 metal-binding site [ion binding] 1117943015655 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1117943015656 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1117943015657 metal-binding site [ion binding] 1117943015658 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943015659 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943015660 motif II; other site 1117943015661 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1117943015662 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1117943015663 DNA binding residues [nucleotide binding] 1117943015664 dimer interface [polypeptide binding]; other site 1117943015665 copper binding site [ion binding]; other site 1117943015666 Predicted metal-binding protein [General function prediction only]; Region: COG3019 1117943015667 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1117943015668 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1117943015669 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1117943015670 ligand binding site [chemical binding]; other site 1117943015671 flexible hinge region; other site 1117943015672 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1117943015673 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1117943015674 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943015675 Walker A/P-loop; other site 1117943015676 ATP binding site [chemical binding]; other site 1117943015677 Q-loop/lid; other site 1117943015678 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1117943015679 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943015680 ABC transporter signature motif; other site 1117943015681 Walker B; other site 1117943015682 D-loop; other site 1117943015683 H-loop/switch region; other site 1117943015684 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1117943015685 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1117943015686 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1117943015687 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1117943015688 putative ADP-binding pocket [chemical binding]; other site 1117943015689 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1117943015690 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1117943015691 microcin C ABC transporter permease; Provisional; Region: PRK15021 1117943015692 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1117943015693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943015694 dimer interface [polypeptide binding]; other site 1117943015695 conserved gate region; other site 1117943015696 putative PBP binding loops; other site 1117943015697 ABC-ATPase subunit interface; other site 1117943015698 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1117943015699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943015700 putative PBP binding loops; other site 1117943015701 dimer interface [polypeptide binding]; other site 1117943015702 ABC-ATPase subunit interface; other site 1117943015703 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 1117943015704 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1117943015705 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1117943015706 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943015707 Walker A/P-loop; other site 1117943015708 ATP binding site [chemical binding]; other site 1117943015709 Q-loop/lid; other site 1117943015710 ABC transporter signature motif; other site 1117943015711 Walker B; other site 1117943015712 D-loop; other site 1117943015713 H-loop/switch region; other site 1117943015714 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1117943015715 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943015716 Walker A/P-loop; other site 1117943015717 ATP binding site [chemical binding]; other site 1117943015718 Q-loop/lid; other site 1117943015719 ABC transporter signature motif; other site 1117943015720 Walker B; other site 1117943015721 D-loop; other site 1117943015722 H-loop/switch region; other site 1117943015723 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1117943015724 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 1117943015725 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943015726 cyclase homology domain; Region: CHD; cd07302 1117943015727 nucleotidyl binding site; other site 1117943015728 metal binding site [ion binding]; metal-binding site 1117943015729 dimer interface [polypeptide binding]; other site 1117943015730 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1117943015731 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1117943015732 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1117943015733 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1117943015734 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 1117943015735 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1117943015736 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 1117943015737 NodB motif; other site 1117943015738 putative active site [active] 1117943015739 putative catalytic site [active] 1117943015740 putative Zn binding site [ion binding]; other site 1117943015741 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1117943015742 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1117943015743 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1117943015744 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1117943015745 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1117943015746 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1117943015747 putative ADP-binding pocket [chemical binding]; other site 1117943015748 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1117943015749 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1117943015750 inhibitor-cofactor binding pocket; inhibition site 1117943015751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943015752 catalytic residue [active] 1117943015753 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1117943015754 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1117943015755 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1117943015756 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1117943015757 SLBB domain; Region: SLBB; pfam10531 1117943015758 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1117943015759 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1117943015760 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1117943015761 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1117943015762 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1117943015763 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1117943015764 Chain length determinant protein; Region: Wzz; pfam02706 1117943015765 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1117943015766 methionyl-tRNA formyltransferase; Region: fmt; TIGR00460 1117943015767 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_4; cd08651 1117943015768 putative active site [active] 1117943015769 putative substrate binding site [chemical binding]; other site 1117943015770 putative cosubstrate binding site; other site 1117943015771 catalytic site [active] 1117943015772 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1117943015773 active site 1117943015774 hexamer interface [polypeptide binding]; other site 1117943015775 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1117943015776 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1117943015777 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1117943015778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943015779 active site 1117943015780 phosphorylation site [posttranslational modification] 1117943015781 intermolecular recognition site; other site 1117943015782 dimerization interface [polypeptide binding]; other site 1117943015783 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943015784 DNA binding residues [nucleotide binding] 1117943015785 dimerization interface [polypeptide binding]; other site 1117943015786 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1117943015787 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1117943015788 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1117943015789 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943015790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943015791 DNA-binding site [nucleotide binding]; DNA binding site 1117943015792 FCD domain; Region: FCD; pfam07729 1117943015793 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 1117943015794 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1117943015795 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1117943015796 Walker A/P-loop; other site 1117943015797 ATP binding site [chemical binding]; other site 1117943015798 Q-loop/lid; other site 1117943015799 ABC transporter signature motif; other site 1117943015800 Walker B; other site 1117943015801 D-loop; other site 1117943015802 H-loop/switch region; other site 1117943015803 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1117943015804 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1117943015805 Walker A/P-loop; other site 1117943015806 ATP binding site [chemical binding]; other site 1117943015807 Q-loop/lid; other site 1117943015808 ABC transporter signature motif; other site 1117943015809 Walker B; other site 1117943015810 D-loop; other site 1117943015811 H-loop/switch region; other site 1117943015812 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943015813 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1117943015814 TM-ABC transporter signature motif; other site 1117943015815 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943015816 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1117943015817 TM-ABC transporter signature motif; other site 1117943015818 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1117943015819 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1117943015820 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1117943015821 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1117943015822 FeS/SAM binding site; other site 1117943015823 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1117943015824 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 1117943015825 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1117943015826 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1117943015827 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1117943015828 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 1117943015829 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943015830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943015831 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1117943015832 putative dimerization interface [polypeptide binding]; other site 1117943015833 fructose-1,6-bisphosphatase family protein; Region: PLN02628 1117943015834 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1117943015835 AMP binding site [chemical binding]; other site 1117943015836 metal binding site [ion binding]; metal-binding site 1117943015837 active site 1117943015838 phosphoribulokinase; Provisional; Region: PRK15453 1117943015839 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1117943015840 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1117943015841 TPP-binding site [chemical binding]; other site 1117943015842 dimer interface [polypeptide binding]; other site 1117943015843 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1117943015844 PYR/PP interface [polypeptide binding]; other site 1117943015845 dimer interface [polypeptide binding]; other site 1117943015846 TPP binding site [chemical binding]; other site 1117943015847 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1117943015848 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1117943015849 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1117943015850 intersubunit interface [polypeptide binding]; other site 1117943015851 active site 1117943015852 zinc binding site [ion binding]; other site 1117943015853 Na+ binding site [ion binding]; other site 1117943015854 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 1117943015855 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 1117943015856 homodimer interface [polypeptide binding]; other site 1117943015857 active site 1117943015858 heterodimer interface [polypeptide binding]; other site 1117943015859 catalytic residue [active] 1117943015860 metal binding site [ion binding]; metal-binding site 1117943015861 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 1117943015862 multimerization interface [polypeptide binding]; other site 1117943015863 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 1117943015864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943015865 Walker A motif; other site 1117943015866 ATP binding site [chemical binding]; other site 1117943015867 Walker B motif; other site 1117943015868 arginine finger; other site 1117943015869 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1117943015870 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1117943015871 substrate binding site [chemical binding]; other site 1117943015872 hexamer interface [polypeptide binding]; other site 1117943015873 metal binding site [ion binding]; metal-binding site 1117943015874 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1117943015875 putative catalytic residue [active] 1117943015876 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 1117943015877 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1117943015878 alcohol ABC transporter, permease protein; Region: phenyl_ABC_PedC; TIGR03861 1117943015879 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1117943015880 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1117943015881 Walker A/P-loop; other site 1117943015882 ATP binding site [chemical binding]; other site 1117943015883 Q-loop/lid; other site 1117943015884 ABC transporter signature motif; other site 1117943015885 Walker B; other site 1117943015886 D-loop; other site 1117943015887 H-loop/switch region; other site 1117943015888 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943015889 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1117943015890 Walker A/P-loop; other site 1117943015891 ATP binding site [chemical binding]; other site 1117943015892 Q-loop/lid; other site 1117943015893 ABC transporter signature motif; other site 1117943015894 Walker B; other site 1117943015895 D-loop; other site 1117943015896 H-loop/switch region; other site 1117943015897 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1117943015898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943015899 dimer interface [polypeptide binding]; other site 1117943015900 conserved gate region; other site 1117943015901 putative PBP binding loops; other site 1117943015902 ABC-ATPase subunit interface; other site 1117943015903 NMT1/THI5 like; Region: NMT1; pfam09084 1117943015904 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1117943015905 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1117943015906 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1117943015907 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1117943015908 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1117943015909 ligand binding site [chemical binding]; other site 1117943015910 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 1117943015911 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1117943015912 putative hydrophobic ligand binding site [chemical binding]; other site 1117943015913 protein interface [polypeptide binding]; other site 1117943015914 gate; other site 1117943015915 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1117943015916 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1117943015917 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1117943015918 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1117943015919 active site residue [active] 1117943015920 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 1117943015921 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943015922 substrate binding pocket [chemical binding]; other site 1117943015923 membrane-bound complex binding site; other site 1117943015924 hinge residues; other site 1117943015925 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 1117943015926 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1117943015927 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1117943015928 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 1117943015929 Trp docking motif [polypeptide binding]; other site 1117943015930 dimer interface [polypeptide binding]; other site 1117943015931 active site 1117943015932 small subunit binding site [polypeptide binding]; other site 1117943015933 Cytochrome c2 [Energy production and conversion]; Region: COG3474 1117943015934 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1117943015935 S-formylglutathione hydrolase; Region: PLN02442 1117943015936 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1117943015937 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1117943015938 substrate binding site [chemical binding]; other site 1117943015939 catalytic Zn binding site [ion binding]; other site 1117943015940 NAD binding site [chemical binding]; other site 1117943015941 structural Zn binding site [ion binding]; other site 1117943015942 dimer interface [polypeptide binding]; other site 1117943015943 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1117943015944 Predicted secreted protein [Function unknown]; Region: COG5501 1117943015945 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943015946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943015947 dimer interface [polypeptide binding]; other site 1117943015948 phosphorylation site [posttranslational modification] 1117943015949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943015950 ATP binding site [chemical binding]; other site 1117943015951 Mg2+ binding site [ion binding]; other site 1117943015952 G-X-G motif; other site 1117943015953 Response regulator receiver domain; Region: Response_reg; pfam00072 1117943015954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943015955 active site 1117943015956 phosphorylation site [posttranslational modification] 1117943015957 intermolecular recognition site; other site 1117943015958 dimerization interface [polypeptide binding]; other site 1117943015959 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1117943015960 FIST N domain; Region: FIST; pfam08495 1117943015961 FIST C domain; Region: FIST_C; pfam10442 1117943015962 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1117943015963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943015964 active site 1117943015965 phosphorylation site [posttranslational modification] 1117943015966 intermolecular recognition site; other site 1117943015967 dimerization interface [polypeptide binding]; other site 1117943015968 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943015969 DNA binding residues [nucleotide binding] 1117943015970 dimerization interface [polypeptide binding]; other site 1117943015971 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1117943015972 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1117943015973 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1117943015974 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1117943015975 DNA binding residues [nucleotide binding] 1117943015976 Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561 1117943015977 active site 1117943015978 catalytic triad [active] 1117943015979 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1117943015980 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1117943015981 active site 1117943015982 nucleophile elbow; other site 1117943015983 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1117943015984 putative active site [active] 1117943015985 Predicted transcriptional regulator [Transcription]; Region: COG1959 1117943015986 Transcriptional regulator; Region: Rrf2; pfam02082 1117943015987 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1117943015988 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1117943015989 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1117943015990 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1117943015991 SelR domain; Region: SelR; pfam01641 1117943015992 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1117943015993 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1117943015994 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1117943015995 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1117943015996 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1117943015997 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1117943015998 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1117943015999 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1117943016000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943016001 active site 1117943016002 phosphorylation site [posttranslational modification] 1117943016003 intermolecular recognition site; other site 1117943016004 dimerization interface [polypeptide binding]; other site 1117943016005 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943016006 DNA binding site [nucleotide binding] 1117943016007 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1117943016008 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943016009 dimerization interface [polypeptide binding]; other site 1117943016010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943016011 dimer interface [polypeptide binding]; other site 1117943016012 phosphorylation site [posttranslational modification] 1117943016013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943016014 ATP binding site [chemical binding]; other site 1117943016015 Mg2+ binding site [ion binding]; other site 1117943016016 G-X-G motif; other site 1117943016017 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1117943016018 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943016019 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1117943016020 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1117943016021 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1117943016022 conserved cys residue [active] 1117943016023 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943016024 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1117943016025 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1117943016026 classical (c) SDRs; Region: SDR_c; cd05233 1117943016027 NAD(P) binding site [chemical binding]; other site 1117943016028 active site 1117943016029 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1117943016030 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1117943016031 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1117943016032 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1117943016033 catalytic residues [active] 1117943016034 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943016035 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943016036 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 1117943016037 putative effector binding pocket; other site 1117943016038 putative dimerization interface [polypeptide binding]; other site 1117943016039 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1117943016040 classical (c) SDRs; Region: SDR_c; cd05233 1117943016041 NAD(P) binding site [chemical binding]; other site 1117943016042 active site 1117943016043 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1117943016044 active site 1 [active] 1117943016045 dimer interface [polypeptide binding]; other site 1117943016046 hexamer interface [polypeptide binding]; other site 1117943016047 active site 2 [active] 1117943016048 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1117943016049 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943016050 cyclase homology domain; Region: CHD; cd07302 1117943016051 nucleotidyl binding site; other site 1117943016052 metal binding site [ion binding]; metal-binding site 1117943016053 dimer interface [polypeptide binding]; other site 1117943016054 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943016055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943016056 binding surface 1117943016057 TPR motif; other site 1117943016058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943016059 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1117943016060 TPR motif; other site 1117943016061 binding surface 1117943016062 PAS fold; Region: PAS_7; pfam12860 1117943016063 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943016064 putative active site [active] 1117943016065 heme pocket [chemical binding]; other site 1117943016066 PAS fold; Region: PAS_7; pfam12860 1117943016067 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943016068 dimer interface [polypeptide binding]; other site 1117943016069 phosphorylation site [posttranslational modification] 1117943016070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943016071 ATP binding site [chemical binding]; other site 1117943016072 Mg2+ binding site [ion binding]; other site 1117943016073 G-X-G motif; other site 1117943016074 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1117943016075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943016076 active site 1117943016077 phosphorylation site [posttranslational modification] 1117943016078 intermolecular recognition site; other site 1117943016079 dimerization interface [polypeptide binding]; other site 1117943016080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943016081 Response regulator receiver domain; Region: Response_reg; pfam00072 1117943016082 active site 1117943016083 phosphorylation site [posttranslational modification] 1117943016084 intermolecular recognition site; other site 1117943016085 dimerization interface [polypeptide binding]; other site 1117943016086 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1117943016087 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1117943016088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943016089 active site 1117943016090 phosphorylation site [posttranslational modification] 1117943016091 intermolecular recognition site; other site 1117943016092 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1117943016093 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1117943016094 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1117943016095 NAD(P) binding site [chemical binding]; other site 1117943016096 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1117943016097 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1117943016098 NAD(P) binding site [chemical binding]; other site 1117943016099 homodimer interface [polypeptide binding]; other site 1117943016100 substrate binding site [chemical binding]; other site 1117943016101 active site 1117943016102 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1117943016103 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1117943016104 putative ADP-binding pocket [chemical binding]; other site 1117943016105 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1117943016106 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 1117943016107 putative ADP-binding pocket [chemical binding]; other site 1117943016108 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1117943016109 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1117943016110 extended (e) SDRs; Region: SDR_e; cd08946 1117943016111 NAD(P) binding site [chemical binding]; other site 1117943016112 active site 1117943016113 substrate binding site [chemical binding]; other site 1117943016114 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 1117943016115 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1117943016116 PHP domain; Region: PHP; pfam02811 1117943016117 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1117943016118 active site 1117943016119 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1117943016120 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1117943016121 active site 1117943016122 dimer interface [polypeptide binding]; other site 1117943016123 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1117943016124 Ligand Binding Site [chemical binding]; other site 1117943016125 Molecular Tunnel; other site 1117943016126 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1117943016127 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1117943016128 active site 1117943016129 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1117943016130 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1117943016131 CysD dimerization site [polypeptide binding]; other site 1117943016132 G1 box; other site 1117943016133 putative GEF interaction site [polypeptide binding]; other site 1117943016134 GTP/Mg2+ binding site [chemical binding]; other site 1117943016135 Switch I region; other site 1117943016136 G2 box; other site 1117943016137 G3 box; other site 1117943016138 Switch II region; other site 1117943016139 G4 box; other site 1117943016140 G5 box; other site 1117943016141 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1117943016142 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1117943016143 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1117943016144 ligand-binding site [chemical binding]; other site 1117943016145 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1117943016146 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1117943016147 Active Sites [active] 1117943016148 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1117943016149 non-specific DNA interactions [nucleotide binding]; other site 1117943016150 DNA binding site [nucleotide binding] 1117943016151 sequence specific DNA binding site [nucleotide binding]; other site 1117943016152 putative cAMP binding site [chemical binding]; other site 1117943016153 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1117943016154 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1117943016155 nucleotide binding site [chemical binding]; other site 1117943016156 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943016157 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943016158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943016159 dimer interface [polypeptide binding]; other site 1117943016160 conserved gate region; other site 1117943016161 putative PBP binding loops; other site 1117943016162 ABC-ATPase subunit interface; other site 1117943016163 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943016164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943016165 dimer interface [polypeptide binding]; other site 1117943016166 conserved gate region; other site 1117943016167 putative PBP binding loops; other site 1117943016168 ABC-ATPase subunit interface; other site 1117943016169 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1117943016170 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1117943016171 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1117943016172 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1117943016173 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943016174 Walker A/P-loop; other site 1117943016175 ATP binding site [chemical binding]; other site 1117943016176 Q-loop/lid; other site 1117943016177 ABC transporter signature motif; other site 1117943016178 Walker B; other site 1117943016179 D-loop; other site 1117943016180 H-loop/switch region; other site 1117943016181 TOBE domain; Region: TOBE_2; pfam08402 1117943016182 indole acetimide hydrolase; Validated; Region: PRK07488 1117943016183 Amidase; Region: Amidase; pfam01425 1117943016184 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1117943016185 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1117943016186 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1117943016187 homotrimer interaction site [polypeptide binding]; other site 1117943016188 putative active site [active] 1117943016189 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1117943016190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943016191 Walker A/P-loop; other site 1117943016192 ATP binding site [chemical binding]; other site 1117943016193 Q-loop/lid; other site 1117943016194 ABC transporter signature motif; other site 1117943016195 Walker B; other site 1117943016196 D-loop; other site 1117943016197 H-loop/switch region; other site 1117943016198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943016199 dimer interface [polypeptide binding]; other site 1117943016200 conserved gate region; other site 1117943016201 putative PBP binding loops; other site 1117943016202 ABC-ATPase subunit interface; other site 1117943016203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943016204 dimer interface [polypeptide binding]; other site 1117943016205 conserved gate region; other site 1117943016206 putative PBP binding loops; other site 1117943016207 ABC-ATPase subunit interface; other site 1117943016208 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1117943016209 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943016210 substrate binding pocket [chemical binding]; other site 1117943016211 membrane-bound complex binding site; other site 1117943016212 hinge residues; other site 1117943016213 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1117943016214 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 1117943016215 dimer interface [polypeptide binding]; other site 1117943016216 active site 1117943016217 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1117943016218 substrate binding site [chemical binding]; other site 1117943016219 catalytic residue [active] 1117943016220 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1117943016221 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943016222 substrate binding pocket [chemical binding]; other site 1117943016223 membrane-bound complex binding site; other site 1117943016224 hinge residues; other site 1117943016225 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1117943016226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943016227 dimer interface [polypeptide binding]; other site 1117943016228 conserved gate region; other site 1117943016229 putative PBP binding loops; other site 1117943016230 ABC-ATPase subunit interface; other site 1117943016231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943016232 dimer interface [polypeptide binding]; other site 1117943016233 conserved gate region; other site 1117943016234 putative PBP binding loops; other site 1117943016235 ABC-ATPase subunit interface; other site 1117943016236 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1117943016237 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1117943016238 Walker A/P-loop; other site 1117943016239 ATP binding site [chemical binding]; other site 1117943016240 Q-loop/lid; other site 1117943016241 ABC transporter signature motif; other site 1117943016242 Walker B; other site 1117943016243 D-loop; other site 1117943016244 H-loop/switch region; other site 1117943016245 TOBE-like domain; Region: TOBE_3; pfam12857 1117943016246 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1117943016247 FAD binding domain; Region: FAD_binding_4; pfam01565 1117943016248 Uncharacterized conserved protein [Function unknown]; Region: COG5654 1117943016249 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1117943016250 enoyl-CoA hydratase; Provisional; Region: PRK07468 1117943016251 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1117943016252 substrate binding site [chemical binding]; other site 1117943016253 oxyanion hole (OAH) forming residues; other site 1117943016254 trimer interface [polypeptide binding]; other site 1117943016255 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1117943016256 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1117943016257 active site 1117943016258 catalytic residues [active] 1117943016259 metal binding site [ion binding]; metal-binding site 1117943016260 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1117943016261 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1117943016262 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1117943016263 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1117943016264 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1117943016265 carboxyltransferase (CT) interaction site; other site 1117943016266 biotinylation site [posttranslational modification]; other site 1117943016267 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1117943016268 homotrimer interaction site [polypeptide binding]; other site 1117943016269 putative active site [active] 1117943016270 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1117943016271 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1117943016272 isovaleryl-CoA dehydrogenase; Region: PLN02519 1117943016273 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1117943016274 substrate binding site [chemical binding]; other site 1117943016275 FAD binding site [chemical binding]; other site 1117943016276 catalytic base [active] 1117943016277 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1117943016278 intersubunit interface [polypeptide binding]; other site 1117943016279 active site 1117943016280 Zn2+ binding site [ion binding]; other site 1117943016281 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1117943016282 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 1117943016283 N- and C-terminal domain interface [polypeptide binding]; other site 1117943016284 putative active site [active] 1117943016285 putative MgATP binding site [chemical binding]; other site 1117943016286 putative catalytic site [active] 1117943016287 metal binding site [ion binding]; metal-binding site 1117943016288 putative carbohydrate binding site [chemical binding]; other site 1117943016289 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1117943016290 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1117943016291 DNA interaction; other site 1117943016292 Metal-binding active site; metal-binding site 1117943016293 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943016294 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943016295 TM-ABC transporter signature motif; other site 1117943016296 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943016297 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943016298 TM-ABC transporter signature motif; other site 1117943016299 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1117943016300 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1117943016301 Walker A/P-loop; other site 1117943016302 ATP binding site [chemical binding]; other site 1117943016303 Q-loop/lid; other site 1117943016304 ABC transporter signature motif; other site 1117943016305 Walker B; other site 1117943016306 D-loop; other site 1117943016307 H-loop/switch region; other site 1117943016308 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1117943016309 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1117943016310 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1117943016311 ligand binding site [chemical binding]; other site 1117943016312 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1117943016313 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1117943016314 dimerization interface [polypeptide binding]; other site 1117943016315 ligand binding site [chemical binding]; other site 1117943016316 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943016317 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943016318 dimerization interface [polypeptide binding]; other site 1117943016319 putative DNA binding site [nucleotide binding]; other site 1117943016320 putative Zn2+ binding site [ion binding]; other site 1117943016321 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943016322 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943016323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943016324 non-specific DNA binding site [nucleotide binding]; other site 1117943016325 salt bridge; other site 1117943016326 sequence-specific DNA binding site [nucleotide binding]; other site 1117943016327 Uncharacterized conserved protein [Function unknown]; Region: COG3482 1117943016328 PaaX-like protein; Region: PaaX; pfam07848 1117943016329 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1117943016330 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1117943016331 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943016332 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1117943016333 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943016334 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1117943016335 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1117943016336 tetramer interface [polypeptide binding]; other site 1117943016337 TPP-binding site [chemical binding]; other site 1117943016338 heterodimer interface [polypeptide binding]; other site 1117943016339 phosphorylation loop region [posttranslational modification] 1117943016340 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1117943016341 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1117943016342 alpha subunit interface [polypeptide binding]; other site 1117943016343 TPP binding site [chemical binding]; other site 1117943016344 heterodimer interface [polypeptide binding]; other site 1117943016345 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1117943016346 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 1117943016347 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1117943016348 E3 interaction surface; other site 1117943016349 lipoyl attachment site [posttranslational modification]; other site 1117943016350 e3 binding domain; Region: E3_binding; pfam02817 1117943016351 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1117943016352 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1117943016353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943016354 active site 1117943016355 phosphorylation site [posttranslational modification] 1117943016356 intermolecular recognition site; other site 1117943016357 ANTAR domain; Region: ANTAR; pfam03861 1117943016358 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1117943016359 NMT1-like family; Region: NMT1_2; pfam13379 1117943016360 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1117943016361 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1117943016362 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1117943016363 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1117943016364 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1117943016365 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1117943016366 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1117943016367 [2Fe-2S] cluster binding site [ion binding]; other site 1117943016368 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1117943016369 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1117943016370 [4Fe-4S] binding site [ion binding]; other site 1117943016371 molybdopterin cofactor binding site; other site 1117943016372 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1117943016373 molybdopterin cofactor binding site; other site 1117943016374 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1117943016375 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 1117943016376 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1117943016377 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1117943016378 Uroporphyrinogen-III methylase [Coenzyme metabolism]; Region: CysG; COG0007 1117943016379 homodimer interface [polypeptide binding]; other site 1117943016380 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1117943016381 nudix motif; other site 1117943016382 