-- dump date   	20140620_070044
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1185652000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1185652000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
1185652000003	Bacterial dnaA protein; Region: Bac_DnaA; pfam00308
1185652000004	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1185652000005	DnaA box-binding interface [nucleotide binding]; other site
1185652000006	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
1185652000007	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
1185652000008	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1185652000009	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1185652000010	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
1185652000011	putative hydrophobic ligand binding site [chemical binding]; other site
1185652000012	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
1185652000013	SnoaL-like domain; Region: SnoaL_3; pfam13474
1185652000014	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
1185652000015	putative dimer interface [polypeptide binding]; other site
1185652000016	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652000017	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1185652000018	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
1185652000019	putative C-terminal domain interface [polypeptide binding]; other site
1185652000020	putative GSH binding site (G-site) [chemical binding]; other site
1185652000021	putative dimer interface [polypeptide binding]; other site
1185652000022	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
1185652000023	dimer interface [polypeptide binding]; other site
1185652000024	N-terminal domain interface [polypeptide binding]; other site
1185652000025	putative substrate binding pocket (H-site) [chemical binding]; other site
1185652000026	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
1185652000027	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1185652000028	FeS/SAM binding site; other site
1185652000029	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1185652000030	active site
1185652000031	dimerization interface [polypeptide binding]; other site
1185652000032	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354
1185652000033	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652000034	ribonuclease PH; Reviewed; Region: rph; PRK00173
1185652000035	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1185652000036	hexamer interface [polypeptide binding]; other site
1185652000037	active site
1185652000038	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1185652000039	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1185652000040	heat shock protein GrpE; Provisional; Region: PRK14141
1185652000041	dimer interface [polypeptide binding]; other site
1185652000042	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1185652000043	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
1185652000044	FAD binding domain; Region: FAD_binding_4; pfam01565
1185652000045	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1185652000046	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1185652000047	classical (c) SDRs; Region: SDR_c; cd05233
1185652000048	NAD(P) binding site [chemical binding]; other site
1185652000049	active site
1185652000050	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1185652000051	active site
1185652000052	phosphorylation site [posttranslational modification]
1185652000053	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1185652000054	30S subunit binding site; other site
1185652000055	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
1185652000056	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1185652000057	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1185652000058	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1185652000059	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1185652000060	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1185652000061	Walker A/P-loop; other site
1185652000062	ATP binding site [chemical binding]; other site
1185652000063	Q-loop/lid; other site
1185652000064	ABC transporter signature motif; other site
1185652000065	Walker B; other site
1185652000066	D-loop; other site
1185652000067	H-loop/switch region; other site
1185652000068	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
1185652000069	OstA-like protein; Region: OstA; pfam03968
1185652000070	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
1185652000071	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1185652000072	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1185652000073	tandem repeat interface [polypeptide binding]; other site
1185652000074	oligomer interface [polypeptide binding]; other site
1185652000075	active site residues [active]
1185652000076	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1185652000077	IHF dimer interface [polypeptide binding]; other site
1185652000078	IHF - DNA interface [nucleotide binding]; other site
1185652000079	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
1185652000080	putative hydrophobic ligand binding site [chemical binding]; other site
1185652000081	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1185652000082	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652000083	S-adenosylmethionine binding site [chemical binding]; other site
1185652000084	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1185652000085	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1185652000086	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1185652000087	lipoprotein signal peptidase; Provisional; Region: PRK14795
1185652000088	lipoprotein signal peptidase; Provisional; Region: PRK14787
1185652000089	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652000090	dimer interface [polypeptide binding]; other site
1185652000091	phosphorylation site [posttranslational modification]
1185652000092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652000093	ATP binding site [chemical binding]; other site
1185652000094	Mg2+ binding site [ion binding]; other site
1185652000095	G-X-G motif; other site
1185652000096	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1185652000097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652000098	active site
1185652000099	phosphorylation site [posttranslational modification]
1185652000100	intermolecular recognition site; other site
1185652000101	dimerization interface [polypeptide binding]; other site
1185652000102	Putative hemolysin [General function prediction only]; Region: COG3176
1185652000103	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
1185652000104	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1185652000105	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1185652000106	putative NAD(P) binding site [chemical binding]; other site
1185652000107	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1185652000108	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1185652000109	MutS domain I; Region: MutS_I; pfam01624
1185652000110	MutS domain II; Region: MutS_II; pfam05188
1185652000111	MutS domain III; Region: MutS_III; pfam05192
1185652000112	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1185652000113	Walker A/P-loop; other site
1185652000114	ATP binding site [chemical binding]; other site
1185652000115	Q-loop/lid; other site
1185652000116	ABC transporter signature motif; other site
1185652000117	Walker B; other site
1185652000118	D-loop; other site
1185652000119	H-loop/switch region; other site
1185652000120	PII uridylyl-transferase; Provisional; Region: PRK05092
1185652000121	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1185652000122	metal binding triad; other site
1185652000123	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1185652000124	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1185652000125	Zn2+ binding site [ion binding]; other site
1185652000126	Mg2+ binding site [ion binding]; other site
1185652000127	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
1185652000128	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
1185652000129	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1185652000130	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1185652000131	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1185652000132	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1185652000133	active site
1185652000134	HIGH motif; other site
1185652000135	dimer interface [polypeptide binding]; other site
1185652000136	KMSKS motif; other site
1185652000137	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1185652000138	Ligand Binding Site [chemical binding]; other site
1185652000139	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
1185652000140	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1185652000141	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
1185652000142	Glycoprotease family; Region: Peptidase_M22; pfam00814
1185652000143	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1185652000144	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652000145	Coenzyme A binding pocket [chemical binding]; other site
1185652000146	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1185652000147	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1185652000148	putative acyl-acceptor binding pocket; other site
1185652000149	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
1185652000150	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1185652000151	TRAM domain; Region: TRAM; pfam01938
1185652000152	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1185652000153	PhoH-like protein; Region: PhoH; pfam02562
1185652000154	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
1185652000155	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1185652000156	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1185652000157	Transporter associated domain; Region: CorC_HlyC; smart01091
1185652000158	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1185652000159	LabA_like proteins; Region: LabA; cd10911
1185652000160	putative metal binding site [ion binding]; other site
1185652000161	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1185652000162	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1185652000163	putative active site [active]
1185652000164	catalytic triad [active]
1185652000165	putative dimer interface [polypeptide binding]; other site
1185652000166	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1185652000167	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652000168	non-specific DNA binding site [nucleotide binding]; other site
1185652000169	salt bridge; other site
1185652000170	sequence-specific DNA binding site [nucleotide binding]; other site
1185652000171	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1185652000172	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1185652000173	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1185652000174	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1185652000175	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652000176	S-adenosylmethionine binding site [chemical binding]; other site
1185652000177	Uncharacterized small protein [Function unknown]; Region: COG5568
1185652000178	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1185652000179	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1185652000180	putative dimer interface [polypeptide binding]; other site
1185652000181	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1185652000182	active site
1185652000183	tetramer interface [polypeptide binding]; other site
1185652000184	Cache domain; Region: Cache_1; pfam02743
1185652000185	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1185652000186	dimerization interface [polypeptide binding]; other site
1185652000187	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1185652000188	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1185652000189	dimer interface [polypeptide binding]; other site
1185652000190	putative CheW interface [polypeptide binding]; other site
1185652000191	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1185652000192	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1185652000193	substrate binding site [chemical binding]; other site
1185652000194	dimer interface [polypeptide binding]; other site
1185652000195	ATP binding site [chemical binding]; other site
1185652000196	RmuC family; Region: RmuC; pfam02646
1185652000197	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1185652000198	active site
1185652000199	catalytic residues [active]
1185652000200	metal binding site [ion binding]; metal-binding site
1185652000201	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1185652000202	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1185652000203	putative active site [active]
1185652000204	substrate binding site [chemical binding]; other site
1185652000205	putative cosubstrate binding site; other site
1185652000206	catalytic site [active]
1185652000207	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1185652000208	substrate binding site [chemical binding]; other site
1185652000209	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1185652000210	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1185652000211	dimerization interface 3.5A [polypeptide binding]; other site
1185652000212	active site
1185652000213	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
1185652000214	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
1185652000215	metal binding site [ion binding]; metal-binding site
1185652000216	dimer interface [polypeptide binding]; other site
1185652000217	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
1185652000218	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1185652000219	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1185652000220	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652000221	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1185652000222	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652000223	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652000224	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1185652000225	putative effector binding pocket; other site
1185652000226	putative dimerization interface [polypeptide binding]; other site
1185652000227	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1185652000228	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1185652000229	ATP binding site [chemical binding]; other site
1185652000230	Mg++ binding site [ion binding]; other site
1185652000231	motif III; other site
1185652000232	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1185652000233	nucleotide binding region [chemical binding]; other site
1185652000234	ATP-binding site [chemical binding]; other site
1185652000235	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
1185652000236	RNA binding site [nucleotide binding]; other site
1185652000237	Predicted membrane protein [Function unknown]; Region: COG3152
1185652000238	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
1185652000239	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1185652000240	trimer interface [polypeptide binding]; other site
1185652000241	active site
1185652000242	substrate binding site [chemical binding]; other site
1185652000243	CoA binding site [chemical binding]; other site
1185652000244	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1185652000245	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
1185652000246	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1185652000247	motif II; other site
1185652000248	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
1185652000249	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1185652000250	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1185652000251	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1185652000252	DNA binding site [nucleotide binding]
1185652000253	active site
1185652000254	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1185652000255	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1185652000256	tetramer interface [polypeptide binding]; other site
1185652000257	active site
1185652000258	Mg2+/Mn2+ binding site [ion binding]; other site
1185652000259	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1185652000260	homohexameric interface [polypeptide binding]; other site
1185652000261	feedback inhibition sensing region; other site
1185652000262	carbamate kinase; Reviewed; Region: PRK12686
1185652000263	nucleotide binding site [chemical binding]; other site
1185652000264	N-acetyl-L-glutamate binding site [chemical binding]; other site
1185652000265	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
1185652000266	Anti-sigma-K factor rskA; Region: RskA; pfam10099
1185652000267	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
1185652000268	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1185652000269	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
1185652000270	G1 box; other site
1185652000271	GTP/Mg2+ binding site [chemical binding]; other site
1185652000272	Switch I region; other site
1185652000273	G2 box; other site
1185652000274	G3 box; other site
1185652000275	Switch II region; other site
1185652000276	G4 box; other site
1185652000277	G5 box; other site
1185652000278	membrane protein insertase; Provisional; Region: PRK01318
1185652000279	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1185652000280	ribonuclease P; Reviewed; Region: rnpA; PRK01313
1185652000281	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1185652000282	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1185652000283	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1185652000284	dimer interface [polypeptide binding]; other site
1185652000285	putative CheW interface [polypeptide binding]; other site
1185652000286	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1185652000287	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1185652000288	mercuric reductase; Validated; Region: PRK06370
1185652000289	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652000290	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1185652000291	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652000292	HAMP domain; Region: HAMP; pfam00672
1185652000293	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652000294	ATP binding site [chemical binding]; other site
1185652000295	Mg2+ binding site [ion binding]; other site
1185652000296	G-X-G motif; other site
1185652000297	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
1185652000298	putative deacylase active site [active]
1185652000299	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1185652000300	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
1185652000301	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1185652000302	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1185652000303	active site
1185652000304	catalytic tetrad [active]
1185652000305	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1185652000306	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1185652000307	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1185652000308	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
1185652000309	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1185652000310	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
1185652000311	Glutamate binding site [chemical binding]; other site
1185652000312	NAD binding site [chemical binding]; other site
1185652000313	catalytic residues [active]
1185652000314	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1185652000315	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
1185652000316	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1185652000317	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1185652000318	active site
1185652000319	metal binding site [ion binding]; metal-binding site
1185652000320	hexamer interface [polypeptide binding]; other site
1185652000321	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
1185652000322	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1185652000323	FecR protein; Region: FecR; pfam04773
1185652000324	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
1185652000325	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
1185652000326	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652000327	cyclase homology domain; Region: CHD; cd07302
1185652000328	nucleotidyl binding site; other site
1185652000329	metal binding site [ion binding]; metal-binding site
1185652000330	dimer interface [polypeptide binding]; other site
1185652000331	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1185652000332	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1185652000333	ligand binding site [chemical binding]; other site
1185652000334	flexible hinge region; other site
1185652000335	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1185652000336	putative switch regulator; other site
1185652000337	non-specific DNA interactions [nucleotide binding]; other site
1185652000338	DNA binding site [nucleotide binding]
1185652000339	sequence specific DNA binding site [nucleotide binding]; other site
1185652000340	putative cAMP binding site [chemical binding]; other site
1185652000341	Predicted membrane protein [Function unknown]; Region: COG2259
1185652000342	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
1185652000343	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1185652000344	non-specific DNA interactions [nucleotide binding]; other site
1185652000345	DNA binding site [nucleotide binding]
1185652000346	sequence specific DNA binding site [nucleotide binding]; other site
1185652000347	putative cAMP binding site [chemical binding]; other site
1185652000348	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1185652000349	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1185652000350	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1185652000351	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1185652000352	ligand binding site [chemical binding]; other site
1185652000353	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652000354	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652000355	TM-ABC transporter signature motif; other site
1185652000356	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1185652000357	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652000358	Walker A/P-loop; other site
1185652000359	ATP binding site [chemical binding]; other site
1185652000360	Q-loop/lid; other site
1185652000361	ABC transporter signature motif; other site
1185652000362	Walker B; other site
1185652000363	D-loop; other site
1185652000364	H-loop/switch region; other site
1185652000365	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
1185652000366	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1185652000367	active site
1185652000368	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
1185652000369	active site
1185652000370	substrate binding pocket [chemical binding]; other site
1185652000371	dimer interface [polypeptide binding]; other site
1185652000372	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1185652000373	active site
1185652000374	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1185652000375	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1185652000376	putative substrate binding site [chemical binding]; other site
1185652000377	putative ATP binding site [chemical binding]; other site
1185652000378	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1185652000379	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1185652000380	active site
1185652000381	dimer interface [polypeptide binding]; other site
1185652000382	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1185652000383	dimer interface [polypeptide binding]; other site
1185652000384	active site
1185652000385	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
1185652000386	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1185652000387	acyl-activating enzyme (AAE) consensus motif; other site
1185652000388	putative AMP binding site [chemical binding]; other site
1185652000389	putative active site [active]
1185652000390	putative CoA binding site [chemical binding]; other site
1185652000391	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1185652000392	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1185652000393	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1185652000394	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1185652000395	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1185652000396	Ligand Binding Site [chemical binding]; other site
1185652000397	GAF domain; Region: GAF_3; pfam13492
1185652000398	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652000399	dimer interface [polypeptide binding]; other site
1185652000400	phosphorylation site [posttranslational modification]
1185652000401	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652000402	ATP binding site [chemical binding]; other site
1185652000403	Mg2+ binding site [ion binding]; other site
1185652000404	G-X-G motif; other site
1185652000405	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1185652000406	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1185652000407	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1185652000408	putative acyl-acceptor binding pocket; other site
1185652000409	Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589
1185652000410	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1185652000411	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1185652000412	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1185652000413	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652000414	dimer interface [polypeptide binding]; other site
1185652000415	phosphorylation site [posttranslational modification]
1185652000416	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652000417	ATP binding site [chemical binding]; other site
1185652000418	Mg2+ binding site [ion binding]; other site
1185652000419	G-X-G motif; other site
1185652000420	PBP superfamily domain; Region: PBP_like_2; pfam12849
1185652000421	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
1185652000422	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1185652000423	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652000424	dimer interface [polypeptide binding]; other site
1185652000425	conserved gate region; other site
1185652000426	putative PBP binding loops; other site
1185652000427	ABC-ATPase subunit interface; other site
1185652000428	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
1185652000429	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1185652000430	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652000431	dimer interface [polypeptide binding]; other site
1185652000432	conserved gate region; other site
1185652000433	putative PBP binding loops; other site
1185652000434	ABC-ATPase subunit interface; other site
1185652000435	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
1185652000436	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1185652000437	Walker A/P-loop; other site
1185652000438	ATP binding site [chemical binding]; other site
1185652000439	Q-loop/lid; other site
1185652000440	ABC transporter signature motif; other site
1185652000441	Walker B; other site
1185652000442	D-loop; other site
1185652000443	H-loop/switch region; other site
1185652000444	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1185652000445	PhoU domain; Region: PhoU; pfam01895
1185652000446	PhoU domain; Region: PhoU; pfam01895
1185652000447	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
1185652000448	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652000449	active site
1185652000450	phosphorylation site [posttranslational modification]
1185652000451	intermolecular recognition site; other site
1185652000452	dimerization interface [polypeptide binding]; other site
1185652000453	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652000454	DNA binding site [nucleotide binding]
1185652000455	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352
1185652000456	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
1185652000457	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1185652000458	inhibitor-cofactor binding pocket; inhibition site
1185652000459	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652000460	catalytic residue [active]
1185652000461	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1185652000462	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1185652000463	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1185652000464	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1185652000465	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1185652000466	dimerization interface [polypeptide binding]; other site
1185652000467	domain crossover interface; other site
1185652000468	redox-dependent activation switch; other site
1185652000469	Uncharacterized protein affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism]; Region: ApaG; COG2967
1185652000470	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1185652000471	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
1185652000472	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1185652000473	homodimer interface [polypeptide binding]; other site
1185652000474	substrate-cofactor binding pocket; other site
1185652000475	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652000476	catalytic residue [active]
1185652000477	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
1185652000478	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1185652000479	trimer interface [polypeptide binding]; other site
1185652000480	active site
1185652000481	Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717
1185652000482	trimer interface [polypeptide binding]; other site
1185652000483	active site
1185652000484	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1185652000485	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1185652000486	tellurite resistance protein terB; Region: terB; cd07176
1185652000487	putative metal binding site [ion binding]; other site
1185652000488	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
1185652000489	Predicted transcriptional regulator [Transcription]; Region: COG2932
1185652000490	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1185652000491	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1185652000492	Catalytic site [active]
1185652000493	Predicted transcriptional regulators [Transcription]; Region: COG1733
1185652000494	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1185652000495	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900
1185652000496	putative hydrophobic ligand binding site [chemical binding]; other site
1185652000497	LysE type translocator; Region: LysE; cl00565
1185652000498	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
1185652000499	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1185652000500	substrate binding site [chemical binding]; other site
1185652000501	oxyanion hole (OAH) forming residues; other site
1185652000502	trimer interface [polypeptide binding]; other site
1185652000503	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1185652000504	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1185652000505	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1185652000506	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
1185652000507	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1185652000508	dimer interface [polypeptide binding]; other site
1185652000509	active site
1185652000510	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1185652000511	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1185652000512	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
1185652000513	FAD binding site [chemical binding]; other site
1185652000514	substrate binding site [chemical binding]; other site
1185652000515	catalytic residues [active]
1185652000516	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1185652000517	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1185652000518	Sel1-like repeats; Region: SEL1; smart00671
1185652000519	Sel1-like repeats; Region: SEL1; smart00671
1185652000520	Sel1-like repeats; Region: SEL1; smart00671
1185652000521	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1185652000522	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1185652000523	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1185652000524	conserved hypothetical protein; Region: alph_Pro_TM; TIGR02186
1185652000525	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652000526	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652000527	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
1185652000528	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1185652000529	putative active site [active]
1185652000530	putative metal binding site [ion binding]; other site
1185652000531	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
1185652000532	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1185652000533	ATP binding site [chemical binding]; other site
1185652000534	putative Mg++ binding site [ion binding]; other site
1185652000535	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1185652000536	nucleotide binding region [chemical binding]; other site
1185652000537	ATP-binding site [chemical binding]; other site
1185652000538	DEAD/H associated; Region: DEAD_assoc; pfam08494
1185652000539	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1185652000540	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1185652000541	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
1185652000542	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652000543	TPR motif; other site
1185652000544	binding surface
1185652000545	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652000546	S-adenosylmethionine binding site [chemical binding]; other site
1185652000547	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1185652000548	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1185652000549	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
1185652000550	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1185652000551	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1185652000552	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1185652000553	quinone interaction residues [chemical binding]; other site
1185652000554	active site
1185652000555	catalytic residues [active]
1185652000556	FMN binding site [chemical binding]; other site
1185652000557	substrate binding site [chemical binding]; other site
1185652000558	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
1185652000559	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652000560	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652000561	active site
1185652000562	phosphorylation site [posttranslational modification]
1185652000563	intermolecular recognition site; other site
1185652000564	dimerization interface [polypeptide binding]; other site
1185652000565	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652000566	DNA binding residues [nucleotide binding]
1185652000567	dimerization interface [polypeptide binding]; other site
1185652000568	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
1185652000569	Na binding site [ion binding]; other site
1185652000570	PAS fold; Region: PAS_7; pfam12860
1185652000571	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652000572	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652000573	dimer interface [polypeptide binding]; other site
1185652000574	phosphorylation site [posttranslational modification]
1185652000575	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652000576	ATP binding site [chemical binding]; other site
1185652000577	Mg2+ binding site [ion binding]; other site
1185652000578	G-X-G motif; other site
1185652000579	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1185652000580	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652000581	active site
1185652000582	phosphorylation site [posttranslational modification]
1185652000583	intermolecular recognition site; other site
1185652000584	dimerization interface [polypeptide binding]; other site
1185652000585	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
1185652000586	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1185652000587	aspartate aminotransferase; Provisional; Region: PRK06108
1185652000588	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652000589	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652000590	homodimer interface [polypeptide binding]; other site
1185652000591	catalytic residue [active]
1185652000592	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1185652000593	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1185652000594	NAD binding site [chemical binding]; other site
1185652000595	homodimer interface [polypeptide binding]; other site
1185652000596	active site
1185652000597	substrate binding site [chemical binding]; other site
1185652000598	Chorismate mutase type II; Region: CM_2; cl00693
1185652000599	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1185652000600	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1185652000601	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1185652000602	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1185652000603	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1185652000604	metal binding site [ion binding]; metal-binding site
1185652000605	putative dimer interface [polypeptide binding]; other site
1185652000606	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1185652000607	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652000608	dimer interface [polypeptide binding]; other site
1185652000609	conserved gate region; other site
1185652000610	putative PBP binding loops; other site
1185652000611	ABC-ATPase subunit interface; other site
1185652000612	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1185652000613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652000614	dimer interface [polypeptide binding]; other site
1185652000615	conserved gate region; other site
1185652000616	putative PBP binding loops; other site
1185652000617	ABC-ATPase subunit interface; other site
1185652000618	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
1185652000619	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652000620	Walker A/P-loop; other site
1185652000621	ATP binding site [chemical binding]; other site
1185652000622	Q-loop/lid; other site
1185652000623	ABC transporter signature motif; other site
1185652000624	Walker B; other site
1185652000625	D-loop; other site
1185652000626	H-loop/switch region; other site
1185652000627	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
1185652000628	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652000629	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1185652000630	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1185652000631	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652000632	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652000633	homodimer interface [polypeptide binding]; other site
1185652000634	catalytic residue [active]
1185652000635	hypothetical protein; Provisional; Region: PRK07524
1185652000636	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1185652000637	PYR/PP interface [polypeptide binding]; other site
1185652000638	dimer interface [polypeptide binding]; other site
1185652000639	TPP binding site [chemical binding]; other site
1185652000640	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1185652000641	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1185652000642	TPP-binding site [chemical binding]; other site
1185652000643	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1185652000644	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
1185652000645	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1185652000646	Protein export membrane protein; Region: SecD_SecF; pfam02355
1185652000647	KpsF/GutQ family protein; Region: kpsF; TIGR00393
1185652000648	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1185652000649	putative active site [active]
1185652000650	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1185652000651	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
1185652000652	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
1185652000653	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1185652000654	Sulfatase; Region: Sulfatase; cl17466
1185652000655	3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939
1185652000656	putative NAD(P) binding site [chemical binding]; other site
1185652000657	homotetramer interface [polypeptide binding]; other site
1185652000658	active site
1185652000659	homodimer interface [polypeptide binding]; other site
1185652000660	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1185652000661	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1185652000662	substrate-cofactor binding pocket; other site
1185652000663	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652000664	catalytic residue [active]
1185652000665	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1185652000666	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1185652000667	active site
1185652000668	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1185652000669	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1185652000670	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1185652000671	Enoylreductase; Region: PKS_ER; smart00829
1185652000672	NAD(P) binding site [chemical binding]; other site
1185652000673	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1185652000674	KR domain; Region: KR; pfam08659
1185652000675	putative NADP binding site [chemical binding]; other site
1185652000676	active site
1185652000677	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1185652000678	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
1185652000679	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1185652000680	SLBB domain; Region: SLBB; pfam10531
1185652000681	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1185652000682	Isochorismatase family; Region: Isochorismatase; pfam00857
1185652000683	catalytic triad [active]
1185652000684	metal binding site [ion binding]; metal-binding site
1185652000685	conserved cis-peptide bond; other site
1185652000686	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
1185652000687	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
1185652000688	active site
1185652000689	Transglycosylase; Region: Transgly; pfam00912
1185652000690	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1185652000691	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1185652000692	BA14K-like protein; Region: BA14K; pfam07886
1185652000693	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338
1185652000694	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1185652000695	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1185652000696	catalytic residues [active]
1185652000697	catalytic nucleophile [active]
1185652000698	Presynaptic Site I dimer interface [polypeptide binding]; other site
1185652000699	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1185652000700	Synaptic Flat tetramer interface [polypeptide binding]; other site
1185652000701	Synaptic Site I dimer interface [polypeptide binding]; other site
1185652000702	DNA binding site [nucleotide binding]
1185652000703	Recombinase; Region: Recombinase; pfam07508
1185652000704	Helix-turn-helix domain; Region: HTH_36; pfam13730
1185652000705	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1185652000706	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1185652000707	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1185652000708	ATP binding site [chemical binding]; other site
1185652000709	putative Mg++ binding site [ion binding]; other site
1185652000710	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
1185652000711	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1185652000712	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1185652000713	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1185652000714	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1185652000715	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1185652000716	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652000717	S-adenosylmethionine binding site [chemical binding]; other site
1185652000718	INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184
1185652000719	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1185652000720	Int/Topo IB signature motif; other site
1185652000721	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1185652000722	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1185652000723	hinge; other site
1185652000724	active site
1185652000725	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
1185652000726	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1185652000727	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1185652000728	NAD binding site [chemical binding]; other site
1185652000729	dimerization interface [polypeptide binding]; other site
1185652000730	product binding site; other site
1185652000731	substrate binding site [chemical binding]; other site
1185652000732	zinc binding site [ion binding]; other site
1185652000733	catalytic residues [active]
1185652000734	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5328
1185652000735	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1185652000736	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1185652000737	active site
1185652000738	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1185652000739	rRNA binding site [nucleotide binding]; other site
1185652000740	predicted 30S ribosome binding site; other site
1185652000741	Maf-like protein; Region: Maf; pfam02545
1185652000742	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1185652000743	active site
1185652000744	dimer interface [polypeptide binding]; other site
1185652000745	zinc-binding protein; Provisional; Region: PRK01343
1185652000746	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1185652000747	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1185652000748	tetramer interface [polypeptide binding]; other site
1185652000749	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652000750	catalytic residue [active]
1185652000751	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
1185652000752	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1185652000753	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652000754	Coenzyme A binding pocket [chemical binding]; other site
1185652000755	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1185652000756	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
1185652000757	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652000758	Coenzyme A binding pocket [chemical binding]; other site
1185652000759	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652000760	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652000761	putative DNA binding site [nucleotide binding]; other site
1185652000762	putative Zn2+ binding site [ion binding]; other site
1185652000763	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652000764	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
1185652000765	tartrate dehydrogenase; Region: TTC; TIGR02089
1185652000766	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1185652000767	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652000768	DNA-binding site [nucleotide binding]; DNA binding site
1185652000769	FCD domain; Region: FCD; pfam07729
1185652000770	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
1185652000771	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1185652000772	inhibitor-cofactor binding pocket; inhibition site
1185652000773	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652000774	catalytic residue [active]
1185652000775	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1185652000776	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1185652000777	active site
1185652000778	ATP binding site [chemical binding]; other site
1185652000779	substrate binding site [chemical binding]; other site
1185652000780	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1185652000781	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
1185652000782	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1185652000783	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652000784	motif II; other site
1185652000785	Phosphotransferase enzyme family; Region: APH; pfam01636
1185652000786	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1185652000787	active site
1185652000788	ATP binding site [chemical binding]; other site
1185652000789	substrate binding site [chemical binding]; other site
1185652000790	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
1185652000791	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1185652000792	inhibitor-cofactor binding pocket; inhibition site
1185652000793	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652000794	catalytic residue [active]
1185652000795	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652000796	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652000797	putative DNA binding site [nucleotide binding]; other site
1185652000798	putative Zn2+ binding site [ion binding]; other site
1185652000799	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652000800	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1185652000801	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652000802	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1185652000803	phosphate binding site [ion binding]; other site
1185652000804	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
1185652000805	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1185652000806	Protein of unknown function, DUF1537; Region: DUF1537; cl01345
1185652000807	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1185652000808	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652000809	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652000810	dimerization interface [polypeptide binding]; other site
1185652000811	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1185652000812	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652000813	DNA-binding site [nucleotide binding]; DNA binding site
1185652000814	FCD domain; Region: FCD; pfam07729
1185652000815	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1185652000816	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652000817	Walker A/P-loop; other site
1185652000818	ATP binding site [chemical binding]; other site
1185652000819	Q-loop/lid; other site
1185652000820	ABC transporter signature motif; other site
1185652000821	Walker B; other site
1185652000822	D-loop; other site
1185652000823	H-loop/switch region; other site
1185652000824	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1185652000825	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652000826	Walker A/P-loop; other site
1185652000827	ATP binding site [chemical binding]; other site
1185652000828	Q-loop/lid; other site
1185652000829	ABC transporter signature motif; other site
1185652000830	Walker B; other site
1185652000831	D-loop; other site
1185652000832	H-loop/switch region; other site
1185652000833	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652000834	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1185652000835	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
1185652000836	peptide binding site [polypeptide binding]; other site
1185652000837	dimer interface [polypeptide binding]; other site
1185652000838	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1185652000839	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652000840	dimer interface [polypeptide binding]; other site
1185652000841	conserved gate region; other site
1185652000842	putative PBP binding loops; other site
1185652000843	ABC-ATPase subunit interface; other site
1185652000844	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1185652000845	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1185652000846	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652000847	dimer interface [polypeptide binding]; other site
1185652000848	conserved gate region; other site
1185652000849	putative PBP binding loops; other site
1185652000850	ABC-ATPase subunit interface; other site
1185652000851	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1185652000852	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652000853	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652000854	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1185652000855	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652000856	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652000857	putative DNA binding site [nucleotide binding]; other site
1185652000858	putative Zn2+ binding site [ion binding]; other site
1185652000859	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652000860	succinic semialdehyde dehydrogenase; Region: PLN02278
1185652000861	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1185652000862	tetramerization interface [polypeptide binding]; other site
1185652000863	NAD(P) binding site [chemical binding]; other site
1185652000864	catalytic residues [active]
1185652000865	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
1185652000866	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1185652000867	putative trimer interface [polypeptide binding]; other site
1185652000868	putative CoA binding site [chemical binding]; other site
1185652000869	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1185652000870	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652000871	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652000872	putative DNA binding site [nucleotide binding]; other site
1185652000873	putative Zn2+ binding site [ion binding]; other site
1185652000874	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652000875	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652000876	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652000877	putative DNA binding site [nucleotide binding]; other site
1185652000878	putative Zn2+ binding site [ion binding]; other site
1185652000879	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652000880	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1185652000881	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1185652000882	active site
1185652000883	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1185652000884	dimer interface [polypeptide binding]; other site
1185652000885	substrate binding site [chemical binding]; other site
1185652000886	catalytic residues [active]
1185652000887	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1185652000888	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652000889	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1185652000890	homotrimer interaction site [polypeptide binding]; other site
1185652000891	putative active site [active]
1185652000892	Helix-turn-helix domain; Region: HTH_20; pfam12840
1185652000893	putative DNA binding site [nucleotide binding]; other site
1185652000894	putative Zn2+ binding site [ion binding]; other site
1185652000895	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1185652000896	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1185652000897	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1185652000898	Int/Topo IB signature motif; other site
1185652000899	Winged helix-turn helix; Region: HTH_29; pfam13551
1185652000900	Helix-turn-helix domain; Region: HTH_28; pfam13518
1185652000901	Homeodomain-like domain; Region: HTH_32; pfam13565
1185652000902	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1185652000903	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
1185652000904	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1185652000905	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1185652000906	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652000907	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1185652000908	NAD(P) binding site [chemical binding]; other site
1185652000909	active site
1185652000910	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1185652000911	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652000912	non-specific DNA binding site [nucleotide binding]; other site
1185652000913	salt bridge; other site
1185652000914	sequence-specific DNA binding site [nucleotide binding]; other site
1185652000915	Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
1185652000916	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
1185652000917	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652000918	binding surface
1185652000919	TPR motif; other site
1185652000920	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1185652000921	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1185652000922	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1185652000923	UDP-galactopyranose mutase; Region: GLF; pfam03275
1185652000924	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1185652000925	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1185652000926	conserved cys residue [active]
1185652000927	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652000928	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652000929	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
1185652000930	putative deacylase active site [active]
1185652000931	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952
1185652000932	L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629
1185652000933	short chain dehydrogenase; Validated; Region: PRK08324
1185652000934	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
1185652000935	active site
1185652000936	Zn2+ binding site [ion binding]; other site
1185652000937	intersubunit interface [polypeptide binding]; other site
1185652000938	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652000939	NAD(P) binding site [chemical binding]; other site
1185652000940	active site
1185652000941	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1185652000942	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1185652000943	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1185652000944	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
1185652000945	rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637
1185652000946	ligand binding site [chemical binding]; other site
1185652000947	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1185652000948	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652000949	Walker A/P-loop; other site
1185652000950	ATP binding site [chemical binding]; other site
1185652000951	Q-loop/lid; other site
1185652000952	ABC transporter signature motif; other site
1185652000953	Walker B; other site
1185652000954	D-loop; other site
1185652000955	H-loop/switch region; other site
1185652000956	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652000957	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652000958	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652000959	TM-ABC transporter signature motif; other site
1185652000960	Uncharacterized conserved protein [Function unknown]; Region: COG3254
1185652000961	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1185652000962	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1185652000963	nucleotide binding site [chemical binding]; other site
1185652000964	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
1185652000965	heme-binding site [chemical binding]; other site
1185652000966	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1185652000967	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1185652000968	dimer interface [polypeptide binding]; other site
1185652000969	putative CheW interface [polypeptide binding]; other site
1185652000970	STAS domain; Region: STAS_2; pfam13466
1185652000971	Response regulator receiver domain; Region: Response_reg; pfam00072
1185652000972	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652000973	active site
1185652000974	phosphorylation site [posttranslational modification]
1185652000975	intermolecular recognition site; other site
1185652000976	dimerization interface [polypeptide binding]; other site
1185652000977	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1185652000978	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1185652000979	putative binding surface; other site
1185652000980	active site
1185652000981	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1185652000982	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652000983	ATP binding site [chemical binding]; other site
1185652000984	Mg2+ binding site [ion binding]; other site
1185652000985	G-X-G motif; other site
1185652000986	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1185652000987	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1185652000988	putative CheA interaction surface; other site
1185652000989	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1185652000990	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
1185652000991	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1185652000992	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1185652000993	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652000994	active site
1185652000995	phosphorylation site [posttranslational modification]
1185652000996	intermolecular recognition site; other site
1185652000997	dimerization interface [polypeptide binding]; other site
1185652000998	CheB methylesterase; Region: CheB_methylest; pfam01339
1185652000999	Response regulator receiver domain; Region: Response_reg; pfam00072
1185652001000	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652001001	active site
1185652001002	phosphorylation site [posttranslational modification]
1185652001003	intermolecular recognition site; other site
1185652001004	dimerization interface [polypeptide binding]; other site
1185652001005	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13497
1185652001006	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
1185652001007	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
1185652001008	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1185652001009	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652001010	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652001011	DNA binding residues [nucleotide binding]
1185652001012	dimerization interface [polypeptide binding]; other site
1185652001013	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652001014	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652001015	DNA binding residues [nucleotide binding]
1185652001016	dimerization interface [polypeptide binding]; other site
1185652001017	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
1185652001018	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1185652001019	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
1185652001020	MgtE intracellular N domain; Region: MgtE_N; cl15244
1185652001021	FliG C-terminal domain; Region: FliG_C; pfam01706
1185652001022	flagellar motor switch protein FliN; Region: fliN; TIGR02480
1185652001023	Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868
1185652001024	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1185652001025	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1185652001026	flagellar motor protein MotA; Validated; Region: PRK09110
1185652001027	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
1185652001028	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
1185652001029	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
1185652001030	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1185652001031	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
1185652001032	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
1185652001033	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1185652001034	Walker A motif; other site
1185652001035	ATP binding site [chemical binding]; other site
1185652001036	Walker B motif; other site
1185652001037	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
1185652001038	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1185652001039	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
1185652001040	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1185652001041	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1185652001042	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790
1185652001043	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
1185652001044	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1185652001045	Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261
1185652001046	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1185652001047	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
1185652001048	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
1185652001049	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
1185652001050	Uncharacterized conserved protein [Function unknown]; Region: COG3334
1185652001051	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
1185652001052	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
1185652001053	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
1185652001054	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
1185652001055	flagellin; Reviewed; Region: PRK12687
1185652001056	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1185652001057	flagellin; Reviewed; Region: PRK12687
1185652001058	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1185652001059	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1185652001060	flagellin; Reviewed; Region: PRK12687
1185652001061	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1185652001062	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1185652001063	flagellin; Reviewed; Region: PRK12687
1185652001064	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1185652001065	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1185652001066	flagellar motor protein MotB; Validated; Region: motB; PRK05996
1185652001067	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1185652001068	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1185652001069	ligand binding site [chemical binding]; other site
1185652001070	chemotaxis protein; Reviewed; Region: PRK12798
1185652001071	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1185652001072	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1185652001073	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1185652001074	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1185652001075	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652001076	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652001077	DNA binding site [nucleotide binding]
1185652001078	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
1185652001079	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1185652001080	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
1185652001081	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1185652001082	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
1185652001083	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
1185652001084	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1185652001085	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1185652001086	Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442
1185652001087	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793
1185652001088	Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443
1185652001089	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
1185652001090	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1185652001091	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
1185652001092	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
1185652001093	FHIPEP family; Region: FHIPEP; pfam00771
1185652001094	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
1185652001095	Rod binding protein; Region: Rod-binding; pfam10135
1185652001096	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1185652001097	active site
1185652001098	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
1185652001099	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1185652001100	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1185652001101	homodimer interface [polypeptide binding]; other site
1185652001102	NADP binding site [chemical binding]; other site
1185652001103	substrate binding site [chemical binding]; other site
1185652001104	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652001105	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652001106	DNA binding site [nucleotide binding]
1185652001107	domain linker motif; other site
1185652001108	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
1185652001109	ligand binding site [chemical binding]; other site
1185652001110	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652001111	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652001112	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652001113	conserved gate region; other site
1185652001114	putative PBP binding loops; other site
1185652001115	ABC-ATPase subunit interface; other site
1185652001116	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652001117	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652001118	dimer interface [polypeptide binding]; other site
1185652001119	conserved gate region; other site
1185652001120	putative PBP binding loops; other site
1185652001121	ABC-ATPase subunit interface; other site
1185652001122	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
1185652001123	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1185652001124	active site
1185652001125	catalytic site [active]
1185652001126	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1185652001127	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652001128	Walker A/P-loop; other site
1185652001129	ATP binding site [chemical binding]; other site
1185652001130	Q-loop/lid; other site
1185652001131	ABC transporter signature motif; other site
1185652001132	Walker B; other site
1185652001133	D-loop; other site
1185652001134	H-loop/switch region; other site
1185652001135	TOBE domain; Region: TOBE; pfam03459
1185652001136	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
1185652001137	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1185652001138	active site
1185652001139	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1185652001140	phosphogluconate dehydratase; Validated; Region: PRK09054
1185652001141	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1185652001142	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1185652001143	putative active site [active]
1185652001144	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1185652001145	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1185652001146	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1185652001147	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1185652001148	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652001149	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1185652001150	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1185652001151	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1185652001152	Predicted flavoproteins [General function prediction only]; Region: COG2081
1185652001153	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1185652001154	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1185652001155	dimerization interface [polypeptide binding]; other site
1185652001156	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1185652001157	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1185652001158	dimer interface [polypeptide binding]; other site
1185652001159	putative CheW interface [polypeptide binding]; other site
1185652001160	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652001161	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652001162	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652001163	isocitrate lyase; Provisional; Region: PRK15063
1185652001164	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1185652001165	tetramer interface [polypeptide binding]; other site
1185652001166	active site
1185652001167	Mg2+/Mn2+ binding site [ion binding]; other site
1185652001168	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1185652001169	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652001170	non-specific DNA binding site [nucleotide binding]; other site
1185652001171	salt bridge; other site
1185652001172	sequence-specific DNA binding site [nucleotide binding]; other site
1185652001173	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1185652001174	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1185652001175	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1185652001176	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
1185652001177	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1185652001178	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1185652001179	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1185652001180	Walker A/P-loop; other site
1185652001181	ATP binding site [chemical binding]; other site
1185652001182	Q-loop/lid; other site
1185652001183	ABC transporter signature motif; other site
1185652001184	Walker B; other site
1185652001185	D-loop; other site
1185652001186	H-loop/switch region; other site
1185652001187	TOBE domain; Region: TOBE_2; pfam08402
1185652001188	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652001189	dimer interface [polypeptide binding]; other site
1185652001190	conserved gate region; other site
1185652001191	putative PBP binding loops; other site
1185652001192	ABC-ATPase subunit interface; other site
1185652001193	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1185652001194	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652001195	dimer interface [polypeptide binding]; other site
1185652001196	conserved gate region; other site
1185652001197	putative PBP binding loops; other site
1185652001198	ABC-ATPase subunit interface; other site
1185652001199	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
1185652001200	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1185652001201	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
1185652001202	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
1185652001203	acyl-activating enzyme (AAE) consensus motif; other site
1185652001204	putative AMP binding site [chemical binding]; other site
1185652001205	putative active site [active]
1185652001206	putative CoA binding site [chemical binding]; other site
1185652001207	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1185652001208	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1185652001209	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652001210	putative PBP binding loops; other site
1185652001211	dimer interface [polypeptide binding]; other site
1185652001212	ABC-ATPase subunit interface; other site
1185652001213	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652001214	dimer interface [polypeptide binding]; other site
1185652001215	conserved gate region; other site
1185652001216	putative PBP binding loops; other site
1185652001217	ABC-ATPase subunit interface; other site
1185652001218	PAS domain S-box; Region: sensory_box; TIGR00229
1185652001219	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652001220	putative active site [active]
1185652001221	heme pocket [chemical binding]; other site
1185652001222	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652001223	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652001224	dimer interface [polypeptide binding]; other site
1185652001225	phosphorylation site [posttranslational modification]
1185652001226	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652001227	ATP binding site [chemical binding]; other site
1185652001228	Mg2+ binding site [ion binding]; other site
1185652001229	G-X-G motif; other site
1185652001230	Phasin protein; Region: Phasin_2; cl11491
1185652001231	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1185652001232	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1185652001233	tetrameric interface [polypeptide binding]; other site
1185652001234	NAD binding site [chemical binding]; other site
1185652001235	catalytic residues [active]
1185652001236	Predicted membrane protein [Function unknown]; Region: COG4269
1185652001237	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1185652001238	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1185652001239	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1185652001240	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1185652001241	iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920
1185652001242	Rrf2 family protein; Region: rrf2_super; TIGR00738
1185652001243	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1185652001244	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1185652001245	peptide binding site [polypeptide binding]; other site
1185652001246	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1185652001247	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652001248	dimer interface [polypeptide binding]; other site
1185652001249	conserved gate region; other site
1185652001250	putative PBP binding loops; other site
1185652001251	ABC-ATPase subunit interface; other site
1185652001252	dipeptide transporter; Provisional; Region: PRK10913
1185652001253	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652001254	dimer interface [polypeptide binding]; other site
1185652001255	conserved gate region; other site
1185652001256	putative PBP binding loops; other site
1185652001257	ABC-ATPase subunit interface; other site
1185652001258	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1185652001259	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652001260	Walker A/P-loop; other site
1185652001261	ATP binding site [chemical binding]; other site
1185652001262	Q-loop/lid; other site
1185652001263	ABC transporter signature motif; other site
1185652001264	Walker B; other site
1185652001265	D-loop; other site
1185652001266	H-loop/switch region; other site
1185652001267	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652001268	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652001269	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1185652001270	Walker A/P-loop; other site
1185652001271	ATP binding site [chemical binding]; other site
1185652001272	Q-loop/lid; other site
1185652001273	ABC transporter signature motif; other site
1185652001274	Walker B; other site
1185652001275	D-loop; other site
1185652001276	H-loop/switch region; other site
1185652001277	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652001278	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1185652001279	homotrimer interaction site [polypeptide binding]; other site
1185652001280	putative active site [active]
1185652001281	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1185652001282	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1185652001283	two-component response regulator; Provisional; Region: PRK09191
1185652001284	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1185652001285	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652001286	active site
1185652001287	phosphorylation site [posttranslational modification]
1185652001288	intermolecular recognition site; other site
1185652001289	dimerization interface [polypeptide binding]; other site
1185652001290	Small integral membrane protein [Function unknown]; Region: COG5487; cl17674
1185652001291	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652001292	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1185652001293	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1185652001294	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1185652001295	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
1185652001296	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1185652001297	MgtC family; Region: MgtC; pfam02308
1185652001298	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
1185652001299	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1185652001300	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1185652001301	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
1185652001302	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
1185652001303	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652001304	cyclase homology domain; Region: CHD; cd07302
1185652001305	nucleotidyl binding site; other site
1185652001306	metal binding site [ion binding]; metal-binding site
1185652001307	dimer interface [polypeptide binding]; other site
1185652001308	Predicted integral membrane protein [Function unknown]; Region: COG5616
1185652001309	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652001310	TPR motif; other site
1185652001311	binding surface
1185652001312	TPR repeat; Region: TPR_11; pfam13414
1185652001313	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652001314	binding surface
1185652001315	TPR motif; other site
1185652001316	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1185652001317	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1185652001318	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652001319	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
1185652001320	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
1185652001321	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
1185652001322	short chain dehydrogenase; Provisional; Region: PRK07109
1185652001323	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652001324	NAD(P) binding site [chemical binding]; other site
1185652001325	active site
1185652001326	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
1185652001327	CHRD domain; Region: CHRD; pfam07452
1185652001328	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
1185652001329	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652001330	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1185652001331	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1185652001332	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1185652001333	Int/Topo IB signature motif; other site
1185652001334	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
1185652001335	active site
1185652001336	metal binding site [ion binding]; metal-binding site
1185652001337	interdomain interaction site; other site
1185652001338	AAA domain; Region: AAA_25; pfam13481
1185652001339	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1185652001340	Walker A motif; other site
1185652001341	ATP binding site [chemical binding]; other site
1185652001342	Walker B motif; other site
1185652001343	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1185652001344	putative catalytic site [active]
1185652001345	putative metal binding site [ion binding]; other site
1185652001346	putative phosphate binding site [ion binding]; other site
1185652001347	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1185652001348	Excalibur calcium-binding domain; Region: Excalibur; cl05460
1185652001349	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1185652001350	ATP binding site [chemical binding]; other site
1185652001351	putative Mg++ binding site [ion binding]; other site
1185652001352	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1185652001353	nucleotide binding region [chemical binding]; other site
1185652001354	ATP-binding site [chemical binding]; other site
1185652001355	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1185652001356	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1185652001357	ATP binding site [chemical binding]; other site
1185652001358	putative Mg++ binding site [ion binding]; other site
1185652001359	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1185652001360	nucleotide binding region [chemical binding]; other site
1185652001361	ATP-binding site [chemical binding]; other site
1185652001362	AAA ATPase domain; Region: AAA_16; pfam13191
1185652001363	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1185652001364	ATP binding site [chemical binding]; other site
1185652001365	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1185652001366	ATP-binding site [chemical binding]; other site
1185652001367	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1185652001368	Ligand Binding Site [chemical binding]; other site
1185652001369	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
1185652001370	active site
1185652001371	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
1185652001372	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1185652001373	FeS/SAM binding site; other site
1185652001374	DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172
1185652001375	DGQHR domain; Region: DGQHR; TIGR03187
1185652001376	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1185652001377	DNA-sulfur modification-associated; Region: DndB; cl17621
1185652001378	DGQHR domain; Region: DGQHR; TIGR03187
1185652001379	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1185652001380	Transposase domain (DUF772); Region: DUF772; pfam05598
1185652001381	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1185652001382	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1185652001383	MULE transposase domain; Region: MULE; pfam10551
1185652001384	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1185652001385	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1185652001386	Transposase; Region: HTH_Tnp_1; pfam01527
1185652001387	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652001388	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1185652001389	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1185652001390	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652001391	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1185652001392	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652001393	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1185652001394	cyclase homology domain; Region: CHD; cd07302
1185652001395	dimer interface [polypeptide binding]; other site
1185652001396	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652001397	nucleotidyl binding site; other site
1185652001398	metal binding site [ion binding]; metal-binding site
1185652001399	Predicted integral membrane protein [Function unknown]; Region: COG5616
1185652001400	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652001401	binding surface
1185652001402	TPR motif; other site
1185652001403	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652001404	TPR motif; other site
1185652001405	binding surface
1185652001406	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
1185652001407	homotrimer interaction site [polypeptide binding]; other site
1185652001408	Cupin domain; Region: Cupin_2; cl17218
1185652001409	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652001410	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652001411	DNA binding site [nucleotide binding]
1185652001412	Predicted integral membrane protein [Function unknown]; Region: COG5616
1185652001413	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652001414	TPR motif; other site
1185652001415	TPR repeat; Region: TPR_11; pfam13414
1185652001416	binding surface
1185652001417	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
1185652001418	Predicted transcriptional regulator [Transcription]; Region: COG4190
1185652001419	MarR family; Region: MarR_2; pfam12802
1185652001420	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
1185652001421	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1185652001422	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1185652001423	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
1185652001424	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652001425	S-adenosylmethionine binding site [chemical binding]; other site
1185652001426	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652001427	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
1185652001428	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652001429	putative substrate translocation pore; other site
1185652001430	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1185652001431	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1185652001432	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1185652001433	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1185652001434	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1185652001435	active site
1185652001436	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5331
1185652001437	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1185652001438	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
1185652001439	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652001440	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1185652001441	dimerization interface [polypeptide binding]; other site
1185652001442	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652001443	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652001444	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652001445	dimerization interface [polypeptide binding]; other site
1185652001446	Uncharacterized conserved protein [Function unknown]; Region: COG5403
1185652001447	Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572
1185652001448	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1185652001449	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1185652001450	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1185652001451	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
1185652001452	nudix motif; other site
1185652001453	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1185652001454	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652001455	DNA-binding site [nucleotide binding]; DNA binding site
1185652001456	FCD domain; Region: FCD; pfam07729
1185652001457	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4949
1185652001458	transcriptional activator TtdR; Provisional; Region: PRK09801
1185652001459	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1185652001460	putative effector binding pocket; other site
1185652001461	dimerization interface [polypeptide binding]; other site
1185652001462	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
1185652001463	FAD binding domain; Region: FAD_binding_4; pfam01565
1185652001464	FAD binding domain; Region: FAD_binding_4; pfam01565
1185652001465	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
1185652001466	Predicted membrane protein [Function unknown]; Region: COG3671
1185652001467	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
1185652001468	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1185652001469	Cysteine-rich domain; Region: CCG; pfam02754
1185652001470	Cysteine-rich domain; Region: CCG; pfam02754
1185652001471	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1185652001472	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1185652001473	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1185652001474	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1185652001475	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1185652001476	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544
1185652001477	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
1185652001478	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1185652001479	dimer interface [polypeptide binding]; other site
1185652001480	motif 1; other site
1185652001481	motif 2; other site
1185652001482	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1185652001483	active site
1185652001484	motif 3; other site
1185652001485	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1185652001486	anticodon binding site; other site
1185652001487	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
1185652001488	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1185652001489	dimer interface [polypeptide binding]; other site
1185652001490	motif 1; other site
1185652001491	active site
1185652001492	motif 2; other site
1185652001493	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1185652001494	motif 3; other site
1185652001495	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1185652001496	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1185652001497	C-terminal domain interface [polypeptide binding]; other site
1185652001498	GSH binding site (G-site) [chemical binding]; other site
1185652001499	dimer interface [polypeptide binding]; other site
1185652001500	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
1185652001501	dimer interface [polypeptide binding]; other site
1185652001502	N-terminal domain interface [polypeptide binding]; other site
1185652001503	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1185652001504	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1185652001505	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652001506	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1185652001507	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1185652001508	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1185652001509	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652001510	PAS domain; Region: PAS_9; pfam13426
1185652001511	putative active site [active]
1185652001512	heme pocket [chemical binding]; other site
1185652001513	PAS fold; Region: PAS_7; pfam12860
1185652001514	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652001515	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652001516	metal binding site [ion binding]; metal-binding site
1185652001517	active site
1185652001518	I-site; other site
1185652001519	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1185652001520	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1185652001521	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1185652001522	ring oligomerisation interface [polypeptide binding]; other site
1185652001523	ATP/Mg binding site [chemical binding]; other site
1185652001524	stacking interactions; other site
1185652001525	hinge regions; other site
1185652001526	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1185652001527	oligomerisation interface [polypeptide binding]; other site
1185652001528	mobile loop; other site
1185652001529	roof hairpin; other site
1185652001530	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
1185652001531	active site residue [active]
1185652001532	Uncharacterized conserved protein [Function unknown]; Region: COG4275
1185652001533	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1185652001534	Chromate transporter; Region: Chromate_transp; pfam02417
1185652001535	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1185652001536	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
1185652001537	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1185652001538	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1185652001539	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1185652001540	active site
1185652001541	Riboflavin kinase; Region: Flavokinase; smart00904
1185652001542	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
1185652001543	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1185652001544	active site
1185652001545	HIGH motif; other site
1185652001546	nucleotide binding site [chemical binding]; other site
1185652001547	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1185652001548	active site
1185652001549	KMSKS motif; other site
1185652001550	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1185652001551	tRNA binding surface [nucleotide binding]; other site
1185652001552	anticodon binding site; other site
1185652001553	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652001554	Coenzyme A binding pocket [chemical binding]; other site
1185652001555	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1185652001556	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1185652001557	RNA binding surface [nucleotide binding]; other site
1185652001558	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1185652001559	active site
1185652001560	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1185652001561	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652001562	S-adenosylmethionine binding site [chemical binding]; other site
1185652001563	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1185652001564	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1185652001565	active site
1185652001566	nucleophile elbow; other site
1185652001567	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1185652001568	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1185652001569	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
1185652001570	TrkA-N domain; Region: TrkA_N; pfam02254
1185652001571	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1185652001572	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1185652001573	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1185652001574	active site
1185652001575	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
1185652001576	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
1185652001577	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1185652001578	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1185652001579	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1185652001580	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1185652001581	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652001582	motif II; other site
1185652001583	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
1185652001584	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
1185652001585	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908
1185652001586	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1185652001587	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652001588	ATP binding site [chemical binding]; other site
1185652001589	Mg2+ binding site [ion binding]; other site
1185652001590	G-X-G motif; other site
1185652001591	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1185652001592	ATP binding site [chemical binding]; other site
1185652001593	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1185652001594	PAS fold; Region: PAS_4; pfam08448
1185652001595	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652001596	putative active site [active]
1185652001597	heme pocket [chemical binding]; other site
1185652001598	Response regulator receiver domain; Region: Response_reg; pfam00072
1185652001599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652001600	active site
1185652001601	phosphorylation site [posttranslational modification]
1185652001602	intermolecular recognition site; other site
1185652001603	dimerization interface [polypeptide binding]; other site
1185652001604	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652001605	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652001606	metal binding site [ion binding]; metal-binding site
1185652001607	active site
1185652001608	I-site; other site
1185652001609	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1185652001610	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652001611	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1185652001612	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1185652001613	dimerization interface [polypeptide binding]; other site
1185652001614	substrate binding pocket [chemical binding]; other site
1185652001615	Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253
1185652001616	dihydroxy-acid dehydratase; Validated; Region: PRK06131
1185652001617	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1185652001618	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
1185652001619	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1185652001620	active site
1185652001621	intersubunit interface [polypeptide binding]; other site
1185652001622	catalytic residue [active]
1185652001623	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
1185652001624	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
1185652001625	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1185652001626	classical (c) SDRs; Region: SDR_c; cd05233
1185652001627	NAD(P) binding site [chemical binding]; other site
1185652001628	active site
1185652001629	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1185652001630	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1185652001631	Bacterial transcriptional regulator; Region: IclR; pfam01614
1185652001632	transcriptional regulator TraR; Provisional; Region: PRK13870
1185652001633	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1185652001634	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652001635	DNA binding residues [nucleotide binding]
1185652001636	dimerization interface [polypeptide binding]; other site
1185652001637	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1185652001638	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652001639	DNA binding residues [nucleotide binding]
1185652001640	dimerization interface [polypeptide binding]; other site
1185652001641	Domain of unknown function DUF59; Region: DUF59; pfam01883
1185652001642	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1185652001643	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1185652001644	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1185652001645	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
1185652001646	Cl binding site [ion binding]; other site
1185652001647	oligomer interface [polypeptide binding]; other site
1185652001648	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
1185652001649	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
1185652001650	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1185652001651	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336
1185652001652	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1185652001653	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1185652001654	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
1185652001655	F0F1 ATP synthase subunit B'; Validated; Region: PRK09174
1185652001656	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1185652001657	F0F1 ATP synthase subunit B; Validated; Region: PRK09173
1185652001658	F0F1 ATP synthase subunit B; Provisional; Region: PRK14475
1185652001659	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1185652001660	RNA/DNA hybrid binding site [nucleotide binding]; other site
1185652001661	active site
1185652001662	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1185652001663	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1185652001664	FeS/SAM binding site; other site
1185652001665	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1185652001666	active site
1185652001667	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1185652001668	MPT binding site; other site
1185652001669	trimer interface [polypeptide binding]; other site
1185652001670	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
1185652001671	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1185652001672	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652001673	binding surface
1185652001674	TPR motif; other site
1185652001675	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
1185652001676	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652001677	binding surface
1185652001678	TPR motif; other site
1185652001679	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652001680	binding surface
1185652001681	TPR motif; other site
1185652001682	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1185652001683	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1185652001684	substrate binding pocket [chemical binding]; other site
1185652001685	chain length determination region; other site
1185652001686	substrate-Mg2+ binding site; other site
1185652001687	catalytic residues [active]
1185652001688	aspartate-rich region 1; other site
1185652001689	active site lid residues [active]
1185652001690	aspartate-rich region 2; other site
1185652001691	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
1185652001692	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1185652001693	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652001694	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1185652001695	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1185652001696	tandem repeat interface [polypeptide binding]; other site
1185652001697	oligomer interface [polypeptide binding]; other site
1185652001698	active site residues [active]
1185652001699	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1185652001700	dimer interface [polypeptide binding]; other site
1185652001701	motif 1; other site
1185652001702	active site
1185652001703	motif 2; other site
1185652001704	motif 3; other site
1185652001705	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
1185652001706	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
1185652001707	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1185652001708	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1185652001709	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1185652001710	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1185652001711	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1185652001712	Uncharacterized conserved protein [Function unknown]; Region: COG1683
1185652001713	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1185652001714	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1185652001715	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1185652001716	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1185652001717	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652001718	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652001719	metal binding site [ion binding]; metal-binding site
1185652001720	active site
1185652001721	I-site; other site
1185652001722	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1185652001723	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1185652001724	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1185652001725	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652001726	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1185652001727	putative substrate translocation pore; other site
1185652001728	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1185652001729	Helix-turn-helix domain; Region: HTH_18; pfam12833
1185652001730	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
1185652001731	UbiA prenyltransferase family; Region: UbiA; pfam01040
1185652001732	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
1185652001733	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
1185652001734	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
1185652001735	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
1185652001736	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
1185652001737	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
1185652001738	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1185652001739	FAD binding domain; Region: FAD_binding_4; pfam01565
1185652001740	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1185652001741	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1185652001742	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1185652001743	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1185652001744	[2Fe-2S] cluster binding site [ion binding]; other site
1185652001745	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
1185652001746	putative alpha subunit interface [polypeptide binding]; other site
1185652001747	putative active site [active]
1185652001748	putative substrate binding site [chemical binding]; other site
1185652001749	Fe binding site [ion binding]; other site
1185652001750	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1185652001751	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
1185652001752	FAD binding pocket [chemical binding]; other site
1185652001753	FAD binding motif [chemical binding]; other site
1185652001754	phosphate binding motif [ion binding]; other site
1185652001755	beta-alpha-beta structure motif; other site
1185652001756	NAD binding pocket [chemical binding]; other site
1185652001757	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1185652001758	catalytic loop [active]
1185652001759	iron binding site [ion binding]; other site
1185652001760	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
1185652001761	active site
1185652001762	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
1185652001763	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1185652001764	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
1185652001765	Cl binding site [ion binding]; other site
1185652001766	oligomer interface [polypeptide binding]; other site
1185652001767	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1185652001768	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1185652001769	active site
1185652001770	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1185652001771	enoyl-CoA hydratase; Provisional; Region: PRK06688
1185652001772	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1185652001773	substrate binding site [chemical binding]; other site
1185652001774	oxyanion hole (OAH) forming residues; other site
1185652001775	trimer interface [polypeptide binding]; other site
1185652001776	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
1185652001777	Cache domain; Region: Cache_1; pfam02743
1185652001778	HAMP domain; Region: HAMP; pfam00672
1185652001779	dimerization interface [polypeptide binding]; other site
1185652001780	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1185652001781	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1185652001782	dimer interface [polypeptide binding]; other site
1185652001783	putative CheW interface [polypeptide binding]; other site
1185652001784	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1185652001785	TRAM domain; Region: TRAM; cl01282
1185652001786	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652001787	S-adenosylmethionine binding site [chemical binding]; other site
1185652001788	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1185652001789	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1185652001790	RNA binding surface [nucleotide binding]; other site
1185652001791	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1185652001792	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
1185652001793	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1185652001794	TPP-binding site; other site
1185652001795	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1185652001796	PYR/PP interface [polypeptide binding]; other site
1185652001797	dimer interface [polypeptide binding]; other site
1185652001798	TPP binding site [chemical binding]; other site
1185652001799	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1185652001800	Pirin-related protein [General function prediction only]; Region: COG1741
1185652001801	Pirin; Region: Pirin; pfam02678
1185652001802	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1185652001803	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1185652001804	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1185652001805	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
1185652001806	putative active site [active]
1185652001807	Zn binding site [ion binding]; other site
1185652001808	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1185652001809	2-enoyl thioester reductase-like; Region: ETR_like; cd05282
1185652001810	NADP binding site [chemical binding]; other site
1185652001811	dimer interface [polypeptide binding]; other site
1185652001812	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1185652001813	active site 2 [active]
1185652001814	active site 1 [active]
1185652001815	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1185652001816	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
1185652001817	dimer interface [polypeptide binding]; other site
1185652001818	active site
1185652001819	acyl-CoA synthetase; Validated; Region: PRK07638
1185652001820	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1185652001821	acyl-activating enzyme (AAE) consensus motif; other site
1185652001822	AMP binding site [chemical binding]; other site
1185652001823	active site
1185652001824	CoA binding site [chemical binding]; other site
1185652001825	BioY family; Region: BioY; pfam02632
1185652001826	Cobalt transport protein; Region: CbiQ; cl00463
1185652001827	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1185652001828	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1185652001829	Walker A/P-loop; other site
1185652001830	ATP binding site [chemical binding]; other site
1185652001831	Q-loop/lid; other site
1185652001832	ABC transporter signature motif; other site
1185652001833	Walker B; other site
1185652001834	D-loop; other site
1185652001835	H-loop/switch region; other site
1185652001836	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
1185652001837	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1185652001838	protease TldD; Provisional; Region: tldD; PRK10735
1185652001839	putative acetyltransferase; Provisional; Region: PRK03624
1185652001840	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1185652001841	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1185652001842	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1185652001843	Sporulation related domain; Region: SPOR; cl10051
1185652001844	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1185652001845	Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968
1185652001846	Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968
1185652001847	putative active site [active]
1185652001848	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
1185652001849	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1185652001850	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1185652001851	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1185652001852	HSP70 interaction site [polypeptide binding]; other site
1185652001853	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1185652001854	substrate binding site [polypeptide binding]; other site
1185652001855	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
1185652001856	dimer interface [polypeptide binding]; other site
1185652001857	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
1185652001858	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1185652001859	NAD binding site [chemical binding]; other site
1185652001860	homotetramer interface [polypeptide binding]; other site
1185652001861	homodimer interface [polypeptide binding]; other site
1185652001862	substrate binding site [chemical binding]; other site
1185652001863	active site
1185652001864	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1185652001865	catalytic core [active]
1185652001866	Protein of unknown function (DUF1344); Region: DUF1344; pfam07076
1185652001867	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1185652001868	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1185652001869	Tetramer interface [polypeptide binding]; other site
1185652001870	active site
1185652001871	FMN-binding site [chemical binding]; other site
1185652001872	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1185652001873	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1185652001874	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
1185652001875	dimerization interface [polypeptide binding]; other site
1185652001876	active site
1185652001877	Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342
1185652001878	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
1185652001879	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00117
1185652001880	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1185652001881	cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007
1185652001882	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
1185652001883	Subunit I/III interface [polypeptide binding]; other site
1185652001884	D-pathway; other site
1185652001885	Subunit I/VIIc interface [polypeptide binding]; other site
1185652001886	Subunit I/IV interface [polypeptide binding]; other site
1185652001887	Subunit I/II interface [polypeptide binding]; other site
1185652001888	Low-spin heme (heme a) binding site [chemical binding]; other site
1185652001889	Subunit I/VIIa interface [polypeptide binding]; other site
1185652001890	Subunit I/VIa interface [polypeptide binding]; other site
1185652001891	Dimer interface; other site
1185652001892	Putative water exit pathway; other site
1185652001893	Binuclear center (heme a3/CuB) [ion binding]; other site
1185652001894	K-pathway; other site
1185652001895	Subunit I/Vb interface [polypeptide binding]; other site
1185652001896	Putative proton exit pathway; other site
1185652001897	Subunit I/VIb interface; other site
1185652001898	Subunit I/VIc interface [polypeptide binding]; other site
1185652001899	Electron transfer pathway; other site
1185652001900	Subunit I/VIIIb interface [polypeptide binding]; other site
1185652001901	Subunit I/VIIb interface [polypeptide binding]; other site
1185652001902	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1185652001903	UbiA prenyltransferase family; Region: UbiA; pfam01040
1185652001904	Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175
1185652001905	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
1185652001906	Subunit III/VIIa interface [polypeptide binding]; other site
1185652001907	Phospholipid binding site [chemical binding]; other site
1185652001908	Subunit I/III interface [polypeptide binding]; other site
1185652001909	Subunit III/VIb interface [polypeptide binding]; other site
1185652001910	Subunit III/VIa interface; other site
1185652001911	Subunit III/Vb interface [polypeptide binding]; other site
1185652001912	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1185652001913	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
1185652001914	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
1185652001915	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
1185652001916	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1185652001917	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1185652001918	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1185652001919	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
1185652001920	putative active site [active]
1185652001921	putative substrate binding site [chemical binding]; other site
1185652001922	ATP binding site [chemical binding]; other site
1185652001923	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1185652001924	RNA/DNA hybrid binding site [nucleotide binding]; other site
1185652001925	active site
1185652001926	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
1185652001927	catalytic triad [active]
1185652001928	dimer interface [polypeptide binding]; other site
1185652001929	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
1185652001930	hypothetical protein; Validated; Region: PRK00228
1185652001931	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
1185652001932	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1185652001933	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652001934	PAS fold; Region: PAS_3; pfam08447
1185652001935	putative active site [active]
1185652001936	heme pocket [chemical binding]; other site
1185652001937	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652001938	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652001939	metal binding site [ion binding]; metal-binding site
1185652001940	active site
1185652001941	I-site; other site
1185652001942	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1185652001943	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1185652001944	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1185652001945	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1185652001946	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1185652001947	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1185652001948	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1185652001949	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1185652001950	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652001951	catalytic residue [active]
1185652001952	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1185652001953	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1185652001954	dimerization interface [polypeptide binding]; other site
1185652001955	ligand binding site [chemical binding]; other site
1185652001956	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1185652001957	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652001958	active site
1185652001959	motif I; other site
1185652001960	motif II; other site
1185652001961	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1185652001962	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652001963	DNA-binding site [nucleotide binding]; DNA binding site
1185652001964	FCD domain; Region: FCD; pfam07729
1185652001965	Uncharacterized conserved protein [Function unknown]; Region: COG3543
1185652001966	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652001967	dimerization interface [polypeptide binding]; other site
1185652001968	putative DNA binding site [nucleotide binding]; other site
1185652001969	putative Zn2+ binding site [ion binding]; other site
1185652001970	NIPSNAP; Region: NIPSNAP; pfam07978
1185652001971	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1185652001972	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1185652001973	DNA methylase; Region: N6_N4_Mtase; pfam01555
1185652001974	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1185652001975	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
1185652001976	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652001977	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1185652001978	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1185652001979	minor groove reading motif; other site
1185652001980	helix-hairpin-helix signature motif; other site
1185652001981	substrate binding pocket [chemical binding]; other site
1185652001982	active site
1185652001983	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1185652001984	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1185652001985	DNA binding and oxoG recognition site [nucleotide binding]
1185652001986	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1185652001987	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
1185652001988	catalytic residues [active]
1185652001989	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1185652001990	putative active site [active]
1185652001991	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1185652001992	AAA domain; Region: AAA_23; pfam13476
1185652001993	Walker A/P-loop; other site
1185652001994	ATP binding site [chemical binding]; other site
1185652001995	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1185652001996	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1185652001997	ABC transporter signature motif; other site
1185652001998	Walker B; other site
1185652001999	D-loop; other site
1185652002000	H-loop/switch region; other site
1185652002001	pyruvate phosphate dikinase; Provisional; Region: PRK09279
1185652002002	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1185652002003	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1185652002004	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1185652002005	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
1185652002006	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1185652002007	Cupin domain; Region: Cupin_2; cl17218
1185652002008	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
1185652002009	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1185652002010	CysD dimerization site [polypeptide binding]; other site
1185652002011	G1 box; other site
1185652002012	putative GEF interaction site [polypeptide binding]; other site
1185652002013	GTP/Mg2+ binding site [chemical binding]; other site
1185652002014	Switch I region; other site
1185652002015	G2 box; other site
1185652002016	G3 box; other site
1185652002017	Switch II region; other site
1185652002018	G4 box; other site
1185652002019	G5 box; other site
1185652002020	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1185652002021	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1185652002022	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1185652002023	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1185652002024	Active Sites [active]
1185652002025	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1185652002026	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1185652002027	Active Sites [active]
1185652002028	choline dehydrogenase; Validated; Region: PRK02106
1185652002029	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1185652002030	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
1185652002031	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1185652002032	NAD(P) binding site [chemical binding]; other site
1185652002033	catalytic residues [active]
1185652002034	Sulfatase; Region: Sulfatase; cl17466
1185652002035	choline-sulfatase; Region: chol_sulfatase; TIGR03417
1185652002036	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
1185652002037	transcriptional regulator BetI; Validated; Region: PRK00767
1185652002038	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652002039	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1185652002040	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1185652002041	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1185652002042	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1185652002043	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652002044	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652002045	metal binding site [ion binding]; metal-binding site
1185652002046	active site
1185652002047	I-site; other site
1185652002048	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1185652002049	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1185652002050	NAD(P) binding site [chemical binding]; other site
1185652002051	Protein of unknown function (DUF3750); Region: DUF3750; pfam12570
1185652002052	L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448
1185652002053	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1185652002054	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1185652002055	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1185652002056	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198
1185652002057	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1185652002058	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1185652002059	C-terminal domain interface [polypeptide binding]; other site
1185652002060	GSH binding site (G-site) [chemical binding]; other site
1185652002061	dimer interface [polypeptide binding]; other site
1185652002062	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
1185652002063	dimer interface [polypeptide binding]; other site
1185652002064	N-terminal domain interface [polypeptide binding]; other site
1185652002065	substrate binding pocket (H-site) [chemical binding]; other site
1185652002066	Protein of unknown function (DUF419); Region: DUF419; cl15265
1185652002067	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1185652002068	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652002069	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1185652002070	dimerization interface [polypeptide binding]; other site
1185652002071	substrate binding pocket [chemical binding]; other site
1185652002072	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1185652002073	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1185652002074	putative C-terminal domain interface [polypeptide binding]; other site
1185652002075	putative GSH binding site (G-site) [chemical binding]; other site
1185652002076	putative dimer interface [polypeptide binding]; other site
1185652002077	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
1185652002078	dimer interface [polypeptide binding]; other site
1185652002079	N-terminal domain interface [polypeptide binding]; other site
1185652002080	putative substrate binding pocket (H-site) [chemical binding]; other site
1185652002081	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1185652002082	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1185652002083	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1185652002084	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652002085	putative Zn2+ binding site [ion binding]; other site
1185652002086	putative DNA binding site [nucleotide binding]; other site
1185652002087	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1185652002088	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1185652002089	PhnA protein; Region: PhnA; pfam03831
1185652002090	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
1185652002091	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1185652002092	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1185652002093	active site
1185652002094	catalytic tetrad [active]
1185652002095	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1185652002096	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652002097	motif II; other site
1185652002098	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
1185652002099	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1185652002100	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260
1185652002101	putative NAD(P) binding site [chemical binding]; other site
1185652002102	catalytic Zn binding site [ion binding]; other site
1185652002103	structural Zn binding site [ion binding]; other site
1185652002104	aminotransferase; Provisional; Region: PRK13356
1185652002105	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1185652002106	homodimer interface [polypeptide binding]; other site
1185652002107	substrate-cofactor binding pocket; other site
1185652002108	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652002109	catalytic residue [active]
1185652002110	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
1185652002111	ligand binding site [chemical binding]; other site
1185652002112	dimer interface [polypeptide binding]; other site
1185652002113	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
1185652002114	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652002115	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1185652002116	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1185652002117	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1185652002118	Predicted transcriptional regulator [Transcription]; Region: COG2378
1185652002119	HTH domain; Region: HTH_11; pfam08279
1185652002120	WYL domain; Region: WYL; pfam13280
1185652002121	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1185652002122	Cytochrome c556 [Energy production and conversion]; Region: COG3909
1185652002123	Cytochrome c; Region: Cytochrom_C; cl11414
1185652002124	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1185652002125	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1185652002126	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652002127	Coenzyme A binding pocket [chemical binding]; other site
1185652002128	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
1185652002129	DNA binding residues [nucleotide binding]
1185652002130	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
1185652002131	dimer interface [polypeptide binding]; other site
1185652002132	putative metal binding site [ion binding]; other site
1185652002133	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
1185652002134	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
1185652002135	Trp docking motif [polypeptide binding]; other site
1185652002136	putative active site [active]
1185652002137	hypothetical protein; Validated; Region: PRK00029
1185652002138	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1185652002139	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
1185652002140	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1185652002141	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1185652002142	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652002143	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
1185652002144	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
1185652002145	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1185652002146	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1185652002147	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1185652002148	putative metal binding site [ion binding]; other site
1185652002149	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1185652002150	active site
1185652002151	metal binding site [ion binding]; metal-binding site
1185652002152	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1185652002153	Ligand Binding Site [chemical binding]; other site
1185652002154	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
1185652002155	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1185652002156	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1185652002157	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1185652002158	SelR domain; Region: SelR; pfam01641
1185652002159	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
1185652002160	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1185652002161	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1185652002162	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1185652002163	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
1185652002164	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
1185652002165	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
1185652002166	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1185652002167	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
1185652002168	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
1185652002169	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
1185652002170	Predicted transcriptional regulator [Transcription]; Region: COG4957
1185652002171	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
1185652002172	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1185652002173	putative active site [active]
1185652002174	heme pocket [chemical binding]; other site
1185652002175	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652002176	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652002177	dimer interface [polypeptide binding]; other site
1185652002178	phosphorylation site [posttranslational modification]
1185652002179	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652002180	ATP binding site [chemical binding]; other site
1185652002181	Mg2+ binding site [ion binding]; other site
1185652002182	G-X-G motif; other site
1185652002183	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1185652002184	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1185652002185	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1185652002186	Uncharacterized conserved protein [Function unknown]; Region: COG5447
1185652002187	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
1185652002188	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
1185652002189	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
1185652002190	Bacterial SH3 domain; Region: SH3_3; pfam08239
1185652002191	Predicted integral membrane protein [Function unknown]; Region: COG5436
1185652002192	Uncharacterized conserved protein [Function unknown]; Region: COG5402
1185652002193	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1185652002194	Transglycosylase; Region: Transgly; pfam00912
1185652002195	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1185652002196	hypothetical protein; Provisional; Region: PRK05170
1185652002197	Protein of unknown function (DUF419); Region: DUF419; pfam04237
1185652002198	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652002199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652002200	active site
1185652002201	phosphorylation site [posttranslational modification]
1185652002202	intermolecular recognition site; other site
1185652002203	dimerization interface [polypeptide binding]; other site
1185652002204	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652002205	DNA binding site [nucleotide binding]
1185652002206	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652002207	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652002208	ATP binding site [chemical binding]; other site
1185652002209	Mg2+ binding site [ion binding]; other site
1185652002210	G-X-G motif; other site
1185652002211	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
1185652002212	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
1185652002213	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
1185652002214	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
1185652002215	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
1185652002216	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
1185652002217	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1185652002218	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1185652002219	protein binding site [polypeptide binding]; other site
1185652002220	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1185652002221	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652002222	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652002223	active site
1185652002224	phosphorylation site [posttranslational modification]
1185652002225	intermolecular recognition site; other site
1185652002226	dimerization interface [polypeptide binding]; other site
1185652002227	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652002228	DNA binding site [nucleotide binding]
1185652002229	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1185652002230	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1185652002231	dimerization interface [polypeptide binding]; other site
1185652002232	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652002233	dimer interface [polypeptide binding]; other site
1185652002234	phosphorylation site [posttranslational modification]
1185652002235	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652002236	ATP binding site [chemical binding]; other site
1185652002237	Mg2+ binding site [ion binding]; other site
1185652002238	G-X-G motif; other site
1185652002239	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
1185652002240	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1185652002241	metal binding triad; other site
1185652002242	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1185652002243	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1185652002244	metal binding triad; other site
1185652002245	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652002246	PAS fold; Region: PAS_3; pfam08447
1185652002247	putative active site [active]
1185652002248	heme pocket [chemical binding]; other site
1185652002249	PAS fold; Region: PAS_7; pfam12860
1185652002250	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652002251	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652002252	dimer interface [polypeptide binding]; other site
1185652002253	phosphorylation site [posttranslational modification]
1185652002254	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652002255	ATP binding site [chemical binding]; other site
1185652002256	Mg2+ binding site [ion binding]; other site
1185652002257	G-X-G motif; other site
1185652002258	aminopeptidase N; Provisional; Region: pepN; PRK14015
1185652002259	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1185652002260	Zn binding site [ion binding]; other site
1185652002261	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1185652002262	EamA-like transporter family; Region: EamA; pfam00892
1185652002263	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1185652002264	Fe-S cluster binding site [ion binding]; other site
1185652002265	active site
1185652002266	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
1185652002267	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
1185652002268	nucleotide binding site [chemical binding]; other site
1185652002269	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1185652002270	SBD interface [polypeptide binding]; other site
1185652002271	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1185652002272	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1185652002273	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
1185652002274	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1185652002275	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1185652002276	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1185652002277	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652002278	dimer interface [polypeptide binding]; other site
1185652002279	conserved gate region; other site
1185652002280	putative PBP binding loops; other site
1185652002281	ABC-ATPase subunit interface; other site
1185652002282	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1185652002283	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652002284	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652002285	dimerization interface [polypeptide binding]; other site
1185652002286	putative DNA binding site [nucleotide binding]; other site
1185652002287	putative Zn2+ binding site [ion binding]; other site
1185652002288	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652002289	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1185652002290	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1185652002291	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1185652002292	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1185652002293	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1185652002294	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1185652002295	Ligand binding site; other site
1185652002296	Putative Catalytic site; other site
1185652002297	DXD motif; other site
1185652002298	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1185652002299	AMP nucleosidase; Provisional; Region: PRK08292
1185652002300	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
1185652002301	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
1185652002302	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1185652002303	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
1185652002304	C-terminal domain interface [polypeptide binding]; other site
1185652002305	GSH binding site (G-site) [chemical binding]; other site
1185652002306	dimer interface [polypeptide binding]; other site
1185652002307	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
1185652002308	N-terminal domain interface [polypeptide binding]; other site
1185652002309	putative dimer interface [polypeptide binding]; other site
1185652002310	active site
1185652002311	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731
1185652002312	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1185652002313	Sel1 repeat; Region: Sel1; cl02723
1185652002314	histidinol-phosphate aminotransferase; Provisional; Region: PRK08153
1185652002315	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652002316	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652002317	homodimer interface [polypeptide binding]; other site
1185652002318	catalytic residue [active]
1185652002319	PilZ domain; Region: PilZ; pfam07238
1185652002320	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1185652002321	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
1185652002322	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
1185652002323	Porin subfamily; Region: Porin_2; pfam02530
1185652002324	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1185652002325	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1185652002326	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1185652002327	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1185652002328	catalytic residue [active]
1185652002329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1185652002330	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1185652002331	dimer interface [polypeptide binding]; other site
1185652002332	active site
1185652002333	catalytic residue [active]
1185652002334	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1185652002335	SmpB-tmRNA interface; other site
1185652002336	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1185652002337	LabA_like proteins; Region: LabA; cd10911
1185652002338	putative metal binding site [ion binding]; other site
1185652002339	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1185652002340	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1185652002341	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1185652002342	Zn2+ binding site [ion binding]; other site
1185652002343	Mg2+ binding site [ion binding]; other site
1185652002344	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1185652002345	synthetase active site [active]
1185652002346	NTP binding site [chemical binding]; other site
1185652002347	metal binding site [ion binding]; metal-binding site
1185652002348	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1185652002349	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1185652002350	Protein of unknown function (DUF3563); Region: DUF3563; pfam12086
1185652002351	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216
1185652002352	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1185652002353	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1185652002354	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1185652002355	Catalytic site [active]
1185652002356	ribonuclease III; Reviewed; Region: PRK12371
1185652002357	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1185652002358	dimerization interface [polypeptide binding]; other site
1185652002359	active site
1185652002360	metal binding site [ion binding]; metal-binding site
1185652002361	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1185652002362	dsRNA binding site [nucleotide binding]; other site
1185652002363	GTPase Era; Reviewed; Region: era; PRK00089
1185652002364	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1185652002365	G1 box; other site
1185652002366	GTP/Mg2+ binding site [chemical binding]; other site
1185652002367	Switch I region; other site
1185652002368	G2 box; other site
1185652002369	Switch II region; other site
1185652002370	G3 box; other site
1185652002371	G4 box; other site
1185652002372	G5 box; other site
1185652002373	KH domain; Region: KH_2; pfam07650
1185652002374	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial  homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613
1185652002375	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1185652002376	putative active site [active]
1185652002377	catalytic site [active]
1185652002378	putative metal binding site [ion binding]; other site
1185652002379	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
1185652002380	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
1185652002381	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
1185652002382	putative dimer interface [polypeptide binding]; other site
1185652002383	N-terminal domain interface [polypeptide binding]; other site
1185652002384	putative substrate binding pocket (H-site) [chemical binding]; other site
1185652002385	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1185652002386	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652002387	S-adenosylmethionine binding site [chemical binding]; other site
1185652002388	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1185652002389	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1185652002390	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1185652002391	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1185652002392	RNA binding site [nucleotide binding]; other site
1185652002393	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1185652002394	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1185652002395	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1185652002396	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1185652002397	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652002398	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
1185652002399	putative NAD(P) binding site [chemical binding]; other site
1185652002400	active site
1185652002401	putative substrate binding site [chemical binding]; other site
1185652002402	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652002403	dimerization interface [polypeptide binding]; other site
1185652002404	putative DNA binding site [nucleotide binding]; other site
1185652002405	putative Zn2+ binding site [ion binding]; other site
1185652002406	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1185652002407	hydrophobic ligand binding site; other site
1185652002408	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1185652002409	active site
1185652002410	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1185652002411	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1185652002412	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1185652002413	Recombination protein O N terminal; Region: RecO_N; pfam11967
1185652002414	Recombination protein O C terminal; Region: RecO_C; pfam02565
1185652002415	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
1185652002416	Predicted membrane protein [Function unknown]; Region: COG5373
1185652002417	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1185652002418	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1185652002419	Zn2+ binding site [ion binding]; other site
1185652002420	Mg2+ binding site [ion binding]; other site
1185652002421	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
1185652002422	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
1185652002423	MOSC domain; Region: MOSC; pfam03473
1185652002424	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652002425	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1185652002426	putative substrate translocation pore; other site
1185652002427	quinolinate synthetase; Provisional; Region: PRK09375
1185652002428	L-aspartate oxidase; Provisional; Region: PRK07512
1185652002429	L-aspartate oxidase; Provisional; Region: PRK06175
1185652002430	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1185652002431	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
1185652002432	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1185652002433	dimerization interface [polypeptide binding]; other site
1185652002434	active site
1185652002435	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1185652002436	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1185652002437	E-class dimer interface [polypeptide binding]; other site
1185652002438	P-class dimer interface [polypeptide binding]; other site
1185652002439	active site
1185652002440	Cu2+ binding site [ion binding]; other site
1185652002441	Zn2+ binding site [ion binding]; other site
1185652002442	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
1185652002443	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
1185652002444	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
1185652002445	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
1185652002446	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1185652002447	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1185652002448	Protein of unknown function (DUF2385); Region: DUF2385; cl11490