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 1117943016383 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1117943016384 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1117943016385 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1117943016386 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 1117943016387 dimer interface [polypeptide binding]; other site 1117943016388 active site residues [active] 1117943016389 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1117943016390 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1117943016391 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943016392 DNA binding site [nucleotide binding] 1117943016393 domain linker motif; other site 1117943016394 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1117943016395 putative dimerization interface [polypeptide binding]; other site 1117943016396 putative ligand binding site [chemical binding]; other site 1117943016397 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943016398 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943016399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943016400 dimer interface [polypeptide binding]; other site 1117943016401 conserved gate region; other site 1117943016402 putative PBP binding loops; other site 1117943016403 ABC-ATPase subunit interface; other site 1117943016404 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943016405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943016406 dimer interface [polypeptide binding]; other site 1117943016407 conserved gate region; other site 1117943016408 putative PBP binding loops; other site 1117943016409 ABC-ATPase subunit interface; other site 1117943016410 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1117943016411 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1117943016412 substrate binding [chemical binding]; other site 1117943016413 active site 1117943016414 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1117943016415 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1117943016416 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943016417 Walker A/P-loop; other site 1117943016418 ATP binding site [chemical binding]; other site 1117943016419 Q-loop/lid; other site 1117943016420 ABC transporter signature motif; other site 1117943016421 Walker B; other site 1117943016422 D-loop; other site 1117943016423 H-loop/switch region; other site 1117943016424 TOBE domain; Region: TOBE_2; pfam08402 1117943016425 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1117943016426 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1117943016427 Walker A/P-loop; other site 1117943016428 ATP binding site [chemical binding]; other site 1117943016429 Q-loop/lid; other site 1117943016430 ABC transporter signature motif; other site 1117943016431 Walker B; other site 1117943016432 D-loop; other site 1117943016433 H-loop/switch region; other site 1117943016434 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1117943016435 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1117943016436 ABC-ATPase subunit interface; other site 1117943016437 dimer interface [polypeptide binding]; other site 1117943016438 putative PBP binding regions; other site 1117943016439 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 1117943016440 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1117943016441 putative ligand binding residues [chemical binding]; other site 1117943016442 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1117943016443 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 1117943016444 putative ligand binding residues [chemical binding]; other site 1117943016445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943016446 S-adenosylmethionine binding site [chemical binding]; other site 1117943016447 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 1117943016448 FOG: CBS domain [General function prediction only]; Region: COG0517 1117943016449 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1117943016450 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1117943016451 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1117943016452 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1117943016453 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1117943016454 active site 1117943016455 catalytic site [active] 1117943016456 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1117943016457 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1117943016458 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1117943016459 catalytic site [active] 1117943016460 active site 1117943016461 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1117943016462 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1117943016463 Fe-S cluster binding site [ion binding]; other site 1117943016464 active site 1117943016465 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 1117943016466 glutathione s-transferase; Provisional; Region: PTZ00057 1117943016467 GSH binding site (G-site) [chemical binding]; other site 1117943016468 C-terminal domain interface [polypeptide binding]; other site 1117943016469 dimer interface [polypeptide binding]; other site 1117943016470 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 1117943016471 dimer interface [polypeptide binding]; other site 1117943016472 N-terminal domain interface [polypeptide binding]; other site 1117943016473 substrate binding pocket (H-site) [chemical binding]; other site 1117943016474 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 1117943016475 Protein of unknown function (DUF763); Region: DUF763; pfam05559 1117943016476 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1117943016477 active site 1117943016478 DNA binding site [nucleotide binding] 1117943016479 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1117943016480 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1117943016481 active site 1117943016482 DNA binding site [nucleotide binding] 1117943016483 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1117943016484 DNA binding site [nucleotide binding] 1117943016485 hydroperoxidase II; Provisional; Region: katE; PRK11249 1117943016486 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1117943016487 tetramer interface [polypeptide binding]; other site 1117943016488 heme binding pocket [chemical binding]; other site 1117943016489 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1117943016490 domain interactions; other site 1117943016491 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1117943016492 substrate binding site [chemical binding]; other site 1117943016493 glycogen synthase; Provisional; Region: glgA; PRK00654 1117943016494 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1117943016495 ADP-binding pocket [chemical binding]; other site 1117943016496 homodimer interface [polypeptide binding]; other site 1117943016497 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 1117943016498 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1117943016499 cyclase homology domain; Region: CHD; cd07302 1117943016500 nucleotidyl binding site; other site 1117943016501 metal binding site [ion binding]; metal-binding site 1117943016502 dimer interface [polypeptide binding]; other site 1117943016503 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1117943016504 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1117943016505 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1117943016506 DoxX; Region: DoxX; pfam07681 1117943016507 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 1117943016508 hypothetical protein; Provisional; Region: PRK05409 1117943016509 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 1117943016510 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943016511 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943016512 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1117943016513 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1117943016514 active site 1117943016515 nucleophile elbow; other site 1117943016516 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1117943016517 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943016518 NAD(P) binding site [chemical binding]; other site 1117943016519 active site 1117943016520 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943016521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943016522 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1117943016523 dimerization interface [polypeptide binding]; other site 1117943016524 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1117943016525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943016526 putative substrate translocation pore; other site 1117943016527 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1117943016528 Domain of unknown function DUF302; Region: DUF302; cl01364 1117943016529 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1117943016530 metal binding site [ion binding]; metal-binding site 1117943016531 Nitrate and nitrite sensing; Region: NIT; pfam08376 1117943016532 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1117943016533 dimerization interface [polypeptide binding]; other site 1117943016534 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1117943016535 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1117943016536 dimer interface [polypeptide binding]; other site 1117943016537 putative CheW interface [polypeptide binding]; other site 1117943016538 TIR domain; Region: TIR_2; pfam13676 1117943016539 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1117943016540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943016541 S-adenosylmethionine binding site [chemical binding]; other site 1117943016542 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1117943016543 Cytochrome c; Region: Cytochrom_C; pfam00034 1117943016544 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1117943016545 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1117943016546 catalytic residues [active] 1117943016547 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1117943016548 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1117943016549 Cu(I) binding site [ion binding]; other site 1117943016550 Protein of unknown function, DUF; Region: DUF411; cl01142 1117943016551 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1117943016552 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1117943016553 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1117943016554 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1117943016555 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1117943016556 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1117943016557 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943016558 YtkA-like; Region: YtkA; pfam13115 1117943016559 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1117943016560 metal-binding site [ion binding] 1117943016561 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1117943016562 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1117943016563 ligand binding site [chemical binding]; other site 1117943016564 flexible hinge region; other site 1117943016565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943016566 S-adenosylmethionine binding site [chemical binding]; other site 1117943016567 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943016568 putative DNA binding site [nucleotide binding]; other site 1117943016569 dimerization interface [polypeptide binding]; other site 1117943016570 putative Zn2+ binding site [ion binding]; other site 1117943016571 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1117943016572 putative hydrophobic ligand binding site [chemical binding]; other site 1117943016573 CLM binding site; other site 1117943016574 L1 loop; other site 1117943016575 DNA binding site [nucleotide binding] 1117943016576 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943016577 dimerization interface [polypeptide binding]; other site 1117943016578 putative DNA binding site [nucleotide binding]; other site 1117943016579 putative Zn2+ binding site [ion binding]; other site 1117943016580 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1117943016581 active site residue [active] 1117943016582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943016583 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1117943016584 putative substrate translocation pore; other site 1117943016585 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1117943016586 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1117943016587 metal-binding site [ion binding] 1117943016588 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1117943016589 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1117943016590 metal-binding site [ion binding] 1117943016591 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943016592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943016593 motif II; other site 1117943016594 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1117943016595 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1117943016596 DNA binding residues [nucleotide binding] 1117943016597 dimer interface [polypeptide binding]; other site 1117943016598 copper binding site [ion binding]; other site 1117943016599 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 1117943016600 putative homodimer interface [polypeptide binding]; other site 1117943016601 putative homotetramer interface [polypeptide binding]; other site 1117943016602 putative metal binding site [ion binding]; other site 1117943016603 putative homodimer-homodimer interface [polypeptide binding]; other site 1117943016604 putative allosteric switch controlling residues; other site 1117943016605 H+ Antiporter protein; Region: 2A0121; TIGR00900 1117943016606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943016607 putative substrate translocation pore; other site 1117943016608 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1117943016609 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1117943016610 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1117943016611 Cytochrome C' Region: Cytochrom_C_2; cl01610 1117943016612 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1117943016613 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943016614 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1117943016615 Domain of unknown function (DUF305); Region: DUF305; cl17794 1117943016616 Predicted membrane protein [Function unknown]; Region: COG1238 1117943016617 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1117943016618 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1117943016619 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1117943016620 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1117943016621 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1117943016622 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 1117943016623 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943016624 cyclase homology domain; Region: CHD; cd07302 1117943016625 nucleotidyl binding site; other site 1117943016626 metal binding site [ion binding]; metal-binding site 1117943016627 dimer interface [polypeptide binding]; other site 1117943016628 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1117943016629 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1117943016630 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1117943016631 [2Fe-2S] cluster binding site [ion binding]; other site 1117943016632 Ceramidase; Region: Ceramidase; pfam05875 1117943016633 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1117943016634 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1117943016635 conserved cys residue [active] 1117943016636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943016637 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943016638 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1117943016639 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1117943016640 conserved cys residue [active] 1117943016641 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 1117943016642 Dienelactone hydrolase family; Region: DLH; pfam01738 1117943016643 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943016644 binding surface 1117943016645 TPR motif; other site 1117943016646 GYD domain; Region: GYD; cl01743 1117943016647 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1117943016648 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943016649 Coenzyme A binding pocket [chemical binding]; other site 1117943016650 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1117943016651 hypothetical protein; Provisional; Region: PRK08317 1117943016652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943016653 S-adenosylmethionine binding site [chemical binding]; other site 1117943016654 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1117943016655 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1117943016656 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1117943016657 Integrase core domain; Region: rve; pfam00665 1117943016658 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1117943016659 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1117943016660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943016661 Walker A motif; other site 1117943016662 ATP binding site [chemical binding]; other site 1117943016663 Walker B motif; other site 1117943016664 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1117943016665 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943016666 Integrase core domain; Region: rve; pfam00665 1117943016667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943016668 transposase; Validated; Region: PRK08181 1117943016669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943016670 Walker A motif; other site 1117943016671 ATP binding site [chemical binding]; other site 1117943016672 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943016673 cyclase homology domain; Region: CHD; cd07302 1117943016674 nucleotidyl binding site; other site 1117943016675 metal binding site [ion binding]; metal-binding site 1117943016676 dimer interface [polypeptide binding]; other site 1117943016677 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943016678 TPR repeat; Region: TPR_11; pfam13414 1117943016679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943016680 binding surface 1117943016681 TPR motif; other site 1117943016682 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943016683 TPR motif; other site 1117943016684 binding surface 1117943016685 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943016686 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943016687 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1117943016688 Coenzyme A binding pocket [chemical binding]; other site 1117943016689 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1117943016690 nucleoside/Zn binding site; other site 1117943016691 dimer interface [polypeptide binding]; other site 1117943016692 catalytic motif [active] 1117943016693 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 1117943016694 PAS fold; Region: PAS_7; pfam12860 1117943016695 PAS fold; Region: PAS_4; pfam08448 1117943016696 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943016697 putative active site [active] 1117943016698 heme pocket [chemical binding]; other site 1117943016699 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1117943016700 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1117943016701 DNA-binding site [nucleotide binding]; DNA binding site 1117943016702 RNA-binding motif; other site 1117943016703 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943016704 ATP binding site [chemical binding]; other site 1117943016705 Walker B motif; other site 1117943016706 arginine finger; other site 1117943016707 Peptidase family M41; Region: Peptidase_M41; pfam01434 1117943016708 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1117943016709 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 1117943016710 putative active site [active] 1117943016711 putative metal binding site [ion binding]; other site 1117943016712 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1117943016713 EamA-like transporter family; Region: EamA; pfam00892 1117943016714 EamA-like transporter family; Region: EamA; pfam00892 1117943016715 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1117943016716 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1117943016717 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 1117943016718 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 1117943016719 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1117943016720 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1117943016721 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1117943016722 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1117943016723 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1117943016724 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1117943016725 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1117943016726 TadE-like protein; Region: TadE; pfam07811 1117943016727 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1117943016728 TadE-like protein; Region: TadE; pfam07811 1117943016729 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1117943016730 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 1117943016731 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1117943016732 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1117943016733 ATP binding site [chemical binding]; other site 1117943016734 Walker A motif; other site 1117943016735 hexamer interface [polypeptide binding]; other site 1117943016736 Walker B motif; other site 1117943016737 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1117943016738 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1117943016739 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1117943016740 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1117943016741 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1117943016742 CheB methylesterase; Region: CheB_methylest; pfam01339 1117943016743 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1117943016744 putative binding surface; other site 1117943016745 active site 1117943016746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943016747 ATP binding site [chemical binding]; other site 1117943016748 Mg2+ binding site [ion binding]; other site 1117943016749 G-X-G motif; other site 1117943016750 CheW-like domain; Region: CheW; pfam01584 1117943016751 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1117943016752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943016753 active site 1117943016754 phosphorylation site [posttranslational modification] 1117943016755 intermolecular recognition site; other site 1117943016756 dimerization interface [polypeptide binding]; other site 1117943016757 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1117943016758 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1117943016759 dimerization interface [polypeptide binding]; other site 1117943016760 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1117943016761 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1117943016762 dimer interface [polypeptide binding]; other site 1117943016763 putative CheW interface [polypeptide binding]; other site 1117943016764 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1117943016765 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1117943016766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943016767 S-adenosylmethionine binding site [chemical binding]; other site 1117943016768 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1117943016769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943016770 active site 1117943016771 phosphorylation site [posttranslational modification] 1117943016772 intermolecular recognition site; other site 1117943016773 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943016774 DNA binding residues [nucleotide binding] 1117943016775 dimerization interface [polypeptide binding]; other site 1117943016776 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1117943016777 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1117943016778 PAS domain; Region: PAS_8; pfam13188 1117943016779 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1117943016780 Membrane-associating domain; Region: MARVEL; pfam01284 1117943016781 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1117943016782 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943016783 metal binding site [ion binding]; metal-binding site 1117943016784 active site 1117943016785 I-site; other site 1117943016786 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943016787 cyclase homology domain; Region: CHD; cd07302 1117943016788 nucleotidyl binding site; other site 1117943016789 metal binding site [ion binding]; metal-binding site 1117943016790 dimer interface [polypeptide binding]; other site 1117943016791 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1117943016792 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1117943016793 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1117943016794 DNA binding site [nucleotide binding] 1117943016795 active site 1117943016796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1117943016797 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943016798 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1117943016799 acetylornithine deacetylase; Provisional; Region: PRK07522 1117943016800 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1117943016801 metal binding site [ion binding]; metal-binding site 1117943016802 putative dimer interface [polypeptide binding]; other site 1117943016803 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1117943016804 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1117943016805 putative ligand binding site [chemical binding]; other site 1117943016806 NAD binding site [chemical binding]; other site 1117943016807 dimerization interface [polypeptide binding]; other site 1117943016808 catalytic site [active] 1117943016809 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1117943016810 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1117943016811 Coenzyme A binding pocket [chemical binding]; other site 1117943016812 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1117943016813 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1117943016814 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1117943016815 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1117943016816 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1117943016817 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1117943016818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943016819 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943016820 dimerization interface [polypeptide binding]; other site 1117943016821 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1117943016822 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1117943016823 NAD(P) binding site [chemical binding]; other site 1117943016824 catalytic residues [active] 1117943016825 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1117943016826 tartrate dehydrogenase; Region: TTC; TIGR02089 1117943016827 succinic semialdehyde dehydrogenase; Region: PLN02278 1117943016828 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1117943016829 tetramerization interface [polypeptide binding]; other site 1117943016830 NAD(P) binding site [chemical binding]; other site 1117943016831 catalytic residues [active] 1117943016832 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1117943016833 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1117943016834 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1117943016835 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1117943016836 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 1117943016837 putative N-terminal domain interface [polypeptide binding]; other site 1117943016838 putative dimer interface [polypeptide binding]; other site 1117943016839 putative substrate binding pocket (H-site) [chemical binding]; other site 1117943016840 transcriptional regulator; Provisional; Region: PRK10632 1117943016841 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943016842 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 1117943016843 putative effector binding pocket; other site 1117943016844 putative dimerization interface [polypeptide binding]; other site 1117943016845 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1117943016846 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943016847 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1117943016848 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 1117943016849 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1117943016850 hypothetical protein; Provisional; Region: PRK05965 1117943016851 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1117943016852 inhibitor-cofactor binding pocket; inhibition site 1117943016853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943016854 catalytic residue [active] 1117943016855 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1117943016856 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 1117943016857 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1117943016858 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1117943016859 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1117943016860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943016861 dimer interface [polypeptide binding]; other site 1117943016862 conserved gate region; other site 1117943016863 putative PBP binding loops; other site 1117943016864 ABC-ATPase subunit interface; other site 1117943016865 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1117943016866 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943016867 Walker A/P-loop; other site 1117943016868 ATP binding site [chemical binding]; other site 1117943016869 Q-loop/lid; other site 1117943016870 ABC transporter signature motif; other site 1117943016871 Walker B; other site 1117943016872 D-loop; other site 1117943016873 H-loop/switch region; other site 1117943016874 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943016875 Walker A/P-loop; other site 1117943016876 ATP binding site [chemical binding]; other site 1117943016877 Q-loop/lid; other site 1117943016878 ABC transporter signature motif; other site 1117943016879 Walker B; other site 1117943016880 D-loop; other site 1117943016881 H-loop/switch region; other site 1117943016882 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1117943016883 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1117943016884 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1117943016885 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1117943016886 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1117943016887 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1117943016888 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1117943016889 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1117943016890 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 1117943016891 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1117943016892 TadE-like protein; Region: TadE; pfam07811 1117943016893 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1117943016894 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1117943016895 TadE-like protein; Region: TadE; pfam07811 1117943016896 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 1117943016897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1117943016898 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1117943016899 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1117943016900 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1117943016901 ATP binding site [chemical binding]; other site 1117943016902 Walker A motif; other site 1117943016903 hexamer interface [polypeptide binding]; other site 1117943016904 Walker B motif; other site 1117943016905 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1117943016906 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1117943016907 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1117943016908 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1117943016909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1117943016910 Walker A motif; other site 1117943016911 ATP binding site [chemical binding]; other site 1117943016912 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943016913 TPR motif; other site 1117943016914 binding surface 1117943016915 TPR repeat; Region: TPR_11; pfam13414 1117943016916 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1117943016917 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1117943016918 putative di-iron ligands [ion binding]; other site 1117943016919 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1117943016920 DNA-binding site [nucleotide binding]; DNA binding site 1117943016921 RNA-binding motif; other site 1117943016922 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943016923 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943016924 putative DNA binding site [nucleotide binding]; other site 1117943016925 putative Zn2+ binding site [ion binding]; other site 1117943016926 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943016927 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943016928 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1117943016929 HlyD family secretion protein; Region: HlyD; pfam00529 1117943016930 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1117943016931 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943016932 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1117943016933 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1117943016934 Walker A/P-loop; other site 1117943016935 ATP binding site [chemical binding]; other site 1117943016936 Q-loop/lid; other site 1117943016937 ABC transporter signature motif; other site 1117943016938 Walker B; other site 1117943016939 D-loop; other site 1117943016940 H-loop/switch region; other site 1117943016941 hypothetical protein; Provisional; Region: PRK07505 1117943016942 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1117943016943 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1117943016944 catalytic residue [active] 1117943016945 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1117943016946 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943016947 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943016948 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943016949 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943016950 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943016951 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943016952 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943016953 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943016954 Response regulator receiver domain; Region: Response_reg; pfam00072 1117943016955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943016956 active site 1117943016957 phosphorylation site [posttranslational modification] 1117943016958 intermolecular recognition site; other site 1117943016959 dimerization interface [polypeptide binding]; other site 1117943016960 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1117943016961 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1117943016962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1117943016963 phosphorylation site [posttranslational modification] 1117943016964 intermolecular recognition site; other site 1117943016965 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943016966 DNA binding site [nucleotide binding] 1117943016967 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1117943016968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943016969 NAD(P) binding site [chemical binding]; other site 1117943016970 active site 1117943016971 acetolactate synthase catalytic subunit; Validated; Region: PRK06112 1117943016972 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1117943016973 PYR/PP interface [polypeptide binding]; other site 1117943016974 dimer interface [polypeptide binding]; other site 1117943016975 TPP binding site [chemical binding]; other site 1117943016976 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1117943016977 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1117943016978 TPP-binding site [chemical binding]; other site 1117943016979 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1117943016980 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1117943016981 inhibitor-cofactor binding pocket; inhibition site 1117943016982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943016983 catalytic residue [active] 1117943016984 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943016985 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943016986 DNA-binding site [nucleotide binding]; DNA binding site 1117943016987 FCD domain; Region: FCD; pfam07729 1117943016988 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1117943016989 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943016990 Walker A/P-loop; other site 1117943016991 ATP binding site [chemical binding]; other site 1117943016992 Q-loop/lid; other site 1117943016993 ABC transporter signature motif; other site 1117943016994 Walker B; other site 1117943016995 D-loop; other site 1117943016996 H-loop/switch region; other site 1117943016997 TOBE domain; Region: TOBE_2; pfam08402 1117943016998 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1117943016999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943017000 dimer interface [polypeptide binding]; other site 1117943017001 conserved gate region; other site 1117943017002 putative PBP binding loops; other site 1117943017003 ABC-ATPase subunit interface; other site 1117943017004 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1117943017005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943017006 dimer interface [polypeptide binding]; other site 1117943017007 conserved gate region; other site 1117943017008 putative PBP binding loops; other site 1117943017009 ABC-ATPase subunit interface; other site 1117943017010 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1117943017011 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943017012 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 1117943017013 MobA/MobL family; Region: MobA_MobL; pfam03389 1117943017014 AAA domain; Region: AAA_30; pfam13604 1117943017015 Family description; Region: UvrD_C_2; pfam13538 1117943017016 Conjugal transfer protein TraD; Region: TraD; pfam06412 1117943017017 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 1117943017018 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 1117943017019 Walker A motif; other site 1117943017020 ATP binding site [chemical binding]; other site 1117943017021 Walker B motif; other site 1117943017022 Uncharacterized conserved protein [Function unknown]; Region: COG5489 1117943017023 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1117943017024 putative active site [active] 1117943017025 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1117943017026 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1117943017027 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 1117943017028 Toprim domain; Region: Toprim_3; pfam13362 1117943017029 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 1117943017030 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1117943017031 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1117943017032 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1117943017033 putative cation:proton antiport protein; Provisional; Region: PRK10669 1117943017034 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1117943017035 TrkA-N domain; Region: TrkA_N; pfam02254 1117943017036 alkylmercury lyase; Provisional; Region: PRK13239 1117943017037 Alkylmercury lyase; Region: MerB; pfam03243 1117943017038 mercuric reductase; Region: MerA; TIGR02053 1117943017039 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1117943017040 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1117943017041 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1117943017042 metal-binding site [ion binding] 1117943017043 MerT mercuric transport protein; Region: MerT; cl03578 1117943017044 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 1117943017045 DNA binding residues [nucleotide binding] 1117943017046 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 1117943017047 dimer interface [polypeptide binding]; other site 1117943017048 putative metal binding site [ion binding]; other site 1117943017049 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1117943017050 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1117943017051 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 1117943017052 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1117943017053 Walker A motif; other site 1117943017054 hexamer interface [polypeptide binding]; other site 1117943017055 ATP binding site [chemical binding]; other site 1117943017056 Walker B motif; other site 1117943017057 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 1117943017058 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1117943017059 VirB7 interaction site; other site 1117943017060 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 1117943017061 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 1117943017062 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 1117943017063 Type IV secretion system proteins; Region: T4SS; pfam07996 1117943017064 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 1117943017065 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1117943017066 Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702 1117943017067 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 1117943017068 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1117943017069 MarR family; Region: MarR_2; cl17246 1117943017070 Fic family protein [Function unknown]; Region: COG3177 1117943017071 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 1117943017072 Fic/DOC family; Region: Fic; pfam02661 1117943017073 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1117943017074 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1117943017075 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1117943017076 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1117943017077 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1117943017078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943017079 Walker A motif; other site 1117943017080 ATP binding site [chemical binding]; other site 1117943017081 Walker B motif; other site 1117943017082 arginine finger; other site 1117943017083 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1117943017084 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943017085 Integrase core domain; Region: rve; pfam00665 1117943017086 transposase; Validated; Region: PRK08181 1117943017087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943017088 Walker A motif; other site 1117943017089 ATP binding site [chemical binding]; other site 1117943017090 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943017091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943017092 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943017093 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1117943017094 active site 1117943017095 NTP binding site [chemical binding]; other site 1117943017096 