1185652002449	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
1185652002450	nudix motif; other site
1185652002451	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1185652002452	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1185652002453	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1185652002454	active site
1185652002455	HIGH motif; other site
1185652002456	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1185652002457	KMSKS motif; other site
1185652002458	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1185652002459	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1185652002460	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1185652002461	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1185652002462	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
1185652002463	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
1185652002464	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
1185652002465	active site
1185652002466	catalytic residues [active]
1185652002467	metal binding site [ion binding]; metal-binding site
1185652002468	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1185652002469	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1185652002470	EamA-like transporter family; Region: EamA; cl17759
1185652002471	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1185652002472	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
1185652002473	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
1185652002474	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1185652002475	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1185652002476	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
1185652002477	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
1185652002478	Walker A/P-loop; other site
1185652002479	ATP binding site [chemical binding]; other site
1185652002480	Q-loop/lid; other site
1185652002481	ABC transporter signature motif; other site
1185652002482	Walker B; other site
1185652002483	D-loop; other site
1185652002484	H-loop/switch region; other site
1185652002485	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
1185652002486	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1185652002487	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1185652002488	CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009
1185652002489	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
1185652002490	classical (c) SDRs; Region: SDR_c; cd05233
1185652002491	NAD(P) binding site [chemical binding]; other site
1185652002492	active site
1185652002493	amidophosphoribosyltransferase; Provisional; Region: PRK09123
1185652002494	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1185652002495	active site
1185652002496	tetramer interface [polypeptide binding]; other site
1185652002497	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1185652002498	active site
1185652002499	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1185652002500	Colicin V production protein; Region: Colicin_V; pfam02674
1185652002501	DNA repair protein RadA; Provisional; Region: PRK11823
1185652002502	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1185652002503	Walker A motif/ATP binding site; other site
1185652002504	ATP binding site [chemical binding]; other site
1185652002505	Walker B motif; other site
1185652002506	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1185652002507	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1185652002508	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1185652002509	active site
1185652002510	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1185652002511	dimer interface [polypeptide binding]; other site
1185652002512	substrate binding site [chemical binding]; other site
1185652002513	catalytic residues [active]
1185652002514	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1185652002515	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1185652002516	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652002517	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652002518	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1185652002519	Predicted membrane protein [Function unknown]; Region: COG4541
1185652002520	replicative DNA helicase; Provisional; Region: PRK09165
1185652002521	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1185652002522	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1185652002523	Walker A motif; other site
1185652002524	ATP binding site [chemical binding]; other site
1185652002525	Walker B motif; other site
1185652002526	DNA binding loops [nucleotide binding]
1185652002527	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1185652002528	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1185652002529	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1185652002530	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1185652002531	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1185652002532	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
1185652002533	dimerization interface [polypeptide binding]; other site
1185652002534	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1185652002535	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1185652002536	active site
1185652002537	catalytic tetrad [active]
1185652002538	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1185652002539	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1185652002540	3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936
1185652002541	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1185652002542	NAD(P) binding site [chemical binding]; other site
1185652002543	homotetramer interface [polypeptide binding]; other site
1185652002544	homodimer interface [polypeptide binding]; other site
1185652002545	active site
1185652002546	acyl carrier protein; Provisional; Region: acpP; PRK00982
1185652002547	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
1185652002548	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1185652002549	dimer interface [polypeptide binding]; other site
1185652002550	active site
1185652002551	YceG-like family; Region: YceG; pfam02618
1185652002552	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1185652002553	dimerization interface [polypeptide binding]; other site
1185652002554	Uncharacterized stress-induced protein [Function unknown]; Region: COG1561
1185652002555	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1185652002556	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
1185652002557	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1185652002558	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1185652002559	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1185652002560	catalytic site [active]
1185652002561	G-X2-G-X-G-K; other site
1185652002562	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1185652002563	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652002564	S-adenosylmethionine binding site [chemical binding]; other site
1185652002565	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
1185652002566	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1185652002567	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1185652002568	SurA N-terminal domain; Region: SurA_N; pfam09312
1185652002569	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
1185652002570	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1185652002571	Predicted permeases [General function prediction only]; Region: COG0795
1185652002572	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1185652002573	Predicted permeases [General function prediction only]; Region: COG0795
1185652002574	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1185652002575	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1185652002576	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1185652002577	interface (dimer of trimers) [polypeptide binding]; other site
1185652002578	Substrate-binding/catalytic site; other site
1185652002579	Zn-binding sites [ion binding]; other site
1185652002580	DNA polymerase III subunit chi; Validated; Region: PRK05728
1185652002581	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652002582	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652002583	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652002584	Coenzyme A binding pocket [chemical binding]; other site
1185652002585	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1185652002586	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1185652002587	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1185652002588	ABC transporter; Region: ABC_tran_2; pfam12848
1185652002589	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1185652002590	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1185652002591	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1185652002592	acyl-activating enzyme (AAE) consensus motif; other site
1185652002593	AMP binding site [chemical binding]; other site
1185652002594	active site
1185652002595	CoA binding site [chemical binding]; other site
1185652002596	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
1185652002597	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
1185652002598	GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038
1185652002599	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1185652002600	putative C-terminal domain interface [polypeptide binding]; other site
1185652002601	putative GSH binding site (G-site) [chemical binding]; other site
1185652002602	putative dimer interface [polypeptide binding]; other site
1185652002603	C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202
1185652002604	putative N-terminal domain interface [polypeptide binding]; other site
1185652002605	putative dimer interface [polypeptide binding]; other site
1185652002606	putative substrate binding pocket (H-site) [chemical binding]; other site
1185652002607	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1185652002608	active site
1185652002609	multimer interface [polypeptide binding]; other site
1185652002610	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
1185652002611	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
1185652002612	CGNR zinc finger; Region: zf-CGNR; pfam11706
1185652002613	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1185652002614	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652002615	TM-ABC transporter signature motif; other site
1185652002616	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1185652002617	MoaE homodimer interface [polypeptide binding]; other site
1185652002618	MoaD interaction [polypeptide binding]; other site
1185652002619	active site residues [active]
1185652002620	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1185652002621	MoaE interaction surface [polypeptide binding]; other site
1185652002622	MoeB interaction surface [polypeptide binding]; other site
1185652002623	thiocarboxylated glycine; other site
1185652002624	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1185652002625	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1185652002626	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1185652002627	GIY-YIG motif/motif A; other site
1185652002628	active site
1185652002629	catalytic site [active]
1185652002630	putative DNA binding site [nucleotide binding]; other site
1185652002631	metal binding site [ion binding]; metal-binding site
1185652002632	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1185652002633	short chain dehydrogenase; Provisional; Region: PRK09134
1185652002634	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652002635	NAD(P) binding site [chemical binding]; other site
1185652002636	active site
1185652002637	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
1185652002638	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1185652002639	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
1185652002640	putative C-terminal domain interface [polypeptide binding]; other site
1185652002641	putative GSH binding site (G-site) [chemical binding]; other site
1185652002642	putative dimer interface [polypeptide binding]; other site
1185652002643	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
1185652002644	N-terminal domain interface [polypeptide binding]; other site
1185652002645	dimer interface [polypeptide binding]; other site
1185652002646	putative substrate binding pocket (H-site) [chemical binding]; other site
1185652002647	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
1185652002648	B1 nucleotide binding pocket [chemical binding]; other site
1185652002649	B2 nucleotide binding pocket [chemical binding]; other site
1185652002650	CAS motifs; other site
1185652002651	active site
1185652002652	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
1185652002653	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
1185652002654	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1185652002655	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
1185652002656	putative [4Fe-4S] binding site [ion binding]; other site
1185652002657	putative molybdopterin cofactor binding site [chemical binding]; other site
1185652002658	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1185652002659	molybdopterin cofactor binding site; other site
1185652002660	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1185652002661	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
1185652002662	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1185652002663	dimer interface [polypeptide binding]; other site
1185652002664	ADP-ribose binding site [chemical binding]; other site
1185652002665	active site
1185652002666	nudix motif; other site
1185652002667	metal binding site [ion binding]; metal-binding site
1185652002668	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1185652002669	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1185652002670	active site
1185652002671	substrate binding site [chemical binding]; other site
1185652002672	cosubstrate binding site; other site
1185652002673	catalytic site [active]
1185652002674	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1185652002675	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1185652002676	dimerization interface [polypeptide binding]; other site
1185652002677	putative ATP binding site [chemical binding]; other site
1185652002678	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1185652002679	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1185652002680	hypothetical protein; Validated; Region: PRK09087
1185652002681	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
1185652002682	polyphosphate kinase; Provisional; Region: PRK05443
1185652002683	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1185652002684	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1185652002685	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1185652002686	putative domain interface [polypeptide binding]; other site
1185652002687	putative active site [active]
1185652002688	catalytic site [active]
1185652002689	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1185652002690	putative domain interface [polypeptide binding]; other site
1185652002691	putative active site [active]
1185652002692	catalytic site [active]
1185652002693	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
1185652002694	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1185652002695	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
1185652002696	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652002697	cyclase homology domain; Region: CHD; cd07302
1185652002698	nucleotidyl binding site; other site
1185652002699	metal binding site [ion binding]; metal-binding site
1185652002700	dimer interface [polypeptide binding]; other site
1185652002701	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
1185652002702	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1185652002703	catalytic site [active]
1185652002704	putative active site [active]
1185652002705	putative substrate binding site [chemical binding]; other site
1185652002706	HRDC domain; Region: HRDC; pfam00570
1185652002707	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1185652002708	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1185652002709	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1185652002710	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1185652002711	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652002712	putative MFS family transporter protein; Provisional; Region: PRK03633
1185652002713	putative substrate translocation pore; other site
1185652002714	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1185652002715	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1185652002716	dimer interface [polypeptide binding]; other site
1185652002717	anticodon binding site; other site
1185652002718	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1185652002719	homodimer interface [polypeptide binding]; other site
1185652002720	motif 1; other site
1185652002721	active site
1185652002722	motif 2; other site
1185652002723	GAD domain; Region: GAD; pfam02938
1185652002724	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1185652002725	active site
1185652002726	motif 3; other site
1185652002727	Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447
1185652002728	active site
1185652002729	catalytic residue [active]
1185652002730	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1185652002731	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1185652002732	ring oligomerisation interface [polypeptide binding]; other site
1185652002733	ATP/Mg binding site [chemical binding]; other site
1185652002734	stacking interactions; other site
1185652002735	hinge regions; other site
1185652002736	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1185652002737	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1185652002738	CAP-like domain; other site
1185652002739	active site
1185652002740	primary dimer interface [polypeptide binding]; other site
1185652002741	EamA-like transporter family; Region: EamA; pfam00892
1185652002742	Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935
1185652002743	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
1185652002744	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
1185652002745	Predicted membrane protein/domain [Function unknown]; Region: COG1714
1185652002746	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
1185652002747	dimer interface [polypeptide binding]; other site
1185652002748	allosteric magnesium binding site [ion binding]; other site
1185652002749	active site
1185652002750	aspartate-rich active site metal binding site; other site
1185652002751	Schiff base residues; other site
1185652002752	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1185652002753	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1185652002754	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
1185652002755	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1185652002756	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1185652002757	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1185652002758	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1185652002759	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1185652002760	dimer interface [polypeptide binding]; other site
1185652002761	active site
1185652002762	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1185652002763	folate binding site [chemical binding]; other site
1185652002764	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1185652002765	ATP cone domain; Region: ATP-cone; pfam03477
1185652002766	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1185652002767	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1185652002768	catalytic motif [active]
1185652002769	Zn binding site [ion binding]; other site
1185652002770	RibD C-terminal domain; Region: RibD_C; cl17279
1185652002771	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1185652002772	Lumazine binding domain; Region: Lum_binding; pfam00677
1185652002773	Lumazine binding domain; Region: Lum_binding; pfam00677
1185652002774	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1185652002775	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1185652002776	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1185652002777	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1185652002778	Cupin domain; Region: Cupin_2; cl17218
1185652002779	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1185652002780	homopentamer interface [polypeptide binding]; other site
1185652002781	active site
1185652002782	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1185652002783	putative RNA binding site [nucleotide binding]; other site
1185652002784	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652002785	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1185652002786	putative substrate translocation pore; other site
1185652002787	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808
1185652002788	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
1185652002789	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
1185652002790	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
1185652002791	Uncharacterized conserved protein [Function unknown]; Region: COG5452
1185652002792	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
1185652002793	putative phosphate acyltransferase; Provisional; Region: PRK05331
1185652002794	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1185652002795	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1185652002796	dimer interface [polypeptide binding]; other site
1185652002797	active site
1185652002798	CoA binding pocket [chemical binding]; other site
1185652002799	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1185652002800	IHF dimer interface [polypeptide binding]; other site
1185652002801	IHF - DNA interface [nucleotide binding]; other site
1185652002802	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
1185652002803	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1185652002804	DNA binding residues [nucleotide binding]
1185652002805	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1185652002806	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824
1185652002807	putative hydrophobic ligand binding site [chemical binding]; other site
1185652002808	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
1185652002809	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1185652002810	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1185652002811	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1185652002812	potassium-transporting ATPase subunit C; Provisional; Region: PRK13999
1185652002813	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1185652002814	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1185652002815	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1185652002816	Ligand Binding Site [chemical binding]; other site
1185652002817	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
1185652002818	GAF domain; Region: GAF_3; pfam13492
1185652002819	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652002820	dimer interface [polypeptide binding]; other site
1185652002821	phosphorylation site [posttranslational modification]
1185652002822	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652002823	ATP binding site [chemical binding]; other site
1185652002824	Mg2+ binding site [ion binding]; other site
1185652002825	G-X-G motif; other site
1185652002826	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652002827	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652002828	active site
1185652002829	phosphorylation site [posttranslational modification]
1185652002830	intermolecular recognition site; other site
1185652002831	dimerization interface [polypeptide binding]; other site
1185652002832	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652002833	DNA binding site [nucleotide binding]
1185652002834	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1185652002835	tetramerization interface [polypeptide binding]; other site
1185652002836	active site
1185652002837	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1185652002838	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652002839	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652002840	dimerization interface [polypeptide binding]; other site
1185652002841	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1185652002842	active site
1185652002843	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
1185652002844	putative catalytic residues [active]
1185652002845	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652002846	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1185652002847	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
1185652002848	[2Fe-2S] cluster binding site [ion binding]; other site
1185652002849	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1185652002850	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
1185652002851	dimer interface [polypeptide binding]; other site
1185652002852	active site
1185652002853	heme binding site [chemical binding]; other site
1185652002854	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
1185652002855	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1185652002856	Helix-turn-helix domain; Region: HTH_18; pfam12833
1185652002857	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652002858	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
1185652002859	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1185652002860	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1185652002861	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1185652002862	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652002863	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1185652002864	TM-ABC transporter signature motif; other site
1185652002865	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1185652002866	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1185652002867	TM-ABC transporter signature motif; other site
1185652002868	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1185652002869	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1185652002870	Walker A/P-loop; other site
1185652002871	ATP binding site [chemical binding]; other site
1185652002872	Q-loop/lid; other site
1185652002873	ABC transporter signature motif; other site
1185652002874	Walker B; other site
1185652002875	D-loop; other site
1185652002876	H-loop/switch region; other site
1185652002877	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1185652002878	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1185652002879	Walker A/P-loop; other site
1185652002880	ATP binding site [chemical binding]; other site
1185652002881	Q-loop/lid; other site
1185652002882	ABC transporter signature motif; other site
1185652002883	Walker B; other site
1185652002884	D-loop; other site
1185652002885	H-loop/switch region; other site
1185652002886	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1185652002887	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
1185652002888	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
1185652002889	active site
1185652002890	catalytic site [active]
1185652002891	tetramer interface [polypeptide binding]; other site
1185652002892	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
1185652002893	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1185652002894	active site
1185652002895	homotetramer interface [polypeptide binding]; other site
1185652002896	Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630
1185652002897	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1185652002898	catalytic loop [active]
1185652002899	iron binding site [ion binding]; other site
1185652002900	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1185652002901	FAD binding domain; Region: FAD_binding_4; pfam01565
1185652002902	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
1185652002903	Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631
1185652002904	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1185652002905	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1185652002906	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1185652002907	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
1185652002908	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1185652002909	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1185652002910	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1185652002911	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652002912	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652002913	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1185652002914	putative effector binding pocket; other site
1185652002915	dimerization interface [polypeptide binding]; other site
1185652002916	Predicted membrane protein [Function unknown]; Region: COG3748
1185652002917	Protein of unknown function (DUF989); Region: DUF989; pfam06181
1185652002918	Cytochrome c; Region: Cytochrom_C; pfam00034
1185652002919	guanine deaminase; Provisional; Region: PRK09228
1185652002920	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
1185652002921	active site
1185652002922	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1185652002923	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1185652002924	putative dimer interface [polypeptide binding]; other site
1185652002925	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1185652002926	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1185652002927	putative dimer interface [polypeptide binding]; other site
1185652002928	Protein of unknown function (DUF982); Region: DUF982; pfam06169
1185652002929	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
1185652002930	Transglycosylase; Region: Transgly; pfam00912
1185652002931	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1185652002932	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
1185652002933	Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100
1185652002934	putative binding site; other site
1185652002935	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
1185652002936	MG2 domain; Region: A2M_N; pfam01835
1185652002937	Alpha-2-macroglobulin family; Region: A2M; pfam00207
1185652002938	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
1185652002939	surface patch; other site
1185652002940	thioester region; other site
1185652002941	specificity defining residues; other site
1185652002942	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
1185652002943	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1185652002944	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652002945	dimer interface [polypeptide binding]; other site
1185652002946	conserved gate region; other site
1185652002947	putative PBP binding loops; other site
1185652002948	ABC-ATPase subunit interface; other site
1185652002949	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652002950	dimer interface [polypeptide binding]; other site
1185652002951	conserved gate region; other site
1185652002952	putative PBP binding loops; other site
1185652002953	ABC-ATPase subunit interface; other site
1185652002954	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1185652002955	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1185652002956	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1185652002957	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652002958	DNA-binding site [nucleotide binding]; DNA binding site
1185652002959	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1185652002960	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
1185652002961	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1185652002962	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1185652002963	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1185652002964	intersubunit interface [polypeptide binding]; other site
1185652002965	active site
1185652002966	catalytic residue [active]
1185652002967	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1185652002968	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1185652002969	NAD(P) binding site [chemical binding]; other site
1185652002970	catalytic residues [active]
1185652002971	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1185652002972	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1185652002973	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
1185652002974	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1185652002975	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1185652002976	substrate binding site [chemical binding]; other site
1185652002977	dimer interface [polypeptide binding]; other site
1185652002978	ATP binding site [chemical binding]; other site
1185652002979	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1185652002980	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652002981	dimer interface [polypeptide binding]; other site
1185652002982	conserved gate region; other site
1185652002983	putative PBP binding loops; other site
1185652002984	ABC-ATPase subunit interface; other site
1185652002985	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652002986	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652002987	dimer interface [polypeptide binding]; other site
1185652002988	conserved gate region; other site
1185652002989	putative PBP binding loops; other site
1185652002990	ABC-ATPase subunit interface; other site
1185652002991	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652002992	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652002993	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1185652002994	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652002995	Walker A/P-loop; other site
1185652002996	ATP binding site [chemical binding]; other site
1185652002997	Q-loop/lid; other site
1185652002998	ABC transporter signature motif; other site
1185652002999	Walker B; other site
1185652003000	D-loop; other site
1185652003001	H-loop/switch region; other site
1185652003002	TOBE domain; Region: TOBE_2; pfam08402
1185652003003	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
1185652003004	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
1185652003005	Amidinotransferase; Region: Amidinotransf; cl12043
1185652003006	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1185652003007	mercuric reductase; Validated; Region: PRK06370
1185652003008	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1185652003009	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652003010	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1185652003011	Predicted membrane protein [Function unknown]; Region: COG3918
1185652003012	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1185652003013	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652003014	dimer interface [polypeptide binding]; other site
1185652003015	conserved gate region; other site
1185652003016	ABC-ATPase subunit interface; other site
1185652003017	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1185652003018	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1185652003019	Walker A/P-loop; other site
1185652003020	ATP binding site [chemical binding]; other site
1185652003021	Q-loop/lid; other site
1185652003022	ABC transporter signature motif; other site
1185652003023	Walker B; other site
1185652003024	D-loop; other site
1185652003025	H-loop/switch region; other site
1185652003026	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652003027	dimer interface [polypeptide binding]; other site
1185652003028	conserved gate region; other site
1185652003029	putative PBP binding loops; other site
1185652003030	ABC-ATPase subunit interface; other site
1185652003031	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652003032	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652003033	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1185652003034	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652003035	dimer interface [polypeptide binding]; other site
1185652003036	conserved gate region; other site
1185652003037	putative PBP binding loops; other site
1185652003038	ABC-ATPase subunit interface; other site
1185652003039	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652003040	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652003041	dimer interface [polypeptide binding]; other site
1185652003042	conserved gate region; other site
1185652003043	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1185652003044	ABC-ATPase subunit interface; other site
1185652003045	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652003046	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1185652003047	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1185652003048	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652003049	Walker A/P-loop; other site
1185652003050	ATP binding site [chemical binding]; other site
1185652003051	Q-loop/lid; other site
1185652003052	ABC transporter signature motif; other site
1185652003053	Walker B; other site
1185652003054	D-loop; other site
1185652003055	H-loop/switch region; other site
1185652003056	TOBE domain; Region: TOBE_2; pfam08402
1185652003057	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1185652003058	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652003059	Coenzyme A binding pocket [chemical binding]; other site
1185652003060	short chain dehydrogenase; Provisional; Region: PRK08339
1185652003061	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
1185652003062	putative NAD(P) binding site [chemical binding]; other site
1185652003063	putative active site [active]
1185652003064	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1185652003065	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1185652003066	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1185652003067	catalytic residue [active]
1185652003068	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1185652003069	homotrimer interaction site [polypeptide binding]; other site
1185652003070	putative active site [active]
1185652003071	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1185652003072	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652003073	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1185652003074	dimerization interface [polypeptide binding]; other site
1185652003075	substrate binding pocket [chemical binding]; other site
1185652003076	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
1185652003077	putative active site [active]
1185652003078	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1185652003079	Uncharacterized conserved protein [Function unknown]; Region: COG5476
1185652003080	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
1185652003081	MlrC C-terminus; Region: MlrC_C; pfam07171
1185652003082	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1185652003083	homotrimer interaction site [polypeptide binding]; other site
1185652003084	putative active site [active]
1185652003085	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1185652003086	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1185652003087	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1185652003088	putative active site [active]
1185652003089	short chain dehydrogenase; Provisional; Region: PRK07074
1185652003090	classical (c) SDRs; Region: SDR_c; cd05233
1185652003091	NAD(P) binding site [chemical binding]; other site
1185652003092	active site
1185652003093	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
1185652003094	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
1185652003095	active site
1185652003096	Uncharacterized conserved protein [Function unknown]; Region: COG5476
1185652003097	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
1185652003098	MlrC C-terminus; Region: MlrC_C; pfam07171
1185652003099	urocanate hydratase; Provisional; Region: PRK05414
1185652003100	N-formylglutamate amidohydrolase; Region: FGase; cl01522
1185652003101	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1185652003102	active sites [active]
1185652003103	tetramer interface [polypeptide binding]; other site
1185652003104	imidazolonepropionase; Validated; Region: PRK09356
1185652003105	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1185652003106	active site
1185652003107	Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709
1185652003108	AAA domain; Region: AAA_33; pfam13671
1185652003109	active site
1185652003110	Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454
1185652003111	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1185652003112	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
1185652003113	active site
1185652003114	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
1185652003115	ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639
1185652003116	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652003117	dimer interface [polypeptide binding]; other site
1185652003118	conserved gate region; other site
1185652003119	ABC-ATPase subunit interface; other site
1185652003120	ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639
1185652003121	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652003122	dimer interface [polypeptide binding]; other site
1185652003123	conserved gate region; other site
1185652003124	ABC-ATPase subunit interface; other site
1185652003125	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
1185652003126	Transferrin; Region: Transferrin; cl02460
1185652003127	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1185652003128	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1185652003129	Walker A/P-loop; other site
1185652003130	ATP binding site [chemical binding]; other site
1185652003131	Q-loop/lid; other site
1185652003132	ABC transporter signature motif; other site
1185652003133	Walker B; other site
1185652003134	D-loop; other site
1185652003135	H-loop/switch region; other site
1185652003136	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
1185652003137	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1185652003138	FAD binding site [chemical binding]; other site
1185652003139	substrate binding pocket [chemical binding]; other site
1185652003140	catalytic base [active]
1185652003141	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1185652003142	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1185652003143	heat shock protein 90; Provisional; Region: PRK05218
1185652003144	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652003145	ATP binding site [chemical binding]; other site
1185652003146	Mg2+ binding site [ion binding]; other site
1185652003147	G-X-G motif; other site
1185652003148	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
1185652003149	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
1185652003150	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
1185652003151	phosphate acetyltransferase; Provisional; Region: PRK11890
1185652003152	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1185652003153	propionate/acetate kinase; Provisional; Region: PRK12379
1185652003154	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
1185652003155	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1185652003156	NAD binding site [chemical binding]; other site
1185652003157	homotetramer interface [polypeptide binding]; other site
1185652003158	homodimer interface [polypeptide binding]; other site
1185652003159	substrate binding site [chemical binding]; other site
1185652003160	active site
1185652003161	succinic semialdehyde dehydrogenase; Region: PLN02278
1185652003162	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1185652003163	tetramerization interface [polypeptide binding]; other site
1185652003164	NAD(P) binding site [chemical binding]; other site
1185652003165	catalytic residues [active]
1185652003166	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
1185652003167	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1185652003168	inhibitor-cofactor binding pocket; inhibition site
1185652003169	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652003170	catalytic residue [active]
1185652003171	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1185652003172	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1185652003173	DNA binding residues [nucleotide binding]
1185652003174	dimer interface [polypeptide binding]; other site
1185652003175	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1185652003176	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652003177	non-specific DNA binding site [nucleotide binding]; other site
1185652003178	salt bridge; other site
1185652003179	sequence-specific DNA binding site [nucleotide binding]; other site
1185652003180	Cupin domain; Region: Cupin_2; pfam07883
1185652003181	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1185652003182	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1185652003183	active site
1185652003184	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1185652003185	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1185652003186	active site
1185652003187	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1185652003188	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1185652003189	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652003190	Walker A/P-loop; other site
1185652003191	ATP binding site [chemical binding]; other site
1185652003192	Q-loop/lid; other site
1185652003193	ABC transporter signature motif; other site
1185652003194	Walker B; other site
1185652003195	D-loop; other site
1185652003196	H-loop/switch region; other site
1185652003197	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1185652003198	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1185652003199	intersubunit interface [polypeptide binding]; other site
1185652003200	active site
1185652003201	zinc binding site [ion binding]; other site
1185652003202	Na+ binding site [ion binding]; other site
1185652003203	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1185652003204	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1185652003205	peptide binding site [polypeptide binding]; other site
1185652003206	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
1185652003207	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652003208	dimer interface [polypeptide binding]; other site
1185652003209	conserved gate region; other site
1185652003210	putative PBP binding loops; other site
1185652003211	ABC-ATPase subunit interface; other site
1185652003212	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
1185652003213	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652003214	dimer interface [polypeptide binding]; other site
1185652003215	conserved gate region; other site
1185652003216	ABC-ATPase subunit interface; other site
1185652003217	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
1185652003218	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652003219	Walker A/P-loop; other site
1185652003220	ATP binding site [chemical binding]; other site
1185652003221	Q-loop/lid; other site
1185652003222	ABC transporter signature motif; other site
1185652003223	Walker B; other site
1185652003224	D-loop; other site
1185652003225	H-loop/switch region; other site
1185652003226	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652003227	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652003228	Walker A/P-loop; other site
1185652003229	ATP binding site [chemical binding]; other site
1185652003230	Q-loop/lid; other site
1185652003231	ABC transporter signature motif; other site
1185652003232	Walker B; other site
1185652003233	D-loop; other site
1185652003234	H-loop/switch region; other site
1185652003235	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652003236	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1185652003237	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1185652003238	NADP binding site [chemical binding]; other site
1185652003239	active site
1185652003240	putative substrate binding site [chemical binding]; other site
1185652003241	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1185652003242	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1185652003243	NADP-binding site; other site
1185652003244	homotetramer interface [polypeptide binding]; other site
1185652003245	substrate binding site [chemical binding]; other site
1185652003246	homodimer interface [polypeptide binding]; other site
1185652003247	active site
1185652003248	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1185652003249	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652003250	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652003251	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1185652003252	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652003253	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1185652003254	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
1185652003255	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652003256	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
1185652003257	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
1185652003258	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
1185652003259	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1185652003260	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652003261	extended (e) SDRs; Region: SDR_e; cd08946
1185652003262	NAD(P) binding site [chemical binding]; other site
1185652003263	active site
1185652003264	substrate binding site [chemical binding]; other site
1185652003265	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1185652003266	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1185652003267	active site
1185652003268	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652003269	active site
1185652003270	motif I; other site
1185652003271	motif II; other site
1185652003272	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1185652003273	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1185652003274	dimer interface [polypeptide binding]; other site
1185652003275	active site
1185652003276	Transposase; Region: HTH_Tnp_1; pfam01527
1185652003277	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1185652003278	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652003279	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1185652003280	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652003281	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1185652003282	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652003283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652003284	active site
1185652003285	phosphorylation site [posttranslational modification]
1185652003286	dimerization interface [polypeptide binding]; other site
1185652003287	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652003288	DNA binding residues [nucleotide binding]
1185652003289	dimerization interface [polypeptide binding]; other site
1185652003290	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1185652003291	MULE transposase domain; Region: MULE; pfam10551
1185652003292	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1185652003293	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1185652003294	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1185652003295	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1185652003296	Chain length determinant protein; Region: Wzz; pfam02706
1185652003297	AAA domain; Region: AAA_31; pfam13614
1185652003298	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1185652003299	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1185652003300	SLBB domain; Region: SLBB; pfam10531
1185652003301	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1185652003302	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1185652003303	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1185652003304	catalytic residues [active]
1185652003305	catalytic nucleophile [active]
1185652003306	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1185652003307	Right handed beta helix region; Region: Beta_helix; pfam13229
1185652003308	choline dehydrogenase; Validated; Region: PRK02106
1185652003309	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1185652003310	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1185652003311	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
1185652003312	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1185652003313	HprK-related kinase A; Region: HprK_rel_A; TIGR04352
1185652003314	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1185652003315	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652003316	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
1185652003317	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1185652003318	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
1185652003319	Walker A/P-loop; other site
1185652003320	ATP binding site [chemical binding]; other site
1185652003321	Q-loop/lid; other site
1185652003322	ABC transporter signature motif; other site
1185652003323	Walker B; other site
1185652003324	D-loop; other site
1185652003325	H-loop/switch region; other site
1185652003326	Right handed beta helix region; Region: Beta_helix; pfam13229
1185652003327	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652003328	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652003329	DNA binding residues [nucleotide binding]
1185652003330	dimerization interface [polypeptide binding]; other site
1185652003331	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1185652003332	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1185652003333	active site
1185652003334	substrate binding site [chemical binding]; other site
1185652003335	metal binding site [ion binding]; metal-binding site
1185652003336	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
1185652003337	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1185652003338	Substrate binding site; other site
1185652003339	Cupin domain; Region: Cupin_2; cl17218
1185652003340	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
1185652003341	dimerization interface [polypeptide binding]; other site
1185652003342	putative active cleft [active]
1185652003343	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1185652003344	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652003345	active site
1185652003346	phosphorylation site [posttranslational modification]
1185652003347	intermolecular recognition site; other site
1185652003348	dimerization interface [polypeptide binding]; other site
1185652003349	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652003350	Walker A motif; other site
1185652003351	ATP binding site [chemical binding]; other site
1185652003352	Walker B motif; other site
1185652003353	arginine finger; other site
1185652003354	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1185652003355	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1185652003356	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
1185652003357	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652003358	dimer interface [polypeptide binding]; other site
1185652003359	phosphorylation site [posttranslational modification]
1185652003360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652003361	ATP binding site [chemical binding]; other site
1185652003362	Mg2+ binding site [ion binding]; other site
1185652003363	G-X-G motif; other site
1185652003364	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1185652003365	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652003366	Zn binding site [ion binding]; other site
1185652003367	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1185652003368	Zn binding site [ion binding]; other site
1185652003369	Predicted esterase [General function prediction only]; Region: COG0400
1185652003370	TAP-like protein; Region: Abhydrolase_4; pfam08386
1185652003371	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1185652003372	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1185652003373	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1185652003374	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1185652003375	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1185652003376	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1185652003377	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1185652003378	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1185652003379	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1185652003380	Walker A/P-loop; other site
1185652003381	ATP binding site [chemical binding]; other site
1185652003382	Q-loop/lid; other site
1185652003383	ABC transporter signature motif; other site
1185652003384	Walker B; other site
1185652003385	D-loop; other site
1185652003386	H-loop/switch region; other site
1185652003387	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1185652003388	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1185652003389	Walker A/P-loop; other site
1185652003390	ATP binding site [chemical binding]; other site
1185652003391	Q-loop/lid; other site
1185652003392	ABC transporter signature motif; other site
1185652003393	Walker B; other site
1185652003394	D-loop; other site
1185652003395	H-loop/switch region; other site
1185652003396	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
1185652003397	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1185652003398	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652003399	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
1185652003400	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652003401	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
1185652003402	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
1185652003403	HPP family; Region: HPP; pfam04982
1185652003404	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1185652003405	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
1185652003406	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652003407	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1185652003408	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652003409	dimer interface [polypeptide binding]; other site
1185652003410	phosphorylation site [posttranslational modification]
1185652003411	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652003412	ATP binding site [chemical binding]; other site
1185652003413	Mg2+ binding site [ion binding]; other site
1185652003414	G-X-G motif; other site
1185652003415	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652003416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652003417	active site
1185652003418	phosphorylation site [posttranslational modification]
1185652003419	intermolecular recognition site; other site
1185652003420	dimerization interface [polypeptide binding]; other site
1185652003421	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652003422	DNA binding site [nucleotide binding]
1185652003423	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
1185652003424	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
1185652003425	Sulfatase; Region: Sulfatase; pfam00884
1185652003426	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1185652003427	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1185652003428	active site
1185652003429	metal binding site [ion binding]; metal-binding site
1185652003430	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1185652003431	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652003432	EamA-like transporter family; Region: EamA; pfam00892
1185652003433	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1185652003434	EamA-like transporter family; Region: EamA; pfam00892
1185652003435	putative phosphatase; Provisional; Region: PRK11587
1185652003436	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652003437	motif II; other site
1185652003438	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1185652003439	Part of AAA domain; Region: AAA_19; pfam13245
1185652003440	Family description; Region: UvrD_C_2; pfam13538
1185652003441	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652003442	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652003443	metal binding site [ion binding]; metal-binding site
1185652003444	active site
1185652003445	I-site; other site
1185652003446	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
1185652003447	potassium uptake protein; Region: kup; TIGR00794
1185652003448	Predicted dehydrogenase [General function prediction only]; Region: COG0579
1185652003449	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1185652003450	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
1185652003451	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652003452	active site
1185652003453	phosphorylation site [posttranslational modification]
1185652003454	intermolecular recognition site; other site
1185652003455	dimerization interface [polypeptide binding]; other site
1185652003456	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652003457	DNA binding residues [nucleotide binding]
1185652003458	dimerization interface [polypeptide binding]; other site
1185652003459	Response regulator receiver domain; Region: Response_reg; pfam00072
1185652003460	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652003461	active site
1185652003462	phosphorylation site [posttranslational modification]
1185652003463	intermolecular recognition site; other site
1185652003464	dimerization interface [polypeptide binding]; other site
1185652003465	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
1185652003466	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
1185652003467	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
1185652003468	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1185652003469	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1185652003470	catalytic residues [active]
1185652003471	catalytic nucleophile [active]
1185652003472	Presynaptic Site I dimer interface [polypeptide binding]; other site
1185652003473	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1185652003474	Synaptic Flat tetramer interface [polypeptide binding]; other site
1185652003475	Synaptic Site I dimer interface [polypeptide binding]; other site
1185652003476	DNA binding site [nucleotide binding]
1185652003477	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1185652003478	DNA-binding interface [nucleotide binding]; DNA binding site
1185652003479	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1185652003480	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
1185652003481	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1185652003482	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1185652003483	TrkA-C domain; Region: TrkA_C; pfam02080
1185652003484	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1185652003485	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1185652003486	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1185652003487	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
1185652003488	Na+/H+ antiporter 1; Region: Na_H_antiport_1; pfam06965
1185652003489	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1185652003490	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1185652003491	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1185652003492	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
1185652003493	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1185652003494	ring oligomerisation interface [polypeptide binding]; other site
1185652003495	ATP/Mg binding site [chemical binding]; other site
1185652003496	stacking interactions; other site
1185652003497	hinge regions; other site
1185652003498	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1185652003499	roof hairpin; other site
1185652003500	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1185652003501	mobile loop; other site
1185652003502	roof hairpin; other site
1185652003503	Cache domain; Region: Cache_1; pfam02743
1185652003504	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1185652003505	dimerization interface [polypeptide binding]; other site
1185652003506	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652003507	PAS fold; Region: PAS_3; pfam08447
1185652003508	putative active site [active]
1185652003509	heme pocket [chemical binding]; other site
1185652003510	PAS domain S-box; Region: sensory_box; TIGR00229
1185652003511	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652003512	putative active site [active]
1185652003513	heme pocket [chemical binding]; other site
1185652003514	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652003515	PAS fold; Region: PAS_3; pfam08447
1185652003516	putative active site [active]
1185652003517	heme pocket [chemical binding]; other site
1185652003518	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652003519	ATP binding site [chemical binding]; other site
1185652003520	Mg2+ binding site [ion binding]; other site
1185652003521	G-X-G motif; other site
1185652003522	Helix-turn-helix domain; Region: HTH_28; pfam13518
1185652003523	Winged helix-turn helix; Region: HTH_29; pfam13551
1185652003524	Homeodomain-like domain; Region: HTH_32; pfam13565
1185652003525	Integrase core domain; Region: rve; pfam00665
1185652003526	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1185652003527	Helix-turn-helix domain; Region: HTH_38; pfam13936
1185652003528	DNA-binding interface [nucleotide binding]; DNA binding site
1185652003529	Integrase core domain; Region: rve; pfam00665
1185652003530	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1185652003531	NMT1-like family; Region: NMT1_2; pfam13379
1185652003532	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1185652003533	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652003534	putative PBP binding loops; other site
1185652003535	dimer interface [polypeptide binding]; other site
1185652003536	ABC-ATPase subunit interface; other site
1185652003537	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1185652003538	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1185652003539	Walker A/P-loop; other site
1185652003540	ATP binding site [chemical binding]; other site
1185652003541	Q-loop/lid; other site
1185652003542	ABC transporter signature motif; other site
1185652003543	Walker B; other site
1185652003544	D-loop; other site
1185652003545	H-loop/switch region; other site
1185652003546	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1185652003547	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914
1185652003548	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1185652003549	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1185652003550	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652003551	Coenzyme A binding pocket [chemical binding]; other site
1185652003552	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
1185652003553	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1185652003554	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1185652003555	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652003556	active site
1185652003557	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1185652003558	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1185652003559	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1185652003560	dimerization interface [polypeptide binding]; other site
1185652003561	ligand binding site [chemical binding]; other site
1185652003562	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1185652003563	dimerization interface [polypeptide binding]; other site
1185652003564	PAS fold; Region: PAS_7; pfam12860
1185652003565	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652003566	cyclase homology domain; Region: CHD; cd07302
1185652003567	nucleotidyl binding site; other site
1185652003568	metal binding site [ion binding]; metal-binding site
1185652003569	dimer interface [polypeptide binding]; other site
1185652003570	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
1185652003571	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1185652003572	putative NAD(P) binding site [chemical binding]; other site
1185652003573	active site
1185652003574	DoxX-like family; Region: DoxX_3; pfam13781
1185652003575	Predicted integral membrane protein [Function unknown]; Region: COG5528
1185652003576	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1185652003577	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652003578	Coenzyme A binding pocket [chemical binding]; other site
1185652003579	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1185652003580	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1185652003581	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652003582	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1185652003583	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1185652003584	iron-sulfur cluster [ion binding]; other site
1185652003585	[2Fe-2S] cluster binding site [ion binding]; other site
1185652003586	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
1185652003587	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
1185652003588	DXD motif; other site
1185652003589	Cellulose synthase-like protein; Region: PLN02893
1185652003590	PilZ domain; Region: PilZ; pfam07238
1185652003591	Bacterial cellulose synthase subunit; Region: BcsB; pfam03170
1185652003592	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
1185652003593	Small integral membrane protein [Function unknown]; Region: COG5487; cl17674
1185652003594	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1185652003595	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1185652003596	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
1185652003597	Domain of unknown function (DUF1704); Region: DUF1704; cl06858
1185652003598	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
1185652003599	glutathione synthetase; Provisional; Region: PRK12458
1185652003600	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1185652003601	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1185652003602	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
1185652003603	putative ligand binding site [chemical binding]; other site
1185652003604	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1185652003605	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652003606	Walker A/P-loop; other site
1185652003607	ATP binding site [chemical binding]; other site
1185652003608	Q-loop/lid; other site
1185652003609	ABC transporter signature motif; other site
1185652003610	Walker B; other site
1185652003611	D-loop; other site
1185652003612	H-loop/switch region; other site
1185652003613	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652003614	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652003615	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652003616	TM-ABC transporter signature motif; other site
1185652003617	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652003618	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652003619	TM-ABC transporter signature motif; other site
1185652003620	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1185652003621	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652003622	DNA-binding site [nucleotide binding]; DNA binding site
1185652003623	FCD domain; Region: FCD; pfam07729
1185652003624	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1185652003625	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652003626	Walker A/P-loop; other site
1185652003627	ATP binding site [chemical binding]; other site
1185652003628	Q-loop/lid; other site
1185652003629	ABC transporter signature motif; other site
1185652003630	Walker B; other site
1185652003631	D-loop; other site
1185652003632	H-loop/switch region; other site
1185652003633	TOBE domain; Region: TOBE_2; pfam08402
1185652003634	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652003635	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652003636	dimer interface [polypeptide binding]; other site
1185652003637	conserved gate region; other site
1185652003638	putative PBP binding loops; other site
1185652003639	ABC-ATPase subunit interface; other site
1185652003640	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1185652003641	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652003642	dimer interface [polypeptide binding]; other site
1185652003643	conserved gate region; other site
1185652003644	putative PBP binding loops; other site
1185652003645	ABC-ATPase subunit interface; other site
1185652003646	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652003647	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652003648	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1185652003649	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1185652003650	DNA interaction; other site
1185652003651	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652003652	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652003653	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652003654	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652003655	DNA binding site [nucleotide binding]
1185652003656	domain linker motif; other site
1185652003657	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
1185652003658	ligand binding site [chemical binding]; other site
1185652003659	Predicted transcriptional regulator [Transcription]; Region: COG4189
1185652003660	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652003661	putative DNA binding site [nucleotide binding]; other site
1185652003662	dimerization interface [polypeptide binding]; other site
1185652003663	putative Zn2+ binding site [ion binding]; other site
1185652003664	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652003665	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652003666	dimer interface [polypeptide binding]; other site
1185652003667	conserved gate region; other site
1185652003668	putative PBP binding loops; other site
1185652003669	ABC-ATPase subunit interface; other site
1185652003670	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652003671	dimer interface [polypeptide binding]; other site
1185652003672	conserved gate region; other site
1185652003673	putative PBP binding loops; other site
1185652003674	ABC-ATPase subunit interface; other site
1185652003675	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652003676	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652003677	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1185652003678	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652003679	Walker A/P-loop; other site
1185652003680	ATP binding site [chemical binding]; other site
1185652003681	Q-loop/lid; other site
1185652003682	ABC transporter signature motif; other site
1185652003683	Walker B; other site
1185652003684	D-loop; other site
1185652003685	H-loop/switch region; other site
1185652003686	TOBE domain; Region: TOBE_2; pfam08402
1185652003687	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
1185652003688	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
1185652003689	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
1185652003690	Peptidase family M50; Region: Peptidase_M50; pfam02163
1185652003691	active site
1185652003692	putative substrate binding region [chemical binding]; other site
1185652003693	FOG: CBS domain [General function prediction only]; Region: COG0517
1185652003694	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639
1185652003695	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1185652003696	protein binding site [polypeptide binding]; other site
1185652003697	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
1185652003698	Domain interface; other site
1185652003699	Peptide binding site; other site
1185652003700	Active site tetrad [active]
1185652003701	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652003702	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652003703	TM-ABC transporter signature motif; other site
1185652003704	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1185652003705	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652003706	Walker A/P-loop; other site
1185652003707	ATP binding site [chemical binding]; other site
1185652003708	Q-loop/lid; other site
1185652003709	ABC transporter signature motif; other site
1185652003710	Walker B; other site
1185652003711	D-loop; other site
1185652003712	H-loop/switch region; other site
1185652003713	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652003714	extended (e) SDRs; Region: SDR_e; cd08946
1185652003715	NAD(P) binding site [chemical binding]; other site
1185652003716	active site
1185652003717	substrate binding site [chemical binding]; other site
1185652003718	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652003719	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1185652003720	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1185652003721	ligand binding site [chemical binding]; other site
1185652003722	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1185652003723	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
1185652003724	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
1185652003725	active site
1185652003726	catalytic residues [active]
1185652003727	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652003728	PAS domain; Region: PAS_9; pfam13426
1185652003729	putative active site [active]
1185652003730	heme pocket [chemical binding]; other site
1185652003731	PAS domain S-box; Region: sensory_box; TIGR00229
1185652003732	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652003733	putative active site [active]
1185652003734	heme pocket [chemical binding]; other site
1185652003735	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1185652003736	GAF domain; Region: GAF; pfam01590
1185652003737	PAS fold; Region: PAS_3; pfam08447
1185652003738	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652003739	heme pocket [chemical binding]; other site
1185652003740	putative active site [active]
1185652003741	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1185652003742	HWE histidine kinase; Region: HWE_HK; pfam07536
1185652003743	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1185652003744	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1185652003745	active site
1185652003746	phosphorylation site [posttranslational modification]
1185652003747	dimerization interface [polypeptide binding]; other site
1185652003748	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1185652003749	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652003750	Walker A/P-loop; other site
1185652003751	ATP binding site [chemical binding]; other site
1185652003752	Q-loop/lid; other site
1185652003753	ABC transporter signature motif; other site
1185652003754	Walker B; other site
1185652003755	D-loop; other site
1185652003756	H-loop/switch region; other site
1185652003757	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1185652003758	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652003759	Walker A/P-loop; other site
1185652003760	ATP binding site [chemical binding]; other site
1185652003761	Q-loop/lid; other site
1185652003762	ABC transporter signature motif; other site
1185652003763	Walker B; other site
1185652003764	D-loop; other site
1185652003765	H-loop/switch region; other site
1185652003766	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652003767	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1185652003768	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1185652003769	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652003770	ABC-ATPase subunit interface; other site
1185652003771	putative PBP binding loops; other site
1185652003772	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1185652003773	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652003774	dimer interface [polypeptide binding]; other site
1185652003775	conserved gate region; other site
1185652003776	putative PBP binding loops; other site
1185652003777	ABC-ATPase subunit interface; other site
1185652003778	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1185652003779	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
1185652003780	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1185652003781	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652003782	DNA-binding site [nucleotide binding]; DNA binding site
1185652003783	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1185652003784	D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312
1185652003785	mannonate dehydratase; Region: uxuA; TIGR00695
1185652003786	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1185652003787	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652003788	DNA-binding site [nucleotide binding]; DNA binding site
1185652003789	FCD domain; Region: FCD; pfam07729
1185652003790	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1185652003791	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652003792	Walker A/P-loop; other site
1185652003793	ATP binding site [chemical binding]; other site
1185652003794	Q-loop/lid; other site
1185652003795	ABC transporter signature motif; other site
1185652003796	Walker B; other site
1185652003797	D-loop; other site
1185652003798	H-loop/switch region; other site
1185652003799	TOBE domain; Region: TOBE_2; pfam08402
1185652003800	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1185652003801	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652003802	ABC-ATPase subunit interface; other site
1185652003803	putative PBP binding loops; other site
1185652003804	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652003805	dimer interface [polypeptide binding]; other site
1185652003806	conserved gate region; other site
1185652003807	putative PBP binding loops; other site
1185652003808	ABC-ATPase subunit interface; other site
1185652003809	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1185652003810	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1185652003811	NIPSNAP; Region: NIPSNAP; pfam07978
1185652003812	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1185652003813	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
1185652003814	NAD(P) binding site [chemical binding]; other site
1185652003815	catalytic residues [active]
1185652003816	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1185652003817	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1185652003818	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1185652003819	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1185652003820	nudix motif; other site
1185652003821	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1185652003822	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1185652003823	nucleophilic elbow; other site
1185652003824	catalytic triad; other site
1185652003825	Amino acid synthesis; Region: AA_synth; pfam06684
1185652003826	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
1185652003827	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1185652003828	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1185652003829	putative active site [active]
1185652003830	putative substrate binding site [chemical binding]; other site
1185652003831	putative cosubstrate binding site; other site
1185652003832	catalytic site [active]
1185652003833	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
1185652003834	metal binding site [ion binding]; metal-binding site
1185652003835	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1185652003836	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1185652003837	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652003838	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
1185652003839	[2Fe-2S] cluster binding site [ion binding]; other site
1185652003840	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1185652003841	This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511
1185652003842	putative di-iron ligands [ion binding]; other site
1185652003843	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1185652003844	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652003845	DNA binding site [nucleotide binding]
1185652003846	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
1185652003847	putative ligand binding site [chemical binding]; other site
1185652003848	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1185652003849	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1185652003850	nucleotide binding site [chemical binding]; other site
1185652003851	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
1185652003852	SnoaL-like domain; Region: SnoaL_3; pfam13474
1185652003853	cytosine deaminase; Validated; Region: PRK07572
1185652003854	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1185652003855	active site
1185652003856	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
1185652003857	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1185652003858	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1185652003859	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
1185652003860	putative active site [active]
1185652003861	metal binding site [ion binding]; metal-binding site
1185652003862	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
1185652003863	BNR repeat-like domain; Region: BNR_2; pfam13088
1185652003864	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1185652003865	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1185652003866	inhibitor site; inhibition site
1185652003867	active site
1185652003868	dimer interface [polypeptide binding]; other site
1185652003869	catalytic residue [active]
1185652003870	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1185652003871	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1185652003872	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1185652003873	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652003874	dimer interface [polypeptide binding]; other site
1185652003875	conserved gate region; other site
1185652003876	putative PBP binding loops; other site
1185652003877	ABC-ATPase subunit interface; other site
1185652003878	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1185652003879	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1185652003880	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652003881	dimer interface [polypeptide binding]; other site
1185652003882	conserved gate region; other site
1185652003883	putative PBP binding loops; other site
1185652003884	ABC-ATPase subunit interface; other site
1185652003885	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1185652003886	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652003887	Walker A/P-loop; other site
1185652003888	ATP binding site [chemical binding]; other site
1185652003889	Q-loop/lid; other site
1185652003890	ABC transporter signature motif; other site
1185652003891	Walker B; other site
1185652003892	D-loop; other site
1185652003893	H-loop/switch region; other site
1185652003894	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652003895	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
1185652003896	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652003897	Walker A/P-loop; other site
1185652003898	ATP binding site [chemical binding]; other site
1185652003899	Q-loop/lid; other site
1185652003900	ABC transporter signature motif; other site
1185652003901	Walker B; other site
1185652003902	D-loop; other site
1185652003903	H-loop/switch region; other site
1185652003904	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1185652003905	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1185652003906	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1185652003907	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652003908	DNA-binding site [nucleotide binding]; DNA binding site
1185652003909	FCD domain; Region: FCD; pfam07729
1185652003910	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1185652003911	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652003912	putative substrate translocation pore; other site
1185652003913	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1185652003914	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1185652003915	dimerization interface [polypeptide binding]; other site
1185652003916	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1185652003917	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1185652003918	dimer interface [polypeptide binding]; other site
1185652003919	putative CheW interface [polypeptide binding]; other site
1185652003920	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1185652003921	Protein of unknown function (DUF982); Region: DUF982; pfam06169
1185652003922	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1185652003923	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1185652003924	putative catalytic site [active]
1185652003925	putative metal binding site [ion binding]; other site
1185652003926	putative phosphate binding site [ion binding]; other site
1185652003927	Predicted integral membrane protein [Function unknown]; Region: COG0392
1185652003928	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1185652003929	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
1185652003930	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1185652003931	putative active site [active]
1185652003932	putative active site [active]
1185652003933	catalytic site [active]
1185652003934	catalytic site [active]
1185652003935	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
1185652003936	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1185652003937	putative active site [active]
1185652003938	putative active site [active]
1185652003939	catalytic site [active]
1185652003940	catalytic site [active]
1185652003941	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
1185652003942	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1185652003943	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
1185652003944	active site
1185652003945	catalytic site [active]
1185652003946	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1185652003947	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
1185652003948	active site
1185652003949	catalytic triad [active]
1185652003950	dimer interface [polypeptide binding]; other site
1185652003951	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1185652003952	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652003953	Cupin; Region: Cupin_6; pfam12852
1185652003954	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652003955	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1185652003956	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652003957	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1185652003958	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1185652003959	substrate binding site [chemical binding]; other site
1185652003960	dimer interface [polypeptide binding]; other site
1185652003961	triosephosphate isomerase; Provisional; Region: PRK14565
1185652003962	catalytic triad [active]
1185652003963	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1185652003964	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1185652003965	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1185652003966	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1185652003967	Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945
1185652003968	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1185652003969	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652003970	motif II; other site
1185652003971	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652003972	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1185652003973	D-xylulose kinase; Region: XylB; TIGR01312
1185652003974	nucleotide binding site [chemical binding]; other site
1185652003975	Uncharacterized conserved protein [Function unknown]; Region: COG3347
1185652003976	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
1185652003977	glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369
1185652003978	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1185652003979	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171
1185652003980	putative ligand binding site [chemical binding]; other site
1185652003981	putative NAD binding site [chemical binding]; other site
1185652003982	catalytic site [active]
1185652003983	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1185652003984	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
1185652003985	putative N- and C-terminal domain interface [polypeptide binding]; other site
1185652003986	putative active site [active]
1185652003987	MgATP binding site [chemical binding]; other site
1185652003988	catalytic site [active]
1185652003989	metal binding site [ion binding]; metal-binding site
1185652003990	putative xylulose binding site [chemical binding]; other site
1185652003991	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1185652003992	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1185652003993	Walker A/P-loop; other site
1185652003994	ATP binding site [chemical binding]; other site
1185652003995	Q-loop/lid; other site
1185652003996	ABC transporter signature motif; other site
1185652003997	Walker B; other site
1185652003998	D-loop; other site
1185652003999	H-loop/switch region; other site
1185652004000	TOBE domain; Region: TOBE_2; pfam08402
1185652004001	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1185652004002	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652004003	Walker A/P-loop; other site
1185652004004	ATP binding site [chemical binding]; other site
1185652004005	Q-loop/lid; other site
1185652004006	ABC transporter signature motif; other site
1185652004007	Walker B; other site
1185652004008	D-loop; other site
1185652004009	H-loop/switch region; other site
1185652004010	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652004011	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1185652004012	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1185652004013	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652004014	dimer interface [polypeptide binding]; other site
1185652004015	conserved gate region; other site
1185652004016	putative PBP binding loops; other site
1185652004017	ABC-ATPase subunit interface; other site
1185652004018	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652004019	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652004020	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1185652004021	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1185652004022	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
1185652004023	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
1185652004024	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
1185652004025	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
1185652004026	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1185652004027	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1185652004028	DNA-binding site [nucleotide binding]; DNA binding site
1185652004029	RNA-binding motif; other site
1185652004030	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1185652004031	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1185652004032	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1185652004033	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
1185652004034	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652004035	NAD(P) binding site [chemical binding]; other site
1185652004036	active site
1185652004037	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
1185652004038	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652004039	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652004040	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1185652004041	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1185652004042	Right handed beta helix region; Region: Beta_helix; pfam13229
1185652004043	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1185652004044	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652004045	Walker A/P-loop; other site
1185652004046	ATP binding site [chemical binding]; other site
1185652004047	Q-loop/lid; other site
1185652004048	ABC transporter signature motif; other site
1185652004049	Walker B; other site
1185652004050	D-loop; other site
1185652004051	H-loop/switch region; other site
1185652004052	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652004053	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652004054	dimer interface [polypeptide binding]; other site
1185652004055	conserved gate region; other site
1185652004056	putative PBP binding loops; other site
1185652004057	ABC-ATPase subunit interface; other site
1185652004058	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652004059	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652004060	DNA binding site [nucleotide binding]
1185652004061	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1185652004062	ligand binding site [chemical binding]; other site
1185652004063	dimerization interface [polypeptide binding]; other site
1185652004064	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1185652004065	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1185652004066	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
1185652004067	Walker A/P-loop; other site
1185652004068	ATP binding site [chemical binding]; other site
1185652004069	Q-loop/lid; other site
1185652004070	ABC transporter signature motif; other site
1185652004071	Walker B; other site
1185652004072	D-loop; other site
1185652004073	H-loop/switch region; other site
1185652004074	PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; cl17608
1185652004075	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
1185652004076	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1185652004077	DXD motif; other site
1185652004078	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1185652004079	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1185652004080	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652004081	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652004082	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652004083	metal binding site [ion binding]; metal-binding site
1185652004084	active site
1185652004085	I-site; other site
1185652004086	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1185652004087	Uncharacterized conserved protein [Function unknown]; Region: COG5439
1185652004088	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1185652004089	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652004090	S-adenosylmethionine binding site [chemical binding]; other site
1185652004091	Cache domain; Region: Cache_1; pfam02743
1185652004092	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1185652004093	dimerization interface [polypeptide binding]; other site
1185652004094	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1185652004095	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1185652004096	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381
1185652004097	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1185652004098	anti sigma factor interaction site; other site
1185652004099	regulatory phosphorylation site [posttranslational modification]; other site
1185652004100	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1185652004101	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652004102	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
1185652004103	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652004104	NAD binding site [chemical binding]; other site
1185652004105	putative substrate binding site 2 [chemical binding]; other site
1185652004106	putative substrate binding site 1 [chemical binding]; other site
1185652004107	active site
1185652004108	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1185652004109	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1185652004110	NAD binding site [chemical binding]; other site
1185652004111	homodimer interface [polypeptide binding]; other site
1185652004112	active site
1185652004113	substrate binding site [chemical binding]; other site
1185652004114	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
1185652004115	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1185652004116	active site
1185652004117	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
1185652004118	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1185652004119	ArsC family; Region: ArsC; pfam03960
1185652004120	catalytic residues [active]
1185652004121	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
1185652004122	putative active site [active]
1185652004123	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652004124	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652004125	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1185652004126	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1185652004127	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1185652004128	metal binding site [ion binding]; metal-binding site
1185652004129	Protein of unknown function (DUF993); Region: DUF993; pfam06187
1185652004130	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652004131	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652004132	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
1185652004133	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652004134	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652004135	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652004136	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1185652004137	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652004138	dimer interface [polypeptide binding]; other site
1185652004139	conserved gate region; other site
1185652004140	putative PBP binding loops; other site
1185652004141	ABC-ATPase subunit interface; other site
1185652004142	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652004143	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652004144	dimer interface [polypeptide binding]; other site
1185652004145	conserved gate region; other site
1185652004146	putative PBP binding loops; other site
1185652004147	ABC-ATPase subunit interface; other site
1185652004148	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652004149	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652004150	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652004151	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652004152	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1185652004153	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
1185652004154	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652004155	Walker A/P-loop; other site
1185652004156	ATP binding site [chemical binding]; other site
1185652004157	Q-loop/lid; other site
1185652004158	ABC transporter signature motif; other site
1185652004159	Walker B; other site
1185652004160	D-loop; other site
1185652004161	H-loop/switch region; other site
1185652004162	TOBE domain; Region: TOBE_2; pfam08402
1185652004163	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
1185652004164	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652004165	cyclase homology domain; Region: CHD; cd07302
1185652004166	nucleotidyl binding site; other site
1185652004167	metal binding site [ion binding]; metal-binding site
1185652004168	dimer interface [polypeptide binding]; other site
1185652004169	Predicted integral membrane protein [Function unknown]; Region: COG5616
1185652004170	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
1185652004171	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652004172	TPR motif; other site
1185652004173	binding surface
1185652004174	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652004175	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652004176	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1185652004177	putative effector binding pocket; other site
1185652004178	dimerization interface [polypeptide binding]; other site
1185652004179	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1185652004180	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1185652004181	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1185652004182	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652004183	NAD(P) binding site [chemical binding]; other site
1185652004184	active site
1185652004185	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1185652004186	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1185652004187	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1185652004188	Predicted transcriptional regulator [Transcription]; Region: COG1959
1185652004189	Transcriptional regulator; Region: Rrf2; pfam02082
1185652004190	Cupin domain; Region: Cupin_2; cl17218
1185652004191	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
1185652004192	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1185652004193	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1185652004194	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1185652004195	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652004196	sequence-specific DNA binding site [nucleotide binding]; other site
1185652004197	salt bridge; other site
1185652004198	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1185652004199	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1185652004200	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1185652004201	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
1185652004202	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1185652004203	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
1185652004204	active site
1185652004205	Predicted PP-loop superfamily ATPase [General function prediction only]; Region: COG0603
1185652004206	Ligand Binding Site [chemical binding]; other site
1185652004207	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1185652004208	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1185652004209	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1185652004210	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1185652004211	Walker A/P-loop; other site
1185652004212	ATP binding site [chemical binding]; other site
1185652004213	Q-loop/lid; other site
1185652004214	ABC transporter signature motif; other site
1185652004215	Walker B; other site
1185652004216	D-loop; other site
1185652004217	H-loop/switch region; other site
1185652004218	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1185652004219	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1185652004220	NAD binding site [chemical binding]; other site
1185652004221	homodimer interface [polypeptide binding]; other site
1185652004222	active site
1185652004223	substrate binding site [chemical binding]; other site
1185652004224	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1185652004225	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1185652004226	O-Antigen ligase; Region: Wzy_C; pfam04932
1185652004227	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1185652004228	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
1185652004229	SLBB domain; Region: SLBB; pfam10531
1185652004230	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1185652004231	Exopolysaccharide production repressor; Region: SyrA; pfam11089
1185652004232	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1185652004233	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1185652004234	active site
1185652004235	Staphylococcal nuclease homologues; Region: SNc; smart00318
1185652004236	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1185652004237	Catalytic site; other site
1185652004238	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
1185652004239	lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175
1185652004240	active site
1185652004241	active site
1185652004242	catalytic residues [active]
1185652004243	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
1185652004244	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1185652004245	Ligand binding site; other site
1185652004246	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1185652004247	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1185652004248	active site
1185652004249	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1185652004250	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1185652004251	Ligand binding site; other site
1185652004252	Putative Catalytic site; other site
1185652004253	DXD motif; other site
1185652004254	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1185652004255	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1185652004256	active site
1185652004257	tetramer interface; other site
1185652004258	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
1185652004259	Chain length determinant protein; Region: Wzz; pfam02706
1185652004260	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1185652004261	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1185652004262	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1185652004263	dimer interface [polypeptide binding]; other site
1185652004264	substrate binding site [chemical binding]; other site
1185652004265	ATP binding site [chemical binding]; other site
1185652004266	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1185652004267	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
1185652004268	dimer interface [polypeptide binding]; other site
1185652004269	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1185652004270	catalytic triad [active]
1185652004271	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1185652004272	Beta-lactamase; Region: Beta-lactamase; pfam00144
1185652004273	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1185652004274	active site
1185652004275	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1185652004276	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1185652004277	putative active site [active]
1185652004278	putative metal binding site [ion binding]; other site
1185652004279	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1185652004280	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652004281	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652004282	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1185652004283	active site
1185652004284	phosphorylation site [posttranslational modification]
1185652004285	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1185652004286	intermolecular recognition site; other site
1185652004287	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652004288	DNA binding residues [nucleotide binding]
1185652004289	dimerization interface [polypeptide binding]; other site
1185652004290	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652004291	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652004292	DNA binding residues [nucleotide binding]
1185652004293	dimerization interface [polypeptide binding]; other site
1185652004294	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652004295	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652004296	active site
1185652004297	phosphorylation site [posttranslational modification]
1185652004298	intermolecular recognition site; other site
1185652004299	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652004300	DNA binding residues [nucleotide binding]
1185652004301	dimerization interface [polypeptide binding]; other site
1185652004302	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1185652004303	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652004304	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1185652004305	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652004306	Walker A/P-loop; other site
1185652004307	ATP binding site [chemical binding]; other site
1185652004308	Q-loop/lid; other site
1185652004309	ABC transporter signature motif; other site
1185652004310	Walker B; other site
1185652004311	D-loop; other site
1185652004312	H-loop/switch region; other site
1185652004313	TOBE domain; Region: TOBE_2; pfam08402
1185652004314	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
1185652004315	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
1185652004316	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652004317	dimer interface [polypeptide binding]; other site
1185652004318	putative PBP binding loops; other site
1185652004319	ABC-ATPase subunit interface; other site
1185652004320	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652004321	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652004322	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652004323	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652004324	DNA binding site [nucleotide binding]
1185652004325	domain linker motif; other site
1185652004326	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1185652004327	dimerization interface [polypeptide binding]; other site
1185652004328	ligand binding site [chemical binding]; other site
1185652004329	hypothetical protein; Provisional; Region: PRK14013
1185652004330	Protein of unknown function (DUF982); Region: DUF982; pfam06169
1185652004331	Protein of unknown function (DUF982); Region: DUF982; pfam06169
1185652004332	Low affinity iron permease; Region: Iron_permease; pfam04120
1185652004333	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1185652004334	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1185652004335	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1185652004336	classical (c) SDRs; Region: SDR_c; cd05233
1185652004337	NAD(P) binding site [chemical binding]; other site
1185652004338	active site
1185652004339	Protein of unknown function (DUF982); Region: DUF982; pfam06169
1185652004340	FOG: CBS domain [General function prediction only]; Region: COG0517
1185652004341	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
1185652004342	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1185652004343	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1185652004344	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1185652004345	DNA binding residues [nucleotide binding]
1185652004346	Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450
1185652004347	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1185652004348	Domain of unknown function DUF21; Region: DUF21; pfam01595
1185652004349	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1185652004350	Transporter associated domain; Region: CorC_HlyC; smart01091
1185652004351	metabolite-proton symporter; Region: 2A0106; TIGR00883
1185652004352	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652004353	putative substrate translocation pore; other site
1185652004354	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
1185652004355	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1185652004356	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1185652004357	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1185652004358	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1185652004359	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1185652004360	D-pathway; other site
1185652004361	Putative ubiquinol binding site [chemical binding]; other site
1185652004362	Low-spin heme (heme b) binding site [chemical binding]; other site
1185652004363	Putative water exit pathway; other site
1185652004364	Binuclear center (heme o3/CuB) [ion binding]; other site
1185652004365	K-pathway; other site
1185652004366	Putative proton exit pathway; other site
1185652004367	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1185652004368	Subunit I/III interface [polypeptide binding]; other site
1185652004369	Subunit III/IV interface [polypeptide binding]; other site
1185652004370	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
1185652004371	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
1185652004372	Protein of unknown function (DUF992); Region: DUF992; pfam06186
1185652004373	Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664
1185652004374	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652004375	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1185652004376	putative DNA binding site [nucleotide binding]; other site
1185652004377	putative Zn2+ binding site [ion binding]; other site
1185652004378	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652004379	ornithine cyclodeaminase; Validated; Region: PRK07589
1185652004380	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1185652004381	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
1185652004382	active site
1185652004383	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1185652004384	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1185652004385	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652004386	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1185652004387	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1185652004388	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652004389	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1185652004390	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1185652004391	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652004392	non-specific DNA binding site [nucleotide binding]; other site
1185652004393	salt bridge; other site
1185652004394	sequence-specific DNA binding site [nucleotide binding]; other site
1185652004395	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1185652004396	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652004397	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1185652004398	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
1185652004399	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1185652004400	TadE-like protein; Region: TadE; pfam07811
1185652004401	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1185652004402	HAMP domain; Region: HAMP; pfam00672
1185652004403	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1185652004404	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1185652004405	dimer interface [polypeptide binding]; other site
1185652004406	putative CheW interface [polypeptide binding]; other site
1185652004407	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
1185652004408	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1185652004409	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1185652004410	active site
1185652004411	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1185652004412	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
1185652004413	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1185652004414	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1185652004415	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1185652004416	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
1185652004417	putative active site [active]
1185652004418	putative metal binding site [ion binding]; other site
1185652004419	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1185652004420	O-Antigen ligase; Region: Wzy_C; pfam04932
1185652004421	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
1185652004422	Chain length determinant protein; Region: Wzz; pfam02706
1185652004423	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1185652004424	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
1185652004425	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1185652004426	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652004427	S-adenosylmethionine binding site [chemical binding]; other site
1185652004428	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1185652004429	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
1185652004430	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
1185652004431	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1185652004432	Switch I; other site
1185652004433	Switch II; other site
1185652004434	septum formation inhibitor; Reviewed; Region: minC; PRK05177
1185652004435	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1185652004436	NAD synthetase; Reviewed; Region: nadE; PRK00876
1185652004437	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1185652004438	homodimer interface [polypeptide binding]; other site
1185652004439	NAD binding pocket [chemical binding]; other site
1185652004440	ATP binding pocket [chemical binding]; other site
1185652004441	Mg binding site [ion binding]; other site
1185652004442	active-site loop [active]
1185652004443	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1185652004444	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1185652004445	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922
1185652004446	acyl-activating enzyme (AAE) consensus motif; other site
1185652004447	acyl-activating enzyme (AAE) consensus motif; other site
1185652004448	putative AMP binding site [chemical binding]; other site
1185652004449	putative active site [active]
1185652004450	putative CoA binding site [chemical binding]; other site
1185652004451	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
1185652004452	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
1185652004453	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1185652004454	active site
1185652004455	dimer interface [polypeptide binding]; other site
1185652004456	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1185652004457	Ligand Binding Site [chemical binding]; other site
1185652004458	Molecular Tunnel; other site
1185652004459	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
1185652004460	mannonate dehydratase; Provisional; Region: PRK03906
1185652004461	mannonate dehydratase; Region: uxuA; TIGR00695
1185652004462	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
1185652004463	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
1185652004464	putative NAD(P) binding site [chemical binding]; other site
1185652004465	catalytic Zn binding site [ion binding]; other site
1185652004466	DctM-like transporters; Region: DctM; pfam06808
1185652004467	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1185652004468	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1185652004469	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1185652004470	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1185652004471	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1185652004472	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652004473	DNA-binding site [nucleotide binding]; DNA binding site
1185652004474	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
1185652004475	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1185652004476	short chain dehydrogenase; Provisional; Region: PRK06114
1185652004477	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652004478	NAD(P) binding site [chemical binding]; other site
1185652004479	active site
1185652004480	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1185652004481	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652004482	Walker A/P-loop; other site
1185652004483	ATP binding site [chemical binding]; other site
1185652004484	Q-loop/lid; other site
1185652004485	ABC transporter signature motif; other site
1185652004486	Walker B; other site
1185652004487	D-loop; other site
1185652004488	H-loop/switch region; other site
1185652004489	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652004490	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1185652004491	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1185652004492	ligand binding site [chemical binding]; other site
1185652004493	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652004494	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652004495	TM-ABC transporter signature motif; other site
1185652004496	transketolase; Reviewed; Region: PRK05899
1185652004497	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1185652004498	TPP-binding site [chemical binding]; other site
1185652004499	dimer interface [polypeptide binding]; other site
1185652004500	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1185652004501	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1185652004502	PYR/PP interface [polypeptide binding]; other site
1185652004503	dimer interface [polypeptide binding]; other site
1185652004504	TPP binding site [chemical binding]; other site
1185652004505	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1185652004506	bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791
1185652004507	N- and C-terminal domain interface [polypeptide binding]; other site
1185652004508	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
1185652004509	active site
1185652004510	MgATP binding site [chemical binding]; other site
1185652004511	catalytic site [active]
1185652004512	metal binding site [ion binding]; metal-binding site
1185652004513	putative homotetramer interface [polypeptide binding]; other site
1185652004514	putative homodimer interface [polypeptide binding]; other site
1185652004515	glycerol binding site [chemical binding]; other site
1185652004516	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1185652004517	MarR family; Region: MarR_2; cl17246
1185652004518	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1185652004519	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1185652004520	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652004521	NAD(P) binding site [chemical binding]; other site
1185652004522	active site
1185652004523	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1185652004524	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1185652004525	NAD binding site [chemical binding]; other site
1185652004526	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
1185652004527	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1185652004528	dimer interface [polypeptide binding]; other site
1185652004529	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1185652004530	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1185652004531	active site
1185652004532	catalytic tetrad [active]
1185652004533	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652004534	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652004535	dimer interface [polypeptide binding]; other site
1185652004536	conserved gate region; other site
1185652004537	putative PBP binding loops; other site
1185652004538	ABC-ATPase subunit interface; other site
1185652004539	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1185652004540	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652004541	dimer interface [polypeptide binding]; other site
1185652004542	conserved gate region; other site
1185652004543	putative PBP binding loops; other site
1185652004544	ABC-ATPase subunit interface; other site
1185652004545	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652004546	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652004547	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1185652004548	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652004549	Walker A/P-loop; other site
1185652004550	ATP binding site [chemical binding]; other site
1185652004551	Q-loop/lid; other site
1185652004552	ABC transporter signature motif; other site
1185652004553	Walker B; other site
1185652004554	D-loop; other site
1185652004555	H-loop/switch region; other site
1185652004556	TOBE domain; Region: TOBE; pfam03459
1185652004557	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1185652004558	classical (c) SDRs; Region: SDR_c; cd05233
1185652004559	NAD(P) binding site [chemical binding]; other site
1185652004560	active site
1185652004561	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652004562	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
1185652004563	putative NAD(P) binding site [chemical binding]; other site
1185652004564	active site
1185652004565	putative substrate binding site [chemical binding]; other site
1185652004566	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1185652004567	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652004568	DNA-binding site [nucleotide binding]; DNA binding site
1185652004569	FCD domain; Region: FCD; pfam07729
1185652004570	putative aldolase; Validated; Region: PRK08130
1185652004571	intersubunit interface [polypeptide binding]; other site
1185652004572	active site
1185652004573	Zn2+ binding site [ion binding]; other site
1185652004574	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652004575	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652004576	DNA binding site [nucleotide binding]
1185652004577	domain linker motif; other site
1185652004578	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1185652004579	putative dimerization interface [polypeptide binding]; other site
1185652004580	putative ligand binding site [chemical binding]; other site
1185652004581	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1185652004582	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652004583	putative substrate translocation pore; other site
1185652004584	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1185652004585	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1185652004586	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
1185652004587	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1185652004588	Domain of Unknown Function (DUF930); Region: DUF930; pfam06059
1185652004589	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
1185652004590	ureidoglycolate hydrolase; Provisional; Region: PRK13395
1185652004591	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
1185652004592	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
1185652004593	MOFRL family; Region: MOFRL; pfam05161
1185652004594	tartronate semialdehyde reductase; Provisional; Region: PRK15059
1185652004595	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1185652004596	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
1185652004597	glyoxylate carboligase; Provisional; Region: PRK11269
1185652004598	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1185652004599	PYR/PP interface [polypeptide binding]; other site
1185652004600	dimer interface [polypeptide binding]; other site
1185652004601	TPP binding site [chemical binding]; other site
1185652004602	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1185652004603	Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006
1185652004604	TPP-binding site [chemical binding]; other site
1185652004605	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1185652004606	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1185652004607	Bacterial transcriptional regulator; Region: IclR; pfam01614
1185652004608	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1185652004609	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652004610	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
1185652004611	putative dimerization interface [polypeptide binding]; other site
1185652004612	putative substrate binding pocket [chemical binding]; other site
1185652004613	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027
1185652004614	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1185652004615	hypothetical protein; Provisional; Region: PRK11171
1185652004616	Cupin domain; Region: Cupin_2; pfam07883
1185652004617	Cupin domain; Region: Cupin_2; pfam07883
1185652004618	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
1185652004619	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
1185652004620	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1185652004621	active site
1185652004622	DNA binding site [nucleotide binding]
1185652004623	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1185652004624	DNA binding site [nucleotide binding]
1185652004625	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
1185652004626	nucleotide binding site [chemical binding]; other site
1185652004627	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
1185652004628	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1185652004629	putative DNA binding site [nucleotide binding]; other site
1185652004630	putative homodimer interface [polypeptide binding]; other site
1185652004631	TPR repeat; Region: TPR_11; pfam13414
1185652004632	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652004633	binding surface
1185652004634	TPR motif; other site
1185652004635	TPR repeat; Region: TPR_11; pfam13414
1185652004636	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
1185652004637	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1185652004638	putative catalytic site [active]
1185652004639	putative phosphate binding site [ion binding]; other site
1185652004640	active site
1185652004641	metal binding site A [ion binding]; metal-binding site
1185652004642	DNA binding site [nucleotide binding]
1185652004643	putative AP binding site [nucleotide binding]; other site
1185652004644	putative metal binding site B [ion binding]; other site
1185652004645	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1185652004646	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1185652004647	Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130
1185652004648	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1185652004649	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
1185652004650	putative ligand binding site [chemical binding]; other site
1185652004651	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1185652004652	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652004653	Walker A/P-loop; other site
1185652004654	ATP binding site [chemical binding]; other site
1185652004655	Q-loop/lid; other site
1185652004656	ABC transporter signature motif; other site
1185652004657	Walker B; other site
1185652004658	D-loop; other site
1185652004659	H-loop/switch region; other site
1185652004660	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652004661	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652004662	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652004663	TM-ABC transporter signature motif; other site
1185652004664	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
1185652004665	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652004666	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652004667	ATP binding site [chemical binding]; other site
1185652004668	Mg2+ binding site [ion binding]; other site
1185652004669	G-X-G motif; other site
1185652004670	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652004671	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652004672	active site
1185652004673	phosphorylation site [posttranslational modification]
1185652004674	intermolecular recognition site; other site
1185652004675	dimerization interface [polypeptide binding]; other site
1185652004676	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652004677	DNA binding site [nucleotide binding]
1185652004678	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1185652004679	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1185652004680	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1185652004681	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
1185652004682	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
1185652004683	FecR protein; Region: FecR; pfam04773
1185652004684	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
1185652004685	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652004686	TPR motif; other site
1185652004687	binding surface
1185652004688	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652004689	binding surface
1185652004690	TPR motif; other site
1185652004691	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1185652004692	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1185652004693	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1185652004694	HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3
1185652004695	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652004696	active site
1185652004697	motif I; other site
1185652004698	motif II; other site
1185652004699	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1185652004700	glutamine synthetase; Region: PLN02284
1185652004701	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1185652004702	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1185652004703	Protein of unknown function (DUF2735); Region: DUF2735; pfam10931
1185652004704	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1185652004705	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1185652004706	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1185652004707	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652004708	Walker A/P-loop; other site
1185652004709	ATP binding site [chemical binding]; other site
1185652004710	Q-loop/lid; other site
1185652004711	ABC transporter signature motif; other site
1185652004712	Walker B; other site
1185652004713	D-loop; other site
1185652004714	H-loop/switch region; other site
1185652004715	TOBE domain; Region: TOBE_2; pfam08402
1185652004716	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652004717	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652004718	dimer interface [polypeptide binding]; other site
1185652004719	conserved gate region; other site
1185652004720	putative PBP binding loops; other site
1185652004721	ABC-ATPase subunit interface; other site
1185652004722	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1185652004723	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652004724	dimer interface [polypeptide binding]; other site
1185652004725	conserved gate region; other site
1185652004726	putative PBP binding loops; other site
1185652004727	ABC-ATPase subunit interface; other site
1185652004728	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652004729	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652004730	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1185652004731	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1185652004732	active site
1185652004733	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1185652004734	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652004735	DNA-binding site [nucleotide binding]; DNA binding site
1185652004736	FCD domain; Region: FCD; pfam07729
1185652004737	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1185652004738	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1185652004739	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1185652004740	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1185652004741	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652004742	Walker A/P-loop; other site
1185652004743	ATP binding site [chemical binding]; other site
1185652004744	Q-loop/lid; other site
1185652004745	ABC transporter signature motif; other site
1185652004746	Walker B; other site
1185652004747	D-loop; other site
1185652004748	H-loop/switch region; other site
1185652004749	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652004750	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652004751	TM-ABC transporter signature motif; other site
1185652004752	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652004753	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652004754	TM-ABC transporter signature motif; other site
1185652004755	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1185652004756	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1185652004757	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
1185652004758	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
1185652004759	active site
1185652004760	zinc binding site [ion binding]; other site
1185652004761	gluconate 5-dehydrogenase; Provisional; Region: PRK06124
1185652004762	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652004763	NAD(P) binding site [chemical binding]; other site
1185652004764	active site
1185652004765	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1185652004766	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
1185652004767	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1185652004768	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1185652004769	substrate binding site [chemical binding]; other site
1185652004770	oxyanion hole (OAH) forming residues; other site
1185652004771	trimer interface [polypeptide binding]; other site
1185652004772	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1185652004773	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1185652004774	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
1185652004775	substrate binding pocket [chemical binding]; other site
1185652004776	FAD binding site [chemical binding]; other site
1185652004777	catalytic base [active]
1185652004778	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1185652004779	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652004780	non-specific DNA binding site [nucleotide binding]; other site
1185652004781	salt bridge; other site
1185652004782	sequence-specific DNA binding site [nucleotide binding]; other site
1185652004783	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1185652004784	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1185652004785	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1185652004786	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1185652004787	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1185652004788	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1185652004789	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1185652004790	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1185652004791	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1185652004792	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1185652004793	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1185652004794	carboxyltransferase (CT) interaction site; other site
1185652004795	biotinylation site [posttranslational modification]; other site
1185652004796	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
1185652004797	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
1185652004798	active site
1185652004799	substrate binding site [chemical binding]; other site
1185652004800	coenzyme B12 binding site [chemical binding]; other site
1185652004801	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
1185652004802	B12 binding site [chemical binding]; other site
1185652004803	cobalt ligand [ion binding]; other site
1185652004804	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
1185652004805	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1185652004806	active site
1185652004807	oxalacetate binding site [chemical binding]; other site
1185652004808	citrylCoA binding site [chemical binding]; other site
1185652004809	coenzyme A binding site [chemical binding]; other site
1185652004810	catalytic triad [active]
1185652004811	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
1185652004812	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1185652004813	acyl-activating enzyme (AAE) consensus motif; other site
1185652004814	AMP binding site [chemical binding]; other site
1185652004815	active site
1185652004816	CoA binding site [chemical binding]; other site
1185652004817	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1185652004818	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652004819	Zn binding site [ion binding]; other site
1185652004820	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1185652004821	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1185652004822	C-terminal domain interface [polypeptide binding]; other site
1185652004823	dimer interface [polypeptide binding]; other site
1185652004824	GSH binding site (G-site) [chemical binding]; other site
1185652004825	Glutathione S-transferase, C-terminal domain; Region: GST_C_2; pfam13410
1185652004826	N-terminal domain interface [polypeptide binding]; other site
1185652004827	56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694
1185652004828	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
1185652004829	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
1185652004830	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652004831	DNA-binding site [nucleotide binding]; DNA binding site
1185652004832	UTRA domain; Region: UTRA; pfam07702
1185652004833	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
1185652004834	carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147
1185652004835	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626
1185652004836	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627
1185652004837	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
1185652004838	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652004839	Walker A/P-loop; other site
1185652004840	ATP binding site [chemical binding]; other site
1185652004841	Q-loop/lid; other site
1185652004842	ABC transporter signature motif; other site
1185652004843	Walker B; other site
1185652004844	D-loop; other site
1185652004845	H-loop/switch region; other site
1185652004846	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652004847	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
1185652004848	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652004849	Walker A/P-loop; other site
1185652004850	ATP binding site [chemical binding]; other site
1185652004851	Q-loop/lid; other site
1185652004852	ABC transporter signature motif; other site
1185652004853	Walker B; other site
1185652004854	D-loop; other site
1185652004855	H-loop/switch region; other site
1185652004856	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
1185652004857	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1185652004858	trimer interface [polypeptide binding]; other site
1185652004859	active site
1185652004860	substrate binding site [chemical binding]; other site
1185652004861	CoA binding site [chemical binding]; other site
1185652004862	dihydroxyacetone kinase; Provisional; Region: PRK14479
1185652004863	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
1185652004864	DAK2 domain; Region: Dak2; pfam02734
1185652004865	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1185652004866	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
1185652004867	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
1185652004868	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1185652004869	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1185652004870	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
1185652004871	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1185652004872	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652004873	DNA-binding site [nucleotide binding]; DNA binding site
1185652004874	FCD domain; Region: FCD; pfam07729
1185652004875	FecR protein; Region: FecR; pfam04773
1185652004876	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
1185652004877	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652004878	TPR motif; other site
1185652004879	binding surface
1185652004880	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652004881	TPR motif; other site
1185652004882	binding surface
1185652004883	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652004884	binding surface
1185652004885	TPR motif; other site
1185652004886	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1185652004887	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
1185652004888	CHASE2 domain; Region: CHASE2; pfam05226
1185652004889	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652004890	cyclase homology domain; Region: CHD; cd07302
1185652004891	nucleotidyl binding site; other site
1185652004892	metal binding site [ion binding]; metal-binding site
1185652004893	dimer interface [polypeptide binding]; other site
1185652004894	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975
1185652004895	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
1185652004896	tetramer interface [polypeptide binding]; other site
1185652004897	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
1185652004898	heterodimer interface [polypeptide binding]; other site
1185652004899	multimer interface [polypeptide binding]; other site
1185652004900	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
1185652004901	active site
1185652004902	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
1185652004903	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1185652004904	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1185652004905	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1185652004906	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652004907	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652004908	dimerization interface [polypeptide binding]; other site
1185652004909	ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049
1185652004910	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1185652004911	N-terminal plug; other site
1185652004912	ligand-binding site [chemical binding]; other site
1185652004913	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1185652004914	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1185652004915	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1185652004916	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
1185652004917	Moco binding site; other site
1185652004918	metal coordination site [ion binding]; other site
1185652004919	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1185652004920	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1185652004921	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
1185652004922	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
1185652004923	putative ADP-binding pocket [chemical binding]; other site
1185652004924	colanic acid exporter; Provisional; Region: PRK10459
1185652004925	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
1185652004926	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
1185652004927	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1185652004928	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
1185652004929	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652004930	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1185652004931	putative substrate translocation pore; other site
1185652004932	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1185652004933	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1185652004934	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652004935	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652004936	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1185652004937	NAD(P) binding site [chemical binding]; other site
1185652004938	active site
1185652004939	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652004940	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652004941	DNA binding site [nucleotide binding]
1185652004942	Predicted integral membrane protein [Function unknown]; Region: COG5616
1185652004943	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652004944	TPR motif; other site
1185652004945	TPR repeat; Region: TPR_11; pfam13414
1185652004946	binding surface
1185652004947	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1185652004948	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1185652004949	Bacterial transcriptional regulator; Region: IclR; pfam01614
1185652004950	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1185652004951	Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057
1185652004952	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
1185652004953	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1185652004954	dimer interface [polypeptide binding]; other site
1185652004955	active site
1185652004956	acylphosphatase; Provisional; Region: PRK14425
1185652004957	RNA polymerase sigma factor; Provisional; Region: PRK11922