metal binding triad [ion binding]; metal-binding site 1117943017097 antibiotic binding site [chemical binding]; other site 1117943017098 Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748 1117943017099 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1117943017100 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1117943017101 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1117943017102 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1117943017103 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1117943017104 Walker A/P-loop; other site 1117943017105 ATP binding site [chemical binding]; other site 1117943017106 Q-loop/lid; other site 1117943017107 ABC transporter signature motif; other site 1117943017108 Walker B; other site 1117943017109 D-loop; other site 1117943017110 H-loop/switch region; other site 1117943017111 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 1117943017112 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1117943017113 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1117943017114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943017115 Walker A motif; other site 1117943017116 ATP binding site [chemical binding]; other site 1117943017117 Walker B motif; other site 1117943017118 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1117943017119 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943017120 Integrase core domain; Region: rve; pfam00665 1117943017121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943017122 Transposase; Region: HTH_Tnp_1; cl17663 1117943017123 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943017124 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943017125 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943017126 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943017127 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943017128 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943017129 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943017130 Winged helix-turn helix; Region: HTH_33; pfam13592 1117943017131 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943017132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943017133 pseudaminic acid synthase; Region: PseI; TIGR03586 1117943017134 NeuB family; Region: NeuB; pfam03102 1117943017135 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1117943017136 NeuB binding interface [polypeptide binding]; other site 1117943017137 putative substrate binding site [chemical binding]; other site 1117943017138 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 1117943017139 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1117943017140 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 1117943017141 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1117943017142 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1117943017143 ligand binding site; other site 1117943017144 tetramer interface; other site 1117943017145 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1117943017146 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1117943017147 inhibitor-cofactor binding pocket; inhibition site 1117943017148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943017149 catalytic residue [active] 1117943017150 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1117943017151 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1117943017152 NAD(P) binding site [chemical binding]; other site 1117943017153 homodimer interface [polypeptide binding]; other site 1117943017154 substrate binding site [chemical binding]; other site 1117943017155 active site 1117943017156 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1117943017157 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1117943017158 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1117943017159 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 1117943017160 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1117943017161 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1117943017162 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1117943017163 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1117943017164 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1117943017165 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 1117943017166 Walker A/P-loop; other site 1117943017167 ATP binding site [chemical binding]; other site 1117943017168 Q-loop/lid; other site 1117943017169 ABC transporter signature motif; other site 1117943017170 Walker B; other site 1117943017171 D-loop; other site 1117943017172 H-loop/switch region; other site 1117943017173 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; cl17608 1117943017174 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1117943017175 active site 1117943017176 catalytic residues [active] 1117943017177 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1117943017178 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943017179 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 1117943017180 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1117943017181 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1117943017182 putative active site [active] 1117943017183 putative substrate binding site [chemical binding]; other site 1117943017184 putative cosubstrate binding site; other site 1117943017185 catalytic site [active] 1117943017186 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 1117943017187 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1117943017188 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1117943017189 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 1117943017190 active site 1117943017191 FMN binding site [chemical binding]; other site 1117943017192 substrate binding site [chemical binding]; other site 1117943017193 3Fe-4S cluster binding site [ion binding]; other site 1117943017194 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 1117943017195 domain_subunit interface; other site 1117943017196 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1117943017197 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 1117943017198 putative active site [active] 1117943017199 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943017200 non-specific DNA binding site [nucleotide binding]; other site 1117943017201 salt bridge; other site 1117943017202 sequence-specific DNA binding site [nucleotide binding]; other site 1117943017203 Cupin domain; Region: Cupin_2; pfam07883 1117943017204 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1117943017205 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1117943017206 conserved cys residue [active] 1117943017207 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943017208 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1117943017209 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1117943017210 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 1117943017211 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1117943017212 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1117943017213 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1117943017214 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1117943017215 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1117943017216 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1117943017217 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1117943017218 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943017219 protein binding site [polypeptide binding]; other site 1117943017220 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943017221 OsmC-like protein; Region: OsmC; cl00767 1117943017222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943017223 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1117943017224 putative substrate translocation pore; other site 1117943017225 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1117943017226 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943017227 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1117943017228 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1117943017229 inhibitor site; inhibition site 1117943017230 active site 1117943017231 dimer interface [polypeptide binding]; other site 1117943017232 catalytic residue [active] 1117943017233 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1117943017234 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1117943017235 DctM-like transporters; Region: DctM; pfam06808 1117943017236 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1117943017237 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1117943017238 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943017239 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943017240 DNA-binding site [nucleotide binding]; DNA binding site 1117943017241 FCD domain; Region: FCD; pfam07729 1117943017242 PilZ domain; Region: PilZ; cl01260 1117943017243 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 1117943017244 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1117943017245 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1117943017246 metal binding site [ion binding]; metal-binding site 1117943017247 active site 1117943017248 I-site; other site 1117943017249 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1117943017250 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1117943017251 OsmC-like protein; Region: OsmC; cl00767 1117943017252 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 1117943017253 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1117943017254 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943017255 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1117943017256 EamA-like transporter family; Region: EamA; pfam00892 1117943017257 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1117943017258 MarR family; Region: MarR; pfam01047 1117943017259 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1117943017260 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 1117943017261 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1117943017262 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1117943017263 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1117943017264 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1117943017265 putative active site [active] 1117943017266 catalytic residue [active] 1117943017267 aconitate hydratase; Provisional; Region: acnA; PRK12881 1117943017268 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1117943017269 substrate binding site [chemical binding]; other site 1117943017270 ligand binding site [chemical binding]; other site 1117943017271 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1117943017272 substrate binding site [chemical binding]; other site 1117943017273 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943017274 DNA-binding site [nucleotide binding]; DNA binding site 1117943017275 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943017276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1117943017277 DNA-binding site [nucleotide binding]; DNA binding site 1117943017278 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1117943017279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1117943017280 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1117943017281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1117943017282 YCII-related domain; Region: YCII; cl00999 1117943017283 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943017284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943017285 DNA-binding site [nucleotide binding]; DNA binding site 1117943017286 FCD domain; Region: FCD; pfam07729 1117943017287 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943017288 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943017289 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1117943017290 substrate binding pocket [chemical binding]; other site 1117943017291 dimerization interface [polypeptide binding]; other site 1117943017292 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1117943017293 Cytochrome P450; Region: p450; cl12078 1117943017294 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1117943017295 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1117943017296 catalytic loop [active] 1117943017297 iron binding site [ion binding]; other site 1117943017298 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1117943017299 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1117943017300 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1117943017301 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 1117943017302 putative active site [active] 1117943017303 putative metal binding site [ion binding]; other site 1117943017304 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943017305 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943017306 putative DNA binding site [nucleotide binding]; other site 1117943017307 putative Zn2+ binding site [ion binding]; other site 1117943017308 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943017309 HipA N-terminal domain; Region: Couple_hipA; cl11853 1117943017310 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1117943017311 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1117943017312 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943017313 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943017314 non-specific DNA binding site [nucleotide binding]; other site 1117943017315 salt bridge; other site 1117943017316 sequence-specific DNA binding site [nucleotide binding]; other site 1117943017317 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943017318 cyclase homology domain; Region: CHD; cd07302 1117943017319 nucleotidyl binding site; other site 1117943017320 metal binding site [ion binding]; metal-binding site 1117943017321 dimer interface [polypeptide binding]; other site 1117943017322 Predicted ATPase [General function prediction only]; Region: COG3903 1117943017323 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1117943017324 Uncharacterized conserved protein [Function unknown]; Region: COG3482 1117943017325 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 1117943017326 YcaO-like family; Region: YcaO; pfam02624 1117943017327 Adenosine specific kinase; Region: Adenosine_kin; cl00796 1117943017328 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1117943017329 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1117943017330 Walker A/P-loop; other site 1117943017331 ATP binding site [chemical binding]; other site 1117943017332 Q-loop/lid; other site 1117943017333 ABC transporter signature motif; other site 1117943017334 Walker B; other site 1117943017335 D-loop; other site 1117943017336 H-loop/switch region; other site 1117943017337 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1117943017338 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943017339 substrate binding pocket [chemical binding]; other site 1117943017340 membrane-bound complex binding site; other site 1117943017341 hinge residues; other site 1117943017342 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1117943017343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943017344 dimer interface [polypeptide binding]; other site 1117943017345 conserved gate region; other site 1117943017346 putative PBP binding loops; other site 1117943017347 ABC-ATPase subunit interface; other site 1117943017348 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1117943017349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943017350 dimer interface [polypeptide binding]; other site 1117943017351 conserved gate region; other site 1117943017352 putative PBP binding loops; other site 1117943017353 ABC-ATPase subunit interface; other site 1117943017354 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1117943017355 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1117943017356 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1117943017357 catalytic residue [active] 1117943017358 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 1117943017359 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1117943017360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943017361 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1117943017362 putative substrate translocation pore; other site 1117943017363 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943017364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943017365 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1117943017366 putative substrate binding pocket [chemical binding]; other site 1117943017367 putative dimerization interface [polypeptide binding]; other site 1117943017368 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1117943017369 FO synthase; Reviewed; Region: fbiC; PRK09234 1117943017370 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1117943017371 Histidine kinase; Region: HisKA_3; pfam07730 1117943017372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943017373 ATP binding site [chemical binding]; other site 1117943017374 Mg2+ binding site [ion binding]; other site 1117943017375 G-X-G motif; other site 1117943017376 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1117943017377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943017378 active site 1117943017379 phosphorylation site [posttranslational modification] 1117943017380 intermolecular recognition site; other site 1117943017381 dimerization interface [polypeptide binding]; other site 1117943017382 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943017383 DNA binding residues [nucleotide binding] 1117943017384 dimerization interface [polypeptide binding]; other site 1117943017385 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1117943017386 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1117943017387 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1117943017388 putative hydrophobic ligand binding site [chemical binding]; other site 1117943017389 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943017390 cyclase homology domain; Region: CHD; cd07302 1117943017391 nucleotidyl binding site; other site 1117943017392 metal binding site [ion binding]; metal-binding site 1117943017393 dimer interface [polypeptide binding]; other site 1117943017394 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943017395 dimer interface [polypeptide binding]; other site 1117943017396 phosphorylation site [posttranslational modification] 1117943017397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943017398 ATP binding site [chemical binding]; other site 1117943017399 Mg2+ binding site [ion binding]; other site 1117943017400 G-X-G motif; other site 1117943017401 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1117943017402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943017403 active site 1117943017404 phosphorylation site [posttranslational modification] 1117943017405 intermolecular recognition site; other site 1117943017406 dimerization interface [polypeptide binding]; other site 1117943017407 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943017408 DNA binding residues [nucleotide binding] 1117943017409 dimerization interface [polypeptide binding]; other site 1117943017410 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1117943017411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943017412 active site 1117943017413 phosphorylation site [posttranslational modification] 1117943017414 intermolecular recognition site; other site 1117943017415 dimerization interface [polypeptide binding]; other site 1117943017416 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1117943017417 Sulfatase; Region: Sulfatase; pfam00884 1117943017418 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1117943017419 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943017420 motif II; other site 1117943017421 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1117943017422 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1117943017423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 1117943017424 Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865 1117943017425 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943017426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943017427 TPR motif; other site 1117943017428 binding surface 1117943017429 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 1117943017430 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 1117943017431 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1117943017432 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1117943017433 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1117943017434 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1117943017435 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1117943017436 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943017437 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1117943017438 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1117943017439 FeS/SAM binding site; other site 1117943017440 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1117943017441 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 1117943017442 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1117943017443 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1117943017444 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1117943017445 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1117943017446 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 1117943017447 dimer interface [polypeptide binding]; other site 1117943017448 Trp docking motif [polypeptide binding]; other site 1117943017449 active site 1117943017450 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1117943017451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943017452 active site 1117943017453 phosphorylation site [posttranslational modification] 1117943017454 intermolecular recognition site; other site 1117943017455 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943017456 DNA binding residues [nucleotide binding] 1117943017457 dimerization interface [polypeptide binding]; other site 1117943017458 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1117943017459 FIST N domain; Region: FIST; pfam08495 1117943017460 FIST C domain; Region: FIST_C; pfam10442 1117943017461 PAS fold; Region: PAS_7; pfam12860 1117943017462 PAS fold; Region: PAS_7; pfam12860 1117943017463 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943017464 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1117943017465 dimer interface [polypeptide binding]; other site 1117943017466 phosphorylation site [posttranslational modification] 1117943017467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943017468 ATP binding site [chemical binding]; other site 1117943017469 Mg2+ binding site [ion binding]; other site 1117943017470 G-X-G motif; other site 1117943017471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943017472 Response regulator receiver domain; Region: Response_reg; pfam00072 1117943017473 active site 1117943017474 phosphorylation site [posttranslational modification] 1117943017475 intermolecular recognition site; other site 1117943017476 dimerization interface [polypeptide binding]; other site 1117943017477 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1117943017478 pseudoazurin; Region: pseudoazurin; TIGR02375 1117943017479 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1117943017480 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1117943017481 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1117943017482 structural tetrad; other site 1117943017483 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1117943017484 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1117943017485 ligand binding site [chemical binding]; other site 1117943017486 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1117943017487 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943017488 substrate binding pocket [chemical binding]; other site 1117943017489 membrane-bound complex binding site; other site 1117943017490 hinge residues; other site 1117943017491 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1117943017492 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1117943017493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1117943017494 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1117943017495 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1117943017496 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1117943017497 Walker A/P-loop; other site 1117943017498 ATP binding site [chemical binding]; other site 1117943017499 Q-loop/lid; other site 1117943017500 ABC transporter signature motif; other site 1117943017501 Walker B; other site 1117943017502 D-loop; other site 1117943017503 H-loop/switch region; other site 1117943017504 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1117943017505 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1117943017506 Walker A/P-loop; other site 1117943017507 ATP binding site [chemical binding]; other site 1117943017508 Q-loop/lid; other site 1117943017509 ABC transporter signature motif; other site 1117943017510 Walker B; other site 1117943017511 D-loop; other site 1117943017512 H-loop/switch region; other site 1117943017513 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1117943017514 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1117943017515 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1117943017516 TM-ABC transporter signature motif; other site 1117943017517 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943017518 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1117943017519 TM-ABC transporter signature motif; other site 1117943017520 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1117943017521 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1117943017522 dimerization interface [polypeptide binding]; other site 1117943017523 ligand binding site [chemical binding]; other site 1117943017524 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1117943017525 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1117943017526 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1117943017527 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1117943017528 aspartate aminotransferase; Provisional; Region: PRK05764 1117943017529 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943017530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943017531 homodimer interface [polypeptide binding]; other site 1117943017532 catalytic residue [active] 1117943017533 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1117943017534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943017535 NAD(P) binding site [chemical binding]; other site 1117943017536 active site 1117943017537 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943017538 thiamine pyrophosphate protein; Validated; Region: PRK08199 1117943017539 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1117943017540 PYR/PP interface [polypeptide binding]; other site 1117943017541 dimer interface [polypeptide binding]; other site 1117943017542 TPP binding site [chemical binding]; other site 1117943017543 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1117943017544 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1117943017545 TPP-binding site [chemical binding]; other site 1117943017546 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1117943017547 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943017548 DNA-binding site [nucleotide binding]; DNA binding site 1117943017549 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1117943017550 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1117943017551 FAD binding domain; Region: FAD_binding_4; pfam01565 1117943017552 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1117943017553 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1117943017554 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1117943017555 classical (c) SDRs; Region: SDR_c; cd05233 1117943017556 NAD(P) binding site [chemical binding]; other site 1117943017557 active site 1117943017558 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1117943017559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943017560 NAD(P) binding site [chemical binding]; other site 1117943017561 active site 1117943017562 Cache domain; Region: Cache_1; pfam02743 1117943017563 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943017564 cyclase homology domain; Region: CHD; cd07302 1117943017565 nucleotidyl binding site; other site 1117943017566 metal binding site [ion binding]; metal-binding site 1117943017567 dimer interface [polypeptide binding]; other site 1117943017568 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1117943017569 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1117943017570 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1117943017571 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1117943017572 clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934 1117943017573 NADP binding site [chemical binding]; other site 1117943017574 homotetramer interface [polypeptide binding]; other site 1117943017575 homodimer interface [polypeptide binding]; other site 1117943017576 active site 1117943017577 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1117943017578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943017579 putative substrate translocation pore; other site 1117943017580 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943017581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943017582 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1117943017583 putative effector binding pocket; other site 1117943017584 putative dimerization interface [polypeptide binding]; other site 1117943017585 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1117943017586 ThiC-associated domain; Region: ThiC-associated; pfam13667 1117943017587 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1117943017588 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1117943017589 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1117943017590 thiS-thiF/thiG interaction site; other site 1117943017591 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1117943017592 ThiS interaction site; other site 1117943017593 putative active site [active] 1117943017594 tetramer interface [polypeptide binding]; other site 1117943017595 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1117943017596 thiamine phosphate binding site [chemical binding]; other site 1117943017597 active site 1117943017598 pyrophosphate binding site [ion binding]; other site 1117943017599 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1117943017600 oligomeric interface; other site 1117943017601 putative active site [active] 1117943017602 homodimer interface [polypeptide binding]; other site 1117943017603 prevent-host-death family protein; Region: phd_fam; TIGR01552 1117943017604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943017605 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943017606 DNA-binding site [nucleotide binding]; DNA binding site 1117943017607 FCD domain; Region: FCD; pfam07729 1117943017608 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 1117943017609 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 1117943017610 malonyl-CoA synthase; Validated; Region: PRK07514 1117943017611 acyl-activating enzyme (AAE) consensus motif; other site 1117943017612 active site 1117943017613 AMP binding site [chemical binding]; other site 1117943017614 CoA binding site [chemical binding]; other site 1117943017615 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 1117943017616 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1117943017617 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1117943017618 alpha-galactosidase; Provisional; Region: PRK15076 1117943017619 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1117943017620 NAD binding site [chemical binding]; other site 1117943017621 sugar binding site [chemical binding]; other site 1117943017622 divalent metal binding site [ion binding]; other site 1117943017623 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1117943017624 dimer interface [polypeptide binding]; other site 1117943017625 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1117943017626 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943017627 Walker A/P-loop; other site 1117943017628 ATP binding site [chemical binding]; other site 1117943017629 Q-loop/lid; other site 1117943017630 ABC transporter signature motif; other site 1117943017631 Walker B; other site 1117943017632 D-loop; other site 1117943017633 H-loop/switch region; other site 1117943017634 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1117943017635 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943017636 Walker A/P-loop; other site 1117943017637 ATP binding site [chemical binding]; other site 1117943017638 Q-loop/lid; other site 1117943017639 ABC transporter signature motif; other site 1117943017640 Walker B; other site 1117943017641 D-loop; other site 1117943017642 H-loop/switch region; other site 1117943017643 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1117943017644 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1117943017645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943017646 dimer interface [polypeptide binding]; other site 1117943017647 conserved gate region; other site 1117943017648 putative PBP binding loops; other site 1117943017649 ABC-ATPase subunit interface; other site 1117943017650 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1117943017651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943017652 dimer interface [polypeptide binding]; other site 1117943017653 conserved gate region; other site 1117943017654 putative PBP binding loops; other site 1117943017655 ABC-ATPase subunit interface; other site 1117943017656 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 1117943017657 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1117943017658 alpha-galactosidase; Provisional; Region: PRK15076 1117943017659 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1117943017660 NAD binding site [chemical binding]; other site 1117943017661 sugar binding site [chemical binding]; other site 1117943017662 divalent metal binding site [ion binding]; other site 1117943017663 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1117943017664 dimer interface [polypeptide binding]; other site 1117943017665 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1117943017666 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1117943017667 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943017668 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1117943017669 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1117943017670 putative ligand binding site [chemical binding]; other site 1117943017671 putative dimerization interface [polypeptide binding]; other site 1117943017672 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1117943017673 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1117943017674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1117943017675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943017676 putative PBP binding loops; other site 1117943017677 ABC-ATPase subunit interface; other site 1117943017678 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1117943017679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943017680 dimer interface [polypeptide binding]; other site 1117943017681 conserved gate region; other site 1117943017682 putative PBP binding loops; other site 1117943017683 ABC-ATPase subunit interface; other site 1117943017684 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1117943017685 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1117943017686 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1117943017687 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1117943017688 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1117943017689 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1117943017690 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1117943017691 Walker A/P-loop; other site 1117943017692 ATP binding site [chemical binding]; other site 1117943017693 Q-loop/lid; other site 1117943017694 ABC transporter signature motif; other site 1117943017695 Walker B; other site 1117943017696 D-loop; other site 1117943017697 H-loop/switch region; other site 1117943017698 TOBE domain; Region: TOBE_2; pfam08402 1117943017699 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1117943017700 aspartate racemase; Region: asp_race; TIGR00035 1117943017701 cell density-dependent motility repressor; Provisional; Region: PRK10082 1117943017702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943017703 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1117943017704 dimerization interface [polypeptide binding]; other site 1117943017705 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1117943017706 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943017707 substrate binding pocket [chemical binding]; other site 1117943017708 membrane-bound complex binding site; other site 1117943017709 hinge residues; other site 1117943017710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943017711 dimer interface [polypeptide binding]; other site 1117943017712 conserved gate region; other site 1117943017713 putative PBP binding loops; other site 1117943017714 ABC-ATPase subunit interface; other site 1117943017715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943017716 dimer interface [polypeptide binding]; other site 1117943017717 conserved gate region; other site 1117943017718 putative PBP binding loops; other site 1117943017719 ABC-ATPase subunit interface; other site 1117943017720 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1117943017721 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1117943017722 Walker A/P-loop; other site 1117943017723 ATP binding site [chemical binding]; other site 1117943017724 Q-loop/lid; other site 1117943017725 ABC transporter signature motif; other site 1117943017726 Walker B; other site 1117943017727 D-loop; other site 1117943017728 H-loop/switch region; other site 1117943017729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943017730 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1117943017731 Walker A/P-loop; other site 1117943017732 ATP binding site [chemical binding]; other site 1117943017733 Q-loop/lid; other site 1117943017734 ABC transporter signature motif; other site 1117943017735 Walker B; other site 1117943017736 D-loop; other site 1117943017737 H-loop/switch region; other site 1117943017738 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1117943017739 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1117943017740 Walker A/P-loop; other site 1117943017741 ATP binding site [chemical binding]; other site 1117943017742 Q-loop/lid; other site 1117943017743 ABC transporter signature motif; other site 1117943017744 Walker B; other site 1117943017745 D-loop; other site 1117943017746 H-loop/switch region; other site 1117943017747 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1117943017748 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1117943017749 TM-ABC transporter signature motif; other site 1117943017750 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943017751 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1117943017752 TM-ABC transporter signature motif; other site 1117943017753 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1117943017754 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1117943017755 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1117943017756 amidase; Provisional; Region: PRK07235 1117943017757 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1117943017758 Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816 1117943017759 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1117943017760 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1117943017761 putative active site [active] 1117943017762 catalytic triad [active] 1117943017763 putative dimer interface [polypeptide binding]; other site 1117943017764 Bacterial transcriptional regulator; Region: IclR; pfam01614 1117943017765 Transposase domain (DUF772); Region: DUF772; pfam05598 1117943017766 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943017767 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1117943017768 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1117943017769 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1117943017770 RES domain; Region: RES; cl02411 1117943017771 Transposase; Region: HTH_Tnp_1; cl17663 1117943017772 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1117943017773 transcriptional regulator TraR; Provisional; Region: PRK13870 1117943017774 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943017775 DNA binding residues [nucleotide binding] 1117943017776 dimerization interface [polypeptide binding]; other site 1117943017777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943017778 S-adenosylmethionine binding site [chemical binding]; other site 1117943017779 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1117943017780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943017781 Coenzyme A binding pocket [chemical binding]; other site 1117943017782 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943017783 cyclase homology domain; Region: CHD; cd07302 1117943017784 nucleotidyl binding site; other site 1117943017785 metal binding site [ion binding]; metal-binding site 1117943017786 dimer interface [polypeptide binding]; other site 1117943017787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943017788 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1117943017789 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1117943017790 putative effector binding pocket; other site 1117943017791 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1117943017792 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1117943017793 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1117943017794 Transmembrane secretion effector; Region: MFS_3; pfam05977 1117943017795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943017796 putative substrate translocation pore; other site 1117943017797 Predicted membrane protein [Function unknown]; Region: COG2259 1117943017798 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1117943017799 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1117943017800 active site 1117943017801 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 1117943017802 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1117943017803 Isochorismatase family; Region: Isochorismatase; pfam00857 1117943017804 catalytic triad [active] 1117943017805 dimer interface [polypeptide binding]; other site 1117943017806 conserved cis-peptide bond; other site 1117943017807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943017808 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1117943017809 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943017810 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943017811 Helix-turn-helix domain; Region: HTH_18; pfam12833 1117943017812 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943017813 Helix-turn-helix domain; Region: HTH_18; pfam12833 1117943017814 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943017815 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943017816 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943017817 