1185652004958	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1185652004959	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1185652004960	Predicted outer membrane protein [Function unknown]; Region: COG3652
1185652004961	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
1185652004962	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
1185652004963	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1185652004964	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1185652004965	Walker A/P-loop; other site
1185652004966	ATP binding site [chemical binding]; other site
1185652004967	Q-loop/lid; other site
1185652004968	ABC transporter signature motif; other site
1185652004969	Walker B; other site
1185652004970	D-loop; other site
1185652004971	H-loop/switch region; other site
1185652004972	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1185652004973	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652004974	ABC-ATPase subunit interface; other site
1185652004975	putative PBP binding loops; other site
1185652004976	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1185652004977	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652004978	dimer interface [polypeptide binding]; other site
1185652004979	conserved gate region; other site
1185652004980	putative PBP binding loops; other site
1185652004981	ABC-ATPase subunit interface; other site
1185652004982	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1185652004983	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652004984	substrate binding pocket [chemical binding]; other site
1185652004985	membrane-bound complex binding site; other site
1185652004986	hinge residues; other site
1185652004987	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1185652004988	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652004989	DNA-binding site [nucleotide binding]; DNA binding site
1185652004990	FCD domain; Region: FCD; pfam07729
1185652004991	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1185652004992	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1185652004993	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1185652004994	Ferritin-like domain; Region: Ferritin_2; pfam13668
1185652004995	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1185652004996	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1185652004997	MarR family; Region: MarR_2; pfam12802
1185652004998	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1185652004999	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652005000	Coenzyme A binding pocket [chemical binding]; other site
1185652005001	Predicted membrane protein [Function unknown]; Region: COG2259
1185652005002	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652005003	DNA binding site [nucleotide binding]
1185652005004	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
1185652005005	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1185652005006	putative ligand binding site [chemical binding]; other site
1185652005007	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1185652005008	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1185652005009	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652005010	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652005011	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1185652005012	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
1185652005013	ParB-like nuclease domain; Region: ParB; smart00470
1185652005014	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
1185652005015	MerR family regulatory protein; Region: MerR; pfam00376
1185652005016	DNA binding residues [nucleotide binding]
1185652005017	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1185652005018	P-loop; other site
1185652005019	Magnesium ion binding site [ion binding]; other site
1185652005020	transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345
1185652005021	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1185652005022	Magnesium ion binding site [ion binding]; other site
1185652005023	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1185652005024	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
1185652005025	putative active site pocket [active]
1185652005026	metal binding site [ion binding]; metal-binding site
1185652005027	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652005028	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652005029	TM-ABC transporter signature motif; other site
1185652005030	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652005031	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652005032	TM-ABC transporter signature motif; other site
1185652005033	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1185652005034	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652005035	Walker A/P-loop; other site
1185652005036	ATP binding site [chemical binding]; other site
1185652005037	Q-loop/lid; other site
1185652005038	ABC transporter signature motif; other site
1185652005039	Walker B; other site
1185652005040	D-loop; other site
1185652005041	H-loop/switch region; other site
1185652005042	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652005043	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
1185652005044	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1185652005045	putative ligand binding site [chemical binding]; other site
1185652005046	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
1185652005047	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1185652005048	Walker A/P-loop; other site
1185652005049	ATP binding site [chemical binding]; other site
1185652005050	Q-loop/lid; other site
1185652005051	ABC transporter signature motif; other site
1185652005052	Walker B; other site
1185652005053	D-loop; other site
1185652005054	H-loop/switch region; other site
1185652005055	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
1185652005056	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1185652005057	Walker A/P-loop; other site
1185652005058	ATP binding site [chemical binding]; other site
1185652005059	Q-loop/lid; other site
1185652005060	ABC transporter signature motif; other site
1185652005061	Walker B; other site
1185652005062	D-loop; other site
1185652005063	H-loop/switch region; other site
1185652005064	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1185652005065	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1185652005066	TM-ABC transporter signature motif; other site
1185652005067	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1185652005068	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652005069	TM-ABC transporter signature motif; other site
1185652005070	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1185652005071	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
1185652005072	putative ligand binding site [chemical binding]; other site
1185652005073	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1185652005074	amphipathic channel; other site
1185652005075	Asn-Pro-Ala signature motifs; other site
1185652005076	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1185652005077	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1185652005078	active site
1185652005079	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652005080	putative DNA binding site [nucleotide binding]; other site
1185652005081	putative Zn2+ binding site [ion binding]; other site
1185652005082	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652005083	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652005084	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652005085	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1185652005086	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1185652005087	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1185652005088	protein binding site [polypeptide binding]; other site
1185652005089	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1185652005090	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1185652005091	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1185652005092	ring oligomerisation interface [polypeptide binding]; other site
1185652005093	ATP/Mg binding site [chemical binding]; other site
1185652005094	stacking interactions; other site
1185652005095	hinge regions; other site
1185652005096	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1185652005097	oligomerisation interface [polypeptide binding]; other site
1185652005098	mobile loop; other site
1185652005099	roof hairpin; other site
1185652005100	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
1185652005101	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1185652005102	putative DNA binding site [nucleotide binding]; other site
1185652005103	putative homodimer interface [polypeptide binding]; other site
1185652005104	KTSC domain; Region: KTSC; pfam13619
1185652005105	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
1185652005106	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
1185652005107	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1185652005108	active site
1185652005109	DNA binding site [nucleotide binding]
1185652005110	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1185652005111	DNA binding site [nucleotide binding]
1185652005112	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
1185652005113	nucleotide binding site [chemical binding]; other site
1185652005114	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
1185652005115	Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666
1185652005116	DNA binding site [nucleotide binding]
1185652005117	heterodimer interface [polypeptide binding]; other site
1185652005118	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
1185652005119	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
1185652005120	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652005121	S-adenosylmethionine binding site [chemical binding]; other site
1185652005122	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
1185652005123	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1185652005124	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1185652005125	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
1185652005126	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
1185652005127	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
1185652005128	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
1185652005129	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1185652005130	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
1185652005131	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
1185652005132	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
1185652005133	Bacterial SH3 domain; Region: SH3_3; pfam08239
1185652005134	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
1185652005135	putative catalytic residues [active]
1185652005136	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652005137	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652005138	DNA binding residues [nucleotide binding]
1185652005139	dimerization interface [polypeptide binding]; other site
1185652005140	glutathionine S-transferase; Provisional; Region: PRK10542
1185652005141	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1185652005142	C-terminal domain interface [polypeptide binding]; other site
1185652005143	GSH binding site (G-site) [chemical binding]; other site
1185652005144	dimer interface [polypeptide binding]; other site
1185652005145	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
1185652005146	dimer interface [polypeptide binding]; other site
1185652005147	N-terminal domain interface [polypeptide binding]; other site
1185652005148	substrate binding pocket (H-site) [chemical binding]; other site
1185652005149	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1185652005150	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1185652005151	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
1185652005152	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652005153	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1185652005154	oligomeric interface; other site
1185652005155	putative active site [active]
1185652005156	homodimer interface [polypeptide binding]; other site
1185652005157	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1185652005158	septum site-determining protein MinC; Region: minC; TIGR01222
1185652005159	Protein of unknown function, DUF393; Region: DUF393; pfam04134
1185652005160	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
1185652005161	colanic acid exporter; Provisional; Region: PRK10459
1185652005162	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
1185652005163	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1185652005164	active site
1185652005165	Uncharacterized conserved protein [Function unknown]; Region: COG5663
1185652005166	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1185652005167	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1185652005168	Bacterial sugar transferase; Region: Bac_transf; cl00939
1185652005169	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
1185652005170	aromatic arch; other site
1185652005171	DCoH dimer interaction site [polypeptide binding]; other site
1185652005172	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1185652005173	DCoH tetramer interaction site [polypeptide binding]; other site
1185652005174	substrate binding site [chemical binding]; other site
1185652005175	Hint domain; Region: Hint_2; pfam13403
1185652005176	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1185652005177	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652005178	sequence-specific DNA binding site [nucleotide binding]; other site
1185652005179	salt bridge; other site
1185652005180	Low affinity iron permease; Region: Iron_permease; cl12096
1185652005181	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652005182	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652005183	DNA binding site [nucleotide binding]
1185652005184	domain linker motif; other site
1185652005185	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1185652005186	ligand binding site [chemical binding]; other site
1185652005187	dimerization interface [polypeptide binding]; other site
1185652005188	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1185652005189	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
1185652005190	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652005191	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652005192	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1185652005193	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652005194	dimer interface [polypeptide binding]; other site
1185652005195	putative PBP binding loops; other site
1185652005196	ABC-ATPase subunit interface; other site
1185652005197	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652005198	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652005199	dimer interface [polypeptide binding]; other site
1185652005200	conserved gate region; other site
1185652005201	putative PBP binding loops; other site
1185652005202	ABC-ATPase subunit interface; other site
1185652005203	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1185652005204	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652005205	Walker A/P-loop; other site
1185652005206	ATP binding site [chemical binding]; other site
1185652005207	Q-loop/lid; other site
1185652005208	ABC transporter signature motif; other site
1185652005209	Walker B; other site
1185652005210	D-loop; other site
1185652005211	H-loop/switch region; other site
1185652005212	TOBE domain; Region: TOBE_2; pfam08402
1185652005213	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
1185652005214	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1185652005215	NADP binding site [chemical binding]; other site
1185652005216	homodimer interface [polypeptide binding]; other site
1185652005217	active site
1185652005218	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1185652005219	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
1185652005220	conserved cys residue [active]
1185652005221	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1185652005222	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1185652005223	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1185652005224	active site
1185652005225	Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140
1185652005226	Cupin domain; Region: Cupin_2; pfam07883
1185652005227	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370
1185652005228	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
1185652005229	Uncharacterized conserved protein [Function unknown]; Region: COG5441
1185652005230	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652005231	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652005232	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1185652005233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652005234	conserved gate region; other site
1185652005235	dimer interface [polypeptide binding]; other site
1185652005236	putative PBP binding loops; other site
1185652005237	ABC-ATPase subunit interface; other site
1185652005238	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652005239	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652005240	dimer interface [polypeptide binding]; other site
1185652005241	conserved gate region; other site
1185652005242	putative PBP binding loops; other site
1185652005243	ABC-ATPase subunit interface; other site
1185652005244	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1185652005245	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652005246	Walker A/P-loop; other site
1185652005247	ATP binding site [chemical binding]; other site
1185652005248	Q-loop/lid; other site
1185652005249	ABC transporter signature motif; other site
1185652005250	Walker B; other site
1185652005251	D-loop; other site
1185652005252	H-loop/switch region; other site
1185652005253	TOBE domain; Region: TOBE_2; pfam08402
1185652005254	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1185652005255	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652005256	Walker A/P-loop; other site
1185652005257	ATP binding site [chemical binding]; other site
1185652005258	Q-loop/lid; other site
1185652005259	ABC transporter signature motif; other site
1185652005260	Walker B; other site
1185652005261	D-loop; other site
1185652005262	H-loop/switch region; other site
1185652005263	TOBE domain; Region: TOBE_2; pfam08402
1185652005264	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1185652005265	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1185652005266	ligand binding site [chemical binding]; other site
1185652005267	NAD binding site [chemical binding]; other site
1185652005268	dimerization interface [polypeptide binding]; other site
1185652005269	catalytic site [active]
1185652005270	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1185652005271	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652005272	DNA-binding site [nucleotide binding]; DNA binding site
1185652005273	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1185652005274	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1185652005275	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1185652005276	active site pocket [active]
1185652005277	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1185652005278	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1185652005279	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1185652005280	DNA interaction; other site
1185652005281	Metal-binding active site; metal-binding site
1185652005282	Cupin domain; Region: Cupin_2; cl17218
1185652005283	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1185652005284	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652005285	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
1185652005286	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652005287	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1185652005288	putative substrate translocation pore; other site
1185652005289	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1185652005290	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1185652005291	NAD(P) binding site [chemical binding]; other site
1185652005292	catalytic residues [active]
1185652005293	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1185652005294	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
1185652005295	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
1185652005296	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652005297	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1185652005298	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1185652005299	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652005300	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1185652005301	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652005302	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1185652005303	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
1185652005304	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1185652005305	active site
1185652005306	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1185652005307	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1185652005308	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1185652005309	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1185652005310	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
1185652005311	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1185652005312	carboxyltransferase (CT) interaction site; other site
1185652005313	biotinylation site [posttranslational modification]; other site
1185652005314	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1185652005315	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652005316	Walker A/P-loop; other site
1185652005317	ATP binding site [chemical binding]; other site
1185652005318	Q-loop/lid; other site
1185652005319	ABC transporter signature motif; other site
1185652005320	Walker B; other site
1185652005321	D-loop; other site
1185652005322	H-loop/switch region; other site
1185652005323	TOBE domain; Region: TOBE_2; pfam08402
1185652005324	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1185652005325	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1185652005326	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
1185652005327	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652005328	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1185652005329	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1185652005330	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1185652005331	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1185652005332	acyl-activating enzyme (AAE) consensus motif; other site
1185652005333	acyl-activating enzyme (AAE) consensus motif; other site
1185652005334	putative AMP binding site [chemical binding]; other site
1185652005335	putative active site [active]
1185652005336	putative CoA binding site [chemical binding]; other site
1185652005337	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1185652005338	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1185652005339	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1185652005340	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1185652005341	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652005342	dimer interface [polypeptide binding]; other site
1185652005343	conserved gate region; other site
1185652005344	putative PBP binding loops; other site
1185652005345	ABC-ATPase subunit interface; other site
1185652005346	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652005347	dimer interface [polypeptide binding]; other site
1185652005348	conserved gate region; other site
1185652005349	putative PBP binding loops; other site
1185652005350	ABC-ATPase subunit interface; other site
1185652005351	thiolase; Provisional; Region: PRK06158
1185652005352	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1185652005353	active site
1185652005354	DUF35 OB-fold domain; Region: DUF35; pfam01796
1185652005355	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1185652005356	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652005357	NAD(P) binding site [chemical binding]; other site
1185652005358	active site
1185652005359	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652005360	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1185652005361	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
1185652005362	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
1185652005363	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1185652005364	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1185652005365	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1185652005366	succinic semialdehyde dehydrogenase; Region: PLN02278
1185652005367	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1185652005368	tetramerization interface [polypeptide binding]; other site
1185652005369	NAD(P) binding site [chemical binding]; other site
1185652005370	catalytic residues [active]
1185652005371	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1185652005372	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1185652005373	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
1185652005374	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
1185652005375	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1185652005376	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1185652005377	homodimer interface [polypeptide binding]; other site
1185652005378	NADP binding site [chemical binding]; other site
1185652005379	substrate binding site [chemical binding]; other site
1185652005380	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
1185652005381	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1185652005382	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1185652005383	putative active site [active]
1185652005384	putative substrate binding site [chemical binding]; other site
1185652005385	putative cosubstrate binding site; other site
1185652005386	catalytic site [active]
1185652005387	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1185652005388	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1185652005389	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1185652005390	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652005391	non-specific DNA binding site [nucleotide binding]; other site
1185652005392	salt bridge; other site
1185652005393	sequence-specific DNA binding site [nucleotide binding]; other site
1185652005394	Cupin domain; Region: Cupin_2; cl17218
1185652005395	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1185652005396	classical (c) SDRs; Region: SDR_c; cd05233
1185652005397	NAD(P) binding site [chemical binding]; other site
1185652005398	active site
1185652005399	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1185652005400	classical (c) SDRs; Region: SDR_c; cd05233
1185652005401	NAD(P) binding site [chemical binding]; other site
1185652005402	active site
1185652005403	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1185652005404	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1185652005405	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1185652005406	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1185652005407	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1185652005408	active site
1185652005409	lipoyl synthase; Provisional; Region: PRK05481
1185652005410	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1185652005411	FeS/SAM binding site; other site
1185652005412	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
1185652005413	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1185652005414	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1185652005415	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819
1185652005416	dimer interface [polypeptide binding]; other site
1185652005417	active site
1185652005418	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1185652005419	substrate binding site [chemical binding]; other site
1185652005420	catalytic residue [active]
1185652005421	serine racemase; Region: PLN02970
1185652005422	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1185652005423	tetramer interface [polypeptide binding]; other site
1185652005424	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652005425	catalytic residue [active]
1185652005426	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
1185652005427	homodimer interface [polypeptide binding]; other site
1185652005428	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652005429	catalytic residue [active]
1185652005430	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1185652005431	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1185652005432	Bacterial transcriptional regulator; Region: IclR; pfam01614
1185652005433	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
1185652005434	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1185652005435	Cysteine-rich domain; Region: CCG; pfam02754
1185652005436	Cysteine-rich domain; Region: CCG; pfam02754
1185652005437	FAD binding domain; Region: FAD_binding_4; pfam01565
1185652005438	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
1185652005439	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
1185652005440	FAD binding domain; Region: FAD_binding_4; pfam01565
1185652005441	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1185652005442	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652005443	DNA-binding site [nucleotide binding]; DNA binding site
1185652005444	FCD domain; Region: FCD; pfam07729
1185652005445	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1185652005446	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1185652005447	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1185652005448	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1185652005449	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1185652005450	carboxyltransferase (CT) interaction site; other site
1185652005451	biotinylation site [posttranslational modification]; other site
1185652005452	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
1185652005453	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1185652005454	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
1185652005455	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1185652005456	putative active site [active]
1185652005457	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1185652005458	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652005459	Walker A/P-loop; other site
1185652005460	ATP binding site [chemical binding]; other site
1185652005461	Q-loop/lid; other site
1185652005462	ABC transporter signature motif; other site
1185652005463	Walker B; other site
1185652005464	D-loop; other site
1185652005465	H-loop/switch region; other site
1185652005466	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652005467	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652005468	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652005469	DNA binding site [nucleotide binding]
1185652005470	domain linker motif; other site
1185652005471	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1185652005472	dimerization interface [polypeptide binding]; other site
1185652005473	ligand binding site [chemical binding]; other site
1185652005474	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652005475	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652005476	DNA binding site [nucleotide binding]
1185652005477	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1185652005478	ligand binding site [chemical binding]; other site
1185652005479	dimerization interface [polypeptide binding]; other site
1185652005480	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652005481	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652005482	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652005483	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1185652005484	dimerization interface [polypeptide binding]; other site
1185652005485	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1185652005486	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1185652005487	tetramer interface [polypeptide binding]; other site
1185652005488	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652005489	catalytic residue [active]
1185652005490	Domain of unknown function (DUF4392); Region: DUF4392; pfam14336
1185652005491	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1185652005492	hypothetical protein; Provisional; Region: PRK05463
1185652005493	Domain of unknown function (DUF336); Region: DUF336; pfam03928
1185652005494	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1185652005495	classical (c) SDRs; Region: SDR_c; cd05233
1185652005496	NAD(P) binding site [chemical binding]; other site
1185652005497	active site
1185652005498	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
1185652005499	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1185652005500	E3 interaction surface; other site
1185652005501	lipoyl attachment site [posttranslational modification]; other site
1185652005502	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1185652005503	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1185652005504	alpha subunit interface [polypeptide binding]; other site
1185652005505	TPP binding site [chemical binding]; other site
1185652005506	heterodimer interface [polypeptide binding]; other site
1185652005507	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1185652005508	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1185652005509	tetramer interface [polypeptide binding]; other site
1185652005510	heterodimer interface [polypeptide binding]; other site
1185652005511	TPP-binding site [chemical binding]; other site
1185652005512	phosphorylation loop region [posttranslational modification]
1185652005513	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652005514	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652005515	TM-ABC transporter signature motif; other site
1185652005516	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1185652005517	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
1185652005518	putative ligand binding site [chemical binding]; other site
1185652005519	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652005520	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652005521	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1185652005522	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1185652005523	classical (c) SDRs; Region: SDR_c; cd05233
1185652005524	NAD(P) binding site [chemical binding]; other site
1185652005525	active site
1185652005526	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
1185652005527	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1185652005528	E3 interaction surface; other site
1185652005529	lipoyl attachment site [posttranslational modification]; other site
1185652005530	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1185652005531	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1185652005532	alpha subunit interface [polypeptide binding]; other site
1185652005533	TPP binding site [chemical binding]; other site
1185652005534	heterodimer interface [polypeptide binding]; other site
1185652005535	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1185652005536	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1185652005537	TPP-binding site [chemical binding]; other site
1185652005538	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652005539	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652005540	TM-ABC transporter signature motif; other site
1185652005541	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1185652005542	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
1185652005543	putative ligand binding site [chemical binding]; other site
1185652005544	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1185652005545	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1185652005546	DNA interaction; other site
1185652005547	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652005548	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652005549	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1185652005550	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1185652005551	classical (c) SDRs; Region: SDR_c; cd05233
1185652005552	NAD(P) binding site [chemical binding]; other site
1185652005553	active site
1185652005554	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
1185652005555	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1185652005556	E3 interaction surface; other site
1185652005557	lipoyl attachment site [posttranslational modification]; other site
1185652005558	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1185652005559	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1185652005560	alpha subunit interface [polypeptide binding]; other site
1185652005561	TPP binding site [chemical binding]; other site
1185652005562	heterodimer interface [polypeptide binding]; other site
1185652005563	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1185652005564	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1185652005565	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1185652005566	tetramer interface [polypeptide binding]; other site
1185652005567	TPP-binding site [chemical binding]; other site
1185652005568	heterodimer interface [polypeptide binding]; other site
1185652005569	phosphorylation loop region [posttranslational modification]
1185652005570	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1185652005571	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
1185652005572	classical (c) SDRs; Region: SDR_c; cd05233
1185652005573	NAD(P) binding site [chemical binding]; other site
1185652005574	active site
1185652005575	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1185652005576	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652005577	dimer interface [polypeptide binding]; other site
1185652005578	conserved gate region; other site
1185652005579	putative PBP binding loops; other site
1185652005580	ABC-ATPase subunit interface; other site
1185652005581	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652005582	dimer interface [polypeptide binding]; other site
1185652005583	conserved gate region; other site
1185652005584	putative PBP binding loops; other site
1185652005585	ABC-ATPase subunit interface; other site
1185652005586	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1185652005587	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652005588	Walker A/P-loop; other site
1185652005589	ATP binding site [chemical binding]; other site
1185652005590	Q-loop/lid; other site
1185652005591	ABC transporter signature motif; other site
1185652005592	Walker B; other site
1185652005593	D-loop; other site
1185652005594	H-loop/switch region; other site
1185652005595	TOBE domain; Region: TOBE_2; pfam08402
1185652005596	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1185652005597	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1185652005598	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
1185652005599	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
1185652005600	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1185652005601	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1185652005602	Walker A/P-loop; other site
1185652005603	ATP binding site [chemical binding]; other site
1185652005604	Q-loop/lid; other site
1185652005605	ABC transporter signature motif; other site
1185652005606	Walker B; other site
1185652005607	D-loop; other site
1185652005608	H-loop/switch region; other site
1185652005609	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1185652005610	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1185652005611	active site
1185652005612	catalytic tetrad [active]
1185652005613	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1185652005614	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1185652005615	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1185652005616	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1185652005617	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
1185652005618	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1185652005619	transaminase, acetylornithine/succinylornithine family; Region: argD; TIGR00707
1185652005620	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1185652005621	catalytic residue [active]
1185652005622	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1185652005623	CoenzymeA binding site [chemical binding]; other site
1185652005624	subunit interaction site [polypeptide binding]; other site
1185652005625	PHB binding site; other site
1185652005626	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1185652005627	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1185652005628	Bacterial transcriptional regulator; Region: IclR; pfam01614
1185652005629	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1185652005630	FAD binding domain; Region: FAD_binding_4; pfam01565
1185652005631	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
1185652005632	tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812
1185652005633	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1185652005634	catalytic residue [active]
1185652005635	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1185652005636	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1185652005637	TM-ABC transporter signature motif; other site
1185652005638	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1185652005639	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1185652005640	TM-ABC transporter signature motif; other site
1185652005641	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1185652005642	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1185652005643	Walker A/P-loop; other site
1185652005644	ATP binding site [chemical binding]; other site
1185652005645	Q-loop/lid; other site
1185652005646	ABC transporter signature motif; other site
1185652005647	Walker B; other site
1185652005648	D-loop; other site
1185652005649	H-loop/switch region; other site
1185652005650	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1185652005651	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
1185652005652	ligand binding site [chemical binding]; other site
1185652005653	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1185652005654	classical (c) SDRs; Region: SDR_c; cd05233
1185652005655	NAD(P) binding site [chemical binding]; other site
1185652005656	active site
1185652005657	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1185652005658	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652005659	Walker A/P-loop; other site
1185652005660	ATP binding site [chemical binding]; other site
1185652005661	Q-loop/lid; other site
1185652005662	ABC transporter signature motif; other site
1185652005663	Walker B; other site
1185652005664	D-loop; other site
1185652005665	H-loop/switch region; other site
1185652005666	TOBE domain; Region: TOBE_2; pfam08402
1185652005667	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1185652005668	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1185652005669	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652005670	dimer interface [polypeptide binding]; other site
1185652005671	conserved gate region; other site
1185652005672	putative PBP binding loops; other site
1185652005673	ABC-ATPase subunit interface; other site
1185652005674	NIPSNAP; Region: NIPSNAP; pfam07978
1185652005675	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1185652005676	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1185652005677	TM-ABC transporter signature motif; other site
1185652005678	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652005679	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1185652005680	TM-ABC transporter signature motif; other site
1185652005681	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1185652005682	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1185652005683	Walker A/P-loop; other site
1185652005684	ATP binding site [chemical binding]; other site
1185652005685	Q-loop/lid; other site
1185652005686	ABC transporter signature motif; other site
1185652005687	Walker B; other site
1185652005688	D-loop; other site
1185652005689	H-loop/switch region; other site
1185652005690	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1185652005691	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1185652005692	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1185652005693	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1185652005694	Walker A/P-loop; other site
1185652005695	ATP binding site [chemical binding]; other site
1185652005696	Q-loop/lid; other site
1185652005697	ABC transporter signature motif; other site
1185652005698	Walker B; other site
1185652005699	D-loop; other site
1185652005700	H-loop/switch region; other site
1185652005701	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1185652005702	classical (c) SDRs; Region: SDR_c; cd05233
1185652005703	NAD(P) binding site [chemical binding]; other site
1185652005704	active site
1185652005705	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
1185652005706	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1185652005707	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1185652005708	metal binding site [ion binding]; metal-binding site
1185652005709	substrate binding pocket [chemical binding]; other site
1185652005710	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1185652005711	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
1185652005712	homodimer interface [polypeptide binding]; other site
1185652005713	substrate-cofactor binding pocket; other site
1185652005714	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652005715	catalytic residue [active]
1185652005716	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1185652005717	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652005718	DNA-binding site [nucleotide binding]; DNA binding site
1185652005719	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652005720	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652005721	homodimer interface [polypeptide binding]; other site
1185652005722	catalytic residue [active]
1185652005723	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652005724	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1185652005725	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652005726	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1185652005727	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1185652005728	active site
1185652005729	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1185652005730	dimer interface [polypeptide binding]; other site
1185652005731	substrate binding site [chemical binding]; other site
1185652005732	catalytic residues [active]
1185652005733	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1185652005734	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1185652005735	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1185652005736	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
1185652005737	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1185652005738	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1185652005739	active site
1185652005740	intersubunit interactions; other site
1185652005741	catalytic residue [active]
1185652005742	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1185652005743	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1185652005744	TPP-binding site [chemical binding]; other site
1185652005745	dimer interface [polypeptide binding]; other site
1185652005746	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1185652005747	PYR/PP interface [polypeptide binding]; other site
1185652005748	dimer interface [polypeptide binding]; other site
1185652005749	TPP binding site [chemical binding]; other site
1185652005750	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1185652005751	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1185652005752	triosephosphate isomerase; Provisional; Region: PRK14565
1185652005753	dimer interface [polypeptide binding]; other site
1185652005754	substrate binding site [chemical binding]; other site
1185652005755	catalytic triad [active]
1185652005756	short chain dehydrogenase; Provisional; Region: PRK06114
1185652005757	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652005758	NAD(P) binding site [chemical binding]; other site
1185652005759	active site
1185652005760	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1185652005761	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652005762	Walker A/P-loop; other site
1185652005763	ATP binding site [chemical binding]; other site
1185652005764	Q-loop/lid; other site
1185652005765	ABC transporter signature motif; other site
1185652005766	Walker B; other site
1185652005767	D-loop; other site
1185652005768	H-loop/switch region; other site
1185652005769	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652005770	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1185652005771	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1185652005772	ligand binding site [chemical binding]; other site
1185652005773	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652005774	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652005775	TM-ABC transporter signature motif; other site
1185652005776	transketolase; Reviewed; Region: PRK05899
1185652005777	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1185652005778	TPP-binding site [chemical binding]; other site
1185652005779	dimer interface [polypeptide binding]; other site
1185652005780	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1185652005781	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1185652005782	PYR/PP interface [polypeptide binding]; other site
1185652005783	dimer interface [polypeptide binding]; other site
1185652005784	TPP binding site [chemical binding]; other site
1185652005785	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1185652005786	bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791
1185652005787	N- and C-terminal domain interface [polypeptide binding]; other site
1185652005788	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
1185652005789	active site
1185652005790	MgATP binding site [chemical binding]; other site
1185652005791	catalytic site [active]
1185652005792	metal binding site [ion binding]; metal-binding site
1185652005793	putative homotetramer interface [polypeptide binding]; other site
1185652005794	putative homodimer interface [polypeptide binding]; other site
1185652005795	glycerol binding site [chemical binding]; other site
1185652005796	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1185652005797	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1185652005798	DNA binding residues [nucleotide binding]
1185652005799	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1185652005800	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1185652005801	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652005802	NAD(P) binding site [chemical binding]; other site
1185652005803	active site
1185652005804	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1185652005805	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1185652005806	substrate binding site [chemical binding]; other site
1185652005807	dimer interface [polypeptide binding]; other site
1185652005808	ATP binding site [chemical binding]; other site
1185652005809	DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337
1185652005810	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1185652005811	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1185652005812	putative active site [active]
1185652005813	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652005814	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652005815	TM-ABC transporter signature motif; other site
1185652005816	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1185652005817	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652005818	Walker A/P-loop; other site
1185652005819	ATP binding site [chemical binding]; other site
1185652005820	Q-loop/lid; other site
1185652005821	ABC transporter signature motif; other site
1185652005822	Walker B; other site
1185652005823	D-loop; other site
1185652005824	H-loop/switch region; other site
1185652005825	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652005826	Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320
1185652005827	D-allose transporter subunit; Provisional; Region: PRK09701
1185652005828	ligand binding site [chemical binding]; other site
1185652005829	dimerization interface [polypeptide binding]; other site
1185652005830	zinc binding site [ion binding]; other site
1185652005831	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
1185652005832	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1185652005833	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652005834	active site
1185652005835	dihydroxyacetone kinase; Provisional; Region: PRK14479
1185652005836	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
1185652005837	DAK2 domain; Region: Dak2; pfam02734
1185652005838	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1185652005839	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652005840	Walker A/P-loop; other site
1185652005841	ATP binding site [chemical binding]; other site
1185652005842	Q-loop/lid; other site
1185652005843	ABC transporter signature motif; other site
1185652005844	Walker B; other site
1185652005845	D-loop; other site
1185652005846	H-loop/switch region; other site
1185652005847	TOBE domain; Region: TOBE_2; pfam08402
1185652005848	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1185652005849	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1185652005850	nucleotide binding site [chemical binding]; other site
1185652005851	Class I aldolases; Region: Aldolase_Class_I; cl17187
1185652005852	catalytic residue [active]
1185652005853	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1185652005854	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1185652005855	NAD(P) binding site [chemical binding]; other site
1185652005856	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652005857	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652005858	dimer interface [polypeptide binding]; other site
1185652005859	conserved gate region; other site
1185652005860	putative PBP binding loops; other site
1185652005861	ABC-ATPase subunit interface; other site
1185652005862	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652005863	dimer interface [polypeptide binding]; other site
1185652005864	conserved gate region; other site
1185652005865	putative PBP binding loops; other site
1185652005866	ABC-ATPase subunit interface; other site
1185652005867	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652005868	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652005869	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1185652005870	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652005871	DNA-binding site [nucleotide binding]; DNA binding site
1185652005872	UTRA domain; Region: UTRA; pfam07702
1185652005873	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1185652005874	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1185652005875	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652005876	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1185652005877	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1185652005878	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1185652005879	E3 interaction surface; other site
1185652005880	lipoyl attachment site [posttranslational modification]; other site
1185652005881	e3 binding domain; Region: E3_binding; pfam02817
1185652005882	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1185652005883	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1185652005884	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1185652005885	alpha subunit interface [polypeptide binding]; other site
1185652005886	TPP binding site [chemical binding]; other site
1185652005887	heterodimer interface [polypeptide binding]; other site
1185652005888	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1185652005889	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1185652005890	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1185652005891	tetramer interface [polypeptide binding]; other site
1185652005892	TPP-binding site [chemical binding]; other site
1185652005893	heterodimer interface [polypeptide binding]; other site
1185652005894	phosphorylation loop region [posttranslational modification]
1185652005895	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
1185652005896	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1185652005897	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
1185652005898	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1185652005899	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1185652005900	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652005901	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652005902	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1185652005903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652005904	dimer interface [polypeptide binding]; other site
1185652005905	conserved gate region; other site
1185652005906	putative PBP binding loops; other site
1185652005907	ABC-ATPase subunit interface; other site
1185652005908	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652005909	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652005910	dimer interface [polypeptide binding]; other site
1185652005911	conserved gate region; other site
1185652005912	putative PBP binding loops; other site
1185652005913	ABC-ATPase subunit interface; other site
1185652005914	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1185652005915	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652005916	Walker A/P-loop; other site
1185652005917	ATP binding site [chemical binding]; other site
1185652005918	Q-loop/lid; other site
1185652005919	ABC transporter signature motif; other site
1185652005920	Walker B; other site
1185652005921	D-loop; other site
1185652005922	H-loop/switch region; other site
1185652005923	TOBE domain; Region: TOBE_2; pfam08402
1185652005924	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1185652005925	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1185652005926	substrate binding site [chemical binding]; other site
1185652005927	ATP binding site [chemical binding]; other site
1185652005928	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1185652005929	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
1185652005930	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1185652005931	putative NAD(P) binding site [chemical binding]; other site
1185652005932	catalytic Zn binding site [ion binding]; other site
1185652005933	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1185652005934	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1185652005935	ligand binding site [chemical binding]; other site
1185652005936	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1185652005937	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652005938	Walker A/P-loop; other site
1185652005939	ATP binding site [chemical binding]; other site
1185652005940	Q-loop/lid; other site
1185652005941	ABC transporter signature motif; other site
1185652005942	Walker B; other site
1185652005943	D-loop; other site
1185652005944	H-loop/switch region; other site
1185652005945	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652005946	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652005947	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652005948	TM-ABC transporter signature motif; other site
1185652005949	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1185652005950	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1185652005951	DNA binding residues [nucleotide binding]
1185652005952	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1185652005953	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1185652005954	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1185652005955	substrate binding site [chemical binding]; other site
1185652005956	ATP binding site [chemical binding]; other site
1185652005957	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1185652005958	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1185652005959	MULE transposase domain; Region: MULE; pfam10551
1185652005960	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1185652005961	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652005962	DNA-binding site [nucleotide binding]; DNA binding site
1185652005963	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652005964	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652005965	homodimer interface [polypeptide binding]; other site
1185652005966	catalytic residue [active]
1185652005967	Cupin domain; Region: Cupin_2; pfam07883
1185652005968	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1185652005969	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1185652005970	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652005971	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652005972	NAD(P) binding site [chemical binding]; other site
1185652005973	active site
1185652005974	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
1185652005975	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1185652005976	tetramer interface [polypeptide binding]; other site
1185652005977	TPP-binding site [chemical binding]; other site
1185652005978	heterodimer interface [polypeptide binding]; other site
1185652005979	phosphorylation loop region [posttranslational modification]
1185652005980	putative transcriptional regulator; Provisional; Region: PRK11640
1185652005981	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652005982	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
1185652005983	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1185652005984	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1185652005985	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652005986	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652005987	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652005988	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1185652005989	dimerization interface [polypeptide binding]; other site
1185652005990	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1185652005991	SelR domain; Region: SelR; pfam01641
1185652005992	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1185652005993	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1185652005994	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
1185652005995	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652005996	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652005997	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
1185652005998	putative effector binding pocket; other site
1185652005999	putative dimerization interface [polypeptide binding]; other site
1185652006000	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
1185652006001	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1185652006002	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652006003	substrate binding pocket [chemical binding]; other site
1185652006004	membrane-bound complex binding site; other site
1185652006005	hinge residues; other site
1185652006006	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
1185652006007	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652006008	Walker A/P-loop; other site
1185652006009	ATP binding site [chemical binding]; other site
1185652006010	Q-loop/lid; other site
1185652006011	ABC transporter signature motif; other site
1185652006012	Walker B; other site
1185652006013	D-loop; other site
1185652006014	H-loop/switch region; other site
1185652006015	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652006016	dimer interface [polypeptide binding]; other site
1185652006017	conserved gate region; other site
1185652006018	putative PBP binding loops; other site
1185652006019	ABC-ATPase subunit interface; other site
1185652006020	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1185652006021	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652006022	dimer interface [polypeptide binding]; other site
1185652006023	conserved gate region; other site
1185652006024	putative PBP binding loops; other site
1185652006025	ABC-ATPase subunit interface; other site
1185652006026	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652006027	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1185652006028	substrate binding pocket [chemical binding]; other site
1185652006029	membrane-bound complex binding site; other site
1185652006030	hinge residues; other site
1185652006031	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
1185652006032	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
1185652006033	Peptidase family M28; Region: Peptidase_M28; pfam04389
1185652006034	metal binding site [ion binding]; metal-binding site
1185652006035	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
1185652006036	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1185652006037	putative metal binding site [ion binding]; other site
1185652006038	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1185652006039	FCD domain; Region: FCD; pfam07729
1185652006040	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1185652006041	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1185652006042	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1185652006043	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
1185652006044	Protein of unknown function (DUF736); Region: DUF736; cl02303
1185652006045	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
1185652006046	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
1185652006047	CsbD-like; Region: CsbD; cl17424
1185652006048	Integrase core domain; Region: rve_3; cl15866
1185652006049	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1185652006050	PRC-barrel domain; Region: PRC; pfam05239
1185652006051	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
1185652006052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652006053	active site
1185652006054	phosphorylation site [posttranslational modification]
1185652006055	intermolecular recognition site; other site
1185652006056	dimerization interface [polypeptide binding]; other site
1185652006057	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1185652006058	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1185652006059	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
1185652006060	oligomer interface [polypeptide binding]; other site
1185652006061	metal binding site [ion binding]; metal-binding site
1185652006062	metal binding site [ion binding]; metal-binding site
1185652006063	putative Cl binding site [ion binding]; other site
1185652006064	basic sphincter; other site
1185652006065	hydrophobic gate; other site
1185652006066	periplasmic entrance; other site
1185652006067	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
1185652006068	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1185652006069	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652006070	active site
1185652006071	phosphorylation site [posttranslational modification]
1185652006072	intermolecular recognition site; other site
1185652006073	dimerization interface [polypeptide binding]; other site
1185652006074	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652006075	PAS domain; Region: PAS_9; pfam13426
1185652006076	putative active site [active]
1185652006077	heme pocket [chemical binding]; other site
1185652006078	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1185652006079	HWE histidine kinase; Region: HWE_HK; smart00911
1185652006080	PRC-barrel domain; Region: PRC; pfam05239
1185652006081	PAS domain; Region: PAS_9; pfam13426
1185652006082	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1185652006083	Histidine kinase; Region: HisKA_2; pfam07568
1185652006084	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
1185652006085	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652006086	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1185652006087	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1185652006088	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
1185652006089	active site
1185652006090	nucleophile elbow; other site
1185652006091	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
1185652006092	dimerization interface [polypeptide binding]; other site
1185652006093	metal binding site [ion binding]; metal-binding site
1185652006094	Integrase core domain; Region: rve; pfam00665
1185652006095	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
1185652006096	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1185652006097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652006098	active site
1185652006099	phosphorylation site [posttranslational modification]
1185652006100	intermolecular recognition site; other site
1185652006101	dimerization interface [polypeptide binding]; other site
1185652006102	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652006103	PAS domain; Region: PAS_9; pfam13426
1185652006104	putative active site [active]
1185652006105	heme pocket [chemical binding]; other site
1185652006106	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1185652006107	HWE histidine kinase; Region: HWE_HK; smart00911
1185652006108	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
1185652006109	putative metal binding residues [ion binding]; other site
1185652006110	CHAD domain; Region: CHAD; pfam05235
1185652006111	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1185652006112	DoxX-like family; Region: DoxX_2; pfam13564
1185652006113	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1185652006114	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652006115	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652006116	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1185652006117	dimerization interface [polypeptide binding]; other site
1185652006118	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1185652006119	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1185652006120	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1185652006121	inhibitor site; inhibition site
1185652006122	active site
1185652006123	dimer interface [polypeptide binding]; other site
1185652006124	catalytic residue [active]
1185652006125	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
1185652006126	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1185652006127	homodimer interface [polypeptide binding]; other site
1185652006128	substrate-cofactor binding pocket; other site
1185652006129	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652006130	catalytic residue [active]
1185652006131	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652006132	DNA-binding site [nucleotide binding]; DNA binding site
1185652006133	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1185652006134	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652006135	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652006136	homodimer interface [polypeptide binding]; other site
1185652006137	catalytic residue [active]
1185652006138	MOSC domain; Region: MOSC; pfam03473
1185652006139	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1185652006140	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1185652006141	FMN-binding pocket [chemical binding]; other site
1185652006142	flavin binding motif; other site
1185652006143	phosphate binding motif [ion binding]; other site
1185652006144	beta-alpha-beta structure motif; other site
1185652006145	NAD binding pocket [chemical binding]; other site
1185652006146	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1185652006147	catalytic loop [active]
1185652006148	iron binding site [ion binding]; other site
1185652006149	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652006150	cyclase homology domain; Region: CHD; cd07302
1185652006151	nucleotidyl binding site; other site
1185652006152	metal binding site [ion binding]; metal-binding site
1185652006153	dimer interface [polypeptide binding]; other site
1185652006154	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
1185652006155	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
1185652006156	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
1185652006157	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
1185652006158	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
1185652006159	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1185652006160	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1185652006161	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652006162	active site
1185652006163	phosphorylation site [posttranslational modification]
1185652006164	intermolecular recognition site; other site
1185652006165	dimerization interface [polypeptide binding]; other site
1185652006166	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652006167	DNA binding site [nucleotide binding]
1185652006168	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1185652006169	HAMP domain; Region: HAMP; pfam00672
1185652006170	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652006171	dimer interface [polypeptide binding]; other site
1185652006172	phosphorylation site [posttranslational modification]
1185652006173	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652006174	ATP binding site [chemical binding]; other site
1185652006175	Mg2+ binding site [ion binding]; other site
1185652006176	G-X-G motif; other site
1185652006177	Putative phosphatase (DUF442); Region: DUF442; cl17385
1185652006178	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1185652006179	Transposase; Region: HTH_Tnp_1; pfam01527
1185652006180	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652006181	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1185652006182	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1185652006183	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652006184	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1185652006185	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652006186	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1185652006187	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1185652006188	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1185652006189	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652006190	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652006191	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652006192	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652006193	TM-ABC transporter signature motif; other site
1185652006194	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1185652006195	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652006196	Walker A/P-loop; other site
1185652006197	ATP binding site [chemical binding]; other site
1185652006198	Q-loop/lid; other site
1185652006199	ABC transporter signature motif; other site
1185652006200	Walker B; other site
1185652006201	D-loop; other site
1185652006202	H-loop/switch region; other site
1185652006203	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652006204	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652006205	TM-ABC transporter signature motif; other site
1185652006206	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1185652006207	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1185652006208	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652006209	DNA binding site [nucleotide binding]
1185652006210	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1185652006211	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1185652006212	putative acyltransferase; Provisional; Region: PRK05790
1185652006213	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1185652006214	dimer interface [polypeptide binding]; other site
1185652006215	active site
1185652006216	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1185652006217	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1185652006218	FMN binding site [chemical binding]; other site
1185652006219	active site
1185652006220	substrate binding site [chemical binding]; other site
1185652006221	catalytic residue [active]
1185652006222	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1185652006223	classical (c) SDRs; Region: SDR_c; cd05233
1185652006224	NAD(P) binding site [chemical binding]; other site
1185652006225	active site
1185652006226	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1185652006227	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652006228	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1185652006229	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1185652006230	putative NAD(P) binding site [chemical binding]; other site
1185652006231	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652006232	cyclase homology domain; Region: CHD; cd07302
1185652006233	nucleotidyl binding site; other site
1185652006234	metal binding site [ion binding]; metal-binding site
1185652006235	dimer interface [polypeptide binding]; other site
1185652006236	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
1185652006237	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1185652006238	dimer interface [polypeptide binding]; other site
1185652006239	active site
1185652006240	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1185652006241	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1185652006242	putative membrane fusion protein; Region: TIGR02828
1185652006243	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1185652006244	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1185652006245	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652006246	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1185652006247	putative C-terminal domain interface [polypeptide binding]; other site
1185652006248	putative GSH binding site (G-site) [chemical binding]; other site
1185652006249	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1185652006250	putative dimer interface [polypeptide binding]; other site
1185652006251	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
1185652006252	N-terminal domain interface [polypeptide binding]; other site
1185652006253	putative substrate binding pocket (H-site) [chemical binding]; other site
1185652006254	dimer interface [polypeptide binding]; other site
1185652006255	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1185652006256	Walker A motif; other site
1185652006257	ATP binding site [chemical binding]; other site
1185652006258	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652006259	Transcriptional regulator; Region: Rrf2; pfam02082
1185652006260	Rrf2 family protein; Region: rrf2_super; TIGR00738
1185652006261	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1185652006262	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1185652006263	active site 1 [active]
1185652006264	dimer interface [polypeptide binding]; other site
1185652006265	hexamer interface [polypeptide binding]; other site
1185652006266	active site 2 [active]
1185652006267	short chain dehydrogenase; Provisional; Region: PRK12937
1185652006268	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
1185652006269	NADP binding site [chemical binding]; other site
1185652006270	homodimer interface [polypeptide binding]; other site
1185652006271	active site
1185652006272	substrate binding site [chemical binding]; other site
1185652006273	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652006274	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652006275	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1185652006276	putative effector binding pocket; other site
1185652006277	putative dimerization interface [polypeptide binding]; other site
1185652006278	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
1185652006279	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652006280	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1185652006281	dimer interface [polypeptide binding]; other site
1185652006282	phosphorylation site [posttranslational modification]
1185652006283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652006284	ATP binding site [chemical binding]; other site
1185652006285	Mg2+ binding site [ion binding]; other site
1185652006286	G-X-G motif; other site
1185652006287	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652006288	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652006289	active site
1185652006290	phosphorylation site [posttranslational modification]
1185652006291	intermolecular recognition site; other site
1185652006292	dimerization interface [polypeptide binding]; other site
1185652006293	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652006294	DNA binding site [nucleotide binding]
1185652006295	Cupin; Region: Cupin_6; pfam12852
1185652006296	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652006297	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1185652006298	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652006299	Cupin; Region: Cupin_6; pfam12852
1185652006300	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1185652006301	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1185652006302	putative NAD(P) binding site [chemical binding]; other site
1185652006303	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1185652006304	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
1185652006305	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1185652006306	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
1185652006307	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652006308	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1185652006309	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177
1185652006310	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652006311	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1185652006312	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652006313	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1185652006314	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1185652006315	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1185652006316	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1185652006317	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1185652006318	NAD binding site [chemical binding]; other site
1185652006319	catalytic residues [active]
1185652006320	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1185652006321	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914
1185652006322	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1185652006323	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1185652006324	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1185652006325	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652006326	dimerization interface [polypeptide binding]; other site
1185652006327	putative DNA binding site [nucleotide binding]; other site
1185652006328	putative Zn2+ binding site [ion binding]; other site
1185652006329	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652006330	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
1185652006331	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1185652006332	putative active site [active]
1185652006333	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1185652006334	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1185652006335	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
1185652006336	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
1185652006337	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
1185652006338	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
1185652006339	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1185652006340	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652006341	active site
1185652006342	phosphorylation site [posttranslational modification]
1185652006343	intermolecular recognition site; other site
1185652006344	dimerization interface [polypeptide binding]; other site
1185652006345	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652006346	DNA binding site [nucleotide binding]
1185652006347	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1185652006348	Putative phosphatase (DUF442); Region: DUF442; cl17385
1185652006349	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
1185652006350	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
1185652006351	active site clefts [active]
1185652006352	zinc binding site [ion binding]; other site
1185652006353	dimer interface [polypeptide binding]; other site
1185652006354	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1185652006355	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652006356	motif II; other site
1185652006357	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1185652006358	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1185652006359	catalytic residue [active]
1185652006360	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1185652006361	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1185652006362	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1185652006363	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1185652006364	Transposase; Region: HTH_Tnp_1; pfam01527
1185652006365	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652006366	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1185652006367	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1185652006368	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652006369	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1185652006370	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652006371	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1185652006372	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
1185652006373	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
1185652006374	active site
1185652006375	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
1185652006376	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
1185652006377	ThiF family; Region: ThiF; pfam00899
1185652006378	ATP binding site [chemical binding]; other site
1185652006379	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
1185652006380	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
1185652006381	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
1185652006382	Prokaryotic E2 family E; Region: Prok-E2_E; pfam14462
1185652006383	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1185652006384	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652006385	non-specific DNA binding site [nucleotide binding]; other site
1185652006386	salt bridge; other site
1185652006387	sequence-specific DNA binding site [nucleotide binding]; other site
1185652006388	Protein of unknown function (DUF904); Region: DUF904; pfam06005
1185652006389	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652006390	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423
1185652006391	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
1185652006392	putative active site [active]
1185652006393	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1185652006394	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1185652006395	active site
1185652006396	DNA binding site [nucleotide binding]
1185652006397	Int/Topo IB signature motif; other site
1185652006398	Uncharacterized conserved protein [Function unknown]; Region: COG5654
1185652006399	Uncharacterized conserved protein [Function unknown]; Region: COG5642
1185652006400	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
1185652006401	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1185652006402	active site
1185652006403	NTP binding site [chemical binding]; other site
1185652006404	metal binding triad [ion binding]; metal-binding site
1185652006405	antibiotic binding site [chemical binding]; other site
1185652006406	Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748
1185652006407	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1185652006408	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1185652006409	Walker A/P-loop; other site
1185652006410	ATP binding site [chemical binding]; other site
1185652006411	Q-loop/lid; other site
1185652006412	ABC transporter signature motif; other site
1185652006413	Walker B; other site
1185652006414	D-loop; other site
1185652006415	H-loop/switch region; other site
1185652006416	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652006417	dimer interface [polypeptide binding]; other site
1185652006418	conserved gate region; other site
1185652006419	putative PBP binding loops; other site
1185652006420	ABC-ATPase subunit interface; other site
1185652006421	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1185652006422	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652006423	dimer interface [polypeptide binding]; other site
1185652006424	conserved gate region; other site
1185652006425	ABC-ATPase subunit interface; other site
1185652006426	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652006427	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1185652006428	substrate binding pocket [chemical binding]; other site
1185652006429	membrane-bound complex binding site; other site
1185652006430	hinge residues; other site
1185652006431	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652006432	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652006433	DNA binding site [nucleotide binding]
1185652006434	domain linker motif; other site
1185652006435	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1185652006436	putative dimerization interface [polypeptide binding]; other site
1185652006437	putative ligand binding site [chemical binding]; other site
1185652006438	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315
1185652006439	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1185652006440	putative ligand binding site [chemical binding]; other site
1185652006441	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652006442	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652006443	TM-ABC transporter signature motif; other site
1185652006444	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1185652006445	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652006446	Walker A/P-loop; other site
1185652006447	ATP binding site [chemical binding]; other site
1185652006448	Q-loop/lid; other site
1185652006449	ABC transporter signature motif; other site
1185652006450	Walker B; other site
1185652006451	D-loop; other site
1185652006452	H-loop/switch region; other site
1185652006453	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652006454	BON domain; Region: BON; pfam04972
1185652006455	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
1185652006456	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1185652006457	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
1185652006458	putative NAD(P) binding site [chemical binding]; other site
1185652006459	putative active site [active]
1185652006460	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1185652006461	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652006462	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1185652006463	dimerization interface [polypeptide binding]; other site
1185652006464	substrate binding pocket [chemical binding]; other site
1185652006465	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1185652006466	dimerization interface [polypeptide binding]; other site
1185652006467	PAS domain; Region: PAS_9; pfam13426
1185652006468	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652006469	putative active site [active]
1185652006470	heme pocket [chemical binding]; other site
1185652006471	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652006472	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652006473	metal binding site [ion binding]; metal-binding site
1185652006474	active site
1185652006475	I-site; other site
1185652006476	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1185652006477	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1185652006478	putative phosphoketolase; Provisional; Region: PRK05261
1185652006479	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
1185652006480	TPP-binding site; other site
1185652006481	XFP C-terminal domain; Region: XFP_C; pfam09363
1185652006482	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
1185652006483	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
1185652006484	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
1185652006485	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652006486	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652006487	NAD(P) binding site [chemical binding]; other site
1185652006488	active site
1185652006489	Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919
1185652006490	putative active site [active]
1185652006491	redox center [active]
1185652006492	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
1185652006493	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1185652006494	putative ADP-binding pocket [chemical binding]; other site
1185652006495	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1185652006496	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1185652006497	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1185652006498	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1185652006499	DctM-like transporters; Region: DctM; pfam06808
1185652006500	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1185652006501	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652006502	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652006503	DNA binding site [nucleotide binding]
1185652006504	domain linker motif; other site
1185652006505	This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273
1185652006506	putative ligand binding site [chemical binding]; other site
1185652006507	putative dimerization interface [polypeptide binding]; other site
1185652006508	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1185652006509	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1185652006510	HAMP domain; Region: HAMP; pfam00672
1185652006511	dimerization interface [polypeptide binding]; other site
1185652006512	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1185652006513	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1185652006514	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1185652006515	dimer interface [polypeptide binding]; other site
1185652006516	putative CheW interface [polypeptide binding]; other site
1185652006517	camphor resistance protein CrcB; Provisional; Region: PRK14198
1185652006518	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1185652006519	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1185652006520	dimerization interface [polypeptide binding]; other site
1185652006521	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1185652006522	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1185652006523	dimer interface [polypeptide binding]; other site
1185652006524	putative CheW interface [polypeptide binding]; other site
1185652006525	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652006526	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652006527	metal binding site [ion binding]; metal-binding site
1185652006528	active site
1185652006529	I-site; other site
1185652006530	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1185652006531	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652006532	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652006533	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652006534	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
1185652006535	putative dimerization interface [polypeptide binding]; other site
1185652006536	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1185652006537	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
1185652006538	ligand binding site [chemical binding]; other site
1185652006539	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652006540	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1185652006541	TM-ABC transporter signature motif; other site
1185652006542	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1185652006543	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1185652006544	TM-ABC transporter signature motif; other site
1185652006545	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1185652006546	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1185652006547	Walker A/P-loop; other site
1185652006548	ATP binding site [chemical binding]; other site
1185652006549	Q-loop/lid; other site
1185652006550	ABC transporter signature motif; other site
1185652006551	Walker B; other site
1185652006552	D-loop; other site
1185652006553	H-loop/switch region; other site
1185652006554	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1185652006555	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1185652006556	Walker A/P-loop; other site
1185652006557	ATP binding site [chemical binding]; other site
1185652006558	Q-loop/lid; other site
1185652006559	ABC transporter signature motif; other site
1185652006560	Walker B; other site
1185652006561	D-loop; other site
1185652006562	H-loop/switch region; other site
1185652006563	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
1185652006564	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1185652006565	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1185652006566	shikimate binding site; other site
1185652006567	NAD(P) binding site [chemical binding]; other site
1185652006568	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1185652006569	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
1185652006570	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1185652006571	dimer interface [polypeptide binding]; other site
1185652006572	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1185652006573	active site
1185652006574	Fe binding site [ion binding]; other site
1185652006575	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652006576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652006577	active site
1185652006578	phosphorylation site [posttranslational modification]
1185652006579	intermolecular recognition site; other site
1185652006580	dimerization interface [polypeptide binding]; other site
1185652006581	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652006582	dimerization interface [polypeptide binding]; other site
1185652006583	DNA binding residues [nucleotide binding]
1185652006584	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
1185652006585	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1185652006586	Na binding site [ion binding]; other site
1185652006587	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1185652006588	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652006589	putative active site [active]
1185652006590	heme pocket [chemical binding]; other site
1185652006591	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652006592	dimer interface [polypeptide binding]; other site
1185652006593	phosphorylation site [posttranslational modification]
1185652006594	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652006595	ATP binding site [chemical binding]; other site
1185652006596	Mg2+ binding site [ion binding]; other site
1185652006597	G-X-G motif; other site
1185652006598	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1185652006599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652006600	active site
1185652006601	phosphorylation site [posttranslational modification]
1185652006602	intermolecular recognition site; other site
1185652006603	dimerization interface [polypeptide binding]; other site
1185652006604	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1185652006605	Na binding site [ion binding]; other site
1185652006606	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
1185652006607	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1185652006608	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1185652006609	type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404
1185652006610	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
1185652006611	TPR repeat; Region: TPR_11; pfam13414
1185652006612	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652006613	TPR motif; other site
1185652006614	binding surface
1185652006615	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
1185652006616	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
1185652006617	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
1185652006618	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1185652006619	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
1185652006620	FHIPEP family; Region: FHIPEP; pfam00771
1185652006621	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
1185652006622	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
1185652006623	phosphopeptide binding site; other site
1185652006624	type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516
1185652006625	type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544
1185652006626	type III secretion system protein; Reviewed; Region: PRK06937
1185652006627	Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157
1185652006628	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1185652006629	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1185652006630	Walker A motif; other site
1185652006631	ATP binding site [chemical binding]; other site
1185652006632	Walker B motif; other site
1185652006633	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
1185652006634	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
1185652006635	type III secretion system protein YscR; Provisional; Region: PRK12797
1185652006636	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
1185652006637	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
1185652006638	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1185652006639	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1185652006640	Protein of unknown function (DUF2000); Region: DUF2000; pfam09391
1185652006641	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1185652006642	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1185652006643	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652006644	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1185652006645	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652006646	SPW repeat; Region: SPW; pfam03779
1185652006647	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652006648	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652006649	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1185652006650	Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813
1185652006651	conserved cys residue [active]
1185652006652	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1185652006653	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652006654	Walker A/P-loop; other site
1185652006655	ATP binding site [chemical binding]; other site
1185652006656	Q-loop/lid; other site
1185652006657	ABC transporter signature motif; other site
1185652006658	Walker B; other site
1185652006659	D-loop; other site
1185652006660	H-loop/switch region; other site
1185652006661	TOBE domain; Region: TOBE_2; pfam08402
1185652006662	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652006663	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652006664	dimer interface [polypeptide binding]; other site
1185652006665	conserved gate region; other site
1185652006666	putative PBP binding loops; other site
1185652006667	ABC-ATPase subunit interface; other site
1185652006668	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652006669	dimer interface [polypeptide binding]; other site
1185652006670	conserved gate region; other site
1185652006671	putative PBP binding loops; other site
1185652006672	ABC-ATPase subunit interface; other site
1185652006673	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652006674	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1185652006675	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652006676	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652006677	DNA binding site [nucleotide binding]
1185652006678	domain linker motif; other site
1185652006679	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
1185652006680	ligand binding site [chemical binding]; other site
1185652006681	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1185652006682	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
1185652006683	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1185652006684	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652006685	putative substrate translocation pore; other site
1185652006686	Dodecin; Region: Dodecin; pfam07311
1185652006687	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1185652006688	peptidase T; Region: peptidase-T; TIGR01882
1185652006689	metal binding site [ion binding]; metal-binding site
1185652006690	dimer interface [polypeptide binding]; other site
1185652006691	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1185652006692	homotrimer interaction site [polypeptide binding]; other site
1185652006693	putative active site [active]
1185652006694	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1185652006695	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652006696	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1185652006697	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1185652006698	elongation factor G; Reviewed; Region: PRK12740
1185652006699	G1 box; other site
1185652006700	GTP/Mg2+ binding site [chemical binding]; other site
1185652006701	Switch I region; other site
1185652006702	G3 box; other site
1185652006703	Switch II region; other site
1185652006704	G4 box; other site
1185652006705	G5 box; other site
1185652006706	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1185652006707	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1185652006708	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652006709	DNA-binding site [nucleotide binding]; DNA binding site
1185652006710	UTRA domain; Region: UTRA; pfam07702
1185652006711	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
1185652006712	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1185652006713	P-loop; other site
1185652006714	Magnesium ion binding site [ion binding]; other site
1185652006715	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1185652006716	Magnesium ion binding site [ion binding]; other site
1185652006717	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
1185652006718	ParB-like nuclease domain; Region: ParB; smart00470
1185652006719	replication initiation protein RepC; Provisional; Region: PRK13824
1185652006720	Replication protein C N-terminal domain; Region: RP-C; pfam03428
1185652006721	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
1185652006722	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
1185652006723	HTH DNA binding domain; Region: HTH_13; pfam11972
1185652006724	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1185652006725	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1185652006726	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652006727	DNA-binding site [nucleotide binding]; DNA binding site
1185652006728	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652006729	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652006730	homodimer interface [polypeptide binding]; other site
1185652006731	catalytic residue [active]
1185652006732	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1185652006733	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1185652006734	BCCT family transporter; Region: BCCT; pfam02028
1185652006735	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1185652006736	CoA binding domain; Region: CoA_binding; smart00881
1185652006737	CoA-ligase; Region: Ligase_CoA; pfam00549
1185652006738	malate--CoA ligase subunit beta; Provisional; Region: PRK14046
1185652006739	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1185652006740	CoA-ligase; Region: Ligase_CoA; pfam00549
1185652006741	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1185652006742	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
1185652006743	homodimer interface [polypeptide binding]; other site
1185652006744	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652006745	catalytic residue [active]
1185652006746	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652006747	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652006748	DNA binding residues [nucleotide binding]
1185652006749	dimerization interface [polypeptide binding]; other site
1185652006750	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1185652006751	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
1185652006752	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652006753	S-adenosylmethionine binding site [chemical binding]; other site
1185652006754	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652006755	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652006756	DNA binding site [nucleotide binding]
1185652006757	domain linker motif; other site
1185652006758	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
1185652006759	putative dimerization interface [polypeptide binding]; other site
1185652006760	putative ligand binding site [chemical binding]; other site
1185652006761	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1185652006762	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1185652006763	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1185652006764	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652006765	dimer interface [polypeptide binding]; other site
1185652006766	conserved gate region; other site
1185652006767	putative PBP binding loops; other site
1185652006768	ABC-ATPase subunit interface; other site
1185652006769	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652006770	dimer interface [polypeptide binding]; other site
1185652006771	conserved gate region; other site
1185652006772	putative PBP binding loops; other site
1185652006773	ABC-ATPase subunit interface; other site
1185652006774	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1185652006775	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652006776	Walker A/P-loop; other site
1185652006777	ATP binding site [chemical binding]; other site
1185652006778	Q-loop/lid; other site
1185652006779	ABC transporter signature motif; other site
1185652006780	Walker B; other site
1185652006781	D-loop; other site
1185652006782	H-loop/switch region; other site
1185652006783	TOBE domain; Region: TOBE_2; pfam08402
1185652006784	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1185652006785	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
1185652006786	active site
1185652006787	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652006788	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1185652006789	substrate binding pocket [chemical binding]; other site
1185652006790	membrane-bound complex binding site; other site
1185652006791	hinge residues; other site
1185652006792	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1185652006793	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652006794	Walker A/P-loop; other site
1185652006795	ATP binding site [chemical binding]; other site
1185652006796	Q-loop/lid; other site
1185652006797	ABC transporter signature motif; other site
1185652006798	Walker B; other site
1185652006799	D-loop; other site
1185652006800	H-loop/switch region; other site
1185652006801	TOBE domain; Region: TOBE_2; pfam08402
1185652006802	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652006803	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652006804	dimer interface [polypeptide binding]; other site
1185652006805	conserved gate region; other site
1185652006806	ABC-ATPase subunit interface; other site
1185652006807	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1185652006808	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652006809	putative PBP binding loops; other site
1185652006810	dimer interface [polypeptide binding]; other site
1185652006811	ABC-ATPase subunit interface; other site
1185652006812	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652006813	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1185652006814	RibD C-terminal domain; Region: RibD_C; cl17279
1185652006815	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1185652006816	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
1185652006817	ligand binding site; other site
1185652006818	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
1185652006819	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1185652006820	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
1185652006821	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1185652006822	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1185652006823	active site
1185652006824	Fe binding site [ion binding]; other site
1185652006825	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
1185652006826	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1185652006827	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1185652006828	shikimate binding site; other site
1185652006829	NAD(P) binding site [chemical binding]; other site
1185652006830	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1185652006831	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1185652006832	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1185652006833	DctM-like transporters; Region: DctM; pfam06808
1185652006834	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1185652006835	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
1185652006836	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652006837	replicative DNA helicase; Provisional; Region: PRK05973
1185652006838	Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305
1185652006839	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1185652006840	active site
1185652006841	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
1185652006842	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1185652006843	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652006844	putative substrate translocation pore; other site
1185652006845	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652006846	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1185652006847	putative DNA binding site [nucleotide binding]; other site
1185652006848	putative Zn2+ binding site [ion binding]; other site
1185652006849	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652006850	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1185652006851	oligomeric interface; other site
1185652006852	putative active site [active]
1185652006853	homodimer interface [polypeptide binding]; other site
1185652006854	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
1185652006855	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
1185652006856	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1185652006857	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1185652006858	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1185652006859	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1185652006860	RNA binding surface [nucleotide binding]; other site
1185652006861	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1185652006862	active site
1185652006863	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
1185652006864	MarR family; Region: MarR_2; cl17246
1185652006865	5-oxoprolinase; Region: PLN02666
1185652006866	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1185652006867	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1185652006868	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1185652006869	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
1185652006870	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1185652006871	oligomeric interface; other site
1185652006872	putative active site [active]
1185652006873	homodimer interface [polypeptide binding]; other site
1185652006874	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1185652006875	active site
1185652006876	metal binding site [ion binding]; metal-binding site
1185652006877	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652006878	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652006879	cyclase homology domain; Region: CHD; cd07302
1185652006880	nucleotidyl binding site; other site
1185652006881	metal binding site [ion binding]; metal-binding site
1185652006882	dimer interface [polypeptide binding]; other site
1185652006883	Predicted integral membrane protein [Function unknown]; Region: COG5616
1185652006884	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652006885	TPR motif; other site
1185652006886	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1185652006887	binding surface
1185652006888	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1185652006889	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1185652006890	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1185652006891	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1185652006892	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
1185652006893	aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433
1185652006894	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1185652006895	catalytic loop [active]
1185652006896	iron binding site [ion binding]; other site
1185652006897	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1185652006898	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1185652006899	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652006900	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
1185652006901	Isochorismatase family; Region: Isochorismatase; pfam00857
1185652006902	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1185652006903	catalytic triad [active]
1185652006904	conserved cis-peptide bond; other site
1185652006905	DinB family; Region: DinB; cl17821
1185652006906	DinB superfamily; Region: DinB_2; pfam12867
1185652006907	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1185652006908	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
1185652006909	conserved cys residue [active]
1185652006910	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
1185652006911	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652006912	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1185652006913	Methyltransferase domain; Region: Methyltransf_18; pfam12847
1185652006914	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1185652006915	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1185652006916	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1185652006917	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1185652006918	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1185652006919	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1185652006920	ABC-ATPase subunit  interface; other site
1185652006921	dimer interface [polypeptide binding]; other site
1185652006922	putative PBP binding regions; other site
1185652006923	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1185652006924	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1185652006925	Walker A/P-loop; other site
1185652006926	ATP binding site [chemical binding]; other site
1185652006927	Q-loop/lid; other site
1185652006928	ABC transporter signature motif; other site
1185652006929	Walker B; other site
1185652006930	D-loop; other site
1185652006931	H-loop/switch region; other site
1185652006932	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
1185652006933	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
1185652006934	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
1185652006935	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1185652006936	putative ligand binding site [chemical binding]; other site
1185652006937	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1185652006938	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652006939	Walker A/P-loop; other site
1185652006940	ATP binding site [chemical binding]; other site
1185652006941	Q-loop/lid; other site
1185652006942	ABC transporter signature motif; other site
1185652006943	Walker B; other site
1185652006944	D-loop; other site
1185652006945	H-loop/switch region; other site
1185652006946	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652006947	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652006948	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652006949	TM-ABC transporter signature motif; other site
1185652006950	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652006951	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652006952	TM-ABC transporter signature motif; other site
1185652006953	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652006954	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652006955	DNA binding site [nucleotide binding]
1185652006956	domain linker motif; other site
1185652006957	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
1185652006958	dimerization interface [polypeptide binding]; other site
1185652006959	ligand binding site [chemical binding]; other site
1185652006960	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652006961	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652006962	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
1185652006963	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
1185652006964	NAD binding site [chemical binding]; other site
1185652006965	homodimer interface [polypeptide binding]; other site
1185652006966	homotetramer interface [polypeptide binding]; other site
1185652006967	active site
1185652006968	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1185652006969	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652006970	Walker A/P-loop; other site
1185652006971	ATP binding site [chemical binding]; other site
1185652006972	Q-loop/lid; other site
1185652006973	ABC transporter signature motif; other site
1185652006974	Walker B; other site
1185652006975	D-loop; other site
1185652006976	H-loop/switch region; other site
1185652006977	TOBE domain; Region: TOBE_2; pfam08402
1185652006978	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
1185652006979	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1185652006980	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1185652006981	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1185652006982	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652006983	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652006984	dimer interface [polypeptide binding]; other site
1185652006985	conserved gate region; other site
1185652006986	putative PBP binding loops; other site
1185652006987	ABC-ATPase subunit interface; other site
1185652006988	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652006989	dimer interface [polypeptide binding]; other site
1185652006990	putative PBP binding loops; other site
1185652006991	ABC-ATPase subunit interface; other site
1185652006992	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652006993	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652006994	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
1185652006995	putative active site [active]
1185652006996	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
1185652006997	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652006998	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
1185652006999	putative dimerization interface [polypeptide binding]; other site
1185652007000	putative ligand binding site [chemical binding]; other site
1185652007001	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1185652007002	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1185652007003	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652007004	alpha-galactosidase; Provisional; Region: PRK15076
1185652007005	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
1185652007006	NAD binding site [chemical binding]; other site
1185652007007	sugar binding site [chemical binding]; other site
1185652007008	divalent metal binding site [ion binding]; other site
1185652007009	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1185652007010	dimer interface [polypeptide binding]; other site
1185652007011	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
1185652007012	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1185652007013	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1185652007014	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652007015	dimer interface [polypeptide binding]; other site
1185652007016	conserved gate region; other site
1185652007017	putative PBP binding loops; other site
1185652007018	ABC-ATPase subunit interface; other site
1185652007019	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1185652007020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652007021	dimer interface [polypeptide binding]; other site
1185652007022	conserved gate region; other site
1185652007023	putative PBP binding loops; other site
1185652007024	ABC-ATPase subunit interface; other site
1185652007025	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
1185652007026	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652007027	Walker A/P-loop; other site
1185652007028	ATP binding site [chemical binding]; other site
1185652007029	Q-loop/lid; other site
1185652007030	ABC transporter signature motif; other site
1185652007031	Walker B; other site
1185652007032	D-loop; other site
1185652007033	H-loop/switch region; other site
1185652007034	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652007035	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652007036	Walker A/P-loop; other site
1185652007037	ATP binding site [chemical binding]; other site
1185652007038	Q-loop/lid; other site
1185652007039	ABC transporter signature motif; other site
1185652007040	Walker B; other site
1185652007041	D-loop; other site
1185652007042	H-loop/switch region; other site
1185652007043	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652007044	alpha-galactosidase; Provisional; Region: PRK15076
1185652007045	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
1185652007046	NAD binding site [chemical binding]; other site
1185652007047	sugar binding site [chemical binding]; other site
1185652007048	divalent metal binding site [ion binding]; other site
1185652007049	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1185652007050	dimer interface [polypeptide binding]; other site
1185652007051	malonyl-CoA synthase; Validated; Region: PRK07514
1185652007052	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
1185652007053	acyl-activating enzyme (AAE) consensus motif; other site
1185652007054	active site
1185652007055	AMP binding site [chemical binding]; other site
1185652007056	CoA binding site [chemical binding]; other site
1185652007057	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
1185652007058	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652007059	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1185652007060	DNA-binding site [nucleotide binding]; DNA binding site
1185652007061	FCD domain; Region: FCD; pfam07729
1185652007062	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1185652007063	thiamine phosphate binding site [chemical binding]; other site
1185652007064	active site
1185652007065	pyrophosphate binding site [ion binding]; other site
1185652007066	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1185652007067	ThiS interaction site; other site
1185652007068	putative active site [active]
1185652007069	tetramer interface [polypeptide binding]; other site
1185652007070	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1185652007071	thiS-thiF/thiG interaction site; other site
1185652007072	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1185652007073	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1185652007074	ThiC-associated domain; Region: ThiC-associated; pfam13667
1185652007075	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
1185652007076	lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317
1185652007077	active site
1185652007078	homopentamer interface [polypeptide binding]; other site
1185652007079	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652007080	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652007081	DNA binding site [nucleotide binding]
1185652007082	domain linker motif; other site
1185652007083	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1185652007084	dimerization interface [polypeptide binding]; other site
1185652007085	ligand binding site [chemical binding]; other site
1185652007086	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1185652007087	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652007088	substrate binding pocket [chemical binding]; other site
1185652007089	membrane-bound complex binding site; other site
1185652007090	hinge residues; other site
1185652007091	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1185652007092	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652007093	dimer interface [polypeptide binding]; other site
1185652007094	conserved gate region; other site
1185652007095	putative PBP binding loops; other site
1185652007096	ABC-ATPase subunit interface; other site
1185652007097	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1185652007098	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1185652007099	Walker A/P-loop; other site
1185652007100	ATP binding site [chemical binding]; other site
1185652007101	Q-loop/lid; other site
1185652007102	ABC transporter signature motif; other site
1185652007103	Walker B; other site
1185652007104	D-loop; other site
1185652007105	H-loop/switch region; other site
1185652007106	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652007107	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1185652007108	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1185652007109	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1185652007110	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1185652007111	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1185652007112	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1185652007113	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1185652007114	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1185652007115	catalytic loop [active]
1185652007116	iron binding site [ion binding]; other site
1185652007117	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1185652007118	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1185652007119	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1185652007120	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652007121	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1185652007122	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
1185652007123	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1185652007124	ligand binding site [chemical binding]; other site
1185652007125	dimerization interface [polypeptide binding]; other site
1185652007126	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5618
1185652007127	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1185652007128	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652007129	Walker A/P-loop; other site
1185652007130	ATP binding site [chemical binding]; other site
1185652007131	Q-loop/lid; other site
1185652007132	ABC transporter signature motif; other site
1185652007133	Walker B; other site
1185652007134	D-loop; other site
1185652007135	H-loop/switch region; other site
1185652007136	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652007137	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652007138	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652007139	TM-ABC transporter signature motif; other site
1185652007140	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652007141	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652007142	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1185652007143	transcriptional regulator NanR; Provisional; Region: PRK03837
1185652007144	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652007145	DNA-binding site [nucleotide binding]; DNA binding site
1185652007146	FCD domain; Region: FCD; pfam07729
1185652007147	Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850
1185652007148	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
1185652007149	dimer interface [polypeptide binding]; other site
1185652007150	catalytic residue [active]
1185652007151	metal binding site [ion binding]; metal-binding site
1185652007152	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1185652007153	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1185652007154	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652007155	substrate binding pocket [chemical binding]; other site
1185652007156	membrane-bound complex binding site; other site
1185652007157	hinge residues; other site
1185652007158	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652007159	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1185652007160	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1185652007161	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652007162	dimer interface [polypeptide binding]; other site
1185652007163	conserved gate region; other site
1185652007164	putative PBP binding loops; other site
1185652007165	ABC-ATPase subunit interface; other site
1185652007166	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1185652007167	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1185652007168	substrate binding site [chemical binding]; other site
1185652007169	ATP binding site [chemical binding]; other site
1185652007170	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1185652007171	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
1185652007172	putative active site [active]
1185652007173	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1185652007174	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1185652007175	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652007176	DNA-binding site [nucleotide binding]; DNA binding site
1185652007177	UTRA domain; Region: UTRA; pfam07702
1185652007178	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1185652007179	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652007180	active site
1185652007181	phosphorylation site [posttranslational modification]
1185652007182	intermolecular recognition site; other site
1185652007183	dimerization interface [polypeptide binding]; other site
1185652007184	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652007185	Walker A motif; other site
1185652007186	ATP binding site [chemical binding]; other site
1185652007187	Walker B motif; other site
1185652007188	arginine finger; other site
1185652007189	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
1185652007190	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
1185652007191	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652007192	dimer interface [polypeptide binding]; other site
1185652007193	phosphorylation site [posttranslational modification]
1185652007194	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652007195	ATP binding site [chemical binding]; other site
1185652007196	Mg2+ binding site [ion binding]; other site
1185652007197	G-X-G motif; other site
1185652007198	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
1185652007199	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1185652007200	Response regulator receiver domain; Region: Response_reg; pfam00072
1185652007201	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652007202	active site
1185652007203	phosphorylation site [posttranslational modification]
1185652007204	intermolecular recognition site; other site
1185652007205	dimerization interface [polypeptide binding]; other site
1185652007206	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652007207	DNA binding residues [nucleotide binding]
1185652007208	dimerization interface [polypeptide binding]; other site
1185652007209	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1185652007210	Na binding site [ion binding]; other site
1185652007211	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652007212	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652007213	dimer interface [polypeptide binding]; other site
1185652007214	phosphorylation site [posttranslational modification]
1185652007215	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652007216	ATP binding site [chemical binding]; other site
1185652007217	Mg2+ binding site [ion binding]; other site
1185652007218	G-X-G motif; other site
1185652007219	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1185652007220	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652007221	active site
1185652007222	phosphorylation site [posttranslational modification]
1185652007223	intermolecular recognition site; other site
1185652007224	dimerization interface [polypeptide binding]; other site
1185652007225	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
1185652007226	putative metal binding site [ion binding]; other site
1185652007227	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1185652007228	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
1185652007229	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
1185652007230	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1185652007231	DNA-binding site [nucleotide binding]; DNA binding site
1185652007232	RNA-binding motif; other site
1185652007233	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
1185652007234	Predicted transcriptional regulator [Transcription]; Region: COG3905
1185652007235	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1185652007236	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652007237	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1185652007238	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1185652007239	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652007240	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1185652007241	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652007242	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1185652007243	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652007244	YCII-related domain; Region: YCII; cl00999
1185652007245	Domain of unknown function DUF302; Region: DUF302; pfam03625
1185652007246	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652007247	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1185652007248	putative substrate translocation pore; other site
1185652007249	Cupin domain; Region: Cupin_2; cl17218
1185652007250	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652007251	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652007252	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1185652007253	dimerization interface [polypeptide binding]; other site
1185652007254	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
1185652007255	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652007256	NAD(P) binding site [chemical binding]; other site
1185652007257	active site
1185652007258	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1185652007259	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
1185652007260	active site
1185652007261	nucleophile elbow; other site
1185652007262	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
1185652007263	hypothetical protein; Provisional; Region: PRK05409
1185652007264	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
1185652007265	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1185652007266	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1185652007267	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652007268	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
1185652007269	cyclase homology domain; Region: CHD; cd07302
1185652007270	nucleotidyl binding site; other site
1185652007271	metal binding site [ion binding]; metal-binding site
1185652007272	dimer interface [polypeptide binding]; other site
1185652007273	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
1185652007274	Cupin; Region: Cupin_6; pfam12852
1185652007275	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1185652007276	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652007277	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1185652007278	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652007279	putative substrate translocation pore; other site
1185652007280	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
1185652007281	Moco binding site; other site
1185652007282	metal coordination site [ion binding]; other site
1185652007283	dimerization interface [polypeptide binding]; other site
1185652007284	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1185652007285	Protein of unknown function (DUF938); Region: DUF938; pfam06080
1185652007286	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
1185652007287	cyclase homology domain; Region: CHD; cd07302
1185652007288	nucleotidyl binding site; other site
1185652007289	metal binding site [ion binding]; metal-binding site
1185652007290	dimer interface [polypeptide binding]; other site
1185652007291	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
1185652007292	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1185652007293	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1185652007294	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1185652007295	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1185652007296	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652007297	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1185652007298	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1185652007299	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652007300	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652007301	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1185652007302	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1185652007303	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652007304	Transposase; Region: HTH_Tnp_1; pfam01527
1185652007305	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1185652007306	Predicted ATPase [General function prediction only]; Region: COG3899
1185652007307	AAA ATPase domain; Region: AAA_16; pfam13191
1185652007308	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1185652007309	Cupin domain; Region: Cupin_2; cl17218
1185652007310	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1185652007311	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1185652007312	Walker A/P-loop; other site
1185652007313	ATP binding site [chemical binding]; other site
1185652007314	Q-loop/lid; other site
1185652007315	ABC transporter signature motif; other site
1185652007316	Walker B; other site
1185652007317	D-loop; other site
1185652007318	H-loop/switch region; other site
1185652007319	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1185652007320	Predicted secreted hydrolase [General function prediction only]; Region: COG5621
1185652007321	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652007322	cyclase homology domain; Region: CHD; cd07302
1185652007323	nucleotidyl binding site; other site
1185652007324	metal binding site [ion binding]; metal-binding site
1185652007325	dimer interface [polypeptide binding]; other site
1185652007326	Predicted integral membrane protein [Function unknown]; Region: COG5616
1185652007327	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652007328	TPR motif; other site
1185652007329	TPR repeat; Region: TPR_11; pfam13414
1185652007330	binding surface
1185652007331	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652007332	TPR motif; other site
1185652007333	binding surface
1185652007334	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
1185652007335	putative catalytic residues [active]
1185652007336	Transposase domain (DUF772); Region: DUF772; pfam05598
1185652007337	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1185652007338	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1185652007339	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1185652007340	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652007341	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1185652007342	Transposase; Region: HTH_Tnp_1; pfam01527
1185652007343	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
1185652007344	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1185652007345	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1185652007346	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1185652007347	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1185652007348	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1185652007349	dimer interface [polypeptide binding]; other site
1185652007350	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1185652007351	intersubunit interface [polypeptide binding]; other site
1185652007352	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1185652007353	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1185652007354	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1185652007355	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1185652007356	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
1185652007357	P-loop, Walker A motif; other site
1185652007358	Base recognition motif; other site
1185652007359	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1185652007360	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
1185652007361	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
1185652007362	dimer interface [polypeptide binding]; other site
1185652007363	structural Zn2+ binding site [ion binding]; other site
1185652007364	metal binding site 1 [ion binding]; metal-binding site
1185652007365	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1185652007366	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1185652007367	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1185652007368	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1185652007369	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1185652007370	N-terminal plug; other site
1185652007371	ligand-binding site [chemical binding]; other site
1185652007372	ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048
1185652007373	Periplasmic binding protein TroA_f.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139
1185652007374	putative ligand binding residues [chemical binding]; other site
1185652007375	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1185652007376	IucA / IucC family; Region: IucA_IucC; pfam04183
1185652007377	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1185652007378	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
1185652007379	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1185652007380	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1185652007381	dimer interface [polypeptide binding]; other site
1185652007382	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652007383	catalytic residue [active]
1185652007384	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1185652007385	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842
1185652007386	dimer interface [polypeptide binding]; other site
1185652007387	active site
1185652007388	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1185652007389	catalytic residues [active]
1185652007390	substrate binding site [chemical binding]; other site
1185652007391	ParB-like nuclease domain; Region: ParBc; pfam02195
1185652007392	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
1185652007393	putative metal binding residues [ion binding]; other site
1185652007394	signature motif; other site
1185652007395	dimer interface [polypeptide binding]; other site
1185652007396	active site
1185652007397	polyP binding site; other site
1185652007398	substrate binding site [chemical binding]; other site
1185652007399	acceptor-phosphate pocket; other site
1185652007400	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
1185652007401	Phosphate transporter family; Region: PHO4; pfam01384
1185652007402	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1185652007403	dimerization interface [polypeptide binding]; other site
1185652007404	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652007405	dimer interface [polypeptide binding]; other site
1185652007406	phosphorylation site [posttranslational modification]
1185652007407	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652007408	ATP binding site [chemical binding]; other site
1185652007409	Mg2+ binding site [ion binding]; other site
1185652007410	G-X-G motif; other site
1185652007411	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652007412	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652007413	active site
1185652007414	phosphorylation site [posttranslational modification]
1185652007415	intermolecular recognition site; other site
1185652007416	dimerization interface [polypeptide binding]; other site
1185652007417	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652007418	DNA binding site [nucleotide binding]
1185652007419	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1185652007420	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1185652007421	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1185652007422	DNA binding residues [nucleotide binding]
1185652007423	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1185652007424	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1185652007425	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1185652007426	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1185652007427	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652007428	Walker A/P-loop; other site
1185652007429	ATP binding site [chemical binding]; other site
1185652007430	Q-loop/lid; other site
1185652007431	ABC transporter signature motif; other site
1185652007432	Walker B; other site
1185652007433	D-loop; other site
1185652007434	H-loop/switch region; other site
1185652007435	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652007436	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1185652007437	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652007438	Walker A/P-loop; other site
1185652007439	ATP binding site [chemical binding]; other site
1185652007440	Q-loop/lid; other site
1185652007441	ABC transporter signature motif; other site
1185652007442	Walker B; other site
1185652007443	D-loop; other site
1185652007444	H-loop/switch region; other site
1185652007445	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1185652007446	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1185652007447	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652007448	dimer interface [polypeptide binding]; other site
1185652007449	conserved gate region; other site
1185652007450	putative PBP binding loops; other site
1185652007451	ABC-ATPase subunit interface; other site
1185652007452	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1185652007453	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652007454	dimer interface [polypeptide binding]; other site
1185652007455	conserved gate region; other site