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1117943017818 putative effector binding pocket; other site 1117943017819 dimerization interface [polypeptide binding]; other site 1117943017820 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1117943017821 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943017822 Zn binding site [ion binding]; other site 1117943017823 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1117943017824 Zn binding site [ion binding]; other site 1117943017825 Predicted esterase [General function prediction only]; Region: COG0400 1117943017826 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1117943017827 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943017828 active site 1117943017829 DNA binding site [nucleotide binding] 1117943017830 Int/Topo IB signature motif; other site 1117943017831 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1117943017832 putative catalytic residues [active] 1117943017833 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943017834 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943017835 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943017836 Helix-turn-helix domain; Region: HTH_28; pfam13518 1117943017837 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943017838 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943017839 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943017840 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943017841 SAM domain (Sterile alpha motif); Region: SAM_2; pfam07647 1117943017842 SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487 1117943017843 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943017844 cyclase homology domain; Region: CHD; cd07302 1117943017845 nucleotidyl binding site; other site 1117943017846 metal binding site [ion binding]; metal-binding site 1117943017847 dimer interface [polypeptide binding]; other site 1117943017848 Predicted ATPase [General function prediction only]; Region: COG3899 1117943017849 AAA ATPase domain; Region: AAA_16; pfam13191 1117943017850 Predicted ATPase [General function prediction only]; Region: COG3903 1117943017851 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1117943017852 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1117943017853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943017854 Walker A motif; other site 1117943017855 ATP binding site [chemical binding]; other site 1117943017856 Walker B motif; other site 1117943017857 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1117943017858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943017859 Integrase core domain; Region: rve; pfam00665 1117943017860 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943017861 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1117943017862 LysR family transcriptional regulator; Provisional; Region: PRK14997 1117943017863 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943017864 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1117943017865 putative effector binding pocket; other site 1117943017866 dimerization interface [polypeptide binding]; other site 1117943017867 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1117943017868 Serine hydrolase; Region: Ser_hydrolase; cl17834 1117943017869 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1117943017870 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1117943017871 substrate binding pocket [chemical binding]; other site 1117943017872 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1117943017873 homotrimer interaction site [polypeptide binding]; other site 1117943017874 putative active site [active] 1117943017875 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1117943017876 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1117943017877 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1117943017878 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1117943017879 active site 1117943017880 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1117943017881 dimer interface [polypeptide binding]; other site 1117943017882 substrate binding site [chemical binding]; other site 1117943017883 catalytic residues [active] 1117943017884 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943017885 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943017886 putative DNA binding site [nucleotide binding]; other site 1117943017887 putative Zn2+ binding site [ion binding]; other site 1117943017888 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943017889 homoserine dehydrogenase; Provisional; Region: PRK06270 1117943017890 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1117943017891 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1117943017892 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1117943017893 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 1117943017894 NAD(P) binding site [chemical binding]; other site 1117943017895 catalytic residues [active] 1117943017896 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1117943017897 Aspartase; Region: Aspartase; cd01357 1117943017898 active sites [active] 1117943017899 tetramer interface [polypeptide binding]; other site 1117943017900 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1117943017901 Phosphotransferase enzyme family; Region: APH; pfam01636 1117943017902 active site 1117943017903 substrate binding site [chemical binding]; other site 1117943017904 ATP binding site [chemical binding]; other site 1117943017905 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1117943017906 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1117943017907 putative DNA binding site [nucleotide binding]; other site 1117943017908 putative Zn2+ binding site [ion binding]; other site 1117943017909 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943017910 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1117943017911 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1117943017912 NAD binding site [chemical binding]; other site 1117943017913 catalytic residues [active] 1117943017914 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943017915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943017916 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943017917 dimerization interface [polypeptide binding]; other site 1117943017918 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 1117943017919 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1117943017920 dimer interface [polypeptide binding]; other site 1117943017921 active site 1117943017922 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1117943017923 substrate binding site [chemical binding]; other site 1117943017924 catalytic residue [active] 1117943017925 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1117943017926 homotrimer interaction site [polypeptide binding]; other site 1117943017927 putative active site [active] 1117943017928 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943017929 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1117943017930 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1117943017931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943017932 Coenzyme A binding pocket [chemical binding]; other site 1117943017933 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1117943017934 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1117943017935 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1117943017936 tetramerization interface [polypeptide binding]; other site 1117943017937 NAD(P) binding site [chemical binding]; other site 1117943017938 catalytic residues [active] 1117943017939 ectoine utilization protein EutC; Validated; Region: PRK08291 1117943017940 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1117943017941 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1117943017942 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1117943017943 tetramer interface [polypeptide binding]; other site 1117943017944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943017945 catalytic residue [active] 1117943017946 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1117943017947 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1117943017948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943017949 dimer interface [polypeptide binding]; other site 1117943017950 conserved gate region; other site 1117943017951 putative PBP binding loops; other site 1117943017952 ABC-ATPase subunit interface; other site 1117943017953 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1117943017954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943017955 dimer interface [polypeptide binding]; other site 1117943017956 conserved gate region; other site 1117943017957 putative PBP binding loops; other site 1117943017958 ABC-ATPase subunit interface; other site 1117943017959 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1117943017960 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943017961 substrate binding pocket [chemical binding]; other site 1117943017962 membrane-bound complex binding site; other site 1117943017963 hinge residues; other site 1117943017964 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1117943017965 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1117943017966 Walker A/P-loop; other site 1117943017967 ATP binding site [chemical binding]; other site 1117943017968 Q-loop/lid; other site 1117943017969 ABC transporter signature motif; other site 1117943017970 Walker B; other site 1117943017971 D-loop; other site 1117943017972 H-loop/switch region; other site 1117943017973 hypothetical protein; Provisional; Region: PRK07482 1117943017974 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1117943017975 inhibitor-cofactor binding pocket; inhibition site 1117943017976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943017977 catalytic residue [active] 1117943017978 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1117943017979 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1117943017980 putative DNA binding site [nucleotide binding]; other site 1117943017981 putative Zn2+ binding site [ion binding]; other site 1117943017982 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943017983 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1117943017984 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943017985 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943017986 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943017987 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943017988 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943017989 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943017990 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943017991 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943017992 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943017993 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1117943017994 putative DNA binding site [nucleotide binding]; other site 1117943017995 putative Zn2+ binding site [ion binding]; other site 1117943017996 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943017997 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943017998 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1117943017999 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1117943018000 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943018001 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1117943018002 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1117943018003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943018004 dimer interface [polypeptide binding]; other site 1117943018005 conserved gate region; other site 1117943018006 putative PBP binding loops; other site 1117943018007 ABC-ATPase subunit interface; other site 1117943018008 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1117943018009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943018010 dimer interface [polypeptide binding]; other site 1117943018011 conserved gate region; other site 1117943018012 putative PBP binding loops; other site 1117943018013 ABC-ATPase subunit interface; other site 1117943018014 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1117943018015 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 1117943018016 peptide binding site [polypeptide binding]; other site 1117943018017 dimer interface [polypeptide binding]; other site 1117943018018 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1117943018019 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943018020 Walker A/P-loop; other site 1117943018021 ATP binding site [chemical binding]; other site 1117943018022 Q-loop/lid; other site 1117943018023 ABC transporter signature motif; other site 1117943018024 Walker B; other site 1117943018025 D-loop; other site 1117943018026 H-loop/switch region; other site 1117943018027 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1117943018028 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943018029 Walker A/P-loop; other site 1117943018030 ATP binding site [chemical binding]; other site 1117943018031 Q-loop/lid; other site 1117943018032 ABC transporter signature motif; other site 1117943018033 Walker B; other site 1117943018034 D-loop; other site 1117943018035 H-loop/switch region; other site 1117943018036 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1117943018037 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1117943018038 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943018039 DNA-binding site [nucleotide binding]; DNA binding site 1117943018040 FCD domain; Region: FCD; pfam07729 1117943018041 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1117943018042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943018043 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943018044 dimerization interface [polypeptide binding]; other site 1117943018045 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1117943018046 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1117943018047 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1117943018048 phosphate binding site [ion binding]; other site 1117943018049 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1117943018050 dimer interface [polypeptide binding]; other site 1117943018051 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1117943018052 putative CheW interface [polypeptide binding]; other site 1117943018053 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1117943018054 dimerization interface [polypeptide binding]; other site 1117943018055 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1117943018056 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 1117943018057 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1117943018058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943018059 Coenzyme A binding pocket [chemical binding]; other site 1117943018060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1117943018061 hypothetical protein; Provisional; Region: PRK05965 1117943018062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1117943018063 Coenzyme A binding pocket [chemical binding]; other site 1117943018064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1117943018065 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1117943018066 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1117943018067 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1117943018068 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1117943018069 tetramer interface [polypeptide binding]; other site 1117943018070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943018071 catalytic residue [active] 1117943018072 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1117943018073 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 1117943018074 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1117943018075 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1117943018076 active site 1117943018077 ATP binding site [chemical binding]; other site 1117943018078 substrate binding site [chemical binding]; other site 1117943018079 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1117943018080 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1117943018081 inhibitor-cofactor binding pocket; inhibition site 1117943018082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943018083 catalytic residue [active] 1117943018084 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943018085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943018086 DNA-binding site [nucleotide binding]; DNA binding site 1117943018087 FCD domain; Region: FCD; pfam07729 1117943018088 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1117943018089 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1117943018090 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 1117943018091 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943018092 metal binding site [ion binding]; metal-binding site 1117943018093 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943018094 DNA binding site [nucleotide binding] 1117943018095 Int/Topo IB signature motif; other site 1117943018096 active site 1117943018097 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1117943018098 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1117943018099 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1117943018100 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1117943018101 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943018102 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1117943018103 succinyl-CoA synthetase, alpha subunit; Region: sucCoAalpha; TIGR01019 1117943018104 CoA binding domain; Region: CoA_binding; pfam02629 1117943018105 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1117943018106 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1117943018107 oxalacetate binding site [chemical binding]; other site 1117943018108 citrylCoA binding site [chemical binding]; other site 1117943018109 coenzyme A binding site [chemical binding]; other site 1117943018110 catalytic triad [active] 1117943018111 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1117943018112 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 1117943018113 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1117943018114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943018115 dimer interface [polypeptide binding]; other site 1117943018116 conserved gate region; other site 1117943018117 putative PBP binding loops; other site 1117943018118 ABC-ATPase subunit interface; other site 1117943018119 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1117943018120 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1117943018121 Walker A/P-loop; other site 1117943018122 ATP binding site [chemical binding]; other site 1117943018123 Q-loop/lid; other site 1117943018124 ABC transporter signature motif; other site 1117943018125 Walker B; other site 1117943018126 D-loop; other site 1117943018127 H-loop/switch region; other site 1117943018128 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1117943018129 NMT1-like family; Region: NMT1_2; pfam13379 1117943018130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1117943018131 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943018132 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943018133 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1117943018134 putative dimerization interface [polypeptide binding]; other site 1117943018135 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943018136 cyclase homology domain; Region: CHD; cd07302 1117943018137 nucleotidyl binding site; other site 1117943018138 metal binding site [ion binding]; metal-binding site 1117943018139 dimer interface [polypeptide binding]; other site 1117943018140 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943018141 TPR repeat; Region: TPR_11; pfam13414 1117943018142 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943018143 TPR motif; other site 1117943018144 binding surface 1117943018145 TPR repeat; Region: TPR_11; pfam13414 1117943018146 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943018147 TPR motif; other site 1117943018148 binding surface 1117943018149 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1117943018150 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1117943018151 Isochorismatase family; Region: Isochorismatase; pfam00857 1117943018152 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1117943018153 catalytic triad [active] 1117943018154 dimer interface [polypeptide binding]; other site 1117943018155 conserved cis-peptide bond; other site 1117943018156 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943018157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943018158 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1117943018159 putative effector binding pocket; other site 1117943018160 dimerization interface [polypeptide binding]; other site 1117943018161 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943018162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943018163 sequence-specific DNA binding site [nucleotide binding]; other site 1117943018164 salt bridge; other site 1117943018165 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1117943018166 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1117943018167 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943018168 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943018169 non-specific DNA binding site [nucleotide binding]; other site 1117943018170 salt bridge; other site 1117943018171 sequence-specific DNA binding site [nucleotide binding]; other site 1117943018172 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1117943018173 ABC transporter signature motif; other site 1117943018174 Walker B; other site 1117943018175 D-loop; other site 1117943018176 Uncharacterized conserved protein [Function unknown]; Region: COG5397 1117943018177 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 1117943018178 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1117943018179 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1117943018180 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1117943018181 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1117943018182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943018183 dimer interface [polypeptide binding]; other site 1117943018184 conserved gate region; other site 1117943018185 putative PBP binding loops; other site 1117943018186 ABC-ATPase subunit interface; other site 1117943018187 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1117943018188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943018189 dimer interface [polypeptide binding]; other site 1117943018190 conserved gate region; other site 1117943018191 putative PBP binding loops; other site 1117943018192 ABC-ATPase subunit interface; other site 1117943018193 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1117943018194 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1117943018195 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1117943018196 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943018197 Walker A/P-loop; other site 1117943018198 ATP binding site [chemical binding]; other site 1117943018199 Q-loop/lid; other site 1117943018200 ABC transporter signature motif; other site 1117943018201 Walker B; other site 1117943018202 D-loop; other site 1117943018203 H-loop/switch region; other site 1117943018204 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1117943018205 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1117943018206 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1117943018207 Walker A/P-loop; other site 1117943018208 ATP binding site [chemical binding]; other site 1117943018209 Q-loop/lid; other site 1117943018210 ABC transporter signature motif; other site 1117943018211 Walker B; other site 1117943018212 D-loop; other site 1117943018213 H-loop/switch region; other site 1117943018214 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1117943018215 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1117943018216 active site 1117943018217 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943018218 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943018219 DNA-binding site [nucleotide binding]; DNA binding site 1117943018220 FCD domain; Region: FCD; pfam07729 1117943018221 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1117943018222 EamA-like transporter family; Region: EamA; pfam00892 1117943018223 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1117943018224 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 1117943018225 active site 1117943018226 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943018227 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943018228 DNA-binding site [nucleotide binding]; DNA binding site 1117943018229 FCD domain; Region: FCD; pfam07729 1117943018230 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1117943018231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943018232 Walker A/P-loop; other site 1117943018233 ATP binding site [chemical binding]; other site 1117943018234 Q-loop/lid; other site 1117943018235 ABC transporter signature motif; other site 1117943018236 Walker B; other site 1117943018237 D-loop; other site 1117943018238 H-loop/switch region; other site 1117943018239 TOBE domain; Region: TOBE_2; pfam08402 1117943018240 TOBE domain; Region: TOBE_2; pfam08402 1117943018241 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 1117943018242 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1117943018243 active site 1117943018244 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1117943018245 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1117943018246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943018247 ABC-ATPase subunit interface; other site 1117943018248 putative PBP binding loops; other site 1117943018249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943018250 dimer interface [polypeptide binding]; other site 1117943018251 conserved gate region; other site 1117943018252 putative PBP binding loops; other site 1117943018253 ABC-ATPase subunit interface; other site 1117943018254 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1117943018255 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1117943018256 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1117943018257 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 1117943018258 active site 1117943018259 allantoinase; Provisional; Region: PRK06189 1117943018260 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1117943018261 active site 1117943018262 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 1117943018263 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1117943018264 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 1117943018265 Uncharacterized conserved protein [Function unknown]; Region: COG5588 1117943018266 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1117943018267 oligomeric interface; other site 1117943018268 putative active site [active] 1117943018269 homodimer interface [polypeptide binding]; other site 1117943018270 prevent-host-death family protein; Region: phd_fam; TIGR01552 1117943018271 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1117943018272 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1117943018273 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1117943018274 homotrimer interaction site [polypeptide binding]; other site 1117943018275 putative active site [active] 1117943018276 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1117943018277 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943018278 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1117943018279 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1117943018280 oligomer interface [polypeptide binding]; other site 1117943018281 metal binding site [ion binding]; metal-binding site 1117943018282 metal binding site [ion binding]; metal-binding site 1117943018283 putative Cl binding site [ion binding]; other site 1117943018284 basic sphincter; other site 1117943018285 hydrophobic gate; other site 1117943018286 periplasmic entrance; other site 1117943018287 K+ potassium transporter; Region: K_trans; cl15781 1117943018288 Cupin domain; Region: Cupin_2; pfam07883 1117943018289 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1117943018290 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1117943018291 NAD(P) binding site [chemical binding]; other site 1117943018292 catalytic residues [active] 1117943018293 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1117943018294 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1117943018295 Metal-binding active site; metal-binding site 1117943018296 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1117943018297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1117943018298 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1117943018299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1117943018300 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1117943018301 tartrate dehydrogenase; Region: TTC; TIGR02089 1117943018302 Predicted transcriptional regulators [Transcription]; Region: COG1725 1117943018303 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943018304 DNA-binding site [nucleotide binding]; DNA binding site 1117943018305 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943018306 FCD domain; Region: FCD; pfam07729 1117943018307 Fic family protein [Function unknown]; Region: COG3177 1117943018308 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 1117943018309 Fic/DOC family; Region: Fic; pfam02661 1117943018310 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 1117943018311 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1117943018312 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1117943018313 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1117943018314 oligomeric interface; other site 1117943018315 putative active site [active] 1117943018316 homodimer interface [polypeptide binding]; other site 1117943018317 prevent-host-death family protein; Region: phd_fam; TIGR01552 1117943018318 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1117943018319 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943018320 cyclase homology domain; Region: CHD; cd07302 1117943018321 nucleotidyl binding site; other site 1117943018322 metal binding site [ion binding]; metal-binding site 1117943018323 dimer interface [polypeptide binding]; other site 1117943018324 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943018325 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1117943018326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943018327 TPR motif; other site 1117943018328 binding surface 1117943018329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943018330 TPR motif; other site 1117943018331 binding surface 1117943018332 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1117943018333 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1117943018334 putative active site [active] 1117943018335 homotetrameric interface [polypeptide binding]; other site 1117943018336 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943018337 active site 1117943018338 DNA binding site [nucleotide binding] 1117943018339 Int/Topo IB signature motif; other site 1117943018340 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1117943018341 DNA-binding site [nucleotide binding]; DNA binding site 1117943018342 RNA-binding motif; other site 1117943018343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943018344 putative PBP binding loops; other site 1117943018345 dimer interface [polypeptide binding]; other site 1117943018346 ABC-ATPase subunit interface; other site 1117943018347 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1117943018348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943018349 Walker A/P-loop; other site 1117943018350 ATP binding site [chemical binding]; other site 1117943018351 Q-loop/lid; other site 1117943018352 ABC transporter signature motif; other site 1117943018353 Walker B; other site 1117943018354 D-loop; other site 1117943018355 H-loop/switch region; other site 1117943018356 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943018357 cyclase homology domain; Region: CHD; cd07302 1117943018358 nucleotidyl binding site; other site 1117943018359 metal binding site [ion binding]; metal-binding site 1117943018360 dimer interface [polypeptide binding]; other site 1117943018361 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943018362 TPR repeat; Region: TPR_11; pfam13414 1117943018363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943018364 TPR motif; other site 1117943018365 binding surface 1117943018366 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943018367 salt bridge; other site 1117943018368 non-specific DNA binding site [nucleotide binding]; other site 1117943018369 sequence-specific DNA binding site [nucleotide binding]; other site 1117943018370 Helix-turn-helix domain; Region: HTH_17; cl17695 1117943018371 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1117943018372 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1117943018373 NAD binding site [chemical binding]; other site 1117943018374 homodimer interface [polypeptide binding]; other site 1117943018375 homotetramer interface [polypeptide binding]; other site 1117943018376 active site 1117943018377 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943018378 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943018379 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1117943018380 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1117943018381 DNA binding site [nucleotide binding] 1117943018382 domain linker motif; other site 1117943018383 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1117943018384 dimerization interface [polypeptide binding]; other site 1117943018385 ligand binding site [chemical binding]; other site 1117943018386 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943018387 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943018388 TM-ABC transporter signature motif; other site 1117943018389 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1117943018390 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1117943018391 TM-ABC transporter signature motif; other site 1117943018392 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1117943018393 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1117943018394 Walker A/P-loop; other site 1117943018395 ATP binding site [chemical binding]; other site 1117943018396 Q-loop/lid; other site 1117943018397 ABC transporter signature motif; other site 1117943018398 Walker B; other site 1117943018399 D-loop; other site 1117943018400 H-loop/switch region; other site 1117943018401 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1117943018402 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 1117943018403 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1117943018404 putative ligand binding site [chemical binding]; other site 1117943018405 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943018406 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943018407 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1117943018408 putative effector binding pocket; other site 1117943018409 dimerization interface [polypeptide binding]; other site 1117943018410 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1117943018411 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1117943018412 NADP binding site [chemical binding]; other site 1117943018413 dimer interface [polypeptide binding]; other site 1117943018414 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1117943018415 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1117943018416 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1117943018417 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1117943018418 Walker A/P-loop; other site 1117943018419 ATP binding site [chemical binding]; other site 1117943018420 Q-loop/lid; other site 1117943018421 ABC transporter signature motif; other site 1117943018422 Walker B; other site 1117943018423 D-loop; other site 1117943018424 H-loop/switch region; other site 1117943018425 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1117943018426 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1117943018427 ABC-ATPase subunit interface; other site 1117943018428 dimer interface [polypeptide binding]; other site 1117943018429 putative PBP binding regions; other site 1117943018430 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1117943018431 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1117943018432 putative ligand binding residues [chemical binding]; other site 1117943018433 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1117943018434 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1117943018435 dimer interface [polypeptide binding]; other site 1117943018436 putative radical transfer pathway; other site 1117943018437 diiron center [ion binding]; other site 1117943018438 tyrosyl radical; other site 1117943018439 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1117943018440 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1117943018441 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1117943018442 active site 1117943018443 dimer interface [polypeptide binding]; other site 1117943018444 catalytic residues [active] 1117943018445 effector binding site; other site 1117943018446 R2 peptide binding site; other site 1117943018447 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1117943018448 catalytic residues [active] 1117943018449 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1117943018450 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1117943018451 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1117943018452 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1117943018453 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1117943018454 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1117943018455 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1117943018456 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1117943018457 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1117943018458 catalytic loop [active] 1117943018459 iron binding site [ion binding]; other site 1117943018460 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1117943018461 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 1117943018462 putative hydrophobic ligand binding site [chemical binding]; other site 1117943018463 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1117943018464 NMT1/THI5 like; Region: NMT1; pfam09084 1117943018465 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1117943018466 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1117943018467 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1117943018468 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1117943018469 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1117943018470 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1117943018471 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1117943018472 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1117943018473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943018474 DNA-binding site [nucleotide binding]; DNA binding site 1117943018475 FCD domain; Region: FCD; pfam07729 1117943018476 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1117943018477 Flavoprotein; Region: Flavoprotein; pfam02441 1117943018478 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 1117943018479 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1117943018480 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 1117943018481 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1117943018482 PYR/PP interface [polypeptide binding]; other site 1117943018483 dimer interface [polypeptide binding]; other site 1117943018484 TPP binding site [chemical binding]; other site 1117943018485 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1117943018486 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1117943018487 TPP-binding site [chemical binding]; other site 1117943018488 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1117943018489 active site 1117943018490 metal binding site [ion binding]; metal-binding site 1117943018491 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1117943018492 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 1117943018493 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943018494 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943018495 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1117943018496 substrate binding pocket [chemical binding]; other site 1117943018497 dimerization interface [polypeptide binding]; other site 1117943018498 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1117943018499 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1117943018500 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1117943018501 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1117943018502 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1117943018503 Isochorismatase family; Region: Isochorismatase; pfam00857 1117943018504 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1117943018505 catalytic triad [active] 1117943018506 conserved cis-peptide bond; other site 1117943018507 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1117943018508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943018509 dimer interface [polypeptide binding]; other site 1117943018510 conserved gate region; other site 1117943018511 putative PBP binding loops; other site 1117943018512 ABC-ATPase subunit interface; other site 1117943018513 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1117943018514 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1117943018515 Walker A/P-loop; other site 1117943018516 ATP binding site [chemical binding]; other site 1117943018517 Q-loop/lid; other site 1117943018518 ABC transporter signature motif; other site 1117943018519 Walker B; other site 1117943018520 D-loop; other site 1117943018521 H-loop/switch region; other site 1117943018522 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1117943018523 NMT1/THI5 like; Region: NMT1; pfam09084 1117943018524 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1117943018525 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1117943018526 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1117943018527 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1117943018528 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1117943018529 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1117943018530 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 1117943018531 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943018532 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943018533 dimerization interface [polypeptide binding]; other site 1117943018534 Predicted flavoprotein [General function prediction only]; Region: COG0431 1117943018535 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1117943018536 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 1117943018537 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1117943018538 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1117943018539 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1117943018540 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1117943018541 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1117943018542 FMN binding site [chemical binding]; other