1185652007456	ABC-ATPase subunit interface; other site
1185652007457	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1185652007458	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1185652007459	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1185652007460	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1185652007461	Bacterial transcriptional regulator; Region: IclR; pfam01614
1185652007462	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
1185652007463	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
1185652007464	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1185652007465	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1185652007466	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1185652007467	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1185652007468	nudix motif; other site
1185652007469	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
1185652007470	DNA polymerase III subunit epsilon; Validated; Region: PRK09182
1185652007471	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1185652007472	active site
1185652007473	catalytic site [active]
1185652007474	substrate binding site [chemical binding]; other site
1185652007475	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652007476	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
1185652007477	DNA polymerase IV; Validated; Region: PRK02406
1185652007478	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1185652007479	active site
1185652007480	DNA binding site [nucleotide binding]
1185652007481	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
1185652007482	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
1185652007483	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1185652007484	short chain dehydrogenase; Provisional; Region: PRK06180
1185652007485	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1185652007486	NADP binding site [chemical binding]; other site
1185652007487	active site
1185652007488	steroid binding site; other site
1185652007489	Uncharacterized protein conserved in archaea (DUF2121); Region: DUF2121; cl17852
1185652007490	betaine aldehyde dehydrogenase; Region: PLN02467
1185652007491	Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110
1185652007492	NAD(P) binding site [chemical binding]; other site
1185652007493	catalytic residues [active]
1185652007494	catalytic residues [active]
1185652007495	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1185652007496	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1185652007497	conserved cys residue [active]
1185652007498	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652007499	allantoate amidohydrolase; Reviewed; Region: PRK12893
1185652007500	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1185652007501	active site
1185652007502	metal binding site [ion binding]; metal-binding site
1185652007503	dimer interface [polypeptide binding]; other site
1185652007504	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
1185652007505	Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434
1185652007506	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1185652007507	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1185652007508	substrate binding site [chemical binding]; other site
1185652007509	ATP binding site [chemical binding]; other site
1185652007510	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1185652007511	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
1185652007512	active site
1185652007513	substrate binding pocket [chemical binding]; other site
1185652007514	homodimer interaction site [polypeptide binding]; other site
1185652007515	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652007516	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652007517	TM-ABC transporter signature motif; other site
1185652007518	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1185652007519	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652007520	Walker A/P-loop; other site
1185652007521	ATP binding site [chemical binding]; other site
1185652007522	Q-loop/lid; other site
1185652007523	ABC transporter signature motif; other site
1185652007524	Walker B; other site
1185652007525	D-loop; other site
1185652007526	H-loop/switch region; other site
1185652007527	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1185652007528	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1185652007529	ligand binding site [chemical binding]; other site
1185652007530	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652007531	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652007532	DNA binding site [nucleotide binding]
1185652007533	domain linker motif; other site
1185652007534	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293
1185652007535	putative dimerization interface [polypeptide binding]; other site
1185652007536	putative ligand binding site [chemical binding]; other site
1185652007537	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1185652007538	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652007539	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1185652007540	dimerization interface [polypeptide binding]; other site
1185652007541	substrate binding pocket [chemical binding]; other site
1185652007542	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652007543	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
1185652007544	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1185652007545	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
1185652007546	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1185652007547	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1185652007548	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
1185652007549	putative NAD(P) binding site [chemical binding]; other site
1185652007550	active site
1185652007551	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1185652007552	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
1185652007553	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652007554	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652007555	active site
1185652007556	phosphorylation site [posttranslational modification]
1185652007557	intermolecular recognition site; other site
1185652007558	dimerization interface [polypeptide binding]; other site
1185652007559	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
1185652007560	DNA binding residues [nucleotide binding]
1185652007561	GAF domain; Region: GAF; pfam01590
1185652007562	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1185652007563	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1185652007564	Mg2+ binding site [ion binding]; other site
1185652007565	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1185652007566	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
1185652007567	putative ligand binding site [chemical binding]; other site
1185652007568	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1185652007569	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652007570	Walker A/P-loop; other site
1185652007571	ATP binding site [chemical binding]; other site
1185652007572	Q-loop/lid; other site
1185652007573	ABC transporter signature motif; other site
1185652007574	Walker B; other site
1185652007575	D-loop; other site
1185652007576	H-loop/switch region; other site
1185652007577	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652007578	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652007579	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652007580	TM-ABC transporter signature motif; other site
1185652007581	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652007582	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652007583	TM-ABC transporter signature motif; other site
1185652007584	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1185652007585	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1185652007586	prevent-host-death family protein; Region: phd_fam; TIGR01552
1185652007587	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1185652007588	oligomeric interface; other site
1185652007589	putative active site [active]
1185652007590	homodimer interface [polypeptide binding]; other site
1185652007591	TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936
1185652007592	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1185652007593	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1185652007594	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652007595	Walker A/P-loop; other site
1185652007596	ATP binding site [chemical binding]; other site
1185652007597	Q-loop/lid; other site
1185652007598	ABC transporter signature motif; other site
1185652007599	Walker B; other site
1185652007600	D-loop; other site
1185652007601	H-loop/switch region; other site
1185652007602	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652007603	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652007604	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652007605	TM-ABC transporter signature motif; other site
1185652007606	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652007607	TM-ABC transporter signature motif; other site
1185652007608	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
1185652007609	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652007610	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1185652007611	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1185652007612	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1185652007613	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1185652007614	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
1185652007615	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1185652007616	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
1185652007617	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1185652007618	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1185652007619	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1185652007620	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1185652007621	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1185652007622	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1185652007623	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
1185652007624	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1185652007625	inhibitor-cofactor binding pocket; inhibition site
1185652007626	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652007627	catalytic residue [active]
1185652007628	DNA polymerase III subunit epsilon; Validated; Region: PRK09182
1185652007629	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1185652007630	active site
1185652007631	catalytic site [active]
1185652007632	substrate binding site [chemical binding]; other site
1185652007633	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
1185652007634	PIN domain; Region: PIN_3; pfam13470
1185652007635	Helix-turn-helix domain; Region: HTH_17; cl17695
1185652007636	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1185652007637	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1185652007638	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1185652007639	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652007640	H-loop/switch region; other site
1185652007641	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652007642	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652007643	DNA binding site [nucleotide binding]
1185652007644	domain linker motif; other site
1185652007645	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1185652007646	putative dimerization interface [polypeptide binding]; other site
1185652007647	putative ligand binding site [chemical binding]; other site
1185652007648	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1185652007649	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1185652007650	AAA domain; Region: AAA_33; pfam13671
1185652007651	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1185652007652	ATP-binding site [chemical binding]; other site
1185652007653	Gluconate-6-phosphate binding site [chemical binding]; other site
1185652007654	gluconate 5-dehydrogenase; Provisional; Region: PRK07523
1185652007655	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1185652007656	NADP binding site [chemical binding]; other site
1185652007657	homodimer interface [polypeptide binding]; other site
1185652007658	active site
1185652007659	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1185652007660	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
1185652007661	putative ligand binding site [chemical binding]; other site
1185652007662	NAD binding site [chemical binding]; other site
1185652007663	catalytic site [active]
1185652007664	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
1185652007665	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
1185652007666	putative NAD(P) binding site [chemical binding]; other site
1185652007667	catalytic Zn binding site [ion binding]; other site
1185652007668	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1185652007669	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1185652007670	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1185652007671	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1185652007672	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1185652007673	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
1185652007674	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
1185652007675	active site
1185652007676	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652007677	extended (e) SDRs; Region: SDR_e; cd08946
1185652007678	NAD(P) binding site [chemical binding]; other site
1185652007679	active site
1185652007680	substrate binding site [chemical binding]; other site
1185652007681	dihydroxy-acid dehydratase; Provisional; Region: PRK13016
1185652007682	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1185652007683	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652007684	DNA-binding site [nucleotide binding]; DNA binding site
1185652007685	FCD domain; Region: FCD; pfam07729
1185652007686	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1185652007687	inhibitor site; inhibition site
1185652007688	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1185652007689	active site
1185652007690	dimer interface [polypeptide binding]; other site
1185652007691	catalytic residue [active]
1185652007692	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1185652007693	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1185652007694	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1185652007695	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1185652007696	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1185652007697	carboxyltransferase (CT) interaction site; other site
1185652007698	biotinylation site [posttranslational modification]; other site
1185652007699	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1185652007700	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1185652007701	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1185652007702	hypothetical protein; Provisional; Region: PRK05463
1185652007703	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1185652007704	putative active site [active]
1185652007705	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1185652007706	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1185652007707	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652007708	DNA-binding site [nucleotide binding]; DNA binding site
1185652007709	FCD domain; Region: FCD; pfam07729
1185652007710	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1185652007711	MULE transposase domain; Region: MULE; pfam10551
1185652007712	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652007713	dimerization interface [polypeptide binding]; other site
1185652007714	putative DNA binding site [nucleotide binding]; other site
1185652007715	putative Zn2+ binding site [ion binding]; other site
1185652007716	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1185652007717	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1185652007718	active site
1185652007719	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
1185652007720	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
1185652007721	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1185652007722	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1185652007723	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
1185652007724	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1185652007725	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1185652007726	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652007727	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
1185652007728	homotrimer interaction site [polypeptide binding]; other site
1185652007729	putative active site [active]
1185652007730	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1185652007731	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652007732	NAD(P) binding site [chemical binding]; other site
1185652007733	active site
1185652007734	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1185652007735	classical (c) SDRs; Region: SDR_c; cd05233
1185652007736	NAD(P) binding site [chemical binding]; other site
1185652007737	active site
1185652007738	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1185652007739	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652007740	DNA-binding site [nucleotide binding]; DNA binding site
1185652007741	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1185652007742	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1185652007743	PYR/PP interface [polypeptide binding]; other site
1185652007744	dimer interface [polypeptide binding]; other site
1185652007745	TPP binding site [chemical binding]; other site
1185652007746	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1185652007747	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1185652007748	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652007749	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1185652007750	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652007751	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652007752	NAD(P) binding site [chemical binding]; other site
1185652007753	active site
1185652007754	aspartate aminotransferase; Provisional; Region: PRK05764
1185652007755	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652007756	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652007757	homodimer interface [polypeptide binding]; other site
1185652007758	catalytic residue [active]
1185652007759	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1185652007760	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
1185652007761	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1185652007762	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1185652007763	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1185652007764	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1185652007765	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1185652007766	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1185652007767	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1185652007768	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1185652007769	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1185652007770	inhibitor site; inhibition site
1185652007771	active site
1185652007772	dimer interface [polypeptide binding]; other site
1185652007773	catalytic residue [active]
1185652007774	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1185652007775	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652007776	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652007777	NAD(P) binding site [chemical binding]; other site
1185652007778	active site
1185652007779	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1185652007780	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652007781	DNA-binding site [nucleotide binding]; DNA binding site
1185652007782	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1185652007783	hypothetical protein; Validated; Region: PRK08245
1185652007784	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
1185652007785	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1185652007786	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1185652007787	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652007788	dimer interface [polypeptide binding]; other site
1185652007789	conserved gate region; other site
1185652007790	putative PBP binding loops; other site
1185652007791	ABC-ATPase subunit interface; other site
1185652007792	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1185652007793	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652007794	dimer interface [polypeptide binding]; other site
1185652007795	conserved gate region; other site
1185652007796	putative PBP binding loops; other site
1185652007797	ABC-ATPase subunit interface; other site
1185652007798	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1185652007799	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652007800	Walker A/P-loop; other site
1185652007801	ATP binding site [chemical binding]; other site
1185652007802	Q-loop/lid; other site
1185652007803	ABC transporter signature motif; other site
1185652007804	Walker B; other site
1185652007805	D-loop; other site
1185652007806	H-loop/switch region; other site
1185652007807	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652007808	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652007809	Walker A/P-loop; other site
1185652007810	ATP binding site [chemical binding]; other site
1185652007811	Q-loop/lid; other site
1185652007812	ABC transporter signature motif; other site
1185652007813	Walker B; other site
1185652007814	D-loop; other site
1185652007815	H-loop/switch region; other site
1185652007816	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652007817	galactonate dehydratase; Provisional; Region: PRK14017
1185652007818	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1185652007819	active site pocket [active]
1185652007820	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1185652007821	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1185652007822	active site pocket [active]
1185652007823	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
1185652007824	active site
1185652007825	catalytic residues [active]
1185652007826	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1185652007827	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652007828	DNA binding site [nucleotide binding]
1185652007829	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
1185652007830	putative ligand binding site [chemical binding]; other site
1185652007831	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1185652007832	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1185652007833	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652007834	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652007835	TM-ABC transporter signature motif; other site
1185652007836	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652007837	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652007838	TM-ABC transporter signature motif; other site
1185652007839	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
1185652007840	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652007841	Walker A/P-loop; other site
1185652007842	ATP binding site [chemical binding]; other site
1185652007843	Q-loop/lid; other site
1185652007844	ABC transporter signature motif; other site
1185652007845	Walker B; other site
1185652007846	D-loop; other site
1185652007847	H-loop/switch region; other site
1185652007848	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1185652007849	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1185652007850	Metal-binding active site; metal-binding site
1185652007851	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652007852	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652007853	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1185652007854	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652007855	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652007856	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1185652007857	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1185652007858	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1185652007859	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1185652007860	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1185652007861	substrate binding site [chemical binding]; other site
1185652007862	ATP binding site [chemical binding]; other site
1185652007863	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
1185652007864	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
1185652007865	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1185652007866	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1185652007867	PYR/PP interface [polypeptide binding]; other site
1185652007868	dimer interface [polypeptide binding]; other site
1185652007869	TPP binding site [chemical binding]; other site
1185652007870	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1185652007871	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1185652007872	TPP-binding site [chemical binding]; other site
1185652007873	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
1185652007874	Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130
1185652007875	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652007876	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1185652007877	dimerization interface [polypeptide binding]; other site
1185652007878	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652007879	dimer interface [polypeptide binding]; other site
1185652007880	phosphorylation site [posttranslational modification]
1185652007881	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652007882	ATP binding site [chemical binding]; other site
1185652007883	Mg2+ binding site [ion binding]; other site
1185652007884	G-X-G motif; other site
1185652007885	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652007886	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652007887	active site
1185652007888	phosphorylation site [posttranslational modification]
1185652007889	intermolecular recognition site; other site
1185652007890	dimerization interface [polypeptide binding]; other site
1185652007891	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652007892	DNA binding site [nucleotide binding]
1185652007893	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
1185652007894	dimer interface [polypeptide binding]; other site
1185652007895	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476
1185652007896	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1185652007897	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1185652007898	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652007899	DNA-binding site [nucleotide binding]; DNA binding site
1185652007900	FCD domain; Region: FCD; pfam07729
1185652007901	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652007902	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1185652007903	substrate binding pocket [chemical binding]; other site
1185652007904	membrane-bound complex binding site; other site
1185652007905	hinge residues; other site
1185652007906	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1185652007907	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1185652007908	Walker A/P-loop; other site
1185652007909	ATP binding site [chemical binding]; other site
1185652007910	Q-loop/lid; other site
1185652007911	ABC transporter signature motif; other site
1185652007912	Walker B; other site
1185652007913	D-loop; other site
1185652007914	H-loop/switch region; other site
1185652007915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652007916	dimer interface [polypeptide binding]; other site
1185652007917	conserved gate region; other site
1185652007918	putative PBP binding loops; other site
1185652007919	ABC-ATPase subunit interface; other site
1185652007920	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1185652007921	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652007922	dimer interface [polypeptide binding]; other site
1185652007923	conserved gate region; other site
1185652007924	putative PBP binding loops; other site
1185652007925	ABC-ATPase subunit interface; other site
1185652007926	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1185652007927	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1185652007928	inhibitor site; inhibition site
1185652007929	active site
1185652007930	dimer interface [polypeptide binding]; other site
1185652007931	catalytic residue [active]
1185652007932	Proline racemase; Region: Pro_racemase; pfam05544
1185652007933	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1185652007934	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652007935	betaine aldehyde dehydrogenase; Region: PLN02467
1185652007936	Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110
1185652007937	NAD(P) binding site [chemical binding]; other site
1185652007938	catalytic residues [active]
1185652007939	catalytic residues [active]
1185652007940	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
1185652007941	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1185652007942	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1185652007943	classical (c) SDRs; Region: SDR_c; cd05233
1185652007944	NAD(P) binding site [chemical binding]; other site
1185652007945	active site
1185652007946	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1185652007947	classical (c) SDRs; Region: SDR_c; cd05233
1185652007948	NAD(P) binding site [chemical binding]; other site
1185652007949	active site
1185652007950	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652007951	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1185652007952	substrate binding pocket [chemical binding]; other site
1185652007953	membrane-bound complex binding site; other site
1185652007954	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1185652007955	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
1185652007956	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1185652007957	ligand binding site [chemical binding]; other site
1185652007958	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
1185652007959	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1185652007960	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1185652007961	BA14K-like protein; Region: BA14K; pfam07886
1185652007962	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
1185652007963	pseudoazurin; Region: pseudoazurin; TIGR02375
1185652007964	PAS fold; Region: PAS_7; pfam12860
1185652007965	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652007966	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652007967	dimer interface [polypeptide binding]; other site
1185652007968	phosphorylation site [posttranslational modification]
1185652007969	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652007970	ATP binding site [chemical binding]; other site
1185652007971	Mg2+ binding site [ion binding]; other site
1185652007972	G-X-G motif; other site
1185652007973	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652007974	Response regulator receiver domain; Region: Response_reg; pfam00072
1185652007975	active site
1185652007976	phosphorylation site [posttranslational modification]
1185652007977	intermolecular recognition site; other site
1185652007978	dimerization interface [polypeptide binding]; other site
1185652007979	Uncharacterized conserved protein [Function unknown]; Region: COG3287
1185652007980	FIST N domain; Region: FIST; pfam08495
1185652007981	FIST C domain; Region: FIST_C; pfam10442
1185652007982	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652007983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652007984	active site
1185652007985	phosphorylation site [posttranslational modification]
1185652007986	intermolecular recognition site; other site
1185652007987	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652007988	DNA binding residues [nucleotide binding]
1185652007989	dimerization interface [polypeptide binding]; other site
1185652007990	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
1185652007991	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
1185652007992	dimer interface [polypeptide binding]; other site
1185652007993	Trp docking motif [polypeptide binding]; other site
1185652007994	active site
1185652007995	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1185652007996	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
1185652007997	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
1185652007998	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
1185652007999	putative active site [active]
1185652008000	putative FMN binding site [chemical binding]; other site
1185652008001	putative substrate binding site [chemical binding]; other site
1185652008002	putative catalytic residue [active]
1185652008003	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652008004	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652008005	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652008006	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1185652008007	Walker A/P-loop; other site
1185652008008	ATP binding site [chemical binding]; other site
1185652008009	Q-loop/lid; other site
1185652008010	ABC transporter signature motif; other site
1185652008011	Walker B; other site
1185652008012	D-loop; other site
1185652008013	H-loop/switch region; other site
1185652008014	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1185652008015	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1185652008016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652008017	dimer interface [polypeptide binding]; other site
1185652008018	conserved gate region; other site
1185652008019	putative PBP binding loops; other site
1185652008020	ABC-ATPase subunit interface; other site
1185652008021	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1185652008022	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1185652008023	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1185652008024	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1185652008025	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652008026	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
1185652008027	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
1185652008028	putative active site [active]
1185652008029	putative FMN binding site [chemical binding]; other site
1185652008030	putative substrate binding site [chemical binding]; other site
1185652008031	putative catalytic residue [active]
1185652008032	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
1185652008033	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1185652008034	Ligand binding site [chemical binding]; other site
1185652008035	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1185652008036	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1185652008037	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1185652008038	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1185652008039	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1185652008040	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1185652008041	substrate binding site [chemical binding]; other site
1185652008042	catalytic Zn binding site [ion binding]; other site
1185652008043	NAD binding site [chemical binding]; other site
1185652008044	structural Zn binding site [ion binding]; other site
1185652008045	dimer interface [polypeptide binding]; other site
1185652008046	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1185652008047	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
1185652008048	FAD binding pocket [chemical binding]; other site
1185652008049	FAD binding motif [chemical binding]; other site
1185652008050	phosphate binding motif [ion binding]; other site
1185652008051	beta-alpha-beta structure motif; other site
1185652008052	NAD binding pocket [chemical binding]; other site
1185652008053	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1185652008054	catalytic loop [active]
1185652008055	iron binding site [ion binding]; other site
1185652008056	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1185652008057	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1185652008058	[2Fe-2S] cluster binding site [ion binding]; other site
1185652008059	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
1185652008060	putative alpha subunit interface [polypeptide binding]; other site
1185652008061	putative active site [active]
1185652008062	putative substrate binding site [chemical binding]; other site
1185652008063	Fe binding site [ion binding]; other site
1185652008064	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1185652008065	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652008066	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1185652008067	dimerization interface [polypeptide binding]; other site
1185652008068	substrate binding pocket [chemical binding]; other site
1185652008069	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1185652008070	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212
1185652008071	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
1185652008072	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1185652008073	MULE transposase domain; Region: MULE; pfam10551
1185652008074	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652008075	cyclase homology domain; Region: CHD; cd07302
1185652008076	nucleotidyl binding site; other site
1185652008077	metal binding site [ion binding]; metal-binding site
1185652008078	dimer interface [polypeptide binding]; other site
1185652008079	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1185652008080	putative hydrophobic ligand binding site [chemical binding]; other site
1185652008081	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
1185652008082	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1185652008083	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652008084	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652008085	active site
1185652008086	phosphorylation site [posttranslational modification]
1185652008087	intermolecular recognition site; other site
1185652008088	dimerization interface [polypeptide binding]; other site
1185652008089	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652008090	DNA binding residues [nucleotide binding]
1185652008091	dimerization interface [polypeptide binding]; other site
1185652008092	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1185652008093	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652008094	ATP binding site [chemical binding]; other site
1185652008095	Mg2+ binding site [ion binding]; other site
1185652008096	G-X-G motif; other site
1185652008097	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1185652008098	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652008099	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652008100	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
1185652008101	putative substrate binding pocket [chemical binding]; other site
1185652008102	putative dimerization interface [polypeptide binding]; other site
1185652008103	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652008104	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1185652008105	putative substrate translocation pore; other site
1185652008106	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1185652008107	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1185652008108	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
1185652008109	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1185652008110	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
1185652008111	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1185652008112	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1185652008113	catalytic residue [active]
1185652008114	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1185652008115	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652008116	dimer interface [polypeptide binding]; other site
1185652008117	conserved gate region; other site
1185652008118	putative PBP binding loops; other site
1185652008119	ABC-ATPase subunit interface; other site
1185652008120	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1185652008121	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652008122	dimer interface [polypeptide binding]; other site
1185652008123	conserved gate region; other site
1185652008124	putative PBP binding loops; other site
1185652008125	ABC-ATPase subunit interface; other site
1185652008126	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1185652008127	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652008128	substrate binding pocket [chemical binding]; other site
1185652008129	membrane-bound complex binding site; other site
1185652008130	hinge residues; other site
1185652008131	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
1185652008132	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1185652008133	Walker A/P-loop; other site
1185652008134	ATP binding site [chemical binding]; other site
1185652008135	Q-loop/lid; other site
1185652008136	ABC transporter signature motif; other site
1185652008137	Walker B; other site
1185652008138	D-loop; other site
1185652008139	H-loop/switch region; other site
1185652008140	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652008141	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652008142	putative DNA binding site [nucleotide binding]; other site
1185652008143	putative Zn2+ binding site [ion binding]; other site
1185652008144	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652008145	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
1185652008146	putative active site [active]
1185652008147	putative metal binding site [ion binding]; other site
1185652008148	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
1185652008149	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1185652008150	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1185652008151	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652008152	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1185652008153	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1185652008154	catalytic loop [active]
1185652008155	iron binding site [ion binding]; other site
1185652008156	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1185652008157	Cytochrome P450; Region: p450; cl12078
1185652008158	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652008159	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652008160	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1185652008161	substrate binding pocket [chemical binding]; other site
1185652008162	dimerization interface [polypeptide binding]; other site
1185652008163	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
1185652008164	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652008165	DNA-binding site [nucleotide binding]; DNA binding site
1185652008166	FCD domain; Region: FCD; pfam07729
1185652008167	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1185652008168	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
1185652008169	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
1185652008170	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652008171	DNA-binding site [nucleotide binding]; DNA binding site
1185652008172	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1185652008173	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1185652008174	DNA-binding site [nucleotide binding]; DNA binding site
1185652008175	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1185652008176	aconitate hydratase; Provisional; Region: acnA; PRK12881
1185652008177	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1185652008178	substrate binding site [chemical binding]; other site
1185652008179	ligand binding site [chemical binding]; other site
1185652008180	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
1185652008181	substrate binding site [chemical binding]; other site
1185652008182	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
1185652008183	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1185652008184	putative active site [active]
1185652008185	catalytic residue [active]
1185652008186	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652008187	HAMP domain; Region: HAMP; pfam00672
1185652008188	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1185652008189	dimer interface [polypeptide binding]; other site
1185652008190	phosphorylation site [posttranslational modification]
1185652008191	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652008192	ATP binding site [chemical binding]; other site
1185652008193	Mg2+ binding site [ion binding]; other site
1185652008194	G-X-G motif; other site
1185652008195	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652008196	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652008197	active site
1185652008198	phosphorylation site [posttranslational modification]
1185652008199	intermolecular recognition site; other site
1185652008200	dimerization interface [polypeptide binding]; other site
1185652008201	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652008202	DNA binding site [nucleotide binding]
1185652008203	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
1185652008204	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1185652008205	active site
1185652008206	metal binding site [ion binding]; metal-binding site
1185652008207	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652008208	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1185652008209	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652008210	non-specific DNA binding site [nucleotide binding]; other site
1185652008211	salt bridge; other site
1185652008212	sequence-specific DNA binding site [nucleotide binding]; other site
1185652008213	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1185652008214	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1185652008215	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1185652008216	Aspartase; Region: Aspartase; cd01357
1185652008217	active sites [active]
1185652008218	tetramer interface [polypeptide binding]; other site
1185652008219	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
1185652008220	active site
1185652008221	homodimer interface [polypeptide binding]; other site
1185652008222	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
1185652008223	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
1185652008224	ethanolamine permease; Region: 2A0305; TIGR00908
1185652008225	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1185652008226	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1185652008227	Walker A/P-loop; other site
1185652008228	ATP binding site [chemical binding]; other site
1185652008229	Q-loop/lid; other site
1185652008230	ABC transporter signature motif; other site
1185652008231	Walker B; other site
1185652008232	D-loop; other site
1185652008233	H-loop/switch region; other site
1185652008234	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1185652008235	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1185652008236	FtsX-like permease family; Region: FtsX; pfam02687
1185652008237	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1185652008238	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652008239	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1185652008240	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1185652008241	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1185652008242	TrkA-N domain; Region: TrkA_N; pfam02254
1185652008243	TrkA-C domain; Region: TrkA_C; pfam02080
1185652008244	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
1185652008245	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1185652008246	Integrase core domain; Region: rve; pfam00665
1185652008247	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1185652008248	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1185652008249	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1185652008250	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1185652008251	Ligand Binding Site [chemical binding]; other site
1185652008252	HprK-related kinase A; Region: HprK_rel_A; TIGR04352
1185652008253	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1185652008254	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652008255	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1185652008256	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652008257	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1185652008258	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652008259	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1185652008260	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
1185652008261	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1185652008262	Histidine kinase; Region: HisKA_3; pfam07730
1185652008263	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652008264	ATP binding site [chemical binding]; other site
1185652008265	Mg2+ binding site [ion binding]; other site
1185652008266	G-X-G motif; other site
1185652008267	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652008268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652008269	active site
1185652008270	phosphorylation site [posttranslational modification]
1185652008271	intermolecular recognition site; other site
1185652008272	dimerization interface [polypeptide binding]; other site
1185652008273	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652008274	DNA binding residues [nucleotide binding]
1185652008275	dimerization interface [polypeptide binding]; other site
1185652008276	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1185652008277	MarR family; Region: MarR; pfam01047
1185652008278	Cytochrome c; Region: Cytochrom_C; pfam00034
1185652008279	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1185652008280	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652008281	S-adenosylmethionine binding site [chemical binding]; other site
1185652008282	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
1185652008283	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1185652008284	catalytic residues [active]
1185652008285	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1185652008286	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1185652008287	Cu(I) binding site [ion binding]; other site
1185652008288	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1185652008289	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1185652008290	catalytic residues [active]
1185652008291	Protein of unknown function, DUF; Region: DUF411; cl01142
1185652008292	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1185652008293	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1185652008294	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1185652008295	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1185652008296	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1185652008297	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1185652008298	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1185652008299	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
1185652008300	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
1185652008301	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652008302	YtkA-like; Region: YtkA; pfam13115
1185652008303	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
1185652008304	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
1185652008305	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
1185652008306	[2Fe-2S] cluster binding site [ion binding]; other site
1185652008307	Transposase domain (DUF772); Region: DUF772; pfam05598
1185652008308	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1185652008309	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1185652008310	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
1185652008311	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1185652008312	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1185652008313	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1185652008314	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1185652008315	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652008316	cyclase homology domain; Region: CHD; cd07302
1185652008317	nucleotidyl binding site; other site
1185652008318	metal binding site [ion binding]; metal-binding site
1185652008319	dimer interface [polypeptide binding]; other site
1185652008320	Predicted integral membrane protein [Function unknown]; Region: COG5616
1185652008321	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652008322	binding surface
1185652008323	TPR motif; other site
1185652008324	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652008325	TPR motif; other site
1185652008326	binding surface
1185652008327	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1185652008328	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1185652008329	dimerization interface [polypeptide binding]; other site
1185652008330	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1185652008331	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1185652008332	dimer interface [polypeptide binding]; other site
1185652008333	putative CheW interface [polypeptide binding]; other site
1185652008334	Response regulator receiver domain; Region: Response_reg; pfam00072
1185652008335	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652008336	active site
1185652008337	phosphorylation site [posttranslational modification]
1185652008338	intermolecular recognition site; other site
1185652008339	dimerization interface [polypeptide binding]; other site
1185652008340	PAS fold; Region: PAS_7; pfam12860
1185652008341	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652008342	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652008343	metal binding site [ion binding]; metal-binding site
1185652008344	active site
1185652008345	I-site; other site
1185652008346	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1185652008347	High-affinity nickel-transport protein; Region: NicO; cl00964
1185652008348	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1185652008349	Chromate transporter; Region: Chromate_transp; pfam02417
1185652008350	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
1185652008351	agmatinase; Region: agmatinase; TIGR01230
1185652008352	Agmatinase-like family; Region: Agmatinase-like; cd09990
1185652008353	active site
1185652008354	oligomer interface [polypeptide binding]; other site
1185652008355	Mn binding site [ion binding]; other site
1185652008356	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
1185652008357	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1185652008358	Walker A/P-loop; other site
1185652008359	ATP binding site [chemical binding]; other site
1185652008360	Q-loop/lid; other site
1185652008361	ABC transporter signature motif; other site
1185652008362	Walker B; other site
1185652008363	D-loop; other site
1185652008364	H-loop/switch region; other site
1185652008365	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1185652008366	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652008367	dimer interface [polypeptide binding]; other site
1185652008368	conserved gate region; other site
1185652008369	putative PBP binding loops; other site
1185652008370	ABC-ATPase subunit interface; other site
1185652008371	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
1185652008372	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1185652008373	allophanate hydrolase; Provisional; Region: PRK08186
1185652008374	Amidase; Region: Amidase; cl11426
1185652008375	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
1185652008376	Isochorismatase family; Region: Isochorismatase; pfam00857
1185652008377	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1185652008378	catalytic triad [active]
1185652008379	conserved cis-peptide bond; other site
1185652008380	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1185652008381	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652008382	Walker A/P-loop; other site
1185652008383	ATP binding site [chemical binding]; other site
1185652008384	Q-loop/lid; other site
1185652008385	ABC transporter signature motif; other site
1185652008386	Walker B; other site
1185652008387	D-loop; other site
1185652008388	H-loop/switch region; other site
1185652008389	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652008390	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652008391	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1185652008392	TM-ABC transporter signature motif; other site
1185652008393	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1185652008394	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652008395	TM-ABC transporter signature motif; other site
1185652008396	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1185652008397	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
1185652008398	putative ligand binding site [chemical binding]; other site
1185652008399	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1185652008400	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652008401	DNA-binding site [nucleotide binding]; DNA binding site
1185652008402	FCD domain; Region: FCD; pfam07729
1185652008403	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652008404	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652008405	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652008406	dimer interface [polypeptide binding]; other site
1185652008407	conserved gate region; other site
1185652008408	putative PBP binding loops; other site
1185652008409	ABC-ATPase subunit interface; other site
1185652008410	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652008411	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652008412	dimer interface [polypeptide binding]; other site
1185652008413	conserved gate region; other site
1185652008414	putative PBP binding loops; other site
1185652008415	ABC-ATPase subunit interface; other site
1185652008416	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1185652008417	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652008418	Walker A/P-loop; other site
1185652008419	ATP binding site [chemical binding]; other site
1185652008420	Q-loop/lid; other site
1185652008421	ABC transporter signature motif; other site
1185652008422	Walker B; other site
1185652008423	D-loop; other site
1185652008424	H-loop/switch region; other site
1185652008425	TOBE domain; Region: TOBE_2; pfam08402
1185652008426	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1185652008427	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652008428	Walker A/P-loop; other site
1185652008429	ATP binding site [chemical binding]; other site
1185652008430	Q-loop/lid; other site
1185652008431	ABC transporter signature motif; other site
1185652008432	Walker B; other site
1185652008433	D-loop; other site
1185652008434	H-loop/switch region; other site
1185652008435	TOBE domain; Region: TOBE_2; pfam08402
1185652008436	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
1185652008437	dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361
1185652008438	DAK2 domain; Region: Dak2; pfam02734
1185652008439	DAK2 domain; Region: Dak2; cl03685
1185652008440	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
1185652008441	active site
1185652008442	active pocket/dimerization site; other site
1185652008443	phosphorylation site [posttranslational modification]
1185652008444	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1185652008445	dimerization domain swap beta strand [polypeptide binding]; other site
1185652008446	regulatory protein interface [polypeptide binding]; other site
1185652008447	active site
1185652008448	regulatory phosphorylation site [posttranslational modification]; other site
1185652008449	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1185652008450	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1185652008451	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1185652008452	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1185652008453	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1185652008454	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1185652008455	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1185652008456	conserved cys residue [active]
1185652008457	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1185652008458	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652008459	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1185652008460	Sterile alpha motif; Region: SAM; smart00454
1185652008461	SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487
1185652008462	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652008463	cyclase homology domain; Region: CHD; cd07302
1185652008464	nucleotidyl binding site; other site
1185652008465	metal binding site [ion binding]; metal-binding site
1185652008466	dimer interface [polypeptide binding]; other site
1185652008467	AAA ATPase domain; Region: AAA_16; pfam13191
1185652008468	Predicted ATPase [General function prediction only]; Region: COG3903
1185652008469	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1185652008470	active site
1185652008471	DNA binding site [nucleotide binding]
1185652008472	Int/Topo IB signature motif; other site
1185652008473	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1185652008474	Serine hydrolase (FSH1); Region: FSH1; pfam03959
1185652008475	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1185652008476	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1185652008477	ligand binding site [chemical binding]; other site
1185652008478	flexible hinge region; other site
1185652008479	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1185652008480	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1185652008481	MULE transposase domain; Region: MULE; pfam10551
1185652008482	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1185652008483	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1185652008484	PilZ domain; Region: PilZ; cl01260
1185652008485	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3828
1185652008486	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1185652008487	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652008488	DNA-binding site [nucleotide binding]; DNA binding site
1185652008489	FCD domain; Region: FCD; pfam07729
1185652008490	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1185652008491	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1185652008492	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1185652008493	DctM-like transporters; Region: DctM; pfam06808
1185652008494	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1185652008495	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1185652008496	FAD binding domain; Region: FAD_binding_4; pfam01565
1185652008497	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1185652008498	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1185652008499	inhibitor site; inhibition site
1185652008500	active site
1185652008501	dimer interface [polypeptide binding]; other site
1185652008502	catalytic residue [active]
1185652008503	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1185652008504	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652008505	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652008506	putative substrate translocation pore; other site
1185652008507	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1185652008508	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652008509	cyclase homology domain; Region: CHD; cd07302
1185652008510	nucleotidyl binding site; other site
1185652008511	metal binding site [ion binding]; metal-binding site
1185652008512	dimer interface [polypeptide binding]; other site
1185652008513	Predicted integral membrane protein [Function unknown]; Region: COG5616
1185652008514	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652008515	TPR motif; other site
1185652008516	TPR repeat; Region: TPR_11; pfam13414
1185652008517	binding surface
1185652008518	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652008519	binding surface
1185652008520	TPR motif; other site
1185652008521	transcriptional regulator NanR; Provisional; Region: PRK03837
1185652008522	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652008523	DNA-binding site [nucleotide binding]; DNA binding site
1185652008524	FCD domain; Region: FCD; pfam07729
1185652008525	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1185652008526	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1185652008527	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1185652008528	DctM-like transporters; Region: DctM; pfam06808
1185652008529	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1185652008530	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1185652008531	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1185652008532	inhibitor site; inhibition site
1185652008533	active site
1185652008534	dimer interface [polypeptide binding]; other site
1185652008535	catalytic residue [active]
1185652008536	N-acetylneuraminate lyase; Provisional; Region: PRK04147
1185652008537	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
1185652008538	inhibitor site; inhibition site
1185652008539	active site
1185652008540	dimer interface [polypeptide binding]; other site
1185652008541	catalytic residue [active]
1185652008542	OsmC-like protein; Region: OsmC; cl00767
1185652008543	Uncharacterized conserved protein [Function unknown]; Region: COG5397
1185652008544	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1185652008545	Staphylococcal nuclease homologues; Region: SNc; smart00318
1185652008546	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1185652008547	Catalytic site; other site
1185652008548	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1185652008549	DNA binding site [nucleotide binding]
1185652008550	active site
1185652008551	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1185652008552	DNA binding site [nucleotide binding]
1185652008553	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1185652008554	Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305
1185652008555	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1185652008556	Walker A motif; other site
1185652008557	ATP binding site [chemical binding]; other site
1185652008558	Walker B motif; other site
1185652008559	Protein of unknown function (DUF982); Region: DUF982; pfam06169
1185652008560	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652008561	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1185652008562	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
1185652008563	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
1185652008564	active site
1185652008565	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1185652008566	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
1185652008567	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
1185652008568	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1185652008569	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015
1185652008570	ATP-dependent DNA ligase [DNA replication, recombination, and repair]; Region: CDC9; COG1793
1185652008571	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1185652008572	MULE transposase domain; Region: MULE; pfam10551
1185652008573	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1185652008574	BA14K-like protein; Region: BA14K; pfam07886
1185652008575	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
1185652008576	active site
1185652008577	catalytic residues [active]
1185652008578	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652008579	non-specific DNA binding site [nucleotide binding]; other site
1185652008580	salt bridge; other site
1185652008581	sequence-specific DNA binding site [nucleotide binding]; other site
1185652008582	HipA N-terminal domain; Region: Couple_hipA; pfam13657
1185652008583	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
1185652008584	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1185652008585	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1185652008586	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
1185652008587	Uncharacterized conserved protein [Function unknown]; Region: COG5654
1185652008588	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
1185652008589	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1185652008590	oligomeric interface; other site
1185652008591	putative active site [active]
1185652008592	homodimer interface [polypeptide binding]; other site
1185652008593	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
1185652008594	Caspase domain; Region: Peptidase_C14; pfam00656
1185652008595	substrate pocket [chemical binding]; other site
1185652008596	active site
1185652008597	dimer interface [polypeptide binding]; other site
1185652008598	proteolytic cleavage site; other site
1185652008599	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
1185652008600	ligand binding surface [chemical binding]; other site
1185652008601	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1185652008602	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
1185652008603	CHASE2 domain; Region: CHASE2; pfam05226
1185652008604	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652008605	cyclase homology domain; Region: CHD; cd07302
1185652008606	nucleotidyl binding site; other site
1185652008607	metal binding site [ion binding]; metal-binding site
1185652008608	dimer interface [polypeptide binding]; other site
1185652008609	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
1185652008610	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1185652008611	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1185652008612	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1185652008613	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
1185652008614	Caspase domain; Region: Peptidase_C14; pfam00656
1185652008615	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1185652008616	Sel1-like repeats; Region: SEL1; smart00671
1185652008617	Sel1-like repeats; Region: SEL1; smart00671
1185652008618	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
1185652008619	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1185652008620	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1185652008621	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
1185652008622	conserved hypothetical protein; Region: TIGR02270
1185652008623	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
1185652008624	3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147
1185652008625	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1185652008626	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212
1185652008627	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867
1185652008628	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
1185652008629	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1185652008630	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1185652008631	hypothetical protein; Provisional; Region: PRK07033
1185652008632	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
1185652008633	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1185652008634	ligand binding site [chemical binding]; other site
1185652008635	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
1185652008636	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
1185652008637	Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405
1185652008638	Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular    transport; Signal transduction mechanisms]; Region: COG3456
1185652008639	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1185652008640	phosphopeptide binding site; other site
1185652008641	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
1185652008642	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
1185652008643	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
1185652008644	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
1185652008645	Protein of unknown function (DUF796); Region: DUF796; cl01226
1185652008646	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
1185652008647	Protein of unknown function (DUF877); Region: DUF877; pfam05943
1185652008648	Protein of unknown function (DUF770); Region: DUF770; cl01402
1185652008649	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
1185652008650	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
1185652008651	Protein kinase domain; Region: Pkinase; pfam00069
1185652008652	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1185652008653	active site
1185652008654	ATP binding site [chemical binding]; other site
1185652008655	substrate binding site [chemical binding]; other site
1185652008656	activation loop (A-loop); other site
1185652008657	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
1185652008658	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652008659	Walker A motif; other site
1185652008660	ATP binding site [chemical binding]; other site
1185652008661	Walker B motif; other site
1185652008662	arginine finger; other site
1185652008663	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652008664	Walker A motif; other site
1185652008665	ATP binding site [chemical binding]; other site
1185652008666	Walker B motif; other site
1185652008667	arginine finger; other site
1185652008668	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1185652008669	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1185652008670	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1185652008671	ligand binding site [chemical binding]; other site
1185652008672	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1185652008673	Protein phosphatase 2C; Region: PP2C; pfam00481
1185652008674	active site
1185652008675	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
1185652008676	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370
1185652008677	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1185652008678	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1185652008679	Predicted transcriptional regulator [Transcription]; Region: COG4957
1185652008680	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1185652008681	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1185652008682	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
1185652008683	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1185652008684	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
1185652008685	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
1185652008686	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1185652008687	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
1185652008688	active site
1185652008689	substrate binding site [chemical binding]; other site
1185652008690	metal binding site [ion binding]; metal-binding site
1185652008691	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1185652008692	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1185652008693	Substrate binding site; other site
1185652008694	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
1185652008695	KpsF/GutQ family protein; Region: kpsF; TIGR00393
1185652008696	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1185652008697	putative active site [active]
1185652008698	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1185652008699	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524
1185652008700	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1185652008701	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1185652008702	Walker A/P-loop; other site
1185652008703	ATP binding site [chemical binding]; other site
1185652008704	Q-loop/lid; other site
1185652008705	ABC transporter signature motif; other site
1185652008706	Walker B; other site
1185652008707	D-loop; other site
1185652008708	H-loop/switch region; other site
1185652008709	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1185652008710	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1185652008711	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
1185652008712	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1185652008713	active site
1185652008714	NTP binding site [chemical binding]; other site
1185652008715	metal binding triad [ion binding]; metal-binding site
1185652008716	antibiotic binding site [chemical binding]; other site
1185652008717	Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748
1185652008718	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1185652008719	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1185652008720	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1185652008721	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
1185652008722	DNA binding residues [nucleotide binding]
1185652008723	dimerization interface [polypeptide binding]; other site
1185652008724	yecA family protein; Region: ygfB_yecA; TIGR02292
1185652008725	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1185652008726	oligomeric interface; other site
1185652008727	putative active site [active]
1185652008728	homodimer interface [polypeptide binding]; other site
1185652008729	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1185652008730	Homeodomain-like domain; Region: HTH_23; pfam13384
1185652008731	Winged helix-turn helix; Region: HTH_29; pfam13551
1185652008732	Homeodomain-like domain; Region: HTH_32; pfam13565
1185652008733	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1185652008734	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
1185652008735	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652008736	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1185652008737	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
1185652008738	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
1185652008739	Staphylococcal nuclease homologues; Region: SNc; smart00318
1185652008740	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1185652008741	Catalytic site; other site
1185652008742	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
1185652008743	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1185652008744	active site
1185652008745	DNA binding site [nucleotide binding]
1185652008746	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1185652008747	DNA binding site [nucleotide binding]
1185652008748	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1185652008749	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652008750	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1185652008751	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652008752	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1185652008753	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1185652008754	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652008755	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1185652008756	Transposase; Region: HTH_Tnp_1; pfam01527
1185652008757	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652008758	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652008759	xylulokinase; Region: PLN02669
1185652008760	Fic family protein [Function unknown]; Region: COG3177
1185652008761	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
1185652008762	Fic/DOC family; Region: Fic; pfam02661
1185652008763	MarR family; Region: MarR_2; cl17246
1185652008764	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1185652008765	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
1185652008766	Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702
1185652008767	Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451
1185652008768	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
1185652008769	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
1185652008770	Type IV secretion system proteins; Region: T4SS; pfam07996
1185652008771	Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704
1185652008772	Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736
1185652008773	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
1185652008774	VirB7 interaction site; other site
1185652008775	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
1185652008776	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
1185652008777	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1185652008778	ATP binding site [chemical binding]; other site
1185652008779	Walker A motif; other site
1185652008780	hexamer interface [polypeptide binding]; other site
1185652008781	Walker B motif; other site
1185652008782	ParB-like nuclease domain; Region: ParBc; pfam02195
1185652008783	Protein of unknown function (DUF1173); Region: DUF1173; pfam06666
1185652008784	Toprim domain; Region: Toprim_3; pfam13362
1185652008785	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
1185652008786	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
1185652008787	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1185652008788	oligomeric interface; other site
1185652008789	putative active site [active]
1185652008790	homodimer interface [polypeptide binding]; other site
1185652008791	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
1185652008792	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1185652008793	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1185652008794	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1185652008795	putative active site [active]
1185652008796	Uncharacterized conserved protein [Function unknown]; Region: COG5489
1185652008797	conjugal transfer coupling protein TraG; Provisional; Region: PRK13822
1185652008798	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
1185652008799	Walker A motif; other site
1185652008800	ATP binding site [chemical binding]; other site
1185652008801	Walker B motif; other site
1185652008802	Conjugal transfer protein TraD; Region: TraD; pfam06412
1185652008803	TraC-like protein; Region: TraC; pfam07820
1185652008804	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
1185652008805	MobA/MobL family; Region: MobA_MobL; pfam03389
1185652008806	AAA domain; Region: AAA_30; pfam13604
1185652008807	Family description; Region: UvrD_C_2; pfam13538
1185652008808	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1185652008809	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652008810	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1185652008811	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652008812	dimer interface [polypeptide binding]; other site
1185652008813	conserved gate region; other site
1185652008814	putative PBP binding loops; other site
1185652008815	ABC-ATPase subunit interface; other site
1185652008816	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1185652008817	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652008818	dimer interface [polypeptide binding]; other site
1185652008819	conserved gate region; other site
1185652008820	putative PBP binding loops; other site
1185652008821	ABC-ATPase subunit interface; other site
1185652008822	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1185652008823	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652008824	Walker A/P-loop; other site
1185652008825	ATP binding site [chemical binding]; other site
1185652008826	Q-loop/lid; other site
1185652008827	ABC transporter signature motif; other site
1185652008828	Walker B; other site
1185652008829	D-loop; other site
1185652008830	H-loop/switch region; other site
1185652008831	TOBE domain; Region: TOBE_2; pfam08402
1185652008832	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1185652008833	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652008834	DNA-binding site [nucleotide binding]; DNA binding site
1185652008835	FCD domain; Region: FCD; pfam07729
1185652008836	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
1185652008837	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1185652008838	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1185652008839	catalytic residue [active]
1185652008840	acetolactate synthase catalytic subunit; Validated; Region: PRK06112
1185652008841	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1185652008842	PYR/PP interface [polypeptide binding]; other site
1185652008843	dimer interface [polypeptide binding]; other site
1185652008844	TPP binding site [chemical binding]; other site
1185652008845	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1185652008846	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1185652008847	TPP-binding site [chemical binding]; other site
1185652008848	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
1185652008849	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652008850	NAD(P) binding site [chemical binding]; other site
1185652008851	active site
1185652008852	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652008853	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1185652008854	active site
1185652008855	phosphorylation site [posttranslational modification]
1185652008856	intermolecular recognition site; other site
1185652008857	dimerization interface [polypeptide binding]; other site
1185652008858	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652008859	DNA binding site [nucleotide binding]
1185652008860	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652008861	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1185652008862	active site
1185652008863	phosphorylation site [posttranslational modification]
1185652008864	intermolecular recognition site; other site
1185652008865	dimerization interface [polypeptide binding]; other site
1185652008866	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652008867	DNA binding site [nucleotide binding]
1185652008868	hypothetical protein; Provisional; Region: PRK07505
1185652008869	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
1185652008870	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1185652008871	catalytic residue [active]
1185652008872	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
1185652008873	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1185652008874	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
1185652008875	Walker A/P-loop; other site
1185652008876	ATP binding site [chemical binding]; other site
1185652008877	Q-loop/lid; other site
1185652008878	ABC transporter signature motif; other site
1185652008879	Walker B; other site
1185652008880	D-loop; other site
1185652008881	H-loop/switch region; other site
1185652008882	HlyD family secretion protein; Region: HlyD; pfam00529
1185652008883	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1185652008884	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652008885	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652008886	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1185652008887	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652008888	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652008889	putative DNA binding site [nucleotide binding]; other site
1185652008890	putative Zn2+ binding site [ion binding]; other site
1185652008891	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652008892	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1185652008893	DNA-binding site [nucleotide binding]; DNA binding site
1185652008894	RNA-binding motif; other site
1185652008895	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1185652008896	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
1185652008897	putative di-iron ligands [ion binding]; other site
1185652008898	MarR family; Region: MarR_2; pfam12802
1185652008899	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1185652008900	Walker A motif; other site
1185652008901	ATP binding site [chemical binding]; other site
1185652008902	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
1185652008903	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1185652008904	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1185652008905	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1185652008906	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1185652008907	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1185652008908	ATP binding site [chemical binding]; other site
1185652008909	Walker A motif; other site
1185652008910	hexamer interface [polypeptide binding]; other site
1185652008911	Walker B motif; other site
1185652008912	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1185652008913	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1185652008914	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1185652008915	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1185652008916	active site
1185652008917	phosphorylation site [posttranslational modification]
1185652008918	dimerization interface [polypeptide binding]; other site
1185652008919	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
1185652008920	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1185652008921	TadE-like protein; Region: TadE; pfam07811
1185652008922	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1185652008923	TadE-like protein; Region: TadE; pfam07811
1185652008924	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1185652008925	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
1185652008926	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
1185652008927	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
1185652008928	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1185652008929	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
1185652008930	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1185652008931	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1185652008932	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652008933	Walker A/P-loop; other site
1185652008934	ATP binding site [chemical binding]; other site
1185652008935	Q-loop/lid; other site
1185652008936	ABC transporter signature motif; other site
1185652008937	Walker B; other site
1185652008938	D-loop; other site
1185652008939	H-loop/switch region; other site
1185652008940	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652008941	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652008942	Walker A/P-loop; other site
1185652008943	ATP binding site [chemical binding]; other site
1185652008944	Q-loop/lid; other site
1185652008945	ABC transporter signature motif; other site
1185652008946	Walker B; other site
1185652008947	D-loop; other site
1185652008948	H-loop/switch region; other site
1185652008949	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652008950	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1185652008951	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652008952	dimer interface [polypeptide binding]; other site
1185652008953	conserved gate region; other site
1185652008954	ABC-ATPase subunit interface; other site
1185652008955	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1185652008956	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652008957	dimer interface [polypeptide binding]; other site
1185652008958	conserved gate region; other site
1185652008959	putative PBP binding loops; other site
1185652008960	ABC-ATPase subunit interface; other site
1185652008961	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1185652008962	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
1185652008963	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1185652008964	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
1185652008965	hypothetical protein; Provisional; Region: PRK05965
1185652008966	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1185652008967	inhibitor-cofactor binding pocket; inhibition site
1185652008968	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652008969	catalytic residue [active]
1185652008970	putative acetyltransferase; Provisional; Region: PRK03624
1185652008971	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652008972	Coenzyme A binding pocket [chemical binding]; other site
1185652008973	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1185652008974	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
1185652008975	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1185652008976	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652008977	transcriptional regulator; Provisional; Region: PRK10632
1185652008978	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652008979	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
1185652008980	putative effector binding pocket; other site
1185652008981	putative dimerization interface [polypeptide binding]; other site
1185652008982	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1185652008983	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
1185652008984	putative C-terminal domain interface [polypeptide binding]; other site
1185652008985	putative GSH binding site (G-site) [chemical binding]; other site
1185652008986	putative dimer interface [polypeptide binding]; other site
1185652008987	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
1185652008988	putative N-terminal domain interface [polypeptide binding]; other site
1185652008989	putative dimer interface [polypeptide binding]; other site
1185652008990	putative substrate binding pocket (H-site) [chemical binding]; other site
1185652008991	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1185652008992	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1185652008993	succinic semialdehyde dehydrogenase; Region: PLN02278
1185652008994	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1185652008995	tetramerization interface [polypeptide binding]; other site
1185652008996	NAD(P) binding site [chemical binding]; other site
1185652008997	catalytic residues [active]
1185652008998	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
1185652008999	tartrate dehydrogenase; Region: TTC; TIGR02089
1185652009000	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1185652009001	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1185652009002	NAD(P) binding site [chemical binding]; other site
1185652009003	catalytic residues [active]
1185652009004	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
1185652009005	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652009006	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
1185652009007	putative dimerization interface [polypeptide binding]; other site
1185652009008	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1185652009009	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
1185652009010	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1185652009011	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1185652009012	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1185652009013	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1185652009014	Coenzyme A binding pocket [chemical binding]; other site
1185652009015	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
1185652009016	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
1185652009017	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1185652009018	putative ligand binding site [chemical binding]; other site
1185652009019	NAD binding site [chemical binding]; other site
1185652009020	dimerization interface [polypeptide binding]; other site
1185652009021	catalytic site [active]
1185652009022	acetylornithine deacetylase; Provisional; Region: PRK07522
1185652009023	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
1185652009024	metal binding site [ion binding]; metal-binding site
1185652009025	putative dimer interface [polypeptide binding]; other site
1185652009026	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652009027	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1185652009028	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1185652009029	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1185652009030	DNA binding site [nucleotide binding]
1185652009031	active site
1185652009032	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652009033	cyclase homology domain; Region: CHD; cd07302
1185652009034	nucleotidyl binding site; other site
1185652009035	metal binding site [ion binding]; metal-binding site
1185652009036	dimer interface [polypeptide binding]; other site
1185652009037	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
1185652009038	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652009039	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652009040	metal binding site [ion binding]; metal-binding site
1185652009041	active site
1185652009042	I-site; other site
1185652009043	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652009044	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1185652009045	putative active site [active]
1185652009046	heme pocket [chemical binding]; other site
1185652009047	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1185652009048	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652009049	putative active site [active]
1185652009050	heme pocket [chemical binding]; other site
1185652009051	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652009052	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1185652009053	putative active site [active]
1185652009054	heme pocket [chemical binding]; other site
1185652009055	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652009056	putative active site [active]
1185652009057	heme pocket [chemical binding]; other site
1185652009058	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652009059	PAS domain; Region: PAS_9; pfam13426
1185652009060	putative active site [active]
1185652009061	heme pocket [chemical binding]; other site
1185652009062	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652009063	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652009064	metal binding site [ion binding]; metal-binding site
1185652009065	active site
1185652009066	I-site; other site
1185652009067	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1185652009068	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652009069	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652009070	active site
1185652009071	phosphorylation site [posttranslational modification]
1185652009072	intermolecular recognition site; other site
1185652009073	dimerization interface [polypeptide binding]; other site
1185652009074	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652009075	DNA binding residues [nucleotide binding]
1185652009076	dimerization interface [polypeptide binding]; other site
1185652009077	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1185652009078	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1185652009079	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1185652009080	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1185652009081	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1185652009082	dimerization interface [polypeptide binding]; other site
1185652009083	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1185652009084	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1185652009085	dimer interface [polypeptide binding]; other site
1185652009086	putative CheW interface [polypeptide binding]; other site
1185652009087	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1185652009088	putative binding surface; other site
1185652009089	active site
1185652009090	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652009091	ATP binding site [chemical binding]; other site
1185652009092	Mg2+ binding site [ion binding]; other site
1185652009093	G-X-G motif; other site
1185652009094	CheW-like domain; Region: CheW; pfam01584
1185652009095	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1185652009096	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652009097	active site
1185652009098	phosphorylation site [posttranslational modification]
1185652009099	intermolecular recognition site; other site
1185652009100	dimerization interface [polypeptide binding]; other site
1185652009101	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
1185652009102	CheB methylesterase; Region: CheB_methylest; pfam01339
1185652009103	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
1185652009104	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1185652009105	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1185652009106	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1185652009107	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1185652009108	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1185652009109	ATP binding site [chemical binding]; other site
1185652009110	Walker A motif; other site
1185652009111	hexamer interface [polypeptide binding]; other site
1185652009112	Walker B motif; other site
1185652009113	Flp/Fap pilin component; Region: Flp_Fap; cl01585
1185652009114	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
1185652009115	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1185652009116	TadE-like protein; Region: TadE; pfam07811
1185652009117	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
1185652009118	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1185652009119	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1185652009120	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1185652009121	TadE-like protein; Region: TadE; pfam07811
1185652009122	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
1185652009123	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1185652009124	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
1185652009125	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
1185652009126	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1185652009127	PRC-barrel domain; Region: PRC; pfam05239
1185652009128	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1185652009129	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1185652009130	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1185652009131	EamA-like transporter family; Region: EamA; pfam00892
1185652009132	glycogen synthase; Provisional; Region: glgA; PRK00654
1185652009133	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1185652009134	ADP-binding pocket [chemical binding]; other site
1185652009135	homodimer interface [polypeptide binding]; other site
1185652009136	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1185652009137	substrate binding site [chemical binding]; other site
1185652009138	hydroperoxidase II; Provisional; Region: katE; PRK11249
1185652009139	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
1185652009140	tetramer interface [polypeptide binding]; other site
1185652009141	heme binding pocket [chemical binding]; other site
1185652009142	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
1185652009143	domain interactions; other site
1185652009144	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
1185652009145	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
1185652009146	active site
1185652009147	DNA binding site [nucleotide binding]
1185652009148	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
1185652009149	DNA binding site [nucleotide binding]
1185652009150	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1185652009151	active site
1185652009152	DNA binding site [nucleotide binding]
1185652009153	Protein of unknown function (DUF763); Region: DUF763; pfam05559
1185652009154	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
1185652009155	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
1185652009156	glutathione s-transferase; Provisional; Region: PTZ00057
1185652009157	GSH binding site (G-site) [chemical binding]; other site
1185652009158	C-terminal domain interface [polypeptide binding]; other site
1185652009159	dimer interface [polypeptide binding]; other site
1185652009160	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
1185652009161	dimer interface [polypeptide binding]; other site
1185652009162	N-terminal domain interface [polypeptide binding]; other site
1185652009163	substrate binding pocket (H-site) [chemical binding]; other site
1185652009164	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1185652009165	Fe-S cluster binding site [ion binding]; other site
1185652009166	active site
1185652009167	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
1185652009168	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
1185652009169	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
1185652009170	catalytic site [active]
1185652009171	active site
1185652009172	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1185652009173	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1185652009174	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1185652009175	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1185652009176	active site
1185652009177	catalytic site [active]
1185652009178	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
1185652009179	FOG: CBS domain [General function prediction only]; Region: COG0517
1185652009180	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
1185652009181	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
1185652009182	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1185652009183	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652009184	S-adenosylmethionine binding site [chemical binding]; other site
1185652009185	FtsJ-like methyltransferase; Region: FtsJ; cl17430
1185652009186	ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048
1185652009187	Periplasmic binding protein TroA_f.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139
1185652009188	putative ligand binding residues [chemical binding]; other site
1185652009189	Periplasmic binding protein TroA_f.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139
1185652009190	ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048
1185652009191	putative ligand binding residues [chemical binding]; other site
1185652009192	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1185652009193	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1185652009194	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1185652009195	ABC-ATPase subunit  interface; other site
1185652009196	dimer interface [polypeptide binding]; other site
1185652009197	putative PBP binding regions; other site
1185652009198	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1185652009199	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1185652009200	Walker A/P-loop; other site
1185652009201	ATP binding site [chemical binding]; other site
1185652009202	Q-loop/lid; other site
1185652009203	ABC transporter signature motif; other site
1185652009204	Walker B; other site
1185652009205	D-loop; other site
1185652009206	H-loop/switch region; other site
1185652009207	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1185652009208	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652009209	Walker A/P-loop; other site
1185652009210	ATP binding site [chemical binding]; other site
1185652009211	Q-loop/lid; other site
1185652009212	ABC transporter signature motif; other site
1185652009213	Walker B; other site
1185652009214	D-loop; other site
1185652009215	H-loop/switch region; other site
1185652009216	TOBE domain; Region: TOBE_2; pfam08402
1185652009217	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1185652009218	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1185652009219	substrate binding [chemical binding]; other site
1185652009220	active site
1185652009221	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1185652009222	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652009223	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652009224	dimer interface [polypeptide binding]; other site
1185652009225	conserved gate region; other site
1185652009226	putative PBP binding loops; other site
1185652009227	ABC-ATPase subunit interface; other site
1185652009228	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652009229	dimer interface [polypeptide binding]; other site
1185652009230	conserved gate region; other site
1185652009231	putative PBP binding loops; other site
1185652009232	ABC-ATPase subunit interface; other site
1185652009233	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652009234	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652009235	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652009236	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652009237	DNA binding site [nucleotide binding]
1185652009238	domain linker motif; other site
1185652009239	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
1185652009240	putative dimerization interface [polypeptide binding]; other site
1185652009241	putative ligand binding site [chemical binding]; other site
1185652009242	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
1185652009243	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
1185652009244	dimer interface [polypeptide binding]; other site
1185652009245	active site residues [active]
1185652009246	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
1185652009247	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1185652009248	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1185652009249	Helix-turn-helix domain; Region: HTH_28; pfam13518
1185652009250	Winged helix-turn helix; Region: HTH_29; pfam13551
1185652009251	Homeodomain-like domain; Region: HTH_32; pfam13565
1185652009252	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1185652009253	Integrase core domain; Region: rve; pfam00665
1185652009254	Integrase core domain; Region: rve_3; pfam13683
1185652009255	MULE transposase domain; Region: MULE; pfam10551
1185652009256	Uncharacterized conserved protein (DUF2280); Region: DUF2280; cl02353
1185652009257	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566
1185652009258	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
1185652009259	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834
1185652009260	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1185652009261	nudix motif; other site
1185652009262	siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470
1185652009263	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1185652009264	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
1185652009265	Uroporphyrinogen-III methylase [Coenzyme metabolism]; Region: CysG; COG0007
1185652009266	homodimer interface [polypeptide binding]; other site
1185652009267	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1185652009268	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1185652009269	[4Fe-4S] binding site [ion binding]; other site
1185652009270	molybdopterin cofactor binding site; other site
1185652009271	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1185652009272	molybdopterin cofactor binding site; other site
1185652009273	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1185652009274	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
1185652009275	[2Fe-2S] cluster binding site [ion binding]; other site
1185652009276	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
1185652009277	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652009278	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1185652009279	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1185652009280	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1185652009281	NMT1-like family; Region: NMT1_2; pfam13379
1185652009282	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1185652009283	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
1185652009284	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652009285	active site
1185652009286	phosphorylation site [posttranslational modification]
1185652009287	intermolecular recognition site; other site
1185652009288	ANTAR domain; Region: ANTAR; pfam03861
1185652009289	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652009290	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652009291	active site
1185652009292	phosphorylation site [posttranslational modification]
1185652009293	intermolecular recognition site; other site
1185652009294	dimerization interface [polypeptide binding]; other site
1185652009295	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652009296	DNA binding residues [nucleotide binding]
1185652009297	dimerization interface [polypeptide binding]; other site
1185652009298	Uncharacterized conserved protein [Function unknown]; Region: COG3287
1185652009299	FIST N domain; Region: FIST; pfam08495
1185652009300	FIST C domain; Region: FIST_C; pfam10442
1185652009301	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652009302	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652009303	dimer interface [polypeptide binding]; other site
1185652009304	phosphorylation site [posttranslational modification]
1185652009305	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652009306	ATP binding site [chemical binding]; other site
1185652009307	Mg2+ binding site [ion binding]; other site
1185652009308	G-X-G motif; other site
1185652009309	Response regulator receiver domain; Region: Response_reg; pfam00072
1185652009310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652009311	active site
1185652009312	phosphorylation site [posttranslational modification]
1185652009313	intermolecular recognition site; other site
1185652009314	dimerization interface [polypeptide binding]; other site
1185652009315	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1185652009316	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1185652009317	substrate binding site [chemical binding]; other site
1185652009318	catalytic Zn binding site [ion binding]; other site
1185652009319	NAD binding site [chemical binding]; other site
1185652009320	structural Zn binding site [ion binding]; other site
1185652009321	dimer interface [polypeptide binding]; other site
1185652009322	S-formylglutathione hydrolase; Region: PLN02442
1185652009323	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
1185652009324	Cytochrome c2 [Energy production and conversion]; Region: COG3474
1185652009325	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
1185652009326	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
1185652009327	Trp docking motif [polypeptide binding]; other site
1185652009328	dimer interface [polypeptide binding]; other site
1185652009329	active site
1185652009330	small subunit binding site [polypeptide binding]; other site
1185652009331	c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874
1185652009332	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1185652009333	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
1185652009334	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652009335	substrate binding pocket [chemical binding]; other site
1185652009336	membrane-bound complex binding site; other site
1185652009337	hinge residues; other site
1185652009338	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
1185652009339	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1185652009340	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1185652009341	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1185652009342	putative hydrophobic ligand binding site [chemical binding]; other site
1185652009343	protein interface [polypeptide binding]; other site
1185652009344	gate; other site
1185652009345	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
1185652009346	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
1185652009347	ligand binding site [chemical binding]; other site
1185652009348	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
1185652009349	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1185652009350	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1185652009351	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1185652009352	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1185652009353	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1185652009354	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652009355	dimer interface [polypeptide binding]; other site
1185652009356	conserved gate region; other site
1185652009357	putative PBP binding loops; other site
1185652009358	ABC-ATPase subunit interface; other site
1185652009359	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1185652009360	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652009361	Walker A/P-loop; other site
1185652009362	ATP binding site [chemical binding]; other site
1185652009363	Q-loop/lid; other site
1185652009364	ABC transporter signature motif; other site
1185652009365	Walker B; other site
1185652009366	D-loop; other site
1185652009367	H-loop/switch region; other site
1185652009368	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
1185652009369	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652009370	Walker A/P-loop; other site
1185652009371	ATP binding site [chemical binding]; other site
1185652009372	Q-loop/lid; other site
1185652009373	ABC transporter signature motif; other site
1185652009374	Walker B; other site
1185652009375	D-loop; other site
1185652009376	H-loop/switch region; other site
1185652009377	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1185652009378	alcohol ABC transporter, permease protein; Region: phenyl_ABC_PedC; TIGR03861
1185652009379	glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417
1185652009380	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
1185652009381	putative catalytic residue [active]
1185652009382	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1185652009383	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1185652009384	substrate binding site [chemical binding]; other site
1185652009385	hexamer interface [polypeptide binding]; other site
1185652009386	metal binding site [ion binding]; metal-binding site
1185652009387	probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880
1185652009388	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652009389	Walker A motif; other site
1185652009390	ATP binding site [chemical binding]; other site
1185652009391	Walker B motif; other site
1185652009392	arginine finger; other site
1185652009393	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
1185652009394	multimerization interface [polypeptide binding]; other site
1185652009395	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
1185652009396	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
1185652009397	homodimer interface [polypeptide binding]; other site
1185652009398	active site
1185652009399	heterodimer interface [polypeptide binding]; other site
1185652009400	catalytic residue [active]
1185652009401	metal binding site [ion binding]; metal-binding site
1185652009402	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1185652009403	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1185652009404	intersubunit interface [polypeptide binding]; other site
1185652009405	active site
1185652009406	zinc binding site [ion binding]; other site
1185652009407	Na+ binding site [ion binding]; other site
1185652009408	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1185652009409	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1185652009410	TPP-binding site [chemical binding]; other site
1185652009411	dimer interface [polypeptide binding]; other site
1185652009412	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1185652009413	PYR/PP interface [polypeptide binding]; other site
1185652009414	dimer interface [polypeptide binding]; other site
1185652009415	TPP binding site [chemical binding]; other site
1185652009416	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1185652009417	phosphoribulokinase; Provisional; Region: PRK15453
1185652009418	fructose-1,6-bisphosphatase family protein; Region: PLN02628
1185652009419	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1185652009420	AMP binding site [chemical binding]; other site
1185652009421	metal binding site [ion binding]; metal-binding site
1185652009422	active site
1185652009423	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652009424	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652009425	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
1185652009426	putative dimerization interface [polypeptide binding]; other site
1185652009427	PqqA family; Region: PqqA; pfam08042
1185652009428	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
1185652009429	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
1185652009430	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
1185652009431	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
1185652009432	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
1185652009433	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1185652009434	FeS/SAM binding site; other site
1185652009435	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1185652009436	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274
1185652009437	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1185652009438	putative NAD(P) binding site [chemical binding]; other site
1185652009439	hypothetical protein; Provisional; Region: PRK07482
1185652009440	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1185652009441	inhibitor-cofactor binding pocket; inhibition site
1185652009442	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652009443	catalytic residue [active]
1185652009444	succinic semialdehyde dehydrogenase; Region: PLN02278
1185652009445	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1185652009446	tetramerization interface [polypeptide binding]; other site
1185652009447	NAD(P) binding site [chemical binding]; other site
1185652009448	catalytic residues [active]
1185652009449	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652009450	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652009451	putative DNA binding site [nucleotide binding]; other site
1185652009452	putative Zn2+ binding site [ion binding]; other site
1185652009453	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652009454	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1185652009455	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652009456	DNA-binding site [nucleotide binding]; DNA binding site
1185652009457	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652009458	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652009459	homodimer interface [polypeptide binding]; other site
1185652009460	catalytic residue [active]
1185652009461	ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005
1185652009462	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1185652009463	Walker A/P-loop; other site
1185652009464	ATP binding site [chemical binding]; other site
1185652009465	Q-loop/lid; other site
1185652009466	ABC transporter signature motif; other site
1185652009467	Walker B; other site
1185652009468	D-loop; other site
1185652009469	H-loop/switch region; other site
1185652009470	ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995
1185652009471	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652009472	substrate binding pocket [chemical binding]; other site
1185652009473	membrane-bound complex binding site; other site
1185652009474	hinge residues; other site
1185652009475	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1185652009476	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652009477	dimer interface [polypeptide binding]; other site
1185652009478	conserved gate region; other site
1185652009479	putative PBP binding loops; other site
1185652009480	ABC-ATPase subunit interface; other site
1185652009481	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652009482	dimer interface [polypeptide binding]; other site
1185652009483	conserved gate region; other site
1185652009484	putative PBP binding loops; other site
1185652009485	ABC-ATPase subunit interface; other site
1185652009486	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1185652009487	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1185652009488	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1185652009489	tetramer interface [polypeptide binding]; other site
1185652009490	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652009491	catalytic residue [active]
1185652009492	ectoine utilization protein EutC; Validated; Region: PRK08291
1185652009493	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1185652009494	ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993
1185652009495	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1185652009496	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1185652009497	active site
1185652009498	ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994
1185652009499	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252
1185652009500	putative active site [active]
1185652009501	Zn binding site [ion binding]; other site
1185652009502	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
1185652009503	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1185652009504	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652009505	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1185652009506	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508
1185652009507	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1185652009508	E3 interaction surface; other site
1185652009509	lipoyl attachment site [posttranslational modification]; other site
1185652009510	e3 binding domain; Region: E3_binding; pfam02817
1185652009511	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1185652009512	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1185652009513	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1185652009514	TPP-binding site [chemical binding]; other site
1185652009515	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1185652009516	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1185652009517	alpha subunit interface [polypeptide binding]; other site
1185652009518	TPP binding site [chemical binding]; other site
1185652009519	heterodimer interface [polypeptide binding]; other site
1185652009520	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1185652009521	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652009522	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1185652009523	putative DNA binding site [nucleotide binding]; other site
1185652009524	putative Zn2+ binding site [ion binding]; other site
1185652009525	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652009526	PaaX-like protein; Region: PaaX; pfam07848
1185652009527	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
1185652009528	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
1185652009529	Uncharacterized conserved protein [Function unknown]; Region: COG3482
1185652009530	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1185652009531	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652009532	non-specific DNA binding site [nucleotide binding]; other site
1185652009533	salt bridge; other site
1185652009534	sequence-specific DNA binding site [nucleotide binding]; other site
1185652009535	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652009536	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
1185652009537	dimerization interface [polypeptide binding]; other site
1185652009538	ligand binding site [chemical binding]; other site
1185652009539	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
1185652009540	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1185652009541	ligand binding site [chemical binding]; other site
1185652009542	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1185652009543	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652009544	Walker A/P-loop; other site
1185652009545	ATP binding site [chemical binding]; other site
1185652009546	Q-loop/lid; other site
1185652009547	ABC transporter signature motif; other site
1185652009548	Walker B; other site
1185652009549	D-loop; other site
1185652009550	H-loop/switch region; other site
1185652009551	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652009552	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652009553	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652009554	TM-ABC transporter signature motif; other site
1185652009555	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652009556	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652009557	TM-ABC transporter signature motif; other site
1185652009558	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1185652009559	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1185652009560	Metal-binding active site; metal-binding site
1185652009561	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1185652009562	Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772
1185652009563	N- and C-terminal domain interface [polypeptide binding]; other site
1185652009564	putative active site [active]
1185652009565	putative MgATP binding site [chemical binding]; other site
1185652009566	putative catalytic site [active]
1185652009567	metal binding site [ion binding]; metal-binding site
1185652009568	putative carbohydrate binding site [chemical binding]; other site
1185652009569	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
1185652009570	intersubunit interface [polypeptide binding]; other site
1185652009571	active site
1185652009572	Zn2+ binding site [ion binding]; other site
1185652009573	isovaleryl-CoA dehydrogenase; Region: PLN02519
1185652009574	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
1185652009575	substrate binding site [chemical binding]; other site
1185652009576	FAD binding site [chemical binding]; other site
1185652009577	catalytic base [active]
1185652009578	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
1185652009579	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1185652009580	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1185652009581	homotrimer interaction site [polypeptide binding]; other site
1185652009582	putative active site [active]
1185652009583	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1185652009584	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1185652009585	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1185652009586	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1185652009587	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1185652009588	carboxyltransferase (CT) interaction site; other site
1185652009589	biotinylation site [posttranslational modification]; other site
1185652009590	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1185652009591	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1185652009592	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1185652009593	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1185652009594	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1185652009595	active site
1185652009596	catalytic residues [active]
1185652009597	metal binding site [ion binding]; metal-binding site
1185652009598	enoyl-CoA hydratase; Provisional; Region: PRK07468
1185652009599	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1185652009600	substrate binding site [chemical binding]; other site
1185652009601	oxyanion hole (OAH) forming residues; other site
1185652009602	trimer interface [polypeptide binding]; other site
1185652009603	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
1185652009604	Uncharacterized conserved protein [Function unknown]; Region: COG5654
1185652009605	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
1185652009606	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
1185652009607	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1185652009608	Walker A/P-loop; other site
1185652009609	ATP binding site [chemical binding]; other site
1185652009610	Q-loop/lid; other site
1185652009611	ABC transporter signature motif; other site
1185652009612	Walker B; other site
1185652009613	D-loop; other site
1185652009614	H-loop/switch region; other site
1185652009615	TOBE-like domain; Region: TOBE_3; pfam12857
1185652009616	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652009617	dimer interface [polypeptide binding]; other site
1185652009618	conserved gate region; other site
1185652009619	putative PBP binding loops; other site
1185652009620	ABC-ATPase subunit interface; other site
1185652009621	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1185652009622	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652009623	dimer interface [polypeptide binding]; other site
1185652009624	conserved gate region; other site
1185652009625	putative PBP binding loops; other site
1185652009626	ABC-ATPase subunit interface; other site
1185652009627	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1185652009628	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652009629	substrate binding pocket [chemical binding]; other site
1185652009630	membrane-bound complex binding site; other site
1185652009631	hinge residues; other site
1185652009632	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1185652009633	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820
1185652009634	dimer interface [polypeptide binding]; other site
1185652009635	active site
1185652009636	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1185652009637	substrate binding site [chemical binding]; other site
1185652009638	catalytic residue [active]
1185652009639	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1185652009640	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652009641	substrate binding pocket [chemical binding]; other site
1185652009642	membrane-bound complex binding site; other site
1185652009643	hinge residues; other site
1185652009644	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652009645	dimer interface [polypeptide binding]; other site
1185652009646	conserved gate region; other site
1185652009647	putative PBP binding loops; other site
1185652009648	ABC-ATPase subunit interface; other site
1185652009649	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652009650	dimer interface [polypeptide binding]; other site
1185652009651	conserved gate region; other site
1185652009652	putative PBP binding loops; other site
1185652009653	ABC-ATPase subunit interface; other site
1185652009654	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1185652009655	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652009656	Walker A/P-loop; other site
1185652009657	ATP binding site [chemical binding]; other site
1185652009658	Q-loop/lid; other site
1185652009659	ABC transporter signature motif; other site
1185652009660	Walker B; other site
1185652009661	D-loop; other site
1185652009662	H-loop/switch region; other site
1185652009663	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1185652009664	homotrimer interaction site [polypeptide binding]; other site
1185652009665	putative active site [active]
1185652009666	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1185652009667	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
1185652009668	Bacterial transcriptional regulator; Region: IclR; pfam01614
1185652009669	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1185652009670	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652009671	Walker A/P-loop; other site
1185652009672	ATP binding site [chemical binding]; other site
1185652009673	Q-loop/lid; other site
1185652009674	ABC transporter signature motif; other site
1185652009675	Walker B; other site
1185652009676	D-loop; other site
1185652009677	H-loop/switch region; other site
1185652009678	TOBE domain; Region: TOBE_2; pfam08402
1185652009679	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1185652009680	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
1185652009681	substrate binding site [chemical binding]; other site
1185652009682	ATP binding site [chemical binding]; other site
1185652009683	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1185652009684	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1185652009685	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652009686	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652009687	dimer interface [polypeptide binding]; other site
1185652009688	conserved gate region; other site
1185652009689	putative PBP binding loops; other site
1185652009690	ABC-ATPase subunit interface; other site
1185652009691	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652009692	dimer interface [polypeptide binding]; other site
1185652009693	conserved gate region; other site
1185652009694	putative PBP binding loops; other site
1185652009695	ABC-ATPase subunit interface; other site
1185652009696	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652009697	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652009698	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1185652009699	non-specific DNA interactions [nucleotide binding]; other site
1185652009700	DNA binding site [nucleotide binding]
1185652009701	sequence specific DNA binding site [nucleotide binding]; other site
1185652009702	putative cAMP binding site [chemical binding]; other site
1185652009703	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1185652009704	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1185652009705	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1185652009706	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1185652009707	Active Sites [active]
1185652009708	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
1185652009709	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1185652009710	CysD dimerization site [polypeptide binding]; other site
1185652009711	G1 box; other site
1185652009712	putative GEF interaction site [polypeptide binding]; other site
1185652009713	GTP/Mg2+ binding site [chemical binding]; other site
1185652009714	Switch I region; other site
1185652009715	G2 box; other site
1185652009716	G3 box; other site
1185652009717	Switch II region; other site
1185652009718	G4 box; other site
1185652009719	G5 box; other site
1185652009720	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1185652009721	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1185652009722	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1185652009723	ligand-binding site [chemical binding]; other site
1185652009724	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1185652009725	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1185652009726	active site
1185652009727	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
1185652009728	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1185652009729	active site
1185652009730	dimer interface [polypeptide binding]; other site
1185652009731	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1185652009732	Ligand Binding Site [chemical binding]; other site
1185652009733	Molecular Tunnel; other site
1185652009734	PHP domain; Region: PHP; pfam02811
1185652009735	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1185652009736	active site
1185652009737	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
1185652009738	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1185652009739	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652009740	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652009741	NAD(P) binding site [chemical binding]; other site
1185652009742	active site
1185652009743	CsbD-like; Region: CsbD; cl17424
1185652009744	Integrase core domain; Region: rve_3; cl15866
1185652009745	PRC-barrel domain; Region: PRC; pfam05239
1185652009746	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
1185652009747	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1185652009748	Homeodomain-like domain; Region: HTH_23; pfam13384
1185652009749	Winged helix-turn helix; Region: HTH_29; pfam13551
1185652009750	Homeodomain-like domain; Region: HTH_32; pfam13565
1185652009751	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1185652009752	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
1185652009753	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
1185652009754	PAS fold; Region: PAS_4; pfam08448
1185652009755	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1185652009756	Histidine kinase; Region: HisKA_2; pfam07568
1185652009757	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652009758	ATP binding site [chemical binding]; other site
1185652009759	Mg2+ binding site [ion binding]; other site
1185652009760	G-X-G motif; other site
1185652009761	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1185652009762	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1185652009763	catalytic residues [active]
1185652009764	catalytic nucleophile [active]
1185652009765	Presynaptic Site I dimer interface [polypeptide binding]; other site
1185652009766	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1185652009767	Synaptic Flat tetramer interface [polypeptide binding]; other site
1185652009768	Synaptic Site I dimer interface [polypeptide binding]; other site
1185652009769	DNA binding site [nucleotide binding]
1185652009770	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1185652009771	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
1185652009772	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
1185652009773	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1185652009774	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1185652009775	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
1185652009776	putative ADP-binding pocket [chemical binding]; other site
1185652009777	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1185652009778	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1185652009779	putative ADP-binding pocket [chemical binding]; other site
1185652009780	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1185652009781	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1185652009782	NAD(P) binding site [chemical binding]; other site
1185652009783	homodimer interface [polypeptide binding]; other site
1185652009784	substrate binding site [chemical binding]; other site
1185652009785	active site
1185652009786	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
1185652009787	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
1185652009788	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
1185652009789	catalytic triad [active]
1185652009790	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652009791	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652009792	active site
1185652009793	phosphorylation site [posttranslational modification]
1185652009794	intermolecular recognition site; other site
1185652009795	dimerization interface [polypeptide binding]; other site
1185652009796	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652009797	DNA binding residues [nucleotide binding]
1185652009798	dimerization interface [polypeptide binding]; other site
1185652009799	Histidine kinase; Region: HisKA_3; pfam07730
1185652009800	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1185652009801	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
1185652009802	Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_4; cd08651
1185652009803	putative active site [active]
1185652009804	putative substrate binding site [chemical binding]; other site
1185652009805	putative cosubstrate binding site; other site
1185652009806	catalytic site [active]
1185652009807	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
1185652009808	active site
1185652009809	hexamer interface [polypeptide binding]; other site
1185652009810	Chain length determinant protein; Region: Wzz; cl15801
1185652009811	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1185652009812	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1185652009813	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1185652009814	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
1185652009815	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
1185652009816	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1185652009817	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1185652009818	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1185652009819	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
1185652009820	SLBB domain; Region: SLBB; pfam10531
1185652009821	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
1185652009822	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
1185652009823	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1185652009824	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1185652009825	inhibitor-cofactor binding pocket; inhibition site
1185652009826	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652009827	catalytic residue [active]
1185652009828	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1185652009829	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
1185652009830	putative ADP-binding pocket [chemical binding]; other site
1185652009831	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1185652009832	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1185652009833	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1185652009834	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1185652009835	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928
1185652009836	NodB motif; other site
1185652009837	putative active site [active]
1185652009838	putative catalytic site [active]
1185652009839	putative Zn binding site [ion binding]; other site
1185652009840	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1185652009841	Protein of unknown function (DUF3095); Region: DUF3095; pfam11294
1185652009842	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
1185652009843	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1185652009844	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1185652009845	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1185652009846	Predicted integral membrane protein [Function unknown]; Region: COG5616
1185652009847	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652009848	cyclase homology domain; Region: CHD; cd07302
1185652009849	nucleotidyl binding site; other site
1185652009850	metal binding site [ion binding]; metal-binding site
1185652009851	dimer interface [polypeptide binding]; other site
1185652009852	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
1185652009853	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1185652009854	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652009855	Walker A/P-loop; other site
1185652009856	ATP binding site [chemical binding]; other site
1185652009857	Q-loop/lid; other site
1185652009858	ABC transporter signature motif; other site
1185652009859	Walker B; other site
1185652009860	D-loop; other site
1185652009861	H-loop/switch region; other site
1185652009862	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1185652009863	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652009864	Walker A/P-loop; other site
1185652009865	ATP binding site [chemical binding]; other site
1185652009866	Q-loop/lid; other site
1185652009867	ABC transporter signature motif; other site
1185652009868	Walker B; other site
1185652009869	D-loop; other site
1185652009870	H-loop/switch region; other site
1185652009871	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652009872	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
1185652009873	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1185652009874	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1185652009875	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652009876	dimer interface [polypeptide binding]; other site
1185652009877	conserved gate region; other site
1185652009878	putative PBP binding loops; other site
1185652009879	ABC-ATPase subunit interface; other site
1185652009880	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1185652009881	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
1185652009882	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652009883	dimer interface [polypeptide binding]; other site
1185652009884	conserved gate region; other site
1185652009885	putative PBP binding loops; other site
1185652009886	ABC-ATPase subunit interface; other site
1185652009887	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
1185652009888	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
1185652009889	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
1185652009890	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
1185652009891	putative ADP-binding pocket [chemical binding]; other site
1185652009892	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
1185652009893	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1185652009894	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1185652009895	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1185652009896	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652009897	Q-loop/lid; other site
1185652009898	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1185652009899	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652009900	ABC transporter signature motif; other site
1185652009901	Walker B; other site
1185652009902	D-loop; other site
1185652009903	H-loop/switch region; other site
1185652009904	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1185652009905	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1185652009906	ligand binding site [chemical binding]; other site
1185652009907	flexible hinge region; other site
1185652009908	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
1185652009909	Predicted metal-binding protein [General function prediction only]; Region: COG3019
1185652009910	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
1185652009911	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
1185652009912	DNA binding residues [nucleotide binding]
1185652009913	dimer interface [polypeptide binding]; other site
1185652009914	copper binding site [ion binding]; other site
1185652009915	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1185652009916	metal-binding site [ion binding]
1185652009917	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1185652009918	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1185652009919	metal-binding site [ion binding]
1185652009920	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1185652009921	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652009922	motif II; other site
1185652009923	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
1185652009924	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
1185652009925	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
1185652009926	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1185652009927	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1185652009928	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1185652009929	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
1185652009930	SLBB domain; Region: SLBB; pfam10531
1185652009931	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
1185652009932	Chain length determinant protein; Region: Wzz; pfam02706
1185652009933	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
1185652009934	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1185652009935	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1185652009936	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1185652009937	trimer interface [polypeptide binding]; other site
1185652009938	active site
1185652009939	substrate binding site [chemical binding]; other site
1185652009940	CoA binding site [chemical binding]; other site