site 1117943018543 active site 1117943018544 substrate binding site [chemical binding]; other site 1117943018545 catalytic residue [active] 1117943018546 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943018547 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943018548 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1117943018549 putative effector binding pocket; other site 1117943018550 dimerization interface [polypeptide binding]; other site 1117943018551 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1117943018552 homotrimer interaction site [polypeptide binding]; other site 1117943018553 putative active site [active] 1117943018554 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1117943018555 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943018556 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1117943018557 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 1117943018558 putative metal binding site [ion binding]; other site 1117943018559 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1117943018560 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 1117943018561 Helix-turn-helix domain; Region: HTH_18; pfam12833 1117943018562 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943018563 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1117943018564 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1117943018565 carboxyltransferase (CT) interaction site; other site 1117943018566 biotinylation site [posttranslational modification]; other site 1117943018567 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1117943018568 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1117943018569 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1117943018570 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1117943018571 oxaloacetate decarboxylase alpha subunit; Region: oadA; TIGR01108 1117943018572 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1117943018573 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1117943018574 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1117943018575 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1117943018576 putative active site [active] 1117943018577 aspartate aminotransferase; Provisional; Region: PRK05764 1117943018578 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943018579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943018580 homodimer interface [polypeptide binding]; other site 1117943018581 catalytic residue [active] 1117943018582 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1117943018583 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943018584 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1117943018585 putative dimerization interface [polypeptide binding]; other site 1117943018586 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1117943018587 classical (c) SDRs; Region: SDR_c; cd05233 1117943018588 NAD(P) binding site [chemical binding]; other site 1117943018589 active site 1117943018590 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1117943018591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943018592 dimer interface [polypeptide binding]; other site 1117943018593 conserved gate region; other site 1117943018594 putative PBP binding loops; other site 1117943018595 ABC-ATPase subunit interface; other site 1117943018596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943018597 dimer interface [polypeptide binding]; other site 1117943018598 conserved gate region; other site 1117943018599 putative PBP binding loops; other site 1117943018600 ABC-ATPase subunit interface; other site 1117943018601 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1117943018602 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1117943018603 Walker A/P-loop; other site 1117943018604 ATP binding site [chemical binding]; other site 1117943018605 Q-loop/lid; other site 1117943018606 ABC transporter signature motif; other site 1117943018607 Walker B; other site 1117943018608 D-loop; other site 1117943018609 H-loop/switch region; other site 1117943018610 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1117943018611 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1117943018612 substrate binding pocket [chemical binding]; other site 1117943018613 membrane-bound complex binding site; other site 1117943018614 hinge residues; other site 1117943018615 hypothetical protein; Validated; Region: PRK06201 1117943018616 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1117943018617 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1117943018618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943018619 S-adenosylmethionine binding site [chemical binding]; other site 1117943018620 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1117943018621 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1117943018622 conserved cys residue [active] 1117943018623 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1117943018624 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943018625 cyclase homology domain; Region: CHD; cd07302 1117943018626 nucleotidyl binding site; other site 1117943018627 metal binding site [ion binding]; metal-binding site 1117943018628 dimer interface [polypeptide binding]; other site 1117943018629 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943018630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943018631 TPR motif; other site 1117943018632 TPR repeat; Region: TPR_11; pfam13414 1117943018633 binding surface 1117943018634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943018635 binding surface 1117943018636 TPR motif; other site 1117943018637 DinB family; Region: DinB; cl17821 1117943018638 DinB superfamily; Region: DinB_2; pfam12867 1117943018639 Dienelactone hydrolase family; Region: DLH; pfam01738 1117943018640 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1117943018641 GAF domain; Region: GAF; pfam01590 1117943018642 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1117943018643 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 1117943018644 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1117943018645 5-oxoprolinase; Region: PLN02666 1117943018646 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1117943018647 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1117943018648 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1117943018649 MarR family; Region: MarR_2; cl17246 1117943018650 Ion channel; Region: Ion_trans_2; pfam07885 1117943018651 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1117943018652 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1117943018653 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1117943018654 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1117943018655 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1117943018656 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1117943018657 RNA binding surface [nucleotide binding]; other site 1117943018658 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1117943018659 active site 1117943018660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1117943018661 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1117943018662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1117943018663 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1117943018664 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1117943018665 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1117943018666 cyclase homology domain; Region: CHD; cd07302 1117943018667 nucleotidyl binding site; other site 1117943018668 metal binding site [ion binding]; metal-binding site 1117943018669 dimer interface [polypeptide binding]; other site 1117943018670 Predicted integral membrane protein [Function unknown]; Region: COG5616 1117943018671 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943018672 binding surface 1117943018673 TPR motif; other site 1117943018674 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1117943018675 oligomeric interface; other site 1117943018676 putative active site [active] 1117943018677 homodimer interface [polypeptide binding]; other site 1117943018678 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1117943018679 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1117943018680 putative DNA binding site [nucleotide binding]; other site 1117943018681 putative Zn2+ binding site [ion binding]; other site 1117943018682 AsnC family; Region: AsnC_trans_reg; pfam01037 1117943018683 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1117943018684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943018685 putative substrate translocation pore; other site 1117943018686 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1117943018687 metal ion-dependent adhesion site (MIDAS); other site 1117943018688 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1117943018689 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1117943018690 tetramer interface [polypeptide binding]; other site 1117943018691 active site 1117943018692 Mg2+/Mn2+ binding site [ion binding]; other site 1117943018693 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1117943018694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1117943018695 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1117943018696 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1117943018697 DctM-like transporters; Region: DctM; pfam06808 1117943018698 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1117943018699 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1117943018700 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 1117943018701 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1117943018702 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1117943018703 shikimate binding site; other site 1117943018704 NAD(P) binding site [chemical binding]; other site 1117943018705 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1117943018706 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1117943018707 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1117943018708 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1117943018709 active site 1117943018710 metal binding site [ion binding]; metal-binding site 1117943018711 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 1117943018712 ligand binding site; other site 1117943018713 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 1117943018714 Cupin domain; Region: Cupin_2; cl17218 1117943018715 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1117943018716 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1117943018717 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1117943018718 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1117943018719 inhibitor site; inhibition site 1117943018720 active site 1117943018721 dimer interface [polypeptide binding]; other site 1117943018722 catalytic residue [active] 1117943018723 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1117943018724 Lysine efflux permease [General function prediction only]; Region: COG1279 1117943018725 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1117943018726 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943018727 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943018728 dimerization interface [polypeptide binding]; other site 1117943018729 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1117943018730 dimer interface [polypeptide binding]; other site 1117943018731 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1117943018732 putative active site [active] 1117943018733 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1117943018734 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1117943018735 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1117943018736 elongation factor G; Reviewed; Region: PRK12740 1117943018737 G1 box; other site 1117943018738 putative GEF interaction site [polypeptide binding]; other site 1117943018739 GTP/Mg2+ binding site [chemical binding]; other site 1117943018740 Switch I region; other site 1117943018741 G2 box; other site 1117943018742 G3 box; other site 1117943018743 Switch II region; other site 1117943018744 G4 box; other site 1117943018745 G5 box; other site 1117943018746 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1117943018747 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1117943018748 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1117943018749 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1117943018750 DNA-binding site [nucleotide binding]; DNA binding site 1117943018751 UTRA domain; Region: UTRA; pfam07702 1117943018752 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1117943018753 ParA-like protein; Provisional; Region: PHA02518 1117943018754 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1117943018755 P-loop; other site 1117943018756 Magnesium ion binding site [ion binding]; other site 1117943018757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943018758 non-specific DNA binding site [nucleotide binding]; other site 1117943018759 salt bridge; other site 1117943018760 sequence-specific DNA binding site [nucleotide binding]; other site 1117943018761 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 1117943018762 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1117943018763 Walker A motif; other site 1117943018764 ATP binding site [chemical binding]; other site 1117943018765 Walker B motif; other site 1117943018766 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 1117943018767 putative metal binding site [ion binding]; other site 1117943018768 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1117943018769 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 1117943018770 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 1117943018771 MobA/MobL family; Region: MobA_MobL; pfam03389 1117943018772 AAA domain; Region: AAA_30; pfam13604 1117943018773 Family description; Region: UvrD_C_2; pfam13538 1117943018774 Nmi/IFP 35 domain (NID); Region: NID; pfam07292 1117943018775 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1117943018776 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1117943018777 catalytic residues [active] 1117943018778 catalytic nucleophile [active] 1117943018779 Presynaptic Site I dimer interface [polypeptide binding]; other site 1117943018780 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1117943018781 Synaptic Flat tetramer interface [polypeptide binding]; other site 1117943018782 Synaptic Site I dimer interface [polypeptide binding]; other site 1117943018783 DNA binding site [nucleotide binding] 1117943018784 HTH domain; Region: HTH_22; pfam13309 1117943018785 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1117943018786 putative active site [active] 1117943018787 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943018788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943018789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943018790 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943018791 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943018792 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1117943018793 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1117943018794 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943018795 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943018796 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943018797 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943018798 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943018799 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943018800 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1117943018801 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1117943018802 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 1117943018803 catalytic residues [active] 1117943018804 catalytic nucleophile [active] 1117943018805 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; cl17623 1117943018806 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1117943018807 Integrase core domain; Region: rve_3; cl15866 1117943018808 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943018809 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943018810 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1117943018811 HTH-like domain; Region: HTH_21; pfam13276 1117943018812 Integrase core domain; Region: rve; pfam00665 1117943018813 Integrase core domain; Region: rve_3; pfam13683 1117943018814 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1117943018815 metal binding triad [ion binding]; metal-binding site 1117943018816 Y-family of DNA polymerases; Region: PolY; cl12025 1117943018817 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1117943018818 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 1117943018819 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 1117943018820 Zn binding site [ion binding]; other site 1117943018821 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1117943018822 Peptidase family M28; Region: Peptidase_M28; pfam04389 1117943018823 metal binding site [ion binding]; metal-binding site 1117943018824 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1117943018825 catalytic core [active] 1117943018826 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1117943018827 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1117943018828 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1117943018829 active site 1117943018830 Zn binding site [ion binding]; other site 1117943018831 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1117943018832 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1117943018833 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1117943018834 dinuclear metal binding motif [ion binding]; other site 1117943018835 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943018836 Transposase; Region: HTH_Tnp_1; pfam01527 1117943018837 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1117943018838 HTH-like domain; Region: HTH_21; pfam13276 1117943018839 Integrase core domain; Region: rve; pfam00665 1117943018840 Integrase core domain; Region: rve_3; pfam13683 1117943018841 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 1117943018842 Part of AAA domain; Region: AAA_19; pfam13245 1117943018843 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1117943018844 AAA domain; Region: AAA_30; pfam13604 1117943018845 AAA domain; Region: AAA_12; pfam13087 1117943018846 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1117943018847 putative active site [active] 1117943018848 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 1117943018849 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1117943018850 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1117943018851 active site 1117943018852 metal binding site [ion binding]; metal-binding site 1117943018853 DNA binding site [nucleotide binding] 1117943018854 AAA domain; Region: AAA_23; pfam13476 1117943018855 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1117943018856 short chain dehydrogenase; Provisional; Region: PRK06180 1117943018857 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1117943018858 NADP binding site [chemical binding]; other site 1117943018859 active site 1117943018860 steroid binding site; other site 1117943018861 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943018862 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943018863 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943018864 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943018865 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1117943018866 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1117943018867 catalytic residues [active] 1117943018868 catalytic nucleophile [active] 1117943018869 Presynaptic Site I dimer interface [polypeptide binding]; other site 1117943018870 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1117943018871 Synaptic Flat tetramer interface [polypeptide binding]; other site 1117943018872 Synaptic Site I dimer interface [polypeptide binding]; other site 1117943018873 DNA binding site [nucleotide binding] 1117943018874 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1117943018875 DNA-binding interface [nucleotide binding]; DNA binding site 1117943018876 Abi-like protein; Region: Abi_2; pfam07751 1117943018877 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 1117943018878 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1117943018879 Walker A/P-loop; other site 1117943018880 ATP binding site [chemical binding]; other site 1117943018882 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943018883 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943018884 Winged helix-turn helix; Region: HTH_33; pfam13592 1117943018885 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943018886 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943018887 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943018888 Integrase core domain; Region: rve; cl01316 1117943018889 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1117943018890 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1117943018891 Sulfatase; Region: Sulfatase; pfam00884 1117943018892 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 1117943018893 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1117943018894 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1117943018895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943018896 active site 1117943018897 phosphorylation site [posttranslational modification] 1117943018898 intermolecular recognition site; other site 1117943018899 dimerization interface [polypeptide binding]; other site 1117943018900 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943018901 DNA binding site [nucleotide binding] 1117943018902 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1117943018903 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943018904 non-specific DNA binding site [nucleotide binding]; other site 1117943018905 salt bridge; other site 1117943018906 sequence-specific DNA binding site [nucleotide binding]; other site 1117943018907 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1117943018908 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1117943018909 Integrase core domain; Region: rve; cl01316 1117943018910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1117943018911 Integrase core domain; Region: rve; pfam00665 1117943018912 Restriction endonuclease; Region: Mrr_cat; pfam04471 1117943018913 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1117943018914 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943018915 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943018916 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943018917 Winged helix-turn helix; Region: HTH_33; pfam13592 1117943018918 Integrase core domain; Region: rve; cl01316 1117943018919 Alpha-helical domain of GINS complex proteins; Sld5, Psf1, Psf2 and Psf3; Region: GINS_A; cl17012 1117943018920 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943018921 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943018922 Winged helix-turn helix; Region: HTH_33; pfam13592 1117943018923 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943018924 Helix-turn-helix domains; Region: HTH; cl00088 1117943018925 putative transposase OrfB; Reviewed; Region: PHA02517 1117943018926 HTH-like domain; Region: HTH_21; pfam13276 1117943018927 Integrase core domain; Region: rve; pfam00665 1117943018928 Integrase core domain; Region: rve_3; pfam13683 1117943018929 Helix-turn-helix domain; Region: HTH_28; pfam13518 1117943018930 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943018931 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943018932 Helix-turn-helix domain; Region: HTH_28; pfam13518 1117943018933 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943018934 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943018935 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1117943018936 Helix-turn-helix domain; Region: HTH_38; pfam13936 1117943018937 Integrase core domain; Region: rve; pfam00665 1117943018938 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 1117943018939 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1117943018940 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943018941 Integrase core domain; Region: rve; cl01316 1117943018942 Predicted transcriptional regulator [Transcription]; Region: COG4957 1117943018943 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 1117943018944 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943018945 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943018946 sequence-specific DNA binding site [nucleotide binding]; other site 1117943018947 salt bridge; other site 1117943018948 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943018949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943018950 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943018951 dimerization interface [polypeptide binding]; other site 1117943018952 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1117943018953 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1117943018954 Substrate binding site; other site 1117943018955 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1117943018956 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 1117943018957 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 1117943018958 active site 1117943018959 substrate binding site [chemical binding]; other site 1117943018960 metal binding site [ion binding]; metal-binding site 1117943018961 Nodulation protein Z (NodZ); Region: NodZ; pfam05830 1117943018962 GDP-Fucose binding site [chemical binding]; other site 1117943018963 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 1117943018964 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1117943018965 NADP-binding site; other site 1117943018966 homotetramer interface [polypeptide binding]; other site 1117943018967 substrate binding site [chemical binding]; other site 1117943018968 homodimer interface [polypeptide binding]; other site 1117943018969 active site 1117943018970 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1117943018971 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1117943018972 NADP binding site [chemical binding]; other site 1117943018973 active site 1117943018974 putative substrate binding site [chemical binding]; other site 1117943018975 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943018976 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943018977 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943018978 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943018979 SnoaL-like domain; Region: SnoaL_2; pfam12680 1117943018980 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1117943018981 active site lid residues [active] 1117943018982 substrate binding pocket [chemical binding]; other site 1117943018983 catalytic residues [active] 1117943018984 substrate-Mg2+ binding site; other site 1117943018985 aspartate-rich region 1; other site 1117943018986 aspartate-rich region 2; other site 1117943018987 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1117943018988 active site lid residues [active] 1117943018989 substrate binding pocket [chemical binding]; other site 1117943018990 catalytic residues [active] 1117943018991 substrate-Mg2+ binding site; other site 1117943018992 aspartate-rich region 1; other site 1117943018993 aspartate-rich region 2; other site 1117943018994 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 1117943018995 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1117943018996 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1117943018997 Active site cavity [active] 1117943018998 catalytic acid [active] 1117943018999 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1117943019000 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943019001 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943019002 dimerization interface [polypeptide binding]; other site 1117943019003 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; pfam03543 1117943019004 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1117943019005 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943019006 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943019007 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943019008 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943019009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943019010 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943019011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943019012 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943019013 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943019014 binding surface 1117943019015 TPR motif; other site 1117943019016 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1117943019017 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 1117943019018 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 1117943019019 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1117943019020 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; pfam01312 1117943019021 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1117943019022 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 1117943019023 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 1117943019024 type III secretion system protein YscR; Provisional; Region: PRK12797 1117943019025 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 1117943019026 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1117943019027 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 1117943019028 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1117943019029 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1117943019030 Walker A motif; other site 1117943019031 ATP binding site [chemical binding]; other site 1117943019032 Walker B motif; other site 1117943019033 Nodulation protein NolV; Region: NolV; pfam06635 1117943019034 Flagellar assembly protein FliH; Region: FliH; pfam02108 1117943019035 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 1117943019036 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1117943019037 NolX protein; Region: NolX; pfam05819 1117943019038 ParB-like nuclease domain; Region: ParBc; cl02129 1117943019039 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1117943019040 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1117943019041 catalytic residue [active] 1117943019042 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1117943019043 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1117943019044 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1117943019045 dimer interface [polypeptide binding]; other site 1117943019046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943019047 catalytic residue [active] 1117943019048 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1117943019049 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1117943019050 IucA / IucC family; Region: IucA_IucC; pfam04183 1117943019051 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1117943019052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943019053 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1117943019054 putative substrate translocation pore; other site 1117943019055 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943019056 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943019057 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943019058 pilus (Caulobacter type) biogenesis lipoprotein CpaD; Region: pilus_cpaD; TIGR02522 1117943019059 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 1117943019060 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1117943019061 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1117943019062 BON domain; Region: BON; pfam04972 1117943019063 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1117943019064 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1117943019065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943019066 active site 1117943019067 phosphorylation site [posttranslational modification] 1117943019068 intermolecular recognition site; other site 1117943019069 dimerization interface [polypeptide binding]; other site 1117943019070 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943019071 DNA binding site [nucleotide binding] 1117943019072 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943019073 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943019074 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 1117943019075 putative substrate binding pocket [chemical binding]; other site 1117943019076 putative dimerization interface [polypeptide binding]; other site 1117943019077 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943019078 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 1117943019079 HTH-like domain; Region: HTH_21; pfam13276 1117943019080 Integrase core domain; Region: rve; pfam00665 1117943019081 Integrase core domain; Region: rve_3; pfam13683 1117943019082 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943019083 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1117943019084 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1117943019085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943019086 Walker A motif; other site 1117943019087 ATP binding site [chemical binding]; other site 1117943019088 Walker B motif; other site 1117943019089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943019090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943019091 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1117943019092 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943019093 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943019094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943019095 Protein of unknown function, DUF269; Region: DUF269; pfam03270 1117943019096 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 1117943019097 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 1117943019098 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 1117943019099 MoFe protein beta/alpha subunit interactions; other site 1117943019100 Beta subunit P cluster binding residues; other site 1117943019101 MoFe protein beta subunit/Fe protein contacts; other site 1117943019102 MoFe protein dimer/ dimer interactions; other site 1117943019103 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 1117943019104 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 1117943019105 MoFe protein alpha/beta subunit interactions; other site 1117943019106 Alpha subunit P cluster binding residues; other site 1117943019107 FeMoco binding residues [chemical binding]; other site 1117943019108 MoFe protein alpha subunit/Fe protein contacts; other site 1117943019109 MoFe protein dimer/ dimer interactions; other site 1117943019110 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 1117943019111 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1117943019112 Nucleotide-binding sites [chemical binding]; other site 1117943019113 Walker A motif; other site 1117943019114 Switch I region of nucleotide binding site; other site 1117943019115 Fe4S4 binding sites [ion binding]; other site 1117943019116 Switch II region of nucleotide binding site; other site 1117943019117 Integrase core domain; Region: rve; cl01316 1117943019118 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1117943019119 Integrase core domain; Region: rve; pfam00665 1117943019120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943019121 sequence-specific DNA binding site [nucleotide binding]; other site 1117943019122 salt bridge; other site 1117943019123 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1117943019124 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1117943019125 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1117943019126 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1117943019127 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1117943019128 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1117943019129 Integrase core domain; Region: rve; cl01316 1117943019130 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1117943019131 Integrase core domain; Region: rve; pfam00665 1117943019132 hypothetical protein; Provisional; Region: PRK06215 1117943019133 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; pfam02902 1117943019134 Integrase core domain; Region: rve; pfam00665 1117943019135 transposase; Validated; Region: PRK08181 1117943019136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943019137 Walker A motif; other site 1117943019138 ATP binding site [chemical binding]; other site 1117943019139 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943019140 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943019141 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943019142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1117943019143 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1117943019144 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943019145 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943019146 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943019147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1117943019148 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1117943019149 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943019150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943019151 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943019152 Integrase core domain; Region: rve; cl01316 1117943019153 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1117943019154 Integrase core domain; Region: rve; pfam00665 1117943019155 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943019156 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943019157 Winged helix-turn helix; Region: HTH_33; pfam13592 1117943019158 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943019159 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1117943019160 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1117943019161 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1117943019162 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1117943019163 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1117943019164 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1117943019165 HTH-like domain; Region: HTH_21; pfam13276 1117943019166 Integrase core domain; Region: rve; pfam00665 1117943019167 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1117943019168 DNA-binding interface [nucleotide binding]; DNA binding site 1117943019169 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943019170 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943019171 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943019172 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943019173 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943019174 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943019175 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943019176 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943019177 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1117943019178 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1117943019179 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1117943019180 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943019181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943019182 homodimer interface [polypeptide binding]; other site 1117943019183 catalytic residue [active] 1117943019184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943019185 putative substrate translocation pore; other site 1117943019186 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943019187 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943019188 sequence-specific DNA binding site [nucleotide binding]; other site 1117943019189 salt bridge; other site 1117943019190 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1117943019191 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1117943019192 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1117943019193 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1117943019194 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1117943019195 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943019196 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943019197 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943019198 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1117943019199 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 1117943019200 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1117943019201 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1117943019202 Protein of unknown function, DUF269; Region: DUF269; cl03973 1117943019203 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1117943019204 probable nitrogen fixation protein; Region: TIGR02935 1117943019205 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 1117943019206 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1117943019207 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 1117943019208 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 1117943019209 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 1117943019210 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 1117943019211 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 1117943019212 MoFe protein beta/alpha subunit interactions; other site 1117943019213 Beta subunit P cluster binding residues; other site 1117943019214 MoFe protein beta subunit/Fe protein contacts; other site 1117943019215 MoFe protein dimer/ dimer interactions; other site 1117943019216 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 1117943019217 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 1117943019218 MoFe protein alpha/beta subunit interactions; other site 1117943019219 Alpha subunit P cluster binding residues; other site 1117943019220 FeMoco binding residues [chemical binding]; other site 1117943019221 MoFe protein alpha subunit/Fe protein contacts; other site 1117943019222 MoFe protein dimer/ dimer interactions; other site 1117943019223 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 1117943019224 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1117943019225 Nucleotide-binding sites [chemical binding]; other site 1117943019226 Walker A motif; other site 1117943019227 Switch I region of nucleotide binding site; other site 1117943019228 Fe4S4 binding sites [ion binding]; other site 1117943019229 Switch II region of nucleotide binding site; other site 1117943019230 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1117943019231 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1117943019232 short chain dehydrogenase; Validated; Region: PRK06484 1117943019233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943019234 NAD(P) binding site [chemical binding]; other site 1117943019235 active site 1117943019236 classical (c) SDRs; Region: SDR_c; cd05233 1117943019237 NAD(P) binding site [chemical binding]; other site 1117943019238 active site 1117943019239 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1117943019240 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1117943019241 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1117943019242 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1117943019243 NifQ; Region: NifQ; pfam04891 1117943019244 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1117943019245 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1117943019246 catalytic triad [active] 1117943019247 dimer interface [polypeptide binding]; other site 1117943019248 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1117943019249 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1117943019250 Ligand binding site [chemical binding]; other site 1117943019251 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1117943019252 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1117943019253 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1117943019254 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1117943019255 oxidoreductase; Provisional; Region: PRK10015 1117943019256 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1117943019257 Nif-specific regulatory protein; Region: nifA; TIGR01817 1117943019258 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1117943019259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943019260 Walker A motif; other site 1117943019261 ATP binding site [chemical binding]; other site 1117943019262 Walker B motif; other site 1117943019263 arginine finger; other site 1117943019264 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1117943019265 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 1117943019266 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1117943019267 FeS/SAM binding site; other site 1117943019268 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 1117943019269 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1117943019270 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1117943019271 NifZ domain; Region: NifZ; pfam04319 1117943019272 NifT/FixU protein; Region: NifT; pfam06988 1117943019273 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1117943019274 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1117943019275 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943019276 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943019277 DDE superfamily endonuclease; Region: DDE_4; cl15789 1117943019278 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1117943019279 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1117943019280 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1117943019281 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1117943019282 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1117943019283 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1117943019284 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1117943019285 catalytic residue [active] 1117943019286 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810 1117943019287 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1117943019288 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943019289 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943019290 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943019291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943019292 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943019293 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943019294 Integrase core domain; Region: rve; pfam00665 1117943019295 transposase; Validated; Region: PRK08181 1117943019296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943019297 Walker A motif; other site 1117943019298 ATP binding site [chemical binding]; other site 1117943019299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943019300 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943019301 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943019302 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1117943019303 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943019304 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943019305 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1117943019306 Helix-turn-helix domains; Region: HTH; cl00088 1117943019307 Putative transposase; Region: Y2_Tnp; pfam04986 1117943019308 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 1117943019309 Putative transposase; Region: Y2_Tnp; pfam04986 1117943019310 integron integrase; Region: integrase_gron; TIGR02249 1117943019311 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 1117943019312 Int/Topo IB signature motif; other site 1117943019313 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 1117943019314 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1117943019315 Transposase; Region: HTH_Tnp_1; pfam01527 1117943019316 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943019317 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1117943019318 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943019319 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943019320 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943019321 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1117943019322 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1117943019323 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943019324 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943019325 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943019326 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1117943019327 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1117943019328 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1117943019329 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943019330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943019331 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943019332 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1117943019333 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943019334 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943019335 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943019336 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943019337 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943019338 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1117943019339 active site 1117943019340 catalytic residues [active] 1117943019341 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1117943019342 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943019343 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943019344 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943019345 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943019346 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943019347 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943019348 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943019349 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943019350 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943019351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943019352 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943019353 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1117943019354 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 1117943019355 Int/Topo IB signature motif; other site 1117943019356 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943019357 active site 1117943019358 DNA binding site [nucleotide binding] 1117943019359 Int/Topo IB signature motif; other site 1117943019360 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943019361 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1117943019362 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1117943019363 homotetramer interface [polypeptide binding]; other site 1117943019364 FMN binding site [chemical binding]; other site 1117943019365 homodimer contacts [polypeptide binding]; other site 1117943019366 putative active site [active] 1117943019367 putative substrate binding site [chemical binding]; other site 1117943019368 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1117943019369 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1117943019370 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1117943019371 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1117943019372 substrate binding pocket [chemical binding]; other site 1117943019373 chain length determination region; other site 1117943019374 substrate-Mg2+ binding site; other site 1117943019375 catalytic residues [active] 1117943019376 aspartate-rich region 1; other site 1117943019377 active site lid residues [active] 1117943019378 aspartate-rich region 2; other site 1117943019379 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1117943019380 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943019381 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943019382 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943019383 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943019384 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943019385 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943019386 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943019387 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943019388 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1117943019389 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1117943019390 Integrase core domain; Region: rve; pfam00665 1117943019391 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1117943019392 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1117943019393 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1117943019394 putative active site [active] 1117943019395 putative NTP binding site [chemical binding]; other site 1117943019396 putative nucleic acid binding site [nucleotide binding]; other site 1117943019397 Putative transposase; Region: Y2_Tnp; pfam04986 1117943019398 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1117943019399 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1117943019400 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1117943019401 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1117943019402 nodulation factor exporter subunit NodI; Provisional; Region: PRK13536 1117943019403 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1117943019404 Walker A/P-loop; other site 1117943019405 ATP binding site [chemical binding]; other site 1117943019406 Q-loop/lid; other site 1117943019407 ABC transporter signature motif; other site 1117943019408 Walker B; other site 1117943019409 D-loop; other site 1117943019410 H-loop/switch region; other site 1117943019411 chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242 1117943019412 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1117943019413 DXD motif; other site 1117943019414 chitooligosaccharide deacetylase NodB; Region: nodulat_NodB; TIGR04243 1117943019415 Nodulation protein A (NodA); Region: NodA; pfam02474 1117943019416 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 1117943019417 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943019418 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943019419 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943019420 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943019421 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943019422 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943019423 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943019424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943019425 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1117943019426 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943019427 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943019428 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1117943019429 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943019430 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943019431 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1117943019432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1117943019433 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1117943019434 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1117943019435 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943019436 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943019437 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943019438 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1117943019439 Transposase; Region: HTH_Tnp_1; pfam01527 1117943019440 Integrase core domain; Region: rve; cl01316 1117943019441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1117943019442 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943019443 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943019444 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1117943019445 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943019446 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943019447 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1117943019448 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1117943019449 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1117943019450 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943019451 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943019452 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943019453 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943019454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1117943019455 Transposase; Region: HTH_Tnp_1; pfam01527 1117943019456 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1117943019457 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943019458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943019459 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943019460 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1117943019461 Transposase domain (DUF772); Region: DUF772; pfam05598 1117943019462 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943019463 DDE superfamily endonuclease; Region: DDE_4; cl15789 1117943019464 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1117943019465 MULE transposase domain; Region: MULE; pfam10551 1117943019466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1117943019467 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1117943019468 active site 1117943019469 Transposase domain (DUF772); Region: DUF772; pfam05598 1117943019470 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943019471 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1117943019472 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1117943019473 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1117943019474 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1117943019475 DNA binding residues [nucleotide binding] 1117943019476 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1117943019477 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1117943019478 HSP70 interaction site [polypeptide binding]; other site 1117943019479 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1117943019480 substrate binding site [polypeptide binding]; other site 1117943019481 dimer interface [polypeptide binding]; other site 1117943019482 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1117943019483 acetyl-CoA synthetase; Provisional; Region: PRK04319 1117943019484 AMP-binding enzyme; Region: AMP-binding; pfam00501 1117943019485 Domain of unknown function (DUF4009); Region: DUF4009; pfam13193 1117943019486 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1117943019487 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1117943019488 tetramer interface [polypeptide binding]; other site 1117943019489 TPP-binding site [chemical binding]; other site 1117943019490 heterodimer interface [polypeptide binding]; other site 1117943019491 phosphorylation loop region [posttranslational modification] 1117943019492 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1117943019493 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1117943019494 alpha subunit interface [polypeptide binding]; other site 1117943019495 TPP binding site [chemical binding]; other site 1117943019496 heterodimer interface [polypeptide binding]; other site 1117943019497 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1117943019498 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1117943019499 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1117943019500 E3 interaction surface; other site 1117943019501 lipoyl attachment site [posttranslational modification]; other site 1117943019502 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1117943019503 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 1117943019504 FtsH Extracellular; Region: FtsH_ext; pfam06480 1117943019505 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1117943019506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943019507 Walker A motif; other site 1117943019508 ATP binding site [chemical binding]; other site 1117943019509 Walker B motif; other site 1117943019510 arginine finger; other site 1117943019511 Peptidase family M41; Region: Peptidase_M41; pfam01434 1117943019512 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1117943019513 Ligand Binding Site [chemical binding]; other site 1117943019514 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1117943019515 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1117943019516 active site 1117943019517 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1117943019518 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1117943019519 putative dimer interface [polypeptide binding]; other site 1117943019520 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1117943019521 AMP-binding enzyme; Region: AMP-binding; pfam00501 1117943019522 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1117943019523 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1117943019524 putative acyl-acceptor binding pocket; other site 1117943019525 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1117943019526 hypothetical protein; Provisional; Region: PRK08609 1117943019527 active site 1117943019528 primer binding site [nucleotide binding]; other site 1117943019529 NTP binding site [chemical binding]; other site 1117943019530 metal binding triad [ion binding]; metal-binding site 1117943019531 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 1117943019532 active site 1117943019533 Protein required for attachment to host cells; Region: Host_attach; pfam10116 1117943019534 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1117943019535 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1117943019536 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1117943019537 Walker A/P-loop; other site 1117943019538 ATP binding site [chemical binding]; other site 1117943019539 Q-loop/lid; other site 1117943019540 ABC transporter signature motif; other site 1117943019541 Walker B; other site 1117943019542 D-loop; other site 1117943019543 H-loop/switch region; other site 1117943019544 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1117943019545 BON domain; Region: BON; pfam04972 1117943019546 BON domain; Region: BON; pfam04972 1117943019547 BON domain; Region: BON; pfam04972 1117943019548 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1117943019549 BON domain; Region: BON; pfam04972 1117943019550 BON domain; Region: BON; pfam04972 1117943019551 Phosphotransferase enzyme family; Region: APH; pfam01636 1117943019552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1117943019553 Predicted kinase [General function prediction only]; Region: COG0645 1117943019554 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1117943019555 active site 1117943019556 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1117943019557 glucokinase, proteobacterial type; Region: glk; TIGR00749 1117943019558 Protein required for attachment to host cells; Region: Host_attach; pfam10116 1117943019559 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1117943019560 active site 1117943019561 putative substrate binding region [chemical binding]; other site 1117943019562 FOG: CBS domain [General function prediction only]; Region: COG0517 1117943019563 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639 1117943019564 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1117943019565 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1117943019566 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943019567 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1117943019568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943019569 intermolecular recognition site; other site 1117943019570 active site 1117943019571 dimerization interface [polypeptide binding]; other site 1117943019572 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943019573 DNA binding site [nucleotide binding] 1117943019574 BON domain; Region: BON; pfam04972 1117943019575 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1117943019576 BON domain; Region: BON; pfam04972 1117943019577 BON domain; Region: BON; pfam04972 1117943019578 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 1117943019579 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 1117943019580 30S subunit binding site; other site 1117943019581 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1117943019582 DNA-binding site [nucleotide binding]; DNA binding site 1117943019583 RNA-binding motif; other site 1117943019584 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1117943019585 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1117943019586 ligand binding site [chemical binding]; other site 1117943019587 flexible hinge region; other site 1117943019588 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1117943019589 putative switch regulator; other site 1117943019590 non-specific DNA interactions [nucleotide binding]; other site 1117943019591 DNA binding site [nucleotide binding] 1117943019592 sequence specific DNA binding site [nucleotide binding]; other site 1117943019593 putative cAMP binding site [chemical binding]; other site 1117943019594 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1117943019595 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1117943019596 ligand binding site [chemical binding]; other site 1117943019597 flexible hinge region; other site 1117943019598 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1117943019599 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943019600 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1117943019601 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943019602 motif II; other site 1117943019603 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1117943019604 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1117943019605 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1117943019606 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943019607 Glycerate kinase family; Region: Gly_kinase; cl00841 1117943019608 ChaB; Region: ChaB; pfam06150 1117943019609 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1117943019610 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1117943019611 active site 1117943019612 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1117943019613 Putative glucoamylase; Region: Glycoamylase; pfam10091 1117943019614 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 1117943019615 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1117943019616 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 1117943019617 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1117943019618 Ligand Binding Site [chemical binding]; other site 1117943019619 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1117943019620 Ligand Binding Site [chemical binding]; other site 1117943019621 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1117943019622 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1117943019623 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1117943019624 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1117943019625 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1117943019626 catalytic residue [active] 1117943019627 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1117943019628 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943019629 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943019630 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1117943019631 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943019632 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943019633 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1117943019634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943019635 dimer interface [polypeptide binding]; other site 1117943019636 conserved gate region; other site 1117943019637 putative PBP binding loops; other site 1117943019638 ABC-ATPase subunit interface; other site 1117943019639 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1117943019640 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 1117943019641 Walker A/P-loop; other site 1117943019642 ATP binding site [chemical binding]; other site 1117943019643 Q-loop/lid; other site 1117943019644 ABC transporter signature motif; other site 1117943019645 Walker B; other site 1117943019646 D-loop; other site 1117943019647 H-loop/switch region; other site 1117943019648 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1117943019649 NMT1-like family; Region: NMT1_2; pfam13379 1117943019650 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1117943019651 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1117943019652 putative substrate binding site [chemical binding]; other site 1117943019653 putative ATP binding site [chemical binding]; other site 1117943019654 FOG: CBS domain [General function prediction only]; Region: COG0517 1117943019655 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 1117943019656 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 1117943019657 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1117943019658 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1117943019659 active site 1117943019660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1117943019661 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1117943019662 Ligand Binding Site [chemical binding]; other site 1117943019663 chaperonin GroEL; Reviewed; Region: groEL; PRK12851 1117943019664 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1117943019665 ring oligomerisation interface [polypeptide binding]; other site 1117943019666 ATP/Mg binding site [chemical binding]; other site 1117943019667 stacking interactions; other site 1117943019668 hinge regions; other site 1117943019669 Domain of unknown function (DUF1476); Region: DUF1476; cl11571 1117943019670 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1117943019671 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1117943019672 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1117943019673 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1117943019674 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1117943019675 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1117943019676 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1117943019677 putative dimer interface [polypeptide binding]; other site 1117943019678 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1117943019679 Ligand Binding Site [chemical binding]; other site 1117943019680 Protein required for attachment to host cells; Region: Host_attach; pfam10116 1117943019681 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1117943019682 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1117943019683 Walker A/P-loop; other site 1117943019684 ATP binding site [chemical binding]; other site 1117943019685 Q-loop/lid; other site 1117943019686 ABC transporter signature motif; other site 1117943019687 Walker B; other site 1117943019688 D-loop; other site 1117943019689 H-loop/switch region; other site 1117943019690 FtsX-like permease family; Region: FtsX; pfam02687 1117943019691 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1117943019692 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1117943019693 FtsX-like permease family; Region: FtsX; pfam02687 1117943019694 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1117943019695 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943019696 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1117943019697 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1117943019698 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943019699 protein binding site [polypeptide binding]; other site 1117943019700 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943019701 protein binding site [polypeptide binding]; other site 1117943019702 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1117943019703 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1117943019704 Beta-Casp domain; Region: Beta-Casp; smart01027 1117943019705 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1117943019706 ornithine carbamoyltransferase; Validated; Region: PRK02102 1117943019707 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1117943019708 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1117943019709 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1117943019710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943019711 active site 1117943019712 phosphorylation site [posttranslational modification] 1117943019713 intermolecular recognition site; other site 1117943019714 dimerization interface [polypeptide binding]; other site 1117943019715 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943019716 DNA binding site [nucleotide binding] 1117943019717 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 1117943019718 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1117943019719 ligand binding site [chemical binding]; other site 1117943019720 flexible hinge region; other site 1117943019721 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1117943019722 putative switch regulator; other site 1117943019723 non-specific DNA interactions [nucleotide binding]; other site 1117943019724 DNA binding site [nucleotide binding] 1117943019725 sequence specific DNA binding site [nucleotide binding]; other site 1117943019726 putative cAMP binding site [chemical binding]; other site 1117943019727 PAS domain S-box; Region: sensory_box; TIGR00229 1117943019728 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943019729 putative active site [active] 1117943019730 heme pocket [chemical binding]; other site 1117943019731 PAS domain S-box; Region: sensory_box; TIGR00229 1117943019732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943019733 putative active site [active] 1117943019734 heme pocket [chemical binding]; other site 1117943019735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943019736 dimer interface [polypeptide binding]; other site 1117943019737 phosphorylation site [posttranslational modification] 1117943019738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943019739 ATP binding site [chemical binding]; other site 1117943019740 G-X-G motif; other site 1117943019741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943019742 phosphorylation site [posttranslational modification] 1117943019743 intermolecular recognition site; other site 1117943019744 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1117943019745 magnesium-transporting ATPase; Provisional; Region: PRK15122 1117943019746 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943019747 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1117943019748 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1117943019749 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1117943019750 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1117943019751 CoA binding domain; Region: CoA_binding_2; pfam13380 1117943019752 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1117943019753 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1117943019754 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1117943019755 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1117943019756 Ligand Binding Site [chemical binding]; other site 1117943019757 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1117943019758 Ligand Binding Site [chemical binding]; other site 1117943019759 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 1117943019760 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1117943019761 BON domain; Region: BON; pfam04972 1117943019762 BON domain; Region: BON; pfam04972 1117943019763 BON domain; Region: BON; pfam04972 1117943019764 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1117943019765 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1117943019766 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943019767 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1117943019768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943019769 motif II; other site 1117943019770 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1117943019771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1117943019772 Phosphotransferase enzyme family; Region: APH; pfam01636 1117943019773 Predicted kinase [General function prediction only]; Region: COG0645 1117943019774 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1117943019775 active site 1117943019776 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 1117943019777 active site 1117943019778 Predicted membrane protein [Function unknown]; Region: COG3174 1117943019779 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 1117943019780 Predicted membrane protein [Function unknown]; Region: COG3619 1117943019781 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1117943019782 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943019783 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1117943019784 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1117943019785 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1117943019786 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1117943019787 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1117943019788 Cytochrome c; Region: Cytochrom_C; pfam00034 1117943019789 Predicted transporter component [General function prediction only]; Region: COG2391 1117943019790 Sulphur transport; Region: Sulf_transp; pfam04143 1117943019791 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1117943019792 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943019793 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1117943019794 FtsX-like permease family; Region: FtsX; pfam02687 1117943019795 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1117943019796 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1117943019797 FtsX-like permease family; Region: FtsX; pfam02687 1117943019798 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1117943019799 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1117943019800 ABC transporter signature motif; other site 1117943019801 Walker B; other site 1117943019802 D-loop; other site 1117943019803 H-loop/switch region; other site 1117943019804 LTXXQ motif family protein; Region: LTXXQ; pfam07813 1117943019805 putative phosphoketolase; Provisional; Region: PRK05261 1117943019806 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1117943019807 TPP-binding site; other site 1117943019808 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 1117943019809 XFP C-terminal domain; Region: XFP_C; pfam09363 1117943019810 FOG: CBS domain [General function prediction only]; Region: COG0517 1117943019811 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 1117943019812 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1117943019813 BON domain; Region: BON; pfam04972 1117943019814 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1117943019815 ABC1 family; Region: ABC1; pfam03109 1117943019816 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1117943019817 active site 1117943019818 ATP binding site [chemical binding]; other site 1117943019819 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 1117943019820 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1117943019821 Walker A motif; other site 1117943019822 hexamer interface [polypeptide binding]; other site 1117943019823 ATP binding site [chemical binding]; other site 1117943019824 Walker B motif; other site 1117943019825 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 1117943019826 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1117943019827 VirB7 interaction site; other site 1117943019828 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 1117943019829 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 1117943019830 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 1117943019831 Type IV secretion system proteins; Region: T4SS; pfam07996 1117943019832 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 1117943019833 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1117943019834 Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702 1117943019835 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 1117943019836 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1117943019837 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1117943019838 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 1117943019839 MerR family regulatory protein; Region: MerR; pfam00376 1117943019840 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1117943019841 P-loop; other site 1117943019842 Magnesium ion binding site [ion binding]; other site 1117943019843 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 1117943019844 ParB-like nuclease domain; Region: ParB; smart00470 1117943019845 replication initiation protein RepC; Provisional; Region: PRK13824 1117943019846 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1117943019847 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 1117943019848 LabA_like proteins; Region: LabA_like/DUF88; cl10034 1117943019849 putative metal binding site [ion binding]; other site 1117943019850 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 1117943019851 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1117943019852 DNA-binding site [nucleotide binding]; DNA binding site 1117943019853 RNA-binding motif; other site 1117943019854 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943019855 Int/Topo IB signature motif; other site 1117943019856 DNA binding site [nucleotide binding] 1117943019857 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 1117943019858 HTH DNA binding domain; Region: HTH_13; pfam11972 1117943019859 Competence protein CoiA-like family; Region: CoiA; cl11541 1117943019860 Superfamily II helicase [General function prediction only]; Region: COG1204 1117943019861 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1117943019862 ATP binding site [chemical binding]; other site 1117943019863 putative Mg++ binding site [ion binding]; other site 1117943019864 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 1117943019865 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1117943019866 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1117943019867 AAA domain; Region: AAA_11; pfam13086 1117943019868 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1117943019869 G1 box; other site 1117943019870 GTP/Mg2+ binding site [chemical binding]; other site 1117943019871 G2 box; other site 1117943019872 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1117943019873 AAA domain; Region: AAA_12; pfam13087 1117943019874 MarR family; Region: MarR_2; pfam12802 1117943019875 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1117943019876 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 1117943019877 putative active site [active] 1117943019878 putative catalytic site [active] 1117943019879 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 1117943019880 putative active site [active] 1117943019881 putative catalytic site [active] 1117943019882 Part of AAA domain; Region: AAA_19; pfam13245 1117943019883 Family description; Region: UvrD_C_2; pfam13538 1117943019884 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1117943019885 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 1117943019886 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1117943019887 active site 1117943019888 substrate binding site [chemical binding]; other site 1117943019889 catalytic site [active] 1117943019890 Protein of unknown function (DUF429); Region: DUF429; cl12046 1117943019891 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1117943019892 ATP binding site [chemical binding]; other site 1117943019893 putative Mg++ binding site [ion binding]; other site 1117943019894 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1117943019895 nucleotide binding region [chemical binding]; other site 1117943019896 ATP-binding site [chemical binding]; other site 1117943019897 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1117943019898 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1117943019899 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1117943019900 active site 1117943019901 DNA polymerase IV; Validated; Region: PRK02406 1117943019902 DNA binding site [nucleotide binding] 1117943019903 Uncharacterized conserved protein [Function unknown]; Region: COG4544 1117943019904 DNA Polymerase Y-family; Region: PolY_like; cd03468 1117943019905 active site 1117943019906 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1117943019907 DNA binding site [nucleotide binding] 1117943019908 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1117943019909 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1117943019910 generic binding surface I; other site 1117943019911 generic binding surface II; other site 1117943019912 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1117943019913 ParB-like nuclease domain; Region: ParBc; pfam02195 1117943019914 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1117943019915 Antirestriction protein; Region: Antirestrict; pfam03230 1117943019916 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 1117943019917 YodA lipocalin-like domain; Region: YodA; pfam09223 1117943019918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943019919 S-adenosylmethionine binding site [chemical binding]; other site 1117943019920 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1117943019921 ATP binding site [chemical binding]; other site 1117943019922 putative Mg++ binding site [ion binding]; other site 1117943019923 Helicase_C-like; Region: Helicase_C_4; pfam13871 1117943019924 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1117943019925 active site 1117943019926 metal binding site [ion binding]; metal-binding site 1117943019927 interdomain interaction site; other site 1117943019928 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 1117943019929 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1117943019930 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1117943019931 putative active site [active] 1117943019932 Uncharacterized conserved protein [Function unknown]; Region: COG5489 1117943019933 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1117943019934 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 1117943019935 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 1117943019936 Walker A motif; other site 1117943019937 ATP binding site [chemical binding]; other site 1117943019938 Walker B motif; other site 1117943019939 Conjugal transfer protein TraD; Region: TraD; pfam06412 1117943019940 TraC-like protein; Region: TraC; pfam07820 1117943019941 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 1117943019942 MobA/MobL family; Region: MobA_MobL; pfam03389 1117943019943 AAA domain; Region: AAA_30; pfam13604 1117943019944 Family description; Region: UvrD_C_2; pfam13538 1117943019945 Zeta toxin; Region: Zeta_toxin; pfam06414 1117943019946 XK-related protein; Region: XK-related; pfam09815 1117943019947 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1117943019948 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1117943019949 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1117943019950 HWE histidine kinase; Region: HWE_HK; smart00911 1117943019951 Domain of unknown function DUF302; Region: DUF302; pfam03625 1117943019952 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1117943019953 Integrase core domain; Region: rve; cl01316 1117943019954 Protein of unknown function (DUF1515); Region: DUF1515; pfam07439 1117943019955 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943019956 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943019957 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1117943019958 Transposase domain (DUF772); Region: DUF772; pfam05598 1117943019959 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943019960 DDE superfamily endonuclease; Region: DDE_4; cl15789 1117943019961 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1117943019962 MULE transposase domain; Region: MULE; pfam10551 1117943019963 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1117943019964 Integrase core domain; Region: rve; pfam00665 1117943019965 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1117943019966 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1117943019967 AAA domain; Region: AAA_22; pfam13401 1117943019968 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1117943019969 Restriction endonuclease; Region: Mrr_cat; pfam04471 1117943019970 Integrase core domain; Region: rve; cl01316 1117943019971 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1117943019972 Leucine rich repeat; Region: LRR_8; pfam13855 1117943019973 Leucine-rich repeats, bacterial type; Region: LRR_BAC; smart00364 1117943019974 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1117943019975 Leucine rich repeat; Region: LRR_8; pfam13855 1117943019976 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1117943019977 Integrase core domain; Region: rve; pfam00665 1117943019978 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1117943019981 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1117943019982 Walker A/P-loop; other site 1117943019983 ATP binding site [chemical binding]; other site 1117943019984 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 1117943019985 Integrase core domain; Region: rve; cl01316 1117943019986 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1117943019987 Integrase core domain; Region: rve; pfam00665 1117943019988 Phasin protein; Region: Phasin_2; cl11491 1117943019989 Helix-turn-helix domains; Region: HTH; cl00088 1117943019990 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1117943019991 HTH-like domain; Region: HTH_21; pfam13276 1117943019992 Integrase core domain; Region: rve; pfam00665 1117943019993 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943019994 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943019995 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943019996 Winged helix-turn helix; Region: HTH_33; pfam13592 1117943019997 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1117943019998 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1117943019999 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1117943020000 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1117943020001 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1117943020002 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1117943020003 MULE transposase domain; Region: MULE; pfam10551 1117943020004 Transposase domain (DUF772); Region: DUF772; pfam05598 1117943020005 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943020006 DDE superfamily endonuclease; Region: DDE_4; cl15789 1117943020007 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1117943020008 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1117943020009 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1117943020010 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1117943020011 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1117943020012 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1117943020013 Integrase core domain; Region: rve; cl01316 1117943020014 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1117943020015 Integrase core domain; Region: rve; pfam00665 1117943020016 Helix-turn-helix domains; Region: HTH; cl00088 1117943020017 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943020018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943020019 non-specific DNA binding site [nucleotide binding]; other site 1117943020020 salt bridge; other site 1117943020021 sequence-specific DNA binding site [nucleotide binding]; other site 1117943020022 Prokaryotic Transcriptional repressor TraM; Region: Prok-TraM; pfam09228 1117943020023 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943020024 DNA binding residues [nucleotide binding] 1117943020025 dimerization interface [polypeptide binding]; other site 1117943020026 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1117943020027 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 1117943020028 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 1117943020029 conjugal transfer protein TrbH; Provisional; Region: PRK13835 1117943020030 Conjugal transfer protein TrbH; Region: TrbH; pfam07283 1117943020031 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1117943020032 VirB7 interaction site; other site 1117943020033 conjugal transfer protein TrbF; Provisional; Region: PRK13836 1117943020034 conjugal transfer protein TrbL; Provisional; Region: PRK13841 1117943020035 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 1117943020036 Protein of unknown function (DUF2749); Region: DUF2749; pfam10907 1117943020037 conjugal transfer protein TrbJ; Provisional; Region: PRK13842 1117943020038 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1117943020039 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1117943020040 AAA-like domain; Region: AAA_10; pfam12846 1117943020041 Walker A/P-loop; other site 1117943020042 ATP binding site [chemical binding]; other site 1117943020043 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943020044 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943020045 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943020046 conjugal transfer protein TrbE; Provisional; Region: PRK13830 1117943020047 conjugal transfer protein TrbD; Provisional; Region: PRK13823 1117943020048 TrbC/VIRB2 family; Region: TrbC; cl01583 1117943020049 conjugal transfer protein TrbB; Provisional; Region: PRK13833 1117943020050 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1117943020051 ATP binding site [chemical binding]; other site 1117943020052 Walker A motif; other site 1117943020053 hexamer interface [polypeptide binding]; other site 1117943020054 Walker B motif; other site 1117943020055 putative autoinducer synthesis protein; Provisional; Region: PRK13834 1117943020056 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 1117943020057 MerR family regulatory protein; Region: MerR; pfam00376 1117943020058 DNA binding residues [nucleotide binding] 1117943020059 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1117943020060 P-loop; other site 1117943020061 Magnesium ion binding site [ion binding]; other site 1117943020062 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1117943020063 Magnesium ion binding site [ion binding]; other site 1117943020064 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 1117943020065 ParB-like nuclease domain; Region: ParBc; pfam02195 1117943020066 replication initiation protein RepC; Provisional; Region: PRK13824 1117943020067 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1117943020068 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 1117943020069 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1117943020070 DNA-binding site [nucleotide binding]; DNA binding site 1117943020071 RNA-binding motif; other site 1117943020072 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1117943020073 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1117943020074 catalytic residues [active] 1117943020075 catalytic nucleophile [active] 1117943020076 Presynaptic Site I dimer interface [polypeptide binding]; other site 1117943020077 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1117943020078 Synaptic Flat tetramer interface [polypeptide binding]; other site 1117943020079 Synaptic Site I dimer interface [polypeptide binding]; other site 1117943020080 DNA binding site [nucleotide binding] 1117943020081 Permease; Region: Permease; cl00510 1117943020082 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1117943020083 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1117943020084 FeS/SAM binding site; other site 1117943020085 Agmatinase-like family; Region: Agmatinase-like; cd09990 1117943020086 active site 1117943020087 oligomer interface [polypeptide binding]; other site 1117943020088 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1117943020089 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1117943020090 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 1117943020091 AAA domain; Region: AAA_23; pfam13476 1117943020092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943020093 Walker A/P-loop; other site 1117943020094 ATP binding site [chemical binding]; other site 1117943020096 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943020097 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943020098 Winged helix-turn helix; Region: HTH_33; pfam13592 1117943020099 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943020100 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943020101 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943020102 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943020103 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1117943020104 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1117943020105 Sulfatase; Region: Sulfatase; pfam00884 1117943020106 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 1117943020107 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1117943020108 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1117943020109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943020110 active site 1117943020111 phosphorylation site [posttranslational modification] 1117943020112 intermolecular recognition site; other site 1117943020113 dimerization interface [polypeptide binding]; other site 1117943020114 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943020115 DNA binding site [nucleotide binding] 1117943020116 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1117943020117 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943020118 non-specific DNA binding site [nucleotide binding]; other site 1117943020119 salt bridge; other site 1117943020120 sequence-specific DNA binding site [nucleotide binding]; other site 1117943020121 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1117943020122 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1117943020123 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943020124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1117943020125 Integrase core domain; Region: rve; pfam00665 1117943020126 Restriction endonuclease; Region: Mrr_cat; pfam04471 1117943020127 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1117943020128 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943020129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943020130 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943020131 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943020132 Winged helix-turn helix; Region: HTH_33; pfam13592 1117943020133 Integrase core domain; Region: rve; pfam00665 1117943020134 Alpha-helical domain of GINS complex proteins; Sld5, Psf1, Psf2 and Psf3; Region: GINS_A; cl17012 1117943020135 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943020136 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943020137 Winged helix-turn helix; Region: HTH_33; pfam13592 1117943020138 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943020139 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943020140 Homeodomain-like domain; Region: HTH_23; cl17451 1117943020141 putative transposase OrfB; Reviewed; Region: PHA02517 1117943020142 HTH-like domain; Region: HTH_21; pfam13276 1117943020143 Integrase core domain; Region: rve; pfam00665 1117943020144 Integrase core domain; Region: rve_3; pfam13683 1117943020145 Helix-turn-helix domain; Region: HTH_28; pfam13518 1117943020146 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943020147 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943020148 Helix-turn-helix domain; Region: HTH_28; pfam13518 1117943020149 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943020150 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943020151 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1117943020152 Helix-turn-helix domain; Region: HTH_38; pfam13936 1117943020153 Integrase core domain; Region: rve; pfam00665 1117943020154 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 1117943020155 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1117943020156 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943020157 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943020158 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943020159 Predicted transcriptional regulator [Transcription]; Region: COG4957 1117943020160 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943020161 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943020162 sequence-specific DNA binding site [nucleotide binding]; other site 1117943020163 salt bridge; other site 1117943020164 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943020165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943020166 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943020167 dimerization interface [polypeptide binding]; other site 1117943020168 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1117943020169 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1117943020170 Substrate binding site; other site 1117943020171 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1117943020172 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 1117943020173 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 1117943020174 active site 1117943020175 substrate binding site [chemical binding]; other site 1117943020176 metal binding site [ion binding]; metal-binding site 1117943020177 Nodulation protein Z (NodZ); Region: NodZ; pfam05830 1117943020178 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 1117943020179 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1117943020180 NADP-binding site; other site 1117943020181 homotetramer interface [polypeptide binding]; other site 1117943020182 substrate binding site [chemical binding]; other site 1117943020183 homodimer interface [polypeptide binding]; other site 1117943020184 active site 1117943020185 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1117943020186 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1117943020187 NADP binding site [chemical binding]; other site 1117943020188 active site 1117943020189 putative substrate binding site [chemical binding]; other site 1117943020190 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943020191 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943020192 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943020193 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943020194 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943020195 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943020196 SnoaL-like domain; Region: SnoaL_2; pfam12680 1117943020197 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1117943020198 active site lid residues [active] 1117943020199 substrate binding pocket [chemical binding]; other site 1117943020200 catalytic residues [active] 1117943020201 substrate-Mg2+ binding site; other site 1117943020202 aspartate-rich region 1; other site 1117943020203 aspartate-rich region 2; other site 1117943020204 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1117943020205 active site lid residues [active] 1117943020206 substrate binding pocket [chemical binding]; other site 1117943020207 catalytic residues [active] 1117943020208 substrate-Mg2+ binding site; other site 1117943020209 aspartate-rich region 1; other site 1117943020210 aspartate-rich region 2; other site 1117943020211 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 1117943020212 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1117943020213 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1117943020214 Active site cavity [active] 1117943020215 catalytic acid [active] 1117943020216 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943020217 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943020218 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1117943020219 dimerization interface [polypeptide binding]; other site 1117943020220 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; pfam03543 1117943020221 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1117943020222 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943020223 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943020224 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943020225 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943020226 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943020227 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943020228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943020229 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943020230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1117943020231 binding surface 1117943020232 TPR motif; other site 1117943020233 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1117943020234 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1117943020235 FHIPEP family; Region: FHIPEP; pfam00771 1117943020236 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1117943020237 Type III secretory pathway, component EscU [Intracellular trafficking and secretion]; Region: EscU; COG4792 1117943020238 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1117943020239 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 1117943020240 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 1117943020241 type III secretion system protein YscR; Provisional; Region: PRK12797 1117943020242 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 1117943020243 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1117943020244 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 1117943020245 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1117943020246 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1117943020247 Walker A motif; other site 1117943020248 ATP binding site [chemical binding]; other site 1117943020249 Walker B motif; other site 1117943020250 Nodulation protein NolV; Region: NolV; pfam06635 1117943020251 Flagellar assembly protein FliH; Region: FliH; pfam02108 1117943020252 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 1117943020253 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1117943020254 NolX protein; Region: NolX; pfam05819 1117943020255 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1117943020256 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1117943020257 catalytic residue [active] 1117943020258 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1117943020259 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1117943020260 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1117943020261 dimer interface [polypeptide binding]; other site 1117943020262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943020263 catalytic residue [active] 1117943020264 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1117943020265 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1117943020266 IucA / IucC family; Region: IucA_IucC; pfam04183 1117943020267 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1117943020268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943020269 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1117943020270 putative substrate translocation pore; other site 1117943020271 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943020272 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943020273 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943020274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943020275 Type IV pili component [Cell motility and secretion]; Region: COG5461 1117943020276 pilus (Caulobacter type) biogenesis lipoprotein CpaD; Region: pilus_cpaD; TIGR02522 1117943020277 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1117943020278 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1117943020279 BON domain; Region: BON; pfam04972 1117943020280 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1117943020281 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1117943020282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943020283 active site 1117943020284 phosphorylation site [posttranslational modification] 1117943020285 intermolecular recognition site; other site 1117943020286 dimerization interface [polypeptide binding]; other site 1117943020287 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943020288 DNA binding site [nucleotide binding] 1117943020289 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1117943020290 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1117943020291 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 1117943020292 putative substrate binding pocket [chemical binding]; other site 1117943020293 putative dimerization interface [polypeptide binding]; other site 1117943020294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943020295 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1117943020296 HTH-like domain; Region: HTH_21; pfam13276 1117943020297 Integrase core domain; Region: rve; pfam00665 1117943020298 Integrase core domain; Region: rve_3; pfam13683 1117943020299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943020300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943020301 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1117943020302 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1117943020303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943020304 Walker A motif; other site 1117943020305 ATP binding site [chemical binding]; other site 1117943020306 Walker B motif; other site 1117943020307 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1117943020308 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1117943020309 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1117943020310 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943020311 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943020312 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1117943020313 probable nitrogen fixation protein; Region: TIGR02935 1117943020314 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 1117943020315 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 1117943020316 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 1117943020317 MoFe protein beta/alpha subunit interactions; other site 1117943020318 Beta subunit P cluster binding residues; other site 1117943020319 MoFe protein beta subunit/Fe protein contacts; other site 1117943020320 MoFe protein dimer/ dimer interactions; other site 1117943020321 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 1117943020322 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 1117943020323 MoFe protein alpha/beta subunit interactions; other site 1117943020324 Alpha subunit P cluster binding residues; other site 1117943020325 FeMoco binding residues [chemical binding]; other site 1117943020326 MoFe protein alpha subunit/Fe protein contacts; other site 1117943020327 MoFe protein dimer/ dimer interactions; other site 1117943020328 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 1117943020329 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1117943020330 Nucleotide-binding sites [chemical binding]; other site 1117943020331 Walker A motif; other site 1117943020332 Switch I region of nucleotide binding site; other site 1117943020333 Fe4S4 binding sites [ion binding]; other site 1117943020334 Switch II region of nucleotide binding site; other site 1117943020335 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943020336 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1117943020337 Integrase core domain; Region: rve; pfam00665 1117943020338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943020339 sequence-specific DNA binding site [nucleotide binding]; other site 1117943020340 salt bridge; other site 1117943020341 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1117943020342 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1117943020343 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1117943020344 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1117943020345 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1117943020346 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1117943020347 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943020348 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1117943020349 Integrase core domain; Region: rve; pfam00665 1117943020350 hypothetical protein; Provisional; Region: PRK06215 1117943020351 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 1117943020352 Integrase core domain; Region: rve; pfam00665 1117943020353 transposase; Validated; Region: PRK08181 1117943020354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943020355 Walker A motif; other site 1117943020356 ATP binding site [chemical binding]; other site 1117943020357 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943020358 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943020359 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943020360 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1117943020361 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1117943020362 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943020363 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943020364 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943020365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1117943020366 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1117943020367 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943020368 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943020369 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943020370 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943020371 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1117943020372 Integrase core domain; Region: rve; pfam00665 1117943020373 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943020374 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943020375 Winged helix-turn helix; Region: HTH_33; pfam13592 1117943020376 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943020377 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943020378 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1117943020379 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1117943020380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1117943020381 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1117943020382 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1117943020383 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1117943020384 HTH-like domain; Region: HTH_21; pfam13276 1117943020385 Integrase core domain; Region: rve; pfam00665 1117943020386 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1117943020387 DNA-binding interface [nucleotide binding]; DNA binding site 1117943020388 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943020389 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943020390 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943020391 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943020392 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943020393 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943020394 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943020395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943020396 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1117943020397 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1117943020398 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1117943020399 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1117943020400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1117943020401 homodimer interface [polypeptide binding]; other site 1117943020402 catalytic residue [active] 1117943020403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1117943020404 putative substrate translocation pore; other site 1117943020405 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943020406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943020407 sequence-specific DNA binding site [nucleotide binding]; other site 1117943020408 salt bridge; other site 1117943020409 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1117943020410 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1117943020411 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1117943020412 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1117943020413 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1117943020414 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943020415 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943020416 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943020417 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1117943020418 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 1117943020419 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1117943020420 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1117943020421 Protein of unknown function, DUF269; Region: DUF269; cl03973 1117943020422 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1117943020423 probable nitrogen fixation protein; Region: TIGR02935 1117943020424 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 1117943020425 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1117943020426 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 1117943020427 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 1117943020428 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 1117943020429 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 1117943020430 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 1117943020431 MoFe protein beta/alpha subunit interactions; other site 1117943020432 Beta subunit P cluster binding residues; other site 1117943020433 MoFe protein beta subunit/Fe protein contacts; other site 1117943020434 MoFe protein dimer/ dimer interactions; other site 1117943020435 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 1117943020436 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 1117943020437 MoFe protein alpha/beta subunit interactions; other site 1117943020438 Alpha subunit P cluster binding residues; other site 1117943020439 FeMoco binding residues [chemical binding]; other site 1117943020440 MoFe protein alpha subunit/Fe protein contacts; other site 1117943020441 MoFe protein dimer/ dimer interactions; other site 1117943020442 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 1117943020443 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1117943020444 Nucleotide-binding sites [chemical binding]; other site 1117943020445 Walker A motif; other site 1117943020446 Switch I region of nucleotide binding site; other site 1117943020447 Fe4S4 binding sites [ion binding]; other site 1117943020448 Switch II region of nucleotide binding site; other site 1117943020449 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1117943020450 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1117943020451 short chain dehydrogenase; Validated; Region: PRK06484 1117943020452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1117943020453 NAD(P) binding site [chemical binding]; other site 1117943020454 active site 1117943020455 classical (c) SDRs; Region: SDR_c; cd05233 1117943020456 NAD(P) binding site [chemical binding]; other site 1117943020457 active site 1117943020458 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1117943020459 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1117943020460 Cytochrome P450; Region: p450; cl12078 1117943020461 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1117943020462 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1117943020463 NifQ; Region: NifQ; pfam04891 1117943020464 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1117943020465 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1117943020466 catalytic triad [active] 1117943020467 dimer interface [polypeptide binding]; other site 1117943020468 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1117943020469 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1117943020470 Ligand binding site [chemical binding]; other site 1117943020471 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1117943020472 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1117943020473 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1117943020474 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1117943020475 oxidoreductase; Provisional; Region: PRK10015 1117943020476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1117943020477 Nif-specific regulatory protein; Region: nifA; TIGR01817 1117943020478 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1117943020479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943020480 Walker A motif; other site 1117943020481 ATP binding site [chemical binding]; other site 1117943020482 Walker B motif; other site 1117943020483 arginine finger; other site 1117943020484 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1117943020485 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 1117943020486 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1117943020487 FeS/SAM binding site; other site 1117943020488 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 1117943020489 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1117943020490 Cell-cell adhesion domain; Region: Dicty_CAD; pfam05720 1117943020491 NifZ domain; Region: NifZ; pfam04319 1117943020492 NifT/FixU protein; Region: NifT; pfam06988 1117943020493 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1117943020494 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1117943020495 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943020496 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943020497 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1117943020498 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1117943020499 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1117943020500 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1117943020501 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1117943020502 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1117943020503 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1117943020504 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1117943020505 catalytic residue [active] 1117943020506 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810 1117943020507 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1117943020508 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943020509 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943020510 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943020511 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943020512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943020513 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943020514 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943020515 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943020516 Integrase core domain; Region: rve; pfam00665 1117943020517 transposase; Validated; Region: PRK08181 1117943020518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943020519 Walker A motif; other site 1117943020520 ATP binding site [chemical binding]; other site 1117943020521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943020522 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943020523 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943020524 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1117943020525 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943020526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943020527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1117943020528 Homeodomain-like domain; Region: HTH_23; cl17451 1117943020529 Putative transposase; Region: Y2_Tnp; pfam04986 1117943020530 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 1117943020531 Putative transposase; Region: Y2_Tnp; pfam04986 1117943020532 integron integrase; Region: integrase_gron; TIGR02249 1117943020533 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 1117943020534 Int/Topo IB signature motif; other site 1117943020535 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 1117943020536 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1117943020537 Transposase; Region: HTH_Tnp_1; pfam01527 1117943020538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943020539 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943020540 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1117943020541 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943020542 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943020543 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943020544 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943020545 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1117943020546 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1117943020547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943020548 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943020549 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943020550 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1117943020551 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1117943020552 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1117943020553 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943020554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943020555 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943020556 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1117943020557 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943020558 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943020559 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943020560 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943020561 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943020562 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1117943020563 active site 1117943020564 catalytic residues [active] 1117943020565 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1117943020566 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943020567 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943020568 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943020569 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943020570 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943020571 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943020572 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943020573 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943020574 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943020575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943020576 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943020577 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1117943020578 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 1117943020579 Int/Topo IB signature motif; other site 1117943020580 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943020581 active site 1117943020582 DNA binding site [nucleotide binding] 1117943020583 Int/Topo IB signature motif; other site 1117943020584 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943020585 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943020586 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1117943020587 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1117943020588 homotetramer interface [polypeptide binding]; other site 1117943020589 FMN binding site [chemical binding]; other site 1117943020590 homodimer contacts [polypeptide binding]; other site 1117943020591 putative active site [active] 1117943020592 putative substrate binding site [chemical binding]; other site 1117943020593 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1117943020594 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1117943020595 Cytochrome P450; Region: p450; cl12078 1117943020596 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1117943020597 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1117943020598 substrate binding pocket [chemical binding]; other site 1117943020599 chain length determination region; other site 1117943020600 substrate-Mg2+ binding site; other site 1117943020601 catalytic residues [active] 1117943020602 aspartate-rich region 1; other site 1117943020603 active site lid residues [active] 1117943020604 aspartate-rich region 2; other site 1117943020605 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1117943020606 Cytochrome P450; Region: p450; cl12078 1117943020607 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943020608 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943020609 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943020610 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943020611 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943020612 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943020613 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943020614 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943020615 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1117943020616 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1117943020617 Integrase core domain; Region: rve; pfam00665 1117943020618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1117943020619 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1117943020620 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1117943020621 putative active site [active] 1117943020622 putative NTP binding site [chemical binding]; other site 1117943020623 putative nucleic acid binding site [nucleotide binding]; other site 1117943020624 Putative transposase; Region: Y2_Tnp; pfam04986 1117943020625 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1117943020626 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1117943020627 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1117943020628 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1117943020629 nodulation factor exporter subunit NodI; Provisional; Region: PRK13536 1117943020630 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943020631 Walker A/P-loop; other site 1117943020632 ATP binding site [chemical binding]; other site 1117943020633 Q-loop/lid; other site 1117943020634 ABC transporter signature motif; other site 1117943020635 Walker B; other site 1117943020636 D-loop; other site 1117943020637 H-loop/switch region; other site 1117943020638 chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242 1117943020639 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1117943020640 DXD motif; other site 1117943020641 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1117943020642 chitooligosaccharide deacetylase NodB; Region: nodulat_NodB; TIGR04243 1117943020643 Nodulation protein A (NodA); Region: NodA; pfam02474 1117943020644 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 1117943020645 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943020646 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943020647 