1185652009941	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
1185652009942	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1185652009943	active site
1185652009944	metal binding site [ion binding]; metal-binding site
1185652009945	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
1185652009946	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
1185652009947	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1185652009948	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
1185652009949	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1185652009950	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1185652009951	agmatinase; Region: agmatinase; TIGR01230
1185652009952	oligomer interface [polypeptide binding]; other site
1185652009953	putative active site [active]
1185652009954	Mn binding site [ion binding]; other site
1185652009955	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1185652009956	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1185652009957	23S rRNA interface [nucleotide binding]; other site
1185652009958	L3 interface [polypeptide binding]; other site
1185652009959	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1185652009960	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
1185652009961	CoenzymeA binding site [chemical binding]; other site
1185652009962	subunit interaction site [polypeptide binding]; other site
1185652009963	PHB binding site; other site
1185652009964	enoyl-CoA hydratase; Validated; Region: PRK08139
1185652009965	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1185652009966	substrate binding site [chemical binding]; other site
1185652009967	oxyanion hole (OAH) forming residues; other site
1185652009968	trimer interface [polypeptide binding]; other site
1185652009969	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1185652009970	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
1185652009971	EamA-like transporter family; Region: EamA; pfam00892
1185652009972	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
1185652009973	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
1185652009974	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1185652009975	homodimer interface [polypeptide binding]; other site
1185652009976	substrate-cofactor binding pocket; other site
1185652009977	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652009978	catalytic residue [active]
1185652009979	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
1185652009980	Right handed beta helix region; Region: Beta_helix; pfam13229
1185652009981	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1185652009982	Cytochrome P450; Region: p450; cl12078
1185652009983	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
1185652009984	putative catalytic site [active]
1185652009985	putative metal binding site [ion binding]; other site
1185652009986	putative phosphate binding site [ion binding]; other site
1185652009987	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1185652009988	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
1185652009989	putative active site [active]
1185652009990	catalytic site [active]
1185652009991	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
1185652009992	putative active site [active]
1185652009993	catalytic site [active]
1185652009994	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1185652009995	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1185652009996	oligomer interface [polypeptide binding]; other site
1185652009997	active site residues [active]
1185652009998	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1185652009999	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1185652010000	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652010001	Walker A motif; other site
1185652010002	ATP binding site [chemical binding]; other site
1185652010003	Walker B motif; other site
1185652010004	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1185652010005	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1185652010006	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1185652010007	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1185652010008	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652010009	Walker A motif; other site
1185652010010	ATP binding site [chemical binding]; other site
1185652010011	Walker B motif; other site
1185652010012	arginine finger; other site
1185652010013	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1185652010014	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1185652010015	IHF dimer interface [polypeptide binding]; other site
1185652010016	IHF - DNA interface [nucleotide binding]; other site
1185652010017	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
1185652010018	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1185652010019	MarR family; Region: MarR; pfam01047
1185652010020	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1185652010021	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1185652010022	dimerization interface [polypeptide binding]; other site
1185652010023	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1185652010024	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1185652010025	dimer interface [polypeptide binding]; other site
1185652010026	putative CheW interface [polypeptide binding]; other site
1185652010027	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1185652010028	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1185652010029	active site
1185652010030	metal binding site [ion binding]; metal-binding site
1185652010031	DNA binding site [nucleotide binding]
1185652010032	P-loop containing region of AAA domain; Region: AAA_29; cl17516
1185652010033	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1185652010034	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
1185652010035	NADH dehydrogenase subunit D; Validated; Region: PRK06075
1185652010036	NADH dehydrogenase subunit E; Validated; Region: PRK07539
1185652010037	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1185652010038	putative dimer interface [polypeptide binding]; other site
1185652010039	[2Fe-2S] cluster binding site [ion binding]; other site
1185652010040	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
1185652010041	SLBB domain; Region: SLBB; pfam10531
1185652010042	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
1185652010043	Uncharacterized conserved protein [Function unknown]; Region: COG3743
1185652010044	NADH dehydrogenase subunit G; Validated; Region: PRK09130
1185652010045	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1185652010046	catalytic loop [active]
1185652010047	iron binding site [ion binding]; other site
1185652010048	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1185652010049	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1185652010050	molybdopterin cofactor binding site; other site
1185652010051	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
1185652010052	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1185652010053	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1185652010054	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
1185652010055	4Fe-4S binding domain; Region: Fer4; pfam00037
1185652010056	4Fe-4S binding domain; Region: Fer4; pfam00037
1185652010057	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
1185652010058	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1185652010059	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
1185652010060	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1185652010061	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1185652010062	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1185652010063	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1185652010064	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1185652010065	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1185652010066	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1185652010067	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1185652010068	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1185652010069	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1185652010070	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1185652010071	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1185652010072	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1185652010073	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1185652010074	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652010075	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
1185652010076	dimer interface [polypeptide binding]; other site
1185652010077	substrate binding site [chemical binding]; other site
1185652010078	metal binding site [ion binding]; metal-binding site
1185652010079	Protein of unknown function (DUF1467); Region: DUF1467; cl11569
1185652010080	prolyl-tRNA synthetase; Provisional; Region: PRK12325
1185652010081	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1185652010082	dimer interface [polypeptide binding]; other site
1185652010083	motif 1; other site
1185652010084	active site
1185652010085	motif 2; other site
1185652010086	motif 3; other site
1185652010087	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1185652010088	anticodon binding site; other site
1185652010089	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
1185652010090	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1185652010091	FtsX-like permease family; Region: FtsX; pfam02687
1185652010092	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1185652010093	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1185652010094	Walker A/P-loop; other site
1185652010095	ATP binding site [chemical binding]; other site
1185652010096	Q-loop/lid; other site
1185652010097	ABC transporter signature motif; other site
1185652010098	Walker B; other site
1185652010099	D-loop; other site
1185652010100	H-loop/switch region; other site
1185652010101	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
1185652010102	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1185652010103	putative active site [active]
1185652010104	putative PHP Thumb interface [polypeptide binding]; other site
1185652010105	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1185652010106	generic binding surface II; other site
1185652010107	generic binding surface I; other site
1185652010108	hypothetical protein; Provisional; Region: PRK06132
1185652010109	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1185652010110	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1185652010111	DNA polymerase IV; Provisional; Region: PRK02794
1185652010112	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1185652010113	active site
1185652010114	DNA binding site [nucleotide binding]
1185652010115	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
1185652010116	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1185652010117	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652010118	active site
1185652010119	phosphorylation site [posttranslational modification]
1185652010120	intermolecular recognition site; other site
1185652010121	dimerization interface [polypeptide binding]; other site
1185652010122	response regulator PleD; Reviewed; Region: pleD; PRK09581
1185652010123	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652010124	active site
1185652010125	phosphorylation site [posttranslational modification]
1185652010126	intermolecular recognition site; other site
1185652010127	dimerization interface [polypeptide binding]; other site
1185652010128	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652010129	active site
1185652010130	phosphorylation site [posttranslational modification]
1185652010131	intermolecular recognition site; other site
1185652010132	dimerization interface [polypeptide binding]; other site
1185652010133	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652010134	metal binding site [ion binding]; metal-binding site
1185652010135	active site
1185652010136	I-site; other site
1185652010137	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1185652010138	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652010139	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1185652010140	putative substrate translocation pore; other site
1185652010141	hypothetical protein; Provisional; Region: PRK05978
1185652010142	ribonuclease R; Region: RNase_R; TIGR02063
1185652010143	RNB domain; Region: RNB; pfam00773
1185652010144	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1185652010145	RNA binding site [nucleotide binding]; other site
1185652010146	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1185652010147	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1185652010148	active site
1185652010149	interdomain interaction site; other site
1185652010150	putative metal-binding site [ion binding]; other site
1185652010151	nucleotide binding site [chemical binding]; other site
1185652010152	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1185652010153	domain I; other site
1185652010154	DNA binding groove [nucleotide binding]
1185652010155	phosphate binding site [ion binding]; other site
1185652010156	domain II; other site
1185652010157	domain III; other site
1185652010158	nucleotide binding site [chemical binding]; other site
1185652010159	catalytic site [active]
1185652010160	domain IV; other site
1185652010161	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1185652010162	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1185652010163	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1185652010164	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1185652010165	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
1185652010166	DNA protecting protein DprA; Region: dprA; TIGR00732
1185652010167	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1185652010168	dihydroorotase; Validated; Region: PRK09059
1185652010169	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1185652010170	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1185652010171	active site
1185652010172	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1185652010173	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1185652010174	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1185652010175	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1185652010176	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1185652010177	active site
1185652010178	Predicted permeases [General function prediction only]; Region: COG0679
1185652010179	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1185652010180	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1185652010181	metal-dependent hydrolase; Provisional; Region: PRK00685
1185652010182	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1185652010183	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1185652010184	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1185652010185	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1185652010186	hypothetical protein; Provisional; Region: PRK13687
1185652010187	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1185652010188	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1185652010189	GatB domain; Region: GatB_Yqey; smart00845
1185652010190	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1185652010191	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652010192	Coenzyme A binding pocket [chemical binding]; other site
1185652010193	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1185652010194	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1185652010195	NADH dehydrogenase; Validated; Region: PRK08183
1185652010196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765
1185652010197	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
1185652010198	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1185652010199	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1185652010200	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1185652010201	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1185652010202	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1185652010203	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1185652010204	carboxyltransferase (CT) interaction site; other site
1185652010205	biotinylation site [posttranslational modification]; other site
1185652010206	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1185652010207	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1185652010208	trimer interface [polypeptide binding]; other site
1185652010209	active site
1185652010210	dimer interface [polypeptide binding]; other site
1185652010211	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
1185652010212	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1185652010213	catalytic residues [active]
1185652010214	aspartate aminotransferase; Provisional; Region: PRK05764
1185652010215	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652010216	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652010217	homodimer interface [polypeptide binding]; other site
1185652010218	catalytic residue [active]
1185652010219	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1185652010220	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1185652010221	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
1185652010222	AMIN domain; Region: AMIN; pfam11741
1185652010223	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1185652010224	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1185652010225	active site
1185652010226	metal binding site [ion binding]; metal-binding site
1185652010227	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
1185652010228	Transglycosylase; Region: Transgly; pfam00912
1185652010229	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1185652010230	peptide chain release factor 2; Provisional; Region: PRK07342
1185652010231	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1185652010232	RF-1 domain; Region: RF-1; pfam00472
1185652010233	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
1185652010234	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1185652010235	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
1185652010236	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1185652010237	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1185652010238	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1185652010239	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1185652010240	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652010241	extended (e) SDRs; Region: SDR_e; cd08946
1185652010242	NAD(P) binding site [chemical binding]; other site
1185652010243	active site
1185652010244	substrate binding site [chemical binding]; other site
1185652010245	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1185652010246	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1185652010247	putative homodimer interface [polypeptide binding]; other site
1185652010248	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1185652010249	heterodimer interface [polypeptide binding]; other site
1185652010250	homodimer interface [polypeptide binding]; other site
1185652010251	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1185652010252	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1185652010253	23S rRNA interface [nucleotide binding]; other site
1185652010254	L7/L12 interface [polypeptide binding]; other site
1185652010255	putative thiostrepton binding site; other site
1185652010256	L25 interface [polypeptide binding]; other site
1185652010257	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1185652010258	mRNA/rRNA interface [nucleotide binding]; other site
1185652010259	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1185652010260	23S rRNA interface [nucleotide binding]; other site
1185652010261	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1185652010262	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1185652010263	core dimer interface [polypeptide binding]; other site
1185652010264	peripheral dimer interface [polypeptide binding]; other site
1185652010265	L10 interface [polypeptide binding]; other site
1185652010266	L11 interface [polypeptide binding]; other site
1185652010267	putative EF-Tu interaction site [polypeptide binding]; other site
1185652010268	putative EF-G interaction site [polypeptide binding]; other site
1185652010269	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1185652010270	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1185652010271	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1185652010272	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1185652010273	RPB11 interaction site [polypeptide binding]; other site
1185652010274	RPB12 interaction site [polypeptide binding]; other site
1185652010275	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1185652010276	RPB1 interaction site [polypeptide binding]; other site
1185652010277	RPB11 interaction site [polypeptide binding]; other site
1185652010278	RPB10 interaction site [polypeptide binding]; other site
1185652010279	RPB3 interaction site [polypeptide binding]; other site
1185652010280	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1185652010281	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
1185652010282	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1185652010283	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1185652010284	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1185652010285	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1185652010286	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1185652010287	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1185652010288	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1185652010289	DNA binding site [nucleotide binding]
1185652010290	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1185652010291	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1185652010292	S17 interaction site [polypeptide binding]; other site
1185652010293	S8 interaction site; other site
1185652010294	16S rRNA interaction site [nucleotide binding]; other site
1185652010295	streptomycin interaction site [chemical binding]; other site
1185652010296	23S rRNA interaction site [nucleotide binding]; other site
1185652010297	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1185652010298	30S ribosomal protein S7; Validated; Region: PRK05302
1185652010299	elongation factor G; Reviewed; Region: PRK00007
1185652010300	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1185652010301	G1 box; other site
1185652010302	putative GEF interaction site [polypeptide binding]; other site
1185652010303	GTP/Mg2+ binding site [chemical binding]; other site
1185652010304	Switch I region; other site
1185652010305	G2 box; other site
1185652010306	G3 box; other site
1185652010307	Switch II region; other site
1185652010308	G4 box; other site
1185652010309	G5 box; other site
1185652010310	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1185652010311	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1185652010312	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1185652010313	elongation factor Tu; Reviewed; Region: PRK00049
1185652010314	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1185652010315	G1 box; other site
1185652010316	GEF interaction site [polypeptide binding]; other site
1185652010317	GTP/Mg2+ binding site [chemical binding]; other site
1185652010318	Switch I region; other site
1185652010319	G2 box; other site
1185652010320	G3 box; other site
1185652010321	Switch II region; other site
1185652010322	G4 box; other site
1185652010323	G5 box; other site
1185652010324	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1185652010325	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1185652010326	Antibiotic Binding Site [chemical binding]; other site
1185652010327	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1185652010328	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1185652010329	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1185652010330	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1185652010331	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1185652010332	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1185652010333	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1185652010334	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1185652010335	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1185652010336	putative translocon binding site; other site
1185652010337	protein-rRNA interface [nucleotide binding]; other site
1185652010338	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1185652010339	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1185652010340	G-X-X-G motif; other site
1185652010341	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1185652010342	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1185652010343	23S rRNA interface [nucleotide binding]; other site
1185652010344	5S rRNA interface [nucleotide binding]; other site
1185652010345	putative antibiotic binding site [chemical binding]; other site
1185652010346	L25 interface [polypeptide binding]; other site
1185652010347	L27 interface [polypeptide binding]; other site
1185652010348	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1185652010349	23S rRNA interface [nucleotide binding]; other site
1185652010350	putative translocon interaction site; other site
1185652010351	signal recognition particle (SRP54) interaction site; other site
1185652010352	L23 interface [polypeptide binding]; other site
1185652010353	trigger factor interaction site; other site
1185652010354	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1185652010355	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1185652010356	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1185652010357	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1185652010358	RNA binding site [nucleotide binding]; other site
1185652010359	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1185652010360	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1185652010361	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1185652010362	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1185652010363	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1185652010364	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1185652010365	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1185652010366	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1185652010367	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1185652010368	23S rRNA interface [nucleotide binding]; other site
1185652010369	L21e interface [polypeptide binding]; other site
1185652010370	5S rRNA interface [nucleotide binding]; other site
1185652010371	L27 interface [polypeptide binding]; other site
1185652010372	L5 interface [polypeptide binding]; other site
1185652010373	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1185652010374	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1185652010375	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1185652010376	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1185652010377	23S rRNA binding site [nucleotide binding]; other site
1185652010378	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1185652010379	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1185652010380	SecY translocase; Region: SecY; pfam00344
1185652010381	adenylate kinase; Reviewed; Region: adk; PRK00279
1185652010382	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1185652010383	AMP-binding site [chemical binding]; other site
1185652010384	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1185652010385	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
1185652010386	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1185652010387	30S ribosomal protein S11; Validated; Region: PRK05309
1185652010388	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1185652010389	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1185652010390	alphaNTD homodimer interface [polypeptide binding]; other site
1185652010391	alphaNTD - beta interaction site [polypeptide binding]; other site
1185652010392	alphaNTD - beta' interaction site [polypeptide binding]; other site
1185652010393	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1185652010394	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1185652010395	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
1185652010396	TMAO/DMSO reductase; Reviewed; Region: PRK05363
1185652010397	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1185652010398	Moco binding site; other site
1185652010399	metal coordination site [ion binding]; other site
1185652010400	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1185652010401	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1185652010402	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1185652010403	protein binding site [polypeptide binding]; other site
1185652010404	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1185652010405	protein binding site [polypeptide binding]; other site
1185652010406	recombination factor protein RarA; Reviewed; Region: PRK13342
1185652010407	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652010408	Walker A motif; other site
1185652010409	ATP binding site [chemical binding]; other site
1185652010410	Walker B motif; other site
1185652010411	arginine finger; other site
1185652010412	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1185652010413	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1185652010414	Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387
1185652010415	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1185652010416	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652010417	motif II; other site
1185652010418	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1185652010419	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
1185652010420	RNA binding surface [nucleotide binding]; other site
1185652010421	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1185652010422	active site
1185652010423	Domain of unknown function (DUF1883); Region: DUF1883; pfam08980
1185652010424	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
1185652010425	S-formylglutathione hydrolase; Region: PLN02442
1185652010426	Predicted membrane protein [Function unknown]; Region: COG4291
1185652010427	hypothetical protein; Validated; Region: PRK00124
1185652010428	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652010429	non-specific DNA binding site [nucleotide binding]; other site
1185652010430	salt bridge; other site
1185652010431	sequence-specific DNA binding site [nucleotide binding]; other site
1185652010432	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1185652010433	lipoate-protein ligase B; Provisional; Region: PRK14341
1185652010434	Chalcone-flavanone isomerase; Region: Chalcone; cl03589
1185652010435	PrkA family serine protein kinase; Provisional; Region: PRK15455
1185652010436	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1185652010437	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
1185652010438	Uncharacterized conserved protein [Function unknown]; Region: COG2718
1185652010439	SpoVR family protein; Provisional; Region: PRK11767
1185652010440	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
1185652010441	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1185652010442	active site
1185652010443	catalytic residues [active]
1185652010444	metal binding site [ion binding]; metal-binding site
1185652010445	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1185652010446	MgtE intracellular N domain; Region: MgtE_N; smart00924
1185652010447	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1185652010448	Divalent cation transporter; Region: MgtE; cl00786
1185652010449	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1185652010450	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
1185652010451	DNA binding residues [nucleotide binding]
1185652010452	putative dimer interface [polypeptide binding]; other site
1185652010453	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1185652010454	Protein of unknown function (DUF1624); Region: DUF1624; pfam07786
1185652010455	Predicted membrane protein [Function unknown]; Region: COG3821
1185652010456	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1185652010457	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1185652010458	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1185652010459	Uncharacterized conserved protein [Function unknown]; Region: COG5458
1185652010460	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1185652010461	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1185652010462	Sporulation related domain; Region: SPOR; pfam05036
1185652010463	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
1185652010464	PilZ domain; Region: PilZ; pfam07238
1185652010465	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1185652010466	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
1185652010467	FOG: CBS domain [General function prediction only]; Region: COG0517
1185652010468	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1185652010469	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1185652010470	nucleophile elbow; other site
1185652010471	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1185652010472	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
1185652010473	GTP cyclohydrolase I; Provisional; Region: PLN03044
1185652010474	active site
1185652010475	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1185652010476	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1185652010477	trimerization site [polypeptide binding]; other site
1185652010478	active site
1185652010479	hypothetical protein; Validated; Region: PRK00041
1185652010480	Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314
1185652010481	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
1185652010482	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1185652010483	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1185652010484	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1185652010485	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1185652010486	active site
1185652010487	dimer interface [polypeptide binding]; other site
1185652010488	motif 1; other site
1185652010489	motif 2; other site
1185652010490	motif 3; other site
1185652010491	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1185652010492	anticodon binding site; other site
1185652010493	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1185652010494	putative FMN binding site [chemical binding]; other site
1185652010495	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1185652010496	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1185652010497	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
1185652010498	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
1185652010499	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1185652010500	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652010501	Coenzyme A binding pocket [chemical binding]; other site
1185652010502	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1185652010503	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652010504	Mg2+ binding site [ion binding]; other site
1185652010505	G-X-G motif; other site
1185652010506	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1185652010507	anchoring element; other site
1185652010508	dimer interface [polypeptide binding]; other site
1185652010509	ATP binding site [chemical binding]; other site
1185652010510	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1185652010511	active site
1185652010512	metal binding site [ion binding]; metal-binding site
1185652010513	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1185652010514	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1185652010515	FAD binding domain; Region: FAD_binding_4; pfam01565
1185652010516	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1185652010517	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1185652010518	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1185652010519	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1185652010520	triosephosphate isomerase; Provisional; Region: PRK14565
1185652010521	substrate binding site [chemical binding]; other site
1185652010522	dimer interface [polypeptide binding]; other site
1185652010523	catalytic triad [active]
1185652010524	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
1185652010525	CTP synthetase; Validated; Region: pyrG; PRK05380
1185652010526	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1185652010527	Catalytic site [active]
1185652010528	active site
1185652010529	UTP binding site [chemical binding]; other site
1185652010530	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1185652010531	active site
1185652010532	putative oxyanion hole; other site
1185652010533	catalytic triad [active]
1185652010534	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1185652010535	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
1185652010536	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1185652010537	enolase; Provisional; Region: eno; PRK00077
1185652010538	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1185652010539	dimer interface [polypeptide binding]; other site
1185652010540	metal binding site [ion binding]; metal-binding site
1185652010541	substrate binding pocket [chemical binding]; other site
1185652010542	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1185652010543	Septum formation initiator; Region: DivIC; pfam04977
1185652010544	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
1185652010545	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1185652010546	tetramer interface [polypeptide binding]; other site
1185652010547	TPP-binding site [chemical binding]; other site
1185652010548	heterodimer interface [polypeptide binding]; other site
1185652010549	phosphorylation loop region [posttranslational modification]
1185652010550	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
1185652010551	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1185652010552	E3 interaction surface; other site
1185652010553	lipoyl attachment site [posttranslational modification]; other site
1185652010554	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1185652010555	alpha subunit interface [polypeptide binding]; other site
1185652010556	TPP binding site [chemical binding]; other site
1185652010557	heterodimer interface [polypeptide binding]; other site
1185652010558	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1185652010559	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1185652010560	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
1185652010561	E3 interaction surface; other site
1185652010562	lipoyl attachment site [posttranslational modification]; other site
1185652010563	e3 binding domain; Region: E3_binding; pfam02817
1185652010564	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1185652010565	SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839
1185652010566	active site
1185652010567	catalytic triad [active]
1185652010568	oxyanion hole [active]
1185652010569	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652010570	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1185652010571	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1185652010572	Coenzyme A binding pocket [chemical binding]; other site
1185652010573	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1185652010574	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1185652010575	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652010576	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1185652010577	Predicted membrane protein [Function unknown]; Region: COG2261
1185652010578	lipoyl synthase; Provisional; Region: PRK05481
1185652010579	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1185652010580	FeS/SAM binding site; other site
1185652010581	formate dehydrogenase; Provisional; Region: PRK07574
1185652010582	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
1185652010583	dimerization interface [polypeptide binding]; other site
1185652010584	ligand binding site [chemical binding]; other site
1185652010585	NAD binding site [chemical binding]; other site
1185652010586	catalytic site [active]
1185652010587	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
1185652010588	putative coenzyme Q binding site [chemical binding]; other site
1185652010589	Competence-damaged protein; Region: CinA; pfam02464
1185652010590	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
1185652010591	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1185652010592	substrate binding site; other site
1185652010593	dimer interface; other site
1185652010594	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1185652010595	homotrimer interaction site [polypeptide binding]; other site
1185652010596	zinc binding site [ion binding]; other site
1185652010597	CDP-binding sites; other site
1185652010598	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1185652010599	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
1185652010600	FMN binding site [chemical binding]; other site
1185652010601	active site
1185652010602	catalytic residues [active]
1185652010603	substrate binding site [chemical binding]; other site
1185652010604	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1185652010605	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1185652010606	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652010607	dimer interface [polypeptide binding]; other site
1185652010608	phosphorylation site [posttranslational modification]
1185652010609	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652010610	ATP binding site [chemical binding]; other site
1185652010611	Mg2+ binding site [ion binding]; other site
1185652010612	G-X-G motif; other site
1185652010613	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
1185652010614	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652010615	active site
1185652010616	phosphorylation site [posttranslational modification]
1185652010617	intermolecular recognition site; other site
1185652010618	dimerization interface [polypeptide binding]; other site
1185652010619	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652010620	Walker A motif; other site
1185652010621	ATP binding site [chemical binding]; other site
1185652010622	Walker B motif; other site
1185652010623	arginine finger; other site
1185652010624	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
1185652010625	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
1185652010626	HAMP domain; Region: HAMP; pfam00672
1185652010627	dimerization interface [polypeptide binding]; other site
1185652010628	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652010629	dimer interface [polypeptide binding]; other site
1185652010630	phosphorylation site [posttranslational modification]
1185652010631	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652010632	ATP binding site [chemical binding]; other site
1185652010633	Mg2+ binding site [ion binding]; other site
1185652010634	G-X-G motif; other site
1185652010635	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1185652010636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652010637	active site
1185652010638	phosphorylation site [posttranslational modification]
1185652010639	intermolecular recognition site; other site
1185652010640	dimerization interface [polypeptide binding]; other site
1185652010641	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652010642	Walker A motif; other site
1185652010643	ATP binding site [chemical binding]; other site
1185652010644	Walker B motif; other site
1185652010645	arginine finger; other site
1185652010646	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1185652010647	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1185652010648	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1185652010649	homodimer interface [polypeptide binding]; other site
1185652010650	substrate-cofactor binding pocket; other site
1185652010651	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652010652	catalytic residue [active]
1185652010653	bacterial Hfq-like; Region: Hfq; cd01716
1185652010654	hexamer interface [polypeptide binding]; other site
1185652010655	Sm1 motif; other site
1185652010656	RNA binding site [nucleotide binding]; other site
1185652010657	Sm2 motif; other site
1185652010658	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1185652010659	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1185652010660	HflX GTPase family; Region: HflX; cd01878
1185652010661	G1 box; other site
1185652010662	GTP/Mg2+ binding site [chemical binding]; other site
1185652010663	Switch I region; other site
1185652010664	G2 box; other site
1185652010665	G3 box; other site
1185652010666	Switch II region; other site
1185652010667	G4 box; other site
1185652010668	G5 box; other site
1185652010669	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
1185652010670	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1185652010671	homodimer interface [polypeptide binding]; other site
1185652010672	metal binding site [ion binding]; metal-binding site
1185652010673	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1185652010674	homodimer interface [polypeptide binding]; other site
1185652010675	active site
1185652010676	putative chemical substrate binding site [chemical binding]; other site
1185652010677	metal binding site [ion binding]; metal-binding site
1185652010678	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1185652010679	nucleoside/Zn binding site; other site
1185652010680	dimer interface [polypeptide binding]; other site
1185652010681	catalytic motif [active]
1185652010682	siroheme synthase; Provisional; Region: cysG; PRK10637
1185652010683	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1185652010684	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
1185652010685	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1185652010686	active site
1185652010687	SAM binding site [chemical binding]; other site
1185652010688	homodimer interface [polypeptide binding]; other site
1185652010689	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
1185652010690	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
1185652010691	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1185652010692	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1185652010693	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749
1185652010694	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1185652010695	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
1185652010696	FAD binding pocket [chemical binding]; other site
1185652010697	FAD binding motif [chemical binding]; other site
1185652010698	phosphate binding motif [ion binding]; other site
1185652010699	beta-alpha-beta structure motif; other site
1185652010700	NAD binding pocket [chemical binding]; other site
1185652010701	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1185652010702	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1185652010703	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1185652010704	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1185652010705	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652010706	DNA-binding site [nucleotide binding]; DNA binding site
1185652010707	FCD domain; Region: FCD; pfam07729
1185652010708	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1185652010709	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1185652010710	inhibitor site; inhibition site
1185652010711	active site
1185652010712	dimer interface [polypeptide binding]; other site
1185652010713	catalytic residue [active]
1185652010714	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1185652010715	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1185652010716	Walker A/P-loop; other site
1185652010717	ATP binding site [chemical binding]; other site
1185652010718	Q-loop/lid; other site
1185652010719	ABC transporter signature motif; other site
1185652010720	Walker B; other site
1185652010721	D-loop; other site
1185652010722	H-loop/switch region; other site
1185652010723	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1185652010724	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652010725	dimer interface [polypeptide binding]; other site
1185652010726	conserved gate region; other site
1185652010727	putative PBP binding loops; other site
1185652010728	ABC-ATPase subunit interface; other site
1185652010729	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
1185652010730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1185652010731	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652010732	putative PBP binding loops; other site
1185652010733	dimer interface [polypeptide binding]; other site
1185652010734	ABC-ATPase subunit interface; other site
1185652010735	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1185652010736	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652010737	substrate binding pocket [chemical binding]; other site
1185652010738	membrane-bound complex binding site; other site
1185652010739	hinge residues; other site
1185652010740	cystathionine beta-lyase; Provisional; Region: PRK05967
1185652010741	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1185652010742	homodimer interface [polypeptide binding]; other site
1185652010743	substrate-cofactor binding pocket; other site
1185652010744	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652010745	catalytic residue [active]
1185652010746	salicylate hydroxylase; Provisional; Region: PRK08163
1185652010747	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1185652010748	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
1185652010749	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1185652010750	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1185652010751	serine acetyltransferase; Provisional; Region: cysE; PRK11132
1185652010752	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
1185652010753	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1185652010754	trimer interface [polypeptide binding]; other site
1185652010755	active site
1185652010756	substrate binding site [chemical binding]; other site
1185652010757	CoA binding site [chemical binding]; other site
1185652010758	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
1185652010759	Phasin protein; Region: Phasin_2; pfam09361
1185652010760	Uncharacterized conserved protein [Function unknown]; Region: COG2127
1185652010761	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
1185652010762	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652010763	Walker A motif; other site
1185652010764	ATP binding site [chemical binding]; other site
1185652010765	Walker B motif; other site
1185652010766	arginine finger; other site
1185652010767	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652010768	Walker A motif; other site
1185652010769	ATP binding site [chemical binding]; other site
1185652010770	Walker B motif; other site
1185652010771	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1185652010772	AzlC protein; Region: AzlC; pfam03591
1185652010773	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1185652010774	HIT family signature motif; other site
1185652010775	catalytic residue [active]
1185652010776	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
1185652010777	Protein of unknown function, DUF482; Region: DUF482; pfam04339
1185652010778	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585
1185652010779	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1185652010780	putative active site [active]
1185652010781	catalytic site [active]
1185652010782	putative metal binding site [ion binding]; other site
1185652010783	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1185652010784	homotrimer interaction site [polypeptide binding]; other site
1185652010785	putative active site [active]
1185652010786	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
1185652010787	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1185652010788	rRNA interaction site [nucleotide binding]; other site
1185652010789	S8 interaction site; other site
1185652010790	putative laminin-1 binding site; other site
1185652010791	elongation factor Ts; Provisional; Region: tsf; PRK09377
1185652010792	UBA/TS-N domain; Region: UBA; pfam00627
1185652010793	Elongation factor TS; Region: EF_TS; pfam00889
1185652010794	Elongation factor TS; Region: EF_TS; pfam00889
1185652010795	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1185652010796	putative nucleotide binding site [chemical binding]; other site
1185652010797	uridine monophosphate binding site [chemical binding]; other site
1185652010798	homohexameric interface [polypeptide binding]; other site
1185652010799	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1185652010800	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1185652010801	hinge region; other site
1185652010802	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834
1185652010803	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1185652010804	catalytic residue [active]
1185652010805	putative FPP diphosphate  binding site; other site
1185652010806	putative FPP binding hydrophobic cleft; other site
1185652010807	dimer interface [polypeptide binding]; other site
1185652010808	putative IPP diphosphate binding site; other site
1185652010809	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1185652010810	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1185652010811	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
1185652010812	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1185652010813	active site
1185652010814	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1185652010815	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1185652010816	putative substrate binding region [chemical binding]; other site
1185652010817	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
1185652010818	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1185652010819	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1185652010820	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1185652010821	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1185652010822	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1185652010823	Surface antigen; Region: Bac_surface_Ag; pfam01103
1185652010824	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1185652010825	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1185652010826	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1185652010827	trimer interface [polypeptide binding]; other site
1185652010828	active site
1185652010829	UDP-GlcNAc binding site [chemical binding]; other site
1185652010830	lipid binding site [chemical binding]; lipid-binding site
1185652010831	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1185652010832	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1185652010833	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1185652010834	active site
1185652010835	Protein of unknown function (DUF1009); Region: DUF1009; cl09182
1185652010836	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
1185652010837	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1185652010838	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1185652010839	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1185652010840	dimer interface [polypeptide binding]; other site
1185652010841	active site
1185652010842	citrylCoA binding site [chemical binding]; other site
1185652010843	NADH binding [chemical binding]; other site
1185652010844	cationic pore residues; other site
1185652010845	oxalacetate/citrate binding site [chemical binding]; other site
1185652010846	coenzyme A binding site [chemical binding]; other site
1185652010847	catalytic triad [active]
1185652010848	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1185652010849	Competence protein; Region: Competence; pfam03772
1185652010850	tonB-system energizer ExbB; Region: exbB; TIGR02797
1185652010851	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1185652010852	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
1185652010853	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
1185652010854	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652010855	S-adenosylmethionine binding site [chemical binding]; other site
1185652010856	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1185652010857	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827
1185652010858	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1185652010859	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1185652010860	HIGH motif; other site
1185652010861	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1185652010862	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1185652010863	active site
1185652010864	KMSKS motif; other site
1185652010865	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1185652010866	tRNA binding surface [nucleotide binding]; other site
1185652010867	anticodon binding site; other site
1185652010868	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1185652010869	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
1185652010870	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1185652010871	Sel1-like repeats; Region: SEL1; smart00671
1185652010872	Sel1-like repeats; Region: SEL1; smart00671
1185652010873	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1185652010874	putative catalytic site [active]
1185652010875	putative phosphate binding site [ion binding]; other site
1185652010876	active site
1185652010877	metal binding site A [ion binding]; metal-binding site
1185652010878	DNA binding site [nucleotide binding]
1185652010879	putative AP binding site [nucleotide binding]; other site
1185652010880	putative metal binding site B [ion binding]; other site
1185652010881	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1185652010882	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
1185652010883	putative active site [active]
1185652010884	catalytic site [active]
1185652010885	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
1185652010886	putative active site [active]
1185652010887	catalytic site [active]
1185652010888	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1185652010889	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
1185652010890	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1185652010891	Zn2+ binding site [ion binding]; other site
1185652010892	Mg2+ binding site [ion binding]; other site
1185652010893	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1185652010894	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
1185652010895	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1185652010896	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1185652010897	active site
1185652010898	HIGH motif; other site
1185652010899	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1185652010900	KMSK motif region; other site
1185652010901	tRNA binding surface [nucleotide binding]; other site
1185652010902	DALR anticodon binding domain; Region: DALR_1; smart00836
1185652010903	anticodon binding site; other site
1185652010904	Sporulation related domain; Region: SPOR; pfam05036
1185652010905	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1185652010906	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1185652010907	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1185652010908	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
1185652010909	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1185652010910	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1185652010911	Walker A/P-loop; other site
1185652010912	ATP binding site [chemical binding]; other site
1185652010913	Q-loop/lid; other site
1185652010914	ABC transporter signature motif; other site
1185652010915	Walker B; other site
1185652010916	D-loop; other site
1185652010917	H-loop/switch region; other site
1185652010918	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
1185652010919	sec-independent translocase; Provisional; Region: PRK00708
1185652010920	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
1185652010921	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1185652010922	seryl-tRNA synthetase; Provisional; Region: PRK05431
1185652010923	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1185652010924	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1185652010925	dimer interface [polypeptide binding]; other site
1185652010926	active site
1185652010927	motif 1; other site
1185652010928	motif 2; other site
1185652010929	motif 3; other site
1185652010930	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1185652010931	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
1185652010932	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652010933	S-adenosylmethionine binding site [chemical binding]; other site
1185652010934	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1185652010935	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1185652010936	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1185652010937	Peptidase family M23; Region: Peptidase_M23; pfam01551
1185652010938	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
1185652010939	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652010940	Walker A motif; other site
1185652010941	ATP binding site [chemical binding]; other site
1185652010942	Walker B motif; other site
1185652010943	Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862
1185652010944	bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726
1185652010945	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1185652010946	Protein export membrane protein; Region: SecD_SecF; pfam02355
1185652010947	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
1185652010948	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
1185652010949	aspartate-rich region 1; other site
1185652010950	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1185652010951	Glucose inhibited division protein A; Region: GIDA; pfam01134
1185652010952	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
1185652010953	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
1185652010954	trigger factor; Provisional; Region: tig; PRK01490
1185652010955	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1185652010956	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1185652010957	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1185652010958	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
1185652010959	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1185652010960	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652010961	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1185652010962	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1185652010963	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
1185652010964	oligomer interface [polypeptide binding]; other site
1185652010965	metal binding site [ion binding]; metal-binding site
1185652010966	metal binding site [ion binding]; metal-binding site
1185652010967	putative Cl binding site [ion binding]; other site
1185652010968	basic sphincter; other site
1185652010969	hydrophobic gate; other site
1185652010970	periplasmic entrance; other site
1185652010971	hypothetical protein; Reviewed; Region: PRK00024
1185652010972	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1185652010973	MPN+ (JAMM) motif; other site
1185652010974	Zinc-binding site [ion binding]; other site
1185652010975	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1185652010976	active site
1185652010977	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
1185652010978	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
1185652010979	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
1185652010980	Short C-terminal domain; Region: SHOCT; pfam09851
1185652010981	aminotransferase; Validated; Region: PRK09148
1185652010982	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652010983	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652010984	homodimer interface [polypeptide binding]; other site
1185652010985	catalytic residue [active]
1185652010986	homoserine dehydrogenase; Provisional; Region: PRK06349
1185652010987	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1185652010988	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1185652010989	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1185652010990	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1185652010991	DHH family; Region: DHH; pfam01368
1185652010992	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
1185652010993	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1185652010994	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
1185652010995	AAA domain; Region: AAA_25; pfam13481
1185652010996	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1185652010997	Walker A motif; other site
1185652010998	ATP binding site [chemical binding]; other site
1185652010999	Walker B motif; other site
1185652011000	Helix-turn-helix domain; Region: HTH_17; cl17695
1185652011001	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1185652011002	non-specific DNA binding site [nucleotide binding]; other site
1185652011003	salt bridge; other site
1185652011004	sequence-specific DNA binding site [nucleotide binding]; other site
1185652011005	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1185652011006	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1185652011007	active site
1185652011008	catalytic residues [active]
1185652011009	DNA binding site [nucleotide binding]
1185652011010	Int/Topo IB signature motif; other site
1185652011011	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652011012	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1185652011013	dimer interface [polypeptide binding]; other site
1185652011014	active site
1185652011015	metal binding site [ion binding]; metal-binding site
1185652011016	glutathione binding site [chemical binding]; other site
1185652011017	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1185652011018	DNA-binding site [nucleotide binding]; DNA binding site
1185652011019	RNA-binding motif; other site
1185652011020	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1185652011021	DNA-binding site [nucleotide binding]; DNA binding site
1185652011022	RNA-binding motif; other site
1185652011023	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
1185652011024	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652011025	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652011026	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1185652011027	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
1185652011028	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1185652011029	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652011030	Walker A/P-loop; other site
1185652011031	ATP binding site [chemical binding]; other site
1185652011032	Q-loop/lid; other site
1185652011033	ABC transporter signature motif; other site
1185652011034	Walker B; other site
1185652011035	D-loop; other site
1185652011036	H-loop/switch region; other site
1185652011037	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652011038	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652011039	TM-ABC transporter signature motif; other site
1185652011040	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1185652011041	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
1185652011042	putative ligand binding site [chemical binding]; other site
1185652011043	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652011044	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652011045	DNA binding site [nucleotide binding]
1185652011046	domain linker motif; other site
1185652011047	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
1185652011048	putative ligand binding site [chemical binding]; other site
1185652011049	putative dimerization interface [polypeptide binding]; other site
1185652011050	Uncharacterized conserved protein [Function unknown]; Region: COG5569
1185652011051	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
1185652011052	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1185652011053	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1185652011054	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1185652011055	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1185652011056	Predicted membrane protein [Function unknown]; Region: COG1238
1185652011057	Cytochrome C' Region: Cytochrom_C_2; pfam01322
1185652011058	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1185652011059	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1185652011060	ligand binding site [chemical binding]; other site
1185652011061	flexible hinge region; other site
1185652011062	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
1185652011063	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
1185652011064	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1185652011065	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1185652011066	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1185652011067	Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695
1185652011068	Methylamine utilisation protein MauE; Region: MauE; pfam07291
1185652011069	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
1185652011070	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
1185652011071	DNA binding residues [nucleotide binding]
1185652011072	dimer interface [polypeptide binding]; other site
1185652011073	mercury binding site [ion binding]; other site
1185652011074	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1185652011075	active site
1185652011076	ATP binding site [chemical binding]; other site
1185652011077	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
1185652011078	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1185652011079	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1185652011080	conserved cys residue [active]
1185652011081	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652011082	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
1185652011083	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
1185652011084	Predicted permeases [General function prediction only]; Region: COG0679
1185652011085	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
1185652011086	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1185652011087	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1185652011088	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1185652011089	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
1185652011090	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1185652011091	NADP binding site [chemical binding]; other site
1185652011092	dimer interface [polypeptide binding]; other site
1185652011093	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1185652011094	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652011095	Walker A/P-loop; other site
1185652011096	ATP binding site [chemical binding]; other site
1185652011097	Q-loop/lid; other site
1185652011098	ABC transporter signature motif; other site
1185652011099	Walker B; other site
1185652011100	D-loop; other site
1185652011101	H-loop/switch region; other site
1185652011102	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652011103	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652011104	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1185652011105	TM-ABC transporter signature motif; other site
1185652011106	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652011107	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1185652011108	TM-ABC transporter signature motif; other site
1185652011109	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1185652011110	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
1185652011111	putative ligand binding site [chemical binding]; other site
1185652011112	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1185652011113	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652011114	DNA-binding site [nucleotide binding]; DNA binding site
1185652011115	FCD domain; Region: FCD; pfam07729
1185652011116	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1185652011117	Domain of unknown function DUF21; Region: DUF21; pfam01595
1185652011118	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1185652011119	Transporter associated domain; Region: CorC_HlyC; smart01091
1185652011120	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1185652011121	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1185652011122	dimer interface [polypeptide binding]; other site
1185652011123	putative functional site; other site
1185652011124	putative MPT binding site; other site
1185652011125	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1185652011126	trimer interface [polypeptide binding]; other site
1185652011127	dimer interface [polypeptide binding]; other site
1185652011128	putative active site [active]
1185652011129	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1185652011130	active site
1185652011131	ribulose/triose binding site [chemical binding]; other site
1185652011132	phosphate binding site [ion binding]; other site
1185652011133	substrate (anthranilate) binding pocket [chemical binding]; other site
1185652011134	product (indole) binding pocket [chemical binding]; other site
1185652011135	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1185652011136	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1185652011137	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1185652011138	SurA N-terminal domain; Region: SurA_N_3; cl07813
1185652011139	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
1185652011140	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
1185652011141	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1185652011142	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1185652011143	PhoU domain; Region: PhoU; pfam01895
1185652011144	PhoU domain; Region: PhoU; pfam01895
1185652011145	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
1185652011146	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1185652011147	Substrate binding site; other site
1185652011148	Mg++ binding site; other site
1185652011149	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1185652011150	active site
1185652011151	substrate binding site [chemical binding]; other site
1185652011152	CoA binding site [chemical binding]; other site
1185652011153	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1185652011154	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1185652011155	glutaminase active site [active]
1185652011156	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1185652011157	dimer interface [polypeptide binding]; other site
1185652011158	active site
1185652011159	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1185652011160	dimer interface [polypeptide binding]; other site
1185652011161	active site
1185652011162	putative acetyltransferase; Provisional; Region: PRK03624
1185652011163	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652011164	Coenzyme A binding pocket [chemical binding]; other site
1185652011165	Uncharacterized conserved protein [Function unknown]; Region: COG2928
1185652011166	RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200
1185652011167	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1185652011168	generic binding surface II; other site
1185652011169	ssDNA binding site; other site
1185652011170	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1185652011171	ATP binding site [chemical binding]; other site
1185652011172	putative Mg++ binding site [ion binding]; other site
1185652011173	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1185652011174	nucleotide binding region [chemical binding]; other site
1185652011175	ATP-binding site [chemical binding]; other site
1185652011176	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1185652011177	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1185652011178	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1185652011179	ATP binding site [chemical binding]; other site
1185652011180	putative Mg++ binding site [ion binding]; other site
1185652011181	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1185652011182	nucleotide binding region [chemical binding]; other site
1185652011183	ATP-binding site [chemical binding]; other site
1185652011184	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1185652011185	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1185652011186	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1185652011187	catalytic residues [active]
1185652011188	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1185652011189	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
1185652011190	Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342
1185652011191	Uncharacterized conserved protein [Function unknown]; Region: COG3785
1185652011192	glutamine synthetase; Provisional; Region: glnA; PRK09469
1185652011193	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1185652011194	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1185652011195	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1185652011196	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1185652011197	Uncharacterized conserved protein [Function unknown]; Region: COG0062
1185652011198	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1185652011199	putative substrate binding site [chemical binding]; other site
1185652011200	putative ATP binding site [chemical binding]; other site
1185652011201	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1185652011202	active site
1185652011203	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1185652011204	putative C-terminal domain interface [polypeptide binding]; other site
1185652011205	putative GSH binding site (G-site) [chemical binding]; other site
1185652011206	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1185652011207	putative dimer interface [polypeptide binding]; other site
1185652011208	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
1185652011209	dimer interface [polypeptide binding]; other site
1185652011210	N-terminal domain interface [polypeptide binding]; other site
1185652011211	putative substrate binding pocket (H-site) [chemical binding]; other site
1185652011212	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
1185652011213	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1185652011214	putative MPT binding site; other site
1185652011215	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1185652011216	MULE transposase domain; Region: MULE; pfam10551
1185652011217	threonine dehydratase; Validated; Region: PRK08639
1185652011218	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1185652011219	tetramer interface [polypeptide binding]; other site
1185652011220	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652011221	catalytic residue [active]
1185652011222	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1185652011223	Uncharacterized conserved protein [Function unknown]; Region: COG5453
1185652011224	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
1185652011225	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1185652011226	active site
1185652011227	metal binding site [ion binding]; metal-binding site
1185652011228	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1185652011229	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652011230	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652011231	metal binding site [ion binding]; metal-binding site
1185652011232	active site
1185652011233	I-site; other site
1185652011234	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652011235	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652011236	putative DNA binding site [nucleotide binding]; other site
1185652011237	putative Zn2+ binding site [ion binding]; other site
1185652011238	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652011239	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1185652011240	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1185652011241	hexamer interface [polypeptide binding]; other site
1185652011242	ligand binding site [chemical binding]; other site
1185652011243	putative active site [active]
1185652011244	NAD(P) binding site [chemical binding]; other site
1185652011245	Protein of unknown function (DUF1203); Region: DUF1203; pfam06718
1185652011246	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1185652011247	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1185652011248	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1185652011249	active site residue [active]
1185652011250	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1185652011251	active site residue [active]
1185652011252	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
1185652011253	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1185652011254	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1185652011255	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1185652011256	dimer interface [polypeptide binding]; other site
1185652011257	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652011258	catalytic residue [active]
1185652011259	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1185652011260	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652011261	NAD(P) binding site [chemical binding]; other site
1185652011262	active site
1185652011263	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1185652011264	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1185652011265	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
1185652011266	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652011267	S-adenosylmethionine binding site [chemical binding]; other site
1185652011268	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652011269	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1185652011270	Walker A/P-loop; other site
1185652011271	ATP binding site [chemical binding]; other site
1185652011272	Q-loop/lid; other site
1185652011273	ABC transporter signature motif; other site
1185652011274	Walker B; other site
1185652011275	D-loop; other site
1185652011276	H-loop/switch region; other site
1185652011277	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1185652011278	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652011279	S-adenosylmethionine binding site [chemical binding]; other site
1185652011280	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1185652011281	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652011282	Coenzyme A binding pocket [chemical binding]; other site
1185652011283	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1185652011284	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1185652011285	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914
1185652011286	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1185652011287	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1185652011288	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1185652011289	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652011290	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1185652011291	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1185652011292	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1185652011293	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1185652011294	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652011295	NAD(P) binding site [chemical binding]; other site
1185652011296	active site
1185652011297	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1185652011298	Helix-turn-helix domain; Region: HTH_18; pfam12833
1185652011299	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652011300	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652011301	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652011302	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652011303	dimerization interface [polypeptide binding]; other site
1185652011304	short chain dehydrogenase; Provisional; Region: PRK06500
1185652011305	classical (c) SDRs; Region: SDR_c; cd05233
1185652011306	NAD(P) binding site [chemical binding]; other site
1185652011307	active site
1185652011308	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1185652011309	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1185652011310	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1185652011311	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1185652011312	ligand binding site [chemical binding]; other site
1185652011313	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652011314	active site
1185652011315	classical (c) SDRs; Region: SDR_c; cd05233
1185652011316	NAD(P) binding site [chemical binding]; other site
1185652011317	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1185652011318	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652011319	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652011320	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
1185652011321	putative effector binding pocket; other site
1185652011322	putative dimerization interface [polypeptide binding]; other site
1185652011323	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1185652011324	Cupin domain; Region: Cupin_2; pfam07883
1185652011325	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1185652011326	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1185652011327	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
1185652011328	Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447
1185652011329	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652011330	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1185652011331	putative active site [active]
1185652011332	heme pocket [chemical binding]; other site
1185652011333	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652011334	putative active site [active]
1185652011335	heme pocket [chemical binding]; other site
1185652011336	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652011337	PAS fold; Region: PAS_3; pfam08447
1185652011338	putative active site [active]
1185652011339	heme pocket [chemical binding]; other site
1185652011340	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652011341	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652011342	ATP binding site [chemical binding]; other site
1185652011343	Mg2+ binding site [ion binding]; other site
1185652011344	G-X-G motif; other site
1185652011345	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
1185652011346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652011347	active site
1185652011348	phosphorylation site [posttranslational modification]
1185652011349	intermolecular recognition site; other site
1185652011350	dimerization interface [polypeptide binding]; other site
1185652011351	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652011352	DNA binding residues [nucleotide binding]
1185652011353	dimerization interface [polypeptide binding]; other site
1185652011354	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652011355	active site
1185652011356	phosphorylation site [posttranslational modification]
1185652011357	intermolecular recognition site; other site
1185652011358	dimerization interface [polypeptide binding]; other site
1185652011359	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
1185652011360	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652011361	active site
1185652011362	phosphorylation site [posttranslational modification]
1185652011363	intermolecular recognition site; other site
1185652011364	dimerization interface [polypeptide binding]; other site
1185652011365	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652011366	dimerization interface [polypeptide binding]; other site
1185652011367	DNA binding residues [nucleotide binding]
1185652011368	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1185652011369	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1185652011370	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652011371	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652011372	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1185652011373	putative substrate translocation pore; other site
1185652011374	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1185652011375	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1185652011376	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1185652011377	G-X-G motif; other site
1185652011378	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1185652011379	GXWXG protein; Region: GXWXG; pfam14231
1185652011380	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
1185652011381	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1185652011382	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1185652011383	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1185652011384	protein binding site [polypeptide binding]; other site
1185652011385	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652011386	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652011387	DNA binding residues [nucleotide binding]
1185652011388	dimerization interface [polypeptide binding]; other site
1185652011389	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1185652011390	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1185652011391	active site
1185652011392	Int/Topo IB signature motif; other site
1185652011393	DNA binding site [nucleotide binding]
1185652011394	LexA repressor; Validated; Region: PRK00215
1185652011395	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1185652011396	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1185652011397	Catalytic site [active]
1185652011398	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
1185652011399	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1185652011400	putative ligand binding site [chemical binding]; other site
1185652011401	putative NAD binding site [chemical binding]; other site
1185652011402	catalytic site [active]
1185652011403	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4289
1185652011404	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652011405	DNA binding site [nucleotide binding]
1185652011406	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652011407	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1185652011408	ligand binding site [chemical binding]; other site
1185652011409	dimerization interface [polypeptide binding]; other site
1185652011410	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652011411	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652011412	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1185652011413	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652011414	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652011415	dimerization interface [polypeptide binding]; other site
1185652011416	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1185652011417	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1185652011418	intersubunit interface [polypeptide binding]; other site
1185652011419	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1185652011420	cation binding site [ion binding]; other site
1185652011421	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1185652011422	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1185652011423	ABC-ATPase subunit  interface; other site
1185652011424	dimer interface [polypeptide binding]; other site
1185652011425	putative PBP binding regions; other site
1185652011426	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1185652011427	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1185652011428	ABC-ATPase subunit  interface; other site
1185652011429	dimer interface [polypeptide binding]; other site
1185652011430	putative PBP binding regions; other site
1185652011431	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1185652011432	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1185652011433	Walker A/P-loop; other site
1185652011434	ATP binding site [chemical binding]; other site
1185652011435	Q-loop/lid; other site
1185652011436	ABC transporter signature motif; other site
1185652011437	Walker B; other site
1185652011438	D-loop; other site
1185652011439	H-loop/switch region; other site
1185652011440	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
1185652011441	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1185652011442	Predicted integral membrane protein [Function unknown]; Region: COG5473
1185652011443	PilZ domain; Region: PilZ; pfam07238
1185652011444	adenylosuccinate lyase; Provisional; Region: PRK07492
1185652011445	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1185652011446	tetramer interface [polypeptide binding]; other site
1185652011447	active site
1185652011448	Predicted secreted protein (DUF2259); Region: DUF2259; pfam10016
1185652011449	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1185652011450	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1185652011451	substrate binding site [chemical binding]; other site
1185652011452	hexamer interface [polypeptide binding]; other site
1185652011453	metal binding site [ion binding]; metal-binding site
1185652011454	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
1185652011455	putative active site pocket [active]
1185652011456	cleavage site
1185652011457	DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603
1185652011458	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1185652011459	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
1185652011460	ligand binding site [chemical binding]; other site
1185652011461	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1185652011462	MoxR-like ATPases [General function prediction only]; Region: COG0714
1185652011463	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652011464	Walker A motif; other site
1185652011465	ATP binding site [chemical binding]; other site
1185652011466	Walker B motif; other site
1185652011467	arginine finger; other site
1185652011468	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
1185652011469	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1185652011470	metal ion-dependent adhesion site (MIDAS); other site
1185652011471	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1185652011472	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1185652011473	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1185652011474	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1185652011475	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
1185652011476	putative MPT binding site; other site
1185652011477	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1185652011478	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1185652011479	Ligand binding site; other site
1185652011480	metal-binding site
1185652011481	TfoX N-terminal domain; Region: TfoX_N; pfam04993
1185652011482	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1185652011483	nudix motif; other site
1185652011484	helicase 45; Provisional; Region: PTZ00424
1185652011485	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1185652011486	ATP binding site [chemical binding]; other site
1185652011487	Mg++ binding site [ion binding]; other site
1185652011488	motif III; other site
1185652011489	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1185652011490	nucleotide binding region [chemical binding]; other site
1185652011491	ATP-binding site [chemical binding]; other site
1185652011492	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1185652011493	Peptidase family M23; Region: Peptidase_M23; pfam01551
1185652011494	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1185652011495	dinuclear metal binding motif [ion binding]; other site
1185652011496	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1185652011497	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1185652011498	catalytic triad [active]
1185652011499	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1185652011500	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1185652011501	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1185652011502	active site
1185652011503	HIGH motif; other site
1185652011504	dimer interface [polypeptide binding]; other site
1185652011505	KMSKS motif; other site
1185652011506	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1185652011507	RNA binding surface [nucleotide binding]; other site
1185652011508	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
1185652011509	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652011510	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652011511	metal binding site [ion binding]; metal-binding site
1185652011512	active site
1185652011513	I-site; other site
1185652011514	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
1185652011515	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1185652011516	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1185652011517	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1185652011518	catalytic residue [active]
1185652011519	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
1185652011520	putative ABC transporter; Region: ycf24; CHL00085
1185652011521	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1185652011522	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1185652011523	Walker A/P-loop; other site
1185652011524	ATP binding site [chemical binding]; other site
1185652011525	Q-loop/lid; other site
1185652011526	ABC transporter signature motif; other site
1185652011527	Walker B; other site
1185652011528	D-loop; other site
1185652011529	H-loop/switch region; other site
1185652011530	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1185652011531	FeS assembly protein SufD; Region: sufD; TIGR01981
1185652011532	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1185652011533	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1185652011534	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1185652011535	catalytic residue [active]
1185652011536	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
1185652011537	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
1185652011538	glycine dehydrogenase; Provisional; Region: PRK05367
1185652011539	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1185652011540	tetramer interface [polypeptide binding]; other site
1185652011541	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652011542	catalytic residue [active]
1185652011543	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1185652011544	tetramer interface [polypeptide binding]; other site
1185652011545	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652011546	catalytic residue [active]
1185652011547	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1185652011548	lipoyl attachment site [posttranslational modification]; other site
1185652011549	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
1185652011550	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1185652011551	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
1185652011552	Copper(I)-binding protein [Inorganic ion transport and    metabolism]; Region: COG2847
1185652011553	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1185652011554	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
1185652011555	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1185652011556	active site
1185652011557	homotetramer interface [polypeptide binding]; other site
1185652011558	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652011559	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
1185652011560	active site
1185652011561	motif I; other site
1185652011562	motif II; other site
1185652011563	TniQ; Region: TniQ; pfam06527
1185652011564	AAA domain; Region: AAA_22; pfam13401
1185652011565	Bacterial TniB protein; Region: TniB; pfam05621
1185652011566	Integrase core domain; Region: rve; pfam00665
1185652011567	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
1185652011568	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1185652011569	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1185652011570	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1185652011571	putative active site [active]
1185652011572	Predicted membrane protein [Function unknown]; Region: COG3619
1185652011573	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1185652011574	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1185652011575	NAD binding site [chemical binding]; other site
1185652011576	substrate binding site [chemical binding]; other site
1185652011577	catalytic Zn binding site [ion binding]; other site
1185652011578	tetramer interface [polypeptide binding]; other site
1185652011579	structural Zn binding site [ion binding]; other site
1185652011580	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1185652011581	putative protease; Provisional; Region: PRK15447
1185652011582	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1185652011583	Peptidase family U32; Region: Peptidase_U32; pfam01136
1185652011584	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
1185652011585	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
1185652011586	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
1185652011587	Flavoprotein; Region: Flavoprotein; pfam02441
1185652011588	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
1185652011589	Predicted membrane protein [Function unknown]; Region: COG4094
1185652011590	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
1185652011591	Subunit I/III interface [polypeptide binding]; other site
1185652011592	Cytochrome c; Region: Cytochrom_C; pfam00034
1185652011593	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
1185652011594	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
1185652011595	D-pathway; other site
1185652011596	K-pathway; other site
1185652011597	Binuclear center (active site) [active]
1185652011598	Putative proton exit pathway; other site
1185652011599	MoxR-like ATPases [General function prediction only]; Region: COG0714
1185652011600	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652011601	Walker A motif; other site
1185652011602	ATP binding site [chemical binding]; other site
1185652011603	Walker B motif; other site
1185652011604	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
1185652011605	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
1185652011606	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
1185652011607	metal ion-dependent adhesion site (MIDAS); other site
1185652011608	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
1185652011609	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1185652011610	FeS/SAM binding site; other site
1185652011611	HemN C-terminal domain; Region: HemN_C; pfam06969
1185652011612	Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719
1185652011613	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
1185652011614	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
1185652011615	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1185652011616	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1185652011617	Cytochrome P450; Region: p450; cl12078
1185652011618	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
1185652011619	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
1185652011620	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
1185652011621	Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213
1185652011622	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
1185652011623	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1185652011624	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1185652011625	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1185652011626	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1185652011627	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1185652011628	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1185652011629	ligand binding site [chemical binding]; other site
1185652011630	flexible hinge region; other site
1185652011631	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1185652011632	putative switch regulator; other site
1185652011633	non-specific DNA interactions [nucleotide binding]; other site
1185652011634	DNA binding site [nucleotide binding]
1185652011635	sequence specific DNA binding site [nucleotide binding]; other site
1185652011636	putative cAMP binding site [chemical binding]; other site
1185652011637	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
1185652011638	pseudoazurin; Region: pseudoazurin; TIGR02375
1185652011639	Periplasmic nitrate reductase system, NapE component [Energy production and conversion]; Region: NapE; COG4459
1185652011640	ferredoxin-type protein; Provisional; Region: PRK10194
1185652011641	4Fe-4S binding domain; Region: Fer4; cl02805
1185652011642	Uncharacterized protein involved in formation of periplasmic nitrate reductase [Inorganic ion transport and metabolism]; Region: NapD; COG3062
1185652011643	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
1185652011644	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1185652011645	[4Fe-4S] binding site [ion binding]; other site
1185652011646	molybdopterin cofactor binding site; other site
1185652011647	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1185652011648	molybdopterin cofactor binding site; other site
1185652011649	Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043
1185652011650	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
1185652011651	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
1185652011652	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1185652011653	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1185652011654	Ligand Binding Site [chemical binding]; other site
1185652011655	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1185652011656	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1185652011657	ligand binding site [chemical binding]; other site
1185652011658	flexible hinge region; other site
1185652011659	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1185652011660	putative switch regulator; other site
1185652011661	non-specific DNA interactions [nucleotide binding]; other site
1185652011662	DNA binding site [nucleotide binding]
1185652011663	sequence specific DNA binding site [nucleotide binding]; other site
1185652011664	putative cAMP binding site [chemical binding]; other site
1185652011665	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
1185652011666	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
1185652011667	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
1185652011668	Low-spin heme binding site [chemical binding]; other site
1185652011669	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
1185652011670	Putative water exit pathway; other site
1185652011671	Binuclear center (active site) [active]
1185652011672	Putative proton exit pathway; other site
1185652011673	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
1185652011674	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
1185652011675	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
1185652011676	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
1185652011677	Cytochrome c; Region: Cytochrom_C; pfam00034
1185652011678	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1185652011679	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
1185652011680	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1185652011681	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
1185652011682	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
1185652011683	FixH; Region: FixH; pfam05751
1185652011684	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1185652011685	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1185652011686	metal-binding site [ion binding]
1185652011687	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1185652011688	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
1185652011689	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1185652011690	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1185652011691	ligand binding site [chemical binding]; other site
1185652011692	flexible hinge region; other site
1185652011693	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1185652011694	putative switch regulator; other site
1185652011695	non-specific DNA interactions [nucleotide binding]; other site
1185652011696	DNA binding site [nucleotide binding]
1185652011697	sequence specific DNA binding site [nucleotide binding]; other site
1185652011698	putative cAMP binding site [chemical binding]; other site
1185652011699	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1185652011700	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
1185652011701	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
1185652011702	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
1185652011703	Fe2+ transport protein; Region: Iron_transport; pfam10634
1185652011704	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1185652011705	PAS domain S-box; Region: sensory_box; TIGR00229
1185652011706	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652011707	putative active site [active]
1185652011708	heme pocket [chemical binding]; other site
1185652011709	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652011710	dimer interface [polypeptide binding]; other site
1185652011711	phosphorylation site [posttranslational modification]
1185652011712	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652011713	ATP binding site [chemical binding]; other site
1185652011714	Mg2+ binding site [ion binding]; other site
1185652011715	G-X-G motif; other site
1185652011716	response regulator FixJ; Provisional; Region: fixJ; PRK09390
1185652011717	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652011718	active site
1185652011719	phosphorylation site [posttranslational modification]
1185652011720	intermolecular recognition site; other site
1185652011721	dimerization interface [polypeptide binding]; other site
1185652011722	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652011723	DNA binding residues [nucleotide binding]
1185652011724	dimerization interface [polypeptide binding]; other site
1185652011725	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1185652011726	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1185652011727	ligand binding site [chemical binding]; other site
1185652011728	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1185652011729	putative switch regulator; other site
1185652011730	non-specific DNA interactions [nucleotide binding]; other site
1185652011731	DNA binding site [nucleotide binding]
1185652011732	sequence specific DNA binding site [nucleotide binding]; other site
1185652011733	putative cAMP binding site [chemical binding]; other site
1185652011734	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
1185652011735	Regulator of cell morphogenesis and NO signaling [Cell division and chromosome partitioning]; Region: COG2846
1185652011736	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
1185652011737	Hemerythrin-like domain; Region: Hr-like; cd12108
1185652011738	Fe binding site [ion binding]; other site
1185652011739	NnrS protein; Region: NnrS; cl01258
1185652011740	PRC-barrel domain; Region: PRC; pfam05239
1185652011741	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1185652011742	ApbE family; Region: ApbE; pfam02424
1185652011743	Predicted lipoprotein involved in nitrous oxide reduction [Energy production and conversion]; Region: NosL; COG4314
1185652011744	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1185652011745	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1185652011746	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1185652011747	Walker A/P-loop; other site
1185652011748	ATP binding site [chemical binding]; other site
1185652011749	Q-loop/lid; other site
1185652011750	ABC transporter signature motif; other site
1185652011751	Walker B; other site
1185652011752	D-loop; other site
1185652011753	H-loop/switch region; other site
1185652011754	Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420
1185652011755	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
1185652011756	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
1185652011757	nitrous-oxide reductase; Validated; Region: PRK02888
1185652011758	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1185652011759	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
1185652011760	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
1185652011761	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1185652011762	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1185652011763	Uncharacterized conserved protein [Function unknown]; Region: COG1633
1185652011764	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
1185652011765	diiron binding motif [ion binding]; other site
1185652011766	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1185652011767	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1185652011768	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1185652011769	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
1185652011770	cofactor binding site; other site
1185652011771	DNA binding site [nucleotide binding]
1185652011772	substrate interaction site [chemical binding]; other site
1185652011773	DNA methylase; Region: N6_N4_Mtase; cl17433
1185652011774	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1185652011775	active site
1185652011776	NTP binding site [chemical binding]; other site
1185652011777	metal binding triad [ion binding]; metal-binding site
1185652011778	antibiotic binding site [chemical binding]; other site
1185652011779	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652011780	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1185652011781	NAD(P) binding site [chemical binding]; other site
1185652011782	active site
1185652011783	Restriction endonuclease; Region: Mrr_cat; pfam04471
1185652011784	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1185652011785	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
1185652011786	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1185652011787	active site
1185652011788	NTP binding site [chemical binding]; other site
1185652011789	metal binding triad [ion binding]; metal-binding site
1185652011790	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1185652011791	active site
1185652011792	DNA polymerase IV; Validated; Region: PRK02406
1185652011793	DNA binding site [nucleotide binding]
1185652011794	Staphylococcal nuclease homologues; Region: SNc; smart00318
1185652011795	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1185652011796	Catalytic site; other site
1185652011797	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1185652011798	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1185652011799	active site
1185652011800	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1185652011801	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1185652011802	ATP binding site [chemical binding]; other site
1185652011803	putative Mg++ binding site [ion binding]; other site
1185652011804	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1185652011805	nucleotide binding region [chemical binding]; other site
1185652011806	ATP-binding site [chemical binding]; other site
1185652011807	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652011808	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1185652011809	Walker A motif; other site
1185652011810	ATP binding site [chemical binding]; other site
1185652011811	Walker B motif; other site
1185652011812	arginine finger; other site
1185652011813	Peptidase family M41; Region: Peptidase_M41; pfam01434
1185652011814	Predicted transporter component [General function prediction only]; Region: COG2391
1185652011815	Sulphur transport; Region: Sulf_transp; pfam04143
1185652011816	Predicted transporter component [General function prediction only]; Region: COG2391
1185652011817	Sulphur transport; Region: Sulf_transp; pfam04143
1185652011818	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1185652011819	Cytochrome c; Region: Cytochrom_C; cl11414
1185652011820	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1185652011821	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1185652011822	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1185652011823	TAP-like protein; Region: Abhydrolase_4; pfam08386
1185652011824	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1185652011825	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1185652011826	Hemerythrin-like domain; Region: Hr-like; cd12108
1185652011827	Fe binding site [ion binding]; other site
1185652011828	Predicted membrane protein [Function unknown]; Region: COG3619
1185652011829	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
1185652011830	Predicted kinase [General function prediction only]; Region: COG0645
1185652011831	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1185652011832	active site
1185652011833	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1185652011834	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1185652011835	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1185652011836	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1185652011837	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652011838	motif II; other site
1185652011839	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1185652011840	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
1185652011841	BON domain; Region: BON; pfam04972
1185652011842	BON domain; Region: BON; pfam04972
1185652011843	BON domain; Region: BON; pfam04972
1185652011844	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
1185652011845	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1185652011846	Ligand Binding Site [chemical binding]; other site
1185652011847	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1185652011848	Ligand Binding Site [chemical binding]; other site
1185652011849	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
1185652011850	CoA binding domain; Region: CoA_binding_2; pfam13380
1185652011851	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
1185652011852	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
1185652011853	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1185652011854	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1185652011855	PAS domain S-box; Region: sensory_box; TIGR00229
1185652011856	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652011857	putative active site [active]
1185652011858	heme pocket [chemical binding]; other site
1185652011859	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1185652011860	dimer interface [polypeptide binding]; other site
1185652011861	phosphorylation site [posttranslational modification]
1185652011862	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652011863	ATP binding site [chemical binding]; other site
1185652011864	G-X-G motif; other site
1185652011865	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652011866	active site
1185652011867	phosphorylation site [posttranslational modification]
1185652011868	intermolecular recognition site; other site
1185652011869	dimerization interface [polypeptide binding]; other site
1185652011870	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1185652011871	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1185652011872	ligand binding site [chemical binding]; other site
1185652011873	flexible hinge region; other site
1185652011874	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1185652011875	putative switch regulator; other site
1185652011876	non-specific DNA interactions [nucleotide binding]; other site
1185652011877	DNA binding site [nucleotide binding]
1185652011878	sequence specific DNA binding site [nucleotide binding]; other site
1185652011879	putative cAMP binding site [chemical binding]; other site
1185652011880	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1185652011881	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652011882	active site
1185652011883	phosphorylation site [posttranslational modification]
1185652011884	intermolecular recognition site; other site
1185652011885	dimerization interface [polypeptide binding]; other site
1185652011886	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652011887	DNA binding site [nucleotide binding]
1185652011888	ornithine carbamoyltransferase; Validated; Region: PRK02102
1185652011889	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1185652011890	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1185652011891	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
1185652011892	Putative glucoamylase; Region: Glycoamylase; pfam10091
1185652011893	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
1185652011894	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1185652011895	Beta-Casp domain; Region: Beta-Casp; smart01027
1185652011896	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1185652011897	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1185652011898	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1185652011899	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1185652011900	protein binding site [polypeptide binding]; other site
1185652011901	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1185652011902	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1185652011903	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652011904	FtsX-like permease family; Region: FtsX; pfam02687
1185652011905	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1185652011906	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1185652011907	FtsX-like permease family; Region: FtsX; pfam02687
1185652011908	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1185652011909	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1185652011910	Walker A/P-loop; other site
1185652011911	ATP binding site [chemical binding]; other site
1185652011912	Q-loop/lid; other site
1185652011913	ABC transporter signature motif; other site
1185652011914	Walker B; other site
1185652011915	D-loop; other site
1185652011916	H-loop/switch region; other site
1185652011917	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1185652011918	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1185652011919	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1185652011920	hydrophobic ligand binding site; other site
1185652011921	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1185652011922	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1185652011923	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1185652011924	FOG: CBS domain [General function prediction only]; Region: COG0517
1185652011925	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
1185652011926	Acetokinase family; Region: Acetate_kinase; cl17229
1185652011927	propionate/acetate kinase; Provisional; Region: PRK12379
1185652011928	putative phosphoketolase; Provisional; Region: PRK05261
1185652011929	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
1185652011930	TPP-binding site; other site
1185652011931	XFP C-terminal domain; Region: XFP_C; pfam09363
1185652011932	LTXXQ motif family protein; Region: LTXXQ; pfam07813
1185652011933	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1185652011934	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1185652011935	active site
1185652011936	metal binding site [ion binding]; metal-binding site
1185652011937	DNA binding site [nucleotide binding]
1185652011938	P-loop containing region of AAA domain; Region: AAA_29; cl17516
1185652011939	AAA domain; Region: AAA_27; pfam13514
1185652011940	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
1185652011941	AAA domain; Region: AAA_21; pfam13304
1185652011942	Caspase domain; Region: Peptidase_C14; pfam00656
1185652011943	ski2-like helicase; Provisional; Region: PRK02362
1185652011944	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1185652011945	ATP binding site [chemical binding]; other site
1185652011946	putative Mg++ binding site [ion binding]; other site
1185652011947	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1185652011948	nucleotide binding region [chemical binding]; other site
1185652011949	ATP-binding site [chemical binding]; other site
1185652011950	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
1185652011951	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
1185652011952	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1185652011953	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
1185652011954	active site
1185652011955	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1185652011956	TSCPD domain; Region: TSCPD; pfam12637
1185652011957	Uncharacterized conserved protein [Function unknown]; Region: COG1801
1185652011958	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1185652011959	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1185652011960	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1185652011961	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1185652011962	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1185652011963	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1185652011964	dimer interface [polypeptide binding]; other site
1185652011965	ssDNA binding site [nucleotide binding]; other site
1185652011966	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1185652011967	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
1185652011968	DNA gyrase subunit A; Validated; Region: PRK05560
1185652011969	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1185652011970	CAP-like domain; other site
1185652011971	active site
1185652011972	primary dimer interface [polypeptide binding]; other site
1185652011973	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1185652011974	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1185652011975	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1185652011976	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1185652011977	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1185652011978	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1185652011979	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1185652011980	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1185652011981	catalytic residue [active]
1185652011982	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652011983	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652011984	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1185652011985	putative effector binding pocket; other site
1185652011986	dimerization interface [polypeptide binding]; other site
1185652011987	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1185652011988	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1185652011989	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652011990	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652011991	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652011992	putative DNA binding site [nucleotide binding]; other site
1185652011993	putative Zn2+ binding site [ion binding]; other site
1185652011994	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652011995	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1185652011996	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1185652011997	putative metal binding site; other site
1185652011998	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1185652011999	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1185652012000	putative ADP-binding pocket [chemical binding]; other site
1185652012001	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1185652012002	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1185652012003	putative ADP-binding pocket [chemical binding]; other site
1185652012004	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1185652012005	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1185652012006	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1185652012007	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1185652012008	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1185652012009	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652012010	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1185652012011	putative substrate translocation pore; other site
1185652012012	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1185652012013	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1185652012014	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1185652012015	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1185652012016	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1185652012017	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1185652012018	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1185652012019	IMP binding site; other site
1185652012020	dimer interface [polypeptide binding]; other site
1185652012021	partial ornithine binding site; other site
1185652012022	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1185652012023	L-threonine dehydrogenase; Region: threonine_DH_like; cd08234
1185652012024	putative NAD(P) binding site [chemical binding]; other site
1185652012025	catalytic Zn binding site [ion binding]; other site
1185652012026	Predicted metalloprotease [General function prediction only]; Region: COG2321
1185652012027	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1185652012028	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1185652012029	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1185652012030	active site
1185652012031	catalytic tetrad [active]
1185652012032	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652012033	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
1185652012034	putative effector binding pocket; other site
1185652012035	putative dimerization interface [polypeptide binding]; other site
1185652012036	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652012037	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1185652012038	putative substrate translocation pore; other site
1185652012039	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1185652012040	putative efflux protein, MATE family; Region: matE; TIGR00797
1185652012041	cation binding site [ion binding]; other site
1185652012042	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1185652012043	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1185652012044	active site
1185652012045	(T/H)XGH motif; other site
1185652012046	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1185652012047	active site
1185652012048	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1185652012049	active site
1185652012050	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1185652012051	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1185652012052	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1185652012053	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1185652012054	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1185652012055	classical (c) SDRs; Region: SDR_c; cd05233
1185652012056	NAD(P) binding site [chemical binding]; other site
1185652012057	active site
1185652012058	SEC-C motif; Region: SEC-C; pfam02810
1185652012059	2-oxoisovalerate dehydrogenase E2 component; Region: PLN02528
1185652012060	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1185652012061	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1185652012062	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1185652012063	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1185652012064	classical (c) SDRs; Region: SDR_c; cd05233
1185652012065	NAD(P) binding site [chemical binding]; other site
1185652012066	active site
1185652012067	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
1185652012068	Predicted integral membrane protein [Function unknown]; Region: COG5616
1185652012069	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652012070	TPR motif; other site
1185652012071	binding surface
1185652012072	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652012073	TPR motif; other site
1185652012074	binding surface
1185652012075	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1185652012076	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
1185652012077	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1185652012078	conserved cys residue [active]
1185652012079	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652012080	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652012081	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1185652012082	active site residue [active]
1185652012083	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1185652012084	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652012085	Coenzyme A binding pocket [chemical binding]; other site
1185652012086	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1185652012087	Helix-turn-helix domain; Region: HTH_38; pfam13936
1185652012088	DNA-binding interface [nucleotide binding]; DNA binding site
1185652012089	Integrase core domain; Region: rve; pfam00665
1185652012090	Helix-turn-helix domain; Region: HTH_28; pfam13518
1185652012091	Winged helix-turn helix; Region: HTH_29; pfam13551
1185652012092	Homeodomain-like domain; Region: HTH_32; pfam13565
1185652012093	Integrase core domain; Region: rve; pfam00665
1185652012094	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1185652012095	putative hydrolase; Provisional; Region: PRK02113
1185652012096	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1185652012097	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1185652012098	active site
1185652012099	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
1185652012100	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1185652012101	active site
1185652012102	HIGH motif; other site
1185652012103	KMSKS motif; other site
1185652012104	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1185652012105	tRNA binding surface [nucleotide binding]; other site
1185652012106	anticodon binding site; other site
1185652012107	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria; Region: NTP-PPase_u1; cd11538
1185652012108	metal binding site [ion binding]; metal-binding site
1185652012109	DNA polymerase III subunit delta'; Validated; Region: PRK09112
1185652012110	AAA ATPase domain; Region: AAA_16; pfam13191
1185652012111	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1185652012112	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
1185652012113	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1185652012114	TMP-binding site; other site
1185652012115	ATP-binding site [chemical binding]; other site
1185652012116	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1185652012117	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1185652012118	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
1185652012119	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
1185652012120	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1185652012121	Uncharacterized conserved protein [Function unknown]; Region: COG5467
1185652012122	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1185652012123	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1185652012124	ATP binding site [chemical binding]; other site
1185652012125	active site
1185652012126	substrate binding site [chemical binding]; other site
1185652012127	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
1185652012128	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1185652012129	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1185652012130	putative active site [active]
1185652012131	catalytic triad [active]
1185652012132	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1185652012133	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652012134	DNA-binding site [nucleotide binding]; DNA binding site
1185652012135	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652012136	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652012137	homodimer interface [polypeptide binding]; other site
1185652012138	catalytic residue [active]
1185652012139	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
1185652012140	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1185652012141	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1185652012142	dimerization interface [polypeptide binding]; other site
1185652012143	ATP binding site [chemical binding]; other site
1185652012144	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1185652012145	dimerization interface [polypeptide binding]; other site
1185652012146	ATP binding site [chemical binding]; other site
1185652012147	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
1185652012148	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
1185652012149	putative GSH binding site [chemical binding]; other site
1185652012150	catalytic residues [active]
1185652012151	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652012152	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1185652012153	putative substrate translocation pore; other site
1185652012154	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1185652012155	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652012156	putative substrate translocation pore; other site
1185652012157	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
1185652012158	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1185652012159	active site
1185652012160	putative lithium-binding site [ion binding]; other site
1185652012161	substrate binding site [chemical binding]; other site
1185652012162	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
1185652012163	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
1185652012164	Ligand Binding Site [chemical binding]; other site
1185652012165	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1185652012166	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1185652012167	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1185652012168	RNA binding surface [nucleotide binding]; other site
1185652012169	Domain of unknown function DUF87; Region: DUF87; pfam01935
1185652012170	HerA helicase [Replication, recombination, and repair]; Region: COG0433
1185652012171	glutamate racemase; Provisional; Region: PRK00865
1185652012172	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
1185652012173	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1185652012174	isocitrate dehydrogenase; Validated; Region: PRK08299
1185652012175	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
1185652012176	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1185652012177	Helix-turn-helix domain; Region: HTH_18; pfam12833
1185652012178	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652012179	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
1185652012180	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1185652012181	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1185652012182	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1185652012183	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1185652012184	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1185652012185	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1185652012186	motif 1; other site
1185652012187	active site
1185652012188	motif 2; other site
1185652012189	motif 3; other site
1185652012190	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1185652012191	recombinase A; Provisional; Region: recA; PRK09354
1185652012192	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1185652012193	hexamer interface [polypeptide binding]; other site
1185652012194	Walker A motif; other site
1185652012195	ATP binding site [chemical binding]; other site
1185652012196	Walker B motif; other site
1185652012197	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
1185652012198	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1185652012199	substrate binding site [chemical binding]; other site
1185652012200	ATP binding site [chemical binding]; other site
1185652012201	Uncharacterized enzyme involved in pigment biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IndA; COG2313
1185652012202	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1185652012203	PAS domain; Region: PAS_9; pfam13426
1185652012204	putative active site [active]
1185652012205	heme pocket [chemical binding]; other site
1185652012206	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1185652012207	PAS domain; Region: PAS; smart00091
1185652012208	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652012209	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652012210	dimer interface [polypeptide binding]; other site
1185652012211	phosphorylation site [posttranslational modification]
1185652012212	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652012213	ATP binding site [chemical binding]; other site
1185652012214	Mg2+ binding site [ion binding]; other site
1185652012215	G-X-G motif; other site
1185652012216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652012217	Response regulator receiver domain; Region: Response_reg; pfam00072
1185652012218	active site
1185652012219	phosphorylation site [posttranslational modification]
1185652012220	intermolecular recognition site; other site
1185652012221	dimerization interface [polypeptide binding]; other site
1185652012222	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
1185652012223	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1185652012224	catalytic core [active]
1185652012225	YcjX-like family, DUF463; Region: DUF463; cl01193
1185652012226	Predicted membrane protein [Function unknown]; Region: COG3768
1185652012227	Domain of unknown function (DUF697); Region: DUF697; cl12064
1185652012228	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1185652012229	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1185652012230	catalytic center binding site [active]
1185652012231	ATP binding site [chemical binding]; other site
1185652012232	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1185652012233	homooctamer interface [polypeptide binding]; other site
1185652012234	active site
1185652012235	dihydropteroate synthase; Region: DHPS; TIGR01496
1185652012236	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1185652012237	substrate binding pocket [chemical binding]; other site
1185652012238	dimer interface [polypeptide binding]; other site
1185652012239	inhibitor binding site; inhibition site
1185652012240	Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5661
1185652012241	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1185652012242	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1185652012243	catalytic loop [active]
1185652012244	iron binding site [ion binding]; other site
1185652012245	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652012246	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
1185652012247	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
1185652012248	cytochrome b; Provisional; Region: CYTB; MTH00191
1185652012249	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
1185652012250	Qi binding site; other site
1185652012251	intrachain domain interface; other site
1185652012252	interchain domain interface [polypeptide binding]; other site
1185652012253	heme bH binding site [chemical binding]; other site
1185652012254	heme bL binding site [chemical binding]; other site
1185652012255	Qo binding site; other site
1185652012256	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
1185652012257	interchain domain interface [polypeptide binding]; other site
1185652012258	intrachain domain interface; other site
1185652012259	Qi binding site; other site
1185652012260	Qo binding site; other site
1185652012261	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
1185652012262	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
1185652012263	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
1185652012264	[2Fe-2S] cluster binding site [ion binding]; other site
1185652012265	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
1185652012266	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1185652012267	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1185652012268	Walker A/P-loop; other site
1185652012269	ATP binding site [chemical binding]; other site
1185652012270	Q-loop/lid; other site
1185652012271	ABC transporter signature motif; other site
1185652012272	Walker B; other site
1185652012273	D-loop; other site
1185652012274	H-loop/switch region; other site
1185652012275	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1185652012276	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1185652012277	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652012278	Walker A/P-loop; other site
1185652012279	ATP binding site [chemical binding]; other site
1185652012280	Q-loop/lid; other site
1185652012281	ABC transporter signature motif; other site
1185652012282	Walker B; other site
1185652012283	D-loop; other site
1185652012284	H-loop/switch region; other site
1185652012285	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1185652012286	Predicted flavoprotein [General function prediction only]; Region: COG0431
1185652012287	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1185652012288	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
1185652012289	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
1185652012290	DNA binding residues [nucleotide binding]
1185652012291	dimer interface [polypeptide binding]; other site
1185652012292	[2Fe-2S] cluster binding site [ion binding]; other site
1185652012293	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
1185652012294	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
1185652012295	BON domain; Region: BON; pfam04972
1185652012296	ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218
1185652012297	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
1185652012298	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1185652012299	mce related protein; Region: MCE; pfam02470
1185652012300	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1185652012301	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1185652012302	Walker A/P-loop; other site
1185652012303	ATP binding site [chemical binding]; other site
1185652012304	Q-loop/lid; other site
1185652012305	ABC transporter signature motif; other site
1185652012306	Walker B; other site
1185652012307	D-loop; other site
1185652012308	H-loop/switch region; other site
1185652012309	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1185652012310	Permease; Region: Permease; pfam02405
1185652012311	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
1185652012312	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
1185652012313	active site
1185652012314	MFS_1 like family; Region: MFS_1_like; pfam12832
1185652012315	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
1185652012316	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1185652012317	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1185652012318	putative active site [active]
1185652012319	putative metal binding site [ion binding]; other site
1185652012320	malic enzyme; Reviewed; Region: PRK12862
1185652012321	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1185652012322	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1185652012323	putative NAD(P) binding site [chemical binding]; other site
1185652012324	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1185652012325	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1185652012326	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652012327	DNA binding residues [nucleotide binding]
1185652012328	dimerization interface [polypeptide binding]; other site
1185652012329	N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916
1185652012330	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
1185652012331	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
1185652012332	putative FMN binding site [chemical binding]; other site
1185652012333	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
1185652012334	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1185652012335	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1185652012336	NAD synthetase; Provisional; Region: PRK13981
1185652012337	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
1185652012338	multimer interface [polypeptide binding]; other site
1185652012339	active site
1185652012340	catalytic triad [active]
1185652012341	protein interface 1 [polypeptide binding]; other site
1185652012342	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1185652012343	homodimer interface [polypeptide binding]; other site
1185652012344	NAD binding pocket [chemical binding]; other site
1185652012345	ATP binding pocket [chemical binding]; other site
1185652012346	Mg binding site [ion binding]; other site
1185652012347	active-site loop [active]
1185652012348	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1185652012349	Sulfatase; Region: Sulfatase; pfam00884
1185652012350	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1185652012351	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
1185652012352	glutathione reductase; Validated; Region: PRK06116
1185652012353	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1185652012354	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652012355	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1185652012356	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184
1185652012357	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1185652012358	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1185652012359	active site
1185652012360	dimer interface [polypeptide binding]; other site
1185652012361	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1185652012362	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1185652012363	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652012364	motif II; other site
1185652012365	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1185652012366	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
1185652012367	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1185652012368	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1185652012369	Class II fumarases; Region: Fumarase_classII; cd01362
1185652012370	active site
1185652012371	tetramer interface [polypeptide binding]; other site
1185652012372	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652012373	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652012374	metal binding site [ion binding]; metal-binding site
1185652012375	active site
1185652012376	I-site; other site
1185652012377	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
1185652012378	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1185652012379	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1185652012380	MarR family; Region: MarR_2; pfam12802
1185652012381	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
1185652012382	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
1185652012383	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1185652012384	FeS/SAM binding site; other site
1185652012385	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1185652012386	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1185652012387	dimerization interface [polypeptide binding]; other site
1185652012388	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1185652012389	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1185652012390	dimer interface [polypeptide binding]; other site
1185652012391	putative CheW interface [polypeptide binding]; other site
1185652012392	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1185652012393	EamA-like transporter family; Region: EamA; pfam00892
1185652012394	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1185652012395	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1185652012396	GTP binding site; other site
1185652012397	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
1185652012398	Walker A motif; other site
1185652012399	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1185652012400	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1185652012401	ligand binding site [chemical binding]; other site
1185652012402	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1185652012403	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652012404	substrate binding pocket [chemical binding]; other site
1185652012405	membrane-bound complex binding site; other site
1185652012406	hinge residues; other site
1185652012407	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1185652012408	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652012409	dimer interface [polypeptide binding]; other site
1185652012410	conserved gate region; other site
1185652012411	putative PBP binding loops; other site
1185652012412	ABC-ATPase subunit interface; other site
1185652012413	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1185652012414	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652012415	dimer interface [polypeptide binding]; other site
1185652012416	conserved gate region; other site
1185652012417	putative PBP binding loops; other site
1185652012418	ABC-ATPase subunit interface; other site
1185652012419	Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425
1185652012420	Predicted integral membrane protein [Function unknown]; Region: COG5530
1185652012421	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
1185652012422	Tetratricopeptide repeat; Region: TPR_1; pfam00515
1185652012423	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652012424	S-adenosylmethionine binding site [chemical binding]; other site
1185652012425	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1185652012426	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1185652012427	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1185652012428	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1185652012429	active site
1185652012430	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652012431	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652012432	putative DNA binding site [nucleotide binding]; other site
1185652012433	putative Zn2+ binding site [ion binding]; other site
1185652012434	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652012435	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
1185652012436	putative uracil binding site [chemical binding]; other site
1185652012437	putative active site [active]
1185652012438	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652012439	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652012440	dimer interface [polypeptide binding]; other site
1185652012441	phosphorylation site [posttranslational modification]
1185652012442	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652012443	ATP binding site [chemical binding]; other site
1185652012444	Mg2+ binding site [ion binding]; other site
1185652012445	G-X-G motif; other site
1185652012446	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1185652012447	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1185652012448	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1185652012449	putative dimer interface [polypeptide binding]; other site
1185652012450	active site pocket [active]
1185652012451	putative cataytic base [active]
1185652012452	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1185652012453	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
1185652012454	Predicted aspartyl protease [General function prediction only]; Region: COG3577
1185652012455	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
1185652012456	catalytic motif [active]
1185652012457	Catalytic residue [active]
1185652012458	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1185652012459	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1185652012460	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1185652012461	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1185652012462	Walker A/P-loop; other site
1185652012463	ATP binding site [chemical binding]; other site
1185652012464	Q-loop/lid; other site
1185652012465	ABC transporter signature motif; other site
1185652012466	Walker B; other site
1185652012467	D-loop; other site
1185652012468	H-loop/switch region; other site
1185652012469	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652012470	dimerization interface [polypeptide binding]; other site
1185652012471	putative DNA binding site [nucleotide binding]; other site
1185652012472	putative Zn2+ binding site [ion binding]; other site
1185652012473	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1185652012474	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
1185652012475	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
1185652012476	Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cl00097
1185652012477	Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cd00104
1185652012478	Cache domain; Region: Cache_2; pfam08269
1185652012479	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1185652012480	dimerization interface [polypeptide binding]; other site
1185652012481	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1185652012482	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1185652012483	dimer interface [polypeptide binding]; other site
1185652012484	putative CheW interface [polypeptide binding]; other site
1185652012485	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1185652012486	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3169
1185652012487	excinuclease ABC subunit B; Provisional; Region: PRK05298
1185652012488	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1185652012489	ATP binding site [chemical binding]; other site
1185652012490	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1185652012491	nucleotide binding region [chemical binding]; other site
1185652012492	ATP-binding site [chemical binding]; other site
1185652012493	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1185652012494	UvrB/uvrC motif; Region: UVR; pfam02151
1185652012495	DnaJ domain; Region: DnaJ; pfam00226
1185652012496	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1185652012497	DNA-binding site [nucleotide binding]; DNA binding site
1185652012498	RNA-binding motif; other site
1185652012499	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
1185652012500	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1185652012501	FMN binding site [chemical binding]; other site
1185652012502	active site
1185652012503	catalytic residues [active]
1185652012504	substrate binding site [chemical binding]; other site
1185652012505	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1185652012506	active site
1185652012507	DNA binding site [nucleotide binding]
1185652012508	Int/Topo IB signature motif; other site
1185652012509	Beta protein; Region: Beta_protein; pfam14350
1185652012510	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1185652012511	active site
1185652012512	DNA binding site [nucleotide binding]
1185652012513	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1185652012514	DNA binding site [nucleotide binding]
1185652012515	Protein of unknown function (DUF982); Region: DUF982; pfam06169
1185652012516	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1185652012517	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1185652012518	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1185652012519	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1185652012520	trimer interface [polypeptide binding]; other site
1185652012521	putative metal binding site [ion binding]; other site
1185652012522	Phytochelatin synthase; Region: Phytochelatin; pfam05023
1185652012523	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1185652012524	metal binding site 2 [ion binding]; metal-binding site
1185652012525	putative DNA binding helix; other site
1185652012526	metal binding site 1 [ion binding]; metal-binding site
1185652012527	dimer interface [polypeptide binding]; other site
1185652012528	structural Zn2+ binding site [ion binding]; other site
1185652012529	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1185652012530	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1185652012531	ABC-ATPase subunit  interface; other site
1185652012532	dimer interface [polypeptide binding]; other site
1185652012533	putative PBP binding regions; other site
1185652012534	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1185652012535	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1185652012536	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
1185652012537	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
1185652012538	metal binding site [ion binding]; metal-binding site
1185652012539	Predicted integral membrane protein [Function unknown]; Region: COG5455
1185652012540	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1185652012541	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
1185652012542	inhibitor binding site; inhibition site
1185652012543	active site
1185652012544	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
1185652012545	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
1185652012546	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1185652012547	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
1185652012548	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
1185652012549	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1185652012550	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1185652012551	active site
1185652012552	catalytic tetrad [active]
1185652012553	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652012554	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652012555	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1185652012556	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
1185652012557	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1185652012558	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1185652012559	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1185652012560	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652012561	Walker A/P-loop; other site
1185652012562	ATP binding site [chemical binding]; other site
1185652012563	Q-loop/lid; other site
1185652012564	ABC transporter signature motif; other site
1185652012565	Walker B; other site
1185652012566	D-loop; other site
1185652012567	H-loop/switch region; other site
1185652012568	TOBE domain; Region: TOBE; pfam03459
1185652012569	TOBE domain; Region: TOBE_2; pfam08402
1185652012570	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652012571	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652012572	dimer interface [polypeptide binding]; other site
1185652012573	conserved gate region; other site
1185652012574	putative PBP binding loops; other site
1185652012575	ABC-ATPase subunit interface; other site
1185652012576	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652012577	dimer interface [polypeptide binding]; other site
1185652012578	conserved gate region; other site
1185652012579	putative PBP binding loops; other site
1185652012580	ABC-ATPase subunit interface; other site
1185652012581	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652012582	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652012583	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652012584	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652012585	DNA binding site [nucleotide binding]
1185652012586	domain linker motif; other site
1185652012587	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
1185652012588	ligand binding site [chemical binding]; other site
1185652012589	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1185652012590	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1185652012591	6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362
1185652012592	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1185652012593	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1185652012594	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
1185652012595	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652012596	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1185652012597	PAS fold; Region: PAS_4; pfam08448
1185652012598	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1185652012599	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1185652012600	putative acyl-acceptor binding pocket; other site
1185652012601	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1185652012602	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1185652012603	NAD(P) binding site [chemical binding]; other site
1185652012604	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
1185652012605	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1185652012606	dimer interface [polypeptide binding]; other site
1185652012607	active site
1185652012608	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
1185652012609	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1185652012610	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1185652012611	active site
1185652012612	active site
1185652012613	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764
1185652012614	active site 2 [active]
1185652012615	active site 1 [active]
1185652012616	acyl carrier protein; Provisional; Region: PRK06508
1185652012617	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1185652012618	active site
1185652012619	catalytic site [active]
1185652012620	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
1185652012621	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
1185652012622	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652012623	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652012624	homodimer interface [polypeptide binding]; other site
1185652012625	catalytic residue [active]
1185652012626	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1185652012627	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1185652012628	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1185652012629	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1185652012630	active site
1185652012631	SAM binding site [chemical binding]; other site
1185652012632	homodimer interface [polypeptide binding]; other site
1185652012633	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
1185652012634	hypothetical protein; Provisional; Region: PRK10621
1185652012635	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1185652012636	Phospholipid methyltransferase; Region: PEMT; cl17370
1185652012637	Phospholipid methyltransferase; Region: PEMT; cl17370
1185652012638	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
1185652012639	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1185652012640	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1185652012641	homodimer interface [polypeptide binding]; other site
1185652012642	Walker A motif; other site
1185652012643	ATP binding site [chemical binding]; other site
1185652012644	hydroxycobalamin binding site [chemical binding]; other site
1185652012645	Walker B motif; other site
1185652012646	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
1185652012647	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1185652012648	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
1185652012649	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1185652012650	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
1185652012651	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1185652012652	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1185652012653	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1185652012654	homotrimer interface [polypeptide binding]; other site
1185652012655	Walker A motif; other site
1185652012656	GTP binding site [chemical binding]; other site
1185652012657	Walker B motif; other site
1185652012658	FecR protein; Region: FecR; pfam04773
1185652012659	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
1185652012660	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
1185652012661	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652012662	cyclase homology domain; Region: CHD; cd07302
1185652012663	nucleotidyl binding site; other site
1185652012664	metal binding site [ion binding]; metal-binding site
1185652012665	dimer interface [polypeptide binding]; other site
1185652012666	cobyric acid synthase; Provisional; Region: PRK00784
1185652012667	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1185652012668	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1185652012669	catalytic triad [active]
1185652012670	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1185652012671	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1185652012672	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1185652012673	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
1185652012674	Walker A/P-loop; other site
1185652012675	ATP binding site [chemical binding]; other site
1185652012676	Q-loop/lid; other site
1185652012677	ABC transporter signature motif; other site
1185652012678	Walker B; other site
1185652012679	D-loop; other site
1185652012680	H-loop/switch region; other site
1185652012681	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1185652012682	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652012683	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
1185652012684	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652012685	dimerization interface [polypeptide binding]; other site
1185652012686	methionine synthase I; Validated; Region: PRK07534
1185652012687	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1185652012688	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1185652012689	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1185652012690	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652012691	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652012692	homodimer interface [polypeptide binding]; other site
1185652012693	catalytic residue [active]
1185652012694	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1185652012695	YheO-like PAS domain; Region: PAS_6; pfam08348
1185652012696	HTH domain; Region: HTH_22; pfam13309
1185652012697	von Willebrand factor; Region: vWF_A; pfam12450
1185652012698	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
1185652012699	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
1185652012700	metal ion-dependent adhesion site (MIDAS); other site
1185652012701	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
1185652012702	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1185652012703	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1185652012704	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1185652012705	DNA binding residues [nucleotide binding]
1185652012706	Predicted periplasmic protein [Function unknown]; Region: COG3698
1185652012707	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1185652012708	Methylmalonic aciduria and homocystinuria type C protein and similar proteins; Region: MMACHC-like; cd12959
1185652012709	cobalamin binding site [chemical binding]; other site
1185652012710	Ferredoxin [Energy production and conversion]; Region: NapF; COG1145
1185652012711	Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253
1185652012712	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
1185652012713	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
1185652012714	B12 binding site [chemical binding]; other site
1185652012715	cobalt ligand [ion binding]; other site
1185652012716	Protein of unknown function (DUF1638); Region: DUF1638; pfam07796
1185652012717	Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653
1185652012718	putative active site [active]
1185652012719	putative cosubstrate binding site; other site
1185652012720	putative substrate binding site [chemical binding]; other site
1185652012721	catalytic site [active]
1185652012722	Virulence factor; Region: Virulence_fact; pfam13769
1185652012723	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
1185652012724	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1185652012725	FAD binding site [chemical binding]; other site
1185652012726	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
1185652012727	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535
1185652012728	substrate binding pocket [chemical binding]; other site
1185652012729	dimer interface [polypeptide binding]; other site
1185652012730	inhibitor binding site; inhibition site
1185652012731	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
1185652012732	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1185652012733	catalytic loop [active]
1185652012734	iron binding site [ion binding]; other site
1185652012735	Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891
1185652012736	putative hydrophobic ligand binding site [chemical binding]; other site
1185652012737	CLM binding site; other site
1185652012738	L1 loop; other site
1185652012739	DNA binding site [nucleotide binding]
1185652012740	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652012741	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652012742	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652012743	dimerization interface [polypeptide binding]; other site
1185652012744	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1185652012745	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
1185652012746	putative metal binding site [ion binding]; other site
1185652012747	putative homodimer interface [polypeptide binding]; other site
1185652012748	putative homotetramer interface [polypeptide binding]; other site
1185652012749	putative homodimer-homodimer interface [polypeptide binding]; other site
1185652012750	putative allosteric switch controlling residues; other site
1185652012751	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1185652012752	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1185652012753	conserved cys residue [active]
1185652012754	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652012755	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652012756	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1185652012757	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652012758	active site
1185652012759	phosphorylation site [posttranslational modification]
1185652012760	intermolecular recognition site; other site
1185652012761	dimerization interface [polypeptide binding]; other site
1185652012762	transcriptional regulator PhoB; Provisional; Region: PRK10161
1185652012763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652012764	active site
1185652012765	phosphorylation site [posttranslational modification]
1185652012766	intermolecular recognition site; other site
1185652012767	dimerization interface [polypeptide binding]; other site
1185652012768	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652012769	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652012770	metal binding site [ion binding]; metal-binding site
1185652012771	active site
1185652012772	I-site; other site
1185652012773	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1185652012774	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1185652012775	active site
1185652012776	phosphorylation site [posttranslational modification]
1185652012777	intermolecular recognition site; other site
1185652012778	dimerization interface [polypeptide binding]; other site
1185652012779	Response regulator receiver domain; Region: Response_reg; pfam00072
1185652012780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652012781	active site
1185652012782	phosphorylation site [posttranslational modification]
1185652012783	intermolecular recognition site; other site
1185652012784	dimerization interface [polypeptide binding]; other site
1185652012785	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652012786	cyclase homology domain; Region: CHD; cd07302
1185652012787	nucleotidyl binding site; other site
1185652012788	metal binding site [ion binding]; metal-binding site
1185652012789	dimer interface [polypeptide binding]; other site
1185652012790	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1185652012791	RibD C-terminal domain; Region: RibD_C; cl17279
1185652012792	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1185652012793	FOG: CBS domain [General function prediction only]; Region: COG0517
1185652012794	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
1185652012795	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
1185652012796	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1185652012797	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1185652012798	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1185652012799	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1185652012800	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1185652012801	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1185652012802	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1185652012803	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803
1185652012804	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1185652012805	transmembrane helices; other site
1185652012806	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1185652012807	TrkA-C domain; Region: TrkA_C; pfam02080
1185652012808	TrkA-C domain; Region: TrkA_C; pfam02080
1185652012809	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1185652012810	Protein of unknown function (DUF1515); Region: DUF1515; pfam07439
1185652012811	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1185652012812	catalytic residue [active]
1185652012813	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
1185652012814	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1185652012815	Terminase-like family; Region: Terminase_6; pfam03237
1185652012816	Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565
1185652012817	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1185652012818	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
1185652012819	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
1185652012820	BA14K-like protein; Region: BA14K; pfam07886
1185652012821	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
1185652012822	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1185652012823	DnaA box-binding interface [nucleotide binding]; other site
1185652012824	Predicted transcriptional regulator [Transcription]; Region: COG2932
1185652012825	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652012826	non-specific DNA binding site [nucleotide binding]; other site
1185652012827	salt bridge; other site
1185652012828	sequence-specific DNA binding site [nucleotide binding]; other site
1185652012829	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1185652012830	Catalytic site [active]
1185652012831	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1185652012832	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1185652012833	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1185652012834	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
1185652012835	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
1185652012836	Stf0 sulphotransferase; Region: Sulphotransf; cl01835
1185652012837	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015
1185652012838	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
1185652012839	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1185652012840	active site
1185652012841	DNA binding site [nucleotide binding]
1185652012842	Int/Topo IB signature motif; other site
1185652012843	AAA domain; Region: AAA_25; pfam13481
1185652012844	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1185652012845	Walker A motif; other site
1185652012846	ATP binding site [chemical binding]; other site
1185652012847	Walker B motif; other site
1185652012848	Domain of unknown function (DUF4326); Region: DUF4326; pfam14216
1185652012849	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
1185652012850	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
1185652012851	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1185652012852	Helix-turn-helix domain; Region: HTH_31; pfam13560
1185652012853	non-specific DNA binding site [nucleotide binding]; other site
1185652012854	sequence-specific DNA binding site [nucleotide binding]; other site
1185652012855	salt bridge; other site
1185652012856	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652012857	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1185652012858	putative substrate translocation pore; other site
1185652012859	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1185652012860	nudix motif; other site
1185652012861	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1185652012862	putative metal binding site [ion binding]; other site
1185652012863	TIGR02594 family protein; Region: TIGR02594
1185652012864	glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417
1185652012865	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1185652012866	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1185652012867	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
1185652012868	Predicted integral membrane protein [Function unknown]; Region: COG5616
1185652012869	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652012870	TPR motif; other site
1185652012871	binding surface
1185652012872	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1185652012873	TPR motif; other site
1185652012874	binding surface
1185652012875	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652012876	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
1185652012877	DNA binding residues [nucleotide binding]
1185652012878	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
1185652012879	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1185652012880	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
1185652012881	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
1185652012882	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1185652012883	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
1185652012884	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
1185652012885	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652012886	cyclase homology domain; Region: CHD; cd07302
1185652012887	nucleotidyl binding site; other site
1185652012888	metal binding site [ion binding]; metal-binding site
1185652012889	dimer interface [polypeptide binding]; other site
1185652012890	Predicted integral membrane protein [Function unknown]; Region: COG5616
1185652012891	TPR repeat; Region: TPR_11; pfam13414
1185652012892	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652012893	binding surface
1185652012894	TPR motif; other site
1185652012895	cell division protein FtsZ; Provisional; Region: PRK13018
1185652012896	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1185652012897	nucleotide binding site [chemical binding]; other site
1185652012898	SulA interaction site; other site
1185652012899	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1185652012900	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652012901	active site
1185652012902	motif I; other site
1185652012903	motif II; other site
1185652012904	AAA ATPase domain; Region: AAA_16; pfam13191
1185652012905	Walker A motif; other site
1185652012906	ATP binding site [chemical binding]; other site
1185652012907	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1185652012908	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
1185652012909	putative C-terminal domain interface [polypeptide binding]; other site
1185652012910	putative GSH binding site (G-site) [chemical binding]; other site
1185652012911	putative dimer interface [polypeptide binding]; other site
1185652012912	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1185652012913	N-terminal domain interface [polypeptide binding]; other site
1185652012914	dimer interface [polypeptide binding]; other site
1185652012915	substrate binding pocket (H-site) [chemical binding]; other site
1185652012916	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1185652012917	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652012918	dimer interface [polypeptide binding]; other site
1185652012919	conserved gate region; other site
1185652012920	ABC-ATPase subunit interface; other site
1185652012921	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652012922	dimer interface [polypeptide binding]; other site
1185652012923	conserved gate region; other site
1185652012924	ABC-ATPase subunit interface; other site
1185652012925	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1185652012926	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1185652012927	Walker A/P-loop; other site
1185652012928	ATP binding site [chemical binding]; other site
1185652012929	Q-loop/lid; other site
1185652012930	ABC transporter signature motif; other site
1185652012931	Walker B; other site
1185652012932	D-loop; other site
1185652012933	H-loop/switch region; other site
1185652012934	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1185652012935	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1185652012936	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1185652012937	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1185652012938	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198
1185652012939	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1185652012940	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652012941	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1185652012942	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652012943	S-adenosylmethionine binding site [chemical binding]; other site
1185652012944	short chain dehydrogenase; Provisional; Region: PRK08303
1185652012945	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652012946	NAD(P) binding site [chemical binding]; other site
1185652012947	active site
1185652012948	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1185652012949	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1185652012950	C-terminal domain interface [polypeptide binding]; other site
1185652012951	GSH binding site (G-site) [chemical binding]; other site
1185652012952	dimer interface [polypeptide binding]; other site
1185652012953	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
1185652012954	N-terminal domain interface [polypeptide binding]; other site
1185652012955	dimer interface [polypeptide binding]; other site
1185652012956	substrate binding pocket (H-site) [chemical binding]; other site
1185652012957	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1185652012958	active site
1185652012959	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1185652012960	catalytic tetrad [active]
1185652012961	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1185652012962	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1185652012963	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652012964	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652012965	homodimer interface [polypeptide binding]; other site
1185652012966	catalytic residue [active]
1185652012967	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652012968	cyclase homology domain; Region: CHD; cd07302
1185652012969	nucleotidyl binding site; other site
1185652012970	metal binding site [ion binding]; metal-binding site
1185652012971	dimer interface [polypeptide binding]; other site
1185652012972	2TM domain; Region: 2TM; pfam13239
1185652012973	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1185652012974	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652012975	S-adenosylmethionine binding site [chemical binding]; other site
1185652012976	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1185652012977	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1185652012978	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1185652012979	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1185652012980	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652012981	macrolide transporter subunit MacA; Provisional; Region: PRK11578
1185652012982	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652012983	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
1185652012984	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1185652012985	Walker A/P-loop; other site
1185652012986	ATP binding site [chemical binding]; other site
1185652012987	Q-loop/lid; other site
1185652012988	ABC transporter signature motif; other site
1185652012989	Walker B; other site
1185652012990	D-loop; other site
1185652012991	H-loop/switch region; other site
1185652012992	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1185652012993	FtsX-like permease family; Region: FtsX; pfam02687
1185652012994	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
1185652012995	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
1185652012996	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
1185652012997	Catalytic site; other site
1185652012998	Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155
1185652012999	Phosphotransferase enzyme family; Region: APH; pfam01636
1185652013000	putative active site [active]
1185652013001	putative substrate binding site [chemical binding]; other site
1185652013002	ATP binding site [chemical binding]; other site
1185652013003	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1185652013004	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652013005	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652013006	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652013007	putative DNA binding site [nucleotide binding]; other site
1185652013008	putative Zn2+ binding site [ion binding]; other site
1185652013009	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652013010	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
1185652013011	aspartate racemase; Region: asp_race; TIGR00035
1185652013012	Predicted transcriptional regulators [Transcription]; Region: COG1733
1185652013013	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1185652013014	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1185652013015	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1185652013016	NADP binding site [chemical binding]; other site
1185652013017	Predicted membrane protein [Function unknown]; Region: COG2259
1185652013018	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
1185652013019	hypothetical protein; Provisional; Region: PRK05409
1185652013020	Predicted integral membrane protein [Function unknown]; Region: COG5572
1185652013021	RNA polymerase sigma factor; Provisional; Region: PRK12512
1185652013022	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1185652013023	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1185652013024	DNA binding residues [nucleotide binding]
1185652013025	Protein of unknown function (DUF1109); Region: DUF1109; cl02071
1185652013026	Protein of unknown function (DUF983); Region: DUF983; cl02211
1185652013027	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
1185652013028	active site
1185652013029	hydrophilic channel; other site
1185652013030	dimerization interface [polypeptide binding]; other site
1185652013031	catalytic residues [active]
1185652013032	active site lid [active]
1185652013033	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312
1185652013034	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
1185652013035	EF-hand domain pair; Region: EF_hand_5; pfam13499
1185652013036	Ca2+ binding site [ion binding]; other site
1185652013037	Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598
1185652013038	Zn binding site [ion binding]; other site
1185652013039	Uncharacterized conserved protein [Function unknown]; Region: COG3482
1185652013040	YcaO-like family; Region: YcaO; pfam02624
1185652013041	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
1185652013042	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
1185652013043	cyclase homology domain; Region: CHD; cd07302
1185652013044	nucleotidyl binding site; other site
1185652013045	metal binding site [ion binding]; metal-binding site
1185652013046	dimer interface [polypeptide binding]; other site
1185652013047	Predicted ATPase [General function prediction only]; Region: COG3899
1185652013048	AAA ATPase domain; Region: AAA_16; pfam13191
1185652013049	Predicted ATPase [General function prediction only]; Region: COG3903
1185652013050	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1185652013051	ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507
1185652013052	AAA domain; Region: AAA_30; pfam13604
1185652013053	Family description; Region: UvrD_C_2; pfam13538
1185652013054	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
1185652013055	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1185652013056	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1185652013057	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315
1185652013058	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
1185652013059	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
1185652013060	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1185652013061	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1185652013062	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1185652013063	DNA binding residues [nucleotide binding]
1185652013064	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1185652013065	nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889
1185652013066	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
1185652013067	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
1185652013068	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
1185652013069	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
1185652013070	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1185652013071	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1185652013072	DNA-binding site [nucleotide binding]; DNA binding site
1185652013073	RNA-binding motif; other site
1185652013074	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1185652013075	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1185652013076	active site
1185652013077	catalytic tetrad [active]
1185652013078	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1185652013079	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1185652013080	putative valine binding site [chemical binding]; other site
1185652013081	dimer interface [polypeptide binding]; other site
1185652013082	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1185652013083	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
1185652013084	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1185652013085	PYR/PP interface [polypeptide binding]; other site
1185652013086	dimer interface [polypeptide binding]; other site
1185652013087	TPP binding site [chemical binding]; other site
1185652013088	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1185652013089	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1185652013090	TPP-binding site [chemical binding]; other site
1185652013091	dimer interface [polypeptide binding]; other site
1185652013092	HerA helicase [Replication, recombination, and repair]; Region: COG0433
1185652013093	Domain of unknown function DUF87; Region: DUF87; pfam01935
1185652013094	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1185652013095	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1185652013096	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652013097	motif II; other site
1185652013098	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1185652013099	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1185652013100	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1185652013101	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1185652013102	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1185652013103	protein binding site [polypeptide binding]; other site
1185652013104	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1185652013105	protein binding site [polypeptide binding]; other site
1185652013106	Uncharacterized conserved protein [Function unknown]; Region: COG3603
1185652013107	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1185652013108	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
1185652013109	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1185652013110	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
1185652013111	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1185652013112	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1185652013113	folate binding site [chemical binding]; other site
1185652013114	NADP+ binding site [chemical binding]; other site
1185652013115	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1185652013116	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1185652013117	putative C-terminal domain interface [polypeptide binding]; other site
1185652013118	putative GSH binding site (G-site) [chemical binding]; other site
1185652013119	putative dimer interface [polypeptide binding]; other site
1185652013120	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1185652013121	N-terminal domain interface [polypeptide binding]; other site
1185652013122	dimer interface [polypeptide binding]; other site
1185652013123	substrate binding pocket (H-site) [chemical binding]; other site
1185652013124	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1185652013125	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1185652013126	dimerization interface [polypeptide binding]; other site
1185652013127	active site
1185652013128	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1185652013129	putative active site pocket [active]
1185652013130	putative catalytic residue [active]
1185652013131	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814
1185652013132	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
1185652013133	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
1185652013134	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
1185652013135	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1185652013136	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1185652013137	FAD binding domain; Region: FAD_binding_4; pfam01565
1185652013138	Domain of unknown function (DUF1772); Region: DUF1772; pfam08592
1185652013139	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1185652013140	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1185652013141	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652013142	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1185652013143	TM-ABC transporter signature motif; other site
1185652013144	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1185652013145	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1185652013146	TM-ABC transporter signature motif; other site
1185652013147	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1185652013148	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1185652013149	Walker A/P-loop; other site
1185652013150	ATP binding site [chemical binding]; other site
1185652013151	Q-loop/lid; other site
1185652013152	ABC transporter signature motif; other site
1185652013153	Walker B; other site
1185652013154	D-loop; other site
1185652013155	H-loop/switch region; other site
1185652013156	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1185652013157	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1185652013158	Walker A/P-loop; other site
1185652013159	ATP binding site [chemical binding]; other site
1185652013160	Q-loop/lid; other site
1185652013161	ABC transporter signature motif; other site
1185652013162	Walker B; other site
1185652013163	D-loop; other site
1185652013164	H-loop/switch region; other site
1185652013165	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1185652013166	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1185652013167	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652013168	DNA-binding site [nucleotide binding]; DNA binding site
1185652013169	FCD domain; Region: FCD; pfam07729
1185652013170	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1185652013171	Protein export membrane protein; Region: SecD_SecF; cl14618
1185652013172	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1185652013173	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1185652013174	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652013175	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1185652013176	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1185652013177	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1185652013178	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1185652013179	Part of AAA domain; Region: AAA_19; pfam13245
1185652013180	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
1185652013181	Family description; Region: UvrD_C_2; pfam13538
1185652013182	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1185652013183	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652013184	Coenzyme A binding pocket [chemical binding]; other site
1185652013185	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1185652013186	active site
1185652013187	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652013188	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652013189	metal binding site [ion binding]; metal-binding site
1185652013190	active site
1185652013191	I-site; other site
1185652013192	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
1185652013193	CreA protein; Region: CreA; pfam05981
1185652013194	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1185652013195	putative CheA interaction surface; other site
1185652013196	HAMP domain; Region: HAMP; pfam00672
1185652013197	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1185652013198	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1185652013199	dimer interface [polypeptide binding]; other site
1185652013200	putative CheW interface [polypeptide binding]; other site
1185652013201	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1185652013202	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1185652013203	Cu(I) binding site [ion binding]; other site
1185652013204	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
1185652013205	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652013206	S-adenosylmethionine binding site [chemical binding]; other site
1185652013207	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1185652013208	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1185652013209	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
1185652013210	active site
1185652013211	Predicted membrane protein [Function unknown]; Region: COG4541
1185652013212	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1185652013213	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1185652013214	oligomerization interface [polypeptide binding]; other site
1185652013215	active site
1185652013216	metal binding site [ion binding]; metal-binding site
1185652013217	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1185652013218	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1185652013219	active site
1185652013220	ATP-binding site [chemical binding]; other site
1185652013221	pantoate-binding site; other site
1185652013222	HXXH motif; other site
1185652013223	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1185652013224	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652013225	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1185652013226	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1185652013227	nucleotide binding pocket [chemical binding]; other site
1185652013228	K-X-D-G motif; other site
1185652013229	catalytic site [active]
1185652013230	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1185652013231	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1185652013232	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1185652013233	Dimer interface [polypeptide binding]; other site
1185652013234	BRCT sequence motif; other site
1185652013235	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1185652013236	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1185652013237	Walker A/P-loop; other site
1185652013238	ATP binding site [chemical binding]; other site
1185652013239	Q-loop/lid; other site
1185652013240	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1185652013241	ABC transporter signature motif; other site
1185652013242	Walker B; other site
1185652013243	D-loop; other site
1185652013244	H-loop/switch region; other site
1185652013245	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
1185652013246	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1185652013247	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1185652013248	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
1185652013249	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1185652013250	nucleotide binding site [chemical binding]; other site
1185652013251	SulA interaction site; other site
1185652013252	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
1185652013253	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1185652013254	Cell division protein FtsA; Region: FtsA; smart00842
1185652013255	Cell division protein FtsA; Region: FtsA; pfam14450
1185652013256	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1185652013257	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1185652013258	Cell division protein FtsQ; Region: FtsQ; pfam03799
1185652013259	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
1185652013260	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1185652013261	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1185652013262	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1185652013263	FAD binding domain; Region: FAD_binding_4; pfam01565
1185652013264	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1185652013265	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1185652013266	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1185652013267	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1185652013268	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1185652013269	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1185652013270	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1185652013271	active site
1185652013272	homodimer interface [polypeptide binding]; other site
1185652013273	cell division protein FtsW; Region: ftsW; TIGR02614
1185652013274	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
1185652013275	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1185652013276	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1185652013277	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1185652013278	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1185652013279	Mg++ binding site [ion binding]; other site
1185652013280	putative catalytic motif [active]
1185652013281	putative substrate binding site [chemical binding]; other site
1185652013282	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
1185652013283	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1185652013284	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1185652013285	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1185652013286	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1185652013287	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1185652013288	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1185652013289	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1185652013290	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1185652013291	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1185652013292	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1185652013293	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
1185652013294	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1185652013295	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652013296	S-adenosylmethionine binding site [chemical binding]; other site
1185652013297	cell division protein MraZ; Reviewed; Region: PRK00326
1185652013298	MraZ protein; Region: MraZ; pfam02381
1185652013299	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652013300	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1185652013301	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1185652013302	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1185652013303	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1185652013304	catalytic residue [active]
1185652013305	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1185652013306	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1185652013307	amidase catalytic site [active]
1185652013308	Zn binding residues [ion binding]; other site
1185652013309	substrate binding site [chemical binding]; other site
1185652013310	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1185652013311	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
1185652013312	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
1185652013313	putative metal binding site [ion binding]; other site
1185652013314	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1185652013315	pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555
1185652013316	6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205
1185652013317	active site
1185652013318	ADP/pyrophosphate binding site [chemical binding]; other site
1185652013319	allosteric effector site; other site
1185652013320	dimerization interface [polypeptide binding]; other site
1185652013321	fructose-1,6-bisphosphate binding site; other site
1185652013322	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1185652013323	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1185652013324	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1185652013325	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1185652013326	catalytic residue [active]
1185652013327	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1185652013328	Beta-lactamase; Region: Beta-lactamase; pfam00144
1185652013329	S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase [Lipid metabolism]; Region: BtaA; COG5379
1185652013330	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652013331	S-adenosylmethionine binding site [chemical binding]; other site
1185652013332	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
1185652013333	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
1185652013334	active site
1185652013335	lytic murein transglycosylase; Region: MltB_2; TIGR02283
1185652013336	murein hydrolase B; Provisional; Region: PRK10760; cl17906
1185652013337	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1185652013338	EamA-like transporter family; Region: EamA; pfam00892
1185652013339	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1185652013340	EamA-like transporter family; Region: EamA; pfam00892
1185652013341	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1185652013342	FAD binding site [chemical binding]; other site
1185652013343	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652013344	dimerization interface [polypeptide binding]; other site
1185652013345	putative DNA binding site [nucleotide binding]; other site
1185652013346	putative Zn2+ binding site [ion binding]; other site
1185652013347	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652013348	S-adenosylmethionine binding site [chemical binding]; other site
1185652013349	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1185652013350	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652013351	Walker A/P-loop; other site
1185652013352	ATP binding site [chemical binding]; other site
1185652013353	Q-loop/lid; other site
1185652013354	ABC transporter signature motif; other site
1185652013355	Walker B; other site
1185652013356	D-loop; other site
1185652013357	H-loop/switch region; other site
1185652013358	ABC transporter; Region: ABC_tran_2; pfam12848
1185652013359	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1185652013360	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
1185652013361	B1 nucleotide binding pocket [chemical binding]; other site
1185652013362	B2 nucleotide binding pocket [chemical binding]; other site
1185652013363	CAS motifs; other site
1185652013364	active site
1185652013365	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1185652013366	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1185652013367	thiamine pyrophosphate protein; Validated; Region: PRK08199
1185652013368	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1185652013369	PYR/PP interface [polypeptide binding]; other site
1185652013370	dimer interface [polypeptide binding]; other site
1185652013371	TPP binding site [chemical binding]; other site
1185652013372	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1185652013373	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1185652013374	TPP-binding site [chemical binding]; other site
1185652013375	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453
1185652013376	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
1185652013377	active site
1185652013378	catalytic residues [active]
1185652013379	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1185652013380	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1185652013381	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1185652013382	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1185652013383	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652013384	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1185652013385	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1185652013386	Magnesium ion binding site [ion binding]; other site
1185652013387	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1185652013388	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
1185652013389	putative active site [active]
1185652013390	metal binding site [ion binding]; metal-binding site
1185652013391	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1185652013392	Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102
1185652013393	NAD(P) binding site [chemical binding]; other site
1185652013394	catalytic residues [active]
1185652013395	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1185652013396	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1185652013397	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1185652013398	amino acid permease (GABA permease); Region: 2A0304; TIGR00907
1185652013399	Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931
1185652013400	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1185652013401	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1185652013402	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1185652013403	putative active site [active]
1185652013404	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1185652013405	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1185652013406	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1185652013407	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652013408	dimer interface [polypeptide binding]; other site
1185652013409	conserved gate region; other site
1185652013410	putative PBP binding loops; other site
1185652013411	ABC-ATPase subunit interface; other site
1185652013412	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1185652013413	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652013414	dimer interface [polypeptide binding]; other site
1185652013415	conserved gate region; other site
1185652013416	putative PBP binding loops; other site
1185652013417	ABC-ATPase subunit interface; other site
1185652013418	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1185652013419	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652013420	Walker A/P-loop; other site
1185652013421	ATP binding site [chemical binding]; other site
1185652013422	Q-loop/lid; other site
1185652013423	ABC transporter signature motif; other site
1185652013424	Walker B; other site
1185652013425	D-loop; other site
1185652013426	H-loop/switch region; other site
1185652013427	TOBE domain; Region: TOBE_2; pfam08402
1185652013428	riboflavin synthase subunit beta; Provisional; Region: PRK12419
1185652013429	active site
1185652013430	homopentamer interface [polypeptide binding]; other site
1185652013431	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1185652013432	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1185652013433	conserved cys residue [active]
1185652013434	Uncharacterized conserved protein [Function unknown]; Region: COG3246
1185652013435	bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531
1185652013436	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1185652013437	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1185652013438	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1185652013439	active site
1185652013440	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1185652013441	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1185652013442	active site
1185652013443	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
1185652013444	CoA binding domain; Region: CoA_binding_2; pfam13380
1185652013445	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
1185652013446	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
1185652013447	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
1185652013448	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1185652013449	substrate binding site [chemical binding]; other site
1185652013450	oxyanion hole (OAH) forming residues; other site
1185652013451	trimer interface [polypeptide binding]; other site
1185652013452	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1185652013453	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
1185652013454	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1185652013455	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652013456	dimer interface [polypeptide binding]; other site
1185652013457	conserved gate region; other site
1185652013458	ABC-ATPase subunit interface; other site
1185652013459	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1185652013460	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652013461	dimer interface [polypeptide binding]; other site
1185652013462	conserved gate region; other site
1185652013463	ABC-ATPase subunit interface; other site
1185652013464	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1185652013465	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652013466	Walker A/P-loop; other site
1185652013467	ATP binding site [chemical binding]; other site
1185652013468	Q-loop/lid; other site
1185652013469	ABC transporter signature motif; other site
1185652013470	Walker B; other site
1185652013471	D-loop; other site
1185652013472	H-loop/switch region; other site
1185652013473	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652013474	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652013475	Walker A/P-loop; other site
1185652013476	ATP binding site [chemical binding]; other site
1185652013477	Q-loop/lid; other site
1185652013478	ABC transporter signature motif; other site
1185652013479	Walker B; other site
1185652013480	D-loop; other site
1185652013481	H-loop/switch region; other site
1185652013482	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652013483	Predicted acyl esterases [General function prediction only]; Region: COG2936
1185652013484	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1185652013485	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
1185652013486	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602
1185652013487	ACT domain; Region: ACT_3; pfam10000
1185652013488	Family description; Region: ACT_7; pfam13840
1185652013489	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652013490	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652013491	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
1185652013492	putative substrate binding pocket [chemical binding]; other site
1185652013493	dimerization interface [polypeptide binding]; other site
1185652013494	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1185652013495	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1185652013496	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1185652013497	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652013498	Walker A/P-loop; other site
1185652013499	ATP binding site [chemical binding]; other site
1185652013500	Q-loop/lid; other site
1185652013501	ABC transporter signature motif; other site
1185652013502	Walker B; other site
1185652013503	D-loop; other site
1185652013504	H-loop/switch region; other site
1185652013505	TOBE domain; Region: TOBE_2; pfam08402
1185652013506	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652013507	putative PBP binding loops; other site
1185652013508	dimer interface [polypeptide binding]; other site
1185652013509	ABC-ATPase subunit interface; other site
1185652013510	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1185652013511	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652013512	dimer interface [polypeptide binding]; other site
1185652013513	conserved gate region; other site
1185652013514	putative PBP binding loops; other site
1185652013515	ABC-ATPase subunit interface; other site
1185652013516	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
1185652013517	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
1185652013518	tetrameric interface [polypeptide binding]; other site
1185652013519	NAD binding site [chemical binding]; other site
1185652013520	catalytic residues [active]
1185652013521	substrate binding site [chemical binding]; other site
1185652013522	Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114
1185652013523	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1185652013524	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
1185652013525	ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048
1185652013526	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1185652013527	intersubunit interface [polypeptide binding]; other site
1185652013528	Isochorismatase family; Region: Isochorismatase; pfam00857
1185652013529	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1185652013530	catalytic triad [active]
1185652013531	conserved cis-peptide bond; other site
1185652013532	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652013533	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1185652013534	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652013535	Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598
1185652013536	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652013537	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1185652013538	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
1185652013539	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
1185652013540	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1185652013541	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652013542	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1185652013543	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
1185652013544	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1185652013545	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652013546	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652013547	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1185652013548	dimerization interface [polypeptide binding]; other site
1185652013549	Predicted membrane protein [Function unknown]; Region: COG4425
1185652013550	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
1185652013551	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1185652013552	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652013553	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652013554	putative DNA binding site [nucleotide binding]; other site
1185652013555	putative Zn2+ binding site [ion binding]; other site
1185652013556	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652013557	methionine gamma-lyase; Validated; Region: PRK07049
1185652013558	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1185652013559	homodimer interface [polypeptide binding]; other site
1185652013560	substrate-cofactor binding pocket; other site
1185652013561	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652013562	catalytic residue [active]
1185652013563	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1185652013564	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652013565	Predicted integral membrane protein [Function unknown]; Region: COG5500
1185652013566	cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459
1185652013567	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
1185652013568	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1185652013569	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
1185652013570	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
1185652013571	Putative glucoamylase; Region: Glycoamylase; pfam10091
1185652013572	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1185652013573	metal ion-dependent adhesion site (MIDAS); other site
1185652013574	Uncharacterized conserved protein [Function unknown]; Region: COG1944
1185652013575	YcaO-like family; Region: YcaO; pfam02624
1185652013576	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
1185652013577	Predicted integral membrane protein [Function unknown]; Region: COG5616
1185652013578	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652013579	TPR motif; other site
1185652013580	binding surface
1185652013581	TPR repeat; Region: TPR_11; pfam13414
1185652013582	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652013583	binding surface
1185652013584	TPR motif; other site
1185652013585	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1185652013586	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652013587	non-specific DNA binding site [nucleotide binding]; other site
1185652013588	salt bridge; other site
1185652013589	sequence-specific DNA binding site [nucleotide binding]; other site
1185652013590	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
1185652013591	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1185652013592	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1185652013593	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
1185652013594	4Fe-4S binding domain; Region: Fer4; pfam00037
1185652013595	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1185652013596	FOG: CBS domain [General function prediction only]; Region: COG0517
1185652013597	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1185652013598	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1185652013599	catalytic loop [active]
1185652013600	iron binding site [ion binding]; other site
1185652013601	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1185652013602	4Fe-4S binding domain; Region: Fer4; pfam00037
1185652013603	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
1185652013604	[4Fe-4S] binding site [ion binding]; other site
1185652013605	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1185652013606	molybdopterin cofactor binding site; other site
1185652013607	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
1185652013608	SLBB domain; Region: SLBB; pfam10531
1185652013609	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
1185652013610	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
1185652013611	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1185652013612	putative dimer interface [polypeptide binding]; other site
1185652013613	[2Fe-2S] cluster binding site [ion binding]; other site
1185652013614	NADH dehydrogenase subunit D; Validated; Region: PRK06075
1185652013615	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
1185652013616	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
1185652013617	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
1185652013618	NADH dehydrogenase subunit B; Validated; Region: PRK06411
1185652013619	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
1185652013620	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1185652013621	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1185652013622	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
1185652013623	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1185652013624	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668
1185652013625	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1185652013626	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
1185652013627	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1185652013628	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
1185652013629	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
1185652013630	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1185652013631	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1185652013632	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1185652013633	conjugal transfer protein TrbA; Provisional; Region: PRK13890
1185652013634	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
1185652013635	Domain of unknown function (DUF4326); Region: DUF4326; pfam14216
1185652013636	AAA domain; Region: AAA_25; pfam13481
1185652013637	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1185652013638	Walker A motif; other site
1185652013639	ATP binding site [chemical binding]; other site
1185652013640	Walker B motif; other site
1185652013641	Helix-turn-helix domain; Region: HTH_17; cl17695
1185652013642	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1185652013643	active site
1185652013644	Int/Topo IB signature motif; other site
1185652013645	DNA binding site [nucleotide binding]
1185652013646	conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096
1185652013647	Uncharacterized conserved protein [Function unknown]; Region: COG0432
1185652013648	Uncharacterized conserved protein [Function unknown]; Region: COG5507
1185652013649	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1185652013650	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1185652013651	catalytic residue [active]
1185652013652	Uncharacterized conserved protein [Function unknown]; Region: COG4274
1185652013653	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1185652013654	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1185652013655	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1185652013656	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
1185652013657	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1185652013658	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1185652013659	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1185652013660	DNA binding residues [nucleotide binding]
1185652013661	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
1185652013662	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1185652013663	NAD(P) binding site [chemical binding]; other site
1185652013664	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1185652013665	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1185652013666	substrate-cofactor binding pocket; other site
1185652013667	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652013668	catalytic residue [active]
1185652013669	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1185652013670	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1185652013671	ATP binding site [chemical binding]; other site
1185652013672	putative Mg++ binding site [ion binding]; other site
1185652013673	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1185652013674	nucleotide binding region [chemical binding]; other site
1185652013675	ATP-binding site [chemical binding]; other site
1185652013676	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1185652013677	HRDC domain; Region: HRDC; pfam00570
1185652013678	DNA primase; Validated; Region: dnaG; PRK05667
1185652013679	CHC2 zinc finger; Region: zf-CHC2; cl17510
1185652013680	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1185652013681	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1185652013682	active site
1185652013683	metal binding site [ion binding]; metal-binding site
1185652013684	interdomain interaction site; other site
1185652013685	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1185652013686	Uncharacterized conserved protein [Function unknown]; Region: COG1610
1185652013687	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1185652013688	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1185652013689	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1185652013690	catalytic site [active]
1185652013691	subunit interface [polypeptide binding]; other site
1185652013692	LysR family transcriptional regulator; Provisional; Region: PRK14997
1185652013693	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652013694	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1185652013695	putative effector binding pocket; other site
1185652013696	dimerization interface [polypeptide binding]; other site
1185652013697	short chain dehydrogenase; Provisional; Region: PRK06500
1185652013698	classical (c) SDRs; Region: SDR_c; cd05233
1185652013699	NAD(P) binding site [chemical binding]; other site
1185652013700	active site
1185652013701	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1185652013702	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1185652013703	aspartate aminotransferase; Provisional; Region: PRK05764
1185652013704	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652013705	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652013706	homodimer interface [polypeptide binding]; other site
1185652013707	catalytic residue [active]
1185652013708	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
1185652013709	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1185652013710	EamA-like transporter family; Region: EamA; pfam00892
1185652013711	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1185652013712	DNA-binding site [nucleotide binding]; DNA binding site
1185652013713	RNA-binding motif; other site
1185652013714	BA14K-like protein; Region: BA14K; pfam07886
1185652013715	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1185652013716	Bacterial SH3 domain; Region: SH3_3; pfam08239
1185652013717	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
1185652013718	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1185652013719	MarR family; Region: MarR_2; pfam12802
1185652013720	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1185652013721	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652013722	active site
1185652013723	phosphorylation site [posttranslational modification]
1185652013724	intermolecular recognition site; other site
1185652013725	dimerization interface [polypeptide binding]; other site
1185652013726	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652013727	DNA binding site [nucleotide binding]
1185652013728	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652013729	HAMP domain; Region: HAMP; pfam00672
1185652013730	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1185652013731	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652013732	ATP binding site [chemical binding]; other site
1185652013733	Mg2+ binding site [ion binding]; other site
1185652013734	G-X-G motif; other site
1185652013735	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
1185652013736	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
1185652013737	dimer interface [polypeptide binding]; other site
1185652013738	putative tRNA-binding site [nucleotide binding]; other site
1185652013739	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
1185652013740	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1185652013741	Uncharacterized conserved protein [Function unknown]; Region: COG5465
1185652013742	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
1185652013743	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1185652013744	Uncharacterized conserved protein [Function unknown]; Region: COG1565
1185652013745	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1185652013746	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1185652013747	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1185652013748	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1185652013749	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1185652013750	active site
1185652013751	cell division protein ZipA; Provisional; Region: PRK03427
1185652013752	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1185652013753	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1185652013754	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1185652013755	active site
1185652013756	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1185652013757	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1185652013758	tetramer interface [polypeptide binding]; other site
1185652013759	active site
1185652013760	Mg2+/Mn2+ binding site [ion binding]; other site
1185652013761	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564
1185652013762	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
1185652013763	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1185652013764	NAD(P) binding site [chemical binding]; other site
1185652013765	catalytic residues [active]
1185652013766	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1185652013767	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1185652013768	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
1185652013769	benzoate transporter; Region: benE; TIGR00843
1185652013770	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1185652013771	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1185652013772	5S rRNA interface [nucleotide binding]; other site
1185652013773	CTC domain interface [polypeptide binding]; other site
1185652013774	L16 interface [polypeptide binding]; other site
1185652013775	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1185652013776	dimerization interface [polypeptide binding]; other site
1185652013777	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652013778	PAS domain; Region: PAS_9; pfam13426
1185652013779	putative active site [active]
1185652013780	heme pocket [chemical binding]; other site
1185652013781	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652013782	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652013783	metal binding site [ion binding]; metal-binding site
1185652013784	active site
1185652013785	I-site; other site
1185652013786	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1185652013787	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1185652013788	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1185652013789	substrate binding pocket [chemical binding]; other site
1185652013790	membrane-bound complex binding site; other site
1185652013791	hinge residues; other site
1185652013792	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1185652013793	putative active site [active]
1185652013794	catalytic residue [active]
1185652013795	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
1185652013796	GTP-binding protein YchF; Reviewed; Region: PRK09601
1185652013797	YchF GTPase; Region: YchF; cd01900
1185652013798	G1 box; other site
1185652013799	GTP/Mg2+ binding site [chemical binding]; other site
1185652013800	Switch I region; other site
1185652013801	G2 box; other site
1185652013802	Switch II region; other site
1185652013803	G3 box; other site
1185652013804	G4 box; other site
1185652013805	G5 box; other site
1185652013806	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1185652013807	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
1185652013808	putative active site [active]
1185652013809	putative catalytic site [active]
1185652013810	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
1185652013811	putative active site [active]
1185652013812	putative catalytic site [active]
1185652013813	Domain of unknown function (DUF1873); Region: DUF1873; pfam08969
1185652013814	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1185652013815	active site
1185652013816	Predicted small metal-binding protein [Function unknown]; Region: COG5466
1185652013817	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
1185652013818	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1185652013819	active site
1185652013820	NTP binding site [chemical binding]; other site
1185652013821	metal binding triad [ion binding]; metal-binding site
1185652013822	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1185652013823	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1185652013824	putative active site [active]
1185652013825	putative CoA binding site [chemical binding]; other site
1185652013826	nudix motif; other site
1185652013827	metal binding site [ion binding]; metal-binding site
1185652013828	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
1185652013829	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
1185652013830	MoxR-like ATPases [General function prediction only]; Region: COG0714
1185652013831	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652013832	Walker A motif; other site
1185652013833	ATP binding site [chemical binding]; other site
1185652013834	Walker B motif; other site
1185652013835	arginine finger; other site
1185652013836	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1185652013837	Protein of unknown function DUF58; Region: DUF58; pfam01882
1185652013838	CARDB; Region: CARDB; pfam07705
1185652013839	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
1185652013840	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1185652013841	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652013842	Coenzyme A binding pocket [chemical binding]; other site
1185652013843	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
1185652013844	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
1185652013845	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
1185652013846	putative dimer interface [polypeptide binding]; other site
1185652013847	N-terminal domain interface [polypeptide binding]; other site
1185652013848	putative substrate binding pocket (H-site) [chemical binding]; other site
1185652013849	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
1185652013850	nudix motif; other site
1185652013851	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1185652013852	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
1185652013853	putative active site [active]
1185652013854	putative metal binding site [ion binding]; other site
1185652013855	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1185652013856	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652013857	binding surface
1185652013858	TPR motif; other site
1185652013859	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1185652013860	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1185652013861	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1185652013862	DNA binding residues [nucleotide binding]
1185652013863	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1185652013864	2-isopropylmalate synthase; Validated; Region: PRK03739
1185652013865	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1185652013866	active site
1185652013867	catalytic residues [active]
1185652013868	metal binding site [ion binding]; metal-binding site
1185652013869	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1185652013870	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
1185652013871	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1185652013872	oligomer interface [polypeptide binding]; other site
1185652013873	active site residues [active]
1185652013874	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
1185652013875	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
1185652013876	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1185652013877	Cation efflux family; Region: Cation_efflux; cl00316
1185652013878	anthranilate synthase; Provisional; Region: PRK13566
1185652013879	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1185652013880	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1185652013881	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1185652013882	glutamine binding [chemical binding]; other site
1185652013883	catalytic triad [active]
1185652013884	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
1185652013885	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1185652013886	N-terminal plug; other site
1185652013887	ligand-binding site [chemical binding]; other site
1185652013888	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
1185652013889	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
1185652013890	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; cl17557
1185652013891	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
1185652013892	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1185652013893	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1185652013894	Potassium binding sites [ion binding]; other site
1185652013895	Cesium cation binding sites [ion binding]; other site
1185652013896	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345
1185652013897	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
1185652013898	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1185652013899	thymidine kinase; Provisional; Region: PRK04296
1185652013900	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1185652013901	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
1185652013902	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652013903	dimer interface [polypeptide binding]; other site
1185652013904	conserved gate region; other site
1185652013905	putative PBP binding loops; other site
1185652013906	ABC-ATPase subunit interface; other site
1185652013907	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
1185652013908	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652013909	Walker A/P-loop; other site
1185652013910	ATP binding site [chemical binding]; other site
1185652013911	Q-loop/lid; other site
1185652013912	ABC transporter signature motif; other site
1185652013913	Walker B; other site
1185652013914	D-loop; other site
1185652013915	H-loop/switch region; other site
1185652013916	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1185652013917	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
1185652013918	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
1185652013919	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652013920	dimerization interface [polypeptide binding]; other site
1185652013921	putative DNA binding site [nucleotide binding]; other site
1185652013922	putative Zn2+ binding site [ion binding]; other site
1185652013923	omega amino acid--pyruvate transaminase; Provisional; Region: PRK13360
1185652013924	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1185652013925	inhibitor-cofactor binding pocket; inhibition site
1185652013926	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652013927	catalytic residue [active]
1185652013928	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
1185652013929	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1185652013930	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
1185652013931	active site
1185652013932	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
1185652013933	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
1185652013934	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1185652013935	active site
1185652013936	catalytic site [active]
1185652013937	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1185652013938	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1185652013939	substrate binding site [chemical binding]; other site
1185652013940	ATP binding site [chemical binding]; other site
1185652013941	GTP-binding protein Der; Reviewed; Region: PRK00093
1185652013942	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1185652013943	G1 box; other site
1185652013944	GTP/Mg2+ binding site [chemical binding]; other site
1185652013945	Switch I region; other site
1185652013946	G2 box; other site
1185652013947	Switch II region; other site
1185652013948	G3 box; other site
1185652013949	G4 box; other site
1185652013950	G5 box; other site
1185652013951	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1185652013952	G1 box; other site
1185652013953	GTP/Mg2+ binding site [chemical binding]; other site
1185652013954	Switch I region; other site
1185652013955	G2 box; other site
1185652013956	G3 box; other site
1185652013957	Switch II region; other site
1185652013958	G4 box; other site
1185652013959	G5 box; other site
1185652013960	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
1185652013961	NnrU protein; Region: NnrU; cl17713
1185652013962	Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976
1185652013963	NodB motif; other site
1185652013964	putative active site [active]
1185652013965	putative catalytic site [active]
1185652013966	microcin B17 transporter; Reviewed; Region: PRK11098
1185652013967	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652013968	putative substrate translocation pore; other site
1185652013969	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1185652013970	active site
1185652013971	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1185652013972	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1185652013973	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1185652013974	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
1185652013975	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1185652013976	N- and C-terminal domain interface [polypeptide binding]; other site
1185652013977	active site
1185652013978	MgATP binding site [chemical binding]; other site
1185652013979	catalytic site [active]
1185652013980	metal binding site [ion binding]; metal-binding site
1185652013981	glycerol binding site [chemical binding]; other site
1185652013982	homotetramer interface [polypeptide binding]; other site
1185652013983	homodimer interface [polypeptide binding]; other site
1185652013984	FBP binding site [chemical binding]; other site
1185652013985	protein IIAGlc interface [polypeptide binding]; other site
1185652013986	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
1185652013987	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
1185652013988	NAD binding site [chemical binding]; other site
1185652013989	homotetramer interface [polypeptide binding]; other site
1185652013990	homodimer interface [polypeptide binding]; other site
1185652013991	substrate binding site [chemical binding]; other site
1185652013992	active site
1185652013993	Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630
1185652013994	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1185652013995	catalytic loop [active]
1185652013996	iron binding site [ion binding]; other site
1185652013997	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1185652013998	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
1185652013999	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
1185652014000	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1185652014001	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1185652014002	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1185652014003	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652014004	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1185652014005	dimerization interface [polypeptide binding]; other site
1185652014006	substrate binding pocket [chemical binding]; other site
1185652014007	Predicted membrane protein [Function unknown]; Region: COG3748
1185652014008	Protein of unknown function (DUF989); Region: DUF989; pfam06181
1185652014009	Cytochrome c; Region: Cytochrom_C; pfam00034
1185652014010	guanine deaminase; Provisional; Region: PRK09228
1185652014011	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
1185652014012	active site
1185652014013	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1185652014014	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
1185652014015	phosphate binding site [ion binding]; other site
1185652014016	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1185652014017	active site
1185652014018	homotetramer interface [polypeptide binding]; other site
1185652014019	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
1185652014020	ureidoglycolate hydrolase; Provisional; Region: PRK03606
1185652014021	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
1185652014022	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
1185652014023	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
1185652014024	active site
1185652014025	catalytic site [active]
1185652014026	tetramer interface [polypeptide binding]; other site
1185652014027	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
1185652014028	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652014029	Uncharacterized conserved protein [Function unknown]; Region: COG4121
1185652014030	Protein required for attachment to host cells; Region: Host_attach; cl02398
1185652014031	helicase 45; Provisional; Region: PTZ00424
1185652014032	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1185652014033	ATP binding site [chemical binding]; other site
1185652014034	Mg++ binding site [ion binding]; other site
1185652014035	motif III; other site
1185652014036	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1185652014037	nucleotide binding region [chemical binding]; other site
1185652014038	ATP-binding site [chemical binding]; other site
1185652014039	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1185652014040	Isochorismatase family; Region: Isochorismatase; pfam00857
1185652014041	catalytic triad [active]
1185652014042	conserved cis-peptide bond; other site
1185652014043	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1185652014044	EamA-like transporter family; Region: EamA; pfam00892
1185652014045	EamA-like transporter family; Region: EamA; pfam00892
1185652014046	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1185652014047	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1185652014048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1185652014049	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1185652014050	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1185652014051	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1185652014052	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1185652014053	dihydroxy-acid dehydratase; Validated; Region: PRK06131
1185652014054	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
1185652014055	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1185652014056	NAD(P) binding site [chemical binding]; other site
1185652014057	catalytic residues [active]
1185652014058	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
1185652014059	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1185652014060	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652014061	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652014062	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652014063	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652014064	TM-ABC transporter signature motif; other site
1185652014065	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1185652014066	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652014067	Walker A/P-loop; other site
1185652014068	ATP binding site [chemical binding]; other site
1185652014069	Q-loop/lid; other site
1185652014070	ABC transporter signature motif; other site
1185652014071	Walker B; other site
1185652014072	D-loop; other site
1185652014073	H-loop/switch region; other site
1185652014074	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652014075	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
1185652014076	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1185652014077	putative ligand binding site [chemical binding]; other site
1185652014078	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1185652014079	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652014080	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652014081	dimerization interface [polypeptide binding]; other site
1185652014082	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652014083	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652014084	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1185652014085	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1185652014086	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1185652014087	PAS domain S-box; Region: sensory_box; TIGR00229
1185652014088	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1185652014089	putative active site [active]
1185652014090	heme pocket [chemical binding]; other site
1185652014091	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652014092	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652014093	metal binding site [ion binding]; metal-binding site
1185652014094	active site
1185652014095	I-site; other site
1185652014096	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1185652014097	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1185652014098	non-specific DNA interactions [nucleotide binding]; other site
1185652014099	DNA binding site [nucleotide binding]
1185652014100	sequence specific DNA binding site [nucleotide binding]; other site
1185652014101	putative cAMP binding site [chemical binding]; other site
1185652014102	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1185652014103	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
1185652014104	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1185652014105	putative ligand binding site [chemical binding]; other site
1185652014106	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652014107	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652014108	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652014109	TM-ABC transporter signature motif; other site
1185652014110	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1185652014111	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652014112	Walker A/P-loop; other site
1185652014113	ATP binding site [chemical binding]; other site
1185652014114	Q-loop/lid; other site
1185652014115	ABC transporter signature motif; other site
1185652014116	Walker B; other site
1185652014117	D-loop; other site
1185652014118	H-loop/switch region; other site
1185652014119	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
1185652014120	His-Xaa-Ser system protein, TIGR03982 family; Region: TIGR03982
1185652014121	His-Xaa-Ser repeat protein HxsA; Region: His_Ser_Rich; TIGR03979
1185652014122	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1185652014123	His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977
1185652014124	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1185652014125	FeS/SAM binding site; other site
1185652014126	His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978
1185652014127	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1185652014128	FeS/SAM binding site; other site
1185652014129	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1185652014130	Staphylococcal nuclease homologues; Region: SNc; smart00318
1185652014131	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
1185652014132	Catalytic site; other site
1185652014133	1-deoxy-D-xylulose-5-phosphate synthase; Region: PLN02234
1185652014134	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652014135	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1185652014136	Walker A motif; other site
1185652014137	ATP binding site [chemical binding]; other site
1185652014138	Walker B motif; other site
1185652014139	arginine finger; other site
1185652014140	Peptidase family M41; Region: Peptidase_M41; pfam01434
1185652014141	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
1185652014142	Part of AAA domain; Region: AAA_19; pfam13245
1185652014143	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1185652014144	AAA domain; Region: AAA_12; pfam13087
1185652014145	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1185652014146	putative active site [active]
1185652014147	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
1185652014148	Predicted periplasmic protein [Function unknown]; Region: COG3904
1185652014149	Predicted periplasmic protein [Function unknown]; Region: COG3904
1185652014150	Predicted periplasmic protein [Function unknown]; Region: COG3904
1185652014151	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
1185652014152	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446
1185652014153	GIY-YIG motif/motif A; other site
1185652014154	putative active site [active]
1185652014155	putative metal binding site [ion binding]; other site
1185652014156	Competence protein CoiA-like family; Region: CoiA; cl11541
1185652014157	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1185652014158	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
1185652014159	putative active site [active]
1185652014160	putative metal binding site [ion binding]; other site
1185652014161	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652014162	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1185652014163	Walker A motif; other site
1185652014164	ATP binding site [chemical binding]; other site
1185652014165	Walker B motif; other site
1185652014166	arginine finger; other site
1185652014167	Peptidase family M41; Region: Peptidase_M41; pfam01434
1185652014168	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1185652014169	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1185652014170	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1185652014171	Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100
1185652014172	putative binding site; other site
1185652014173	PAN domain; Region: PAN_4; pfam14295
1185652014174	putative binding site; other site
1185652014175	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1185652014176	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1185652014177	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1185652014178	FAD binding domain; Region: FAD_binding_4; pfam01565
1185652014179	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
1185652014180	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
1185652014181	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1185652014182	homotrimer interaction site [polypeptide binding]; other site
1185652014183	putative active site [active]
1185652014184	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
1185652014185	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1185652014186	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1185652014187	catalytic residue [active]
1185652014188	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1185652014189	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652014190	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1185652014191	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1185652014192	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1185652014193	conserved cys residue [active]
1185652014194	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652014195	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1185652014196	classical (c) SDRs; Region: SDR_c; cd05233
1185652014197	NAD(P) binding site [chemical binding]; other site
1185652014198	active site
1185652014199	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1185652014200	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
1185652014201	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1185652014202	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1185652014203	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1185652014204	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1185652014205	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652014206	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652014207	dimerization interface [polypeptide binding]; other site
1185652014208	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1185652014209	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1185652014210	catalytic site [active]
1185652014211	TIR domain; Region: TIR_2; pfam13676
1185652014212	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
1185652014213	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
1185652014214	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1185652014215	Ligand Binding Site [chemical binding]; other site
1185652014216	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1185652014217	active site
1185652014218	Integrase core domain; Region: rve; pfam00665
1185652014219	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
1185652014220	AAA ATPase domain; Region: AAA_16; pfam13191
1185652014221	AAA domain; Region: AAA_22; pfam13401
1185652014222	TniQ; Region: TniQ; pfam06527
1185652014223	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1185652014224	Transposase; Region: HTH_Tnp_1; pfam01527
1185652014225	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652014226	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1185652014227	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1185652014228	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652014229	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1185652014230	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652014231	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1185652014232	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
1185652014233	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634
1185652014234	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652014235	cyclase homology domain; Region: CHD; cd07302
1185652014236	nucleotidyl binding site; other site
1185652014237	metal binding site [ion binding]; metal-binding site
1185652014238	dimer interface [polypeptide binding]; other site
1185652014239	Uncharacterized conserved protein [Function unknown]; Region: COG3189
1185652014240	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
1185652014241	Ca2+ binding site [ion binding]; other site
1185652014242	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
1185652014243	tyrosine decarboxylase; Region: PLN02880
1185652014244	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1185652014245	catalytic residue [active]
1185652014246	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1185652014247	FAD binding domain; Region: FAD_binding_4; pfam01565
1185652014248	Berberine and berberine like; Region: BBE; pfam08031
1185652014249	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1185652014250	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
1185652014251	substrate binding site; other site
1185652014252	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
1185652014253	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
1185652014254	NAD binding site [chemical binding]; other site
1185652014255	homotetramer interface [polypeptide binding]; other site
1185652014256	homodimer interface [polypeptide binding]; other site
1185652014257	substrate binding site [chemical binding]; other site
1185652014258	active site
1185652014259	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
1185652014260	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1185652014261	Methyltransferase domain; Region: Methyltransf_12; pfam08242
1185652014262	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
1185652014263	Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510
1185652014264	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1185652014265	extended (e) SDRs; Region: SDR_e; cd08946
1185652014266	NAD(P) binding site [chemical binding]; other site
1185652014267	substrate binding site [chemical binding]; other site
1185652014268	active site
1185652014269	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1185652014270	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1185652014271	trimer interface [polypeptide binding]; other site
1185652014272	active site
1185652014273	substrate binding site [chemical binding]; other site
1185652014274	CoA binding site [chemical binding]; other site
1185652014275	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1185652014276	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652014277	Walker A/P-loop; other site
1185652014278	ATP binding site [chemical binding]; other site
1185652014279	Q-loop/lid; other site
1185652014280	ABC transporter signature motif; other site
1185652014281	Walker B; other site
1185652014282	D-loop; other site
1185652014283	H-loop/switch region; other site
1185652014284	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1185652014285	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652014286	Walker A/P-loop; other site
1185652014287	ATP binding site [chemical binding]; other site
1185652014288	Q-loop/lid; other site
1185652014289	ABC transporter signature motif; other site
1185652014290	Walker B; other site
1185652014291	D-loop; other site
1185652014292	H-loop/switch region; other site
1185652014293	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652014294	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1185652014295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652014296	ABC-ATPase subunit interface; other site
1185652014297	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1185652014298	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652014299	dimer interface [polypeptide binding]; other site
1185652014300	conserved gate region; other site
1185652014301	putative PBP binding loops; other site
1185652014302	ABC-ATPase subunit interface; other site
1185652014303	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1185652014304	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
1185652014305	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1185652014306	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
1185652014307	active site
1185652014308	dimer interface [polypeptide binding]; other site
1185652014309	Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA; cl00012
1185652014310	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
1185652014311	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1185652014312	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1185652014313	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652014314	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1185652014315	apolar tunnel; other site
1185652014316	heme binding site [chemical binding]; other site
1185652014317	dimerization interface [polypeptide binding]; other site
1185652014318	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
1185652014319	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1185652014320	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
1185652014321	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1185652014322	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
1185652014323	Hemin uptake protein hemP; Region: hemP; pfam10636
1185652014324	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
1185652014325	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
1185652014326	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
1185652014327	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
1185652014328	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1185652014329	putative hemin binding site; other site
1185652014330	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1185652014331	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1185652014332	putative PBP binding regions; other site
1185652014333	ABC-ATPase subunit  interface; other site
1185652014334	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
1185652014335	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1185652014336	Walker A/P-loop; other site
1185652014337	ATP binding site [chemical binding]; other site
1185652014338	Q-loop/lid; other site
1185652014339	ABC transporter signature motif; other site
1185652014340	Walker B; other site
1185652014341	D-loop; other site
1185652014342	H-loop/switch region; other site
1185652014343	GAF domain; Region: GAF; pfam01590
1185652014344	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1185652014345	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652014346	putative active site [active]
1185652014347	PAS fold; Region: PAS_3; pfam08447
1185652014348	heme pocket [chemical binding]; other site
1185652014349	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1185652014350	HWE histidine kinase; Region: HWE_HK; pfam07536
1185652014351	RNA polymerase sigma factor; Provisional; Region: PRK12516
1185652014352	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1185652014353	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1185652014354	DNA binding residues [nucleotide binding]
1185652014355	two-component response regulator; Provisional; Region: PRK09191
1185652014356	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1185652014357	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652014358	active site
1185652014359	phosphorylation site [posttranslational modification]
1185652014360	intermolecular recognition site; other site
1185652014361	dimerization interface [polypeptide binding]; other site
1185652014362	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
1185652014363	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
1185652014364	N- and C-terminal domain interface [polypeptide binding]; other site
1185652014365	active site
1185652014366	MgATP binding site [chemical binding]; other site
1185652014367	catalytic site [active]
1185652014368	metal binding site [ion binding]; metal-binding site
1185652014369	carbohydrate binding site [chemical binding]; other site
1185652014370	putative homodimer interface [polypeptide binding]; other site
1185652014371	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1185652014372	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652014373	motif II; other site
1185652014374	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1185652014375	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1185652014376	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1185652014377	sorbitol dehydrogenase; Provisional; Region: PRK07067
1185652014378	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652014379	NAD(P) binding site [chemical binding]; other site
1185652014380	active site
1185652014381	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1185652014382	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652014383	Walker A/P-loop; other site
1185652014384	ATP binding site [chemical binding]; other site
1185652014385	Q-loop/lid; other site
1185652014386	ABC transporter signature motif; other site
1185652014387	Walker B; other site
1185652014388	D-loop; other site
1185652014389	H-loop/switch region; other site
1185652014390	TOBE domain; Region: TOBE_2; pfam08402
1185652014391	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652014392	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652014393	dimer interface [polypeptide binding]; other site
1185652014394	conserved gate region; other site
1185652014395	putative PBP binding loops; other site
1185652014396	ABC-ATPase subunit interface; other site
1185652014397	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652014398	conserved gate region; other site
1185652014399	dimer interface [polypeptide binding]; other site
1185652014400	putative PBP binding loops; other site
1185652014401	ABC-ATPase subunit interface; other site
1185652014402	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652014403	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652014404	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1185652014405	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1185652014406	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1185652014407	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
1185652014408	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
1185652014409	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
1185652014410	homodimer interface [polypeptide binding]; other site
1185652014411	active site
1185652014412	FMN binding site [chemical binding]; other site
1185652014413	substrate binding site [chemical binding]; other site
1185652014414	4Fe-4S binding domain; Region: Fer4_6; pfam12837
1185652014415	4Fe-4S binding domain; Region: Fer4; pfam00037
1185652014416	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
1185652014417	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1185652014418	putative NAD(P) binding site [chemical binding]; other site
1185652014419	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652014420	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652014421	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652014422	dimerization interface [polypeptide binding]; other site
1185652014423	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
1185652014424	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652014425	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
1185652014426	allantoate amidohydrolase; Reviewed; Region: PRK12893
1185652014427	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1185652014428	active site
1185652014429	metal binding site [ion binding]; metal-binding site
1185652014430	dimer interface [polypeptide binding]; other site
1185652014431	phenylhydantoinase; Validated; Region: PRK08323
1185652014432	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
1185652014433	tetramer interface [polypeptide binding]; other site
1185652014434	active site
1185652014435	Predicted mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: COG4101
1185652014436	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1185652014437	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1185652014438	Walker A/P-loop; other site
1185652014439	ATP binding site [chemical binding]; other site
1185652014440	Q-loop/lid; other site
1185652014441	ABC transporter signature motif; other site
1185652014442	Walker B; other site
1185652014443	D-loop; other site
1185652014444	H-loop/switch region; other site
1185652014445	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1185652014446	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652014447	dimer interface [polypeptide binding]; other site
1185652014448	conserved gate region; other site
1185652014449	putative PBP binding loops; other site
1185652014450	ABC-ATPase subunit interface; other site
1185652014451	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1185652014452	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652014453	dimer interface [polypeptide binding]; other site
1185652014454	conserved gate region; other site
1185652014455	putative PBP binding loops; other site
1185652014456	ABC-ATPase subunit interface; other site
1185652014457	NMT1/THI5 like; Region: NMT1; pfam09084
1185652014458	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1185652014459	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1185652014460	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652014461	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1185652014462	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1185652014463	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1185652014464	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1185652014465	UreF; Region: UreF; pfam01730
1185652014466	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1185652014467	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
1185652014468	dimer interface [polypeptide binding]; other site
1185652014469	catalytic residues [active]
1185652014470	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1185652014471	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1185652014472	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
1185652014473	catalytic triad [active]
1185652014474	dimer interface [polypeptide binding]; other site
1185652014475	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1185652014476	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1185652014477	subunit interactions [polypeptide binding]; other site
1185652014478	active site
1185652014479	flap region; other site
1185652014480	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
1185652014481	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1185652014482	gamma-beta subunit interface [polypeptide binding]; other site
1185652014483	alpha-beta subunit interface [polypeptide binding]; other site
1185652014484	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
1185652014485	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
1185652014486	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1185652014487	alpha-gamma subunit interface [polypeptide binding]; other site
1185652014488	beta-gamma subunit interface [polypeptide binding]; other site
1185652014489	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
1185652014490	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1185652014491	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1185652014492	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1185652014493	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1185652014494	MarR family; Region: MarR; pfam01047
1185652014495	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963
1185652014496	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1185652014497	dimer interface [polypeptide binding]; other site
1185652014498	active site
1185652014499	CoA binding pocket [chemical binding]; other site
1185652014500	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
1185652014501	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1185652014502	inhibitor-cofactor binding pocket; inhibition site
1185652014503	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652014504	catalytic residue [active]
1185652014505	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1185652014506	AAA domain; Region: AAA_26; pfam13500
1185652014507	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1185652014508	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1185652014509	catalytic residue [active]
1185652014510	biotin synthase; Provisional; Region: PRK15108
1185652014511	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1185652014512	FeS/SAM binding site; other site
1185652014513	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1185652014514	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1185652014515	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1185652014516	dimerization interface [polypeptide binding]; other site
1185652014517	ligand binding site [chemical binding]; other site
1185652014518	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1185652014519	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1185652014520	Walker A/P-loop; other site
1185652014521	ATP binding site [chemical binding]; other site
1185652014522	Q-loop/lid; other site
1185652014523	ABC transporter signature motif; other site
1185652014524	Walker B; other site
1185652014525	D-loop; other site
1185652014526	H-loop/switch region; other site
1185652014527	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1185652014528	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1185652014529	Walker A/P-loop; other site
1185652014530	ATP binding site [chemical binding]; other site
1185652014531	Q-loop/lid; other site
1185652014532	ABC transporter signature motif; other site
1185652014533	Walker B; other site
1185652014534	D-loop; other site
1185652014535	H-loop/switch region; other site
1185652014536	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
1185652014537	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
1185652014538	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1185652014539	TM-ABC transporter signature motif; other site
1185652014540	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652014541	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1185652014542	TM-ABC transporter signature motif; other site
1185652014543	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1185652014544	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1185652014545	active site
1185652014546	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652014547	active site
1185652014548	phosphorylation site [posttranslational modification]
1185652014549	intermolecular recognition site; other site
1185652014550	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1185652014551	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1185652014552	ligand binding site [chemical binding]; other site
1185652014553	flexible hinge region; other site
1185652014554	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1185652014555	putative switch regulator; other site
1185652014556	non-specific DNA interactions [nucleotide binding]; other site
1185652014557	DNA binding site [nucleotide binding]
1185652014558	sequence specific DNA binding site [nucleotide binding]; other site
1185652014559	putative cAMP binding site [chemical binding]; other site
1185652014560	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
1185652014561	classical (c) SDRs; Region: SDR_c; cd05233
1185652014562	NAD(P) binding site [chemical binding]; other site
1185652014563	active site
1185652014564	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1185652014565	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652014566	Zn binding site [ion binding]; other site
1185652014567	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1185652014568	Zn binding site [ion binding]; other site
1185652014569	Predicted esterase [General function prediction only]; Region: COG0400
1185652014570	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1185652014571	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1185652014572	Predicted flavoprotein [General function prediction only]; Region: COG0431
1185652014573	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1185652014574	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652014575	Zn binding site [ion binding]; other site
1185652014576	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1185652014577	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652014578	Zn binding site [ion binding]; other site
1185652014579	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1185652014580	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
1185652014581	putative active site [active]
1185652014582	catalytic triad [active]
1185652014583	putative dimer interface [polypeptide binding]; other site
1185652014584	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1185652014585	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652014586	dimer interface [polypeptide binding]; other site
1185652014587	conserved gate region; other site
1185652014588	putative PBP binding loops; other site
1185652014589	ABC-ATPase subunit interface; other site
1185652014590	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652014591	putative PBP binding loops; other site
1185652014592	ABC-ATPase subunit interface; other site
1185652014593	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1185652014594	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652014595	Walker A/P-loop; other site
1185652014596	ATP binding site [chemical binding]; other site
1185652014597	Q-loop/lid; other site
1185652014598	ABC transporter signature motif; other site
1185652014599	Walker B; other site
1185652014600	D-loop; other site
1185652014601	H-loop/switch region; other site
1185652014602	TOBE domain; Region: TOBE_2; pfam08402
1185652014603	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1185652014604	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1185652014605	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1185652014606	agmatinase; Region: agmatinase; TIGR01230
1185652014607	oligomer interface [polypeptide binding]; other site
1185652014608	putative active site [active]
1185652014609	Mn binding site [ion binding]; other site
1185652014610	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1185652014611	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652014612	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652014613	dimerization interface [polypeptide binding]; other site
1185652014614	hypothetical protein; Provisional; Region: PRK07550
1185652014615	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652014616	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652014617	homodimer interface [polypeptide binding]; other site
1185652014618	catalytic residue [active]
1185652014619	EamA-like transporter family; Region: EamA; pfam00892
1185652014620	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1185652014621	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1185652014622	NAD binding site [chemical binding]; other site
1185652014623	catalytic residues [active]
1185652014624	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1185652014625	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1185652014626	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652014627	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1185652014628	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1185652014629	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652014630	DNA-binding site [nucleotide binding]; DNA binding site
1185652014631	FCD domain; Region: FCD; pfam07729
1185652014632	hypothetical protein; Provisional; Region: PRK05968
1185652014633	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1185652014634	homodimer interface [polypeptide binding]; other site
1185652014635	substrate-cofactor binding pocket; other site
1185652014636	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652014637	catalytic residue [active]
1185652014638	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652014639	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652014640	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652014641	dimer interface [polypeptide binding]; other site
1185652014642	conserved gate region; other site
1185652014643	putative PBP binding loops; other site
1185652014644	ABC-ATPase subunit interface; other site
1185652014645	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652014646	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652014647	dimer interface [polypeptide binding]; other site
1185652014648	conserved gate region; other site
1185652014649	putative PBP binding loops; other site
1185652014650	ABC-ATPase subunit interface; other site
1185652014651	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1185652014652	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652014653	Walker A/P-loop; other site
1185652014654	ATP binding site [chemical binding]; other site
1185652014655	Q-loop/lid; other site
1185652014656	ABC transporter signature motif; other site
1185652014657	Walker B; other site
1185652014658	D-loop; other site
1185652014659	H-loop/switch region; other site
1185652014660	TOBE domain; Region: TOBE_2; pfam08402
1185652014661	Cytochrome c2 [Energy production and conversion]; Region: COG3474
1185652014662	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
1185652014663	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
1185652014664	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1185652014665	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1185652014666	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
1185652014667	Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865
1185652014668	Subunit I/III interface [polypeptide binding]; other site
1185652014669	Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864
1185652014670	Subunit I/III interface [polypeptide binding]; other site
1185652014671	Predicted small integral membrane protein [Function unknown]; Region: COG5605
1185652014672	Predicted transcriptional regulator [Transcription]; Region: COG1959
1185652014673	Transcriptional regulator; Region: Rrf2; pfam02082
1185652014674	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1185652014675	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1185652014676	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1185652014677	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1185652014678	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1185652014679	Walker A/P-loop; other site
1185652014680	ATP binding site [chemical binding]; other site
1185652014681	Q-loop/lid; other site
1185652014682	ABC transporter signature motif; other site
1185652014683	Walker B; other site
1185652014684	D-loop; other site
1185652014685	H-loop/switch region; other site
1185652014686	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1185652014687	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652014688	dimer interface [polypeptide binding]; other site
1185652014689	conserved gate region; other site
1185652014690	putative PBP binding loops; other site
1185652014691	ABC-ATPase subunit interface; other site
1185652014692	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1185652014693	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
1185652014694	active site
1185652014695	dimer interface [polypeptide binding]; other site
1185652014696	non-prolyl cis peptide bond; other site
1185652014697	insertion regions; other site
1185652014698	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1185652014699	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652014700	substrate binding pocket [chemical binding]; other site
1185652014701	membrane-bound complex binding site; other site
1185652014702	hinge residues; other site
1185652014703	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652014704	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1185652014705	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
1185652014706	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1185652014707	Cupin domain; Region: Cupin_2; pfam07883
1185652014708	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1185652014709	substrate binding site [chemical binding]; other site
1185652014710	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
1185652014711	oxyanion hole (OAH) forming residues; other site
1185652014712	trimer interface [polypeptide binding]; other site
1185652014713	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1185652014714	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1185652014715	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1185652014716	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1185652014717	Walker A/P-loop; other site
1185652014718	ATP binding site [chemical binding]; other site
1185652014719	Q-loop/lid; other site
1185652014720	ABC transporter signature motif; other site
1185652014721	Walker B; other site
1185652014722	D-loop; other site
1185652014723	H-loop/switch region; other site
1185652014724	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1185652014725	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1185652014726	Walker A/P-loop; other site
1185652014727	ATP binding site [chemical binding]; other site
1185652014728	Q-loop/lid; other site
1185652014729	ABC transporter signature motif; other site
1185652014730	Walker B; other site
1185652014731	D-loop; other site
1185652014732	H-loop/switch region; other site
1185652014733	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1185652014734	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1185652014735	TM-ABC transporter signature motif; other site
1185652014736	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652014737	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1185652014738	TM-ABC transporter signature motif; other site
1185652014739	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1185652014740	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
1185652014741	putative ligand binding site [chemical binding]; other site
1185652014742	phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288
1185652014743	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1185652014744	NAD(P) binding site [chemical binding]; other site
1185652014745	catalytic residues [active]
1185652014746	enoyl-CoA hydratase; Provisional; Region: PRK08140
1185652014747	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1185652014748	substrate binding site [chemical binding]; other site
1185652014749	oxyanion hole (OAH) forming residues; other site
1185652014750	trimer interface [polypeptide binding]; other site
1185652014751	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1185652014752	CoenzymeA binding site [chemical binding]; other site
1185652014753	subunit interaction site [polypeptide binding]; other site
1185652014754	PHB binding site; other site
1185652014755	Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913
1185652014756	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
1185652014757	active site
1185652014758	AMP binding site [chemical binding]; other site
1185652014759	homodimer interface [polypeptide binding]; other site
1185652014760	acyl-activating enzyme (AAE) consensus motif; other site
1185652014761	CoA binding site [chemical binding]; other site
1185652014762	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1185652014763	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652014764	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
1185652014765	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
1185652014766	substrate binding site [chemical binding]; other site
1185652014767	dimer interface [polypeptide binding]; other site
1185652014768	NADP binding site [chemical binding]; other site
1185652014769	catalytic residues [active]
1185652014770	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
1185652014771	substrate binding site [chemical binding]; other site
1185652014772	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
1185652014773	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
1185652014774	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1185652014775	FAD binding pocket [chemical binding]; other site
1185652014776	FAD binding motif [chemical binding]; other site
1185652014777	phosphate binding motif [ion binding]; other site
1185652014778	beta-alpha-beta structure motif; other site
1185652014779	NAD(p) ribose binding residues [chemical binding]; other site
1185652014780	NAD binding pocket [chemical binding]; other site
1185652014781	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1185652014782	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1185652014783	catalytic loop [active]
1185652014784	iron binding site [ion binding]; other site
1185652014785	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1185652014786	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
1185652014787	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
1185652014788	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
1185652014789	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
1185652014790	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
1185652014791	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
1185652014792	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1185652014793	dimer interface [polypeptide binding]; other site
1185652014794	active site
1185652014795	Uncharacterized conserved protein [Function unknown]; Region: COG3025
1185652014796	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
1185652014797	putative active site [active]
1185652014798	putative triphosphate binding site [ion binding]; other site
1185652014799	putative metal binding residues [ion binding]; other site
1185652014800	CHAD domain; Region: CHAD; pfam05235
1185652014801	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
1185652014802	GAF domain; Region: GAF; pfam01590
1185652014803	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1185652014804	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1185652014805	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1185652014806	aspartate kinase; Reviewed; Region: PRK06635
1185652014807	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1185652014808	putative nucleotide binding site [chemical binding]; other site
1185652014809	putative catalytic residues [active]
1185652014810	putative Mg ion binding site [ion binding]; other site
1185652014811	putative aspartate binding site [chemical binding]; other site
1185652014812	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1185652014813	putative allosteric regulatory site; other site
1185652014814	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1185652014815	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652014816	S-adenosylmethionine binding site [chemical binding]; other site
1185652014817	RibD C-terminal domain; Region: RibD_C; cl17279
1185652014818	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1185652014819	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
1185652014820	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652014821	S-adenosylmethionine binding site [chemical binding]; other site
1185652014822	SnoaL-like domain; Region: SnoaL_2; pfam12680
1185652014823	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319
1185652014824	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
1185652014825	nitrilase; Region: PLN02798
1185652014826	putative active site [active]
1185652014827	catalytic triad [active]
1185652014828	dimer interface [polypeptide binding]; other site
1185652014829	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
1185652014830	GSH binding site [chemical binding]; other site
1185652014831	catalytic residues [active]
1185652014832	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1185652014833	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1185652014834	active site
1185652014835	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1185652014836	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
1185652014837	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1185652014838	active site
1185652014839	8-oxo-dGMP binding site [chemical binding]; other site
1185652014840	nudix motif; other site
1185652014841	metal binding site [ion binding]; metal-binding site
1185652014842	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652014843	Coenzyme A binding pocket [chemical binding]; other site
1185652014844	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1185652014845	heterotetramer interface [polypeptide binding]; other site
1185652014846	active site pocket [active]
1185652014847	cleavage site
1185652014848	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002
1185652014849	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1185652014850	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1185652014851	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1185652014852	SEC-C motif; Region: SEC-C; pfam02810
1185652014853	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1185652014854	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1185652014855	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1185652014856	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1185652014857	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971
1185652014858	active site
1185652014859	acyl-activating enzyme (AAE) consensus motif; other site
1185652014860	putative CoA binding site [chemical binding]; other site