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943020648 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943020649 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943020650 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943020651 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943020652 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943020653 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1117943020654 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1117943020655 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1117943020656 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1117943020657 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943020658 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943020659 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1117943020660 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1117943020661 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1117943020662 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943020663 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943020664 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943020665 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943020666 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943020667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1117943020668 Transposase; Region: HTH_Tnp_1; pfam01527 1117943020669 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943020670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1117943020671 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943020672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943020673 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1117943020674 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943020675 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1117943020676 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1117943020677 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1117943020678 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1117943020679 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943020680 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943020681 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943020682 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943020683 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943020684 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943020685 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1117943020686 Transposase; Region: HTH_Tnp_1; pfam01527 1117943020687 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1117943020688 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943020689 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943020690 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943020691 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1117943020692 Transposase domain (DUF772); Region: DUF772; pfam05598 1117943020693 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943020694 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1117943020695 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1117943020696 MULE transposase domain; Region: MULE; pfam10551 1117943020697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1117943020698 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1117943020699 active site 1117943020700 Transposase domain (DUF772); Region: DUF772; pfam05598 1117943020701 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943020702 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1117943020703 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1117943020704 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1117943020705 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1117943020706 DNA binding residues [nucleotide binding] 1117943020707 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1117943020708 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1117943020709 HSP70 interaction site [polypeptide binding]; other site 1117943020710 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1117943020711 substrate binding site [polypeptide binding]; other site 1117943020712 dimer interface [polypeptide binding]; other site 1117943020713 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1117943020714 acetyl-CoA synthetase; Provisional; Region: PRK04319 1117943020715 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1117943020716 active site 1117943020717 acyl-activating enzyme (AAE) consensus motif; other site 1117943020718 putative CoA binding site [chemical binding]; other site 1117943020719 AMP binding site [chemical binding]; other site 1117943020720 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1117943020721 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1117943020722 tetramer interface [polypeptide binding]; other site 1117943020723 TPP-binding site [chemical binding]; other site 1117943020724 heterodimer interface [polypeptide binding]; other site 1117943020725 phosphorylation loop region [posttranslational modification] 1117943020726 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1117943020727 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1117943020728 alpha subunit interface [polypeptide binding]; other site 1117943020729 TPP binding site [chemical binding]; other site 1117943020730 heterodimer interface [polypeptide binding]; other site 1117943020731 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1117943020732 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1117943020733 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1117943020734 E3 interaction surface; other site 1117943020735 lipoyl attachment site [posttranslational modification]; other site 1117943020736 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1117943020737 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 1117943020738 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 1117943020739 FtsH Extracellular; Region: FtsH_ext; pfam06480 1117943020740 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1117943020741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1117943020742 Walker A motif; other site 1117943020743 ATP binding site [chemical binding]; other site 1117943020744 Walker B motif; other site 1117943020745 arginine finger; other site 1117943020746 Peptidase family M41; Region: Peptidase_M41; pfam01434 1117943020747 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1117943020748 Ligand Binding Site [chemical binding]; other site 1117943020749 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1117943020750 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1117943020751 active site 1117943020752 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1117943020753 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1117943020754 putative dimer interface [polypeptide binding]; other site 1117943020755 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1117943020756 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1117943020757 active site 1117943020758 CoA binding site [chemical binding]; other site 1117943020759 AMP binding site [chemical binding]; other site 1117943020760 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1117943020761 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1117943020762 putative acyl-acceptor binding pocket; other site 1117943020763 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1117943020764 hypothetical protein; Provisional; Region: PRK08609 1117943020765 active site 1117943020766 primer binding site [nucleotide binding]; other site 1117943020767 NTP binding site [chemical binding]; other site 1117943020768 metal binding triad [ion binding]; metal-binding site 1117943020769 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1117943020770 active site 1117943020771 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1117943020772 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1117943020773 active site 1117943020774 Protein required for attachment to host cells; Region: Host_attach; pfam10116 1117943020775 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1117943020776 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1117943020777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943020778 Walker A/P-loop; other site 1117943020779 ATP binding site [chemical binding]; other site 1117943020780 Q-loop/lid; other site 1117943020781 ABC transporter signature motif; other site 1117943020782 Walker B; other site 1117943020783 D-loop; other site 1117943020784 H-loop/switch region; other site 1117943020785 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1117943020786 BON domain; Region: BON; pfam04972 1117943020787 BON domain; Region: BON; pfam04972 1117943020788 BON domain; Region: BON; pfam04972 1117943020789 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1117943020790 BON domain; Region: BON; pfam04972 1117943020791 BON domain; Region: BON; pfam04972 1117943020792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1117943020793 Predicted kinase [General function prediction only]; Region: COG0645 1117943020794 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1117943020795 active site 1117943020796 Glucokinase; Region: Glucokinase; cl17310 1117943020797 glucokinase, proteobacterial type; Region: glk; TIGR00749 1117943020798 Protein required for attachment to host cells; Region: Host_attach; pfam10116 1117943020799 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1117943020800 Peptidase family M50; Region: Peptidase_M50; pfam02163 1117943020801 active site 1117943020802 putative substrate binding region [chemical binding]; other site 1117943020803 FOG: CBS domain [General function prediction only]; Region: COG0517 1117943020804 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639 1117943020805 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1117943020806 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1117943020807 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943020808 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943020809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943020810 intermolecular recognition site; other site 1117943020811 active site 1117943020812 dimerization interface [polypeptide binding]; other site 1117943020813 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943020814 DNA binding site [nucleotide binding] 1117943020815 BON domain; Region: BON; pfam04972 1117943020816 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1117943020817 BON domain; Region: BON; pfam04972 1117943020818 BON domain; Region: BON; pfam04972 1117943020819 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 1117943020820 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1117943020821 30S subunit binding site; other site 1117943020822 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1117943020823 DNA-binding site [nucleotide binding]; DNA binding site 1117943020824 RNA-binding motif; other site 1117943020825 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1117943020826 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1117943020827 ligand binding site [chemical binding]; other site 1117943020828 flexible hinge region; other site 1117943020829 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1117943020830 putative switch regulator; other site 1117943020831 non-specific DNA interactions [nucleotide binding]; other site 1117943020832 DNA binding site [nucleotide binding] 1117943020833 sequence specific DNA binding site [nucleotide binding]; other site 1117943020834 putative cAMP binding site [chemical binding]; other site 1117943020835 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1117943020836 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1117943020837 ligand binding site [chemical binding]; other site 1117943020838 flexible hinge region; other site 1117943020839 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1117943020840 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943020841 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1117943020842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943020843 motif II; other site 1117943020844 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1117943020845 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1117943020846 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1117943020847 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943020848 Glycerate kinase family; Region: Gly_kinase; cl00841 1117943020849 ChaB; Region: ChaB; pfam06150 1117943020850 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1117943020851 active site 1117943020852 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1117943020853 Putative glucoamylase; Region: Glycoamylase; pfam10091 1117943020854 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 1117943020855 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1117943020856 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 1117943020857 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1117943020858 Ligand Binding Site [chemical binding]; other site 1117943020859 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1117943020860 Ligand Binding Site [chemical binding]; other site 1117943020861 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1117943020862 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1117943020863 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1117943020864 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1117943020865 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1117943020866 catalytic residue [active] 1117943020867 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1117943020868 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943020869 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1117943020870 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1117943020871 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943020872 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1117943020873 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1117943020874 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1117943020875 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1117943020876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1117943020877 dimer interface [polypeptide binding]; other site 1117943020878 conserved gate region; other site 1117943020879 putative PBP binding loops; other site 1117943020880 ABC-ATPase subunit interface; other site 1117943020881 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1117943020882 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1117943020883 Walker A/P-loop; other site 1117943020884 ATP binding site [chemical binding]; other site 1117943020885 Q-loop/lid; other site 1117943020886 ABC transporter signature motif; other site 1117943020887 Walker B; other site 1117943020888 D-loop; other site 1117943020889 H-loop/switch region; other site 1117943020890 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1117943020891 NMT1-like family; Region: NMT1_2; pfam13379 1117943020892 substrate binding pocket [chemical binding]; other site 1117943020893 membrane-bound complex binding site; other site 1117943020894 hinge residues; other site 1117943020895 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1117943020896 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1117943020897 putative substrate binding site [chemical binding]; other site 1117943020898 putative ATP binding site [chemical binding]; other site 1117943020899 FOG: CBS domain [General function prediction only]; Region: COG0517 1117943020900 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 1117943020901 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 1117943020902 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1117943020903 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1117943020904 active site 1117943020905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1117943020906 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1117943020907 Ligand Binding Site [chemical binding]; other site 1117943020908 chaperonin GroEL; Reviewed; Region: groEL; PRK12851 1117943020909 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1117943020910 ring oligomerisation interface [polypeptide binding]; other site 1117943020911 ATP/Mg binding site [chemical binding]; other site 1117943020912 stacking interactions; other site 1117943020913 hinge regions; other site 1117943020914 Domain of unknown function (DUF1476); Region: DUF1476; cl11571 1117943020915 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1117943020916 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1117943020917 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1117943020918 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1117943020919 Glucokinase; Region: Glucokinase; cl17310 1117943020920 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1117943020921 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1117943020922 putative dimer interface [polypeptide binding]; other site 1117943020923 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1117943020924 Ligand Binding Site [chemical binding]; other site 1117943020925 Protein required for attachment to host cells; Region: Host_attach; pfam10116 1117943020926 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1117943020927 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1117943020928 Walker A/P-loop; other site 1117943020929 ATP binding site [chemical binding]; other site 1117943020930 Q-loop/lid; other site 1117943020931 ABC transporter signature motif; other site 1117943020932 Walker B; other site 1117943020933 D-loop; other site 1117943020934 H-loop/switch region; other site 1117943020935 FtsX-like permease family; Region: FtsX; pfam02687 1117943020936 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1117943020937 FtsX-like permease family; Region: FtsX; pfam02687 1117943020938 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1117943020939 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943020940 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1117943020941 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1117943020942 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943020943 protein binding site [polypeptide binding]; other site 1117943020944 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1117943020945 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1117943020946 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1117943020947 Beta-Casp domain; Region: Beta-Casp; smart01027 1117943020948 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1117943020949 ornithine carbamoyltransferase; Validated; Region: PRK02102 1117943020950 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1117943020951 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1117943020952 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1117943020953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943020954 active site 1117943020955 phosphorylation site [posttranslational modification] 1117943020956 intermolecular recognition site; other site 1117943020957 dimerization interface [polypeptide binding]; other site 1117943020958 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1117943020959 DNA binding site [nucleotide binding] 1117943020960 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 1117943020961 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1117943020962 ligand binding site [chemical binding]; other site 1117943020963 flexible hinge region; other site 1117943020964 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1117943020965 putative switch regulator; other site 1117943020966 non-specific DNA interactions [nucleotide binding]; other site 1117943020967 DNA binding site [nucleotide binding] 1117943020968 sequence specific DNA binding site [nucleotide binding]; other site 1117943020969 putative cAMP binding site [chemical binding]; other site 1117943020970 PAS fold; Region: PAS_4; pfam08448 1117943020971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943020972 putative active site [active] 1117943020973 heme pocket [chemical binding]; other site 1117943020974 PAS domain S-box; Region: sensory_box; TIGR00229 1117943020975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1117943020976 putative active site [active] 1117943020977 heme pocket [chemical binding]; other site 1117943020978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1117943020979 dimer interface [polypeptide binding]; other site 1117943020980 phosphorylation site [posttranslational modification] 1117943020981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1117943020982 ATP binding site [chemical binding]; other site 1117943020983 G-X-G motif; other site 1117943020984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1117943020985 phosphorylation site [posttranslational modification] 1117943020986 intermolecular recognition site; other site 1117943020987 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1117943020988 magnesium-transporting ATPase; Provisional; Region: PRK15122 1117943020989 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943020990 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1117943020991 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1117943020992 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1117943020993 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1117943020994 CoA binding domain; Region: CoA_binding_2; pfam13380 1117943020995 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1117943020996 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1117943020997 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1117943020998 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1117943020999 Ligand Binding Site [chemical binding]; other site 1117943021000 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1117943021001 Ligand Binding Site [chemical binding]; other site 1117943021002 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 1117943021003 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1117943021004 BON domain; Region: BON; pfam04972 1117943021005 BON domain; Region: BON; pfam04972 1117943021006 BON domain; Region: BON; pfam04972 1117943021007 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1117943021008 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1117943021009 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943021010 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1117943021011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1117943021012 motif II; other site 1117943021013 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1117943021014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1117943021015 Predicted kinase [General function prediction only]; Region: COG0645 1117943021016 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1117943021017 active site 1117943021018 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1117943021019 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1117943021020 active site 1117943021021 Predicted membrane protein [Function unknown]; Region: COG3174 1117943021022 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 1117943021023 Predicted membrane protein [Function unknown]; Region: COG3619 1117943021024 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1117943021025 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1117943021026 Hemerythrin-like domain; Region: Hr-like; cd12108 1117943021027 Fe binding site [ion binding]; other site 1117943021028 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1117943021029 TAP-like protein; Region: Abhydrolase_4; pfam08386 1117943021030 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1117943021031 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1117943021032 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1117943021033 Cytochrome c; Region: Cytochrom_C; pfam00034 1117943021034 Predicted transporter component [General function prediction only]; Region: COG2391 1117943021035 Sulphur transport; Region: Sulf_transp; pfam04143 1117943021036 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1117943021037 HlyD family secretion protein; Region: HlyD_3; pfam13437 1117943021038 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1117943021039 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1117943021040 FtsX-like permease family; Region: FtsX; pfam02687 1117943021041 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1117943021042 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1117943021043 FtsX-like permease family; Region: FtsX; pfam02687 1117943021044 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943021045 ABC transporter signature motif; other site 1117943021046 Walker B; other site 1117943021047 D-loop; other site 1117943021048 H-loop/switch region; other site 1117943021049 LTXXQ motif family protein; Region: LTXXQ; pfam07813 1117943021050 putative phosphoketolase; Provisional; Region: PRK05261 1117943021051 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1117943021052 TPP-binding site; other site 1117943021053 XFP C-terminal domain; Region: XFP_C; pfam09363 1117943021054 FOG: CBS domain [General function prediction only]; Region: COG0517 1117943021055 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 1117943021056 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1117943021057 BON domain; Region: BON; pfam04972 1117943021058 ABC1 family; Region: ABC1; cl17513 1117943021059 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1117943021060 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 1117943021061 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1117943021062 Walker A motif; other site 1117943021063 hexamer interface [polypeptide binding]; other site 1117943021064 ATP binding site [chemical binding]; other site 1117943021065 Walker B motif; other site 1117943021066 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 1117943021067 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1117943021068 VirB7 interaction site; other site 1117943021069 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 1117943021070 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 1117943021071 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 1117943021072 Type IV secretion system proteins; Region: T4SS; pfam07996 1117943021073 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 1117943021074 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1117943021075 Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702 1117943021076 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 1117943021077 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1117943021078 MarR family; Region: MarR_2; cl17246 1117943021079 Autoinducer synthetase; Region: Autoind_synth; cl17404 1117943021080 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 1117943021081 MerR family regulatory protein; Region: MerR; pfam00376 1117943021082 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1117943021083 P-loop; other site 1117943021084 Magnesium ion binding site [ion binding]; other site 1117943021085 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 1117943021086 ParB-like nuclease domain; Region: ParB; smart00470 1117943021087 replication initiation protein RepC; Provisional; Region: PRK13824 1117943021088 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1117943021089 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 1117943021090 LabA_like proteins; Region: LabA_like/DUF88; cl10034 1117943021091 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1117943021092 putative metal binding site [ion binding]; other site 1117943021093 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 1117943021094 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1117943021095 DNA-binding site [nucleotide binding]; DNA binding site 1117943021096 RNA-binding motif; other site 1117943021097 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1117943021098 Int/Topo IB signature motif; other site 1117943021099 DNA binding site [nucleotide binding] 1117943021100 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 1117943021101 HTH DNA binding domain; Region: HTH_13; pfam11972 1117943021102 Competence protein CoiA-like family; Region: CoiA; cl11541 1117943021103 Superfamily II helicase [General function prediction only]; Region: COG1204 1117943021104 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1117943021105 ATP binding site [chemical binding]; other site 1117943021106 putative Mg++ binding site [ion binding]; other site 1117943021107 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 1117943021108 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1117943021109 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1117943021110 AAA domain; Region: AAA_11; pfam13086 1117943021111 Part of AAA domain; Region: AAA_19; pfam13245 1117943021112 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1117943021113 AAA domain; Region: AAA_12; pfam13087 1117943021114 MarR family; Region: MarR_2; pfam12802 1117943021115 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 1117943021116 PLD-like domain; Region: PLDc_2; pfam13091 1117943021117 putative active site [active] 1117943021118 putative catalytic site [active] 1117943021119 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 1117943021120 PLD-like domain; Region: PLDc_2; pfam13091 1117943021121 putative active site [active] 1117943021122 putative catalytic site [active] 1117943021123 Part of AAA domain; Region: AAA_19; pfam13245 1117943021124 Family description; Region: UvrD_C_2; pfam13538 1117943021125 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1117943021126 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1117943021127 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 1117943021128 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1117943021129 active site 1117943021130 substrate binding site [chemical binding]; other site 1117943021131 catalytic site [active] 1117943021132 Protein of unknown function (DUF429); Region: DUF429; cl12046 1117943021133 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1117943021134 ATP binding site [chemical binding]; other site 1117943021135 putative Mg++ binding site [ion binding]; other site 1117943021136 nucleotide binding region [chemical binding]; other site 1117943021137 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1117943021138 ATP-binding site [chemical binding]; other site 1117943021139 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1117943021140 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1117943021141 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1117943021142 active site 1117943021143 DNA polymerase IV; Validated; Region: PRK02406 1117943021144 DNA binding site [nucleotide binding] 1117943021145 Uncharacterized conserved protein [Function unknown]; Region: COG4544 1117943021146 DNA Polymerase Y-family; Region: PolY_like; cd03468 1117943021147 active site 1117943021148 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1117943021149 DNA binding site [nucleotide binding] 1117943021150 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1117943021151 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1117943021152 putative active site [active] 1117943021153 putative PHP Thumb interface [polypeptide binding]; other site 1117943021154 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1117943021155 generic binding surface I; other site 1117943021156 generic binding surface II; other site 1117943021157 Helix-turn-helix domain; Region: HTH_17; cl17695 1117943021158 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1117943021159 ParB-like nuclease domain; Region: ParBc; pfam02195 1117943021160 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1117943021161 Antirestriction protein; Region: Antirestrict; pfam03230 1117943021162 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 1117943021163 YodA lipocalin-like domain; Region: YodA; pfam09223 1117943021164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1117943021165 S-adenosylmethionine binding site [chemical binding]; other site 1117943021166 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1117943021167 ATP binding site [chemical binding]; other site 1117943021168 putative Mg++ binding site [ion binding]; other site 1117943021169 Helicase_C-like; Region: Helicase_C_4; pfam13871 1117943021170 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1117943021171 active site 1117943021172 metal binding site [ion binding]; metal-binding site 1117943021173 interdomain interaction site; other site 1117943021174 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 1117943021175 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1117943021176 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1117943021177 putative active site [active] 1117943021178 Uncharacterized conserved protein [Function unknown]; Region: COG5489 1117943021179 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1117943021180 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 1117943021181 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 1117943021182 Walker A motif; other site 1117943021183 ATP binding site [chemical binding]; other site 1117943021184 Walker B motif; other site 1117943021185 Conjugal transfer protein TraD; Region: TraD; pfam06412 1117943021186 TraC-like protein; Region: TraC; pfam07820 1117943021187 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 1117943021188 MobA/MobL family; Region: MobA_MobL; pfam03389 1117943021189 AAA domain; Region: AAA_30; pfam13604 1117943021190 Family description; Region: UvrD_C_2; pfam13538 1117943021191 Zeta toxin; Region: Zeta_toxin; pfam06414 1117943021192 XK-related protein; Region: XK-related; pfam09815 1117943021193 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1117943021194 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1117943021195 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1117943021196 HWE histidine kinase; Region: HWE_HK; smart00911 1117943021197 Domain of unknown function DUF302; Region: DUF302; pfam03625 1117943021198 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1117943021199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943021200 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943021201 Protein of unknown function (DUF1515); Region: DUF1515; pfam07439 1117943021202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943021203 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943021204 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1117943021205 Transposase domain (DUF772); Region: DUF772; pfam05598 1117943021206 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943021207 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1117943021208 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1117943021209 MULE transposase domain; Region: MULE; pfam10551 1117943021210 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1117943021211 Integrase core domain; Region: rve; pfam00665 1117943021212 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1117943021213 Bacterial TniB protein; Region: TniB; pfam05621 1117943021214 AAA domain; Region: AAA_22; pfam13401 1117943021215 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1117943021216 Restriction endonuclease; Region: Mrr_cat; pfam04471 1117943021217 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943021218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1117943021219 Integrase core domain; Region: rve; pfam00665 1117943021220 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1117943021221 Leucine rich repeat; Region: LRR_8; pfam13855 1117943021222 Leucine-rich repeats; other site 1117943021223 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1117943021224 Leucine rich repeat; Region: LRR_8; pfam13855 1117943021225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1117943021226 Integrase core domain; Region: rve; pfam00665 1117943021227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1117943021230 AAA domain; Region: AAA_23; pfam13476 1117943021231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943021232 Walker A/P-loop; other site 1117943021233 ATP binding site [chemical binding]; other site 1117943021234 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 1117943021235 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943021236 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1117943021237 Integrase core domain; Region: rve; pfam00665 1117943021238 Phasin protein; Region: Phasin_2; cl11491 1117943021239 Transposase; Region: HTH_Tnp_1; cl17663 1117943021240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1117943021241 HTH-like domain; Region: HTH_21; pfam13276 1117943021242 Integrase core domain; Region: rve; pfam00665 1117943021243 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1117943021244 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1117943021245 Homeodomain-like domain; Region: HTH_23; pfam13384 1117943021246 Winged helix-turn helix; Region: HTH_29; pfam13551 1117943021247 Winged helix-turn helix; Region: HTH_33; pfam13592 1117943021248 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1117943021249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1117943021250 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1117943021251 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1117943021252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1117943021253 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1117943021254 MULE transposase domain; Region: MULE; pfam10551 1117943021255 Transposase domain (DUF772); Region: DUF772; pfam05598 1117943021256 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1117943021257 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1117943021258 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1117943021259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1117943021260 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1117943021261 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1117943021262 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1117943021263 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1117943021264 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1117943021265 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1117943021266 Integrase core domain; Region: rve; pfam00665 1117943021267 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1117943021268 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1117943021269 Homeodomain-like domain; Region: HTH_32; pfam13565 1117943021270 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1117943021271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1117943021272 non-specific DNA binding site [nucleotide binding]; other site 1117943021273 salt bridge; other site 1117943021274 sequence-specific DNA binding site [nucleotide binding]; other site 1117943021275 Prokaryotic Transcriptional repressor TraM; Region: Prok-TraM; pfam09228 1117943021276 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1117943021277 DNA binding residues [nucleotide binding] 1117943021278 dimerization interface [polypeptide binding]; other site 1117943021279 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1117943021280 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 1117943021281 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 1117943021282 conjugal transfer protein TrbH; Provisional; Region: PRK13835 1117943021283 Conjugal transfer protein TrbH; Region: TrbH; pfam07283 1117943021284 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1117943021285 VirB7 interaction site; other site 1117943021286 conjugal transfer protein TrbF; Provisional; Region: PRK13836 1117943021287 conjugal transfer protein TrbL; Provisional; Region: PRK13841 1117943021288 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 1117943021289 Protein of unknown function (DUF2749); Region: DUF2749; pfam10907 1117943021290 conjugal transfer protein TrbJ; Provisional; Region: PRK13842 1117943021291 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 1117943021292 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1117943021293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943021294 AAA-like domain; Region: AAA_10; pfam12846 1117943021295 Walker A/P-loop; other site 1117943021296 ATP binding site [chemical binding]; other site 1117943021297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1117943021298 Walker B; other site 1117943021299 D-loop; other site 1117943021300 H-loop/switch region; other site 1117943021301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1117943021302 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1117943021303 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1117943021304 conjugal transfer protein TrbE; Provisional; Region: PRK13830 1117943021305 conjugal transfer protein TrbD; Provisional; Region: PRK13823 1117943021306 conjugal transfer protein TrbC; Provisional; Region: PRK13871 1117943021307 conjugal transfer protein TrbB; Provisional; Region: PRK13833 1117943021308 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1117943021309 ATP binding site [chemical binding]; other site 1117943021310 Walker A motif; other site 1117943021311 hexamer interface [polypeptide binding]; other site 1117943021312 Walker B motif; other site 1117943021313 putative autoinducer synthesis protein; Provisional; Region: PRK13834 1117943021314 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 1117943021315 MerR family regulatory protein; Region: MerR; pfam00376 1117943021316 DNA binding residues [nucleotide binding] 1117943021317 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1117943021318 P-loop; other site 1117943021319 Magnesium ion binding site [ion binding]; other site 1117943021320 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1117943021321 Magnesium ion binding site [ion binding]; other site 1117943021322 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 1117943021323 ParB-like nuclease domain; Region: ParB; smart00470 1117943021324 replication initiation protein RepC; Provisional; Region: PRK13824 1117943021325 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1117943021326 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 1117943021327 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1117943021328 DNA-binding site [nucleotide binding]; DNA binding site 1117943021329 RNA-binding motif; other site 1117943021330 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1117943021331 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1117943021332 catalytic residues [active] 1117943021333 catalytic nucleophile [active] 1117943021334 Presynaptic Site I dimer interface [polypeptide binding]; other site 1117943021335 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1117943021336 Synaptic Flat tetramer interface [polypeptide binding]; other site 1117943021337 Synaptic Site I dimer interface [polypeptide binding]; other site 1117943021338 DNA binding site [nucleotide binding] 1117943021339 Permease; Region: Permease; cl00510 1117943021340 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1117943021341 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1117943021342 FeS/SAM binding site; other site 1117943021343 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 1117943021344 Agmatinase-like family; Region: Agmatinase-like; cd09990 1117943021345 active site 1117943021346 oligomer interface [polypeptide binding]; other site 1117943021347 ATP-grasp domain; Region: ATP-grasp_4; pfam13535