1185652014861	AMP binding site [chemical binding]; other site
1185652014862	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1185652014863	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1185652014864	active site
1185652014865	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1185652014866	endonuclease III; Region: ENDO3c; smart00478
1185652014867	minor groove reading motif; other site
1185652014868	helix-hairpin-helix signature motif; other site
1185652014869	substrate binding pocket [chemical binding]; other site
1185652014870	active site
1185652014871	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
1185652014872	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
1185652014873	active site
1185652014874	HIGH motif; other site
1185652014875	nucleotide binding site [chemical binding]; other site
1185652014876	active site
1185652014877	KMSKS motif; other site
1185652014878	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
1185652014879	short chain dehydrogenase; Provisional; Region: PRK05993
1185652014880	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1185652014881	NADP binding site [chemical binding]; other site
1185652014882	active site
1185652014883	steroid binding site; other site
1185652014884	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
1185652014885	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
1185652014886	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1185652014887	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1185652014888	Ligand binding site [chemical binding]; other site
1185652014889	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1185652014890	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1185652014891	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1185652014892	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1185652014893	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
1185652014894	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1185652014895	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1185652014896	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1185652014897	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1185652014898	catalytic residues [active]
1185652014899	argininosuccinate lyase; Provisional; Region: PRK00855
1185652014900	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1185652014901	active sites [active]
1185652014902	tetramer interface [polypeptide binding]; other site
1185652014903	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
1185652014904	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1185652014905	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1185652014906	active site
1185652014907	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1185652014908	substrate binding site [chemical binding]; other site
1185652014909	catalytic residues [active]
1185652014910	dimer interface [polypeptide binding]; other site
1185652014911	TIGR02302 family protein; Region: aProt_lowcomp
1185652014912	Response regulator receiver domain; Region: Response_reg; pfam00072
1185652014913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652014914	active site
1185652014915	phosphorylation site [posttranslational modification]
1185652014916	intermolecular recognition site; other site
1185652014917	dimerization interface [polypeptide binding]; other site
1185652014918	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1185652014919	active site
1185652014920	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
1185652014921	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1185652014922	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1185652014923	Walker A/P-loop; other site
1185652014924	ATP binding site [chemical binding]; other site
1185652014925	Q-loop/lid; other site
1185652014926	ABC transporter signature motif; other site
1185652014927	Walker B; other site
1185652014928	D-loop; other site
1185652014929	H-loop/switch region; other site
1185652014930	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1185652014931	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1185652014932	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1185652014933	putative active site [active]
1185652014934	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1185652014935	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1185652014936	putative acyl-acceptor binding pocket; other site
1185652014937	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
1185652014938	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1185652014939	putative active site pocket [active]
1185652014940	dimerization interface [polypeptide binding]; other site
1185652014941	putative catalytic residue [active]
1185652014942	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093
1185652014943	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
1185652014944	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
1185652014945	prephenate dehydrogenase; Validated; Region: PRK08507
1185652014946	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
1185652014947	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652014948	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652014949	homodimer interface [polypeptide binding]; other site
1185652014950	catalytic residue [active]
1185652014951	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1185652014952	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652014953	Uncharacterized conserved protein [Function unknown]; Region: COG3542
1185652014954	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
1185652014955	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1185652014956	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
1185652014957	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
1185652014958	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
1185652014959	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
1185652014960	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
1185652014961	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
1185652014962	metal ion-dependent adhesion site (MIDAS); other site
1185652014963	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
1185652014964	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
1185652014965	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1185652014966	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
1185652014967	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1185652014968	HSP70 interaction site [polypeptide binding]; other site
1185652014969	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
1185652014970	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
1185652014971	Domain of unknown function DUF21; Region: DUF21; pfam01595
1185652014972	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1185652014973	Transporter associated domain; Region: CorC_HlyC; smart01091
1185652014974	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1185652014975	active site
1185652014976	dimer interface [polypeptide binding]; other site
1185652014977	metal binding site [ion binding]; metal-binding site
1185652014978	shikimate kinase; Provisional; Region: PRK13946
1185652014979	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1185652014980	ADP binding site [chemical binding]; other site
1185652014981	magnesium binding site [ion binding]; other site
1185652014982	putative shikimate binding site; other site
1185652014983	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1185652014984	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1185652014985	active site
1185652014986	DNA binding site [nucleotide binding]
1185652014987	Int/Topo IB signature motif; other site
1185652014988	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1185652014989	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1185652014990	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
1185652014991	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1185652014992	CPxP  motif; other site
1185652014993	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1185652014994	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1185652014995	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1185652014996	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1185652014997	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1185652014998	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1185652014999	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1185652015000	metal binding site [ion binding]; metal-binding site
1185652015001	putative dimer interface [polypeptide binding]; other site
1185652015002	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652015003	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652015004	putative DNA binding site [nucleotide binding]; other site
1185652015005	putative Zn2+ binding site [ion binding]; other site
1185652015006	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652015007	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1185652015008	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1185652015009	putative NAD(P) binding site [chemical binding]; other site
1185652015010	putative substrate binding site [chemical binding]; other site
1185652015011	catalytic Zn binding site [ion binding]; other site
1185652015012	structural Zn binding site [ion binding]; other site
1185652015013	dimer interface [polypeptide binding]; other site
1185652015014	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1185652015015	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1185652015016	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652015017	hypothetical protein; Provisional; Region: PRK06149
1185652015018	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1185652015019	active site
1185652015020	ATP binding site [chemical binding]; other site
1185652015021	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1185652015022	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1185652015023	inhibitor-cofactor binding pocket; inhibition site
1185652015024	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652015025	catalytic residue [active]
1185652015026	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
1185652015027	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652015028	DNA-binding site [nucleotide binding]; DNA binding site
1185652015029	UTRA domain; Region: UTRA; pfam07702
1185652015030	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
1185652015031	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
1185652015032	active site
1185652015033	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1185652015034	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1185652015035	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652015036	dimer interface [polypeptide binding]; other site
1185652015037	conserved gate region; other site
1185652015038	putative PBP binding loops; other site
1185652015039	ABC-ATPase subunit interface; other site
1185652015040	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652015041	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1185652015042	Walker A/P-loop; other site
1185652015043	ATP binding site [chemical binding]; other site
1185652015044	Q-loop/lid; other site
1185652015045	ABC transporter signature motif; other site
1185652015046	Walker B; other site
1185652015047	D-loop; other site
1185652015048	H-loop/switch region; other site
1185652015049	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1185652015050	active sites [active]
1185652015051	tetramer interface [polypeptide binding]; other site
1185652015052	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758
1185652015053	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1185652015054	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1185652015055	active site
1185652015056	catalytic tetrad [active]
1185652015057	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
1185652015058	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1185652015059	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652015060	S-adenosylmethionine binding site [chemical binding]; other site
1185652015061	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652015062	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
1185652015063	NAD binding site [chemical binding]; other site
1185652015064	putative substrate binding site 2 [chemical binding]; other site
1185652015065	putative substrate binding site 1 [chemical binding]; other site
1185652015066	active site
1185652015067	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
1185652015068	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1185652015069	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1185652015070	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
1185652015071	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1185652015072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
1185652015073	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1185652015074	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1185652015075	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1185652015076	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652015077	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
1185652015078	NAD binding site [chemical binding]; other site
1185652015079	homotetramer interface [polypeptide binding]; other site
1185652015080	homodimer interface [polypeptide binding]; other site
1185652015081	active site
1185652015082	substrate binding site [chemical binding]; other site
1185652015083	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652015084	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652015085	NAD(P) binding site [chemical binding]; other site
1185652015086	active site
1185652015087	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1185652015088	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269
1185652015089	putative NAD(P) binding site [chemical binding]; other site
1185652015090	catalytic Zn binding site [ion binding]; other site
1185652015091	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652015092	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652015093	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1185652015094	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1185652015095	ATP binding site [chemical binding]; other site
1185652015096	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
1185652015097	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
1185652015098	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1185652015099	catalytic core [active]
1185652015100	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
1185652015101	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
1185652015102	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
1185652015103	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1185652015104	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1185652015105	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1185652015106	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1185652015107	AP (apurinic/apyrimidinic) site pocket; other site
1185652015108	DNA interaction; other site
1185652015109	Metal-binding active site; metal-binding site
1185652015110	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1185652015111	Glycerophosphodiester phosphodiesterase domain of putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_pAtGDE_like; cd08565
1185652015112	active site
1185652015113	catalytic site [active]
1185652015114	metal binding site [ion binding]; metal-binding site
1185652015115	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1185652015116	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652015117	dimer interface [polypeptide binding]; other site
1185652015118	conserved gate region; other site
1185652015119	putative PBP binding loops; other site
1185652015120	ABC-ATPase subunit interface; other site
1185652015121	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1185652015122	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652015123	dimer interface [polypeptide binding]; other site
1185652015124	conserved gate region; other site
1185652015125	putative PBP binding loops; other site
1185652015126	ABC-ATPase subunit interface; other site
1185652015127	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1185652015128	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652015129	Walker A/P-loop; other site
1185652015130	ATP binding site [chemical binding]; other site
1185652015131	Q-loop/lid; other site
1185652015132	ABC transporter signature motif; other site
1185652015133	Walker B; other site
1185652015134	D-loop; other site
1185652015135	H-loop/switch region; other site
1185652015136	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1185652015137	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1185652015138	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652015139	Walker A/P-loop; other site
1185652015140	ATP binding site [chemical binding]; other site
1185652015141	Q-loop/lid; other site
1185652015142	ABC transporter signature motif; other site
1185652015143	Walker B; other site
1185652015144	D-loop; other site
1185652015145	H-loop/switch region; other site
1185652015146	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1185652015147	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1185652015148	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515
1185652015149	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1185652015150	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1185652015151	DNA binding residues [nucleotide binding]
1185652015152	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1185652015153	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1185652015154	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1185652015155	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1185652015156	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1185652015157	DNA binding residues [nucleotide binding]
1185652015158	Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561
1185652015159	active site
1185652015160	catalytic triad [active]
1185652015161	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1185652015162	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652015163	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1185652015164	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
1185652015165	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1185652015166	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652015167	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652015168	NAD(P) binding site [chemical binding]; other site
1185652015169	active site
1185652015170	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
1185652015171	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
1185652015172	ZIP Zinc transporter; Region: Zip; pfam02535
1185652015173	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
1185652015174	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
1185652015175	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173
1185652015176	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1185652015177	Cytochrome c553 [Energy production and conversion]; Region: COG2863
1185652015178	Cytochrome c; Region: Cytochrom_C; cl11414
1185652015179	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
1185652015180	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1185652015181	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
1185652015182	Cytochrome c; Region: Cytochrom_C; pfam00034
1185652015183	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
1185652015184	D-pathway; other site
1185652015185	Low-spin heme binding site [chemical binding]; other site
1185652015186	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1185652015187	Putative water exit pathway; other site
1185652015188	Binuclear center (active site) [active]
1185652015189	K-pathway; other site
1185652015190	Putative proton exit pathway; other site
1185652015191	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
1185652015192	Subunit I/III interface [polypeptide binding]; other site
1185652015193	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1185652015194	Cytochrome c; Region: Cytochrom_C; cl11414
1185652015195	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1185652015196	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1185652015197	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1185652015198	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1185652015199	catalytic loop [active]
1185652015200	iron binding site [ion binding]; other site
1185652015201	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1185652015202	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1185652015203	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1185652015204	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1185652015205	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1185652015206	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1185652015207	aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433
1185652015208	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1185652015209	catalytic loop [active]
1185652015210	iron binding site [ion binding]; other site
1185652015211	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1185652015212	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1185652015213	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
1185652015214	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1185652015215	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1185652015216	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1185652015217	Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935
1185652015218	TIGR02588 family protein; Region: TIGR02588
1185652015219	Uncharacterized conserved protein [Function unknown]; Region: COG5482
1185652015220	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652015221	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652015222	dimer interface [polypeptide binding]; other site
1185652015223	conserved gate region; other site
1185652015224	putative PBP binding loops; other site
1185652015225	ABC-ATPase subunit interface; other site
1185652015226	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
1185652015227	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652015228	dimer interface [polypeptide binding]; other site
1185652015229	putative PBP binding loops; other site
1185652015230	ABC-ATPase subunit interface; other site
1185652015231	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652015232	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652015233	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652015234	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1185652015235	substrate binding pocket [chemical binding]; other site
1185652015236	dimerization interface [polypeptide binding]; other site
1185652015237	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803
1185652015238	Helix-turn-helix domain; Region: HTH_28; pfam13518
1185652015239	Winged helix-turn helix; Region: HTH_29; pfam13551
1185652015240	Homeodomain-like domain; Region: HTH_32; pfam13565
1185652015241	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1185652015242	Integrase core domain; Region: rve; pfam00665
1185652015243	Integrase core domain; Region: rve_3; pfam13683
1185652015244	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
1185652015245	Predicted acetyltransferase [General function prediction only]; Region: COG2388
1185652015246	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652015247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652015248	active site
1185652015249	phosphorylation site [posttranslational modification]
1185652015250	intermolecular recognition site; other site
1185652015251	dimerization interface [polypeptide binding]; other site
1185652015252	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652015253	DNA binding site [nucleotide binding]
1185652015254	Response regulator receiver domain; Region: Response_reg; pfam00072
1185652015255	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652015256	active site
1185652015257	phosphorylation site [posttranslational modification]
1185652015258	intermolecular recognition site; other site
1185652015259	dimerization interface [polypeptide binding]; other site
1185652015260	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385
1185652015261	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5400
1185652015262	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1185652015263	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1185652015264	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
1185652015265	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1185652015266	Protein of unknown function (DUF2433); Region: DUF2433; pfam10360
1185652015267	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1185652015268	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1185652015269	RNA binding surface [nucleotide binding]; other site
1185652015270	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1185652015271	active site
1185652015272	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
1185652015273	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1185652015274	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1185652015275	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1185652015276	DNA binding residues [nucleotide binding]
1185652015277	cell division protein ZipA; Provisional; Region: PRK03427
1185652015278	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1185652015279	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1185652015280	GDP-binding site [chemical binding]; other site
1185652015281	ACT binding site; other site
1185652015282	IMP binding site; other site
1185652015283	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1185652015284	EamA-like transporter family; Region: EamA; pfam00892
1185652015285	EamA-like transporter family; Region: EamA; pfam00892
1185652015286	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
1185652015287	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1185652015288	ligand binding site [chemical binding]; other site
1185652015289	NAD binding site [chemical binding]; other site
1185652015290	dimerization interface [polypeptide binding]; other site
1185652015291	catalytic site [active]
1185652015292	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1185652015293	putative L-serine binding site [chemical binding]; other site
1185652015294	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
1185652015295	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1185652015296	catalytic residue [active]
1185652015297	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
1185652015298	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
1185652015299	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
1185652015300	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1185652015301	active site
1185652015302	substrate binding site [chemical binding]; other site
1185652015303	metal binding site [ion binding]; metal-binding site
1185652015304	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652015305	Walker B motif; other site
1185652015306	arginine finger; other site
1185652015307	Peptidase family M41; Region: Peptidase_M41; pfam01434
1185652015308	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1185652015309	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1185652015310	Ligand Binding Site [chemical binding]; other site
1185652015311	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
1185652015312	Tetratricopeptide repeat; Region: TPR_6; pfam13174
1185652015313	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1185652015314	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1185652015315	ligand binding site [chemical binding]; other site
1185652015316	translocation protein TolB; Provisional; Region: tolB; PRK05137
1185652015317	TolB amino-terminal domain; Region: TolB_N; pfam04052
1185652015318	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1185652015319	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1185652015320	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1185652015321	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1185652015322	TolR protein; Region: tolR; TIGR02801
1185652015323	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1185652015324	TolQ protein; Region: tolQ; TIGR02796
1185652015325	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
1185652015326	Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666
1185652015327	DNA binding site [nucleotide binding]
1185652015328	heterodimer interface [polypeptide binding]; other site
1185652015329	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
1185652015330	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
1185652015331	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1185652015332	active site
1185652015333	DNA binding site [nucleotide binding]
1185652015334	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1185652015335	DNA binding site [nucleotide binding]
1185652015336	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
1185652015337	nucleotide binding site [chemical binding]; other site
1185652015338	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1185652015339	active site
1185652015340	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652015341	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652015342	NAD(P) binding site [chemical binding]; other site
1185652015343	active site
1185652015344	Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537
1185652015345	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
1185652015346	substrate binding site; other site
1185652015347	Manganese binding site; other site
1185652015348	dimer interface; other site
1185652015349	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652015350	extended (e) SDRs; Region: SDR_e; cd08946
1185652015351	NAD(P) binding site [chemical binding]; other site
1185652015352	active site
1185652015353	substrate binding site [chemical binding]; other site
1185652015354	phosphodiesterase YaeI; Provisional; Region: PRK11340
1185652015355	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1185652015356	putative active site [active]
1185652015357	putative metal binding site [ion binding]; other site
1185652015358	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1185652015359	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652015360	Walker A motif; other site
1185652015361	ATP binding site [chemical binding]; other site
1185652015362	Walker B motif; other site
1185652015363	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1185652015364	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1185652015365	RuvA N terminal domain; Region: RuvA_N; pfam01330
1185652015366	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1185652015367	active site
1185652015368	putative DNA-binding cleft [nucleotide binding]; other site
1185652015369	dimer interface [polypeptide binding]; other site
1185652015370	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1185652015371	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1185652015372	hypothetical protein; Validated; Region: PRK00110
1185652015373	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
1185652015374	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1185652015375	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1185652015376	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1185652015377	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1185652015378	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652015379	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1185652015380	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1185652015381	putative active site [active]
1185652015382	metal binding site [ion binding]; metal-binding site
1185652015383	homodimer binding site [polypeptide binding]; other site
1185652015384	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
1185652015385	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1185652015386	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1185652015387	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652015388	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652015389	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652015390	dimerization interface [polypeptide binding]; other site
1185652015391	Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division,    chromosome partitioning]; Region: zapA; COG3027
1185652015392	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
1185652015393	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1185652015394	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1185652015395	TPP-binding site [chemical binding]; other site
1185652015396	dimer interface [polypeptide binding]; other site
1185652015397	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1185652015398	PYR/PP interface [polypeptide binding]; other site
1185652015399	dimer interface [polypeptide binding]; other site
1185652015400	TPP binding site [chemical binding]; other site
1185652015401	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1185652015402	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1185652015403	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1185652015404	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1185652015405	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554
1185652015406	Phosphoglycerate kinase; Region: PGK; pfam00162
1185652015407	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1185652015408	substrate binding site [chemical binding]; other site
1185652015409	hinge regions; other site
1185652015410	ADP binding site [chemical binding]; other site
1185652015411	catalytic site [active]
1185652015412	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
1185652015413	active site
1185652015414	intersubunit interface [polypeptide binding]; other site
1185652015415	catalytic residue [active]
1185652015416	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1185652015417	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652015418	cyclase homology domain; Region: CHD; cd07302
1185652015419	nucleotidyl binding site; other site
1185652015420	metal binding site [ion binding]; metal-binding site
1185652015421	dimer interface [polypeptide binding]; other site
1185652015422	Predicted integral membrane protein [Function unknown]; Region: COG5616
1185652015423	TPR repeat; Region: TPR_11; pfam13414
1185652015424	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652015425	TPR motif; other site
1185652015426	TPR repeat; Region: TPR_11; pfam13414
1185652015427	binding surface
1185652015428	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652015429	binding surface
1185652015430	TPR motif; other site
1185652015431	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1185652015432	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652015433	TPR motif; other site
1185652015434	binding surface
1185652015435	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652015436	putative substrate translocation pore; other site
1185652015437	Protein of unknown function (DUF1192); Region: DUF1192; pfam06698
1185652015438	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317
1185652015439	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
1185652015440	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1185652015441	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652015442	Walker A/P-loop; other site
1185652015443	ATP binding site [chemical binding]; other site
1185652015444	Q-loop/lid; other site
1185652015445	ABC transporter signature motif; other site
1185652015446	Walker B; other site
1185652015447	D-loop; other site
1185652015448	H-loop/switch region; other site
1185652015449	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1185652015450	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1185652015451	FAD binding domain; Region: FAD_binding_2; pfam00890
1185652015452	hypothetical protein; Validated; Region: PRK09039
1185652015453	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1185652015454	ligand binding site [chemical binding]; other site
1185652015455	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1185652015456	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1185652015457	active site
1185652015458	dimerization interface [polypeptide binding]; other site
1185652015459	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1185652015460	Sel1-like repeats; Region: SEL1; smart00671
1185652015461	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1185652015462	thiamine phosphate binding site [chemical binding]; other site
1185652015463	active site
1185652015464	pyrophosphate binding site [ion binding]; other site
1185652015465	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1185652015466	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652015467	dimerization interface [polypeptide binding]; other site
1185652015468	putative DNA binding site [nucleotide binding]; other site
1185652015469	putative Zn2+ binding site [ion binding]; other site
1185652015470	Uncharacterized small protein [Function unknown]; Region: COG5570
1185652015471	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
1185652015472	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1185652015473	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1185652015474	ATP-grasp domain; Region: ATP-grasp; pfam02222
1185652015475	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
1185652015476	TPR repeat; Region: TPR_11; pfam13414
1185652015477	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652015478	TPR motif; other site
1185652015479	TPR repeat; Region: TPR_11; pfam13414
1185652015480	binding surface
1185652015481	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1185652015482	pyruvate kinase; Provisional; Region: PRK06247
1185652015483	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1185652015484	domain interfaces; other site
1185652015485	active site
1185652015486	Predicted integral membrane protein [Function unknown]; Region: COG5480
1185652015487	Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931
1185652015488	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
1185652015489	hypothetical protein; Provisional; Region: PRK13694
1185652015490	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
1185652015491	Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951
1185652015492	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1185652015493	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652015494	active site
1185652015495	phosphorylation site [posttranslational modification]
1185652015496	intermolecular recognition site; other site
1185652015497	dimerization interface [polypeptide binding]; other site
1185652015498	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652015499	Walker A motif; other site
1185652015500	ATP binding site [chemical binding]; other site
1185652015501	Walker B motif; other site
1185652015502	arginine finger; other site
1185652015503	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1185652015504	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
1185652015505	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
1185652015506	active site
1185652015507	Zn binding site [ion binding]; other site
1185652015508	aminodeoxychorismate synthase; Provisional; Region: PRK07508
1185652015509	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1185652015510	hypothetical protein; Provisional; Region: PRK07546
1185652015511	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1185652015512	substrate-cofactor binding pocket; other site
1185652015513	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652015514	catalytic residue [active]
1185652015515	PAS fold; Region: PAS_7; pfam12860
1185652015516	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652015517	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652015518	metal binding site [ion binding]; metal-binding site
1185652015519	active site
1185652015520	I-site; other site
1185652015521	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
1185652015522	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
1185652015523	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
1185652015524	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1185652015525	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
1185652015526	active site
1185652015527	metal binding site [ion binding]; metal-binding site
1185652015528	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1185652015529	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
1185652015530	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1185652015531	ferrochelatase; Reviewed; Region: hemH; PRK00035
1185652015532	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1185652015533	C-terminal domain interface [polypeptide binding]; other site
1185652015534	active site
1185652015535	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1185652015536	active site
1185652015537	N-terminal domain interface [polypeptide binding]; other site
1185652015538	Glutaminase; Region: Glutaminase; cl00907
1185652015539	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1185652015540	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1185652015541	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1185652015542	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1185652015543	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
1185652015544	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
1185652015545	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1185652015546	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1185652015547	active site
1185652015548	tetramer interface; other site
1185652015549	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1185652015550	murein hydrolase B; Provisional; Region: PRK10760; cl17906
1185652015551	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1185652015552	SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829
1185652015553	active site
1185652015554	catalytic triad [active]
1185652015555	oxyanion hole [active]
1185652015556	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1185652015557	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652015558	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1185652015559	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1185652015560	active site
1185652015561	dimer interface [polypeptide binding]; other site
1185652015562	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1185652015563	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1185652015564	active site
1185652015565	FMN binding site [chemical binding]; other site
1185652015566	substrate binding site [chemical binding]; other site
1185652015567	3Fe-4S cluster binding site [ion binding]; other site
1185652015568	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1185652015569	domain interface; other site
1185652015570	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1185652015571	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
1185652015572	tetramer interface [polypeptide binding]; other site
1185652015573	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652015574	catalytic residue [active]
1185652015575	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1185652015576	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1185652015577	putative dimer interface [polypeptide binding]; other site
1185652015578	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1185652015579	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1185652015580	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1185652015581	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
1185652015582	active site
1185652015583	N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741
1185652015584	Response regulator receiver domain; Region: Response_reg; pfam00072
1185652015585	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652015586	active site
1185652015587	phosphorylation site [posttranslational modification]
1185652015588	intermolecular recognition site; other site
1185652015589	dimerization interface [polypeptide binding]; other site
1185652015590	carbonic anhydrase; Region: PLN03014
1185652015591	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
1185652015592	putative catalytic residues [active]
1185652015593	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1185652015594	Double zinc ribbon; Region: DZR; pfam12773
1185652015595	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1185652015596	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652015597	cyclase homology domain; Region: CHD; cd07302
1185652015598	nucleotidyl binding site; other site
1185652015599	metal binding site [ion binding]; metal-binding site
1185652015600	dimer interface [polypeptide binding]; other site
1185652015601	AAA ATPase domain; Region: AAA_16; pfam13191
1185652015602	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1185652015603	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1185652015604	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652015605	TPR motif; other site
1185652015606	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1185652015607	Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613
1185652015608	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1185652015609	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1185652015610	MarR family; Region: MarR_2; pfam12802
1185652015611	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1185652015612	MarR family; Region: MarR; pfam01047
1185652015613	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
1185652015614	Protein of unknown function (DUF1579); Region: DUF1579; pfam07617
1185652015615	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1185652015616	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1185652015617	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652015618	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652015619	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652015620	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652015621	dimerization interface [polypeptide binding]; other site
1185652015622	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1185652015623	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1185652015624	active site
1185652015625	catalytic tetrad [active]
1185652015626	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1185652015627	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1185652015628	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1185652015629	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
1185652015630	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
1185652015631	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1185652015632	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1185652015633	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1185652015634	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1185652015635	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1185652015636	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1185652015637	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1185652015638	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1185652015639	metal ion-dependent adhesion site (MIDAS); other site
1185652015640	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1185652015641	homodimer interface [polypeptide binding]; other site
1185652015642	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1185652015643	active site pocket [active]
1185652015644	glycogen branching enzyme; Provisional; Region: PRK05402
1185652015645	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1185652015646	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1185652015647	active site
1185652015648	catalytic site [active]
1185652015649	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1185652015650	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
1185652015651	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1185652015652	ligand binding site; other site
1185652015653	oligomer interface; other site
1185652015654	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1185652015655	dimer interface [polypeptide binding]; other site
1185652015656	N-terminal domain interface [polypeptide binding]; other site
1185652015657	sulfate 1 binding site; other site
1185652015658	glycogen synthase; Provisional; Region: glgA; PRK00654
1185652015659	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1185652015660	ADP-binding pocket [chemical binding]; other site
1185652015661	homodimer interface [polypeptide binding]; other site
1185652015662	phosphoglucomutase; Region: PLN02307
1185652015663	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
1185652015664	substrate binding site [chemical binding]; other site
1185652015665	dimer interface [polypeptide binding]; other site
1185652015666	active site
1185652015667	metal binding site [ion binding]; metal-binding site
1185652015668	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1185652015669	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1185652015670	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1185652015671	active site
1185652015672	catalytic site [active]
1185652015673	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
1185652015674	putative active site [active]
1185652015675	putative catalytic site [active]
1185652015676	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837
1185652015677	Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583
1185652015678	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
1185652015679	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1185652015680	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1185652015681	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
1185652015682	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
1185652015683	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1185652015684	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1185652015685	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652015686	TPR motif; other site
1185652015687	TPR repeat; Region: TPR_11; pfam13414
1185652015688	binding surface
1185652015689	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652015690	binding surface
1185652015691	TPR repeat; Region: TPR_11; pfam13414
1185652015692	TPR motif; other site
1185652015693	TPR repeat; Region: TPR_11; pfam13414
1185652015694	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652015695	binding surface
1185652015696	TPR motif; other site
1185652015697	TPR repeat; Region: TPR_11; pfam13414
1185652015698	Protein of unknown function (DUF992); Region: DUF992; pfam06186
1185652015699	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652015700	cyclase homology domain; Region: CHD; cd07302
1185652015701	nucleotidyl binding site; other site
1185652015702	metal binding site [ion binding]; metal-binding site
1185652015703	dimer interface [polypeptide binding]; other site
1185652015704	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
1185652015705	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1185652015706	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1185652015707	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1185652015708	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
1185652015709	ligand binding site [chemical binding]; other site
1185652015710	homodimer interface [polypeptide binding]; other site
1185652015711	NAD(P) binding site [chemical binding]; other site
1185652015712	trimer interface B [polypeptide binding]; other site
1185652015713	trimer interface A [polypeptide binding]; other site
1185652015714	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
1185652015715	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
1185652015716	PAS domain; Region: PAS; smart00091
1185652015717	PAS fold; Region: PAS_7; pfam12860
1185652015718	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652015719	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652015720	metal binding site [ion binding]; metal-binding site
1185652015721	active site
1185652015722	I-site; other site
1185652015723	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1185652015724	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
1185652015725	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1185652015726	catalytic triad [active]
1185652015727	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1185652015728	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
1185652015729	putative ligand binding site [chemical binding]; other site
1185652015730	NAD binding site [chemical binding]; other site
1185652015731	catalytic site [active]
1185652015732	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652015733	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652015734	DNA binding site [nucleotide binding]
1185652015735	domain linker motif; other site
1185652015736	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
1185652015737	putative dimerization interface [polypeptide binding]; other site
1185652015738	putative ligand binding site [chemical binding]; other site
1185652015739	MarR family; Region: MarR_2; cl17246
1185652015740	Creatinine amidohydrolase; Region: Creatininase; pfam02633
1185652015741	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1185652015742	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
1185652015743	P-loop, Walker A motif; other site
1185652015744	Base recognition motif; other site
1185652015745	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1185652015746	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1185652015747	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1185652015748	structural tetrad; other site
1185652015749	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1185652015750	Predicted acetyltransferase [General function prediction only]; Region: COG3153
1185652015751	Coenzyme A binding pocket [chemical binding]; other site
1185652015752	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1185652015753	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
1185652015754	dimer interface [polypeptide binding]; other site
1185652015755	active site
1185652015756	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1185652015757	catalytic residues [active]
1185652015758	substrate binding site [chemical binding]; other site
1185652015759	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652015760	LysR family transcriptional regulator; Provisional; Region: PRK14997
1185652015761	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1185652015762	putative effector binding pocket; other site
1185652015763	dimerization interface [polypeptide binding]; other site
1185652015764	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
1185652015765	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
1185652015766	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1185652015767	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1185652015768	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
1185652015769	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
1185652015770	putative metal binding site [ion binding]; other site
1185652015771	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
1185652015772	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1185652015773	active site
1185652015774	intersubunit interface [polypeptide binding]; other site
1185652015775	catalytic residue [active]
1185652015776	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
1185652015777	putative active site [active]
1185652015778	putative metal binding residues [ion binding]; other site
1185652015779	signature motif; other site
1185652015780	putative dimer interface [polypeptide binding]; other site
1185652015781	putative phosphate binding site [ion binding]; other site
1185652015782	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
1185652015783	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
1185652015784	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1185652015785	active site residue [active]
1185652015786	Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356
1185652015787	substrate binding site [chemical binding]; other site
1185652015788	Protein of unknown function (DUF521); Region: DUF521; pfam04412
1185652015789	Putative Aconitase X catalytic domain; Region: AcnX; cd01355
1185652015790	substrate binding site [chemical binding]; other site
1185652015791	ligand binding site [chemical binding]; other site
1185652015792	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1185652015793	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1185652015794	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1185652015795	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652015796	dimer interface [polypeptide binding]; other site
1185652015797	conserved gate region; other site
1185652015798	ABC-ATPase subunit interface; other site
1185652015799	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1185652015800	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1185652015801	Walker A/P-loop; other site
1185652015802	ATP binding site [chemical binding]; other site
1185652015803	Q-loop/lid; other site
1185652015804	ABC transporter signature motif; other site
1185652015805	Walker B; other site
1185652015806	D-loop; other site
1185652015807	H-loop/switch region; other site
1185652015808	NIL domain; Region: NIL; pfam09383
1185652015809	Predicted flavoprotein [General function prediction only]; Region: COG0431
1185652015810	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1185652015811	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
1185652015812	beta-galactosidase; Region: BGL; TIGR03356
1185652015813	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652015814	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652015815	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1185652015816	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1185652015817	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1185652015818	xylose isomerase; Provisional; Region: PRK05474
1185652015819	xylose isomerase; Region: xylose_isom_A; TIGR02630
1185652015820	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
1185652015821	N- and C-terminal domain interface [polypeptide binding]; other site
1185652015822	D-xylulose kinase; Region: XylB; TIGR01312
1185652015823	active site
1185652015824	MgATP binding site [chemical binding]; other site
1185652015825	catalytic site [active]
1185652015826	metal binding site [ion binding]; metal-binding site
1185652015827	xylulose binding site [chemical binding]; other site
1185652015828	homodimer interface [polypeptide binding]; other site
1185652015829	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1185652015830	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652015831	DNA binding site [nucleotide binding]
1185652015832	domain linker motif; other site
1185652015833	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
1185652015834	putative ligand binding site [chemical binding]; other site
1185652015835	Cytolysin, a secreted calcineurin-like phosphatase [Cell motility and secretion]; Region: COG5555
1185652015836	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1185652015837	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1185652015838	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1185652015839	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652015840	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1185652015841	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652015842	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
1185652015843	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652015844	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1185652015845	active site
1185652015846	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652015847	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1185652015848	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652015849	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1185652015850	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1185652015851	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1185652015852	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1185652015853	HIGH motif; other site
1185652015854	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1185652015855	active site
1185652015856	KMSKS motif; other site
1185652015857	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1185652015858	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1185652015859	dimer interface [polypeptide binding]; other site
1185652015860	putative anticodon binding site; other site
1185652015861	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1185652015862	motif 1; other site
1185652015863	active site
1185652015864	motif 2; other site
1185652015865	motif 3; other site
1185652015866	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1185652015867	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
1185652015868	active site
1185652015869	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
1185652015870	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1185652015871	ATP-dependent DNA ligase; Validated; Region: PRK09247
1185652015872	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
1185652015873	active site
1185652015874	DNA binding site [nucleotide binding]
1185652015875	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
1185652015876	DNA binding site [nucleotide binding]
1185652015877	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3452
1185652015878	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652015879	PAS fold; Region: PAS_3; pfam08447
1185652015880	putative active site [active]
1185652015881	heme pocket [chemical binding]; other site
1185652015882	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652015883	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652015884	metal binding site [ion binding]; metal-binding site
1185652015885	active site
1185652015886	I-site; other site
1185652015887	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1185652015888	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
1185652015889	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1185652015890	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1185652015891	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1185652015892	monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943
1185652015893	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
1185652015894	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
1185652015895	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1185652015896	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
1185652015897	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
1185652015898	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671
1185652015899	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1185652015900	active site
1185652015901	SAM binding site [chemical binding]; other site
1185652015902	homodimer interface [polypeptide binding]; other site
1185652015903	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1185652015904	active site
1185652015905	putative homodimer interface [polypeptide binding]; other site
1185652015906	SAM binding site [chemical binding]; other site
1185652015907	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1185652015908	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
1185652015909	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
1185652015910	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
1185652015911	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1185652015912	active site
1185652015913	SAM binding site [chemical binding]; other site
1185652015914	homodimer interface [polypeptide binding]; other site
1185652015915	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1185652015916	active site
1185652015917	SAM binding site [chemical binding]; other site
1185652015918	homodimer interface [polypeptide binding]; other site
1185652015919	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
1185652015920	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1185652015921	precorrin-3B synthase; Region: CobG; TIGR02435
1185652015922	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
1185652015923	active site
1185652015924	SAM binding site [chemical binding]; other site
1185652015925	homodimer interface [polypeptide binding]; other site
1185652015926	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1185652015927	ligand binding site [chemical binding]; other site
1185652015928	active site
1185652015929	UGI interface [polypeptide binding]; other site
1185652015930	catalytic site [active]
1185652015931	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
1185652015932	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1185652015933	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1185652015934	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652015935	dimer interface [polypeptide binding]; other site
1185652015936	conserved gate region; other site
1185652015937	putative PBP binding loops; other site
1185652015938	ABC-ATPase subunit interface; other site
1185652015939	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
1185652015940	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652015941	Walker A/P-loop; other site
1185652015942	ATP binding site [chemical binding]; other site
1185652015943	Q-loop/lid; other site
1185652015944	ABC transporter signature motif; other site
1185652015945	Walker B; other site
1185652015946	D-loop; other site
1185652015947	H-loop/switch region; other site
1185652015948	TOBE domain; Region: TOBE; pfam03459
1185652015949	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
1185652015950	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1185652015951	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
1185652015952	NAD binding site [chemical binding]; other site
1185652015953	homotetramer interface [polypeptide binding]; other site
1185652015954	homodimer interface [polypeptide binding]; other site
1185652015955	active site
1185652015956	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
1185652015957	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1185652015958	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1185652015959	tetramer interface [polypeptide binding]; other site
1185652015960	TPP-binding site [chemical binding]; other site
1185652015961	heterodimer interface [polypeptide binding]; other site
1185652015962	phosphorylation loop region [posttranslational modification]
1185652015963	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1185652015964	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1185652015965	alpha subunit interface [polypeptide binding]; other site
1185652015966	TPP binding site [chemical binding]; other site
1185652015967	heterodimer interface [polypeptide binding]; other site
1185652015968	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1185652015969	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1185652015970	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1185652015971	E3 interaction surface; other site
1185652015972	lipoyl attachment site [posttranslational modification]; other site
1185652015973	e3 binding domain; Region: E3_binding; pfam02817
1185652015974	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1185652015975	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
1185652015976	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1185652015977	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652015978	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1185652015979	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
1185652015980	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1185652015981	dimer interface [polypeptide binding]; other site
1185652015982	active site
1185652015983	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
1185652015984	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1185652015985	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1185652015986	putative active site [active]
1185652015987	putative substrate binding site [chemical binding]; other site
1185652015988	putative cosubstrate binding site; other site
1185652015989	catalytic site [active]
1185652015990	maleylacetoacetate isomerase; Region: maiA; TIGR01262
1185652015991	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
1185652015992	C-terminal domain interface [polypeptide binding]; other site
1185652015993	GSH binding site (G-site) [chemical binding]; other site
1185652015994	putative dimer interface [polypeptide binding]; other site
1185652015995	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
1185652015996	dimer interface [polypeptide binding]; other site
1185652015997	N-terminal domain interface [polypeptide binding]; other site
1185652015998	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
1185652015999	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1185652016000	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1185652016001	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
1185652016002	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1185652016003	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1185652016004	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652016005	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652016006	putative DNA binding site [nucleotide binding]; other site
1185652016007	putative Zn2+ binding site [ion binding]; other site
1185652016008	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652016009	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
1185652016010	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1185652016011	dimer interface [polypeptide binding]; other site
1185652016012	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1185652016013	active site
1185652016014	Fe binding site [ion binding]; other site
1185652016015	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1185652016016	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652016017	DNA binding residues [nucleotide binding]
1185652016018	dimerization interface [polypeptide binding]; other site
1185652016019	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
1185652016020	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
1185652016021	Walker A/P-loop; other site
1185652016022	ATP binding site [chemical binding]; other site
1185652016023	Q-loop/lid; other site
1185652016024	ABC transporter signature motif; other site
1185652016025	Walker B; other site
1185652016026	D-loop; other site
1185652016027	H-loop/switch region; other site
1185652016028	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1185652016029	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652016030	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652016031	binding surface
1185652016032	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1185652016033	TPR motif; other site
1185652016034	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1185652016035	Methyltransferase domain; Region: Methyltransf_25; pfam13649
1185652016036	cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104
1185652016037	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1185652016038	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1185652016039	metal binding site [ion binding]; metal-binding site
1185652016040	active site
1185652016041	I-site; other site
1185652016042	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1185652016043	glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417
1185652016044	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1185652016045	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1185652016046	substrate binding site [chemical binding]; other site
1185652016047	catalytic Zn binding site [ion binding]; other site
1185652016048	NAD binding site [chemical binding]; other site
1185652016049	structural Zn binding site [ion binding]; other site
1185652016050	dimer interface [polypeptide binding]; other site
1185652016051	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
1185652016052	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652016053	substrate binding pocket [chemical binding]; other site
1185652016054	membrane-bound complex binding site; other site
1185652016055	hinge residues; other site
1185652016056	c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874
1185652016057	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
1185652016058	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
1185652016059	Trp docking motif [polypeptide binding]; other site
1185652016060	dimer interface [polypeptide binding]; other site
1185652016061	active site
1185652016062	small subunit binding site [polypeptide binding]; other site
1185652016063	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1185652016064	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652016065	Walker A/P-loop; other site
1185652016066	ATP binding site [chemical binding]; other site
1185652016067	Q-loop/lid; other site
1185652016068	ABC transporter signature motif; other site
1185652016069	Walker B; other site
1185652016070	D-loop; other site
1185652016071	H-loop/switch region; other site
1185652016072	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1185652016073	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652016074	dimer interface [polypeptide binding]; other site
1185652016075	conserved gate region; other site
1185652016076	putative PBP binding loops; other site
1185652016077	ABC-ATPase subunit interface; other site
1185652016078	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1185652016079	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652016080	Predicted periplasmic protein [Function unknown]; Region: COG3904
1185652016081	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1185652016082	benzoate transport; Region: 2A0115; TIGR00895
1185652016083	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652016084	putative substrate translocation pore; other site
1185652016085	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652016086	putative substrate translocation pore; other site
1185652016087	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
1185652016088	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652016089	NAD(P) binding site [chemical binding]; other site
1185652016090	active site
1185652016091	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
1185652016092	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1185652016093	catalytic loop [active]
1185652016094	iron binding site [ion binding]; other site
1185652016095	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
1185652016096	FAD binding pocket [chemical binding]; other site
1185652016097	FAD binding motif [chemical binding]; other site
1185652016098	phosphate binding motif [ion binding]; other site
1185652016099	beta-alpha-beta structure motif; other site
1185652016100	NAD binding pocket [chemical binding]; other site
1185652016101	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
1185652016102	inter-subunit interface; other site
1185652016103	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
1185652016104	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
1185652016105	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
1185652016106	putative alpha subunit interface [polypeptide binding]; other site
1185652016107	putative active site [active]
1185652016108	putative substrate binding site [chemical binding]; other site
1185652016109	Fe binding site [ion binding]; other site
1185652016110	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
1185652016111	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
1185652016112	dimer interface [polypeptide binding]; other site
1185652016113	active site
1185652016114	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
1185652016115	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
1185652016116	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1185652016117	metal binding site [ion binding]; metal-binding site
1185652016118	substrate binding pocket [chemical binding]; other site
1185652016119	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1185652016120	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652016121	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652016122	dimerization interface [polypeptide binding]; other site
1185652016123	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652016124	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652016125	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1185652016126	dimerization interface [polypeptide binding]; other site
1185652016127	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1185652016128	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
1185652016129	putative ligand binding site [chemical binding]; other site
1185652016130	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1185652016131	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1185652016132	Walker A/P-loop; other site
1185652016133	ATP binding site [chemical binding]; other site
1185652016134	Q-loop/lid; other site
1185652016135	ABC transporter signature motif; other site
1185652016136	Walker B; other site
1185652016137	D-loop; other site
1185652016138	H-loop/switch region; other site
1185652016139	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1185652016140	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1185652016141	Walker A/P-loop; other site
1185652016142	ATP binding site [chemical binding]; other site
1185652016143	Q-loop/lid; other site
1185652016144	ABC transporter signature motif; other site
1185652016145	Walker B; other site
1185652016146	D-loop; other site
1185652016147	H-loop/switch region; other site
1185652016148	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1185652016149	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652016150	TM-ABC transporter signature motif; other site
1185652016151	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1185652016152	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1185652016153	TM-ABC transporter signature motif; other site
1185652016154	choline dehydrogenase; Validated; Region: PRK02106
1185652016155	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1185652016156	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
1185652016157	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1185652016158	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1185652016159	substrate binding pocket [chemical binding]; other site
1185652016160	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1185652016161	B12 binding site [chemical binding]; other site
1185652016162	cobalt ligand [ion binding]; other site
1185652016163	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1185652016164	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
1185652016165	dimerization interface [polypeptide binding]; other site
1185652016166	putative active cleft [active]
1185652016167	hypothetical protein; Provisional; Region: PRK02487
1185652016168	fructokinase; Reviewed; Region: PRK09557
1185652016169	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1185652016170	Predicted transcriptional regulator [Transcription]; Region: COG2932
1185652016171	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
1185652016172	Phage Terminase; Region: Terminase_1; pfam03354
1185652016173	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1185652016174	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1185652016175	catalytic residues [active]
1185652016176	catalytic nucleophile [active]
1185652016177	Presynaptic Site I dimer interface [polypeptide binding]; other site
1185652016178	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1185652016179	Synaptic Flat tetramer interface [polypeptide binding]; other site
1185652016180	Synaptic Site I dimer interface [polypeptide binding]; other site
1185652016181	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1185652016182	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1185652016183	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1185652016184	active site
1185652016185	DNA binding site [nucleotide binding]
1185652016186	Int/Topo IB signature motif; other site
1185652016187	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
1185652016188	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1185652016189	active site
1185652016190	metal binding site [ion binding]; metal-binding site
1185652016191	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1185652016192	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1185652016193	NAD binding site [chemical binding]; other site
1185652016194	catalytic Zn binding site [ion binding]; other site
1185652016195	structural Zn binding site [ion binding]; other site
1185652016196	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
1185652016197	short chain dehydrogenase; Provisional; Region: PRK08267
1185652016198	putative NAD(P) binding site [chemical binding]; other site
1185652016199	active site
1185652016200	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
1185652016201	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
1185652016202	active site
1185652016203	DNA binding site [nucleotide binding]
1185652016204	Int/Topo IB signature motif; other site
1185652016205	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
1185652016206	BON domain; Region: BON; pfam04972
1185652016207	short chain dehydrogenase; Provisional; Region: PRK06701
1185652016208	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1185652016209	NAD binding site [chemical binding]; other site
1185652016210	metal binding site [ion binding]; metal-binding site
1185652016211	active site
1185652016212	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
1185652016213	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652016214	S-adenosylmethionine binding site [chemical binding]; other site
1185652016215	Erythromycin esterase; Region: Erythro_esteras; pfam05139
1185652016216	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1185652016217	dinuclear metal binding motif [ion binding]; other site
1185652016218	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
1185652016219	META domain; Region: META; cl01245
1185652016220	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1185652016221	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1185652016222	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1185652016223	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1185652016224	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1185652016225	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1185652016226	substrate-cofactor binding pocket; other site
1185652016227	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652016228	catalytic residue [active]
1185652016229	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1185652016230	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
1185652016231	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1185652016232	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1185652016233	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1185652016234	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1185652016235	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1185652016236	BA14K-like protein; Region: BA14K; pfam07886
1185652016237	Uncharacterized conserved protein [Function unknown]; Region: COG5649
1185652016238	Uncharacterized conserved protein [Function unknown]; Region: COG5649
1185652016239	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652016240	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652016241	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1185652016242	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1185652016243	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1185652016244	active site
1185652016245	catalytic tetrad [active]
1185652016246	Cupin domain; Region: Cupin_2; pfam07883
1185652016247	Helix-turn-helix domain; Region: HTH_18; pfam12833
1185652016248	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652016249	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
1185652016250	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1185652016251	dimer interface [polypeptide binding]; other site
1185652016252	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
1185652016253	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1185652016254	Surface antigen; Region: Bac_surface_Ag; pfam01103
1185652016255	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
1185652016256	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
1185652016257	Family of unknown function (DUF490); Region: DUF490; pfam04357
1185652016258	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
1185652016259	putative dimer interface [polypeptide binding]; other site
1185652016260	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652016261	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652016262	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1185652016263	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652016264	Arginase family; Region: Arginase; cd09989
1185652016265	active site
1185652016266	Mn binding site [ion binding]; other site
1185652016267	oligomer interface [polypeptide binding]; other site
1185652016268	ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854
1185652016269	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1185652016270	inhibitor-cofactor binding pocket; inhibition site
1185652016271	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652016272	catalytic residue [active]
1185652016273	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1185652016274	putative CheA interaction surface; other site
1185652016275	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
1185652016276	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1185652016277	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1185652016278	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1185652016279	catalytic loop [active]
1185652016280	iron binding site [ion binding]; other site
1185652016281	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1185652016282	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1185652016283	[4Fe-4S] binding site [ion binding]; other site
1185652016284	molybdopterin cofactor binding site; other site
1185652016285	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
1185652016286	molybdopterin cofactor binding site; other site
1185652016287	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
1185652016288	putative dimer interface [polypeptide binding]; other site
1185652016289	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
1185652016290	SLBB domain; Region: SLBB; pfam10531
1185652016291	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
1185652016292	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
1185652016293	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
1185652016294	putative dimer interface [polypeptide binding]; other site
1185652016295	[2Fe-2S] cluster binding site [ion binding]; other site
1185652016296	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652016297	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652016298	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1185652016299	dimerization interface [polypeptide binding]; other site
1185652016300	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1185652016301	classical (c) SDRs; Region: SDR_c; cd05233
1185652016302	NAD(P) binding site [chemical binding]; other site
1185652016303	active site
1185652016304	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1185652016305	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1185652016306	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1185652016307	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
1185652016308	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1185652016309	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1185652016310	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1185652016311	Walker A/P-loop; other site
1185652016312	ATP binding site [chemical binding]; other site
1185652016313	Q-loop/lid; other site
1185652016314	ABC transporter signature motif; other site
1185652016315	Walker B; other site
1185652016316	D-loop; other site
1185652016317	H-loop/switch region; other site
1185652016318	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1185652016319	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1185652016320	Walker A/P-loop; other site
1185652016321	ATP binding site [chemical binding]; other site
1185652016322	Q-loop/lid; other site
1185652016323	ABC transporter signature motif; other site
1185652016324	Walker B; other site
1185652016325	D-loop; other site
1185652016326	H-loop/switch region; other site
1185652016327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652016328	dimer interface [polypeptide binding]; other site
1185652016329	conserved gate region; other site
1185652016330	putative PBP binding loops; other site
1185652016331	ABC-ATPase subunit interface; other site
1185652016332	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652016333	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652016334	dimer interface [polypeptide binding]; other site
1185652016335	conserved gate region; other site
1185652016336	ABC-ATPase subunit interface; other site
1185652016337	Predicted small integral membrane protein [Function unknown]; Region: COG5477
1185652016338	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652016339	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
1185652016340	EamA-like transporter family; Region: EamA; pfam00892
1185652016341	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1185652016342	metal binding site 2 [ion binding]; metal-binding site
1185652016343	putative DNA binding helix; other site
1185652016344	metal binding site 1 [ion binding]; metal-binding site
1185652016345	dimer interface [polypeptide binding]; other site
1185652016346	structural Zn2+ binding site [ion binding]; other site
1185652016347	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1185652016348	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1185652016349	metal binding site [ion binding]; metal-binding site
1185652016350	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
1185652016351	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1185652016352	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1185652016353	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1185652016354	ABC-ATPase subunit  interface; other site
1185652016355	dimer interface [polypeptide binding]; other site
1185652016356	putative PBP binding regions; other site
1185652016357	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1185652016358	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1185652016359	ABC-ATPase subunit  interface; other site
1185652016360	dimer interface [polypeptide binding]; other site
1185652016361	putative PBP binding regions; other site
1185652016362	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652016363	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1185652016364	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652016365	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
1185652016366	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652016367	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1185652016368	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1185652016369	gamma subunit interface [polypeptide binding]; other site
1185652016370	epsilon subunit interface [polypeptide binding]; other site
1185652016371	LBP interface [polypeptide binding]; other site
1185652016372	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1185652016373	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1185652016374	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1185652016375	alpha subunit interaction interface [polypeptide binding]; other site
1185652016376	Walker A motif; other site
1185652016377	ATP binding site [chemical binding]; other site
1185652016378	Walker B motif; other site
1185652016379	inhibitor binding site; inhibition site
1185652016380	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1185652016381	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1185652016382	core domain interface [polypeptide binding]; other site
1185652016383	delta subunit interface [polypeptide binding]; other site
1185652016384	epsilon subunit interface [polypeptide binding]; other site
1185652016385	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1185652016386	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1185652016387	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1185652016388	beta subunit interaction interface [polypeptide binding]; other site
1185652016389	Walker A motif; other site
1185652016390	ATP binding site [chemical binding]; other site
1185652016391	Walker B motif; other site
1185652016392	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1185652016393	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1185652016394	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1185652016395	primosome assembly protein PriA; Validated; Region: PRK05580
1185652016396	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1185652016397	ATP binding site [chemical binding]; other site
1185652016398	putative Mg++ binding site [ion binding]; other site
1185652016399	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1185652016400	nucleotide binding region [chemical binding]; other site
1185652016401	ATP-binding site [chemical binding]; other site
1185652016402	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1185652016403	active site
1185652016404	intersubunit interactions; other site
1185652016405	catalytic residue [active]
1185652016406	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652016407	Walker A/P-loop; other site
1185652016408	ATP binding site [chemical binding]; other site
1185652016409	Putative hemolysin [General function prediction only]; Region: COG3176
1185652016410	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1185652016411	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1185652016412	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1185652016413	active site
1185652016414	DNA binding site [nucleotide binding]
1185652016415	Int/Topo IB signature motif; other site
1185652016416	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
1185652016417	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
1185652016418	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
1185652016419	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1185652016420	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1185652016421	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1185652016422	short chain dehydrogenase; Provisional; Region: PRK06123
1185652016423	classical (c) SDRs; Region: SDR_c; cd05233
1185652016424	NAD(P) binding site [chemical binding]; other site
1185652016425	active site
1185652016426	LysE type translocator; Region: LysE; cl00565
1185652016427	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1185652016428	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1185652016429	E3 interaction surface; other site
1185652016430	lipoyl attachment site [posttranslational modification]; other site
1185652016431	e3 binding domain; Region: E3_binding; pfam02817
1185652016432	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1185652016433	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1185652016434	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1185652016435	TPP-binding site [chemical binding]; other site
1185652016436	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1185652016437	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1185652016438	CoA binding domain; Region: CoA_binding; smart00881
1185652016439	CoA-ligase; Region: Ligase_CoA; pfam00549
1185652016440	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1185652016441	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1185652016442	CoA-ligase; Region: Ligase_CoA; pfam00549
1185652016443	malate dehydrogenase; Reviewed; Region: PRK06223
1185652016444	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
1185652016445	NAD(P) binding site [chemical binding]; other site
1185652016446	dimer interface [polypeptide binding]; other site
1185652016447	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1185652016448	substrate binding site [chemical binding]; other site
1185652016449	Predicted ATPase [General function prediction only]; Region: COG1485
1185652016450	Protease inhibitor Inh; Region: Inh; pfam02974
1185652016451	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
1185652016452	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1185652016453	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1185652016454	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
1185652016455	L-aspartate oxidase; Provisional; Region: PRK06175
1185652016456	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1185652016457	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
1185652016458	putative SdhC subunit interface [polypeptide binding]; other site
1185652016459	putative proximal heme binding site [chemical binding]; other site
1185652016460	putative Iron-sulfur protein interface [polypeptide binding]; other site
1185652016461	putative proximal quinone binding site; other site
1185652016462	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
1185652016463	Iron-sulfur protein interface; other site
1185652016464	proximal quinone binding site [chemical binding]; other site
1185652016465	SdhD (CybS) interface [polypeptide binding]; other site
1185652016466	proximal heme binding site [chemical binding]; other site
1185652016467	Predicted methyltransferase [General function prediction only]; Region: COG3897
1185652016468	Uncharacterized conserved protein [Function unknown]; Region: COG2947
1185652016469	YciI-like protein; Reviewed; Region: PRK12865
1185652016470	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1185652016471	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1185652016472	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1185652016473	UGMP family protein; Validated; Region: PRK09604
1185652016474	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1185652016475	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1185652016476	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1185652016477	domain interfaces; other site
1185652016478	active site
1185652016479	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1185652016480	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1185652016481	active site
1185652016482	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
1185652016483	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
1185652016484	HemY protein N-terminus; Region: HemY_N; pfam07219
1185652016485	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
1185652016486	putative metal binding site [ion binding]; other site
1185652016487	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1185652016488	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1185652016489	catalytic triad [active]
1185652016490	enterobactin exporter EntS; Provisional; Region: PRK10489
1185652016491	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652016492	putative substrate translocation pore; other site
1185652016493	Predicted integral membrane protein [Function unknown]; Region: COG0762
1185652016494	hypothetical protein; Validated; Region: PRK01310
1185652016495	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1185652016496	dimer interface [polypeptide binding]; other site
1185652016497	substrate binding site [chemical binding]; other site
1185652016498	metal binding sites [ion binding]; metal-binding site
1185652016499	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1185652016500	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652016501	Coenzyme A binding pocket [chemical binding]; other site
1185652016502	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1185652016503	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1185652016504	G1 box; other site
1185652016505	putative GEF interaction site [polypeptide binding]; other site
1185652016506	GTP/Mg2+ binding site [chemical binding]; other site
1185652016507	Switch I region; other site
1185652016508	G2 box; other site
1185652016509	G3 box; other site
1185652016510	Switch II region; other site
1185652016511	G4 box; other site
1185652016512	G5 box; other site
1185652016513	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1185652016514	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1185652016515	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
1185652016516	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1185652016517	putative active site [active]
1185652016518	putative metal binding site [ion binding]; other site
1185652016519	amidase; Provisional; Region: PRK07056
1185652016520	amidase; Validated; Region: PRK05962
1185652016521	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652016522	cyclase homology domain; Region: CHD; cd07302
1185652016523	nucleotidyl binding site; other site
1185652016524	metal binding site [ion binding]; metal-binding site
1185652016525	dimer interface [polypeptide binding]; other site
1185652016526	Predicted integral membrane protein [Function unknown]; Region: COG5616
1185652016527	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652016528	TPR motif; other site
1185652016529	binding surface
1185652016530	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1185652016531	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
1185652016532	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1185652016533	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1185652016534	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1185652016535	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652016536	dimer interface [polypeptide binding]; other site
1185652016537	conserved gate region; other site
1185652016538	putative PBP binding loops; other site
1185652016539	ABC-ATPase subunit interface; other site
1185652016540	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1185652016541	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652016542	Walker A/P-loop; other site
1185652016543	ATP binding site [chemical binding]; other site
1185652016544	Q-loop/lid; other site
1185652016545	ABC transporter signature motif; other site
1185652016546	Walker B; other site
1185652016547	D-loop; other site
1185652016548	H-loop/switch region; other site
1185652016549	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652016550	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652016551	Walker A/P-loop; other site
1185652016552	ATP binding site [chemical binding]; other site
1185652016553	Q-loop/lid; other site
1185652016554	ABC transporter signature motif; other site
1185652016555	Walker B; other site
1185652016556	D-loop; other site
1185652016557	H-loop/switch region; other site
1185652016558	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
1185652016559	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1185652016560	Predicted integral membrane protein [Function unknown]; Region: COG0392
1185652016561	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1185652016562	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1185652016563	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1185652016564	Protein export membrane protein; Region: SecD_SecF; cl14618
1185652016565	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1185652016566	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1185652016567	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1185652016568	protein binding site [polypeptide binding]; other site
1185652016569	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1185652016570	Response regulator receiver domain; Region: Response_reg; pfam00072
1185652016571	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652016572	active site
1185652016573	phosphorylation site [posttranslational modification]
1185652016574	intermolecular recognition site; other site
1185652016575	dimerization interface [polypeptide binding]; other site
1185652016576	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1185652016577	Histidine kinase; Region: HisKA_2; pfam07568
1185652016578	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652016579	ATP binding site [chemical binding]; other site
1185652016580	Mg2+ binding site [ion binding]; other site
1185652016581	G-X-G motif; other site
1185652016582	Response regulator receiver domain; Region: Response_reg; pfam00072
1185652016583	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652016584	active site
1185652016585	phosphorylation site [posttranslational modification]
1185652016586	intermolecular recognition site; other site
1185652016587	dimerization interface [polypeptide binding]; other site
1185652016588	CHASE3 domain; Region: CHASE3; cl05000
1185652016589	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652016590	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652016591	dimer interface [polypeptide binding]; other site
1185652016592	phosphorylation site [posttranslational modification]
1185652016593	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652016594	ATP binding site [chemical binding]; other site
1185652016595	Mg2+ binding site [ion binding]; other site
1185652016596	G-X-G motif; other site
1185652016597	putative sialic acid transporter; Region: 2A0112; TIGR00891
1185652016598	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652016599	putative substrate translocation pore; other site
1185652016600	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1185652016601	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652016602	active site
1185652016603	phosphorylation site [posttranslational modification]
1185652016604	intermolecular recognition site; other site
1185652016605	dimerization interface [polypeptide binding]; other site
1185652016606	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652016607	Walker A motif; other site
1185652016608	ATP binding site [chemical binding]; other site
1185652016609	Walker B motif; other site
1185652016610	arginine finger; other site
1185652016611	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1185652016612	Protein of unknown function (DUF1614); Region: DUF1614; pfam07758
1185652016613	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
1185652016614	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652016615	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652016616	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1185652016617	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1185652016618	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1185652016619	trimer interface [polypeptide binding]; other site
1185652016620	active site
1185652016621	dimer interface [polypeptide binding]; other site
1185652016622	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268
1185652016623	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
1185652016624	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1185652016625	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1185652016626	shikimate binding site; other site
1185652016627	NAD(P) binding site [chemical binding]; other site
1185652016628	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1185652016629	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1185652016630	Walker A/P-loop; other site
1185652016631	ATP binding site [chemical binding]; other site
1185652016632	Q-loop/lid; other site
1185652016633	ABC transporter signature motif; other site
1185652016634	Walker B; other site
1185652016635	D-loop; other site
1185652016636	H-loop/switch region; other site
1185652016637	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1185652016638	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652016639	substrate binding pocket [chemical binding]; other site
1185652016640	membrane-bound complex binding site; other site
1185652016641	hinge residues; other site
1185652016642	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652016643	dimer interface [polypeptide binding]; other site
1185652016644	conserved gate region; other site
1185652016645	putative PBP binding loops; other site
1185652016646	ABC-ATPase subunit interface; other site
1185652016647	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652016648	dimer interface [polypeptide binding]; other site
1185652016649	conserved gate region; other site
1185652016650	putative PBP binding loops; other site
1185652016651	ABC-ATPase subunit interface; other site
1185652016652	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1185652016653	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1185652016654	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652016655	DNA-binding site [nucleotide binding]; DNA binding site
1185652016656	FCD domain; Region: FCD; pfam07729
1185652016657	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
1185652016658	chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465
1185652016659	active site
1185652016660	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1185652016661	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1185652016662	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652016663	substrate binding pocket [chemical binding]; other site
1185652016664	membrane-bound complex binding site; other site
1185652016665	hinge residues; other site
1185652016666	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1185652016667	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
1185652016668	putative N- and C-terminal domain interface [polypeptide binding]; other site
1185652016669	putative active site [active]
1185652016670	MgATP binding site [chemical binding]; other site
1185652016671	catalytic site [active]
1185652016672	metal binding site [ion binding]; metal-binding site
1185652016673	putative xylulose binding site [chemical binding]; other site
1185652016674	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
1185652016675	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
1185652016676	putative active site; other site
1185652016677	catalytic residue [active]
1185652016678	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1185652016679	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1185652016680	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1185652016681	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1185652016682	active site
1185652016683	catalytic tetrad [active]
1185652016684	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1185652016685	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1185652016686	DNA binding residues [nucleotide binding]
1185652016687	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1185652016688	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652016689	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652016690	TM-ABC transporter signature motif; other site
1185652016691	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1185652016692	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652016693	Walker A/P-loop; other site
1185652016694	ATP binding site [chemical binding]; other site
1185652016695	Q-loop/lid; other site
1185652016696	Walker B; other site
1185652016697	D-loop; other site
1185652016698	H-loop/switch region; other site
1185652016699	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652016700	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1185652016701	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1185652016702	ligand binding site [chemical binding]; other site
1185652016703	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1185652016704	DNA binding site [nucleotide binding]
1185652016705	active site
1185652016706	Int/Topo IB signature motif; other site
1185652016707	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
1185652016708	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1185652016709	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1185652016710	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652016711	motif II; other site
1185652016712	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
1185652016713	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
1185652016714	Cytochrome c; Region: Cytochrom_C; pfam00034
1185652016715	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1185652016716	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
1185652016717	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
1185652016718	Low-spin heme binding site [chemical binding]; other site
1185652016719	D-pathway; other site
1185652016720	Putative water exit pathway; other site
1185652016721	Binuclear center (active site) [active]
1185652016722	K-pathway; other site
1185652016723	Putative proton exit pathway; other site
1185652016724	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1185652016725	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1185652016726	ring oligomerisation interface [polypeptide binding]; other site
1185652016727	ATP/Mg binding site [chemical binding]; other site
1185652016728	stacking interactions; other site
1185652016729	hinge regions; other site
1185652016730	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1185652016731	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1185652016732	substrate-cofactor binding pocket; other site
1185652016733	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652016734	catalytic residue [active]
1185652016735	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1185652016736	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1185652016737	Cu(I) binding site [ion binding]; other site
1185652016738	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1185652016739	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1185652016740	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1185652016741	active site
1185652016742	metal binding site [ion binding]; metal-binding site
1185652016743	Cytochrome c [Energy production and conversion]; Region: COG3258
1185652016744	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1185652016745	HTH-like domain; Region: HTH_21; pfam13276
1185652016746	Integrase core domain; Region: rve; pfam00665
1185652016747	Integrase core domain; Region: rve_3; pfam13683
1185652016748	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1185652016749	DNA-binding interface [nucleotide binding]; DNA binding site
1185652016750	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1185652016751	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
1185652016752	Cytochrome c; Region: Cytochrom_C; cl11414
1185652016753	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
1185652016754	sulfur oxidation protein SoxY; Provisional; Region: PRK07474
1185652016755	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
1185652016756	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1185652016757	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1185652016758	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1185652016759	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1185652016760	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1185652016761	GTPase CgtA; Reviewed; Region: obgE; PRK12299
1185652016762	GTP1/OBG; Region: GTP1_OBG; pfam01018
1185652016763	Obg GTPase; Region: Obg; cd01898
1185652016764	G1 box; other site
1185652016765	GTP/Mg2+ binding site [chemical binding]; other site
1185652016766	Switch I region; other site
1185652016767	G2 box; other site
1185652016768	G3 box; other site
1185652016769	Switch II region; other site
1185652016770	G4 box; other site
1185652016771	G5 box; other site
1185652016772	gamma-glutamyl kinase; Provisional; Region: PRK05429
1185652016773	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1185652016774	nucleotide binding site [chemical binding]; other site
1185652016775	homotetrameric interface [polypeptide binding]; other site
1185652016776	putative phosphate binding site [ion binding]; other site
1185652016777	putative allosteric binding site; other site
1185652016778	PUA domain; Region: PUA; pfam01472
1185652016779	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1185652016780	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1185652016781	putative catalytic cysteine [active]
1185652016782	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1185652016783	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1185652016784	active site
1185652016785	(T/H)XGH motif; other site
1185652016786	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1185652016787	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1185652016788	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
1185652016789	Peptidase family M23; Region: Peptidase_M23; pfam01551
1185652016790	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1185652016791	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1185652016792	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1185652016793	protein binding site [polypeptide binding]; other site
1185652016794	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1185652016795	Catalytic dyad [active]
1185652016796	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
1185652016797	NodB motif; other site
1185652016798	putative active site [active]
1185652016799	putative catalytic site [active]
1185652016800	Zn binding site [ion binding]; other site
1185652016801	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
1185652016802	putative active site [active]
1185652016803	Ap4A binding site [chemical binding]; other site
1185652016804	nudix motif; other site
1185652016805	putative metal binding site [ion binding]; other site
1185652016806	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
1185652016807	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1185652016808	heme binding site [chemical binding]; other site
1185652016809	ferroxidase pore; other site
1185652016810	ferroxidase diiron center [ion binding]; other site
1185652016811	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
1185652016812	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
1185652016813	putative active site [active]
1185652016814	putative PHP Thumb interface [polypeptide binding]; other site
1185652016815	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1185652016816	generic binding surface II; other site
1185652016817	generic binding surface I; other site
1185652016818	DNA Polymerase Y-family; Region: PolY_like; cd03468
1185652016819	active site
1185652016820	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
1185652016821	DNA binding site [nucleotide binding]
1185652016822	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
1185652016823	Uncharacterized conserved protein [Function unknown]; Region: COG2835
1185652016824	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
1185652016825	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1185652016826	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1185652016827	catalytic residues [active]
1185652016828	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1185652016829	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
1185652016830	putative deacylase active site [active]
1185652016831	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
1185652016832	Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897
1185652016833	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1185652016834	proposed active site lysine [active]
1185652016835	conserved cys residue [active]
1185652016836	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1185652016837	nudix motif; other site
1185652016838	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1185652016839	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652016840	Walker A motif; other site
1185652016841	ATP binding site [chemical binding]; other site
1185652016842	Walker B motif; other site
1185652016843	arginine finger; other site
1185652016844	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1185652016845	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1185652016846	substrate binding site [chemical binding]; other site
1185652016847	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1185652016848	Uncharacterized conserved small protein [Function unknown]; Region: COG5515
1185652016849	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1185652016850	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1185652016851	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1185652016852	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1185652016853	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1185652016854	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652016855	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652016856	homodimer interface [polypeptide binding]; other site
1185652016857	catalytic residue [active]
1185652016858	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1185652016859	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1185652016860	substrate binding pocket [chemical binding]; other site
1185652016861	chain length determination region; other site
1185652016862	substrate-Mg2+ binding site; other site
1185652016863	catalytic residues [active]
1185652016864	aspartate-rich region 1; other site
1185652016865	active site lid residues [active]
1185652016866	aspartate-rich region 2; other site
1185652016867	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
1185652016868	Transglycosylase; Region: Transgly; cl17702
1185652016869	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
1185652016870	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1185652016871	putative C-terminal domain interface [polypeptide binding]; other site
1185652016872	putative GSH binding site (G-site) [chemical binding]; other site
1185652016873	putative dimer interface [polypeptide binding]; other site
1185652016874	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
1185652016875	putative N-terminal domain interface [polypeptide binding]; other site
1185652016876	putative dimer interface [polypeptide binding]; other site
1185652016877	putative substrate binding pocket (H-site) [chemical binding]; other site
1185652016878	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
1185652016879	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
1185652016880	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
1185652016881	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
1185652016882	putative acyltransferase; Provisional; Region: PRK05790
1185652016883	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1185652016884	dimer interface [polypeptide binding]; other site
1185652016885	active site
1185652016886	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
1185652016887	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1185652016888	NAD(P) binding site [chemical binding]; other site
1185652016889	homotetramer interface [polypeptide binding]; other site
1185652016890	homodimer interface [polypeptide binding]; other site
1185652016891	active site
1185652016892	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1185652016893	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1185652016894	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1185652016895	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
1185652016896	Thiamine pyrophosphokinase; Region: TPK; cd07995
1185652016897	active site
1185652016898	dimerization interface [polypeptide binding]; other site
1185652016899	thiamine binding site [chemical binding]; other site
1185652016900	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
1185652016901	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
1185652016902	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
1185652016903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652016904	dimer interface [polypeptide binding]; other site
1185652016905	conserved gate region; other site
1185652016906	putative PBP binding loops; other site
1185652016907	ABC-ATPase subunit interface; other site
1185652016908	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
1185652016909	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652016910	Walker A/P-loop; other site
1185652016911	ATP binding site [chemical binding]; other site
1185652016912	Q-loop/lid; other site
1185652016913	ABC transporter signature motif; other site
1185652016914	Walker B; other site
1185652016915	D-loop; other site
1185652016916	H-loop/switch region; other site
1185652016917	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
1185652016918	Peptidase family M48; Region: Peptidase_M48; pfam01435
1185652016919	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
1185652016920	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1185652016921	RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500
1185652016922	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1185652016923	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
1185652016924	DNA binding residues [nucleotide binding]
1185652016925	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
1185652016926	Ferredoxin [Energy production and conversion]; Region: COG1146
1185652016927	4Fe-4S binding domain; Region: Fer4; pfam00037
1185652016928	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
1185652016929	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1185652016930	RNA binding surface [nucleotide binding]; other site
1185652016931	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1185652016932	ATP binding site [chemical binding]; other site
1185652016933	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1185652016934	putative Mg++ binding site [ion binding]; other site
1185652016935	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1185652016936	nucleotide binding region [chemical binding]; other site
1185652016937	ATP-binding site [chemical binding]; other site
1185652016938	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1185652016939	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1185652016940	MarR family; Region: MarR_2; pfam12802
1185652016941	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652016942	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1185652016943	putative substrate translocation pore; other site
1185652016944	argininosuccinate synthase; Provisional; Region: PRK13820
1185652016945	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1185652016946	ANP binding site [chemical binding]; other site
1185652016947	Substrate Binding Site II [chemical binding]; other site
1185652016948	Substrate Binding Site I [chemical binding]; other site
1185652016949	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1185652016950	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
1185652016951	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652016952	Walker A/P-loop; other site
1185652016953	ATP binding site [chemical binding]; other site
1185652016954	Q-loop/lid; other site
1185652016955	ABC transporter signature motif; other site
1185652016956	Walker B; other site
1185652016957	D-loop; other site
1185652016958	H-loop/switch region; other site
1185652016959	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652016960	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1185652016961	TM-ABC transporter signature motif; other site
1185652016962	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1185652016963	zinc binding site [ion binding]; other site
1185652016964	putative ligand binding site [chemical binding]; other site
1185652016965	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
1185652016966	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1185652016967	FeS/SAM binding site; other site
1185652016968	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
1185652016969	Uncharacterized conserved protein [Function unknown]; Region: COG3339
1185652016970	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1185652016971	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1185652016972	active site
1185652016973	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
1185652016974	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1185652016975	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1185652016976	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
1185652016977	active site
1185652016978	catalytic triad [active]
1185652016979	oxyanion hole [active]
1185652016980	switch loop; other site
1185652016981	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
1185652016982	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1185652016983	Walker A/P-loop; other site
1185652016984	ATP binding site [chemical binding]; other site
1185652016985	Q-loop/lid; other site
1185652016986	ABC transporter signature motif; other site
1185652016987	Walker B; other site
1185652016988	D-loop; other site
1185652016989	H-loop/switch region; other site
1185652016990	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
1185652016991	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1185652016992	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1185652016993	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1185652016994	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1185652016995	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652016996	Coenzyme A binding pocket [chemical binding]; other site
1185652016997	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
1185652016998	Uncharacterized secreted protein [Function unknown]; Region: COG5429
1185652016999	aconitate hydratase; Validated; Region: PRK09277
1185652017000	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1185652017001	substrate binding site [chemical binding]; other site
1185652017002	ligand binding site [chemical binding]; other site
1185652017003	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1185652017004	substrate binding site [chemical binding]; other site
1185652017005	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
1185652017006	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652017007	Walker A/P-loop; other site
1185652017008	ATP binding site [chemical binding]; other site
1185652017009	Q-loop/lid; other site
1185652017010	ABC transporter signature motif; other site
1185652017011	Walker B; other site
1185652017012	D-loop; other site
1185652017013	H-loop/switch region; other site
1185652017014	heme exporter protein CcmB; Region: ccmB; TIGR01190
1185652017015	heme exporter protein CcmC; Region: ccmC; TIGR01191
1185652017016	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
1185652017017	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1185652017018	catalytic residues [active]
1185652017019	central insert; other site
1185652017020	hypothetical protein; Provisional; Region: PRK00944
1185652017021	intracellular septation protein A; Reviewed; Region: PRK00259
1185652017022	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1185652017023	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1185652017024	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1185652017025	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1185652017026	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1185652017027	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1185652017028	FeS/SAM binding site; other site
1185652017029	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
1185652017030	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1185652017031	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1185652017032	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1185652017033	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1185652017034	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1185652017035	MarR family; Region: MarR_2; pfam12802
1185652017036	signal recognition particle protein; Provisional; Region: PRK10867
1185652017037	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1185652017038	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1185652017039	P loop; other site
1185652017040	GTP binding site [chemical binding]; other site
1185652017041	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1185652017042	chorismate mutase; Provisional; Region: PRK09239
1185652017043	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
1185652017044	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1185652017045	RimM N-terminal domain; Region: RimM; pfam01782
1185652017046	PRC-barrel domain; Region: PRC; pfam05239
1185652017047	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1185652017048	hypothetical protein; Provisional; Region: PRK10621
1185652017049	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1185652017050	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1185652017051	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1185652017052	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652017053	substrate binding pocket [chemical binding]; other site
1185652017054	membrane-bound complex binding site; other site
1185652017055	hinge residues; other site
1185652017056	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652017057	dimer interface [polypeptide binding]; other site
1185652017058	conserved gate region; other site
1185652017059	putative PBP binding loops; other site
1185652017060	ABC-ATPase subunit interface; other site
1185652017061	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1185652017062	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1185652017063	substrate binding site [chemical binding]; other site
1185652017064	ligand binding site [chemical binding]; other site
1185652017065	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1185652017066	catalytic core [active]
1185652017067	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
1185652017068	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652017069	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652017070	active site
1185652017071	phosphorylation site [posttranslational modification]
1185652017072	intermolecular recognition site; other site
1185652017073	dimerization interface [polypeptide binding]; other site
1185652017074	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652017075	DNA binding site [nucleotide binding]
1185652017076	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1185652017077	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1185652017078	ligand binding site [chemical binding]; other site
1185652017079	flexible hinge region; other site
1185652017080	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1185652017081	putative catalytic site [active]
1185652017082	putative phosphate binding site [ion binding]; other site
1185652017083	active site
1185652017084	metal binding site A [ion binding]; metal-binding site
1185652017085	DNA binding site [nucleotide binding]
1185652017086	putative AP binding site [nucleotide binding]; other site
1185652017087	putative metal binding site B [ion binding]; other site
1185652017088	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
1185652017089	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
1185652017090	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1185652017091	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1185652017092	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1185652017093	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1185652017094	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1185652017095	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1185652017096	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1185652017097	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1185652017098	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1185652017099	active site
1185652017100	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1185652017101	catalytic triad [active]
1185652017102	dimer interface [polypeptide binding]; other site
1185652017103	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
1185652017104	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1185652017105	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652017106	putative substrate translocation pore; other site
1185652017107	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1185652017108	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1185652017109	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1185652017110	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1185652017111	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652017112	dimer interface [polypeptide binding]; other site
1185652017113	conserved gate region; other site
1185652017114	putative PBP binding loops; other site
1185652017115	ABC-ATPase subunit interface; other site
1185652017116	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1185652017117	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652017118	Walker A/P-loop; other site
1185652017119	ATP binding site [chemical binding]; other site
1185652017120	Q-loop/lid; other site
1185652017121	ABC transporter signature motif; other site
1185652017122	Walker B; other site
1185652017123	D-loop; other site
1185652017124	H-loop/switch region; other site
1185652017125	pyruvate carboxylase; Reviewed; Region: PRK12999
1185652017126	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1185652017127	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1185652017128	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1185652017129	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1185652017130	active site
1185652017131	catalytic residues [active]
1185652017132	metal binding site [ion binding]; metal-binding site
1185652017133	homodimer binding site [polypeptide binding]; other site
1185652017134	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1185652017135	carboxyltransferase (CT) interaction site; other site
1185652017136	biotinylation site [posttranslational modification]; other site
1185652017137	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1185652017138	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652017139	DNA binding residues [nucleotide binding]
1185652017140	dimerization interface [polypeptide binding]; other site
1185652017141	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1185652017142	glucan exporter ATP-binding protein; Region: chvA; TIGR01192
1185652017143	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1185652017144	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1185652017145	Walker A/P-loop; other site
1185652017146	ATP binding site [chemical binding]; other site
1185652017147	Q-loop/lid; other site
1185652017148	ABC transporter signature motif; other site
1185652017149	Walker B; other site
1185652017150	D-loop; other site
1185652017151	H-loop/switch region; other site
1185652017152	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1185652017153	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
1185652017154	active site
1185652017155	catalytic triad [active]
1185652017156	dimer interface [polypeptide binding]; other site
1185652017157	OpgC protein; Region: OpgC_C; cl17858
1185652017158	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1185652017159	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
1185652017160	Putative glucoamylase; Region: Glycoamylase; pfam10091
1185652017161	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
1185652017162	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
1185652017163	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
1185652017164	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1185652017165	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652017166	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
1185652017167	dimerization interface [polypeptide binding]; other site
1185652017168	substrate binding pocket [chemical binding]; other site
1185652017169	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
1185652017170	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
1185652017171	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1185652017172	FAD binding domain; Region: FAD_binding_4; pfam01565
1185652017173	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
1185652017174	aldehyde dehydrogenase family 7 member; Region: PLN02315
1185652017175	tetrameric interface [polypeptide binding]; other site
1185652017176	NAD binding site [chemical binding]; other site
1185652017177	catalytic residues [active]
1185652017178	aspartate aminotransferase; Provisional; Region: PRK05764
1185652017179	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652017180	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652017181	homodimer interface [polypeptide binding]; other site
1185652017182	catalytic residue [active]
1185652017183	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1185652017184	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652017185	non-specific DNA binding site [nucleotide binding]; other site
1185652017186	salt bridge; other site
1185652017187	sequence-specific DNA binding site [nucleotide binding]; other site
1185652017188	Cupin domain; Region: Cupin_2; pfam07883
1185652017189	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
1185652017190	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1185652017191	inhibitor-cofactor binding pocket; inhibition site
1185652017192	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652017193	catalytic residue [active]
1185652017194	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
1185652017195	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
1185652017196	MOFRL family; Region: MOFRL; pfam05161
1185652017197	choline dehydrogenase; Validated; Region: PRK02106
1185652017198	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1185652017199	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652017200	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1185652017201	NAD(P) binding site [chemical binding]; other site
1185652017202	active site
1185652017203	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1185652017204	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1185652017205	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1185652017206	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652017207	Walker A/P-loop; other site
1185652017208	ATP binding site [chemical binding]; other site
1185652017209	Q-loop/lid; other site
1185652017210	ABC transporter signature motif; other site
1185652017211	Walker B; other site
1185652017212	D-loop; other site
1185652017213	H-loop/switch region; other site
1185652017214	TOBE domain; Region: TOBE_2; pfam08402
1185652017215	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652017216	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652017217	dimer interface [polypeptide binding]; other site
1185652017218	conserved gate region; other site
1185652017219	putative PBP binding loops; other site
1185652017220	ABC-ATPase subunit interface; other site
1185652017221	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1185652017222	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652017223	dimer interface [polypeptide binding]; other site
1185652017224	conserved gate region; other site
1185652017225	putative PBP binding loops; other site
1185652017226	ABC-ATPase subunit interface; other site
1185652017227	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652017228	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1185652017229	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652017230	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652017231	DNA binding site [nucleotide binding]
1185652017232	domain linker motif; other site
1185652017233	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
1185652017234	ligand binding site [chemical binding]; other site
1185652017235	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1185652017236	Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118
1185652017237	NAD(P) binding site [chemical binding]; other site
1185652017238	catalytic residues [active]
1185652017239	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1185652017240	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1185652017241	substrate binding site [chemical binding]; other site
1185652017242	oxyanion hole (OAH) forming residues; other site
1185652017243	trimer interface [polypeptide binding]; other site
1185652017244	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1185652017245	Coenzyme A transferase; Region: CoA_trans; smart00882
1185652017246	Coenzyme A transferase; Region: CoA_trans; cl17247
1185652017247	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652017248	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652017249	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1185652017250	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1185652017251	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1185652017252	DNA binding site [nucleotide binding]
1185652017253	domain linker motif; other site
1185652017254	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
1185652017255	putative dimerization interface [polypeptide binding]; other site
1185652017256	putative ligand binding site [chemical binding]; other site
1185652017257	Protein of unknown function (DUF993); Region: DUF993; pfam06187
1185652017258	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1185652017259	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1185652017260	active site
1185652017261	Zn binding site [ion binding]; other site
1185652017262	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1185652017263	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1185652017264	tartrate dehydrogenase; Region: TTC; TIGR02089
1185652017265	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
1185652017266	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1185652017267	active site
1185652017268	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652017269	putative substrate translocation pore; other site
1185652017270	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1185652017271	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1185652017272	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1185652017273	murein hydrolase B; Provisional; Region: PRK10760; cl17906
1185652017274	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
1185652017275	active site clefts [active]
1185652017276	zinc binding site [ion binding]; other site
1185652017277	dimer interface [polypeptide binding]; other site
1185652017278	pyridoxamine kinase; Validated; Region: PRK05756
1185652017279	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1185652017280	pyridoxal binding site [chemical binding]; other site
1185652017281	dimer interface [polypeptide binding]; other site
1185652017282	ATP binding site [chemical binding]; other site
1185652017283	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
1185652017284	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
1185652017285	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1185652017286	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1185652017287	purine monophosphate binding site [chemical binding]; other site
1185652017288	dimer interface [polypeptide binding]; other site
1185652017289	putative catalytic residues [active]
1185652017290	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1185652017291	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1185652017292	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
1185652017293	NusB family; Region: NusB; pfam01029
1185652017294	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
1185652017295	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652017296	S-adenosylmethionine binding site [chemical binding]; other site
1185652017297	heat shock protein HtpX; Provisional; Region: PRK01345
1185652017298	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
1185652017299	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
1185652017300	acetyl-CoA synthetase; Provisional; Region: PRK00174
1185652017301	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1185652017302	active site
1185652017303	CoA binding site [chemical binding]; other site
1185652017304	acyl-activating enzyme (AAE) consensus motif; other site
1185652017305	AMP binding site [chemical binding]; other site
1185652017306	acetate binding site [chemical binding]; other site
1185652017307	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820
1185652017308	L-ectoine synthase; Reviewed; Region: ectC; PRK13290
1185652017309	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1185652017310	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652017311	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652017312	dimerization interface [polypeptide binding]; other site
1185652017313	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
1185652017314	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1185652017315	acyl-activating enzyme (AAE) consensus motif; other site
1185652017316	AMP binding site [chemical binding]; other site
1185652017317	active site
1185652017318	CoA binding site [chemical binding]; other site
1185652017319	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1185652017320	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1185652017321	catalytic residue [active]
1185652017322	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1185652017323	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1185652017324	HIGH motif; other site
1185652017325	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1185652017326	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1185652017327	active site
1185652017328	KMSKS motif; other site
1185652017329	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1185652017330	tRNA binding surface [nucleotide binding]; other site
1185652017331	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468
1185652017332	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
1185652017333	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1185652017334	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1185652017335	ParB-like nuclease domain; Region: ParBc; pfam02195
1185652017336	KorB domain; Region: KorB; pfam08535
1185652017337	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1185652017338	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1185652017339	P-loop; other site
1185652017340	Magnesium ion binding site [ion binding]; other site
1185652017341	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1185652017342	Magnesium ion binding site [ion binding]; other site
1185652017343	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1185652017344	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1185652017345	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1185652017346	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1185652017347	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1185652017348	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1185652017349	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1185652017350	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1185652017351	G1 box; other site
1185652017352	GTP/Mg2+ binding site [chemical binding]; other site
1185652017353	Switch I region; other site
1185652017354	G2 box; other site
1185652017355	Switch II region; other site
1185652017356	G3 box; other site
1185652017357	G4 box; other site
1185652017358	G5 box; other site
1185652017359	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1185652017360	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1185652017361	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1185652017362	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1185652017363	RNA binding site [nucleotide binding]; other site
1185652017364	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1185652017365	multimer interface [polypeptide binding]; other site
1185652017366	Walker A motif; other site
1185652017367	ATP binding site [chemical binding]; other site
1185652017368	Walker B motif; other site
1185652017369	Predicted membrane protein [Function unknown]; Region: COG1981
1185652017370	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1185652017371	substrate binding site [chemical binding]; other site
1185652017372	active site
1185652017373	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1185652017374	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1185652017375	active site
1185652017376	dimer interface [polypeptide binding]; other site
1185652017377	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1185652017378	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1185652017379	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1185652017380	shikimate binding site; other site
1185652017381	NAD(P) binding site [chemical binding]; other site
1185652017382	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1185652017383	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1185652017384	CoA-binding site [chemical binding]; other site
1185652017385	ATP-binding [chemical binding]; other site
1185652017386	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
1185652017387	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
1185652017388	active site
1185652017389	catalytic site [active]
1185652017390	substrate binding site [chemical binding]; other site
1185652017391	preprotein translocase subunit SecB; Validated; Region: PRK05751
1185652017392	SecA binding site; other site
1185652017393	Preprotein binding site; other site
1185652017394	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
1185652017395	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
1185652017396	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
1185652017397	MltA specific insert domain; Region: MltA; pfam03562
1185652017398	3D domain; Region: 3D; pfam06725
1185652017399	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
1185652017400	Smr domain; Region: Smr; pfam01713
1185652017401	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1185652017402	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652017403	non-specific DNA binding site [nucleotide binding]; other site
1185652017404	salt bridge; other site
1185652017405	sequence-specific DNA binding site [nucleotide binding]; other site
1185652017406	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
1185652017407	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652017408	Mg2+ binding site [ion binding]; other site
1185652017409	G-X-G motif; other site
1185652017410	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1185652017411	anchoring element; other site
1185652017412	dimer interface [polypeptide binding]; other site
1185652017413	ATP binding site [chemical binding]; other site
1185652017414	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1185652017415	active site
1185652017416	putative metal-binding site [ion binding]; other site
1185652017417	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1185652017418	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
1185652017419	putative FMN binding site [chemical binding]; other site
1185652017420	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
1185652017421	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1185652017422	tetramerization interface [polypeptide binding]; other site
1185652017423	NAD(P) binding site [chemical binding]; other site
1185652017424	catalytic residues [active]
1185652017425	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
1185652017426	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1185652017427	DNA-binding site [nucleotide binding]; DNA binding site
1185652017428	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1185652017429	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1185652017430	DNA-binding site [nucleotide binding]; DNA binding site
1185652017431	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1185652017432	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1185652017433	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1185652017434	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1185652017435	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1185652017436	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1185652017437	active site
1185652017438	catalytic tetrad [active]
1185652017439	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
1185652017440	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1185652017441	putative ligand binding site [chemical binding]; other site
1185652017442	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1185652017443	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652017444	Walker A/P-loop; other site
1185652017445	ATP binding site [chemical binding]; other site
1185652017446	Q-loop/lid; other site
1185652017447	ABC transporter signature motif; other site
1185652017448	Walker B; other site
1185652017449	D-loop; other site
1185652017450	H-loop/switch region; other site
1185652017451	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652017452	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652017453	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1185652017454	TM-ABC transporter signature motif; other site
1185652017455	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
1185652017456	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1185652017457	putative NAD(P) binding site [chemical binding]; other site
1185652017458	catalytic Zn binding site [ion binding]; other site
1185652017459	structural Zn binding site [ion binding]; other site
1185652017460	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1185652017461	Amidohydrolase; Region: Amidohydro_2; pfam04909
1185652017462	active site
1185652017463	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
1185652017464	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
1185652017465	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
1185652017466	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
1185652017467	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1185652017468	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1185652017469	active site
1185652017470	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1185652017471	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1185652017472	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652017473	catalytic residue [active]
1185652017474	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1185652017475	substrate binding site [chemical binding]; other site
1185652017476	active site
1185652017477	catalytic residues [active]
1185652017478	heterodimer interface [polypeptide binding]; other site
1185652017479	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1185652017480	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1185652017481	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1185652017482	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1185652017483	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1185652017484	catalytic residues [active]
1185652017485	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
1185652017486	Part of AAA domain; Region: AAA_19; pfam13245
1185652017487	Family description; Region: UvrD_C_2; pfam13538
1185652017488	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1185652017489	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
1185652017490	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
1185652017491	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
1185652017492	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1185652017493	Substrate binding site; other site
1185652017494	metal-binding site
1185652017495	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1185652017496	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
1185652017497	Phosphotransferase enzyme family; Region: APH; pfam01636
1185652017498	PAS fold; Region: PAS_7; pfam12860
1185652017499	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1185652017500	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652017501	dimer interface [polypeptide binding]; other site
1185652017502	phosphorylation site [posttranslational modification]
1185652017503	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652017504	ATP binding site [chemical binding]; other site
1185652017505	Mg2+ binding site [ion binding]; other site
1185652017506	G-X-G motif; other site
1185652017507	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1185652017508	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1185652017509	homotetramer interface [polypeptide binding]; other site
1185652017510	ligand binding site [chemical binding]; other site
1185652017511	catalytic site [active]
1185652017512	NAD binding site [chemical binding]; other site
1185652017513	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1185652017514	dimerization domain swap beta strand [polypeptide binding]; other site
1185652017515	regulatory protein interface [polypeptide binding]; other site
1185652017516	active site
1185652017517	regulatory phosphorylation site [posttranslational modification]; other site
1185652017518	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1185652017519	active pocket/dimerization site; other site
1185652017520	active site
1185652017521	phosphorylation site [posttranslational modification]
1185652017522	Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493
1185652017523	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1185652017524	Hpr binding site; other site
1185652017525	active site
1185652017526	homohexamer subunit interaction site [polypeptide binding]; other site
1185652017527	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
1185652017528	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
1185652017529	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652017530	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1185652017531	dimerization interface [polypeptide binding]; other site
1185652017532	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652017533	dimer interface [polypeptide binding]; other site
1185652017534	phosphorylation site [posttranslational modification]
1185652017535	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652017536	ATP binding site [chemical binding]; other site
1185652017537	Mg2+ binding site [ion binding]; other site
1185652017538	G-X-G motif; other site
1185652017539	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652017540	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652017541	active site
1185652017542	phosphorylation site [posttranslational modification]
1185652017543	intermolecular recognition site; other site
1185652017544	dimerization interface [polypeptide binding]; other site
1185652017545	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652017546	DNA binding site [nucleotide binding]
1185652017547	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1185652017548	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1185652017549	active site
1185652017550	substrate-binding site [chemical binding]; other site
1185652017551	metal-binding site [ion binding]
1185652017552	ATP binding site [chemical binding]; other site
1185652017553	hypothetical protein; Provisional; Region: PRK09256
1185652017554	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1185652017555	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
1185652017556	pantothenate kinase; Provisional; Region: PRK05439
1185652017557	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1185652017558	ATP-binding site [chemical binding]; other site
1185652017559	CoA-binding site [chemical binding]; other site
1185652017560	Mg2+-binding site [ion binding]; other site
1185652017561	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1185652017562	metal binding site [ion binding]; metal-binding site
1185652017563	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1185652017564	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1185652017565	substrate binding site [chemical binding]; other site
1185652017566	glutamase interaction surface [polypeptide binding]; other site
1185652017567	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1185652017568	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1185652017569	catalytic residues [active]
1185652017570	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
1185652017571	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1185652017572	putative active site [active]
1185652017573	oxyanion strand; other site
1185652017574	catalytic triad [active]
1185652017575	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
1185652017576	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1185652017577	putative active site pocket [active]
1185652017578	4-fold oligomerization interface [polypeptide binding]; other site
1185652017579	metal binding residues [ion binding]; metal-binding site
1185652017580	3-fold/trimer interface [polypeptide binding]; other site
1185652017581	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1185652017582	active site
1185652017583	HslU subunit interaction site [polypeptide binding]; other site
1185652017584	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1185652017585	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
1185652017586	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1185652017587	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652017588	Walker A motif; other site
1185652017589	ATP binding site [chemical binding]; other site
1185652017590	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1185652017591	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1185652017592	Protein of unknown function (DUF1402); Region: DUF1402; pfam07182
1185652017593	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1185652017594	Cytochrome P450; Region: p450; cl12078
1185652017595	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1185652017596	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1185652017597	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1185652017598	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
1185652017599	active site
1185652017600	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1185652017601	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1185652017602	Protein of unknown function (DUF1052); Region: DUF1052; pfam06319
1185652017603	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
1185652017604	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652017605	active site
1185652017606	phosphorylation site [posttranslational modification]
1185652017607	intermolecular recognition site; other site
1185652017608	dimerization interface [polypeptide binding]; other site
1185652017609	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652017610	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652017611	dimer interface [polypeptide binding]; other site
1185652017612	phosphorylation site [posttranslational modification]
1185652017613	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652017614	ATP binding site [chemical binding]; other site
1185652017615	Mg2+ binding site [ion binding]; other site
1185652017616	G-X-G motif; other site
1185652017617	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
1185652017618	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1185652017619	ATP binding site [chemical binding]; other site
1185652017620	putative Mg++ binding site [ion binding]; other site
1185652017621	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1185652017622	nucleotide binding region [chemical binding]; other site
1185652017623	ATP-binding site [chemical binding]; other site
1185652017624	Helicase associated domain (HA2); Region: HA2; pfam04408
1185652017625	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
1185652017626	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136
1185652017627	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652017628	Walker A/P-loop; other site
1185652017629	ATP binding site [chemical binding]; other site
1185652017630	Q-loop/lid; other site
1185652017631	ABC transporter signature motif; other site
1185652017632	Walker B; other site
1185652017633	D-loop; other site
1185652017634	H-loop/switch region; other site
1185652017635	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135
1185652017636	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1185652017637	hypothetical protein; Provisional; Region: PRK11622
1185652017638	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
1185652017639	ornithine cyclodeaminase; Validated; Region: PRK06141
1185652017640	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1185652017641	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
1185652017642	Dienelactone hydrolase family; Region: DLH; pfam01738
1185652017643	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1185652017644	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652017645	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1185652017646	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652017647	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1185652017648	Src homology 2 (SH2) domain; Region: SH2; cl15255
1185652017649	phosphotyrosine binding pocket [polypeptide binding]; other site
1185652017650	hydrophobic binding pocket [polypeptide binding]; other site
1185652017651	Homeodomain-like domain; Region: HTH_23; pfam13384
1185652017652	Winged helix-turn helix; Region: HTH_29; pfam13551
1185652017653	Winged helix-turn helix; Region: HTH_33; pfam13592
1185652017654	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1185652017655	Transposase; Region: HTH_Tnp_1; pfam01527
1185652017656	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652017657	metabolite-proton symporter; Region: 2A0106; TIGR00883
1185652017658	putative substrate translocation pore; other site
1185652017659	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1185652017660	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652017661	dimer interface [polypeptide binding]; other site
1185652017662	phosphorylation site [posttranslational modification]
1185652017663	Response regulator receiver domain; Region: Response_reg; pfam00072
1185652017664	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652017665	active site
1185652017666	phosphorylation site [posttranslational modification]
1185652017667	intermolecular recognition site; other site
1185652017668	dimerization interface [polypeptide binding]; other site
1185652017669	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
1185652017670	cyclase homology domain; Region: CHD; cd07302
1185652017671	nucleotidyl binding site; other site
1185652017672	metal binding site [ion binding]; metal-binding site
1185652017673	dimer interface [polypeptide binding]; other site
1185652017674	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1185652017675	dimerization interface [polypeptide binding]; other site
1185652017676	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1185652017677	PAS domain; Region: PAS; smart00091
1185652017678	putative active site [active]
1185652017679	heme pocket [chemical binding]; other site
1185652017680	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652017681	dimer interface [polypeptide binding]; other site
1185652017682	phosphorylation site [posttranslational modification]
1185652017683	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652017684	ATP binding site [chemical binding]; other site
1185652017685	Mg2+ binding site [ion binding]; other site
1185652017686	G-X-G motif; other site
1185652017687	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652017688	Response regulator receiver domain; Region: Response_reg; pfam00072
1185652017689	active site
1185652017690	phosphorylation site [posttranslational modification]
1185652017691	intermolecular recognition site; other site
1185652017692	dimerization interface [polypeptide binding]; other site
1185652017693	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1185652017694	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652017695	active site
1185652017696	phosphorylation site [posttranslational modification]
1185652017697	intermolecular recognition site; other site
1185652017698	dimerization interface [polypeptide binding]; other site
1185652017699	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
1185652017700	Domain of unknown function (DUF4304); Region: DUF4304; pfam14137
1185652017701	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1185652017702	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1185652017703	metal-binding site [ion binding]
1185652017704	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1185652017705	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1185652017706	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1185652017707	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1185652017708	Walker A/P-loop; other site
1185652017709	ATP binding site [chemical binding]; other site
1185652017710	Q-loop/lid; other site
1185652017711	ABC transporter signature motif; other site
1185652017712	Walker B; other site
1185652017713	D-loop; other site
1185652017714	H-loop/switch region; other site
1185652017715	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1185652017716	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652017717	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1185652017718	TM-ABC transporter signature motif; other site
1185652017719	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1185652017720	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1185652017721	TM-ABC transporter signature motif; other site
1185652017722	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1185652017723	active site
1185652017724	catalytic motif [active]
1185652017725	Zn binding site [ion binding]; other site
1185652017726	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1185652017727	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
1185652017728	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1185652017729	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1185652017730	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
1185652017731	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
1185652017732	catalytic motif [active]
1185652017733	Catalytic residue [active]
1185652017734	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1185652017735	active site
1185652017736	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1185652017737	adenosine deaminase; Provisional; Region: PRK09358
1185652017738	active site
1185652017739	phosphopentomutase; Provisional; Region: PRK05362
1185652017740	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1185652017741	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1185652017742	TadE-like protein; Region: TadE; pfam07811
1185652017743	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1185652017744	TadE-like protein; Region: TadE; pfam07811
1185652017745	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
1185652017746	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
1185652017747	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
1185652017748	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
1185652017749	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1185652017750	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
1185652017751	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
1185652017752	BON domain; Region: BON; pfam04972
1185652017753	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1185652017754	Type IV pili component [Cell motility and secretion]; Region: COG5461
1185652017755	pilus (Caulobacter type) biogenesis lipoprotein CpaD; Region: pilus_cpaD; TIGR02522
1185652017756	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
1185652017757	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1185652017758	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1185652017759	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1185652017760	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1185652017761	ATP binding site [chemical binding]; other site
1185652017762	Walker A motif; other site
1185652017763	hexamer interface [polypeptide binding]; other site
1185652017764	Walker B motif; other site
1185652017765	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1185652017766	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1185652017767	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
1185652017768	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1185652017769	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
1185652017770	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652017771	TPR motif; other site
1185652017772	binding surface
1185652017773	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
1185652017774	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1185652017775	interface (dimer of trimers) [polypeptide binding]; other site
1185652017776	Substrate-binding/catalytic site; other site
1185652017777	Zn-binding sites [ion binding]; other site
1185652017778	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1185652017779	MarR family; Region: MarR_2; cl17246
1185652017780	Src Homology 3 domain superfamily; Region: SH3; cl17036
1185652017781	peptide ligand binding site [polypeptide binding]; other site
1185652017782	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1185652017783	NlpC/P60 family; Region: NLPC_P60; cl17555
1185652017784	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1185652017785	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
1185652017786	putative ligand binding site [chemical binding]; other site
1185652017787	NAD binding site [chemical binding]; other site
1185652017788	dimerization interface [polypeptide binding]; other site
1185652017789	catalytic site [active]
1185652017790	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
1185652017791	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652017792	Walker A/P-loop; other site
1185652017793	ATP binding site [chemical binding]; other site
1185652017794	Q-loop/lid; other site
1185652017795	ABC transporter signature motif; other site
1185652017796	Walker B; other site
1185652017797	D-loop; other site
1185652017798	H-loop/switch region; other site
1185652017799	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1185652017800	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1185652017801	Walker A/P-loop; other site
1185652017802	ATP binding site [chemical binding]; other site
1185652017803	Q-loop/lid; other site
1185652017804	ABC transporter signature motif; other site
1185652017805	Walker B; other site
1185652017806	D-loop; other site
1185652017807	H-loop/switch region; other site
1185652017808	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1185652017809	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
1185652017810	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652017811	dimer interface [polypeptide binding]; other site
1185652017812	conserved gate region; other site
1185652017813	putative PBP binding loops; other site
1185652017814	ABC-ATPase subunit interface; other site
1185652017815	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
1185652017816	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652017817	dimer interface [polypeptide binding]; other site
1185652017818	conserved gate region; other site
1185652017819	putative PBP binding loops; other site
1185652017820	ABC-ATPase subunit interface; other site
1185652017821	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1185652017822	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
1185652017823	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
1185652017824	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
1185652017825	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
1185652017826	active site
1185652017827	dimer interfaces [polypeptide binding]; other site
1185652017828	catalytic residues [active]
1185652017829	glucokinase; Provisional; Region: glk; PRK00292
1185652017830	glucokinase, proteobacterial type; Region: glk; TIGR00749
1185652017831	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1185652017832	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1185652017833	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
1185652017834	Walker A/P-loop; other site
1185652017835	ATP binding site [chemical binding]; other site
1185652017836	Q-loop/lid; other site
1185652017837	ABC transporter signature motif; other site
1185652017838	Walker B; other site
1185652017839	D-loop; other site
1185652017840	H-loop/switch region; other site
1185652017841	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
1185652017842	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1185652017843	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1185652017844	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1185652017845	catalytic core [active]
1185652017846	Helix-turn-helix domain; Region: HTH_18; pfam12833
1185652017847	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1185652017848	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1185652017849	DNA binding site [nucleotide binding]
1185652017850	active site
1185652017851	Integral membrane protein [Function unknown]; Region: COG5488
1185652017852	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1185652017853	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1185652017854	minor groove reading motif; other site
1185652017855	helix-hairpin-helix signature motif; other site
1185652017856	substrate binding pocket [chemical binding]; other site
1185652017857	active site
1185652017858	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1185652017859	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652017860	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
1185652017861	putative dimer interface [polypeptide binding]; other site
1185652017862	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652017863	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
1185652017864	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1185652017865	substrate binding site [chemical binding]; other site
1185652017866	ATP binding site [chemical binding]; other site
1185652017867	Predicted kinase [General function prediction only]; Region: COG0645
1185652017868	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1185652017869	active site
1185652017870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
1185652017871	Bacterial SH3 domain; Region: SH3_4; pfam06347
1185652017872	Bacterial SH3 domain; Region: SH3_4; pfam06347
1185652017873	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1185652017874	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1185652017875	dimerization interface [polypeptide binding]; other site
1185652017876	ligand binding site [chemical binding]; other site
1185652017877	NADP binding site [chemical binding]; other site
1185652017878	catalytic site [active]
1185652017879	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1185652017880	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
1185652017881	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1185652017882	ATP binding site [chemical binding]; other site
1185652017883	substrate interface [chemical binding]; other site
1185652017884	recombination protein F; Reviewed; Region: recF; PRK00064
1185652017885	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1185652017886	Walker A/P-loop; other site
1185652017887	ATP binding site [chemical binding]; other site
1185652017888	Q-loop/lid; other site
1185652017889	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652017890	ABC transporter signature motif; other site
1185652017891	Walker B; other site
1185652017892	D-loop; other site
1185652017893	H-loop/switch region; other site
1185652017894	Protein of unknown function DUF47; Region: PhoU_div; pfam01865
1185652017895	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1185652017896	Uncharacterized conserved protein [Function unknown]; Region: COG5588
1185652017897	Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486
1185652017898	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
1185652017899	chaperone protein DnaJ; Provisional; Region: PRK10767
1185652017900	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1185652017901	HSP70 interaction site [polypeptide binding]; other site
1185652017902	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1185652017903	substrate binding site [polypeptide binding]; other site
1185652017904	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1185652017905	Zn binding sites [ion binding]; other site
1185652017906	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1185652017907	dimer interface [polypeptide binding]; other site
1185652017908	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1185652017909	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
1185652017910	nucleotide binding site [chemical binding]; other site
1185652017911	NEF interaction site [polypeptide binding]; other site
1185652017912	SBD interface [polypeptide binding]; other site
1185652017913	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1185652017914	Transglycosylase; Region: Transgly; pfam00912
1185652017915	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1185652017916	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1185652017917	EamA-like transporter family; Region: EamA; pfam00892
1185652017918	EamA-like transporter family; Region: EamA; pfam00892
1185652017919	Predicted integral membrane protein [Function unknown]; Region: COG0392
1185652017920	hypothetical protein; Validated; Region: PRK09104
1185652017921	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
1185652017922	metal binding site [ion binding]; metal-binding site
1185652017923	putative dimer interface [polypeptide binding]; other site
1185652017924	MarR family; Region: MarR; pfam01047
1185652017925	5'-3' exonuclease; Region: 53EXOc; smart00475
1185652017926	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1185652017927	active site
1185652017928	metal binding site 1 [ion binding]; metal-binding site
1185652017929	putative 5' ssDNA interaction site; other site
1185652017930	metal binding site 3; metal-binding site
1185652017931	metal binding site 2 [ion binding]; metal-binding site
1185652017932	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1185652017933	putative DNA binding site [nucleotide binding]; other site
1185652017934	putative metal binding site [ion binding]; other site
1185652017935	DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749
1185652017936	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
1185652017937	active site
1185652017938	catalytic site [active]
1185652017939	substrate binding site [chemical binding]; other site
1185652017940	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1185652017941	active site
1185652017942	DNA binding site [nucleotide binding]
1185652017943	catalytic site [active]
1185652017944	CheB methylesterase; Region: CheB_methylest; pfam01339
1185652017945	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1185652017946	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1185652017947	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
1185652017948	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1185652017949	Protein export membrane protein; Region: SecD_SecF; cl14618
1185652017950	Protein export membrane protein; Region: SecD_SecF; cl14618
1185652017951	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
1185652017952	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1185652017953	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652017954	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1185652017955	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652017956	Walker A/P-loop; other site
1185652017957	ATP binding site [chemical binding]; other site
1185652017958	Q-loop/lid; other site
1185652017959	ABC transporter signature motif; other site
1185652017960	Walker B; other site
1185652017961	D-loop; other site
1185652017962	H-loop/switch region; other site
1185652017963	TOBE domain; Region: TOBE_2; pfam08402
1185652017964	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652017965	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652017966	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652017967	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652017968	dimer interface [polypeptide binding]; other site
1185652017969	conserved gate region; other site
1185652017970	putative PBP binding loops; other site
1185652017971	ABC-ATPase subunit interface; other site
1185652017972	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1185652017973	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652017974	dimer interface [polypeptide binding]; other site
1185652017975	conserved gate region; other site
1185652017976	putative PBP binding loops; other site
1185652017977	ABC-ATPase subunit interface; other site
1185652017978	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652017979	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1185652017980	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
1185652017981	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1185652017982	putative active site [active]
1185652017983	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
1185652017984	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1185652017985	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1185652017986	DNA-binding site [nucleotide binding]; DNA binding site
1185652017987	UTRA domain; Region: UTRA; pfam07702
1185652017988	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1185652017989	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1185652017990	dimer interface [polypeptide binding]; other site
1185652017991	active site
1185652017992	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1185652017993	dimer interface [polypeptide binding]; other site
1185652017994	active site
1185652017995	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1185652017996	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1185652017997	active site
1185652017998	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
1185652017999	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1185652018000	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1185652018001	nucleotide binding site [chemical binding]; other site
1185652018002	hypothetical protein; Provisional; Region: PRK06102
1185652018003	Amidase; Region: Amidase; cl11426
1185652018004	CysZ-like protein; Reviewed; Region: PRK12768
1185652018005	hypothetical protein; Provisional; Region: PRK00736
1185652018006	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1185652018007	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1185652018008	ligand binding site [chemical binding]; other site
1185652018009	methionine sulfoxide reductase A; Provisional; Region: PRK00058
1185652018010	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1185652018011	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1185652018012	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652018013	Walker A/P-loop; other site
1185652018014	ATP binding site [chemical binding]; other site
1185652018015	Q-loop/lid; other site
1185652018016	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1185652018017	ABC transporter signature motif; other site
1185652018018	Walker B; other site
1185652018019	D-loop; other site
1185652018020	ABC transporter; Region: ABC_tran_2; pfam12848
1185652018021	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1185652018022	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
1185652018023	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898
1185652018024	putative hydrophobic ligand binding site [chemical binding]; other site
1185652018025	BON domain; Region: BON; pfam04972
1185652018026	Predicted permeases [General function prediction only]; Region: COG0679
1185652018027	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1185652018028	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1185652018029	homodimer interface [polypeptide binding]; other site
1185652018030	substrate-cofactor binding pocket; other site
1185652018031	catalytic residue [active]
1185652018032	Cytochrome c2 [Energy production and conversion]; Region: COG3474
1185652018033	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1185652018034	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1185652018035	Ligand binding site; other site
1185652018036	oligomer interface; other site
1185652018037	prephenate dehydratase; Provisional; Region: PRK11899
1185652018038	Prephenate dehydratase; Region: PDT; pfam00800
1185652018039	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1185652018040	putative L-Phe binding site [chemical binding]; other site
1185652018041	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
1185652018042	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1185652018043	active site
1185652018044	Predicted transcriptional regulator [Transcription]; Region: COG2378
1185652018045	HTH domain; Region: HTH_11; pfam08279
1185652018046	WYL domain; Region: WYL; pfam13280
1185652018047	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
1185652018048	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
1185652018049	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1185652018050	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1185652018051	putative NADH binding site [chemical binding]; other site
1185652018052	putative active site [active]
1185652018053	nudix motif; other site
1185652018054	putative metal binding site [ion binding]; other site
1185652018055	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
1185652018056	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652018057	Walker A motif; other site
1185652018058	ATP binding site [chemical binding]; other site
1185652018059	Walker B motif; other site
1185652018060	arginine finger; other site
1185652018061	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1185652018062	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
1185652018063	hypothetical protein; Validated; Region: PRK00153
1185652018064	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1185652018065	recombination protein RecR; Reviewed; Region: recR; PRK00076
1185652018066	RecR protein; Region: RecR; pfam02132
1185652018067	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1185652018068	putative active site [active]
1185652018069	putative metal-binding site [ion binding]; other site
1185652018070	tetramer interface [polypeptide binding]; other site
1185652018071	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1185652018072	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1185652018073	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1185652018074	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1185652018075	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1185652018076	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
1185652018077	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1185652018078	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1185652018079	SelR domain; Region: SelR; pfam01641
1185652018080	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
1185652018081	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1185652018082	potential catalytic triad [active]
1185652018083	conserved cys residue [active]
1185652018084	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1185652018085	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1185652018086	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
1185652018087	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1185652018088	catalytic residues [active]
1185652018089	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1185652018090	classical (c) SDRs; Region: SDR_c; cd05233
1185652018091	NAD(P) binding site [chemical binding]; other site
1185652018092	active site
1185652018093	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1185652018094	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1185652018095	conserved cys residue [active]
1185652018096	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652018097	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1185652018098	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1185652018099	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652018100	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1185652018101	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1185652018102	dimerization interface [polypeptide binding]; other site
1185652018103	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652018104	dimer interface [polypeptide binding]; other site
1185652018105	phosphorylation site [posttranslational modification]
1185652018106	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652018107	ATP binding site [chemical binding]; other site
1185652018108	Mg2+ binding site [ion binding]; other site
1185652018109	G-X-G motif; other site
1185652018110	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1185652018111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652018112	active site
1185652018113	phosphorylation site [posttranslational modification]
1185652018114	intermolecular recognition site; other site
1185652018115	dimerization interface [polypeptide binding]; other site
1185652018116	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652018117	DNA binding site [nucleotide binding]
1185652018118	Cupin domain; Region: Cupin_2; pfam07883
1185652018119	Transmembrane secretion effector; Region: MFS_3; pfam05977
1185652018120	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652018121	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1185652018122	Sm and related proteins; Region: Sm_like; cl00259
1185652018123	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1185652018124	putative oligomer interface [polypeptide binding]; other site
1185652018125	putative RNA binding site [nucleotide binding]; other site
1185652018126	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
1185652018127	NusA N-terminal domain; Region: NusA_N; pfam08529
1185652018128	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1185652018129	RNA binding site [nucleotide binding]; other site
1185652018130	homodimer interface [polypeptide binding]; other site
1185652018131	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1185652018132	G-X-X-G motif; other site
1185652018133	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1185652018134	G-X-X-G motif; other site
1185652018135	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1185652018136	hypothetical protein; Provisional; Region: PRK09190
1185652018137	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1185652018138	putative RNA binding cleft [nucleotide binding]; other site
1185652018139	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
1185652018140	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1185652018141	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
1185652018142	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1185652018143	G1 box; other site
1185652018144	putative GEF interaction site [polypeptide binding]; other site
1185652018145	GTP/Mg2+ binding site [chemical binding]; other site
1185652018146	Switch I region; other site
1185652018147	G2 box; other site
1185652018148	G3 box; other site
1185652018149	Switch II region; other site
1185652018150	G4 box; other site
1185652018151	G5 box; other site
1185652018152	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1185652018153	Translation-initiation factor 2; Region: IF-2; pfam11987
1185652018154	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1185652018155	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1185652018156	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
1185652018157	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1185652018158	RNA binding site [nucleotide binding]; other site
1185652018159	active site
1185652018160	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
1185652018161	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1185652018162	HWE histidine kinase; Region: HWE_HK; pfam07536
1185652018163	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1185652018164	16S/18S rRNA binding site [nucleotide binding]; other site
1185652018165	S13e-L30e interaction site [polypeptide binding]; other site
1185652018166	25S rRNA binding site [nucleotide binding]; other site
1185652018167	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1185652018168	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1185652018169	RNase E interface [polypeptide binding]; other site
1185652018170	trimer interface [polypeptide binding]; other site
1185652018171	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1185652018172	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1185652018173	RNase E interface [polypeptide binding]; other site
1185652018174	trimer interface [polypeptide binding]; other site
1185652018175	active site
1185652018176	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1185652018177	putative nucleic acid binding region [nucleotide binding]; other site
1185652018178	G-X-X-G motif; other site
1185652018179	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1185652018180	RNA binding site [nucleotide binding]; other site
1185652018181	domain interface; other site
1185652018182	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
1185652018183	Methyltransferase small domain; Region: MTS; pfam05175
1185652018184	S-adenosylmethionine binding site [chemical binding]; other site
1185652018185	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
1185652018186	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1185652018187	NAD binding site [chemical binding]; other site
1185652018188	homotetramer interface [polypeptide binding]; other site
1185652018189	homodimer interface [polypeptide binding]; other site
1185652018190	substrate binding site [chemical binding]; other site
1185652018191	active site
1185652018192	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
1185652018193	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1185652018194	dimer interface [polypeptide binding]; other site
1185652018195	active site
1185652018196	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
1185652018197	active site 1 [active]
1185652018198	dimer interface [polypeptide binding]; other site
1185652018199	active site 2 [active]
1185652018200	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1185652018201	metal binding site 2 [ion binding]; metal-binding site
1185652018202	putative DNA binding helix; other site
1185652018203	metal binding site 1 [ion binding]; metal-binding site
1185652018204	dimer interface [polypeptide binding]; other site
1185652018205	Predicted membrane protein [Function unknown]; Region: COG2860
1185652018206	UPF0126 domain; Region: UPF0126; pfam03458
1185652018207	UPF0126 domain; Region: UPF0126; pfam03458
1185652018208	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1185652018209	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1185652018210	putative active site [active]
1185652018211	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1185652018212	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1185652018213	hinge; other site
1185652018214	active site
1185652018215	cytidylate kinase; Provisional; Region: cmk; PRK00023
1185652018216	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1185652018217	CMP-binding site; other site
1185652018218	The sites determining sugar specificity; other site
1185652018219	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
1185652018220	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1185652018221	RNA binding site [nucleotide binding]; other site
1185652018222	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1185652018223	RNA binding site [nucleotide binding]; other site
1185652018224	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1185652018225	RNA binding site [nucleotide binding]; other site
1185652018226	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1185652018227	RNA binding site [nucleotide binding]; other site
1185652018228	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1185652018229	RNA binding site [nucleotide binding]; other site
1185652018230	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
1185652018231	RNA binding site [nucleotide binding]; other site
1185652018232	Cache domain; Region: Cache_1; pfam02743
1185652018233	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1185652018234	dimerization interface [polypeptide binding]; other site
1185652018235	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1185652018236	cyclase homology domain; Region: CHD; cd07302
1185652018237	nucleotidyl binding site; other site
1185652018238	metal binding site [ion binding]; metal-binding site
1185652018239	dimer interface [polypeptide binding]; other site
1185652018240	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1185652018241	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1185652018242	NAD binding site [chemical binding]; other site
1185652018243	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
1185652018244	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1185652018245	catalytic site [active]
1185652018246	putative active site [active]
1185652018247	putative substrate binding site [chemical binding]; other site
1185652018248	Predicted membrane protein [Function unknown]; Region: COG1238
1185652018249	Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526
1185652018250	Predicted membrane protein [Function unknown]; Region: COG2259
1185652018251	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1185652018252	maltose O-acetyltransferase; Provisional; Region: PRK10092
1185652018253	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1185652018254	active site
1185652018255	substrate binding site [chemical binding]; other site
1185652018256	trimer interface [polypeptide binding]; other site
1185652018257	CoA binding site [chemical binding]; other site
1185652018258	GTP-binding protein LepA; Provisional; Region: PRK05433
1185652018259	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1185652018260	G1 box; other site
1185652018261	putative GEF interaction site [polypeptide binding]; other site
1185652018262	GTP/Mg2+ binding site [chemical binding]; other site
1185652018263	Switch I region; other site
1185652018264	G2 box; other site
1185652018265	G3 box; other site
1185652018266	Switch II region; other site
1185652018267	G4 box; other site
1185652018268	G5 box; other site
1185652018269	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1185652018270	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1185652018271	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1185652018272	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652018273	putative substrate translocation pore; other site
1185652018274	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1185652018275	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652018276	non-specific DNA binding site [nucleotide binding]; other site
1185652018277	salt bridge; other site
1185652018278	sequence-specific DNA binding site [nucleotide binding]; other site
1185652018279	Cupin domain; Region: Cupin_2; pfam07883
1185652018280	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1185652018281	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
1185652018282	active site
1185652018283	Zn binding site [ion binding]; other site
1185652018284	putative outer membrane lipoprotein; Provisional; Region: PRK10510
1185652018285	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1185652018286	ligand binding site [chemical binding]; other site
1185652018287	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
1185652018288	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1185652018289	FeS/SAM binding site; other site
1185652018290	Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269
1185652018291	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1185652018292	motif 1; other site
1185652018293	dimer interface [polypeptide binding]; other site
1185652018294	active site
1185652018295	motif 2; other site
1185652018296	motif 3; other site
1185652018297	elongation factor P; Validated; Region: PRK00529
1185652018298	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1185652018299	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1185652018300	RNA binding site [nucleotide binding]; other site
1185652018301	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1185652018302	RNA binding site [nucleotide binding]; other site
1185652018303	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1185652018304	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1185652018305	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652018306	S-adenosylmethionine binding site [chemical binding]; other site
1185652018307	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
1185652018308	diiron binding motif [ion binding]; other site
1185652018309	Uncharacterized conserved protein [Function unknown]; Region: COG1633
1185652018310	CCC1-related protein family; Region: CCC1_like_1; cd02437
1185652018311	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
1185652018312	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1185652018313	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1185652018314	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1185652018315	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1185652018316	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1185652018317	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652018318	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652018319	active site
1185652018320	phosphorylation site [posttranslational modification]
1185652018321	intermolecular recognition site; other site
1185652018322	dimerization interface [polypeptide binding]; other site
1185652018323	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652018324	DNA binding site [nucleotide binding]
1185652018325	sensor protein PhoQ; Provisional; Region: PRK10815
1185652018326	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652018327	ATP binding site [chemical binding]; other site
1185652018328	Mg2+ binding site [ion binding]; other site
1185652018329	G-X-G motif; other site
1185652018330	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1185652018331	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1185652018332	23S rRNA binding site [nucleotide binding]; other site
1185652018333	L21 binding site [polypeptide binding]; other site
1185652018334	L13 binding site [polypeptide binding]; other site
1185652018335	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1185652018336	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1185652018337	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1185652018338	dimer interface [polypeptide binding]; other site
1185652018339	motif 1; other site
1185652018340	active site
1185652018341	motif 2; other site
1185652018342	motif 3; other site
1185652018343	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1185652018344	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1185652018345	putative tRNA-binding site [nucleotide binding]; other site
1185652018346	B3/4 domain; Region: B3_4; pfam03483
1185652018347	tRNA synthetase B5 domain; Region: B5; smart00874
1185652018348	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1185652018349	dimer interface [polypeptide binding]; other site
1185652018350	motif 1; other site
1185652018351	motif 3; other site
1185652018352	motif 2; other site
1185652018353	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
1185652018354	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
1185652018355	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1185652018356	dimer interface [polypeptide binding]; other site
1185652018357	putative metal binding site [ion binding]; other site
1185652018358	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
1185652018359	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1185652018360	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1185652018361	active site
1185652018362	catalytic tetrad [active]
1185652018363	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652018364	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652018365	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
1185652018366	putative effector binding pocket; other site
1185652018367	putative dimerization interface [polypeptide binding]; other site
1185652018368	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
1185652018369	dimerization interface [polypeptide binding]; other site
1185652018370	metal binding site [ion binding]; metal-binding site
1185652018371	short chain dehydrogenase; Provisional; Region: PRK07478
1185652018372	classical (c) SDRs; Region: SDR_c; cd05233
1185652018373	NAD(P) binding site [chemical binding]; other site
1185652018374	active site
1185652018375	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1185652018376	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1185652018377	active site
1185652018378	catalytic tetrad [active]
1185652018379	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652018380	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652018381	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1185652018382	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1185652018383	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1185652018384	generic binding surface II; other site
1185652018385	generic binding surface I; other site
1185652018386	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1185652018387	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1185652018388	MarR family; Region: MarR_2; cl17246
1185652018389	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1185652018390	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1185652018391	EamA-like transporter family; Region: EamA; pfam00892
1185652018392	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1185652018393	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1185652018394	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1185652018395	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1185652018396	C-terminal domain interface [polypeptide binding]; other site
1185652018397	GSH binding site (G-site) [chemical binding]; other site
1185652018398	dimer interface [polypeptide binding]; other site
1185652018399	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1185652018400	N-terminal domain interface [polypeptide binding]; other site
1185652018401	dimer interface [polypeptide binding]; other site
1185652018402	substrate binding pocket (H-site) [chemical binding]; other site
1185652018403	MarR family; Region: MarR_2; pfam12802
1185652018404	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1185652018405	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1185652018406	putative deacylase active site [active]
1185652018407	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
1185652018408	ArsC family; Region: ArsC; pfam03960
1185652018409	putative catalytic residues [active]
1185652018410	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1185652018411	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1185652018412	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1185652018413	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652018414	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652018415	homodimer interface [polypeptide binding]; other site
1185652018416	catalytic residue [active]
1185652018417	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652018418	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652018419	dimerization interface [polypeptide binding]; other site
1185652018420	putative DNA binding site [nucleotide binding]; other site
1185652018421	putative Zn2+ binding site [ion binding]; other site
1185652018422	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652018423	Predicted deacylase [General function prediction only]; Region: COG3608
1185652018424	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
1185652018425	active site
1185652018426	Zn binding site [ion binding]; other site
1185652018427	GMP synthase; Reviewed; Region: guaA; PRK00074
1185652018428	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1185652018429	AMP/PPi binding site [chemical binding]; other site
1185652018430	candidate oxyanion hole; other site
1185652018431	catalytic triad [active]
1185652018432	potential glutamine specificity residues [chemical binding]; other site
1185652018433	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1185652018434	ATP Binding subdomain [chemical binding]; other site
1185652018435	Ligand Binding sites [chemical binding]; other site
1185652018436	Dimerization subdomain; other site
1185652018437	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026
1185652018438	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705
1185652018439	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1185652018440	CoenzymeA binding site [chemical binding]; other site
1185652018441	subunit interaction site [polypeptide binding]; other site
1185652018442	PHB binding site; other site
1185652018443	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1185652018444	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652018445	Coenzyme A binding pocket [chemical binding]; other site
1185652018446	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490
1185652018447	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1185652018448	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
1185652018449	Cl binding site [ion binding]; other site
1185652018450	oligomer interface [polypeptide binding]; other site
1185652018451	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG3489
1185652018452	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
1185652018453	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
1185652018454	Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]; Region: IrpA; COG3487
1185652018455	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
1185652018456	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652018457	S-adenosylmethionine binding site [chemical binding]; other site
1185652018458	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
1185652018459	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1185652018460	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652018461	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
1185652018462	putative NAD(P) binding site [chemical binding]; other site
1185652018463	epoxyqueuosine reductase; Region: TIGR00276
1185652018464	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1185652018465	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1185652018466	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1185652018467	C-terminal domain interface [polypeptide binding]; other site
1185652018468	GSH binding site (G-site) [chemical binding]; other site
1185652018469	dimer interface [polypeptide binding]; other site
1185652018470	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
1185652018471	N-terminal domain interface [polypeptide binding]; other site
1185652018472	dimer interface [polypeptide binding]; other site
1185652018473	substrate binding pocket (H-site) [chemical binding]; other site
1185652018474	Undecaprenyl pyrophosphate phosphatase [Lipid transport and metabolism]; Region: BacA; COG1968
1185652018475	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1185652018476	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
1185652018477	putative NAD(P) binding site [chemical binding]; other site
1185652018478	active site
1185652018479	Uncharacterized conserved protein [Function unknown]; Region: COG5470
1185652018480	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1185652018481	active site
1185652018482	dimer interface [polypeptide binding]; other site
1185652018483	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
1185652018484	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1185652018485	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652018486	S-adenosylmethionine binding site [chemical binding]; other site
1185652018487	DNA polymerase III subunit beta; Validated; Region: PRK05643
1185652018488	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1185652018489	putative DNA binding surface [nucleotide binding]; other site
1185652018490	dimer interface [polypeptide binding]; other site
1185652018491	beta-clamp/clamp loader binding surface; other site
1185652018492	beta-clamp/translesion DNA polymerase binding surface; other site
1185652018493	Predicted methyltransferases [General function prediction only]; Region: COG0313
1185652018494	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1185652018495	putative SAM binding site [chemical binding]; other site
1185652018496	putative homodimer interface [polypeptide binding]; other site
1185652018497	hypothetical protein; Reviewed; Region: PRK12497
1185652018498	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1185652018499	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1185652018500	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1185652018501	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1185652018502	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1185652018503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652018504	dimer interface [polypeptide binding]; other site
1185652018505	conserved gate region; other site
1185652018506	putative PBP binding loops; other site
1185652018507	ABC-ATPase subunit interface; other site
1185652018508	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1185652018509	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1185652018510	Walker A/P-loop; other site
1185652018511	ATP binding site [chemical binding]; other site
1185652018512	Q-loop/lid; other site
1185652018513	ABC transporter signature motif; other site
1185652018514	Walker B; other site
1185652018515	D-loop; other site
1185652018516	H-loop/switch region; other site
1185652018517	TOBE domain; Region: TOBE_2; pfam08402
1185652018518	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1185652018519	putative catalytic site [active]
1185652018520	putative phosphate binding site [ion binding]; other site
1185652018521	putative metal binding site [ion binding]; other site
1185652018522	glutathione synthetase; Provisional; Region: PRK05246
1185652018523	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
1185652018524	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
1185652018525	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1185652018526	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1185652018527	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652018528	Walker A motif; other site
1185652018529	ATP binding site [chemical binding]; other site
1185652018530	Walker B motif; other site
1185652018531	arginine finger; other site
1185652018532	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1185652018533	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1185652018534	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1185652018535	dimer interface [polypeptide binding]; other site
1185652018536	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652018537	catalytic residue [active]
1185652018538	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1185652018539	NIPSNAP; Region: NIPSNAP; pfam07978
1185652018540	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1185652018541	EamA-like transporter family; Region: EamA; pfam00892
1185652018542	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1185652018543	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1185652018544	putative DNA binding site [nucleotide binding]; other site
1185652018545	putative Zn2+ binding site [ion binding]; other site
1185652018546	AsnC family; Region: AsnC_trans_reg; pfam01037
1185652018547	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1185652018548	trimer interface [polypeptide binding]; other site
1185652018549	active site
1185652018550	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
1185652018551	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1185652018552	G1 box; other site
1185652018553	putative GEF interaction site [polypeptide binding]; other site
1185652018554	GTP/Mg2+ binding site [chemical binding]; other site
1185652018555	Switch I region; other site
1185652018556	G2 box; other site
1185652018557	G3 box; other site
1185652018558	Switch II region; other site
1185652018559	G4 box; other site
1185652018560	G5 box; other site
1185652018561	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1185652018562	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1185652018563	EamA-like transporter family; Region: EamA; pfam00892
1185652018564	EamA-like transporter family; Region: EamA; pfam00892
1185652018565	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1185652018566	Helix-turn-helix domain; Region: HTH_18; pfam12833
1185652018567	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1185652018568	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652018569	non-specific DNA binding site [nucleotide binding]; other site
1185652018570	salt bridge; other site
1185652018571	sequence-specific DNA binding site [nucleotide binding]; other site
1185652018572	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1185652018573	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1185652018574	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652018575	NAD(P) binding site [chemical binding]; other site
1185652018576	active site
1185652018577	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1185652018578	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
1185652018579	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1185652018580	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1185652018581	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1185652018582	dimer interface [polypeptide binding]; other site
1185652018583	PYR/PP interface [polypeptide binding]; other site
1185652018584	TPP binding site [chemical binding]; other site
1185652018585	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1185652018586	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1185652018587	TPP-binding site [chemical binding]; other site
1185652018588	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1185652018589	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1185652018590	substrate binding site [chemical binding]; other site
1185652018591	ATP binding site [chemical binding]; other site
1185652018592	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
1185652018593	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
1185652018594	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1185652018595	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1185652018596	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1185652018597	putative active site [active]
1185652018598	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652018599	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652018600	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1185652018601	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
1185652018602	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1185652018603	putative active site [active]
1185652018604	putative dimer interface [polypeptide binding]; other site
1185652018605	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1185652018606	Flavoprotein; Region: Flavoprotein; pfam02441
1185652018607	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1185652018608	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1185652018609	substrate binding site [chemical binding]; other site
1185652018610	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1185652018611	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1185652018612	putative acetyltransferase YhhY; Provisional; Region: PRK10140
1185652018613	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1185652018614	Coenzyme A binding pocket [chemical binding]; other site
1185652018615	ABC1 family; Region: ABC1; cl17513
1185652018616	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
1185652018617	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1185652018618	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652018619	S-adenosylmethionine binding site [chemical binding]; other site
1185652018620	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1185652018621	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1185652018622	DNA binding site [nucleotide binding]
1185652018623	catalytic residue [active]
1185652018624	H2TH interface [polypeptide binding]; other site
1185652018625	putative catalytic residues [active]
1185652018626	turnover-facilitating residue; other site
1185652018627	intercalation triad [nucleotide binding]; other site
1185652018628	8OG recognition residue [nucleotide binding]; other site
1185652018629	putative reading head residues; other site
1185652018630	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1185652018631	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1185652018632	enoyl-CoA hydratase; Provisional; Region: PRK05862
1185652018633	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1185652018634	substrate binding site [chemical binding]; other site
1185652018635	oxyanion hole (OAH) forming residues; other site
1185652018636	trimer interface [polypeptide binding]; other site
1185652018637	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1185652018638	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
1185652018639	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
1185652018640	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
1185652018641	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1185652018642	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1185652018643	putative active site [active]
1185652018644	putative NTP binding site [chemical binding]; other site
1185652018645	putative nucleic acid binding site [nucleotide binding]; other site
1185652018646	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1185652018647	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1185652018648	putative active site [active]
1185652018649	putative NTP binding site [chemical binding]; other site
1185652018650	putative nucleic acid binding site [nucleotide binding]; other site
1185652018651	HTH-like domain; Region: HTH_21; pfam13276
1185652018652	Transposase; Region: HTH_Tnp_1; pfam01527
1185652018653	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1185652018654	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1185652018655	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1185652018656	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652018657	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1185652018658	Integrase core domain; Region: rve; pfam00665
1185652018659	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1185652018660	HipA N-terminal domain; Region: Couple_hipA; pfam13657
1185652018661	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
1185652018662	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1185652018663	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1185652018664	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652018665	non-specific DNA binding site [nucleotide binding]; other site
1185652018666	salt bridge; other site
1185652018667	sequence-specific DNA binding site [nucleotide binding]; other site
1185652018668	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652018669	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1185652018670	Integrase core domain; Region: rve; pfam00665
1185652018671	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
1185652018672	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
1185652018673	Nucleotide-binding sites [chemical binding]; other site
1185652018674	Walker A motif; other site
1185652018675	Switch I region of nucleotide binding site; other site
1185652018676	Fe4S4 binding sites [ion binding]; other site
1185652018677	Switch II region of nucleotide binding site; other site
1185652018678	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
1185652018679	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
1185652018680	MoFe protein alpha/beta subunit interactions; other site
1185652018681	Alpha subunit P cluster binding residues; other site
1185652018682	FeMoco binding residues [chemical binding]; other site
1185652018683	MoFe protein alpha subunit/Fe protein contacts; other site
1185652018684	MoFe protein dimer/ dimer interactions; other site
1185652018685	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
1185652018686	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
1185652018687	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
1185652018688	MoFe protein beta/alpha subunit interactions; other site
1185652018689	Beta subunit P cluster binding residues; other site
1185652018690	MoFe protein beta subunit/Fe protein contacts; other site
1185652018691	MoFe protein dimer/ dimer interactions; other site
1185652018692	probable nitrogen fixation protein; Region: TIGR02935
1185652018693	Rop-like; Region: Rop-like; pfam05082
1185652018694	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
1185652018695	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1185652018696	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1185652018697	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1185652018698	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
1185652018699	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
1185652018700	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1185652018701	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
1185652018702	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652018703	Walker A motif; other site
1185652018704	ATP binding site [chemical binding]; other site
1185652018705	Walker B motif; other site
1185652018706	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1185652018707	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1185652018708	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1185652018709	HTH-like domain; Region: HTH_21; pfam13276
1185652018710	Integrase core domain; Region: rve; pfam00665
1185652018711	Integrase core domain; Region: rve_3; pfam13683
1185652018712	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1185652018713	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652018714	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652018715	The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462
1185652018716	putative substrate binding pocket [chemical binding]; other site
1185652018717	putative dimerization interface [polypeptide binding]; other site
1185652018718	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652018719	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652018720	active site
1185652018721	phosphorylation site [posttranslational modification]
1185652018722	intermolecular recognition site; other site
1185652018723	dimerization interface [polypeptide binding]; other site
1185652018724	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652018725	DNA binding site [nucleotide binding]
1185652018726	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
1185652018727	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
1185652018728	BON domain; Region: BON; pfam04972
1185652018729	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1185652018730	Type IV pili component [Cell motility and secretion]; Region: COG5461
1185652018731	pilus (Caulobacter type) biogenesis lipoprotein CpaD; Region: pilus_cpaD; TIGR02522
1185652018732	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1185652018733	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1185652018734	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1185652018735	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652018736	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1185652018737	putative substrate translocation pore; other site
1185652018738	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1185652018739	IucA / IucC family; Region: IucA_IucC; pfam04183
1185652018740	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1185652018741	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
1185652018742	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1185652018743	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1185652018744	dimer interface [polypeptide binding]; other site
1185652018745	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652018746	catalytic residue [active]
1185652018747	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1185652018748	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1185652018749	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1185652018750	catalytic residue [active]
1185652018751	ParB-like nuclease domain; Region: ParBc; cl02129
1185652018752	NolX protein; Region: NolX; pfam05819
1185652018753	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1185652018754	Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669
1185652018755	Nodulation protein NolV; Region: NolV; pfam06635
1185652018756	Flagellar assembly protein FliH; Region: FliH; pfam02108
1185652018757	Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157
1185652018758	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1185652018759	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1185652018760	Walker A motif; other site
1185652018761	ATP binding site [chemical binding]; other site
1185652018762	Walker B motif; other site
1185652018763	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
1185652018764	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
1185652018765	type III secretion system protein YscR; Provisional; Region: PRK12797
1185652018766	Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794
1185652018767	type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401
1185652018768	Type III secretory pathway, component EscU [Intracellular trafficking and secretion]; Region: EscU; COG4792
1185652018769	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
1185652018770	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
1185652018771	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
1185652018772	FHIPEP family; Region: FHIPEP; pfam00771
1185652018773	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1185652018774	binding surface
1185652018775	TPR motif; other site
1185652018776	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1185652018777	Integrase core domain; Region: rve; pfam00665
1185652018778	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1185652018779	Homeodomain-like domain; Region: HTH_23; pfam13384
1185652018780	Winged helix-turn helix; Region: HTH_29; pfam13551
1185652018781	Homeodomain-like domain; Region: HTH_32; pfam13565
1185652018782	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1185652018783	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
1185652018784	Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; pfam03543
1185652018785	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
1185652018786	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652018787	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652018788	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652018789	dimerization interface [polypeptide binding]; other site
1185652018790	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
1185652018791	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
1185652018792	Active site cavity [active]
1185652018793	catalytic acid [active]
1185652018794	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1185652018795	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
1185652018796	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1185652018797	active site lid residues [active]
1185652018798	substrate binding pocket [chemical binding]; other site
1185652018799	catalytic residues [active]
1185652018800	substrate-Mg2+ binding site; other site
1185652018801	aspartate-rich region 1; other site
1185652018802	aspartate-rich region 2; other site
1185652018803	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1185652018804	active site lid residues [active]
1185652018805	substrate binding pocket [chemical binding]; other site
1185652018806	catalytic residues [active]
1185652018807	substrate-Mg2+ binding site; other site
1185652018808	aspartate-rich region 1; other site
1185652018809	aspartate-rich region 2; other site
1185652018810	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1185652018811	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1185652018812	NADP binding site [chemical binding]; other site
1185652018813	active site
1185652018814	putative substrate binding site [chemical binding]; other site
1185652018815	GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472
1185652018816	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1185652018817	NADP-binding site; other site
1185652018818	homotetramer interface [polypeptide binding]; other site
1185652018819	substrate binding site [chemical binding]; other site
1185652018820	homodimer interface [polypeptide binding]; other site
1185652018821	active site
1185652018822	Nodulation protein Z (NodZ); Region: NodZ; pfam05830
1185652018823	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
1185652018824	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
1185652018825	active site
1185652018826	substrate binding site [chemical binding]; other site
1185652018827	metal binding site [ion binding]; metal-binding site
1185652018828	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1185652018829	Substrate binding site; other site
1185652018830	Cupin domain; Region: Cupin_2; cl17218
1185652018831	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652018832	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652018833	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1185652018834	dimerization interface [polypeptide binding]; other site
1185652018835	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1185652018836	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652018837	sequence-specific DNA binding site [nucleotide binding]; other site
1185652018838	salt bridge; other site
1185652018839	Predicted transcriptional regulator [Transcription]; Region: COG4957
1185652018840	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1185652018841	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652018842	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1185652018843	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652018844	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
1185652018845	Helix-turn-helix domain; Region: HTH_28; pfam13518
1185652018846	Winged helix-turn helix; Region: HTH_29; pfam13551
1185652018847	Homeodomain-like domain; Region: HTH_32; pfam13565
1185652018848	Integrase core domain; Region: rve; pfam00665
1185652018849	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1185652018850	Helix-turn-helix domain; Region: HTH_38; pfam13936
1185652018851	Integrase core domain; Region: rve; pfam00665
1185652018852	Helix-turn-helix domain; Region: HTH_28; pfam13518
1185652018853	Winged helix-turn helix; Region: HTH_29; pfam13551
1185652018854	Homeodomain-like domain; Region: HTH_32; pfam13565
1185652018855	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
1185652018856	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1185652018857	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1185652018858	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1185652018859	Protein of unknown function (DUF968); Region: DUF968; pfam06147
1185652018860	Integrase core domain; Region: rve; pfam00665
1185652018861	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1185652018862	Transposase; Region: HTH_Tnp_1; pfam01527
1185652018863	Homeodomain-like domain; Region: HTH_23; pfam13384
1185652018864	Winged helix-turn helix; Region: HTH_29; pfam13551
1185652018865	Homeodomain-like domain; Region: HTH_32; pfam13565
1185652018866	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1185652018867	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
1185652018868	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1185652018869	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1185652018870	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1185652018871	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1185652018872	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1185652018873	homodimer interface [polypeptide binding]; other site
1185652018874	catalytic residue [active]
1185652018875	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1185652018876	putative substrate translocation pore; other site
1185652018877	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1185652018878	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1185652018879	non-specific DNA binding site [nucleotide binding]; other site
1185652018880	salt bridge; other site
1185652018881	sequence-specific DNA binding site [nucleotide binding]; other site
1185652018882	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1185652018883	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1185652018884	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1185652018885	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1185652018886	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1185652018887	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
1185652018888	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1185652018889	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
1185652018890	probable nitrogen fixation protein; Region: TIGR02935
1185652018891	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
1185652018892	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
1185652018893	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
1185652018894	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
1185652018895	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
1185652018896	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
1185652018897	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
1185652018898	MoFe protein beta/alpha subunit interactions; other site
1185652018899	Beta subunit P cluster binding residues; other site
1185652018900	MoFe protein beta subunit/Fe protein contacts; other site
1185652018901	MoFe protein dimer/ dimer interactions; other site
1185652018902	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
1185652018903	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
1185652018904	MoFe protein alpha/beta subunit interactions; other site
1185652018905	Alpha subunit P cluster binding residues; other site
1185652018906	FeMoco binding residues [chemical binding]; other site
1185652018907	MoFe protein alpha subunit/Fe protein contacts; other site
1185652018908	MoFe protein dimer/ dimer interactions; other site
1185652018909	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
1185652018910	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
1185652018911	Nucleotide-binding sites [chemical binding]; other site
1185652018912	Walker A motif; other site
1185652018913	Switch I region of nucleotide binding site; other site
1185652018914	Fe4S4 binding sites [ion binding]; other site
1185652018915	Switch II region of nucleotide binding site; other site
1185652018916	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1185652018917	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1185652018918	short chain dehydrogenase; Validated; Region: PRK06484
1185652018919	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652018920	NAD(P) binding site [chemical binding]; other site
1185652018921	active site
1185652018922	classical (c) SDRs; Region: SDR_c; cd05233
1185652018923	NAD(P) binding site [chemical binding]; other site
1185652018924	active site
1185652018925	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
1185652018926	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1185652018927	Cytochrome P450; Region: p450; cl12078
1185652018928	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
1185652018929	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1185652018930	NifQ; Region: NifQ; pfam04891
1185652018931	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
1185652018932	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1185652018933	catalytic triad [active]
1185652018934	dimer interface [polypeptide binding]; other site
1185652018935	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
1185652018936	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1185652018937	Ligand binding site [chemical binding]; other site
1185652018938	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1185652018939	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1185652018940	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1185652018941	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1185652018942	oxidoreductase; Provisional; Region: PRK10015
1185652018943	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1185652018944	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
1185652018945	Nif-specific regulatory protein; Region: nifA; TIGR01817
1185652018946	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1185652018947	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652018948	Walker A motif; other site
1185652018949	ATP binding site [chemical binding]; other site
1185652018950	Walker B motif; other site
1185652018951	arginine finger; other site
1185652018952	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1185652018953	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
1185652018954	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1185652018955	FeS/SAM binding site; other site
1185652018956	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
1185652018957	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1185652018958	Cell-cell adhesion domain; Region: Dicty_CAD; pfam05720
1185652018959	NifZ domain; Region: NifZ; pfam04319
1185652018960	NifT/FixU protein; Region: NifT; pfam06988
1185652018961	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1185652018962	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1185652018963	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1185652018964	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1185652018965	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1185652018966	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1185652018967	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1185652018968	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1185652018969	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1185652018970	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1185652018971	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
1185652018972	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1185652018973	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1185652018974	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1185652018975	catalytic residue [active]
1185652018976	nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810
1185652018977	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1185652018978	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1185652018979	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1185652018980	VirK protein; Region: VirK; pfam06903
1185652018981	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1185652018982	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
1185652018983	putative active site [active]
1185652018984	Uncharacterized conserved protein [Function unknown]; Region: COG5489
1185652018985	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
1185652018986	conjugal transfer coupling protein TraG; Provisional; Region: PRK13822
1185652018987	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
1185652018988	Walker A motif; other site
1185652018989	ATP binding site [chemical binding]; other site
1185652018990	Walker B motif; other site
1185652018991	Conjugal transfer protein TraD; Region: TraD; pfam06412
1185652018992	AAA domain; Region: AAA_30; pfam13604
1185652018993	Family description; Region: UvrD_C_2; pfam13538
1185652018994	Zeta toxin; Region: Zeta_toxin; pfam06414
1185652018995	XK-related protein; Region: XK-related; pfam09815
1185652018996	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1185652018997	Helix-turn-helix domain; Region: HTH_28; pfam13518
1185652018998	Winged helix-turn helix; Region: HTH_29; pfam13551
1185652018999	Homeodomain-like domain; Region: HTH_32; pfam13565
1185652019000	Integrase core domain; Region: rve; pfam00665
1185652019001	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1185652019002	HWE histidine kinase; Region: HWE_HK; smart00911
1185652019003	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
1185652019004	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1185652019005	Protein of unknown function (DUF1515); Region: DUF1515; pfam07439
1185652019006	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1185652019007	Acyl-CoA dehydrogenase C terminal; Region: AcylCoA_dehyd_C; pfam12186
1185652019008	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1185652019009	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1185652019010	Transposase domain (DUF772); Region: DUF772; pfam05598
1185652019011	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1185652019012	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1185652019013	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1185652019014	MULE transposase domain; Region: MULE; pfam10551
1185652019015	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
1185652019016	Bacterial TniB protein; Region: TniB; pfam05621
1185652019017	AAA domain; Region: AAA_22; pfam13401
1185652019018	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
1185652019019	Restriction endonuclease; Region: Mrr_cat; pfam04471
1185652019020	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652019021	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1185652019022	Integrase core domain; Region: rve; pfam00665
1185652019023	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
1185652019024	Leucine rich repeat; Region: LRR_8; pfam13855
1185652019025	Leucine-rich repeats; other site
1185652019026	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1185652019027	Leucine rich repeat; Region: LRR_8; pfam13855
1185652019028	FCD domain; Region: FCD; pfam07729
1185652019029	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1185652019030	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1185652019031	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
1185652019032	putative dimerization interface [polypeptide binding]; other site
1185652019033	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1185652019034	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1185652019035	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1185652019036	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1185652019037	NAD(P) binding site [chemical binding]; other site
1185652019038	catalytic residues [active]
1185652019039	Domain of unknown function (DUF4392); Region: DUF4392; pfam14336
1185652019040	pyridoxal phosphate enzyme, MJ0158 family; Region: pyridox_MJ0158; TIGR03576
1185652019041	Domain of unknown function (DUF4392); Region: DUF4392; pfam14336
1185652019042	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1185652019043	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1185652019044	substrate binding pocket [chemical binding]; other site
1185652019045	membrane-bound complex binding site; other site
1185652019046	hinge residues; other site
1185652019047	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652019048	dimer interface [polypeptide binding]; other site
1185652019049	conserved gate region; other site
1185652019050	putative PBP binding loops; other site
1185652019051	ABC-ATPase subunit interface; other site
1185652019052	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1185652019053	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652019054	dimer interface [polypeptide binding]; other site
1185652019055	conserved gate region; other site
1185652019056	putative PBP binding loops; other site
1185652019057	ABC-ATPase subunit interface; other site
1185652019058	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1185652019059	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1185652019060	Walker A/P-loop; other site
1185652019061	ATP binding site [chemical binding]; other site
1185652019062	Q-loop/lid; other site
1185652019063	ABC transporter signature motif; other site
1185652019064	Walker B; other site
1185652019065	D-loop; other site
1185652019066	H-loop/switch region; other site
1185652019067	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652019068	DNA binding residues [nucleotide binding]
1185652019069	dimerization interface [polypeptide binding]; other site
1185652019070	Helix-turn-helix domain; Region: HTH_18; pfam12833
1185652019071	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
1185652019072	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1185652019073	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1185652019074	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
1185652019075	Winged helix-turn helix; Region: HTH_29; pfam13551
1185652019076	Homeodomain-like domain; Region: HTH_32; pfam13565
1185652019077	Winged helix-turn helix; Region: HTH_33; pfam13592
1185652019078	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1185652019079	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652019080	S-adenosylmethionine binding site [chemical binding]; other site
1185652019081	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
1185652019082	Integrase core domain; Region: rve; pfam00665
1185652019083	transposase; Validated; Region: PRK08181
1185652019084	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652019085	Walker A motif; other site
1185652019086	ATP binding site [chemical binding]; other site
1185652019087	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1185652019088	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1185652019089	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1185652019090	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
1185652019091	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
1185652019092	Helix-turn-helix domain; Region: HTH_28; pfam13518
1185652019093	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1185652019094	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
1185652019095	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1185652019096	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1185652019097	active site
1185652019098	DNA binding site [nucleotide binding]
1185652019099	Int/Topo IB signature motif; other site
1185652019100	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1185652019101	active site
1185652019102	DNA binding site [nucleotide binding]
1185652019103	Int/Topo IB signature motif; other site
1185652019104	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1185652019105	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1185652019106	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1185652019107	homotetramer interface [polypeptide binding]; other site
1185652019108	FMN binding site [chemical binding]; other site
1185652019109	homodimer contacts [polypeptide binding]; other site
1185652019110	putative active site [active]
1185652019111	putative substrate binding site [chemical binding]; other site
1185652019112	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
1185652019113	substrate binding pocket [chemical binding]; other site
1185652019114	substrate-Mg2+ binding site; other site
1185652019115	aspartate-rich region 1; other site
1185652019116	aspartate-rich region 2; other site
1185652019117	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
1185652019118	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1185652019119	Cytochrome P450; Region: p450; cl12078
1185652019120	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1185652019121	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1185652019122	substrate binding pocket [chemical binding]; other site
1185652019123	chain length determination region; other site
1185652019124	substrate-Mg2+ binding site; other site
1185652019125	catalytic residues [active]
1185652019126	aspartate-rich region 1; other site
1185652019127	active site lid residues [active]
1185652019128	aspartate-rich region 2; other site
1185652019129	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1185652019130	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1185652019131	Cytochrome P450; Region: p450; cl12078
1185652019132	Permease; Region: Permease; cl00510
1185652019133	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1185652019134	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1185652019135	FeS/SAM binding site; other site
1185652019136	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
1185652019137	agmatinase; Region: agmatinase; TIGR01230
1185652019138	Agmatinase-like family; Region: Agmatinase-like; cd09990
1185652019139	active site
1185652019140	oligomer interface [polypeptide binding]; other site
1185652019141	Mn binding site [ion binding]; other site
1185652019142	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1185652019143	integron integrase; Region: integrase_gron; TIGR02249
1185652019144	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
1185652019145	Int/Topo IB signature motif; other site
1185652019146	Protein of unknown function (DUF1353); Region: DUF1353; pfam07087
1185652019147	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1185652019148	Transposase; Region: HTH_Tnp_1; pfam01527
1185652019149	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652019150	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1185652019151	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1185652019152	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652019153	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1185652019154	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652019155	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1185652019156	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
1185652019157	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1185652019158	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1185652019159	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1185652019160	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
1185652019161	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
1185652019162	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1185652019163	AAA domain; Region: AAA_23; pfam13476
1185652019164	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652019165	Walker A/P-loop; other site
1185652019166	ATP binding site [chemical binding]; other site
1185652019167	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
1185652019168	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1185652019169	dimerization interface [polypeptide binding]; other site
1185652019170	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
1185652019171	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1185652019172	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652019173	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1185652019174	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652019175	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1185652019176	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652019177	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1185652019178	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1185652019179	Transposase; Region: HTH_Tnp_1; pfam01527
1185652019180	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1185652019181	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1185652019182	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1185652019183	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1185652019184	Transposase domain (DUF772); Region: DUF772; pfam05598
1185652019185	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1185652019186	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1185652019187	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1185652019188	MULE transposase domain; Region: MULE; pfam10551
1185652019189	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1185652019190	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1185652019191	active site
1185652019192	Transposase domain (DUF772); Region: DUF772; pfam05598
1185652019193	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1185652019194	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1185652019195	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
1185652019196	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1185652019197	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
1185652019198	DNA binding residues [nucleotide binding]
1185652019199	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
1185652019200	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1185652019201	HSP70 interaction site [polypeptide binding]; other site
1185652019202	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1185652019203	substrate binding site [polypeptide binding]; other site
1185652019204	dimer interface [polypeptide binding]; other site
1185652019205	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
1185652019206	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1185652019207	acetyl-CoA synthetase; Provisional; Region: PRK04319
1185652019208	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
1185652019209	active site
1185652019210	acyl-activating enzyme (AAE) consensus motif; other site
1185652019211	putative CoA binding site [chemical binding]; other site
1185652019212	AMP binding site [chemical binding]; other site
1185652019213	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
1185652019214	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1185652019215	tetramer interface [polypeptide binding]; other site
1185652019216	TPP-binding site [chemical binding]; other site
1185652019217	heterodimer interface [polypeptide binding]; other site
1185652019218	phosphorylation loop region [posttranslational modification]
1185652019219	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1185652019220	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1185652019221	alpha subunit interface [polypeptide binding]; other site
1185652019222	TPP binding site [chemical binding]; other site
1185652019223	heterodimer interface [polypeptide binding]; other site
1185652019224	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1185652019225	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1185652019226	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1185652019227	E3 interaction surface; other site
1185652019228	lipoyl attachment site [posttranslational modification]; other site
1185652019229	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1185652019230	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
1185652019231	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
1185652019232	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
1185652019233	FtsH Extracellular; Region: FtsH_ext; pfam06480
1185652019234	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1185652019235	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1185652019236	Walker A motif; other site
1185652019237	ATP binding site [chemical binding]; other site
1185652019238	Walker B motif; other site
1185652019239	arginine finger; other site
1185652019240	Peptidase family M41; Region: Peptidase_M41; pfam01434
1185652019241	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1185652019242	Ligand Binding Site [chemical binding]; other site
1185652019243	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1185652019244	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1185652019245	putative dimer interface [polypeptide binding]; other site
1185652019246	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1185652019247	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1185652019248	active site
1185652019249	CoA binding site [chemical binding]; other site
1185652019250	AMP binding site [chemical binding]; other site
1185652019251	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1185652019252	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1185652019253	putative acyl-acceptor binding pocket; other site
1185652019254	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
1185652019255	hypothetical protein; Provisional; Region: PRK08609
1185652019256	active site
1185652019257	primer binding site [nucleotide binding]; other site
1185652019258	NTP  binding site [chemical binding]; other site
1185652019259	metal binding triad [ion binding]; metal-binding site
1185652019260	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
1185652019261	active site
1185652019262	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1185652019263	active site
1185652019264	Protein required for attachment to host cells; Region: Host_attach; pfam10116
1185652019265	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1185652019266	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1185652019267	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652019268	Walker A/P-loop; other site
1185652019269	ATP binding site [chemical binding]; other site
1185652019270	Q-loop/lid; other site
1185652019271	ABC transporter signature motif; other site
1185652019272	Walker B; other site
1185652019273	D-loop; other site
1185652019274	H-loop/switch region; other site
1185652019275	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
1185652019276	BON domain; Region: BON; pfam04972
1185652019277	BON domain; Region: BON; pfam04972
1185652019278	BON domain; Region: BON; pfam04972
1185652019279	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
1185652019280	BON domain; Region: BON; pfam04972
1185652019281	BON domain; Region: BON; pfam04972
1185652019282	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
1185652019283	Predicted kinase [General function prediction only]; Region: COG0645
1185652019284	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1185652019285	active site
1185652019286	Glucokinase; Region: Glucokinase; cl17310
1185652019287	Protein required for attachment to host cells; Region: Host_attach; pfam10116
1185652019288	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
1185652019289	Peptidase family M50; Region: Peptidase_M50; pfam02163
1185652019290	active site
1185652019291	putative substrate binding region [chemical binding]; other site
1185652019292	FOG: CBS domain [General function prediction only]; Region: COG0517
1185652019293	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639
1185652019294	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1185652019295	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1185652019296	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1185652019297	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1185652019298	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652019299	intermolecular recognition site; other site
1185652019300	active site
1185652019301	dimerization interface [polypeptide binding]; other site
1185652019302	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652019303	DNA binding site [nucleotide binding]
1185652019304	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652019305	BON domain; Region: BON; pfam04972
1185652019306	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
1185652019307	BON domain; Region: BON; pfam04972
1185652019308	BON domain; Region: BON; pfam04972
1185652019309	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
1185652019310	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1185652019311	30S subunit binding site; other site
1185652019312	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1185652019313	DNA-binding site [nucleotide binding]; DNA binding site
1185652019314	RNA-binding motif; other site
1185652019315	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1185652019316	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1185652019317	ligand binding site [chemical binding]; other site
1185652019318	flexible hinge region; other site
1185652019319	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1185652019320	putative switch regulator; other site
1185652019321	non-specific DNA interactions [nucleotide binding]; other site
1185652019322	DNA binding site [nucleotide binding]
1185652019323	sequence specific DNA binding site [nucleotide binding]; other site
1185652019324	putative cAMP binding site [chemical binding]; other site
1185652019325	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1185652019326	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1185652019327	ligand binding site [chemical binding]; other site
1185652019328	flexible hinge region; other site
1185652019329	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1185652019330	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652019331	motif II; other site
1185652019332	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1185652019333	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1185652019334	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1185652019335	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1185652019336	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1185652019337	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1185652019338	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1185652019339	Glycerate kinase family; Region: Gly_kinase; cl00841
1185652019340	ChaB; Region: ChaB; pfam06150
1185652019341	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
1185652019342	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
1185652019343	active site
1185652019344	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
1185652019345	Putative glucoamylase; Region: Glycoamylase; pfam10091
1185652019346	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
1185652019347	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
1185652019348	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
1185652019349	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1185652019350	Ligand Binding Site [chemical binding]; other site
1185652019351	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1185652019352	Ligand Binding Site [chemical binding]; other site
1185652019353	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1185652019354	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1185652019355	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1185652019356	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1185652019357	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1185652019358	catalytic residue [active]
1185652019359	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
1185652019360	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652019361	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1185652019362	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1185652019363	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652019364	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1185652019365	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1185652019366	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652019367	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1185652019368	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1185652019369	dimer interface [polypeptide binding]; other site
1185652019370	conserved gate region; other site
1185652019371	putative PBP binding loops; other site
1185652019372	ABC-ATPase subunit interface; other site
1185652019373	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1185652019374	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1185652019375	Walker A/P-loop; other site
1185652019376	ATP binding site [chemical binding]; other site
1185652019377	Q-loop/lid; other site
1185652019378	ABC transporter signature motif; other site
1185652019379	Walker B; other site
1185652019380	D-loop; other site
1185652019381	H-loop/switch region; other site
1185652019382	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1185652019383	NMT1-like family; Region: NMT1_2; pfam13379
1185652019384	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1185652019385	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1185652019386	putative substrate binding site [chemical binding]; other site
1185652019387	putative ATP binding site [chemical binding]; other site
1185652019388	FOG: CBS domain [General function prediction only]; Region: COG0517
1185652019389	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
1185652019390	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
1185652019391	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1185652019392	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1185652019393	active site
1185652019394	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
1185652019395	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1185652019396	Ligand Binding Site [chemical binding]; other site
1185652019397	chaperonin GroEL; Reviewed; Region: groEL; PRK12851
1185652019398	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1185652019399	ring oligomerisation interface [polypeptide binding]; other site
1185652019400	ATP/Mg binding site [chemical binding]; other site
1185652019401	stacking interactions; other site
1185652019402	hinge regions; other site
1185652019403	Domain of unknown function (DUF1476); Region: DUF1476; cl11571
1185652019404	Glucokinase; Region: Glucokinase; cl17310
1185652019405	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1185652019406	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1185652019407	putative dimer interface [polypeptide binding]; other site
1185652019408	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1185652019409	Ligand Binding Site [chemical binding]; other site
1185652019410	Protein required for attachment to host cells; Region: Host_attach; pfam10116
1185652019411	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1185652019412	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1185652019413	Walker A/P-loop; other site
1185652019414	ATP binding site [chemical binding]; other site
1185652019415	Q-loop/lid; other site
1185652019416	ABC transporter signature motif; other site
1185652019417	Walker B; other site
1185652019418	D-loop; other site
1185652019419	H-loop/switch region; other site
1185652019420	FtsX-like permease family; Region: FtsX; pfam02687
1185652019421	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1185652019422	FtsX-like permease family; Region: FtsX; pfam02687
1185652019423	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1185652019424	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652019425	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1185652019426	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1185652019427	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1185652019428	protein binding site [polypeptide binding]; other site
1185652019429	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1185652019430	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
1185652019431	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1185652019432	Beta-Casp domain; Region: Beta-Casp; smart01027
1185652019433	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1185652019434	ornithine carbamoyltransferase; Validated; Region: PRK02102
1185652019435	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1185652019436	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1185652019437	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1185652019438	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652019439	active site
1185652019440	phosphorylation site [posttranslational modification]
1185652019441	intermolecular recognition site; other site
1185652019442	dimerization interface [polypeptide binding]; other site
1185652019443	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652019444	DNA binding site [nucleotide binding]
1185652019445	transcriptional regulator FixK; Provisional; Region: fixK; PRK09391
1185652019446	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1185652019447	ligand binding site [chemical binding]; other site
1185652019448	flexible hinge region; other site
1185652019449	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1185652019450	putative switch regulator; other site
1185652019451	non-specific DNA interactions [nucleotide binding]; other site
1185652019452	DNA binding site [nucleotide binding]
1185652019453	sequence specific DNA binding site [nucleotide binding]; other site
1185652019454	putative cAMP binding site [chemical binding]; other site
1185652019455	PAS fold; Region: PAS_4; pfam08448
1185652019456	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652019457	putative active site [active]
1185652019458	heme pocket [chemical binding]; other site
1185652019459	PAS domain S-box; Region: sensory_box; TIGR00229
1185652019460	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1185652019461	putative active site [active]
1185652019462	heme pocket [chemical binding]; other site
1185652019463	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1185652019464	dimer interface [polypeptide binding]; other site
1185652019465	phosphorylation site [posttranslational modification]
1185652019466	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1185652019467	ATP binding site [chemical binding]; other site
1185652019468	G-X-G motif; other site
1185652019469	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652019470	phosphorylation site [posttranslational modification]
1185652019471	intermolecular recognition site; other site
1185652019472	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1185652019473	magnesium-transporting ATPase; Provisional; Region: PRK15122
1185652019474	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1185652019475	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1185652019476	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1185652019477	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1185652019478	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
1185652019479	CoA binding domain; Region: CoA_binding_2; pfam13380
1185652019480	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
1185652019481	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
1185652019482	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1185652019483	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1185652019484	Ligand Binding Site [chemical binding]; other site
1185652019485	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1185652019486	Ligand Binding Site [chemical binding]; other site
1185652019487	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
1185652019488	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
1185652019489	BON domain; Region: BON; pfam04972
1185652019490	BON domain; Region: BON; pfam04972
1185652019491	BON domain; Region: BON; pfam04972
1185652019492	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1185652019493	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1185652019494	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1185652019495	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1185652019496	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1185652019497	motif II; other site
1185652019498	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1185652019499	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
1185652019500	Predicted kinase [General function prediction only]; Region: COG0645
1185652019501	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1185652019502	active site
1185652019503	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1185652019504	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1185652019505	active site
1185652019506	Predicted membrane protein [Function unknown]; Region: COG3174
1185652019507	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
1185652019508	Predicted membrane protein [Function unknown]; Region: COG3619
1185652019509	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1185652019510	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1185652019511	Hemerythrin-like domain; Region: Hr-like; cd12108
1185652019512	Fe binding site [ion binding]; other site
1185652019513	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1185652019514	TAP-like protein; Region: Abhydrolase_4; pfam08386
1185652019515	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1185652019516	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1185652019517	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1185652019518	Cytochrome c; Region: Cytochrom_C; pfam00034
1185652019519	Predicted transporter component [General function prediction only]; Region: COG2391
1185652019520	Sulphur transport; Region: Sulf_transp; pfam04143
1185652019521	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1185652019522	HlyD family secretion protein; Region: HlyD_3; pfam13437
1185652019523	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1185652019524	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1185652019525	FtsX-like permease family; Region: FtsX; pfam02687
1185652019526	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1185652019527	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1185652019528	FtsX-like permease family; Region: FtsX; pfam02687
1185652019529	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652019530	ABC transporter signature motif; other site
1185652019531	Walker B; other site
1185652019532	D-loop; other site
1185652019533	H-loop/switch region; other site
1185652019534	LTXXQ motif family protein; Region: LTXXQ; pfam07813
1185652019535	putative phosphoketolase; Provisional; Region: PRK05261
1185652019536	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
1185652019537	TPP-binding site; other site
1185652019538	XFP C-terminal domain; Region: XFP_C; pfam09363
1185652019539	FOG: CBS domain [General function prediction only]; Region: COG0517
1185652019540	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
1185652019541	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1185652019542	BON domain; Region: BON; pfam04972
1185652019543	ABC1 family; Region: ABC1; cl17513
1185652019544	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1185652019545	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
1185652019546	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1185652019547	Walker A motif; other site
1185652019548	hexamer interface [polypeptide binding]; other site
1185652019549	ATP binding site [chemical binding]; other site
1185652019550	Walker B motif; other site
1185652019551	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
1185652019552	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
1185652019553	VirB7 interaction site; other site
1185652019554	Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736
1185652019555	Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704
1185652019556	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
1185652019557	Type IV secretion system proteins; Region: T4SS; pfam07996
1185652019558	Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451
1185652019559	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
1185652019560	Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702
1185652019561	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
1185652019562	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1185652019563	MarR family; Region: MarR_2; cl17246
1185652019564	Autoinducer synthetase; Region: Autoind_synth; cl17404
1185652019565	Autoinducer synthetase; Region: Autoind_synth; cl17404
1185652019566	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
1185652019567	MerR family regulatory protein; Region: MerR; pfam00376
1185652019568	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1185652019569	P-loop; other site
1185652019570	Magnesium ion binding site [ion binding]; other site
1185652019571	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
1185652019572	ParB-like nuclease domain; Region: ParB; smart00470
1185652019573	Homeodomain-like domain; Region: HTH_23; pfam13384
1185652019574	Winged helix-turn helix; Region: HTH_29; pfam13551
1185652019575	Homeodomain-like domain; Region: HTH_32; pfam13565
1185652019576	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1185652019577	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
1185652019578	LabA_like proteins; Region: LabA_like/DUF88; cl10034
1185652019579	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1185652019580	putative metal binding site [ion binding]; other site
1185652019581	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
1185652019582	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1185652019583	Int/Topo IB signature motif; other site
1185652019584	DNA binding site [nucleotide binding]
1185652019585	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
1185652019586	HTH DNA binding domain; Region: HTH_13; pfam11972
1185652019587	Competence protein CoiA-like family; Region: CoiA; cl11541
1185652019588	Superfamily II helicase [General function prediction only]; Region: COG1204
1185652019589	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1185652019590	ATP binding site [chemical binding]; other site
1185652019591	putative Mg++ binding site [ion binding]; other site
1185652019592	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
1185652019593	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
1185652019594	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1185652019595	AAA domain; Region: AAA_11; pfam13086
1185652019596	Part of AAA domain; Region: AAA_19; pfam13245
1185652019597	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1185652019598	AAA domain; Region: AAA_12; pfam13087
1185652019599	MarR family; Region: MarR_2; pfam12802
1185652019600	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133
1185652019601	PLD-like domain; Region: PLDc_2; pfam13091
1185652019602	putative active site [active]
1185652019603	putative catalytic site [active]
1185652019604	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133
1185652019605	PLD-like domain; Region: PLDc_2; pfam13091
1185652019606	putative active site [active]
1185652019607	putative catalytic site [active]
1185652019608	Part of AAA domain; Region: AAA_19; pfam13245
1185652019609	Family description; Region: UvrD_C_2; pfam13538
1185652019610	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
1185652019611	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1185652019612	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
1185652019613	catalytic site [active]
1185652019614	DNA polymerase III subunit epsilon; Validated; Region: PRK09182
1185652019615	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1185652019616	active site
1185652019617	substrate binding site [chemical binding]; other site
1185652019618	catalytic site [active]
1185652019619	Protein of unknown function (DUF429); Region: DUF429; cl12046
1185652019620	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1185652019621	ATP binding site [chemical binding]; other site
1185652019622	putative Mg++ binding site [ion binding]; other site
1185652019623	nucleotide binding region [chemical binding]; other site
1185652019624	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1185652019625	ATP-binding site [chemical binding]; other site
1185652019626	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1185652019627	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1185652019628	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1185652019629	active site
1185652019630	DNA polymerase IV; Validated; Region: PRK02406
1185652019631	DNA binding site [nucleotide binding]
1185652019632	Uncharacterized conserved protein [Function unknown]; Region: COG4544
1185652019633	DNA Polymerase Y-family; Region: PolY_like; cd03468
1185652019634	active site
1185652019635	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
1185652019636	DNA binding site [nucleotide binding]
1185652019637	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
1185652019638	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
1185652019639	putative active site [active]
1185652019640	putative PHP Thumb interface [polypeptide binding]; other site
1185652019641	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1185652019642	generic binding surface I; other site
1185652019643	generic binding surface II; other site
1185652019644	Helix-turn-helix domain; Region: HTH_17; cl17695
1185652019645	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1185652019646	ParB-like nuclease domain; Region: ParBc; pfam02195
1185652019647	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1185652019648	Antirestriction protein; Region: Antirestrict; pfam03230
1185652019649	Protein of unknown function (DUF1173); Region: DUF1173; pfam06666
1185652019650	YodA lipocalin-like domain; Region: YodA; pfam09223
1185652019651	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1185652019652	S-adenosylmethionine binding site [chemical binding]; other site
1185652019653	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1185652019654	ATP binding site [chemical binding]; other site
1185652019655	putative Mg++ binding site [ion binding]; other site
1185652019656	Helicase_C-like; Region: Helicase_C_4; pfam13871
1185652019657	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1185652019658	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1185652019659	catalytic residues [active]
1185652019660	catalytic nucleophile [active]
1185652019661	Presynaptic Site I dimer interface [polypeptide binding]; other site
1185652019662	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1185652019663	Synaptic Flat tetramer interface [polypeptide binding]; other site
1185652019664	Synaptic Site I dimer interface [polypeptide binding]; other site
1185652019665	DNA binding site [nucleotide binding]
1185652019666	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1185652019667	DNA-binding interface [nucleotide binding]; DNA binding site
1185652019668	Integrase core domain; Region: rve; pfam00665
1185652019669	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1185652019670	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1185652019671	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1185652019672	catalytic residues [active]
1185652019673	catalytic nucleophile [active]
1185652019674	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1185652019675	DNA-binding site [nucleotide binding]; DNA binding site
1185652019676	RNA-binding motif; other site
1185652019677	replication initiation protein RepC; Provisional; Region: PRK13824
1185652019678	Replication protein C N-terminal domain; Region: RP-C; pfam03428
1185652019679	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
1185652019680	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
1185652019681	ParB-like nuclease domain; Region: ParB; smart00470
1185652019682	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
1185652019683	MerR family regulatory protein; Region: MerR; pfam00376
1185652019684	DNA binding residues [nucleotide binding]
1185652019685	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1185652019686	P-loop; other site
1185652019687	Magnesium ion binding site [ion binding]; other site
1185652019688	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1185652019689	Magnesium ion binding site [ion binding]; other site
1185652019690	putative autoinducer synthesis protein; Provisional; Region: PRK13834
1185652019691	conjugal transfer protein TrbC; Provisional; Region: PRK13871
1185652019692	conjugal transfer protein TrbD; Provisional; Region: PRK13823
1185652019693	conjugal transfer protein TrbE; Provisional; Region: PRK13830
1185652019694	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1185652019695	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1185652019696	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1185652019697	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
1185652019698	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652019699	AAA-like domain; Region: AAA_10; pfam12846
1185652019700	Walker A/P-loop; other site
1185652019701	ATP binding site [chemical binding]; other site
1185652019702	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652019703	Walker B; other site
1185652019704	D-loop; other site
1185652019705	H-loop/switch region; other site
1185652019706	conjugal transfer protein TrbJ; Provisional; Region: PRK13842
1185652019707	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314
1185652019708	Protein of unknown function (DUF2749); Region: DUF2749; pfam10907
1185652019709	conjugal transfer protein TrbL; Provisional; Region: PRK13841
1185652019710	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
1185652019711	conjugal transfer protein TrbF; Provisional; Region: PRK13836
1185652019712	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
1185652019713	VirB7 interaction site; other site
1185652019714	conjugal transfer protein TrbH; Provisional; Region: PRK13835
1185652019715	Conjugal transfer protein TrbH; Region: TrbH; pfam07283
1185652019716	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
1185652019717	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
1185652019718	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1185652019719	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1185652019720	DNA binding residues [nucleotide binding]
1185652019721	dimerization interface [polypeptide binding]; other site
1185652019722	Prokaryotic Transcriptional repressor TraM; Region: Prok-TraM; pfam09228
1185652019723	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1185652019724	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1185652019725	Homeodomain-like domain; Region: HTH_32; pfam13565
1185652019726	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652019727	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1185652019728	Integrase core domain; Region: rve; pfam00665
1185652019729	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1185652019730	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1185652019731	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1185652019732	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1185652019733	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652019734	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
1185652019735	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
1185652019736	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1185652019737	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1185652019738	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1185652019739	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1185652019740	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1185652019741	Transposase; Region: HTH_Tnp_1; pfam01527
1185652019742	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1185652019743	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
1185652019744	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1185652019745	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1185652019746	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
1185652019747	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
1185652019748	ATP-binding ABC transporter family nodulation protein NodI; Region: nodI; TIGR01288
1185652019749	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1185652019750	Walker A/P-loop; other site
1185652019751	ATP binding site [chemical binding]; other site
1185652019752	Q-loop/lid; other site
1185652019753	ABC transporter signature motif; other site
1185652019754	Walker B; other site
1185652019755	D-loop; other site
1185652019756	H-loop/switch region; other site
1185652019757	chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242
1185652019758	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1185652019759	DXD motif; other site
1185652019760	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1185652019761	chitooligosaccharide deacetylase NodB; Region: nodulat_NodB; TIGR04243
1185652019762	Nodulation protein A (NodA); Region: NodA; cl17421
1185652019763	coproporphyrinogen III oxidase; Provisional; Region: PRK13347
1185652019764	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1185652019765	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1185652019766	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1185652019767	two-component response regulator VirG; Provisional; Region: PRK13856
1185652019768	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1185652019769	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1185652019770	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1185652019771	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1185652019772	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
1185652019773	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
1185652019774	Sulfatase; Region: Sulfatase; pfam00884
1185652019775	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
1185652019776	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1185652019777	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1185652019778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1185652019779	active site
1185652019780	phosphorylation site [posttranslational modification]
1185652019781	intermolecular recognition site; other site
1185652019782	dimerization interface [polypeptide binding]; other site
1185652019783	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1185652019784	DNA binding site [nucleotide binding]
1185652019785	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
1185652019786	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
1185652019787	active site
1185652019788	catalytic residues [active]